Podcasts about tumours

This National Brain Tumour Awareness Week, Brain Tumour Ireland is highlighting the symptoms of brain tumours in children and teenagers. Tumours of the brain and central nervous system are the most common childhood cancer, alongside leukaemia, but the symptoms can often be confused for other more common illnesses.Dr Sarah Curry, consultant neuro-oncologist at CHI Crumlin, and Cliona Leamy, mum to eight-year-old Izzy who was diagnosed with a brain tumour at the age of two, joined The Last Word to discuss the signs that can arise and the challenges some face in getting a diagnosis. Catch the full chat by pressing the 'Play' button on this page!

In today's episode, I'm joined once again by Dr. Steven A. Ross — historian, philosopher, and co-founder of the World Research Foundation. If you've ever explored his site lesscomplicated.net, you'll know it's a treasure trove of ancient wisdom, rare texts, and teachings that reach back thousands of years. We dive into a subject that has fascinated and divided people across cultures and centuries: miraculous, or what some call spontaneous, healing.   From documented medical records to historical accounts of healers who cured thousands through love alone, Dr. Ross brings forward examples that challenge the limits of what we think is possible. Our conversation explores the distinction between belief and faith, the ancient principle of 'know thyself,' and how love, laughter, and joy are not only emotional states but also catalysts for health.   We talk about the placebo effect, the power of expectation, and why the body — not medicine — is always the true healer. If you've ever wondered whether healing is simply mechanistic, or if there's a higher order of laws at play, this episode will invite you to reconsider the nature of health, faith, and the untapped capacities of the human spirit.   Feelings with Strangers Socials Insta: https://www.instagram.com/feelings.with.strangers/ YouTube: https://www.youtube.com/@FeelingswithStrangers   Cited Texts Tumours Melt Like Snowballs "Psychological Variables in Human Cancer," Journal of Prospective Techniques 31 (1957), pp. 331-40. The Modern Bethesda   Steven Ross Site: https://www.lesscomplicated.net/

In this episode, Michael and Josh continue to unpick the thorny question of germ-cell tumours, focusing this week on more advanced and relapsed disease. Germ cell tumours have an excellent prognosis, but unfortunately there are cases where more intense therapy is required. Listen on to find out about what to do when first line therapy is not enough!Studies discussed in this episodeBEP - Williams et al (1987)TIP - Gleeson et al (20224)For more episodes, resources and blog posts, visit www.inquisitiveonc.comPlease find us on Twitter @InquisitiveOnc!If you want us to look at a specific trial or subject, email us at inquisitiveonc@gmail.comArt courtesy of Taryn SilverMusic courtesy of AlisiaBeats: https://pixabay.com/users/alisiabeats-39461785/Disclaimer: This podcast is for educational purposes only. If you are unwell, seek medical advice.Oncology for the Inquisitive Mind is recorded with the support of education grants from our foundation partners Pfizer, Gilead Pharmaceuticals and Merck Pharmaceuticals. Our partners have access to the episode at the same time you do and have no editorial control over the content. Hosted on Acast. See acast.com/privacy for more information.

This episode is the first of a two-part mini-series where Michael and Josh attempt to untangle the complex topic of germ cell tumours, an area that requires specialist experience and a high-volume multi-disciplinary centre to treat adequately. Or, you could just listen to Oncology for the Inquisitive Mind and be a pro in no time!Studies discussed in this episodeEORTC-30982de Wit et al (2001)For more episodes, resources and blog posts, visit www.inquisitiveonc.comPlease find us on Twitter @InquisitiveOnc!If you want us to look at a specific trial or subject, email us at inquisitiveonc@gmail.comArt courtesy of Taryn SilverMusic courtesy of AlisiaBeats: https://pixabay.com/users/alisiabeats-39461785/Disclaimer: This podcast is for educational purposes only. If you are unwell, seek medical advice.Oncology for the Inquisitive Mind is recorded with the support of education grants from our foundation partners Pfizer, Gilead Pharmaceuticals and Merck Pharmaceuticals. Our partners have access to the episode at the same time you do and have no editorial control over the content. Hosted on Acast. See acast.com/privacy for more information.

“I'm not living the life I thought I would—but I *am* living. I'm no longer just existing. It's hard. It's painful. But it's real. This is my reality.”Nothing in my life feels "normal." There's no roadmap. Just the cards I've been dealt—and I'm learning to play them, even when the deck feels stacked against me.I've faced adversity that's shaped me into the person I am today. One moment that really stands out is being dismissed by a doctor when I raised concerns about breast cancer. That experience taught me a powerful lesson: "your gut is gold". You have to trust it—even when others won't listen.Key TakeawaysListen to your gut — It's there for a reason. Don't silence it to keep others comfortable.Take note of who shows up— When the sh*t hits the fan, you learn who's truly in your cornerBe your own advocate — Doctors are not gods. You know your body better than anyone."You do you” in health battles — There is no one-size-fits-all. Do what you need to survive, heal, or just make it through the day.Existing vs. Living — There's a world of difference. I've learned that choosing to "live"—even if it's messy or painful—is worth everything.allaboutyoupodcast@yahoo.comhttps://www.youtube.com/@allaboutyoupodcast2505

Changsong Qi joins Chloe Wilson and Ben Abbott of The Lancet to discuss their recently published phase 2 randomised controlled trial investigating Claudin-18 isoform 2-specific CAR T-cell therapy for previously treated advanced gastric or gastro-oesophageal junction cancer.Read the full article:https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)00860-8/fulltext?dgcid=buzzsprout_icw_podcast_May_25_lancetContinue this conversation on social!Follow us today at...https://thelancet.bsky.social/https://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

In this episode of the Onc Now Podcast, host Jonathan Sackier is joined by Joan Carles, Head of Section for the Genitourinary, Central Nervous System, Sarcomas and Tumours of Unknown Origin Unit at Vall d'Hebron University Hospital. Carles discusses breakthroughs in genitourinary cancer and sarcoma treatment, including anti-angiogenic therapies, overcoming resistance, and the role of genetic polymorphisms in personalised medicine.  Timestamps:     00:00 – Introduction   01:56 – Anti-angiogenic therapies  05:03 – Treatment resistance  07:53 – Genetic polymorphisms  09:02 – Sarcoma treatments  11:16 – Novel drugs  15:22 – Oncology societies  18:00 – Carles' three wishes for healthcare 

Talk 1: A/Prof Pratiti (Mimi) Bandopadhayay, Dana Farber Cancer Institute: Emerging precision oncology in brain tumoursTalk 2: Dr Frank Lin, UNSW: Integrating IT tools into trials of precision oncology

Marion Edmunds, Carte Blanche producer spoke to Clarence Ford about their new Carte Blanche investigation into MPA/ Depo-Provera and sphenoid wing meningiomasSee omnystudio.com/listener for privacy information.

Andrew is joined by very special guest, neuroradiolgist Frank Gaillard, for a chat about posterior fossa tumours and his latest brain tumour course. Topics include ependymoma, choroid plexus papilloma,  medulloblastoma, pilocytic astrocytoma, haemangioblastoma and more!  Posterior Fossa Tumour Course ► https://radiopaedia.org/courses/posterior-fossa-tumours-learning-pathway Radiopaedia 2025 Virtual Conference ► https://radiopaedia.org/courses/radiopaedia-2025-virtual-conference Become a supporter ► https://radiopaedia.org/supporters Get an All-Access Pass ► https://radiopaedia.org/courses/all-access-course-pass Radiopaedia Community chat ► http://radiopaedia.org/chat Ideas and Feedback ► podcast@radiopaedia.org   The Reading Room is a radiology podcast intended primarily for radiologists, radiology registrars and residents. 

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME information, and to apply for credit, please visit us at PeerView.com/HKW865. CME credit will be available until January 31, 2026.Finding the Heat in Cold Tumours: Potential for Perioperative Immunotherapy Strategies in Early Breast Cancer In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME information, and to apply for credit, please visit us at PeerView.com/HKW865. CME credit will be available until January 31, 2026.Finding the Heat in Cold Tumours: Potential for Perioperative Immunotherapy Strategies in Early Breast Cancer In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME information, and to apply for credit, please visit us at PeerView.com/HKW865. CME credit will be available until January 31, 2026.Finding the Heat in Cold Tumours: Potential for Perioperative Immunotherapy Strategies in Early Breast Cancer In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME information, and to apply for credit, please visit us at PeerView.com/HKW865. CME credit will be available until January 31, 2026.Finding the Heat in Cold Tumours: Potential for Perioperative Immunotherapy Strategies in Early Breast Cancer In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME information, and to apply for credit, please visit us at PeerView.com/HKW865. CME credit will be available until January 31, 2026.Finding the Heat in Cold Tumours: Potential for Perioperative Immunotherapy Strategies in Early Breast Cancer In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME information, and to apply for credit, please visit us at PeerView.com/HKW865. CME credit will be available until January 31, 2026.Finding the Heat in Cold Tumours: Potential for Perioperative Immunotherapy Strategies in Early Breast Cancer In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME information, and to apply for credit, please visit us at PeerView.com/HKW865. CME credit will be available until January 31, 2026.Finding the Heat in Cold Tumours: Potential for Perioperative Immunotherapy Strategies in Early Breast Cancer In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME information, and to apply for credit, please visit us at PeerView.com/HKW865. CME credit will be available until January 31, 2026.Finding the Heat in Cold Tumours: Potential for Perioperative Immunotherapy Strategies in Early Breast Cancer In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc.Disclosure information is available at the beginning of the video presentation.

I am joined in this podcast by Christine Miskelly to discuss her experience of witnessing how a brain tumour manifested in her husband Ivor. Christine narrated the subtle symptoms that Ivor first manifested, such as poor planning, social withdrawal, excessive slowness, impassivity and easy distractibility. We also discussed how the brain tumour altered Ivor's personality, particularly reducing his empathy, and how it impacted on their relationship. The podcast also explores the shock of getting a brain tumour diagnosis for Ivor, but also how this brought them together to face the challenges ahead. We also discussed the brain biopsy and the treatment plan which included surgery and radiotherapy. Our conversation also explored Ivor's sad progression, his post-treatment initial improvement before the subsequent progression as he developed seizures, and as his scan showed further tumour growth. Christine explored the emotional turmoil she went through this period, and how family, friends, and the kindness of strangers helped her to cope. Her perspectives also included how the whole experience included finding beauty and love. Other themes we covered were Ivor's advance directive, his terminal decline in a care home, and the aftermath of his death. Christine did her first degree in Psychology at the University of Durham back in the 1970s, and the bulk of her career was spent teaching Psychology at A-level. In more recent years, she studied Consciousness and Transpersonal Psychology with the Alef Trust. She said supporting students through this period of their lives has been one of her great joys.

In this podcast I explore the diverse perspectives of brain tumours, from their pathology and clinical manifestations to their complications and management. The podcast discusses the common primary brain tumours, particularly highlighting the usually benign meningioma, and the typically aggressive glioblastoma. I illustrate these themes with such graphic illness memoirs as The Iceberg by Marion Coutts, All in My Head by Jessica Norris, and Difficult Gifts by Courtney Burnett. I also discussed secondary brain tumours using the illustrative memoir of Barbara Lipska titled The Neuroscientist Who Lost Her Mind. These memoirs helped to demonstrate the sinister and the subtle symptoms of brain tumours, their investigations, and their treatments – chemotherapy, radiotherapy and surgery. This theme also explored the risk factors for brain tumours, and their investigational treatments. I also explored the fascinating history of brain tumour surgery which chronicled the contributions of such pioneering neurosurgeons as William McEwan, Rickman Godlee and Victor Horsley, and I cited such accounts as that of Andrew Wickens titled A History of the Brain, and that of Michael Aminoff titled Victor Horsley.

From the elusive neuroendocrine tumours like Rathke's Cleft Cysts and pituitary gland tumours to the broader impacts these conditions have on daily life, we explore it all. Join us as we navigate through the complexities of the body's inner workings, discuss the latest medical research, and hear firsthand accounts from those on the front lines of their own medical journeys. Whether you're a medical professional, a patient, or simply curious about the oddities of human biology, The Mutation Station offers insights and inspiration for everyone. Tune in to discover more about the mysteries of the human body and the resilience of the human spirit.

Send us a textJoin us for part 2 of our excellent review of high grade brain tumours with Professor Anthony Chalmers.We look at the role of PARPi and the challenges with new therapies in high grade gliomas.We discuss tumour treatment fields, vaccine trials and immunotherapy in brain tumours.We also hear Prof Chalmers wish list for helping advance research in brain tumours.We hope you enjoy!

Kathy Pritchard-Jones (University College London Great Ormond Street Institute of Child Health, London, UK) joins Ali Landman in conversation about tumour staging in childhood cancer, international standardisation of health data collection, and how to improve childhood cancer survival.Read the full article:https://www.thelancet.com/journals/lanchi/article/PIIS2352-4642(24)00302-X/fulltext?dgcid=buzzsprout_icw_podcast_generic_lanchiContinue this conversation on social!Follow us today at...https://twitter.com/thelancethttps://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

Send us a textJoin us today as we discuss high grade brain tumours with internationally recognised expert Professor Anthony Chalmers.Part 1 of 2 and we discuss implications of new molecular profiling on prognosis and treatment options in high grade brain tumours.We look at some recent changes in radiotherapy volumes and doses in brain tumours.We also discuss challenges in treatment of high grade brain tumours and the impact of steroids in high grade brain tumours alongside surgery, chemotherapy and radiotherapy.

Maurie Markman, MD - Testing Impacts Treatment: Applying Best Practices in HER2 Assessment in Solid Tumours

Maurie Markman, MD - Testing Impacts Treatment: Applying Best Practices in HER2 Assessment in Solid Tumours

Maurie Markman, MD - Testing Impacts Treatment: Applying Best Practices in HER2 Assessment in Solid Tumours

Simron Singh, MD, MPH - Addressing the Challenges of Treating Highly Proliferative Neuroendocrine Tumours: Review of the Latest Evidence

Simron Singh, MD, MPH - Addressing the Challenges of Treating Highly Proliferative Neuroendocrine Tumours: Review of the Latest Evidence

Ravi Ramjeesingh, MD, PhD, FRCPC - Immunotherapy for Biliary Tract Cancers: Changing the Narrative in Rare and Aggressive Tumours

Astrocytes are cells in the central nervous system crucial for supporting neurones and their function. A glioblastoma is a dangerous, rapidly growing type of brain tumour. Guess how they are linked.  

Have you ever heard of a genetic condition called neurofibromatosis, also known as NF?It's one of the most common genetic disorders, affecting about 1 in 3000 people globally. NF causes different types of tumours to form in various parts of the body. Because so little is known about the condition, it's often misdiagnosed, or not diagnosed at all. UHN is home to the Elisabeth Raab Neurofibromatosis Clinic, the only adult NF clinic in Canada. We discuss the clinic and the exciting research happening in the field of NF. But, for many people living with the condition, the stigma is often as challenging as the illness. Featuring: Dr. Suganth Suppiah – Surgeon-scientist at UHN's Krembil Brain Institute and Assistant Professor at the University of Toronto. Dr. Suppiah also leads the nerve surgery program at the Elisabeth Raab Neurofibromatosis Clinic, Canada's only adult NF clinic, based at UHN.Dr. Ryan Thomas – Family physician and Clinical Associate who works with patients at the Elisabeth Raab Neurofibromatosis Clinic. Dr. Thomas lives with neurofibromatosis himself.Additional resources: Canadian first: UHN Opens Multidisciplinary Clinic on Genetic DisorderElisabeth Raab Accelerator of Science to End NeurofibromatosisNeurofibromatosis Ontario Dr. Gelareh Zadeh's lab – link to more info about the Elisabeth Raab Neurofibromatosis ClinicChildren's Tumour FoundationThe Your Complex Brain production team is Heather Sherman, Jessica Schmidt, Dr. Amy Ma, Kim Perry, Sara Yuan, Meagan Anderi, Liz Chapman, and Lorna Gilfedder.The Krembil Brain Institute, part of University Health Network, in Toronto, is home to one of the world's largest and most comprehensive teams of physicians and scientists uniquely working hand-in-hand to prevent and confront problems of the brain and spine, such as Parkinson's, Alzheimer's, epilepsy, stroke, spinal cord injury, chronic pain, brain cancer or concussion, in their lifetime. Through state-of-the-art patient care and advanced research, we are working relentlessly toward finding new treatments and cures.Do you want to know more about the Krembil Brain Institute at UHN? Visit us at: uhn.ca/krembilTo get in touch, email us at krembil@uhn.ca or message us on social media:Instagram - @krembilresearchTwitter - @KBI_UHNFacebook - https://www.facebook.com/KrembilBrainInstituteThanks for listening!

Bryan Choi - Assistant Professor of Neurosurgery at Harvard Medical School and Associate Director of the Centre for Brain Tumour Immunology and Immunotherapy at Mass General (Massachusetts General Hospital)

Andy Tudor thought be might be getting early onset dementia or having a stroke when he was eventually admitted to hospital. When he was told he had a huge 7cm tumour in his brain it was almost a relief, he tells Elizabeth and Julia in this episode released during Brain Tumour awareness month. Seven years ago Andy had life-saving neurosurgery to remove the growth. He is beating the statistics which show just 12% of adults diagnosed with a brain tumour survive after five years. Andy has since gone on to have an active role in raising awareness of brain tumours through volunteering and as the co-host of Let's Talk about Brain Tumours - a podcast run by the Brain Tumour Charity. Andy tells Elizabeth and Julia how his life feels more fulfilling now than before his brain injury but the worry of regrowth is always there and two years ago he had to have radiation when some was found on a routine scan. Andy talks about some of the symptoms he experienced and reveals some of his strategies for dealing with fatigue, one of which includes a can of baked beans! Listen to find out more. In this episode you will learn: Some of the key symptoms of a brain tumour in adults and children How humour can help in tough times Finding new purpose in life after brain injury Ways to deal with the process of grieving your old self and embracing new after brain trauma. Strategies for dealing with neuro-fatigue. Why a supportive family can help life you up and give you hope. Andy is the co-host of Let's Talk About Brain Tumours - run with the Brain Tumour Charity Connect with Andy on X @Meningioma_host You can listen to the episode we did with Andy and Sarah for Let's Talk About Brain Tumours, Life After Brain Injury On A Good Day Thank you for listening to On A Good Day! Please go back and catch up on any missed episodes. For a full recap of Elizabeth and Julia's stories, listen to episode #1: How Brain Injury Came Into Our Lives - And Changed Them Forever. Please share this podcast with others it will benefit and subscribe, rate and review to help make it more visible! We'd be so grateful! Connect with Us On Instagram @onagood.day and X (formally Twitter) @onagood_day And you can join our Facebook community too! Learn more about your ad choices. Visit megaphone.fm/adchoices

According to Cancer Australia's latest data, over 1,900 Australians received a diagnosis of brain cancer in 2023, positioning it as the ninth most prevalent cause of cancer-related fatalities in the country. In this podcast, Dr Bhaumik Shah, an oncologist in Melbourne, discusses brain tumours and cancer, addressing symptoms and available resources to aid those affected by this condition.

Paul Wheatley-Price, MBChB, MD - The Track to Better Outcomes: Identifying and Managing Patients With NTRK-Positive Solid Tumours

David McDermott discusses melanoma and renal data. We never get to bladder or lung.

This episode covers brain tumours.Written notes can be found at https://zerotofinals.com/medicine/neurology/braintumours/ or in the neurology section of the 2nd edition of the Zero to Finals medicine book.The audio in the episode was expertly edited by Harry Watchman.

Normand Blais, MD - Adjuvant Immunotherapy in Patients With Solid Tumours: Addressing Challenges With System Capacity in the Canadian Healthcare Setting

Join Professor Michael Solomon, Dr Kilian Brown and Dr Jacob Waller from Royal Prince Alfred Hospital in Sydney, Australia, for this special four part series on pelvic exenteration surgery for locally advanced and recurrent rectal cancer. Learn about these ultra-radical procedures which go beyond the traditional TME planes that we learn during surgical training, and into all compartments of the pelvis. Episode 3 outlines the radical technical approaches to posterior and laterally invasive tumours, including en bloc iliac vascular resection and reconstruction, as well as radical sacrectomy techniques. Each episode in this series features a different international guest surgeon. In episode 3, the RPA team are joined by Dr Oliver Peacock from the University of Texas MD Anderson Cancer Centre, USA. Technical descriptions and videos: Shaikh I, Holloway I, Aston W, Littler S, Burling D, Antoniou A, Jenkins JT; Complex Cancer Clinic St Mark's Hospital London. High subcortical sacrectomy: a novel approach to facilitate complete resection of locally advanced and recurrent rectal cancer with high (S1-S2) sacral extension. Colorectal Dis. 2016 Apr;18(4):386-92. doi: 10.1111/codi.13226. PMID: 26638828. https://pubmed.ncbi.nlm.nih.gov/26638828/ Brown KGM, Solomon MJ, Austin KKS, Lee PJ, Stalley P. Posterior high sacral segmental disconnection prior to anterior en bloc exenteration for recurrent rectal cancer. Tech Coloproctol. 2016 Jun;20(6):401-404. doi: 10.1007/s10151-016-1456-0. Epub 2016 Mar 21. PMID: 27000857. https://pubmed.ncbi.nlm.nih.gov/27000857/ Sutton PA, Solomon M, Sasidharan P, Lee P, Austin K. Abdominolithotomy sacrectomy for the management of locally recurrent rectal cancer: video vignette. Br J Surg. 2021 Aug 19;108(8):e257. doi: 10.1093/bjs/znab105. PMID: 34089593. https://pubmed.ncbi.nlm.nih.gov/34089593/ Drami I, Fletcher JA, Corr A, West MA, Aston W, Hellawell G, Burns EM, Jenkins JT. Total pelvic exenteration with 'high and wide' sacrectomy for recurrent rectal cancer: A video vignette. Colorectal Dis. 2022 Dec;24(12):1625-1626. doi: 10.1111/codi.16230. Epub 2022 Jul 18. PMID: 35730692. https://pubmed.ncbi.nlm.nih.gov/35730692/ References: Rajendran S, Brown KGM, Solomon MJ. Oncovascular surgery for advanced pelvic malignancy. Br J Surg. 2023 Jan 10;110(2):144-149. doi: 10.1093/bjs/znac414. PMID: 36427187. https://pubmed.ncbi.nlm.nih.gov/36427187/ Austin KK, Solomon MJ. Pelvic exenteration with en bloc iliac vessel resection for lateral pelvic wall involvement. Dis Colon Rectum. 2009 Jul;52(7):1223-33. doi: 10.1007/DCR.0b013e3181a73f48. PMID: 19571697. https://pubmed.ncbi.nlm.nih.gov/19571697/ Rogers AC, Jenkins JT, Rasheed S, Malietzis G, Burns EM, Kontovounisios C, Tekkis PP. Towards Standardisation of Technique for En Bloc Sacrectomy for Locally Advanced and Recurrent Rectal Cancer. J Clin Med. 2021 Oct 25;10(21):4921. doi: 10.3390/jcm10214921. PMID: 34768442; PMCID: PMC8584798. https://pubmed.ncbi.nlm.nih.gov/34768442/ van Kessel CS, Waller J, Steffens D, Lee PJ, Austin KKS, Stalley PD, Solomon MJ. Improving Surgical Outcomes in Pelvic Exenteration Surgery: Comparison of Prone Sacrectomy with Anterior Cortical Sacrectomy Techniques. Ann Surg. 2023 Jul 24. doi: 10.1097/SLA.0000000000006040. Epub ahead of print. PMID: 37485983. https://pubmed.ncbi.nlm.nih.gov/37485983/  ***Fellowship Application - https://forms.gle/5fbYJ1JXv3ijpgCq9*** Please visit https://app.behindtheknife.org/home to access other high-yield surgical education podcasts, videos and more.  If you liked this episode, check out our recent episodes here https://app.behindtheknife.org/listen

Brandon Sheffield, MD, FRCPC - Identifying Actionable Targets in Solid Tumours: The Importance of Comprehensive Genomic Profiling

This episode is hosted by Thomas Slavin, MD, FACMG, DABMD, a Chief Scientific Officer at HALO Precision Diagnostics  and features Laura Valle, PhD, a Principal Investigator, at the Catalan Institute of Oncology, IDIBELL. They discuss the position statement on the APC I1307K allele and its association with cancer predisposition which was generated by a multidisciplinary international expert group endorsed by the International Society for Gastrointestinal Hereditary Tumours (InSiGHT). Read our blog post "Evidence based guidance for APC I1307K and Cancer Risk" hereStay tuned for more podcasts in 2024! If you missed any of our earlier 2023 podcasts, you can find them here

Many of the guests on this podcast have emphasized the importance of awareness. Awareness of how we think can help improve how we think. Awareness of implicit bias can improve how we implement our true values. Awareness of emotions can improve how we react or don't react to different situations. I find awareness difficult to cultivate, and I have always admired Dr. Earl Glusac's ability to be present, calm, and steady. Dr. Glusac has been meditating regularly since 2005 (as well as when he was younger), and he shares his view on meditation as well as tips for a productive career in academic medicine. Dr. Earl J. Glusac, MD is a distinguished dermatopathologist and esteemed professor at Yale University School of Medicine. He has actively shaped the field through his roles on various medical board. He has served the American Boards of Pathology and Dermatology and the editorial boards of the Journal of Cutaneous Pathology and the American Journal of Dermatopathology; he was program director and president of the American Society of Dermatopathology, and he is an author for the World Health Organization's Classification of Tumours of the Skin. He attended Michigan State University for his medical degree, spent time in California for his residency training as well as dermatopathology fellowship, and has spent the majority of his dermatopathology career at Yale. Much of his research relates to the problem of overdiagnosis, especially as related to benign lesions that mimic malignant melanoma. 

Another quick bonus episode, this time to launch Frank's new enhancing brain tumours neuroradiology course - part 2 of his magnum opus. HALF PRICE this month (just $20) and free for All-Access Pass holders. A guided tour through 7 scrollable cases and 6 practice cases with related discussion and articles.  Enhancing Brain Tumours Course ► https://radiopaedia.org/courses/enhancing-brain-tumours-learning-pathway Become a supporter ► https://radiopaedia.org/supporters Get an All-Access Pass ► https://radiopaedia.org/courses/all-access-course-pass Andrew's Twitter ► https://twitter.com/drandrewdixon Frank's Twitter ► https://twitter.com/frankgaillard Ideas and Feedback ► podcast@radiopaedia.org   The Reading Room is a radiology podcast intended primarily for radiologists, radiology registrars and residents. 

Maori are disproportionately affected by brain tumours. Dr Thomas Park  using AI to scan a huge library of tumours collected from Maori and Pasifika patients to understand why.

How did the Ark of the Covenant end up in a cart with golden mice and tumours pulled by complaining milch cows? Well, there's quite a story there! Based on 1 Samuel 5:1-7:1. Show notes have been posted at retellingthebible.wordpress.com.   Media in this Episode The following music was used for this media project: Music: AhDah by Kevin MacLeod Free download: https://filmmusic.io/song/3345-ahdah License (CC BY 4.0): https://filmmusic.io/standard-license Artist website: https://incompetech.com Music: River of Io by Kevin MacLeod Free download: https://filmmusic.io/song/4296-river-of-io License (CC BY 4.0): https://filmmusic.io/standard-license Support Retelling the Bible If you would like to support the work that I do creating these stories, go to patreon.com/retellingthebible and choose a level of support!

With Christian Kollmannsberger

This week we've found ourselves attracted by the topic of magnetism; it's what makes it possible to generate and distribute electricity to our homes, or send messages and radio broadcasts over the airwaves; it underpins our ability to see inside the body with technologies like MRI scanners, and thanks to the fact that there's a massive magnetic field surrounding our planet, much of the radiation onslaught from space that would otherwise hit us is fended off, keeping the Earth habitable. That planetary magnetic field also provides us and animals with a way to navigate, and there are even... Like this podcast? Please help us by supporting the Naked Scientists

Cold exposure in mice activates brown fat to deny tumours glucose, and the future of extreme heatwaves. 00:45 How cold temperatures could starve tumoursA team of researchers have found that exposing mice to the cold could starve tumour cells of the blood glucose they need to thrive. They showed that the cold temperatures deprived the tumours of fuel by activating brown fat – a tissue that burns through glucose to keep body temperature up. The team also showed preliminary evidence of the effect occurring in one person with cancer, but say that more research is needed before this method can be considered for clinical use.Research article: Seki et al.08:59 Research HighlightsEvidence of the world's southernmost human outpost from before the Industrial Revolution, and how jumping up and down lets canoes surf their own waves.Research Highlight: Bones and weapons show just how far south pre-industrial humans gotResearch Highlight: How jumping up and down in a canoe propels it forwards11:24 The future of extreme heatwavesClimate scientists have long warned that extreme heat and extreme heatwaves will become more frequent as a result of climate change. But across the world these events are happening faster, and more furiously, than expected, and researchers are scrambling to dissect recent heatwaves to better understand what the world might have in store.News Feature: Extreme heatwaves: surprising lessons from the record warmth See acast.com/privacy for privacy and opt-out information.

Blueberry diet linked to lower breast cancer risk: New Zealand study Massey University (New Zealand), May 10, 2022 WELLINGTON (CIHAN)- Women might be able to reduce the risk of breast cancer by eating more blueberries, according to a New Zealand research. A Massey University study in which blueberries were fed to animals as part of their diet found they had a 50-percent lower incidence rate of mammary tumors. “Blueberries contain phytochemicals called anthocyanins, which may be responsible for the health benefits of blueberries,” Dr Janyawat Vuthijumnonk said in a statement. Tumours found in animals that received blueberries with fibre included (in pomace form), were smaller and less aggressive than in animals without blueberry consumption or in animals that received just blueberry juice.   “We also found circulating estrogen – the steroid hormone which plays a key role in breast cancer promotion – was lower in animals that consumed the blueberry pomace supplemented diet,” said Vuthijumnonk. Study finds that yoga and meditation can help minimize cognitive impairment UCLA, May 10, 2022 Inner peace and a flexible body may not be the most valuable benefits that yoga and meditation have to offer, suggests new research by a UCLA-led team of neuroscientists. The team found that a three-month course of yoga and meditation practice helped minimize the cognitive and emotional problems that often precede Alzheimer's disease and other forms of dementia—and that it was even more effective than the memory enhancement exercises that have been considered the gold standard for managing mild cognitive impairment. “Memory training was comparable to yoga with meditation in terms of improving memory, but yoga provided a broader benefit than memory training because it also helped with mood, anxiety and coping skills,” said Helen Lavretsky, the study's senior author. “Historically and anecdotally, yoga has been thought to be beneficial in aging well, but this is the scientific demonstration of that benefit,” said Harris Eyre, the study's lead author. “We're converting historical wisdom into the high level of evidence required for doctors to recommend therapy to their patients.” The researchers report that the participants' outward improvements in memory corresponded with perceptible changes in their brain activity. Using functional magnetic resonance imaging, they showed that subjects in both groups had changes in their brain connectivity, but the changes among the yoga group were statistically significant, whereas the changes in the memory group were not. Boost in nerve-growth protein helps explain why running supports brain health New York University, May 16, 2022 Exercise increases levels of a chemical involved in brain cell growth, which bolsters the release of the “feel good” hormone dopamine, a new study shows. Dopamine is known to play a key role in movement, motivation, and learning. Experts have long understood that regular running raises dopamine activity in the brain and may protect nerve cells from damage. In addition, past research has tied exercise-driven boosts in the dopamine-triggering chemical called brain-derived neurotrophic factor (BDNF) and in dopamine levels to improvements in learning and memory. However, the precise way these three factors interact has until now remained unclear.  Led by researchers at NYU Grossman School of Medicine, the investigation showed that mice running on a wheel for 30 days had a 40% increase in dopamine release in the dorsal stratium, the part of the brain involved in movement, compared to levels in mice that did not exercise. The runners also showed a nearly 60% increase in brain-derived neurotrophic factor (BDNF) levels compared to their non-running counterparts. Notably, the increase in dopamine release remained elevated even after a week of rest. Additionally, when BDNF levels were artificially reduced, running did not lead to additional dopamine release. “Our findings suggest that BDNF plays a key role in the long-lasting changes that occur in the brain as a result of running,” says study lead author and neurobiologist Guendalina Bastioli, Ph.D. “Not only do these results help explain why exercise makes you move, think, and feel better, they also show that these benefits continue even if you do not work out every day,” adds Bastioli. High levels of exercise linked to nine years of less aging at the cellular level Brigham Young University, May 10, 2022 Despite their best efforts, no scientist has ever come close to stopping humans from aging. Even anti-aging creams can't stop Old Father Time. But new research from Brigham Young University reveals you may be able to slow one type of aging—the kind that happens inside your cells. As long as you're willing to sweat. The study, published in the medical journal Preventive Medicine, finds that people who have consistently high levels of physical activity have significantly longer telomeres than those who have sedentary lifestyles, as well as those who are moderately active. Exercise science professor Larry Tucker found adults with high physical activity levels have telomeres with a biological aging advantage of nine years over those who are sedentary, and a seven-year advantage compared to those who are moderately active. To be highly active, women had to engage in 30 minutes of jogging per day (40 minutes for men), five days a week. High fruit intake during adolescence linked with lower breast cancer risk University of Oxford, May 11, 2022 A paper in The BMJ sheds new light on the relation of diet with breast cancer and heart disease. The study reports that high fruit consumption during adolescence may be associated with lower breast cancer risk. A team of US researchers wanted to see whether fruit and vegetable consumption might affect subsequent breast cancer risk. They followed 90,000 nurses for over 20 years who reported their diet in early adulthood, of whom half also recalled their usual diet during adolescence. They found that high fruit consumption during adolescence (2.9 v 0.5 servings per day) was associated with a roughly 25% lower risk of breast cancer diagnosed in middle age. In particular, greater consumption of apple, banana and grapes during adolescence, as well as oranges and kale during early adulthood was significantly associated with a reduced breast cancer risk.  Videos: 1. Jimmy Dore – Rachel Maddow's Non-Stop COVID Lies 2. Zach Weissmueller – Forget the Great Reset. Embrace the Great Escape. (8:43) (Zach is From Reason TV) 3. Implanted Microchip, Klaus Schwab, World Economic Forum and The Great Reset (Voice Over 2:25) 4.  Douglas Kruger –  “You will OWN NOTHING, and you will be HAPPY” (start @ 0:47) (interview with Douglas Kruger conducted by David Ansara of The Centre For Risk Analysis (CRA)