Podcasts about Atherosclerosis

Welcome to the latest Midlife Minute. This episode unpacks ongoing research on Lp(a), explores how women's lipids change during the perimenopause-to-menopause transition, and clarifies what we can do about it. Stay tuned for more! IN THIS EPISODE, YOU WILL LEARN: How total cholesterol, LDL, and ApoB tend to rise most steeply around the final menstrual period, rather than increasing gradually with chronological aging Why women should have their Lp(a) checked both before and after menopause How oral and transdermal estradiol can affect LDL, HDL, triglycerides, and Lp(a) differently Why I recommend including ApoB when checking your lipids during the perimenopause window How your lifestyle can reduce your cardiovascular risk, even when your Lp(a) is elevated Why omega-3 fatty acids and commonly used lipid medications do not lower Lp(a) Why supplements are not replacements for statins in genuinely high-risk patients  I review the various PCSK9 inhibitors currently available, how they are administered, and their effects  How a CAC, a CT angiogram, and an AI-assisted CT angiogram can help women and their providers determine how aggressive their approach should be when Lp(a) is elevated Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website. Submit your questions to support@cynthiathurlow.com  Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow.  Purchase Cynthia's book, The Menopause Gut. Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line References: 1. Menopause Transition and Cardiovascular Disease Risk: Implications for Timing of Early Prevention: A Scientific Statement From the American Heart Association.Circulation. 2020. El Khoudary SR, Aggarwal B, Beckie TM, et al.Guideline 2. Menopause: A Cardiometabolic Transition. The Lancet. Diabetes & Endocrinology. 2022. Nappi RE, Chedraui P, Lambrinoudaki I, Simoncini T.Review 3. Dyslipidemia Across the Menopause Transition: Mechanisms, Trajectories, and Opportunities for Cardiovascular Prevention. Maturitas. 2026. Castaneda R, Tatit CP, Hurtado Andrade MD, Faubion SS, Shufelt CL.RecentReview 4. Lipoprotein(a) and Women's Cardiovascular Health: A Review. JACC. Advances. 2026. Michos ED, Saucier S, Mehran R, Koschinsky ML. 5. Lipid Metabolism in Women: A Review. Atherosclerosis. 2025. van Oortmerssen JAE, Mulder JWCM, Kavousi M, Roeters van Lennep JE.Review 6. Are Changes in Cardiovascular Disease Risk Factors in Midlife Women Due to Chronological Aging or to the Menopausal Transition?. Journal of the American College of Cardiology. 2009. Matthews KA, Crawford SL, Chae CU, et al.Observational 7. Trajectories of Lipids Around the Menopause Transition in Chinese Women: Results of the Kailuan Cohort Study. Fertility and Sterility. 2023. Dai Q, Wu S, Cao Z, et al. 8. Lipid Management in Patients With Endocrine Disorders: An Endocrine Society Clinical Practice Guideline. The Journal of Clinical Endocrinology and Metabolism. 2020. Newman CB, Blaha MJ, Boord JB, et al.Guideline 9. The Effects of Menopause Hormone Therapy on Lipid Profile in Postmenopausal Women: A Systematic Review and Meta-Analysis. Frontiers in Pharmacology. 2022. Nie G, Yang X, Wang Y, et al.SR 10. Perspectives on Dyslipidemia and Coronary Heart Disease in Women. Journal of the American College of Cardiology. 2005. Bittner V.Review 11. Dyslipidemia in Midlife Women: Approach and Considerations During the Menopausal Transition. Maturitas. 2022. Torosyan N, Visrodia P, Torbati T, Minissian MB, Shufelt CL.Review 12. Effects of gender, age and menopausal status on serum apolipoprotein concentrations.13.Lipoprotein(a).The Journal of the American Medical Association. 2025. Mora S, Kronenberg     14. Why, how and in whom should we measure levels of lipoprotein(a): A review of the latest evidence and clinical implications. Diabetes, Obesity & Metabolism. 2025. Razavi AC, Bhatia HS, Blumenthal RS, Shapiro MD, Mehta A.RecentReview 15. Red Yeast Rice for Hypercholesterolemia: JACC Focus Seminar. Journal of the American College of Cardiology. 2021. Cicero AFG, Fogacci F, Zambon A.Review 16. Overall and Sex-Specific Effect of Berberine for the Treatment of Dyslipidemia in Adults: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials. Drugs. 2023. Blais JE, Huang X, Zhao JV.SR 17. Non-Genetic Influences on Lipoprotein(a) Concentrations. Atherosclerosis. 2022. Enkhmaa B, Berglund L.Review 18. NHLBI Working Group Recommendations to Reduce Lipoprotein(a)-Mediated Risk of Cardiovascular Disease and Aortic Stenosis. Journal of the American College of Cardiology. 2018. Tsimikas S, Fazio S, Ferdinand KC, et al.Review 19. Consumption of a defined, plant‐based diet reduces lipoprotein(a), inflammation, and other atherogenic lipoproteins and particles within 4 weeks. Clinical Cardiology. 2018. Najjar RS, Moore CE, Montgomery BD. 20. Lipoprotein(a): Current Evidence for a Physiologic Role and the Effects of Nutraceutical Strategies. Clinical Therapeutics. 2019. Santos HO, Kones R, Rumana U, et al.Review 21. Effect of Lipid-Lowering Therapies on Lipoprotein(a) Levels: A Comprehensive Meta-Analysis of Randomized Controlled Trials. Atherosclerosis. 2025. Xie S, Galimberti F, Olmastroni E, et al.Recent 22. Effect of Omega-3 Fatty Acid Supplementation on the Postprandial Metabolism of Apolipoprotein(a) in Familial Hypercholesterolemia. Journal of Atherosclerosis and Thrombosis. 2023. Ying Q, Croyal M, Chan DC, et al.RCT 23.Lipoprotein(a) and Cardiovascular Disease. Lancet. 2024. Nordestgaard BG, Langsted A.Review 24. Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A Scientific Statement From the American Heart Association. Arteriosclerosis, Thrombosis, and Vascular Biology. 2022. Reyes-Soffer G, Ginsberg HN, Berglund L, et al.Guideline 25.Clinical Trial Design for Lipoprotein(a)-Lowering Therapies: JACC Focus Seminar 2/3.Journal of the American College of Cardiology. 2023. Malick WA, Goonewardena SN, Koenig W, Rosenson RS.Review 26.2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Dyslipidemia: A Report of the American Collegeof Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2026. Writing Committee Members, Blumenthal RS, Morris PB, et al.Guideline 27. Noninvasive Coronary Atherosclerotic Plaque Imaging. JACC. Cardiovascular Imaging. 2023. Kwiecinski J, Tzolos E, Williams MC, et al.Review 28. Computed Tomography Angiography Versus Agatston Score for Diagnosis of Coronary Artery Disease in Patients With Stable Chest Pain: Individual Patient Data Meta-Analysis of the International COME-CCT Consortium. European Radiology. 2022. Wieske V, Walther M, Dubourg B, et al.SR 29. Association of Coronary Artery Calcium Score With Qualitatively and Quantitatively Assessed Adverse Plaque on Coronary CT Angiography in the SCOT-HEART Trial. European Heart Journal. Cardiovascular Imaging. 2022. Osborne-Grinter M, Kwiecinski J, Doris M, et al.Clinical Trial 30. AI-Guided Quantitative Plaque Staging Predicts Long-Term Cardiovascular Outcomes in Patients at Risk for Atherosclerotic CVD. JACC. Cardiovascular Imaging. 2024. Nurmohamed NS, Bom MJ, Jukema RA, et al.Observational 31. The Lancet Commission on Rethinking Coronary Artery Disease: Moving From Ischemia to Atheroma. Lancet. 2025. Zaman S, Wasfy JH, Kapil V, et al.Review 32. Efficacy and safety of novel lipoprotein(a)‐targeted therapies: A systematic review and meta‐analysis of randomized controlled trials. Diabetes, Obesity & Metabolism. 2026. Santana AUL, Yusufzai MO, Freitas APS, et al. Recent Opinion

Welcome to the latest Midlife Minute. Today, I'm answering listeners' questions about cardiovascular risk, focusing on Lp(a), LDL, statins, and the changes women experience after menopause. Stay tuned for more! IN THIS EPISODE, YOU WILL LEARN: Why women should have their Lp(a) checked both before and after menopause How Lp(a) works as a risk enhancer, and how cardiovascular risk becomes more significant when elevated Lp(a) occurs alongside high LDL Why family history is particularly helpful for women with a 10-year calculated cardiovascular risk that looks reassuringly low I review the current guidelines for primary prevention Why, even though research has shown reductions in major cardiac events with GLP-1s, GLP-1s do not replace statins for lowering LDL  What a CAC score can reveal about coronary artery calcification, and what it cannot detect How AI-assisted CT angiography (such as Clearly) can map, quantify, and characterize plaque throughout the coronary branches Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website. Submit your questions to support@cynthiathurlow.com  Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow.  Purchase Cynthia's book, The Menopause Gut. Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line References: 1.  ​Lipoprotein(a) and Women's Cardiovascular Health: A Review. JACC. Advances. 2026. Michos ED, Saucier S, Mehran R, Koschinsky ML.Recent 2.  ​Sex Differences of Lipoprotein(a) Levels and Associated Risk of Morbidity and Mortality by Age: The Copenhagen General Population Study. Atherosclerosis. 2022. Simony SB, Mortensen MB, Langsted A, et al. 3. Managing Atherosclerotic Cardiovascular Risk in Young Adults: JACC State-of-the-Art Review. Journal of the American College of Cardiology. 2022. Stone NJ, Smith SC, Orringer CE, et al.Review 4. Thirty-Year Risk of Cardiovascular Disease Among Healthy Women According to Clinical Thresholds of Lipoprotein(a). JAMA Cardiology. 2026. Nordestgaard AT, Chasman DI, Moorthy V, et al.RecentObservational 5.  ​Lipoprotein(a).The Journal of the American Medical Association. 2025. Mora S, Kronenberg  6. Clinical Practice Guideline on Lipid Management for Cardiovascular Disease Risk Reduction. Department of Veterans Affairs (2026). 2026. Paul Heidenreich, Lance Spacek, Neil Gregor, et al. Guideline 7. Lipoprotein(a) and Family History Predict Cardiovascular Disease Risk. Journal of the American College of Cardiology. 2020. Mehta A, Virani SS, Ayers CR, et al.Observational 8. 2010 ACCF/AHA Guideline for Assessment of Cardiovascular Risk in Asymptomatic Adults: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Journal of the American College of Cardiology. 2010. Greenland P, Alpert JS, Beller GA, et al.Guideline 9. Prevalence and Prognostic Implications of Coronary Artery Calcification in Low-Risk Women. The Journal of the American Medical Association. 2016. Kavousi M, Desai CS, Ayers C, et al.SR 10. ​Coronary Artery Calcium Scores and Risk for Cardiovascular Events in Women Classified as “Low Risk” Based on Framingham Risk Score: The Multi-Ethnic Study of Atherosclerosis (MESA). Archives of Internal Medicine. 2007. Lakoski SG, Greenland P, Wong ND, et al.Observational 11. 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Journal of the American College of Cardiology. 2019. Arnett DK, Blumenthal RS, Albert MA, et al.Guideline 12. HOPE for Rational Statin Allocation for Primary Prevention: A Coronary Artery Calcium Picture Is Worth 1000 Words. Mayo Clinic Proceedings. 2020. Orringer CE, Maki KC.Review 13. Summary of Updated Recommendations for Primary Prevention of Cardiovascular Disease in Women: JACC State-of-the-Art Review. Journal of the American College of Cardiology. 2020. Cho L, Davis M, Elgendy I, et al.Review 14. Health Maintenance in Postmenopausal Women. American Family Physician. 2025. Plesa M, Wong A, Katsaggelos E.Guideline 15.  ​Semaglutide and Cardiovascular Outcomes by Baseline HbA1c and Change in HbA1c in People With Overweight or Obesity but Without Diabetes in SELECT. Diabetes Care. 2024. Lingvay I, Deanfield J, Kahn SE, et al.RCT 16.  ​Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes. The New England Journal of Medicine. 2023. Lincoff AM, Brown-Frandsen K, Colhoun HM, et al.RCT 17. Long-Term Weight Loss Effects of Semaglutide in Obesity Without Diabetes in the SELECT Trial. Nature Medicine. 2024. Ryan DH, Lingvay I, Deanfield J, et al.RCT 18. Interventions for the Prevention and Management of Cardiometabolic Multiple Long-Term Conditions. Lancet. 2026. Valabhji J, Hope D, Sayed NE, et al.RecentReview 19. Glucagon‐Like Peptide‐1 Receptor Agonists and Major Adverse Cardiovascular Events in Patients With and Without Diabetes: A Meta‐Analysis of Randomized‐Controlled Trials. Clinical Cardiology. 2024. Hosseinpour A, Sood A, Kamalpour J, et al.SR 20. ​FDA Orange Book. FDA Orange Book. 2026. 21. 10. Cardiovascular Disease and Risk Management: Standards of Care in Diabetes-2026. Diabetes Care. 2026. American Diabetes Association Professional Practice Committee for Diabetes*.RecentGuideline 22. Premature Coronary Artery Disease in Women: Sex-Specific Risk Factors, Pathogenetic Mechanisms and Clinical Implications. Annals of Medicine. 2026. Li F, Hong D, Yang M, et al.RecentReview 23. Cardiovascular Disease Risk Factors in Women: The Impact of Race and Ethnicity: A Scientific Statement From the American Heart Association. Circulation. 2023. Mehta LS, Velarde GP, Lewey J, et al.Guideline 24. Preventing CVD in Women: Common Questions and Answers. American Family Physician. 2023. Westfall E, Viere AB, Genewick JE.Review 25. Menopause Transition and Cardiovascular Disease Risk: Implications for Timing of Early Prevention: A Scientific Statement From the American Heart Association. Circulation. 2020. El Khoudary SR, Aggarwal B, Beckie TM, et al.Guideline

For decades, "high cholesterol" has been treated as a diagnosis in itself - but Dr. Barrett breaks down why that's outdated thinking. Using advanced lab markers now available through services like Function Health, he walks through five common cholesterol myths: that high cholesterol equals heart disease, that LDL-C tells the whole story, that high HDL is automatically protective, that diet alone drives your LDL levels, and that a normal total cholesterol means low risk. He explains where ApoB, LPA, and insulin resistance fit into a modern cardiovascular risk model - and the three tests he recommends everyone over 30 get checked.. . . Watch the episode on YouTube here! Click here to view the episode transcript! Podcast Team Dr. Barrett Deubert - Host Grant Crenshaw - Editor (00:00) - Intro (01:14) - High Cholesterol = Heart Disease? (03:17) - LDL-C vs ApoB? (07:08) - High HDL Protects You? (09:12) - Diet Alone Determines LDL? (12:53) - Normal Cholesterol = Low Risk? (15:22) - Omega-3s & Cardiovascular Risk (17:17) - 5 Truth Statements (18:30) - Closing Thoughts DISCLAIMERThis content is strictly the opinion of Dr. Barrett Deubert and is for informational and educational purposes only. It is not intended to provide medical advice or to replace medical advice or treatment from a physician. All viewers of this content are advised to consult their doctors or qualified health professionals regarding health questions and concerns. Neither Dr. Deubert nor the Real Health Co. takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. All audience members, especially those taking prescription or over-the-counter medications, should consult their physicians before beginning any nutrition, supplement, or lifestyle program.

This week, Dr. Kahn reviews several important studies presented at the European Society of Cardiology Congress. The REACT trial examined how often previously undetected atherosclerosis appears in the coronary, carotid, and femoral arteries. The results are startling and reinforce the importance of the #TestNotGuess approach to cardiovascular health. Dr. Kahn also discusses encouraging research showing how plant-based diets may reduce cardiovascular disease risk.  Additional topics include: NT-proBNP testing for predicting future cardiovascular disease The connection between coronary calcium scores and dementia risk Hormone replacement therapy and dementia Dietary flavanols and Parkinson's disease Blood pressure medications that may help protect the brain Blood thinners for people with lower-risk atrial fibrillation Vitamin K2 and the progression of coronary calcification This episode is sponsored by delicious and healthy WellBean. Use discount code DrKahn15 at checkout.

Atherosclerosis. Multiple sclerosis. Amyotrophic lateral sclerosis.Three very different diagnoses—but they all contain the same word.Why?On this episode of Sugar Crush: The Rest of the Story, Dr. Rick Jacoby starts with the Greek origins of sclerosis, meaning “hardening,” and follows that thread through more than 150 years of medical history to ask a provocative question: Could diseases we treat as completely separate conditions share pieces of the same underlying biological process? Drawing on his decades of work with diabetic neuropathy and peripheral nerve surgery, Dr. Rick lays out his Global Compression Theory. He discusses inflammation, fibrosis, glycation, the polyol pathway, nitric oxide, oxygen deprivation, and the physical compression of nerves—and explains why he believes sugar plays a central role in that process.

ReferencesHorm Mol Biol Clin Investig.2023 Feb 17;44(3):295-303.Curr Opin Lipidol. 2017 Oct;28(5):397–402.J Atheroscler Thromb 2024 Sep 1;31(9):1263-1276.Atherosclerosis, 2005; 185, 191-200Org.Letters. 2018.Volume 20, Issue 2,Pages 333-336Guerra, DJ.2026. Unpublished LecturesMiller, S et al 1970.SMBVhttps://music.youtube.com/playlist?list=OLAK5uy_mMurbyyiMLz7bvTAJmI_j8sCs_e-NbvAM&si=KOOTFVnG4G1ZbWYm

CardioNerds (Drs. Dr. Natalie Marrero, Dr. Ritika Tuli, and Dr. Rafael Toro Manotas) discuss multimodality imaging for risk stratification, evaluation, and management of chronic coronary artery disease with Dr. Panithaya Chareonthaitawee. Audio editing by CardioNerds intern Iman Razeghian. This episode was produced as part of the CardioNerds Academy curriculum by House Taussig under the guidance of House Chief, Dr. Natalie Marrero and Academy Program Director, Dr. Gurleen Kaur. A matching review article will be published in US Cardiology Review, the official journal of CardioNerds. This discussion was planned in collaboration with the Mayo Clinic Cardiovascular Board Review Course. In this episode, we discuss the pathophysiology and risk stratification of chronic coronary artery disease (CAD), as well as the current landscape of non-invasive evaluation of this condition. CAD remains a leading cause of morbidity and mortality despite advances in pharmacological and non-pharmacological strategies for the prevention and treatment of atherosclerotic disease. The concept of chronic CAD has shifted from the traditional model of stable, obstructive, flow-limiting disease, toward the current understanding of a dynamic process that extends beyond obstructive epicardial lesions to include non-obstructive plaque, diffuse atherosclerosis, and microvascular disease. Similarly, the imaging modalities used to evaluate CAD have evolved, and clinicians now have an extensive menu of options, each with distinct advantages and limitations, that must be selected carefully to maximize diagnostic accuracy and optimize treatment guidance, while also considering resource availability, local expertise, and high-value care. By the end of the episode, listeners will understand the pathophysiology of chronic CAD, risk-stratify patients with suspected CAD, recognize the advantages and pitfalls of each non-invasive diagnostic modality, and select the most appropriate diagnostic tool for a given clinical scenario. Enjoy this Circulation 2022 Paths to Discovery article to learn about the CardioNerds story, mission, and values. CardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Pearls: Chronic CAD is a complex process that extends beyond obstructive epicardial stenosis to include non-obstructive disease, dynamic plaque burden and ischemia, diffuse atherosclerosis, microvascular dysfunction, vasospasm, among others. When evaluating patients with suspected CAD, the diagnostic process should be guided by a specific and appropriate clinical question before ordering any tests. The current diagnostic tool arsenal is broadly divided into anatomic and functional imaging modalities. These are complementary, each with distinct properties and limitations, addressing different clinical questions and assessing different aspects of disease. Local availability and expertise, along with patient-specific considerations and contraindications, determine the choice of diagnostic modality. No single test is best for every patient. INOCA and coronary microvascular dysfunction represent a common and increasingly recognized entity that is diagnosable and treatable; initial evaluation includes non-invasive testing such as stress PET and stress CMR. References Gulati M, Levy PD, Mukherjee D, et al. 2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR Guideline for the Evaluation and Diagnosis of Chest Pain: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2021;144(22):e368-e454. doi:10.1161/CIR.0000000000001029 https://pubmed.ncbi.nlm.nih.gov/34709879/ Vrints C, Andreotti F, Koskinas KC, et al. 2024 ESC Guidelines for the management of chronic coronary syndromes. Eur Heart J. 2024;45(36):3415-3537. doi:10.1093/eurheartj/ehae177 https://pubmed.ncbi.nlm.nih.gov/39210710/ Virani SS, Newby LK, Arnold SV, et al. 2023 AHA/ACC/ACCP/ASPC/NLA/PCNA Guideline for the Management of Patients With Chronic Coronary Disease: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines. Circulation. 2023;148(9):e9-e119. doi:10.1161/CIR.0000000000001168 https://pubmed.ncbi.nlm.nih.gov/37471501/ Edvardsen T, Asch FM, Davidson B, et al. Non-Invasive Imaging in Coronary Syndromes: Recommendations of The European Association of Cardiovascular Imaging and the American Society of Echocardiography, in Collaboration with The American Society of Nuclear Cardiology, Society of Cardiovascular Computed Tomography, and Society for Cardiovascular Magnetic Resonance. J Am Soc Echocardiogr. 2022;35(4):329-354. doi:10.1016/j.echo.2021.12.012 https://pubmed.ncbi.nlm.nih.gov/35379446/ Douglas PS, Hoffmann U, Patel MR, et al. Outcomes of anatomical versus functional testing for coronary artery disease. N Engl J Med. 2015;372(14):1291-1300. doi:10.1056/NEJMoa1415516 https://pubmed.ncbi.nlm.nih.gov/39210710/ Sharma A, Coles A, Sekaran NK, et al. Stress Testing Versus CT Angiography in Patients With Diabetes and Suspected Coronary Artery Disease. J Am Coll Cardiol. 2019;73(8):893-902. doi:10.1016/j.jacc.2018.11.056 https://pubmed.ncbi.nlm.nih.gov/30819356/ SCOT-HEART Investigators, Newby DE, Adamson PD, et al. Coronary CT Angiography and 5-Year Risk of Myocardial Infarction. N Engl J Med. 2018;379(10):924-933. doi:10.1056/NEJMoa1805971 https://pubmed.ncbi.nlm.nih.gov/30145934/ Li Z, Xu T, Wang Z, et al. Prognostic Significance of Computed Tomography-Derived Fractional Flow Reserve for Long-Term Outcomes in Individuals With Coronary Artery Disease. J Am Heart Assoc. 2025;14(2):e037988. doi:10.1161/JAHA.124.037988 https://pubmed.ncbi.nlm.nih.gov/39791423/ Bateman TM, Al-Mallah MH, et al. Clinical indications for positron emission tomography myocardial perfusion imaging and myocardial blood flow quantification: An American Society of Nuclear Cardiology position statement. J Nucl Cardiol. 2026;57:102619. doi:10.1016/j.nuclcard.2025.102619 https://pubmed.ncbi.nlm.nih.gov/41482140/ Taqueti VR, Di Carli MF. Coronary Microvascular Disease Pathogenic Mechanisms and Therapeutic Options: JACC State-of-the-Art Review. J Am Coll Cardiol. 2018;72(21):2625-2641. doi:10.1016/j.jacc.2018.09.042 https://pubmed.ncbi.nlm.nih.gov/30466521/ Taqueti VR, Hachamovitch R, Murthy VL, et al. Global coronary flow reserve is associated with adverse cardiovascular events independently of luminal angiographic severity and modifies the effect of early revascularization. Circulation. 2015;131(1):19-27. doi:10.1161/CIRCULATIONAHA.114.011939 https://pubmed.ncbi.nlm.nih.gov/25400060/ Mehta PK, Huang J, Levit RD, Malas W, Waheed N, Bairey Merz CN. Ischemia and no obstructive coronary arteries (INOCA): A narrative review. Atherosclerosis. 2022;363:8-21. doi:10.1016/j.atherosclerosis.2022.11.009 https://pubmed.ncbi.nlm.nih.gov/36423427/ Kunadian V, Chieffo A, Camici PG, et al. An EAPCI Expert Consensus Document on Ischaemia with Non-Obstructive Coronary Arteries in Collaboration with European Society of Cardiology Working Group on Coronary Pathophysiology & Microcirculation Endorsed by Coronary Vasomotor Disorders International Study Group. EuroIntervention. 2021;16(13):1049-1069. doi:10.4244/EIJY20M07_01 https://pubmed.ncbi.nlm.nih.gov/32624456/

Most mayos, salad dressings and chips “made with 100% avocado oil” fail test; Borderline cholesterol—will a coronary calcium scan help decide whether a statin is warranted? Aged Garlic Extract for blood pressure; Immune benefits of BWH Beta Glucan. 

In this episode, Jurgita Valaikienė speaks with Cristina Duque about the multimodal assessment of carotid plaques at risk and their role in cerebrovascular disease.

Lower HDL doesn't mean worse. Esselstyn explains how inflammation flips HDL's role—and why plants still win. #HDLCholesterol #Inflammation #PlantBasedScience #HealthTalks

Why can two people with similar LDL levels experience radically different cardiovascular outcomes?  In this episode, I speak with Peter Anderson about the possibility that endothelial nitric oxide may be one of the major variables separating these outcomes.We explore whether nitric oxide can be understood as a protective “bank” that is progressively depleted by ageing, hypertension, smoking, insulin resistance, obesity, sleep deprivation, psychological stress and circadian disruption.We also discuss dietary nitrate, rocket and beetroot, oral bacteria, sunlight, ultraviolet A, infrared light, movement, erectile function, flow-mediated dilation, ketosis, statins, calcium scores and the emerging controversy surrounding coronary CT analysis in lean-mass hyper-responders.CONSULT DR MAX

Dealing with the heat - Europeans' disdain for air conditioningI have scaly and bumpy areas on my scalp that itch!Did homeopathic human growth hormone increase my cholesterol?

Dr. Joel Kahn explores the latest science on supplements that may help slow or reverse atherosclerosis, building on a recent discussion from Simon Hill's The Proof podcast. He takes a closer look at the evidence behind vitamin K2, niacin, pycnogenol with centella asiatica, beta-cyclodextrin, and bergamot, explaining where the research is strongest and what it could mean for heart health. Additional topics include new research on nutrient deficiencies to watch for in vegan diets, the potential kidney risks of certain calcium channel blockers, the health benefits of onions, advanced plaque measurements from coronary CT angiography, the connection between periodontal disease and kidney disease, and how fasting-mimicking diets may improve gum health. Dr. Kahn also reviews encouraging early results from an emerging Lipoprotein(a)-lowering therapy that could reduce the need for lipoprotein apheresis.  Dr. Kahn is leading a group PROLON fasting-mimicking diet beginning this Sunday, July 12, and continuing for five days. A PROLON kit is required and can be purchased at prolonlife.com/drkahn. The NextGen version is recommended.  Finally, a giant thanks to this week's sponsor, Igennus. Learn more at igennus.com/drkahn.

He explains how heme iron, saturated fat, and branched-chain amino acids in meat contribute to heart disease, diabetes, and aging. #HemeIron #AnimalFat #MetabolicHealth #Longevity

Co-Deputy Director of SAHMRI Professor Peter Psaltis joined Kate & Tom to discuss what atherosclerosis is and what work SAHMRI are doing to help with treatment. See omnystudio.com/listener for privacy information.

Nitric Oxide Explained: Vascular Health, Exercise Performance, and N1o1 with Dr. Nathan Bryan, international Leader in Molecular Medicine, the first to describe nitrite and nitrate as indispensable nutrients required for optimal cardiovascular health. He details NO as a ubiquitous messenger affecting blood flow, erectile function, cognition, exercise performance, endothelial dysfunction, and aging-related declines in NO production. Bryan explains why PDE5 inhibitors like Viagra prolong cyclic GMP signaling but don't fix NO deficiency, and why beet products often fail due to variable nitrate content and inadequate dosing. He outlines his NO lozenge approach that generates NO gas from sodium nitrite and magnesium ascorbate, plus a fermented beet powder drink (NOBeets), and emphasizes the role of oral bacteria (and harms of antiseptic mouthwash/fluoride) in nitrate conversion. They review published endpoints, including flow-mediated dilation, blood pressure effects, inflammation markers, triglycerides, stem cells, plaque regression, applications to Alzheimer's, glaucoma/microvascular disease, safety/dosing considerations, risks of arginine supplementation, and a dual-chamber topical NO serum developed from wound-healing experience.

"Making the effort earlier totally changes the trajectory for the rest of your life,” says Jeremy London, MD. London is a board-certified cardiovascular surgeon with more than 25 years of clinical experience caring for patients across the full spectrum of heart disease — from prevention to advanced intervention. Dr. London received his medical degree from the Medical College of Georgia and completed his general surgery residency at Joseph's Hospital in Denver, Colorado. He completed a general vascular and thoracic surgical fellowship at the Carolinas Medical Center in Charlotte, N.C. To deepen his understanding of medicine, he completed the Institute of Functional Medicine core program. 00:00 - When a cardiac surgeon has a heart attack 10:46 - Waking up with different priorities 13:49 - Missed signals 18:35 - The CGM experiment that revealed pre-diabetes 21:43 - The 5 tests that actually matter 25:44 - Diving into Lp(a) 30:36 - Target numbers for primary prevention 32:26 - Why taking medication isn't failure 38:24 - Atherosclerosis starts in childhood 41:19 - Why a zero calcium score doesn't mean you're safe 45:40 - What we don't know 48:41 - GLP-1s & the future of prevention For more about London, visit his website: https://drjeremylondon.com/  We hope you enjoy this episode, and feel free to watch the full video on YouTube! Whether it's an article or podcast, we want to know what we can do to help here at mindbodygreen. Let us know at: podcast@mindbodygreen.com. Learn more about your ad choices. Visit megaphone.fm/adchoices

On Episode 65 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the June 2026 issue of Stroke: "AI-Derived LA Volume Index, LA/RA and LA/LV Volume Ratios From Coronary Artery Calcium Scans Predict Long-Term Atrial Fibrillation and Stroke" and "Prevalence and Association of Atherosclerosis to Ischemic Stroke in Patients With Atrial Fibrillation on Anticoagulation." She also interviews Dr. Randolph Marshall, principal investigator of the Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis–Hemodynamics (CREST-H) study. For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20260603.690307

With Edoardo Conte and Daniele Andreini, Galeazzi-Sant'Ambrogio Hospital IRCCS, Milan - Italy and Gal Tsaban, Mayo Clinic, Rochester - USA. Link to paper Link to editorial

It’s fascinating to see your own heart. Recently, I did. Chest pain led me to see a doctor, who ordered tests that allowed me to see that my heart has calcium buildup. More than I should have. Atherosclerosis, the doctors call it: hardening of the arteries. I’ve made big diet and exercise changes. But I’ve also realized that my cardiac concerns didn’t emerge overnight. In my case, they were the fruit of unhealthy choices. In time, those habits couldn’t help but impact my heart’s health. Scripture uses similar language to describe being spiritually unhealthy. Our hearts can gradually grow hardened toward God—one day and one choice at a time. Hebrews 3:7–8 (referencing Psalm 95:7–8) says, “Today, if you hear his voice, do not harden your hearts as you did in the rebellion.” After God delivered His people from Egypt, they “tested and tried [Him]” (v. 9) during their time in the wilderness. God had faithfully provided for His people, but they refused to see it (vv. 9–10). What about us? What habits nudge us away from God—day by day hardening our hearts against Him? We all make some of those choices. So I’m thankful that today, right now, God offers to exchange our hearts of stone for those softened by His love (see Ezekiel 36:26).

Hydrogen water—breakthrough or scam? Osteoporosis fixes; Nattokinase for cardiovascular prevention; Why vitamin D helps a subset of diabetics; When oral vitamin D doesn't work, sublingual D may normalize blood levels; Vitamin D found beneficial for colitis; Why fructose stokes food cravings; Flawed fluoridation study claims no IQ harms to kids.

Even half an egg a day increases mortality. Replacing red meat with soy, nuts, or plants slashes risk of death and disease. #CholesterolTruth #EggRisk #HealthyProtein

Drs. Sanossian and Saver highlight emerging evidence that routine dental care and oral hygiene may function as actionable, modifiable contributors to stroke prevention beyond traditional vascular risk factors. They also review CREST-2 data showing that carotid revascularization in asymptomatic high-grade carotid stenosis reduces stroke risk, but does not appear to confer additional cognitive benefit over intensive medical therapy alone.

Is oatmeal healthy?I have a higher-than-normal carotid artery intima-media thickness and no appreciable plaque. Should I be concerned?Should my husband and I take the hepatitis B vaccine?

This month on Episode 83 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the March 27th and April 10th issue of Circulation Research. This Episode also features a discussion with Dr Martin Schwartz and Dr Hanqiang Deng about their study, FOXO1 Integrates Endothelial Hemodynamic, Inflammatory, and Metabolic Pathways in Atherosclerosis.   Article highlights: Tadokoro, et al. CRISPR Base Editing of PKCα Rescues Heart Failure Joki, et al. PTH Affects Right Heart Hemodynamics Compendium on Migration of Mitochondria Beyond Cell Boundary

Plant-based diets reverse heart disease better than statins or surgeries, while meat and dairy elevate cholesterol and cancer risk. #HeartHealth #Cholesterol #PlantBasedReversal #CardiovascularCare

Would strontium help in the healing of lumbar fractures?  How about as a preventive?How valuable is the hs-CRP test?  Are there any drawbacks to eating canned fish?What are your thoughts on Arterosil for cardiovascular health?

The benefits of saunaThe Take Back Your Health TourA follow-up on milk thistle interactions with drugsWhat are your thoughts on low-dose saw palmetto for hair growth?Is monk fruit a safe sweetener to use?

What are your thoughts on peptides?So it's not possible to get enough protein from plants only?What about the downsides to animal protein?Are there any negative reports on the usage of extra virgin olive oil?Is it true that the nutritional value of farmed seafood is the same as wild caught?

Highlights from Dr. Hoffman's New Zealand bike tripDo you prefer whey protein isolate or concentrate?My liver enzymes went up taking a statin drug. My doctor recommends I take milk thistle. What are your thoughts?If any supplement protocols are out of stock, should we make substitutions?

Commentary by Dr.  Jian'an Wang

Discover all of the podcasts in our network, search for specific episodes, get the Optimal Living Daily workbook, and learn more at: OLDPodcast.com. Episode 3308: Dr. Neal Malik explains why atherosclerosis can persist even with statins, diet, and lifestyle changes, highlighting the role of genetics, particularly elevated lipoprotein(a), in stubborn plaque buildup. His guidance emphasizes practical strategies like targeted fat choices, fiber intake, and realistic exercise plans to help reduce risk and prevent further progression. Quotes to ponder: "The trouble is, once this plaque, or atherosclerosis, sets in, it's not reversible through lifestyle alone." "It's estimated that about 1 in 5 Americans have high levels of lipoprotein-a." "Fiber is so helpful because it binds to cholesterol and helps the body get rid of it." Episode references: Omega-3 Fatty Acids – NIH Office of Dietary Supplements: https://ods.od.nih.gov/factsheets/Omega3FattyAcids-Consumer/ Learn more about your ad choices. Visit megaphone.fm/adchoices

Discover all of the podcasts in our network, search for specific episodes, get the Optimal Living Daily workbook, and learn more at: OLDPodcast.com. Episode 3308: Dr. Neal Malik explains why atherosclerosis can persist even with statins, diet, and lifestyle changes, highlighting the role of genetics, particularly elevated lipoprotein(a), in stubborn plaque buildup. His guidance emphasizes practical strategies like targeted fat choices, fiber intake, and realistic exercise plans to help reduce risk and prevent further progression. Quotes to ponder: "The trouble is, once this plaque, or atherosclerosis, sets in, it's not reversible through lifestyle alone." "It's estimated that about 1 in 5 Americans have high levels of lipoprotein-a." "Fiber is so helpful because it binds to cholesterol and helps the body get rid of it." Episode references: Omega-3 Fatty Acids – NIH Office of Dietary Supplements: https://ods.od.nih.gov/factsheets/Omega3FattyAcids-Consumer/ Learn more about your ad choices. Visit megaphone.fm/adchoices

Heart disease should be treated just like cancer, says guest Mike McConnell, an author and expert in preventive cardiology at Stanford: Detect and stage early, then treat aggressively. In his practice, McConnell focuses on using low-dose CT imaging for detecting early coronary artery disease. He also helped pioneer the use of AI to infer cardiovascular risk from retinal scans. Such non-invasive, consumer-friendly tools could expand prevention, personalize therapy, and cut heart attacks and strokes across the board, he says. “Everybody also deserves a proactive preventive cardiologist in their phone,” McConnell tells host Russ Altman of the latest approaches to heart disease on this episode of Stanford Engineering's The Future of Everything podcast. Have a question for Russ? Send it our way in writing or via voice memo, and it might be featured on an upcoming episode. Please introduce yourself, let us know where you're listening from, and share your question. You can send questions to thefutureofeverything@stanford.edu. Episode Reference Links: Stanford Profile: Michael V. McConnell, MD, MSEE Connect With Us: Episode Transcripts >>> The Future of Everything Website Connect with Russ >>> Threads / Bluesky / Mastodon Connect with School of Engineering >>> Twitter/X / Instagram / LinkedIn / Facebook Chapters: (00:00:00) Introduction Russ Altman introduces guest Michael McConnell, a professor of cardiology at Stanford University. (00:03:02) Reframing Heart Disease Why coronary disease should be approached the same as cancer. (00:05:46) Core Risk Factors The key drivers of cardiovascular disease, and life's essential eight. (00:07:18) Coronary Artery Calcium Scoring How low-dose CT scanning detects disease before symptoms develop. (00:08:57) The Limits of Stress Testing Why traditional stress tests often miss early coronary disease. (00:10:18) AI in Cardiac Imaging Using AI to identify hidden risks in routine chest scans. (00:11:30) Retinal Imaging How AI analysis of retinal blood vessels can predict heart disease risk. (00:14:55) Detecting Risk Before Symptoms Why retinal and vascular changes occur long before clinical signs appear. (00:15:58) Staging Coronary Disease Using calcium scores to stage coronary disease and personalize treatment. (00:19:36) Direct-to-Consumer Prevention The rise of mobile health records, wearable devices, and AI tools. (00:22:23) Opportunities & System Challenges Balancing accessibility, guideline-based care, and healthcare system capacity. (00:25:26) AI-Powered Health Record Analysis The potential of automated reviews to identify silent risk factors. (00:27:41) Physician Adoption & System Friction Barriers to integrating early detection tools into clinical practice. (00:30:12) Advances in Treatment Overview of current cholesterol therapies and plaque stabilization. (00:33:31) Future In a Minute Rapid-fire Q&A: prevention, implementation science, and future hopes. (00:35:38) Conclusion Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Vitamin D testing is vital for tailoring doses to optimize health—but regulators are conducting a campaign to deny coverage; Can magnesium be taken simultaneously with blood pressure meds? Lifelong learning delays Alzheimer's onset by 5 years; Your MRI says you have a bum shoulder—but 99% of people show abnormalities even when they have no discomfort; Saunas can help stave off dementia. 

Heart attacks aren't inevitable. Dr. Esselstyn shows how diet—not age—drives disease, and how plaque starts forming by age 17. #HeartReversal #PlantBasedHealing #PreventHeartAttacks #HealthTalks

Cardiologist's Mission to Prevent Heart Attacks; Patient Case: Fit 55-Year-Old With Severe Heart Disease; Early Signs of Atherosclerosis in Patient History; When and Why to Check Cholesterol Levels; How Cholesterol Moves Through the Body; Lipoprotein Classes and Size-Based Risk; Exogenous vs. Endogenous Cholesterol Pathways; Triglycerides Reflect Dietary Intake; Understanding HDL and Reverse Cholesterol Transport; LDL Density and Misleading Cholesterol Tests; Cholesterol Panel Limitations and Calculations #HeartHealth #Cholesterol #LifestyleMedicine #HealthTalks

Dr. Kahn calls for cancer-level attention to heart disease, citing death rates, hidden symptoms, and young-age fatalities. #HeartHealth #CardiacAwareness #PreventionMatters #SuddenDeath

ReferencesCell. 2020 Mar 12;180(6):1098–1114.e16. Atherosclerosis.2015 Aug;241(2):615-23Cancer Discov. 2020 May;10(5):OF7Clin Exp Metastasis. 2024 Aug;41(4):333-349J Immunotherapy Cancer. 2024 Dec 22;12(12):e009541Songs from 1926https://music.youtube.com/playlist?list=OLAK5uy_ll9BpKp7zZlbcRFC46YbuSo5SXAv-QW9Y&si=QEDBYPulz_CZ5yOJ

Dr. Williams and Dr. Kahn explore how ketogenic diets and saturated fats impact cardiovascular health and longevity. #KetogenicDiet #SaturatedFat #HeartHealth

What do you think of serrapeptase for reducing coronary plaque?We were told to get a TDAP vaccine or we wouldn't be able to see our new grandchild for 8 weeks!Do I have lupus?Which supplements tend to reduce negative effects of X-rays?

The Holiday Season in NYCPeanut allergies cause and effectWhich calcium supplements can I take if I'm allergic to cow protein?Can my husband take saw palmetto in lieu of his prostate medications?What do you think of traction to help bulging discs?What is your take on green powder supplements?

Popular media leverage weak study to criticize RFK Jr.'s rethink of standard recommendations for saturated fat avoidance; Poor quality plant-based diets hike cardio risk; A listener complains his lp(a) is going up with age despite his healthy diet, lifestyle; Scientists pinpoint cocoa ingredient that slows aging; Berry proanthocyanidins preserve brain power; Tattooing may promote inflammation, undermine immunity.

I was diagnosed with follicular lymphoma, but my symptoms may be caused by something else, per my oncologistI've been taking acidophilus and eating yogurt, but still have diarrhea for the last five months since taking a round of antibioticsThe consequences of antibiotic useMy carotid artery intima-media thickness shows higher than normal thickness. Should I be concerned?

The benefits of sauna and sunlight during winter monthsApplied Behavioral Analysis in autism treatmentWhat are good supplements to take for HPV virus?

A client has a very traumatic experience with their kidney transplant surgery in 2017. Ever since, they have lived with chronic, intractable neck and head pain that doesn't respond to any treatment they've tried so far. A recent CT scan reveals some calcium deposits inside the cranium but - is that the cause? Can massage therapy help? Are there any options for this person? Resources: Anwar, Z. et al. (2011) "Superficial temporal artery calcification in patients with end-stage renal disease: Association with vascular risk factors and ischemic cerebrovascular disease," The Indian Journal of Radiology & Imaging, 21(3), pp. 215–220. Available at: https://doi.org/10.4103/0971-3026.85371. CNN, C.S., Special to (2014) 'I couldn't move': Patients who wake up during surgery, CNN. Available at: https://www.cnn.com/2014/11/28/health/wake-up-during-surgery (Accessed: November 14, 2025). Healthcare, G.E. (2020) Waking Up During Surgery: A Nightmare | Clinical View. Available at: https://clinicalview.gehealthcare.com/article/waking-during-surgery-patients-worst-nightmare (Accessed: November 14, 2025). Kiroglu, Y. et al. (2009) "Intracranial calcifications on computed tomography: pictorial essay," Diagnostic and Interventional Radiology [Preprint]. Available at: https://doi.org/10.4261/1305-3825.DIR.2626-09.1. Li, Xuelong et al. (2022) "The association of renal impairment with different patterns of intracranial arterial calcification: Intimal and medial calcification," Atherosclerosis, 363, pp. 42–47. Available at: https://doi.org/10.1016/j.atherosclerosis.2022.11.012. Host Bio:              Ruth Werner is a former massage therapist, a writer, and an NCBTMB-approved continuing education provider. She wrote A Massage Therapist's Guide to Pathology, now in its seventh edition, which is used in massage schools worldwide. Werner is also a long-time Massage & Bodywork columnist, most notably of the Pathology Perspectives column. Werner is also ABMP's partner on Pocket Pathology, a web-based app and quick reference program that puts key information for nearly 200 common pathologies at your fingertips. Werner's books are available at www.booksofdiscovery.com. And more information about her is available at www.ruthwerner.com.      About our Sponsors:   Anatomy Trains is a global leader in online anatomy education and also provides in-classroom certification programs for structural integration in the US, Canada, Australia, Europe, Japan, and China, as well as fresh-tissue cadaver dissection labs and weekend courses. The work of Anatomy Trains originated with founder Tom Myers, who mapped the human body into 13 myofascial meridians in his original book, currently in its fourth edition and translated into 12 languages. The principles of Anatomy Trains are used by osteopaths, physical therapists, bodyworkers, massage therapists, personal trainers, yoga, Pilates, Gyrotonics, and other body-minded manual therapists and movement professionals. Anatomy Trains inspires these practitioners to work with holistic anatomy in treating system-wide patterns to provide improved client outcomes in terms of structure and function.                      Website: anatomytrains.com                        Email: info@anatomytrains.com             Facebook: facebook.com/AnatomyTrains                       Instagram: www.instagram.com/anatomytrainsofficial   YouTube: https://www.youtube.com/channel/UC2g6TOEFrX4b-CigknssKHA     

Send us a textToday we are releasing another bonus episode! This is my recent appearance on the IFixHearts YouTube Channel, hosted by Chris S. Cornell!As always, it was a fun chat, and I'm always so grateful to be a guest on someone else's show!Find I Fix Hearts by Dr. Ovadia at-YT- @I Fix Hearts by Dr. OvadiaFind Boundless Body at- myboundlessbody.com Book a session with us here!

Josh Wageman is a board-certified Clinical Lipid Specialist dedicated to transforming the way we understand and treat heart disease. With a deep expertise in cholesterol, metabolic health, and cardiovascular risk, he helps patients cut through the noise and take control of their health using evidence-based, personalized strategies. Known for translating complex science into actionable steps, Josh is passionate about prevention and proving that heart disease doesn't have to be inevitable. In this episode, Dr. Brian and Josh talk about… (00:00) Intro (00:32) Josh's interesting and varied career path (04:31) Understanding cardiovascular disease in a nutshell (8:15) Understanding lipoproteins (10:10) Why lipids are controversial and what we can all agree on (12:28) LDL and HDL particles (19:35) Endurance athletes and coronary calcium (29:54) Atherosclerosis, carnivore, and gut dysbiosis (39:46) Advanced lipid panels (40:29) Statins and LDL (44:13) Pros and cons of statins (49:54) Supplements that may be helpful for cardiovascular health (52:44) Rapping and singing about lipids and heart health (55:09) Science and faith; physical health and spiritual health (01:02:25) Outro For more information, please see the links below. Thank you for listening! Links: Please consider supporting us on Patreon: https://www.lowcarbmd.com/ Josh Wageman: IG: https://www.instagram.com/wagemanjosh/ Book: https://www.amazon.com/Security-System-Lipid-Neighborhood-Complicating/dp/B0DTJ1HJ4Y Dr. Brian Lenzkes:  Website: https://arizonametabolichealth.com/ Twitter: https://twitter.com/BrianLenzkes?ref_src=twsrc^google|twcamp^serp|twgr^author Dr. Tro Kalayjian:  Website: https://www.doctortro.com/ Twitter: https://twitter.com/DoctorTro Instagram: https://www.instagram.com/doctortro/ Toward Health App Join a growing community of individuals who are improving their metabolic health; together.  Get started at your own pace with a self-guided curriculum developed by Dr. Tro and his care team, community chat, weekly meetings, courses, challenges, message boards and more.  Apple: https://apps.apple.com/us/app/doctor-tro/id1588693888  Google: https://play.google.com/store/apps/details?id=uk.co.disciplemedia.doctortro&hl=en_US&gl=US Learn more: https://doctortro.com/community/ 

In this episode, I sit down with Dr. Rupy Aujla, an NHS GP and the founder of The Doctor's Kitchen, an app that includes doctor-approved recipes to cook at home. In this conversation, we dive into why cardiovascular disease remains the #1 killer worldwide, the connection between cholesterol and heart health, how fiber acts as a “magical nutrient” for the body, how to introduce it into your daily meals, and the role of lifestyle choices in preventing illness and supporting long-term brain and heart health. *** About Dr. Rupy Aujla: After suffering a significant heart condition, he dove deep into the science of nutritional medicine and was able to reverse his condition through food and lifestyle. In 2015, he launched The Doctor's Kitchen as a way to teach people how to cook their way to better health and to showcase the medicinal effects of eating well. The incredible “Doctor's Kitchen” cooking app has over 1000 delicious, science-backed recipes and 20 brand new ones added each month. There's also a handy meal planner that will personalise recipes based on your preferences. It actually suggested a delicious looking salmon poached in harissa coconut sauce, and  olive and date braised chicken, which suit my personal dietary needs and all sound great. You can download and use the app completely for free using this link. *** Subscribe to The Neuro Experience for more conversations at the intersection of brain science and performance. I'm committed to bringing you evidence-based insights that you can apply to your own health journey. *** A huge thank you to my sponsors for supporting this episode. Check them out and enjoy exclusive discounts: David's Protein: Buy four cartons and get your fifth one completely free | Head to https://davidprotein.com/pages/neuro Ketone IQ: Go to https://ketone.com/NEURO for 30% OFF your subscription order + receive a free gift with your second shipment. FIGS: You can get 15% off your first order at https://wearfigs.com with the code FIGSRX. Caraway: https://caraway.com/neuro for an additional 10% off your purchase MUDWTR: The coffee alternative. If you're ready to ditch the crash and sip smarter, go to https://mudwtr.com and use code NEURO to get 43% off + free shipping. *** I'm Louisa Nicola — clinical neuroscientist — Alzheimer's prevention specialist — founder of Neuro Athletics. My mission is to translate cutting-edge neuroscience into actionable strategies for cognitive longevity, peak performance, and brain disease prevention. If you're committed to optimizing your brain — reducing Alzheimer's risk — and staying mentally sharp for life, you're in the right place. Stay sharp. Stay informed. Join thousands who subscribe to the Neuro Athletics Newsletter → https://bit.ly/3ewI5P0 Instagram: https://www.instagram.com/louisanicola_/ Twitter : https://twitter.com/louisanicola_ *** Topics: 00:02:43: Lipid panels & overlooked markers 00:05:21: Atherosclerosis explained 00:08:13: Misleading “normal” cholesterol panels 00:10:48: Why heart disease remains #1 killer & prevention timeline 00:12:51: Cholesterol & Alzheimer's; LDL targets for brain health 00:15:12: Cholesterol causality, very low LDL safety 00:19:23: Statins & pharmacological interventions 00:26:02: Ultra-processed foods & saturated fats 00:29:26: Fiber's role in lowering LDL 00:32:05: How fiber binds bile acids & removes cholesterol 00:33:29: Gut microbiome & short-chain fatty acids from fiber 00:35:05: Lowering ApoB, LDL by eating plant-rich foods, portfolio diet 00:37:15: Oats & heart health 00:41:51: Pesticides in fruits and vegetables 00:45:37: Eggs and cholesterol 00:48:18: Soy 00:53:55: Balanced eating 00:57:40: Stress, sleep & cardiovascular disease 00:59:55: Memorable patient stories, family member with stent 01:04:04: How to reduce risk of heart attack or stroke with diet Learn more about your ad choices. Visit megaphone.fm/adchoices