Podcasts about Atherosclerosis

พี่ปุ๋มเพิ่งได้งานวิจัยที่ถือว่าดีที่สุดฉบับแรกที่ได้อ่านในรอบครึ่งปีนี้ เพิ่งตีพิมพ์เมื่อ 25 มิ.ย.2568 ใน Current Opinion of Lipidology ค่ะมีงานวิจัยสนับสนุนหนักแน่นเพิ่มมากขึ้นตลอดระยะเวลา 264 ปีของความเข้าใจคอเลสเตอรอล และกระบวนการเกิด Atherosclerosis คือ1. LDL คือ independent risk factor ในการเพิ่มความเสี่ยง Atherosclerotic Cardiovascular Disease2. ทั้งจำนวนและปริมาณคอเลสเตอรอลที่อยู่ใน ApoB-Containing lipoproteins คือ major risk factors ของ โรคหลอดเลือดหัวใจแต่สิ่งที่น่าสนใจที่สุดจากงานวิจัยฉบับนี้ที่เสริมข้อ 1 และ 2 คือ3. คุณสมบัติที่แตกต่างของ ApoB containing lipoproteins ในคนแต่ละคนที่ติดตัวมา ส่งผลต่อความสามารถในการก่อโรคหลอดเลือดหัวใจอุดตันไม่เท่ากัน (หัวข้อนี้น่าทึ่งสุดๆค่ะ)4. การจัดเรียงตัวและประเภทของไขมันที่แตกต่างกันภายใน lipoprotein particles และ dynamic ของ ApoB-100 ที่อยู่บนผิวของ lipoprotein particle ส่งผลต่อเสถียรภาพของ lipoproteins ชนิดนั้น ในการทำปฏิกิริยาต่อ receptors, ความสามารถในกระบวนการก่อกำเนิด atherosclerosis ที่แตกต่างกัน5. มีปัจจัยที่ส่งอิทธิพลต่อเสถียรภาพของ Low-density lipoprotein particle และ ApoB-100 ซึ่งเปิด frontier ใหม่ของการพัฒนากลยุทธ์การลดความเสี่ยง ASCVD เฉพาะรายบุคคลความก้าวหน้าทางเทคโนโลยีทำให้นักวิจัยเข้าใจ ApoB-100 และ Low-density lipoprotein แบบ molecular structural insightful มากขึ้นค่ะ งานวิจัยเรื่อง ApoB-containing lipoproteins กับ ความสามารถในการก่อ Atherosclerosis เขาก้าวหน้ากันไปถึงไหนแล้ว กูรู้สุขภาพยังงมอยู่กับ “เรื่องเล่า” กับ เคสรายบุคคล (anecdotal case) ที่ไม่ได้อยู่บน evidence-based medicine เลย#หาคำตอบสุขภาพจากงานวิจัยไม่ใช่จากเรื่องเล่า#FatoutHealthspans่มขึ้น

Optimiza tu LDL Colesterol e interpreta tu analítica o las de tus pacientes hoy, sin fármacos, aplicando estrategias nutricionales y suplementos clave con dosis y ciencia. Accede aquí:https://philhugo.com/producto/ldl-colesterol/  ¡Te espero dentro!Los suplementos be levels mencionados que formulo personalmente: Tu código de descuento: INTERGALACTICOBerberina: https://shop.belevels.com/products/berberine?sca_ref=745165.uf0cpcacla Omega 3: https://belevels.com/products/omega3?sca_ref=745165.uf0cpcaclaTriple Magnesio: https://belevels.com/products/magnesium?variant=47417739379012.uf0cpcacla Dosis y los demás explicados en el curso de Control Absoluto del LDL Colesterol.¿Sigues una dieta cetogénica estricta y tu LDL se ha disparado a niveles que asustarían a cualquier médico? No estás solo. En este episodio, desentrañamos la fisiología del Lean Mass Hyperresponder (LMHR): un perfil metabólico donde el colesterol LDL se eleva no por enfermedad, sino por eficiencia energética. Aprende cómo tu hígado, en ausencia de glucosa, convierte grasa en combustible a través de VLDL y LDL. Descubre por qué un LDL de 300 mg/dL puede ser normal si tu HDL está alto, tus triglicéridos bajos y tu inflamación es cero. Estudio a estudio, desmonto los miedos injustificados y propone estrategias clínicas reales para modular tu LDL si es necesario, desde el aumento de carbohidratos limpios hasta la optimización tiroidea y muscular. Este episodio no es para quien se conforma con los rangos de laboratorio estándar. Es para quien quiere entender su cuerpo desde la lógica metabólica y tomar decisiones con ciencia, no con miedo.ReferenciasApoB es biomarcador y posible diana terapéutica cardiovascular. Behbodikhah, Jennifer et al. “Apolipoprotein B and Cardiovascular Disease: Biomarker and Potential Therapeutic Target.” Metabolites vol. 11,10 690. 8 Oct. 2021LDL sube mucho en "lean mass hyper-responders" con dieta baja en carbohidratos. Norwitz, Nicholas G et al. “Elevated LDL Cholesterol with a Carbohydrate-Restricted Diet: Evidence for a "Lean Mass Hyper-Responder" Phenotype.” Current developments in nutrition vol. 6,1 nzab144. 30 Nov. 2021Marcadores tiroideos y composición corporal predicen cambios en LDL con dieta cetogénica. Cooper, Isabella D et al. “Thyroid markers and body composition predict LDL-cholesterol change in lean healthy women on a ketogenic diet: experimental support for the lipid energy model.” Frontiers in endocrinology vol. 14 1326768. 21 Dec. 2023Omega-3 mejora dislipidemia en relación dosis-respuesta. Wang, Tianjiao et al. “Association Between Omega-3 Fatty Acid Intake and Dyslipidemia: A Continuous Dose-Response Meta-Analysis of Randomized Controlled Trials.” Journal of the American Heart Association vol. 12,11 (2023): e029512.Omega-3 de prescripción tiene efectos lipídicos beneficiosos. Bays, Harold E et al. “Prescription omega-3 fatty acids and their lipid effects: physiologic mechanisms of action and clinical implications.” Expert review of cardiovascular therapy vol. 6,3 (2008): 391-409La berberina reduce lípidos, sola o combinada. Koppen, Laura M et al. “Efficacy of Berberine Alone and in Combination for the Treatment of Hyperlipidemia: A Systematic Review.” Journal of evidence-based complementary & alternative medicine vol. 22,4 (2017): 956-968.Niacina baja lipoproteína(a) según fenotipo de apo(a). Artemeva, N V et al. “Lowering of lipoprotein(a) level under niacin treatment is dependent on apolipoprotein(a) phenotype.” Atherosclerosis. Supplements vol. 18 (2015): 53-8

In the first episode of a three-part series on the key factors that limit healthspan, Dr. Erin Faules speaks with Wild Health CEO Dr. Carl Seger about two common but often under-addressed contributors: atherosclerosis and mental health disorders. This episode includes discussion of: Why atherosclerosis often progresses silently, and why calcium scores may miss early disease  The link between depression, chronic stress, and cardiovascular risk  The clinical relevance of advanced screening tools like coronary CTA, LP(a), and AI-driven risk assessment Treatment advances including GLP-1 receptor agonists and psychedelic-assisted therapy This is Part 1 of a 3-part series exploring the 7 most common blocks to healthspan. Over the next two weeks we will dive into atrophy, inflammation, metabolic dysfunction, neurodegenerative disease and cancer.

In this episode of the Heart podcast, Digital Media Editor, Professor James Rudd, is joined by Dr Salvatore Brugaletta from Barcelona, Spain. They discuss the role of inflammation in atherosclerosis, how to detect it using imaging and biomarkers, and promising drugs in the pipeline to reduce inflammation levels. If you enjoy the show, please leave us a positive review wherever you get your podcasts. It helps us to reach more people - thanks! Link to published paper: https://heart.bmj.com/content/early/2025/03/25/heartjnl-2024-325408

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Sex Differences in the Impact of Exercise Volume on Subclinical Coronary Atherosclerosis: A Meta-Analysis.

In this episode, Dr. Valentin Fuster discusses a study showing that elevated cardiac troponin levels after intense exercise in middle-aged recreational athletes are common but not linked to hidden coronary artery disease. The findings raise important questions about the origin and significance of these elevations, highlighting the need for long-term follow-up.

Heart attacks & strokes are down, but guess what's rising? ⚡ Atrial fibrillation,

This week, Dr. Prather talks about how Aerobic Exercise and External CounterPulsation (ECP) Therapy are treatments that benefit every patient and all types of Cardiovascular Disease.  In this episode, you'll find out:—Why Dr. Prather calls ECP Therapy and Aerobic Exercise "the panacea for Cardiovascular Disease".—The amount of Aerobic Exercise each person needs to prevent or reverse Cardiovascular Disease.  (And why everyone reading this probably does not measure up!)—The story of how ECP Therapy was designed by Harvard decades ago to do Aerobic Exercise for patients who couldn't even walk across the room without losing their breath.  Plus, how long-distance runners are using ECP to help set new records. —How Dr. Prather called the FDA to ask if it would be OK for him to offer ECP Therapy to his patients and was actually encouraged by them to do this therapy in his office.—The "amazing" safety record of ECP Therapy that has NEVER had a single injury reported in decades of use.—The screening Dr. Prather does on patients prior to ECP Therapy for potential contraindications to ensure patient safety.—Why Cardiologists refer for ECP Therapy after everything else has been tried.  And how everyone who has been referred to Dr. Prather for it has lived.—The conditions that benefit from ECP Therapy, including:  Angina, Congestive Heart Failure, Atherosclerosis, Hypertension, Kidney Disease, Restless Leg Syndrome, Diabetes, Cognitive Brain Function, and Erectile Dysfunction. —How Natalie and John came to see Dr. Prather without an appointment after leaving two different hospitals.  And how Dr. Prather was able to provide John relief from pain that very first day.—The details about Dr. Prather's upcoming free educational seminar, "Diabetes Decoded:  A Holistic Look At Type 1 and Type 2 Diabetes" on Wednesday, June 25th at 6:30 p.m.http://www.TheVoiceOfHealthRadio.com

The primary cause of metabolic dysfunction is not carbohydrates themselves but rather the combination of processed "naked" sugars and high linoleic acid seed oils that damage mitochondrial function at a cellular level.KISMETWhile most people focus on limiting carbohydrates to improve metabolic health, the research actually shows that fruit juice and honey can improve insulin sensitivity in some diabetics due to their complex chemical structures that positively influence gut bacteria – completely contradicting conventional wisdom about sugar.EPISODE SUMMARYDr. Paul Saladino shares his evidence-based perspective on the true causes of metabolic dysfunction. Contrary to popular belief, carbohydrates themselves don't cause insulin resistance. Instead, the primary culprits are processed "naked" sugars that disrupt gut bacteria and seed oils high in linoleic acid that damage mitochondrial membranes. These damaged membranes lead to energy production inefficiency at the cellular level, which manifests as various metabolic disorders. Dr. Saladino explains how the standard American diet contains 5-10 times more linoleic acid than our ancestors consumed, primarily from seed oils in processed foods. He argues that returning to single-ingredient foods and specifically reducing linoleic acid intake could rapidly improve metabolic health. The discussion challenges conventional medical wisdom about cholesterol, atherosclerosis, and the treatment of metabolic disorders.NOTABLE QUOTE"I want people to know that I was not taught in medical school the diet was this powerful. And that's probably the most important thing that I can do with my career is just tell people like what you eat and the quality of the foods you eat is everything. It's everything."Contact InfoWebsite: PaulSaladinoMD.coSocial Media: @PaulSaladinoMDOrgan Meat Supplements: HeartAndSoil.coMeat Sticks & Such:  LineageProviSend Dr. Ovadia a Text Message. (If you want a response, include your contact information.) Dr. Ovadia can not respond here. To contact his team please email team@ifixhearts.com While supplies last, you can get a free copy of Dr. Ovadia's best-selling book, Stay Off My Operating Table. All you pay for is shipping. Get it here. If you like what you hear, I wanna make it easier for you to take action on your health.Head over to i fix hearts.com/book to grab a copy of my book, Stay Off My Operating Table, and if you're ready to go deeper or talk to someone from my team, just go to i fix hearts.com/talk. Stay Off My Operating Table on X: Dr. Ovadia: @iFixHearts Jack Heald: @JackHeald5 Learn more: Stay Off My Operating Table on Amazon Take Dr. Ovadia's metabolic health quiz: iFixHearts Dr. Ovadia's website: Ovadia Heart Health Jack Heald's website: CultYourBrand.com Theme Song : Rage AgainstWritten & Performed by Logan Gritton & Colin Gailey(c) 2016 Mercury Retro RecordingsAny use of this intellectual property for text and data mining or computational analysis including as training material for artificial intelligence systems is strictly prohibited without express written consent from Dr. Philip Ovadia.

Effect of Colchicine on Progression of Known Coronary Atherosclerosis in Patients With Stable Coronary Artery Disease Compared to Placebo: The Ekstrom Trial

Dr. Martin answers questions sent in by our listeners. Some of today's topics include: Chronic mucus in the throat ApoB & heart disease risk Treatment for rosacea Atherosclerosis & leg-strengthening exercises Polyps Dark rings around the eyes  

You might not realize just how much your oral health is tied to your heart and overall wellness—but it's a connection worth knowing about. I caught up again with my amazing colleague, Dr. Ellie Campbell, and we got into why regular lab tests sometimes miss the early signs of things like heart disease, stroke, and even dementia. We talked about why your dentist could actually be one of the most important people on your health team, plus some sneaky risks that only advanced testing can catch. Dr. Ellie has been in family medicine for over 25 years, mixing integrative and functional approaches to help people truly understand their health. She shared some eye-opening stuff about how sleep apnea can mess with your blood sugar, why fasting blood sugar numbers matter more than you think, and how your genes could be playing a bigger role than you realize. She also gave some solid advice on how to speak up for yourself in a medical system that doesn't always connect these dots. If you're someone who wants to take better care of yourself and catch problems before they sneak up, this episode is packed with tips that really hit home. And by the way, just to sweeten things up—my new Mighty Maca Mango is out now, perfect for spring and summer. It's a delicious twist on Mighty Maca that you can toss in sparkling water or make into popsicles. Check it out anytime at dranna.com—it's a little treat with big benefits.   Key Timestamps: [00:00:00] Introduction. [00:04:54] How to know if you have cardiovascular disease. [00:10:09] Corrupted LDL cholesterol explained. [00:11:32] Oxidative stress and antioxidants. [00:15:54] Gender differences in blood sugar. [00:20:20] Increased mortality with very low blood sugar. [00:24:21] Continuous glucose monitors' impact. [00:28:56] LDL cholesterol management post-heart attack. [00:32:03] Markers of oxidative stress. [00:36:43] ApoE4 gene and health risks. [00:39:57] 2 recommended radiology tests for patients over 40. [00:46:13] Atherosclerosis awareness and prevention.   Memorable Quotes: "People with the highest cholesterol live the longest. You heard that right." [00:10:30] – Dr. Ellie Campbell "I believe that we saved that patient from a heart attack or a stroke by identifying leading indicators in blood that told me she had a dental problem that took three dentists to find." [00:34:21] – Dr. Ellie Campbell   Links Mentioned: Mighty Maca Mango: https://drannacabeca.com/products/mighty-maca The Blood Pressure Blueprint: https://bpblueprint.com/   Connect with Dr. Ellie Campbell: Website: https://www.campbellfamilymedicine.com/ Instagram: https://www.instagram.com/ellie.cfm/   Connect with Dr. Anna Cabeca: Website: https://drannacabeca.com/pages/show Instagram: https://www.instagram.com/thegirlfrienddoctor/ YouTube: https://www.youtube.com/@thegirlfrienddoctor TikTok: https://www.tiktok.com/@drannacabeca   Produced by Evolved Podcasting: www.evolvedpodcasting.com

You might not realize just how much your oral health is tied to your heart and overall wellness—but it's a connection worth knowing about. I caught up again with my amazing colleague, Dr. Ellie Campbell, and we got into why regular lab tests sometimes miss the early signs of things like heart disease, stroke, and even dementia. We talked about why your dentist could actually be one of the most important people on your health team, plus some sneaky risks that only advanced testing can catch. Dr. Ellie has been in family medicine for over 25 years, mixing integrative and functional approaches to help people truly understand their health. She shared some eye-opening stuff about how sleep apnea can mess with your blood sugar, why fasting blood sugar numbers matter more than you think, and how your genes could be playing a bigger role than you realize. She also gave some solid advice on how to speak up for yourself in a medical system that doesn't always connect these dots. If you're someone who wants to take better care of yourself and catch problems before they sneak up, this episode is packed with tips that really hit home. And by the way, just to sweeten things up—my new Mighty Maca Mango is out now, perfect for spring and summer. It's a delicious twist on Mighty Maca that you can toss in sparkling water or make into popsicles. Check it out anytime at dranna.com—it's a little treat with big benefits.   Key Timestamps: [00:00:00] Introduction. [00:04:54] How to know if you have cardiovascular disease. [00:10:09] Corrupted LDL cholesterol explained. [00:11:32] Oxidative stress and antioxidants. [00:15:54] Gender differences in blood sugar. [00:20:20] Increased mortality with very low blood sugar. [00:24:21] Continuous glucose monitors' impact. [00:28:56] LDL cholesterol management post-heart attack. [00:32:03] Markers of oxidative stress. [00:36:43] ApoE4 gene and health risks. [00:39:57] 2 recommended radiology tests for patients over 40. [00:46:13] Atherosclerosis awareness and prevention.   Memorable Quotes: "People with the highest cholesterol live the longest. You heard that right." [00:10:30] – Dr. Ellie Campbell "I believe that we saved that patient from a heart attack or a stroke by identifying leading indicators in blood that told me she had a dental problem that took three dentists to find." [00:34:21] – Dr. Ellie Campbell   Links Mentioned: Mighty Maca Mango: https://drannacabeca.com/products/mighty-maca The Blood Pressure Blueprint: https://bpblueprint.com/   Connect with Dr. Ellie Campbell: Website: https://www.campbellfamilymedicine.com/ Instagram: https://www.instagram.com/ellie.cfm/   Connect with Dr. Anna Cabeca: Website: https://drannacabeca.com/pages/show Instagram: https://www.instagram.com/thegirlfrienddoctor/ YouTube: https://www.youtube.com/@thegirlfrienddoctor TikTok: https://www.tiktok.com/@drannacabeca   Produced by Evolved Podcasting: www.evolvedpodcasting.com

Colchicine

The Lancet Commission calls for a shift from focusing on late-stage ischaemia to targeting early atherosclerosis (ACAD)

Hypertension is known as the ‘silent killer,' but what if I told you it's NOT just about cholesterol or genetics? Today, we're diving deep into hypertension, heart disease, and how a functional medicine approach can transform cardiovascular health. My guest, Dr. Abid Husain, MD, FACC, ABAARM, FSSRP, is a board-certified cardiologist who integrates cellular medicine, hormone optimization, and cutting-edge therapies to address the real root causes of cardiovascular disease.In this episode, we break down:✅ The true causes of high blood pressure (hint: it's more than just salt and stress!)✅ The best exercise strategies proven to lower blood pressure✅ How hormones, peptides, and GLP-1 receptor agonists play a major role in cardiovascular health✅ Supplements that help – and some that you might want to avoid✅ Why inflammation and oxidative stress are the real threats to your heart

Let's break down key insights from a recent two-hour and 20-minute conversation between Dr. Peter Attia and renowned lipidologist Tom Dayspring. Support your Intermittent Fasting lifestyle with the Berberine Fasting Accelerator  by MYOXCIENCE: https://bit.ly/berberine-fasting-accelerator Use code podcast to save 12% Get the Blood Work Cheat Sheet: https://courses.highintensityhealth.com/blood-work-cheat-sheet Show Notes: https://bit.ly/4hrDc72 Time Stamps:  0:00 Intro 0:52 Cholesterol's Role in Atherosclerosis  1:51 Triglycerides & Insulin Resistance: The Overlooked Risk Markers  3:28 Lipoprotein Exchange & Insulin Resistance  7:18 Triglycerides to HDL Ratio as a Risk Indicator  8:36 Metabolically Healthy Phenotype & LDL: 9:20 Sauna Therapy for Cardiovascular Health: 11:00 Cholesterol, Endothelial Health & Plaque Formation: 14:53 Case Study: A 24-Year-Old Athlete with High LDL 21:00 Lipoprotein(a) (LP(a)) and Its Role in Cardiovascular Risk:

In this week's podcast, a potential new therapeutic target in beta-thalassemia. The E3 ubiquitin ligase AMBRA1 promotes autophagic clearance of free alpha-globin. Researchers describe mutations in the AMBRA1 gene that impair this clearance, exacerbating ineffective erythropoiesis and disease severity. After that: targeting MYD88 mutations. Lasalocid-A is a compound that selectively binds to the MYD88 L265P mutant protein, which is found in a range of B-cell lymphomas. New research shows its potential to inhibit tumor growth, overcome ibrutinib resistance, and synergize with venetoclax. Finally: air pollution is linked to an increased risk of venous thromboembolism in a prospective, community-based cohort study. The findings highlight the harms of pollution, and support the case for global efforts to improve public health.Featured Articles:Mutations in AMBRA1 aggravate β-thalassemia by impairing autophagy-mediated clearance of free α-globinLasalocid A selectively induces the degradation of MYD88 in lymphomas harboring the MYD88 L265P mutationAir pollution is associated with increased risk of venous thromboembolism: the Multi-Ethnic Study of Atherosclerosis

Join Dr. Martin in today's episode of The Doctor Is In Podcast.  

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on The mC2HEST Score for Incident Atrial Fibrillation: MESA (Multi-Ethnic Study of Atherosclerosis)

Erectile Dysfunction affects 20-30 million American men and is likely under-reported. But 85% of cases are due to underlying health issues like Cardiovascular Disease. In this episode, you'll learn:—The difference between Male Impotence and Erectile Dysfunction.—How pharmaceuticals (like anti-Cholesterol medicines, Beta Blockers, and anti-depressants) are big contributors to E.D.—The astonishing statistics about declining Testosterone levels in military men since World War II. (And how these low levels are even being seen in young men who are still teenagers.)—The role Atherosclerosis and Diabetes play in E.D. And how Atherosclerosis is the #1 contributor to E.D.—Why it is "very rare" for men over 50 to have E.D. due to psychological and not physical causes. And how your libido is a key indicator for your overall health.—The "Hand Test" Dr. Prather says you can use to gauge the health of a man's erection. —Why alcohol has a negative effect on male performance and can actually shrink the testicles. And how smoking even TWO cigarettes can cause E.D.—The dangers of marijuana use for male sexual performance, including issues of infertility. And why Dr. Prather says it is "really difficult" to get Testosterone levels back up to normal levels in marijuana users.—How pornography is actually destroying male sexual performance, not enhancing it. —Why Dr. Prather says your sexual life is linked to your nutrition and "the better your nutrition, the better your virility". And the natural supplements that help with male sexual performance.http://www.TheVoiceOfHealthRadio.com

1. “Bioaccumulation of Microplastics in Decedent Human Brains” (Nature Medicine, 2024)   This study confirms the presence of microplastics and nanoplastics (MNPs) in human brain tissue, particularly the frontal cortex. Researchers used pyrolysis gas chromatography-mass spectrometry (Py-GC/MS) and electron microscopy to analyze postmortem samples, finding polyethylene (PE) as the dominant plastic type. Brain tissue exhibited significantly higher plastic concentrations than the liver or kidney, with even greater MNP accumulation in individuals diagnosed with dementia. The findings raise concerns about potential neuroinflammation and long-term neurological effects, though causality remains unproven.   2. “Microplastics and Nanoplastics in Atheromas and Cardiovascular Events” (New England Journal of Medicine, 2024)   This study investigates the presence of microplastics in atherosclerotic plaques and their potential role in cardiovascular disease. Analyzing carotid artery plaques from patients undergoing endarterectomy, researchers found polyethylene (PE) and polyvinyl chloride (PVC) in 58.4% of plaques. Patients with MNP-containing plaques had a 4.53 times higher risk of heart attack, stroke, or death over a three-year follow-up. The study also linked MNP presence to elevated inflammatory markers (IL-18, IL-1β, TNF-α, IL-6), suggesting that microplastics might exacerbate cardiovascular disease progression.

In this episode, we review the high-yield topic of⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Atherosclerosis ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠from the Cardiovascular section. Follow ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Medbullets⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbullets

Doctors fleeing Medicare—leaving patients stranded; CEO murder heightens scrutiny of United Healthcare's Medicare Advantage coding shenanigans; Can blood pressure spikes cause strokes? Does a calcium score of 20 call for a statin Rx? Treatments for postural orthostatic tachycardia syndrome (POTS); New “improved” tea bags release millions of plastic microparticles; The surprising trigger of a bout of hives. 

High in fats and low in carbs, ketogenic diets were originally developed in the 1920s to treat children with epilepsy. Now, they've gained popularity for weight loss, and even improved cognitive function. But how much truth is there in the purported brain health benefits we see on social media? In this episode of ‘Your Brain On...', we separate the facts from the fads, and discuss: • What one might eat on a typical ketogenic diet • How ketogenic diets affect brain metabolism • The different ways your brain uses sources of energy — glucose vs. ketones • The latest data on ketogenic diet in Alzheimer's disease patients • What we know about how ketogenic diets and treatment of Alzheimer's • The outcome differences between ketogenic diets and ketone supplements in Alzheimer's • Other evidence-based nutritional approaches for brain health  For this episode, we welcome two world-renowned professionals in the field of nutrition and neuroscience: DR. MATTHEW TAYLOR, PhD, RD, Assistant Professor, Dietetics and Nutrition, Kansas University Medical Center DR. RUSSELL SWERDLOW, MD, Gene and Marge Sweeney Professor of Neurology; Director, Alzheimer's Disease Research Center, Kansas University Medical Center This is... Your Brain On Ketogenic Diets. ‘Your Brain On' is hosted by neurologists, scientists and public health advocates Ayesha and Dean Sherzai. ‘Your Brain On... Ketogenic Diets' • SEASON 4 • EPISODE 4   FOLLOW US Instagram: @thebraindocs Website: TheBrainDocs.com More info and episodes: TheBrainDocs.com/Podcast   REFERENCES 1. Wheless, James W. "History of the ketogenic diet." Epilepsia 49 (2008): 3-5. 2. Krolak-Salmon, Pierre, Russell H. Swerdlow, Thibault Mastain, Catherine Dive-Pouletty, Nick Pooley, and Masoumeh Kisomi. "Efficacy and Safety of Exogenous Ketones in People with Mild Neurocognitive Disorder and Alzheimer's Disease: A Systematic Literature Review." Nutrition Reviews (2024): nuae098. 3. Taylor, Matthew K., Debra K. Sullivan, Jonathan D. Mahnken, Jeffrey M. Burns, and Russell H. Swerdlow. "Feasibility and efficacy data from a ketogenic diet intervention in Alzheimer's disease." Alzheimer's & Dementia: Translational Research & Clinical Interventions 4 (2018): 28-36. 4. Taylor, Matthew K., Russell H. Swerdlow, and Debra K. Sullivan. "Dietary neuroketotherapeutics for Alzheimer's disease: an evidence update and the potential role for diet quality." Nutrients 11, no. 8 (2019): 1910. 5. Koppel, Scott J., and Russell H. Swerdlow. "Neuroketotherapeutics: a modern review of a century-old therapy." Neurochemistry international 117 (2018): 114-125. 6. O'Neill, Blair, and Paolo Raggi. "The ketogenic diet: Pros and cons." Atherosclerosis 292 (2020): 119-126. 7. Crosby, Lee, Brenda Davis, Shivam Joshi, Meghan Jardine, Jennifer Paul, Maggie Neola, and Neal D. Barnard. "Ketogenic diets and chronic disease: weighing the benefits against the risks." Frontiers in nutrition 8 (2021): 702802.

CONFIRM-2: Artificial Intelligence Enabled Quantitative CT Assessment of Atherosclerosis and Major Adverse Events: A Multi-Center International Registry

In this episode of Longevity Roadmap, Buck Joffrey presents a case study of a 70-year-old patient with optimal metabolic health but elevated LDL and APOB levels, emphasizing the importance of aggressive lipid management in preventing coronary artery disease. Buck also explores the genetic factors related to Alzheimer's risk and the implications of lipid levels on cognitive health, advocating for proactive treatment strategies. 00:00 - Introduction to Longevity Roadmap 03:08 - Case Study: A 70-Year-Old Patient's Health 12:07 - Understanding Lipid Management and Atherosclerosis 19:49 - Genetic Factors in Alzheimer's Risk and Lipid Management

Dr. Peter Attia's opinion of the Carnivore Diet, LDL, APOb, and Atherosclerosis risk, while speaking with Derek Cole of More Plates More Dates, with Mike Dolce's response and commentary. You have to hear this! 

In this episode of The Nutritional Therapy and Wellness Podcast, host Jamie Belz and guest Amanda Jones dive into the fascinating science of blood sugar regulation and how its imbalance impacts the body. They explore how prediabetes and type II diabetes—like many chronic diseases—can often be reversed through strategic diet and lifestyle changes. Discover how achieving balanced blood sugar not only improves energy and vitality but also reduces or eliminates many associated health risks altogether. Amanda Jones is a dedicated instructor with the Nutritional Therapy Association (NTA) and an experienced Functional Nutritional Therapy Practitioner since 2013. In addition to being an FNTP, Amanda holds a master's degree in Human Nutrition and Functional Medicine, a bachelors degree in communications, she's a certified ADAPT Functional Health Coach, a certified GAPS Practitioner and a licensed massage therapist. 2:55 Diabetes, pre-diabetes, insulin - Blood Sugar 101 4:00 Why blood sugar regulation matters 4:45 Blood sugar regulation impacts everything in the entire body - nothing is NOT impacted 5:20 Current statistics for the prevalence of diabetes and pre-diabetes 6:50 Subclinical blood dysregulation - insulin resistance (PRE-PRE-DIABETES) 7:50 Reversing the pathway toward diabetes 10:45 How blood sugar dysregulation impacts the cardiovascular system - cardio-metabolic disease 11:50 Atherosclerosis as a result of blood sugar dysregulation 13:54 Glucose conversion to body fat 14:22 Blood lipids - triglycerides - hyperlipidemia 14:37 Why SUGAR is contributing to obesity rather than fats - as well as circulating lipids - 15:33 How elevated blood sugar drives elevated blood pressure and high blood pressure 16:20 How high insulin levels inhibit the production of nitric oxide levels 18:00 Immune regulation and meta-inflammation - inflammation driven by metabolic problems 19:30 Endocrine disruption from blood sugar dysregulation 21:10 Changes to the nervous system, gut motility, our microbiome, and other things negatively impacted by blood sugar dysregulation 21:40 The stages of dysglycemia 22:37 Insulin is a GOOD hormone! - What it's supposed to do in the body - how it brings sugar into the cells - how energy is produced 24:33 Excess glucose and insulin - reactive hypoglycemia 25:00 The Blood Sugar Rollercoaster - why you're tired at 10:30 AM, 2:30 PM, 8:00 PM 27:02 Insulin resistance 28:12 Fasting Glucose Levels - lab testing - Fasting Insulin Levels 30:20 The progression continues - feeling lethargic, gaining weight, etc. 30:30 Pre-Diabetes diagnosis 31:00 A1C - glycation 31:41 Metabolic Syndrome 32:40 Pancreas damage - insulin injections 33:04 Six small meals per day versus fasting 37:30 Fasting and time-restricted eating 38:09 Our blood sugar is synced with our circadian rhythms 39:58 Walking after meals versus other workouts for blood sugar regulation 41:46 There is HOPE! This doesn't need to be a miserable process. YOU can do it and you can enjoy it! ______________________ Catch Episode 29 to learn quick tips for improving blood sugar regulation for optimal health. Hit Subscribe! Connect with us at www.nutritionaltherapy.com

Statistically speaking, cardiovascular disease is the most likely thing both to kill you and to make you stop living before you die.  Knowing the most likely thing to cause the the thing that is most likely to kill you can help you decide what to deliberately put on autopilot in your daily life to drastically decrease your chances of becoming a statistic so you're more able to help the people who need you most as you get older rather than the other way around.Free list of supplement brands I trustsend me a message: healthcouragecollective@gmail.comMy Website

Optimal Medical Therapy in Peripheral Artery Disease   Guest: Stan Henkin, M.D. Host: Malcolm R. Bell, M.D.   Atherosclerosis of peripheral (ie, non-coronary) arteries, also known as peripheral artery disease (PAD), affects more than 8 million Americans. Unfortunately, compared to coronary artery disease (CAD), PAD is often underdiagnosed and undertreated. In this podcast, experts discuss optimal medical therapy in patients with PAD.   Topics Discussed: What is peripheral artery disease? What are the most common symptoms of PAD? You diagnose PAD. What pharmacologic and non-pharmacologic therapies do you consider? How do you follow-up a patient with PAD? When should a patient be referred to a vascular specialist?   Connect with Mayo Clinic's Cardiovascular Continuing Medical Education online at https://cveducation.mayo.edu or on Twitter @MayoClinicCV and @MayoCVservices. LinkedIn: Mayo Clinic Cardiovascular Services Cardiovascular Education App: The Mayo Clinic Cardiovascular CME App is an innovative educational platform that features cardiology-focused continuing medical education wherever and whenever you need it. Use this app to access other free content and browse upcoming courses. Download it for free in Apple or Google stores today! No CME credit offered for this episode. Podcast episode transcript found here.

When discussing cardiovascular health, few topics stir as much debate as cholesterol, particularly in relation to low-carb and ketogenic diets. Recently, there's been significant attention given to a proposed model that suggests high LDL cholesterol may not pose the same cardiovascular risk in certain individuals, specifically those labeled as “lean mass hyper-responders.” This raises important questions: Is it possible that high cholesterol might not be dangerous for everyone? Or are we witnessing a dangerous misinterpretation of the science? In this episode, we break down the ideas behind the “lipid energy model” and explore how it has been framed in the context of low-carbohydrate and ketogenic diets. While proponents claim this model sheds light on how some people can have elevated LDL without increasing heart disease risk, critics warn that miscommunication and oversimplification of these ideas are leading many down a dangerous path. With real-world health decisions hanging in the balance, it's crucial to carefully examine what the science truly says about cholesterol, inflammation, and heart disease. Join us as we dive into the evidence with Dr. Gary McGowan. We'll dissect what the current research supports, what remains speculative, and how social media has amplified both the promising and problematic aspects of this model. If you've ever wondered about the impact of high cholesterol on heart disease risk in the context of ketogenic or low-carb diets, this episode is essential listening. Timestamps 02:27 What are the “Lean Mass Hyper Responder” phenotype and the “Lipid Energy Model” 27:29 Looking at recent publications and the “KETO Trial” 47:06 Public communication and misinterpretation 51:18 Clinical implications of diet-induced dyslipidemia 55:14 Responsibility in scientific communication 57:30 Real-world examples of poor communication or misinterpretation 01:13:27 Ethical concerns with the promotion of the model 01:25:59 Final thoughts Related Resources Go to episode page Join the Sigma email newsletter for free Subscribe to Sigma Nutrition Premium Enroll in the next cohort of our Applied Nutrition Literacy course Find Dr. McGowan at: Triage Method Instagram: @drgarymcgowan Papers discussed in this episode: Norwitz et al., 2022 – The Lipid Energy Model: Reimagining Lipoprotein Function in the Context of Carbohydrate-Restricted Diets Norwitz et al., 2021 – Elevated LDL Cholesterol with a Carbohydrate-Restricted Diet: Evidence for a “Lean Mass Hyper-Responder” Phenotype KETO Trial: Budoff et al., 2024 – Carbohydrate Restriction-Induced Elevations in LDL-Cholesterol and Atherosclerosis

Dupilimab received FDA approval as the first biologic treatment for adults with uncontrolled COPD, reducing exacerbations significantly in clinical trials. A study in JAMA Internal Medicine demonstrated that improper arm positioning during blood pressure measurements can lead to overestimated readings, potentially causing misdiagnosis. Another study in Atherosclerosis, Thrombosis, and Vascular Biology linked COVID-19 to long-term risks of major adverse cardiac events (MACE), with increased risks for patients hospitalized with COVID-19 and those with non-O blood types. These findings underscore the need for attention to proper clinical practices and long-term monitoring of cardiovascular health post-COVID-19.

In this episode, Dr. Valentin Fuster discusses a groundbreaking study linking urinary metal levels, particularly non-essential metals like cadmium and uranium, to coronary artery calcification, highlighting their potential role in cardiovascular disease. The findings underscore the urgent need for public health initiatives to address environmental metal exposure, as they could significantly mitigate cardiovascular risks and health disparities.

Broadcast from KSQD, Santa Cruz on 9--12-2024: Dr. Dawn explains gout, its causes, and conventional and alternative medical approaches to treating it. The role of the gut microbiome in gout is explored, including how certain bacteria can influence uric acid levels. Diet and lifestyle recommendations for managing gout are discussed, including prebiotic-rich foods and fermented foods. The Glycocalyx, a thin membrane lining blood vessels, is introduced as an important factor in cardiovascular health. Factors that damage and protect the Glycocalyx are discussed, including the effects of hyperglycemia and certain medications. Rhamnan sulfate, derived from seaweed, is highlighted as a potential supplement for improving vascular health and reducing atherosclerotic plaques. A new method of testing for sleep apnea using sweat analysis is presented, offering a potential alternative to current diagnostic methods. The show compares surgical and non-surgical approaches to treating Achilles tendon ruptures, discussing the benefits of functional bracing over immobilization.

Broadcast from KSQD, Santa Cruz on 9--12-2024: Dr. Dawn explains gout, its causes, and conventional and alternative medical approaches to treating it. The role of the gut microbiome in gout is explored, including how certain bacteria can influence uric acid levels. Diet and lifestyle recommendations for managing gout are discussed, including prebiotic-rich foods and fermented foods. The Glycocalyx, a thin membrane lining blood vessels, is introduced as an important factor in cardiovascular health. Factors that damage and protect the Glycocalyx are discussed, including the effects of hyperglycemia and certain medications. Rhamnan sulfate, derived from seaweed, is highlighted as a potential supplement for improving vascular health and reducing atherosclerotic plaques. A new method of testing for sleep apnea using sweat analysis is presented, offering a potential alternative to current diagnostic methods. The show compares surgical and non-surgical approaches to treating Achilles tendon ruptures, discussing the benefits of functional bracing over immobilization.

For the past 60 years the medical community has obsessively focused on lowering LDL-cholesterol levels… Research shows these five preventable health conditions make LDL-Cholesterol more likely to cause artery plaque build-up, even if your LDL-Cholesterol levels are low. Sponsored: Crush your Workouts and stay hydrated this summer with the Electrolyte + Creatine Combo by MYOXCIENCE: https://bit.ly/electrolyte-stix *Save with code podcast at checkout Link to Video and Show Notes: https://bit.ly/3WfpI5R Research Mentioned: Zanoni, P., Velagapudi, S., Yalcinkaya, M., Rohrer, L. & Eckardstein, A. von. Endocytosis of lipoproteins. Atherosclerosis 275, 273–295 (2018). Ference, B. A., Braunwald, E. & Catapano, A. L. The LDL cumulative exposure hypothesis: evidence and practical applications. Nat. Rev. Cardiol. 1–16 (2024) doi:10.1038/s41569-024-01039-5. Time Stamps: 00:45 LDL's link with atherosclerosis is nuanced.  02:30 Initial damage to the arterial wall makes LDL levels problematic. 03:45 Increases risk of arterial wall damage: elevated blood pressure, insulin resistance/diabetes, smoking/vaping, obesity, elevated blood viscosity, consuming oxidizableoils. 08:40 High LDL and high triglycerides suggest insulin resistance and increased cardiovascular risk. 09:50 Start with diet and exercise together. 11:20 Statins have concerning side effects. 13:15 Plaque formation begins early in life. 13:50 High LDL is found in centenarians. 14:44 Centenarians are metabolically healthy. 15:40 Your liver makes LDL cholesterol. 16:10 Every cell in your body requires cholesterol. 18:00  Diets high in seed oils make your LDL more likely to be oxidized. 20:55 30-50% of people who have heart attacks have optimal serum cholesterol.

Episode #315. What is ApoB and why should you care? In this latest instalment of our masterclass series, I've distilled the essential insights about apolipoprotein B (ApoB) into one informative episode. Join top experts including Dr Thomas Dayspring, Dr William Cromwell, Danny Lennon, Dr Alan Flanagan, and Dr Gil Carvalho as they unravel the significance of ApoB as a crucial marker of cardiovascular health. This episode provides a thorough understanding of why ApoB matters and how it impacts your health. We unpack the essentials of ApoB, covering its role in cholesterol transport and why it's a key marker for heart disease risk. You'll learn how ApoB affects cardiovascular health, from the way it modifies LDL particles to its impact on atherosclerosis and longevity. We discuss the best ways to measure ApoB, its normal levels, and what causes it to rise. The episode also explores the relationship between ApoB and saturated fats, and why it's a more reliable risk marker than LDL cholesterol. By the end, you'll have a clear understanding of why ApoB matters for your heart health and how it can help guide better health choices. Specifically, we discuss: Introduction (00:00) Lipoproteins & Cholesterol: Transport and Recycling (00:43) Cholesterol's Role in Lipoproteins (26:40) Is ApoB a More Accurate Marker of Cardiovascular Risk? (31:13) Endothelial Transcytosis of Lipoproteins (39:42) LDL Modification and Aggregation (49:17) Evidence for ApoB's Role in Atherosclerosis (55:49) ApoB and Genetics (58:29) ApoB and Longevity (1:02:16) Mechanisms Behind Elevated ApoB Levels (1:05:14) Why ApoB is the Best Predictor of Cardiovascular Disease (1:08:52) ApoB vs LDL-Cholesterol: Understanding the Discordance (1:21:00) Healthy ApoB Levels for Young Adults (1:31:39) Causes of Elevated ApoB Levels (1:45:16) Target ApoB Levels for Cardiovascular Disease Prevention (2:04:31) The History and Evolution of the Lipid Hypothesis (2:07:27) Role of ApoB Lipoproteins in Atherosclerosis (2:10:21) Importance of ApoB as a Cardiovascular Risk Marker and Its Clinical Application (2:18:39) Impact of Saturated Fat on ApoB and Cardiovascular Disease (2:27:47) Top Saturated Fat Foods That Increase Cardiovascular Risk (2:33:53) Impact of Saturated Fat on ApoB and Cardiovascular Disease (2:35:49) Dietary Changes to Lower ApoB Levels (2:38:59) Outro (2:45:54) Read more about the guests featured on this episode or connect with them on their respective pages on The Proof website: Dr Thomas Dayspring, Dr William Cromwell, Danny Lennon, Dr Alan Flanagan, and Dr Gil Carvalho. This episode is brought to you by: InsideTracker If you want to improve your health, you need to measure where you're currently at. InsideTracker analyses up to 48 blood biomarkers including ApoB, LDL, HDL, A1C, and more before giving you advice to optimise your health. Get a 20% discount on your first order at insidetracker.com/simon. BON CHARGE Enhance skin health, increase collagen production, and reverse sun damage with BON CHARGE, my choice of low-level light therapy. Holistic, evidence-based, premium products for healthier skin. Get started at boncharge.com and use code THEPROOF for a 15% discount. Shopify Shopify, the world's leading e-commerce platform, helps you turn browsers into buyers with the internet's best-converting check out–up to 36% better compared to other leading e-commerce platforms. To boost your conversion rate, and grow your business, sign up for a one-dollar-per-month trial period at shopify.com/proof. Sun Home Saunas Invest in your body and mind with Sun Home Saunas, pioneers in crafting premium saunas and cold plunges. Safe, effective, research-backed wellness tools to improve cardiovascular health, offer psychological benefits, and reduce muscle soreness. Head to sunhomesaunas.com/theproof for $300 off your purchase. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Author of The Proof is in the Plants