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Every hero needs three important tools. Today, I talk about the first one: the Flag (Own Your Results). The flag is what teens can use to stake a claim over their own results. Whether it's crappy or happy, if we take responsibility for it then we are more in control. -- Make sure you check out my new app, Sidekick to Hero! It's gamified mindset training for teens and it's about to launch soon. Go to www.sidekicktohero.com to get on the interest list.
At the ATP Finals in Turin, Italy, the story for two greats has gone in opposite directions. Rafael Nadal has been eliminated. Novak Djokovic remains in contention. Join Gill, Amy, and Joel as they explore what happened for each of these two this week, all on the latest episode of "Three -- A Show About Federer, Nadal, and Djokovic." Learn more about your ad choices. Visit megaphone.fm/adchoices
In this episode, you'll learn about why depending on results to keep you motivated ends up resulting in you giving up and three skills you can work on to help you become more consistent, resilient and self-compassionate. To download the mini training on obstacle anticipation mentioned in the episode, click here: https://bitesize.ck.page/1358d9ef81 To get your name on the list for the next round of The Confident Eater group coaching program click here: https://bitesize.ck.page/confidenteater To set up a call with me to learn more about coaching, click here: https://calendly.com/bitesizenutri/discoverycall If you're enjoying these episodes, make sure to leave a rating and/or review wherever you're listening, and give your favourite episode a share on social media (don't forget to tag me!) If you have a question or request for future episodes, please send me a DM on Instagram @bitesizenutri.. you have NO CLUE how much I love to hear from you!
This is a new "style" of episode that Dr. Kevin Richards from Univ of Illinois is hosting where he dives behind the research. This weeks guest is Dr. Michael Hemphill from UNC-Greensboro. Kevin and Michael discuss the article below: Hemphill, M. A., Janke, E. M., Flores, S., & Gordon, B. (2021). Conflict and harm in the context of restorative school physical education. Journal of Teaching in Physical Education, 41(1), 88-98. Here is the abstract of the article: Purpose: The purpose of this study was to explore the issues of conflict and harm in physical education within a school recognized for its exemplary restorative practices. Method: A single case study approach was employed to examine one restorative school in Wellington, New Zealand. The school was purposely selected to participate in this study based on its recognition for exemplary restorative practices. Participants included physical educators (n = 11), administrators (n = 4), and students (n = 25). Data sources included interviews, observations, and reflection documents. Data were analyzed using a collaborative qualitative approach. Results: Three qualitative themes described the context of restorative school physical education, types of harm that occurred, and how physical educators were positioned as central figures in creating a context where harm was addressed. Discussion: This study provides insights into restorative practices and has implications for teaching social and emotional learning skills. --- Support this podcast: https://anchor.fm/pwrhpe/support
Willem is joined in the co-hosts chair by former Victoria and Australia leg-spinner Bryce McGain to reflect on the passing of four great contributors to Australian cricket, and discuss the big issues to come out of the previous round of Shield action.The form of Marcus Harris, promise of Tanveer Sangha and incremental improvement of Tasmania all come under the microscope, as does Australia's form at the T20 World Cup after a humbling at the hands of England.
Every year, thousands of 12-year olds and their parents fret for days over a slip of paper they believe will seal their fate for the rest of their lives. But how much do Primary School Leaving Examination (PSLE) scores and academic achievement matter in the long run? Where does all the stress from PSLE come from? Lin Suling has a no-holds barred conversation with Rae Fung, Marvin Kang and Jonathan Teo on how their results shaped their journeys in life. See omnystudio.com/listener for privacy information.
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.28.317156v1?rss=1 Authors: Ma, Y., Yu, L., Olah, M., Smith, R., Oatman, S. R., Allen, M., Pishva, E., Zhang, B., Menon, V., Ertekin-Taner, N., Lunnon, K., Bennett, D. A., Klein, H.-U., De Jager, P. Abstract: INTRODUCTION: Not all APOE e4 carriers who survive to advanced age develop Alzheimer's disease (AD); factors attenuating the risk of e4 on AD may exist. METHODS: Guided by the top e4-attenuating signals from methylome-wide association analyze (N=572, e4+ and e4-) of neurofibrillary tangles and neuritic plaques, we conducted a meta-analysis for pathological AD within the e4+ subgroups (N=235) across four independent collections of brains. Cortical RNA-seq and microglial morphology measurements were used in functional analyses. RESULTS: Three out of the four significant CpG dinucleotides were captured by one principle component (PC1) which interacts with e4 on AD, and is associated with expression of innate immune genes and activated microglia. In e4 carriers, reduction in each unit of PC1 attenuated the odds of AD by 58% (OR=2.39, 95%CI=[1.64, 3.46], P=7.08E-6). DISCUSSION: An epigenomic factor associated with a reduced proportion of activated microglia appears to attenuate the risk of e4 on AD. Copy rights belong to original authors. Visit the link for more info
It's a little under three weeks until election day, and a Newshub-Reid Research poll released last night showed Labour could govern alone. But Labour leader Jacinda Ardern is not banking on a majority, because no New Zealand party has achieved one in an MMP election. The National Party landed at just under 30 per cent of the party vote in the new poll - but Judith Collins says its internal polling shows a different result. Deputy political editor Craig McCulloch speaks to Corin Dann.
Health Hero Show: The official Chemical Free Body Lifestyle Podcast
In this episode Tim James interviews Dr. John Jaquish from x3bar.com who is turning the fitness industry upside down. In his quest to pack muscle on himself Dr. Jaquish developed a specialized latex band workout system with a small olympic bar and ground plate. Results? Three times the muscle growth, NO injuries, NO soreness and it only takes 10-15 minutes per day! Mind blowing!!! Want to Boost your Testosterone Naturally? Go to www.ChemicalFreeBody.com and grab ALPHA DUDE Formula, it helps build your testosterone naturally without injections! For questions, to place an order or to book Tim for Podcasts, TV, Radio or Private Events email us at info@chemicalfreebody.com. Change Yourself…Change Your World! See omnystudio.com/listener for privacy information.
Background: The aim of this study was to compare two measures of depression in patients with schizophrenia and schizophrenia spectrum disorder, including patients with delusional and schizoaffective disorder, to conclude implications for their application. Sampling and Methods: A total of 278 patients were assessed using the Calgary Depression Scale for Schizophrenia (CDSS) and the Hamilton Depression Rating Scale (HAMD-17). The Positive and Negative Syndrome Scale (PANSS) was also applied. At admission and discharge, a principal component analysis was performed with each depression scale. The two depression rating scales were furthermore compared using correlation and regression analyses. Results: Three factors were revealed for the CDSS and HAMD-17 factor component analysis. A very similar item loading was found for the CDSS at admission and discharge, whereas results of the loadings of the HAMD-17 items were less stable. The first two factors of the CDSS revealed correlations with positive, negative and general psychopathology. In contrast, multiple significant correlations were found for the HAMD-17 factors and the PANSS sub-scores. Multiple regression analyses demonstrated that the HAMD-17 accounted more for the positive and negative symptom domains than the CDSS. Conclusions:The present results suggest that compared to the HAMD-17, the CDSS is a more specific instrument to measure depressive symptoms in schizophrenia and schizophrenia spectrum disorder, especially in acutely ill patients. Copyright (c) 2012 S. Karger AG, Basel
Background: Exhaled breath condensate (EBC) has been used for diagnosing and monitoring respiratory disorders. For clinical purposes the assessment of easy-to-obtain nonspecific markers seems particularly interesting. Objectives: As these measures are related to each other, our objective was to extract the independent information in global EBC markers across a range of respiratory disorders. Methods: EBC was collected from patients with asthma (n = 18), chronic obstructive pulmonary disease (n = 17), and cystic fibrosis (n = 46), as well as from lung transplant (LTX) recipients (n = 14) and healthy controls (n = 26). Samples were assessed for electrical conductivity, ammonia, pH, and nitrite/nitrate. pH was measured after both deaeration with argon and CO(2) standardization. Additionally, the fraction of exhaled nitric oxide (FE(NO)) was assessed. Factor analysis was applied to identify major factors concerning these measures. Results: Three independent factors were detected; the first comprised conductivity, ammonia, and pH, especially when standardized using CO(2), the second nitrite/nitrate, and the third FE(NO). Conductivity and ammonia were highly correlated (r = 0.968; p < 0.001). FE(NO) provided independent information mainly in asthma. The nonspecific EBC markers showed considerable overlap between patient groups and healthy subjects. However, conductivity, ammonia, pH standardized for CO(2) and nitrite/nitrate were increased in LTX recipients compared to healthy controls (p < 0.05 each). Conclusions: A panel of nonspecific easy-to-obtain exhaled breath markers could be reduced to 3 independent factors. The information content of conductivity, ammonia, and pH after CO(2) equilibration appeared to be similar, while FE(NO) was independent. The increased levels of these biomarkers in LTX might indicate a potential for their use in these patients. Copyright (C) 2010 S. Karger AG, Basel
Background: Problem-based Learning (PBL) has been suggested as a key educational method of knowledge acquisition to improve medical education. We sought to evaluate the differences in medical school education between graduates from PBL-based and conventional curricula and to what extent these curricula fit job requirements. Methods: Graduates from all German medical schools who graduated between 1996 and 2002 were eligible for this study. Graduates self-assessed nine competencies as required at their day-to-day work and as taught in medical school on a 6-point Likert scale. Results were compared between graduates from a PBL-based curriculum (University Witten/Herdecke) and conventional curricula. Results: Three schools were excluded because of low response rates. Baseline demographics between graduates of the PBL-based curriculum (n = 101, 49% female) and the conventional curricula (n = 4720, 49% female) were similar. No major differences were observed regarding job requirements with priorities for "Independent learning/working" and "Practical medical skills". All competencies were rated to be better taught in PBL-based curriculum compared to the conventional curricula (all p < 0.001), except for "Medical knowledge" and "Research competence". Comparing competencies required at work and taught in medical school, PBL was associated with benefits in "Interdisciplinary thinking" (Delta + 0.88), "Independent learning/working" (Delta + 0.57), "Psycho-social competence" (Delta + 0.56), "Teamwork" (Delta + 0.39) and "Problem-solving skills" (Delta + 0.36), whereas "Research competence" (Delta - 1.23) and "Business competence" (Delta - 1.44) in the PBL-based curriculum needed improvement. Conclusion: Among medical graduates in Germany, PBL demonstrated benefits with regard to competencies which were highly required in the job of physicians. Research and business competence deserve closer attention in future curricular development.
Background: SPG10 is an autosomal dominant form of hereditary spastic paraplegia (HSP), which is caused by mutations in the neural kinesin heavy chain KIF5A gene, the neuronal motor of fast anterograde axonal transport. Only four mutations have been identified to date.Objective: To determine the frequency of SPG10 in European families with HSP and to specify the SPG10 phenotype.Patients and methods: 80 index patients from families with autosomal dominant HSP were investigated for SPG10 mutations by direct sequencing of the KIF5A motor domain. Additionally, the whole gene was sequenced in 20 of these families.Results: Three novel KIF5A mutations were detected in German families, including one missense mutation (c.759G>T, p.K253N), one in frame deletion (c.768_770delCAA, p.N256del) and one splice site mutation (c.217G>A). Onset of gait disturbance varied from infancy to 30 years of age. All patients presented clinically with pure HSP, but a subclinical sensory--motor neuropathy was detected by neurophysiology studies.Conclusions: SPG10 accounts for approximately 3% of European autosomal dominant HSP families. All mutations affect the motor domain of kinesin and thus most likely impair axonal transport. Clinically, SPG10 is characterised by spastic paraplegia with mostly subclinical peripheral neuropathy.
Tierärztliche Fakultät - Digitale Hochschulschriften der LMU - Teil 01/07
Experimental investigations at the porcine over-sized coronary stent-model for in-stent-restenosis rate after implantation of uncoated niob-zirkonium stents and niob-zirkonium stents coated with iridiumoxide. Background: The treatment of atherosclerotic stenosis in coronary artery disease with balloon expandable coronary stents has been successfully practised in minimal invasive cardiology in the last two decades. Today almost all commercially coronary stents are made of stainless steel (316L) and there is a great variety in design and coatings available. Until now no interventional procedure has been successful to stop the vicious circle of arterial stenosis, intervention and restenosis. Methods: In 23 pigs (German land breed) Inflow Dynamics Starflex Design Stents were implanted into the LAD and LCX by random for 28 days. In the porcine over-sized coronary stent model three groups were compared: uncoated niob-zirkonium stents, niob-zirkonium stents coated with iridiumoxide and stainless steel stents (control group). The implantation procedure and angiography were documented and histological and histomorphometric studies were performed to interpret the in-stent-restenosis rate. The statistical evaluation of the differences between the test groups was done by the analysis of variance (One Way ANOVA-Test) and specified (Post Hoc-Test). Results: Three animals died postoperatively. 38 stents were evaluated. The implantation procedure in the experimental groups was complicated due to the elastic and plastic properties of the niob-zirkonium stents. The injury score (IS) and the measured neointimal area (NF) were significantly higher in the group of niob-zirkonium stents coated with iridiumoxide. The histomorphometric and angiographic parameters of restenosis did not point out any significant difference between the test groups. The histological response of the arterial wall after stent implanation provided a homogenous appearance of tissue shaped by the score of vascular irritation. Conclusion: A direct comparison in the stents of uncoated niob-zirkonium and niob-zirkonium stents coated with iridiumoxide with stainless steel stents was not possible. No new findings for the in-stent-restenosis rate were provided by the results of the control stents. The prototypes of the uncoated niob-zirkonium stents and the niob-zirkonium stents coated with iridiumoxide have to be optimized in their metallurgical characteristics to guarantee an implantation procedure without complications. The alloy niob-zirkonium and the iridiumoxide-coating are excellently biocompatible. Even SUMMARY 117 after a high vascular irritation the stents are embeded into a neointima with only a minimum of cellular response.