Podcasts about metronomic

Big BIG BIG sounds on this week's Independent Music Podcast. A generally iffy week personally means that beers have been drunk and the music is beyond reproach.  Metronomic krautrock feeds to immense synth dungeon dance floor sounds, grime from living legend Manga Saint Hilare, and uncategorisable music from Ziúr on Uganda's Hakuna Kulala label.  Beyond that, deep house, Japanese footwork, Russian anti-war folk songs, and a triumphant return for the superb Selvhenter showcase the very best in global experimental sounds. You can listen to the first six tracks for free. To listen to the full episode, get a huge back catalogue of music, and access to our live shows and Discord group, please join our Patreon: patreon.com/independentmusicpodcast. The podcast only survives with Patron support TracklistingMEMORIALS – Blue Feather Boa (The State51 Conspiracy, UK)Solo Ansamblis & Roe Deers – SLIDU (Good Skills, Lithuania)Manga Saint Hilare x Blay Vision – Nothing Aint Free (self-release, UK)Ziúr – Eyeroll feat Elvin Brandhi (Hakuna Kulala, Uganda)Selvhenter – Anker (Eget Værelse, Denmark / Hands in the Dark, France)K-LONE – Love Me A Little (Wisdom Teeth, UK)Meursault – Meursault (Wasted State, UK)Oyubi – 4×4 Saxo (self-release, Japan)Pere Ubu – Crocodile Smile (Cherry Red Records, UK)Arkadiy Kots Band – Partisan | Complaint du Partisan | И с п о в е д ь п а р т и з а н а (self-release, Russia) This week's episode is sponsored by The state51 Conspiracy, a creative hub for music. Head to state51.com to find releases by JK Flesh vs Gnod, Steve Jansen, MrUnderwSood, Wire, Ghost Box, Lo Recordings, Subtext Records and many more Produced and edited by Nick McCorriston.

What is a soft tissue sarcoma? Soft tissue sarcomas are a broad category of tumors including those that arise from the connective, muscle, or nervous tissues in dogs and cats. These tumors are the result of abnormal production of these cell types in an uncontrolled manner. Connective, muscle, and nervous tissues are present throughout the entire body; therefore, these tumors can develop over the chest, back, side, legs, and facial tissues of your pet. Soft tissue sarcomas make up about 15% of cancers of the skin affecting dogs and about 7% of those affecting cats. Fibrosarcomas are common in dogs and are a type of soft tissue sarcoma (see handout "Fibrosarcoma in Dogs" for more information). "Soft tissue sarcomas make up about 15% of cancers of the skin affecting dogs and about 7% of those affecting cats." Even though soft tissue tumors arise from many different types of cells, they all behave in a similar manner and their treatment is typically the same. What causes soft tissue sarcomas? The reason why a particular pet may develop this, or any tumor or cancer, is not straightforward. Very few tumors and cancers have a single known cause. Most seem to be caused by a complex mix of risk factors, some environmental and some genetic or hereditary. For most cases of soft tissue sarcomas, no direct cause has been determined for their development. Sarcomas at injection sites occur in cats but are rare in dogs (see handout “Post-Vaccination Sarcoma in Cats” for further information on this type of sarcoma). In cats exposed to a form of the feline leukemia virus (called feline sarcoma virus), the development of sarcomas on the head and neck sometimes occurs. What are the clinical signs of soft tissue sarcomas? The clinical signs depend on where the tumor is located and the tissues that are affected. Often, pets have a noticeable mass that is growing in size. Signs associated with soft tissue sarcomas include the following: Pets that have tumors arising from muscle tissue may show signs of pain in the affected region and may have a distinct firm and growing mass (tumor). Tumors that are located on the limbs may cause changes in your pet's ability to walk and the limbs may have obvious swelling. Pets that have tumors arising from nervous tissue may be unable to use the affected limb or may show other neurological signs. Pets with intestinal tumors may have signs of an intestinal blockage, such as vomiting, diarrhea, lack of appetite, weight loss, and abdominal pain. Pets with soft tissue sarcomas in the mouth often have halitosis (bad breath), difficulty eating, loss of appetite, bleeding in the mouth, or obvious tumors in the mouth. Signs of a soft tissue sarcoma affecting the reproductive system depend on the location of the tumor. For example, if the prostate is affected, difficulty with urinating or defecating may be observed. How are soft tissue sarcomas diagnosed? In some cases, a fine needle aspiration (FNA) may be performed. FNA involves taking a small needle with a syringe to suction a sample of cells directly from the tumor and placing them on a microscope slide. A veterinary pathologist then examines the slide under a microscope. If a diagnosis is not confirmed by this method, a biopsy may be needed. A biopsy is a surgical excision of a piece of the tumor. Pieces of the tumor are then examined under the microscope. This is called histopathology. A biopsy is beneficial because it gives an indication as to how aggressive the tumor is and how its treatment should be approached. Staging (searching for potential spread to other locations in the body) may be recommended. This may include blood work, urinalysis, radiographs (X-rays) of the lungs, and possibly an abdominal ultrasound. If any lymph nodes are enlarged or feel abnormal, further sampling may be pursued to determine if any spread is present. "If any lymph nodes are enlarged or feel abnormal, further sampling may be pursued to determine if any spread is present." How do these tumors typically progress? This is entirely dependent on the location and grade of the tumor. Typically, the higher the grade (these tumors are graded from I to III) the more likely that spread is possible. However, one of the biggest concerns with soft tissue sarcomas is their ability to invade the local surrounding tissues. They can almost be described as an 'octopus', where the bulk of the tumor is the head and the microscopic cells that invade the surrounding tissue are like small tentacles. These ‘tentacles' become challenging to treat when managing your pet's tumor, either by surgery or radiation therapy. "...one of the biggest concerns with soft tissue sarcomas is their ability to invade the local surrounding tissues." What are the treatments for these types of tumors? The most commonly pursued treatment for all soft tissue sarcomas is surgery. Because these tumors typically produce ‘tentacles' of abnormal cells, wide margins (the amount of tissue that needs to be removed) must be obtained for the best control of the tumor. If microscopic cells are left behind after surgery, recurrence of the tumor is much more likely. If cells are left behind (determined through histopathology), either a second surgery or a combination of surgery and radiation therapy may be pursued. Chemotherapy is not usually pursued as a primary treatment unless surgery or radiation are not options for your pet based on the tumor size or location. Chemotherapy may be an option after surgery. Metronomic chemotherapy (daily administration of lower doses of chemotherapy rather than traditional schedules) may be recommended. These therapies will be discussed with you if they are relevant to your pet's particular type of sarcoma.

HT1179 - Metronomic Deadlines The backstory of my "Finding the Picture" series at LensWork Online and what it might offer as an inspirational strategy.

In Episode 50, Condo Vultures® podcast host Peter Zalewski discusses the latest real estate and economic news with veteran financial journalist Mike Seemuth and former business reporters John Fakler and Jean Gruss, principal with Gruss Communications.   In Segment 1, the panel discusses the latest COVID-19 statistics in Florida and South Florida and the following headlines:   1. "South Florida bars packed after Gov. gives OK for Phase 3 reopening" (WPLG 10 South Florida)   2. "‘Weekly jobless claims rise unexpectedly as stimulus boost fades" (CNBC)   In Segment 2, the panel discusses the following headlines: 3. "Miami's COVID budget passes with police layoffs, transformed NET and canceled events" (Miami Herald)   4. "Dezer's 30-acre megaproject in North Miami Beach gets first approval" (The Real Deal Miami)   5. "'Citing Covid-19 shutdown, Williams Sonoma and Pottery Barn want out of Lincoln Road" (The Real Deal Miami)   6. "Metronomic files for Chapter 11 bankruptcy" (South Florida Business Journal) In Segment 3, the panel of Zalewski, Seemuth, Gruss and Fakler make predictions about the South Florida real estate market and tricounty economy.    In Segment 4, Fakler reads out comments submitted by listeners and the panel responds.  To send a comment, please email the podcast at Inquiry@CondoVultures.com     Please be sure to patronize our advertising supporters: Condo Vultures® Realty, Condo Vultures® Condo Correction Tours, and CVR Realty.  Click here to subscribe to the Condo Vultures® Distressed Market Intelligent Report. --- Send in a voice message: https://anchor.fm/condovultures/message

"If you have something that someone hates or loves, you have something right?" Curt “KIRKEE B.” Bisquera has been highly active in the music industry for over thirty-years. He has recorded and/or toured with the likes of Johnny Cash, Carl Perkins, Sir Elton John, Mick Jagger, Morris Day and the Time, Pharrell Williams, and Tom Petty and the Heartbreakers and that is literally just scratching the surface. Curt is known as a “groove master” and in many ways it has become expected of him to deliver the groovy goods. Beyond simply drumming, Curt has been branching out recently with West Co. Pedals to create the “Grease Juicer”. Yes, a drummer is working together with a guitar pedal company. It goes to show that even the most top level drummers with an equally impressive resume still need to diversify in other areas to ensure a more comfortable career in music. In this conversation Curt opens up a lot about the changing music industry and what Curt likes and also doesn’t like about it. This episode focuses heavily on Curt’s observations of the industry over the last thirty years. Curt endorses DW Drums, Paiste, Vater, Remo, SKB, LP, Audio-Technica, Canopus, Jerry Harvey Audio, Big Fat Snare Drum, Tuner Fish Lug Locks, Big Bang Distribution, Slug Percussion, Randall May, Dauz, CRS.   You Will Hear About ... Why Curt released his own guitar pedal “Grease Juicer” and why he went in that direction instead of a drum product. Curt’s take on the drumming community vs the guitar community. Curt’s early days and beliefs on natural talent. Some first hand stories and thoughts about Jeff Porcaro. Our thoughts on the current state of social skills. Metronomic music and why we don’t like it very much. One of Curt’s mantras Personal advice and messages from Carl Perkins, Johnny Cash and Elton John. Curt’s thoughts on the music industry today compared to twenty years ago.   Why Should You Listen? Curt had asked me if he could listen to this episode prior to release to give it the seal of approval. The next day he responded with, “It’s good. It’s my truth.” I think that really sums this one up. Curt has had over thirty years of experience in this industry and has seen a lot of change. He isn’t entirely happy with the changes but he still loves music. You will hear his emotive explanation about how he has been under the microscope and beat detected in the studio for years. He is tired of that. He just wants to be free. To play music without a click. To have a recording truthfully represent what happened in the moment. To hear this from Curt was incredibly powerful. This episode is filled with truth. Curt’s truth. Whether you agree with it or not, this was a wonderfully unfiltered and organic conversation between two people who have a deep love for music.   Curt’s Socials Instagram Facebook Website   Follow ‘Drumeo Gab’ Instagram Facebook

Full article @ https://thesternmethod.com/virender-sodhi Dr Virender Sodhi was the first Ayurvedic and Naturopathic physician in the United States. From a young age, Dr. Sodhi knew he wanted to be a physician. This was a kid who would visit the village doctor and pretend he was ill so that he could take the prescribed medicine home, label it and add it to his growing “medicine cabinet”.  After moving to the United States, Dr Sodhi completed his ND degree at Bastyr University, Washington in 1988. The following year he founded the Ayurvedic and Naturopathic Clinic that he still practices at today.  It wasn’t until many years later, after dealing with cancer in his family, that Dr Sodhi turned his professional focus to oncology. Dr Sodhi completed a fellowship in Integrative Oncology with Dr. Mark Rosenberg in 2012 and a steady stream of cancer patients followed. Today he helps patients from around the globe using traditional Ayurvedic principles and integrative treatment protocols.  ***Resources Mentioned*** The Ayurvedic & Naturopathic Medical Clinic The Life of Jesus in India CoCurcumin Ayush Herbs Livit 2 Bacopa monnieri Ashwagandha Boswellia Serreta - Boswelya Plus Amla  Neem  Gotu Kola - Ayu-Dep by Ayush Herbs *** In This Episode: I’m really excited about this episode! I’ve interviewed a lot of different health professionals about cancer over the years but this is the first time I’ll be exploring Ayurveda. Ayurvedic medicine is the primary care model for hundreds of millions of people in India. Dr Sodhi talks me through what Ayurveda is and what makes it different from other Eastern medicine practices. We talk about some of the medicinal herbs used in Ayurvedic medicine – particularly the ones with anti-cancer properties, and how they can help patients as anti-cancer protocols and as integrative therapies alongside other alternative and/or conventional cancer treatments. Plus we’ll cover off where to find the best quality Ayurvedic herbs. Enjoy! Can you start with telling us what Ayurveda is? Ayurveda is thousands of years old. Deep-seated in Indian culture The ayurvedic philosophy to good health is to live in harmony with and follow the laws of nature Cancer is the prime example of what happens when we stray away from mother nature How did you get into medicine and in particular cancer? Born and raised in small rural village in Himalayas  His father was a school principal with a keen interest in medicine  Father taught him about plants and herbs and their medicinal properties Began collected herbs and medicines. Even feigned illness to his doctor so he could add what was prescribed to his collection When his father died of lung cancer, Dr Sodhi vowed to work in oncology. Didn’t happen until his sister was diagnosed with breast cancer years later Completed his fellowship in Florida with integrative oncologist Dr Mark Rosenburg Cancer patients started pouring in Why is there such an emphasis on herbs in Eastern medicine? Indian culture is very old and advanced in thinking Historically India was the learning academy for the world The Life of Jesus in India (YouTube video) - did Jesus go to India during the ‘missing years’ before return to Jerusalem? Consider the behaviour of animals - they look, sniff, taste and if they like it they eat it. We need to use our senses in the same way Close connection with mother nature is part of Indian culture Native American culture is rich in herbology Wild food foraging How is Ayurveda different from other practices? Mental, emotional, spiritual, physical - Ayurveda focuses on all these aspects Cancer patients often have mental or emotional issues Cancer is not one disease, group of many diseases Most diseases are a result of lifestyle Our food chain is contaminated, no safety data on chemicals in our environment We need to drive change by not purchasing these products  Pesticides killing our gut microbiome Do you provide the mental and emotional support? Assess and provide tools but refers to others for ongoing support Changing thought processes is key to long term health We must create balance every day  What Ayervadic herbs would people be familiar with? Turmeric and curcumin - helps with inflammation and changes gene behavior Dr Sodhi’s product - CoCurcumin Boswellia Serreta (Frankincense) - anti-inflammatory. Beneficial for neuroblastoma, bone cancers and sacommas Ashwagandha - adaptogen that helps the body balance itself. Anti-angiogenic effect - restricts blood supply to tumors Natural compounds have DNA and can communicate with the body. Synthetic drugs cannot  Natural compounds support the immune system Immunotherapy gaining popularity  Neem - antifungal, antibacterial, antiviral. Creates autophagy in cancer cells (cell starves) The immune system has the tools to fight cancer cells if it is working properly How is your turmeric product different Turmeric oils are not very bioavailable unless you add fat Golden milk is a drink with milk and turmeric Coconut milk contains medium chain triglycerides (MCTs) that help keep sugar away from cancer cells and make it more bioavailable CoCurcumin uses MCTs to significantly improve the bioavailability of curcumin. CoQ10 is added to support cardiovascular and inflammatory function.  Trikatu, a traditional Ayurvedic combination of piperine from black pepper is also added to enhance turmeric absorption. Metronomic approach to chemotherapy (micro / low dosing) is becoming more popular How do you design an anti-cancer herbal protocol? Ongoing learning process Every disease starts with the mind Looks at the whole picture  Food, digestion. Chew your food, eat mindfully, eat nutrient dense not calorie dense food We want quick fixes when it comes to our health, but never the answer Paleo dieters seem to have forgotten the gathering part from our hunter gather past Hunting was exercise Animals farm raised - changes composition of meat and fat Portions too large What are other go-to herbs for cancer? Guduchi (Tinospora cordifolia) Amla - immune booster, lowers cholesterol, good for digestion Ginger - destroys oncogenes, helps digestion Onion and garlic Eat raw to avoid destroying the active properties Bacopa monnieri - brain support Gotu Kola - collagen strengthen Eat local and seasonal Integrative use of Ayurveda with chemo Amla protects the heart Use ashwagandha alongside cyclophosphamide  Curcumin reduces side effects of chemotherapy  Livit-2 is a preparation of herbs that support the liver  In 12 years in oncology Dr Sodhi has not seen issues with combining the majority of herbs with chemotherapy Where do you go to get herbs? Need the best quality  Dr Sodhi grows and extracts himself Recommends +Metagenics, Xymogen Watch out for heavy metals in herbs Dr Sodhi’s herbal company - Ayush Herbs   Follow Dr Sodhi The Ayurvedic & Naturopathic Medical Clinic Facebook Youtube If you liked this episode, check out: The World’s Longest Living Cultures with Lowest Cancer Rates – What Can We Learn?: Jason Prall If you have a question or comment about this episode let us know below!!

New month. new EF Podcast! This time with an exclusive 2 hour Resident-Mix by Bek. which features latest and greatest from the club…and living room ;) The Mix also features Bek's latest production called "Metronomic" which has been released a few days ago. If you like it, feel free to get your copy! Enough bla bla, let's headover to the music: Playlist: 01. Dave DK - Nueva Cancion 02. Timo Maas, Basti Grub, Eric Volta - We Were Riding High (Rodriguez Jr. Remix) 03. Daniel Dubb & Jonathan Rosa - Embers 04. Oliver Lieb - Epoxi 05. Depaart - Blowing Smoke 06. Artbat - Papillon 07. Moonwalk - Fatima 08. M.A.N.D.Y. - Jah (Flashmob Remix) 09. Niconé - UHWII (Cut 2) 10. Dee Montero - Pangea (Future Dub) 11. Sideways - Retraced 12. Dusky - Amongst the Gods 13. Dominik Eulberg - Abendpfauenauge 14. Bek - Metronomic 15. Lanark Artefax - Touch Absence Get in touch with the DJ: www.facebook.com/BekNews www.instagram.com/dj__bek www.twitter.com/dj_bek www.soundcloud.com/bek-1

Dr Slavc talks to ecancertv at Children with Cancer UK’s workshop on Drug Delivery in Paediatric Brain Tumours in London, UK. In the interview she discusses the use of metronomic anti-angiogenic therapy in patients with relapsed brain tumours. Together with colleagues in Boston and several other European centres, Dr Slav is conducting a trial in children and young adolescents who have relapsed medulloblastoma. These patients have a very poor prognosis even when treated with conventional chemotherapy, high-dose chemotherapy with stem cell rescue, irradiation or combinations of all these approaches. The novel treatment regimen being tested in the trial consists of biweekly intravenous bevacizumab in combination with five oral drugs (thalidomide, celecoxib, fenofibrate, and alternating cycles of daily low-dose oral etoposide and cyclophosphamide). This is augmented with alternating courses of intrathecal etoposide and liposomal cytarabine.

Prof Berthold talks to ecancertv at the Metronomic Chemotherapy Meeting in Milan about the use of metronomic therapy in treating children with neuroblastoma.

Dr André talks to ecancertv at the Metronomic Chemotherapy meeting in Milan about the use of metronomic chemotherapy in frail and unfit patients, as well as its benefits as an orally administered treatment. and one that is cost-effective for low-income countries. In particular, he discusses the aims and work of the Metronomic Global Health Initiative. In addition, he notes the strides being made in drug repurposing.

Dr Sterba talks to ecancertv at the Metronomics in Chemotherapy Meeting in Milan about the benefits of metronomic therapy in treating neuroblastoma, including cost-effectiveness. In addition, he discusses the ways in which this approach can be combined with other treatment strategies such as immunotherapy.

Prof Shaked talks to ecancertv at the Metronomic Chemotherapy Meeting in Milan about the benefits of a metronomic chemotherapy regimen as a less aggressive treatment than high dose chemotherapy, and a more effective maintenance drug, preventing relapse and decreasing metastatic burden.

Prof Bocci talks to ecancertv at the Metronomic Chemotherapy Meeting in Milan about the benefits of metronomic treatment. He highlights the difficulties faced in trying to research such treatment in light of limited knowledge on the mechanics and biomarkers which make it work, as well as logistical difficulties, such as funding.

Prof Shripad Banavail talks to ecancer at the 2013 WIN Symposium about treating cancer patients in India, where most people do not have health insurance and have to pay for drugs out of their own pocket. This means most can not afford treatment which is the standard of care in wealthier countries. Metronomic therapy (repetitive low doses) can help with this situation; moving away from newer drugs towards 'drug repositioning'; using older cheaper targeted drugs alongside chemotherapy - often 3 in combination that target: 1) the tumour itself 2) the tumour microenvironment including angiogenic effect 3) the body's own immunity

In the present study the mechanisms leading to acquired chemoresistance, as well as new treatment strategies implying the prevention evading of tumor cells were addressed. Resistance formation is one of the major hurdles in cancer therapy. Metronomic antiangiogenic treatment of xenografted prostate cancer tumors in mice with cyclophosphamide (CPA) results in the appearance of resistant tumors. To investigate the complex molecular changes occurring during resistance formation, a comprehensive gene expression analysis of the resistant tumors in vivo was performed. A multitude of differentially expressed genes, e.g. PAS domain containing protein 1 (PASD1), annexin A3 (ANXA3), neurotensin (NTS) or plasminogen activator tissue (PLAT), were observed, when comparing resistant to in vivo passaged tumor samples. Moreover, tumor cells from in vivo and in vitro conditions showed a significant difference in target gene expression. For clarification of the mechanisms leading to the survival of tumor cells during maintained anti-angiogenic CPA therapy the differentially expressed genes were assigned to functional pathways like: axon guidance, steroid biosynthesis and complement and coagulation cascades. As blood flow might play a crucial role during maintained anti-angiogenic therapy, further analysis was focused on the genes grouped in complement and coagulation cascades. pregulation of anti-coagulatory ANXA3 and PLAT and downregulation of SERPIN A1 and other SERPIN-family members was shown by qPCR analysis. In contrast coagulation factor F3 was upregulated, accompanied by the expression of an altered gene product. Taken together, a potential role of anticoagulation as a resistance mechanism for anti-angiogenic CPA therapy could be described. Furthermore, the role of archazolid, a novel myxobacterial V-ATPase inhibitor in cancer treatment and in particular its action on the secreted cellular proteome was evaluated. As extracellular protein secretion may have an impact on invasive properties of tumor cells, the changes of the secretome profile of highly migratory urinary bladder carcinoma cells upon archazolid treatment were analyzed. An induced secretion of prometastatic lysosomal proteins such as the cathepsin family was observed. Interestingly, intracellular cathepsin B activity however strongly decreases and mature cathepsin B protein diminishes. It could be shown that archazolid inhibits the mannose-6-phosphate receptor mediated trafficking of procathepsin B from the trans-Golgi network to prelysosomal compartments, leading to an impaired cathepsin B maturation process. This results in an unnatural secretion of the inactive proenzyme and a dramatic decrease in intracellular cathepsin B activity. Importantly, also in vivo an archazolid induced reduction of cathepsin B activity was proven and archazolid treatment resulted in a reduced formation of distant metastases in the lungs. In summary these results indicate that archazolid in addition to its known anti-migratory properties might exert an anti-metastatic effect by reducing the activity of pro metastatic proteases like cathepsin B.

Tripawds Podcast Episode #18: Tune in for an informative discussion with Dr. Barbara Biller, Veterinarian and Assistant Professor of Oncology at Colorado State University Animal Cancer Center The primary focus of Dr. Biller’s research is on the interactions between the anti-tumor immune response and metronomic chemotherapy. Recently she completed a study for Morris Animal Foundation (MAF) in which she evaluated metronomic chemotherapy treatment on dogs with soft-tissue sarcoma. During the study, it was Dr. Biller’s mission to learn more specifics on how to treat dogs using metronomics. She says: “Even though veterinarians have been using metronomic chemotherapy on patients, we have been guessing on important factors like what drugs we should use, what dose is needed and at what intervals we should treat the patient. We hope to determine some of those factors.” Dr. Biller is also involved in a number of collaborative studies with investigators at the University of Colorado Cancer Center and the Garden State Cancer Center evaluating immunotherapies in dogs with lymphoma and brain tumors. Join us in the Tripawds Live Chat during the show! DISCLAIMER: Information provided at Tripawd Talk Radio and Tripawds.com is not a substitute for medical care by a qualified veterinary professional. Always seek the advice of a licensed veterinarian prior to making any medical decisions about your dog’s health. Tripawds.com is not responsible or liable, for any damages resulting from the use (or misuse) of information contained in or implied herein. Support the show (https://tripawds.com/support)