Podcasts about apoe

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Tom Dayspring is a world-renowned lipidologist and one of the most thoughtful teachers in the field of lipid metabolism. In this episode, Tom returns to The Drive for a deep dive into the relationship between lipids and brain health, beginning with the fundamentals of cholesterol transport before exploring why the brain's cholesterol system operates almost entirely independently from the rest of the body. Tom examines the roles of apoB, apoA-I, and especially apoE in cholesterol homeostasis, discusses how APOE genotype influences Alzheimer's disease risk, and unpacks the complex links between cholesterol metabolism, amyloid, and tau pathology. He also reviews what is currently known—and still uncertain—about the effects of statins, ezetimibe, omega-3 fatty acids, and emerging CETP inhibitors on brain health and neurodegenerative disease risk. Although highly technical, this conversation provides an essential framework for understanding the nuanced relationship between lipid-lowering therapies, cardiovascular disease prevention, and neurodegenerative diseases in an area often clouded by misinformation. We discuss: The fundamentals of cholesterol transport in the body, and how peripheral cholesterol metabolism differs from cholesterol handling in the brain [2:45]; How cholesterol is transported through plasma and stored within cells, and why lowering LDL cholesterol does not deplete the body or brain of cholesterol [11:45]; How apoB particles drive atherosclerosis, why lowering lipids matters, and the factors that influence individual cardiovascular risk [20:00]; How the brain produces and transports its own cholesterol using apoE lipoproteins independently of circulating cholesterol and apoB-containing lipoproteins [29:00]; How apoB structure influences LDL receptor binding and LDL clearance [39:00]; How neurons acquire cholesterol from apoE-containing lipoproteins and why desmosterol serves as a unique marker of cholesterol synthesis in the brain [41:45]; The difference between the APOE gene and the apoE protein, the major APOE genotypes found in humans, and how APOE4 influences Alzheimer's disease risk [48:45]; HDL function beyond cholesterol: immune function, protein cargo, and communication with the brain [53:30]; How APOE4-associated defects in brain cholesterol transport may promote Alzheimer's disease: amyloid production, neuronal cholesterol homeostasis, and cholesterol clearance [58:00]; Statins and brain health: reviewing the evidence of the potential impact of statins on cognition and Alzheimer's disease risk [1:09:00]; Desmosterol and 24S-hydroxycholesterol as biomarkers of brain cholesterol metabolism and statin effects [1:17:15]; Possible cognitive benefits of ezetimibe beyond lowering apoB [1:19:30]; EPA, DHA, and the evidence for omega-3 fatty acids in brain health [1:23:15]; Obicetrapib: an emerging CETP inhibitor with potential implications for both cardiovascular and brain health [1:31:00]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

Warum werden manche Menschen über 100 Jahre alt – während andere deutlich früher mit altersbedingten Erkrankungen kämpfen? Liegt es am Lebensstil, am Zufall – oder tatsächlich an unseren Genen? In dieser Folge tauchen wir mit Prof. Dr. Joris Deelen vom Leiden University Medical Center tief in die Genetik der Alterung ein und schauen uns zwei der am besten untersuchten Langlebigkeits-Gene genauer an: APOE und FOXO3.

You've seen this before. A genetic report comes back loaded with red SNPs. MTHFR. APOE. COMT, and suddenly everything feels more complicated. More supplements. More restrictions. More second-guessing.That creates overwhelm.In this episode, Dr. Ritamarie breaks down how to actually use genetics in practice without turning it into a list of problems to fix. SNPs aren't diagnoses, and they don't tell you what to do on their own.What matters is how those variants show up in the body.You'll learn how to step back, look at pathways instead of individual SNPs, and connect genetics with labs, symptoms, and physiology, so your decisions actually make sense.If genetic testing has ever made things harder instead of clearer, this will change how you approach it.What's Inside This Episode?• Why genetic testing often creates overwhelm instead of clarity • The problem with focusing on individual SNPs like MTHFR and APOE • Why SNPs are variants, not diagnoses or mutations • The shift from “red flags” to pathway-based thinking • How to integrate genetics with labs, symptoms, and physiology • What to look at instead of reacting to every variant • How to prioritize interventions using systems thinking • Why sequencing matters more than stacking protocolsResources and Links:Download the full transcript hereDownload our FREE Smart Supplementation MatrixJoin the Next-Level Health Practitioner Facebook group here for free resources and community supportVisit INEMethod.com for advanced health practitioner training and tools to elevate your clinical skills and grow your practice by getting life-changing results. Check out our other podcast episodes here

This week on The Life Lab, Brent Franson sits down with Dr. Adam Brickman, a leading expert in brain aging and Alzheimer's research at Columbia University, to unpack what we actually know about measuring brain health. Drawing on nearly three decades of research, Brickman explains the real value and limitations of biomarkers like ApoE genetics, p-tau blood tests, MRIs, and PET scans, and why more information is not always the same as better information. The conversation also explores whether people without symptoms should pursue early testing, the emotional tradeoffs of knowing your risk, and why many of the most effective strategies for protecting the brain remain surprisingly simple. He's a great resource and a wonderful guest. Hope you enjoy.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/NCPD/AAPA information, and to apply for credit, please visit us at PeerView.com/FQM865. CME/NCPD/AAPA credit will be available until April 22, 2027.Strategies for Appropriate Assessment and Use of APOE Status in Alzheimer's Disease: Clinical Care in the Asia-Pacific Region In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Lilly.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/NCPD/AAPA information, and to apply for credit, please visit us at PeerView.com/FQM865. CME/NCPD/AAPA credit will be available until April 22, 2027.Strategies for Appropriate Assessment and Use of APOE Status in Alzheimer's Disease: Clinical Care in the Asia-Pacific Region In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Lilly.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/NCPD/AAPA information, and to apply for credit, please visit us at PeerView.com/FQM865. CME/NCPD/AAPA credit will be available until April 22, 2027.Strategies for Appropriate Assessment and Use of APOE Status in Alzheimer's Disease: Clinical Care in the Asia-Pacific Region In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Lilly.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/NCPD/AAPA information, and to apply for credit, please visit us at PeerView.com/FQM865. CME/NCPD/AAPA credit will be available until April 22, 2027.Strategies for Appropriate Assessment and Use of APOE Status in Alzheimer's Disease: Clinical Care in the Asia-Pacific Region In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Lilly.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/NCPD/AAPA information, and to apply for credit, please visit us at PeerView.com/FQM865. CME/NCPD/AAPA credit will be available until April 22, 2027.Strategies for Appropriate Assessment and Use of APOE Status in Alzheimer's Disease: Clinical Care in the Asia-Pacific Region In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Lilly.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/NCPD/AAPA information, and to apply for credit, please visit us at PeerView.com/FQM865. CME/NCPD/AAPA credit will be available until April 22, 2027.Strategies for Appropriate Assessment and Use of APOE Status in Alzheimer's Disease: Clinical Care in the Asia-Pacific Region In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Lilly.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/NCPD/AAPA information, and to apply for credit, please visit us at PeerView.com/FQM865. CME/NCPD/AAPA credit will be available until April 22, 2027.Strategies for Appropriate Assessment and Use of APOE Status in Alzheimer's Disease: Clinical Care in the Asia-Pacific Region In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Lilly.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/NCPD/AAPA information, and to apply for credit, please visit us at PeerView.com/FQM865. CME/NCPD/AAPA credit will be available until April 22, 2027.Strategies for Appropriate Assessment and Use of APOE Status in Alzheimer's Disease: Clinical Care in the Asia-Pacific Region In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Lilly.Disclosure information is available at the beginning of the video presentation.

In this episode, I sit down with Dr. Daniel Melville to explore how the APOE gene can be used as a powerful tool for personalized health, not just as the so-called Alzheimer's gene. We discuss how genetics can guide nutrition, exercise, and lifestyle choices while blending conventional and integrative medicine for better outcomes. Dr. Melville walks us through his four pillars of wellness, physical, emotional, relational, and spiritual, to help you build a balanced and sustainable approach to long term health.Dr. Daniel Melville is a board certified family medicine physician and founder of Melville Medicine, where he focuses on prevention, integrative care, and personalized health strategies. He has extensive experience in both traditional and emergency medicine, along with advanced training in cardiovascular prevention, cognitive health, and hormone optimization. Through his concierge practice, he partners closely with patients to deliver proactive, individualized care aimed at improving long term health and quality of life.Links mentioned during this episode:Melville Medicine: https://www.melvillemedicine.com/Free Initial Consultation with Dr. Megan: https://p.bttr.to/3a9lfYkLyons' Share Instagram: www.instagram.com/thelyonsshareJoin Megan's newsletter: www.thelyonsshare.org/newsletter

When Penn Holderness described APOE4 as a “ticking time bomb,” it struck a nerve for a lot of people, especially women in midlife who already feel vulnerable about their brain health.Could a GLP-1 medication protect your brain if you carry the APOE4 gene? Amy unpacks the science in plain English and explains why genes are not destiny, why menopause changes the conversation for women, and what research-backed actions you can start taking right now.What to Listen For[00:00] Why Penn Holderness's APOE4 reveal sparked such a big reaction [02:30] What it actually means to carry one or two copies of the APOE4 gene [05:30] Why APOE4 is a genetic predisposition, not a verdict [08:30] The critical difference between APOE4 and the rare genes that directly cause early-onset Alzheimer's [10:30] Why midlife and postmenopausal women may face a different level of APOE4-related risk [14:00] How fear drives people toward quick-fix solutions and why that matters in Alzheimer's prevention [18:00] What the observational GLP-1 research shows and the big caveat most people miss [22:00] What the EVOKE and EVOKE Plus semaglutide trials found in people with early Alzheimer's symptoms [25:30] What hormone therapy can do for sleep and symptom relief — and what it has not been proven to do for dementia prevention [28:30] Why the FINGER study, U.S. POINTER, and modifiable risk-factor research offer the most hopeful path forward [32:30] The free RESTORED guide, the 8 evidence-based lifestyle factors, and Amy's call to take action without panicIf you've been feeling afraid of your genetic risk, this episode is your reminder that APOE4 is not destiny. Amy explains why the most powerful path forward is still grounded in the basics: sleep, movement, metabolic health, stress management, and consistent daily choices. Listen now, subscribe to the show, and grab Amy's free guide so you can start protecting your brain one step at a time.From The EpisodeDownload the free RESTORED ProtocolBook your Breakthrough Roadmap sessionResearch cited in this episode:1. NIA Alzheimer's Disease Genetics Fact Sheet — APOE4 prevalence and risk breakdown https://www.nia.nih.gov/health/alzheimers-causes-and-risk-factors/alzheimers-disease-genetics-fact-sheet2. Altmann A et al. (2014). Sex modifies the APOE-related risk of developing Alzheimer disease. Annals of Neurology. https://pmc.ncbi.nlm.nih.gov/articles/PMC4117990/3. Stanford Medicine (April 2026). Women get Alzheimer's more often than men: Five things the science tells us. https://med.stanford.edu/news/insights/2026/04/women-alzheimers.html4. Alzheimer's Association (2025). Statement on oral semaglutide phase 3 topline data (EVOKE/EVOKE+ trials). https://www.alz.org/news/2025/alzheimers-assRESOURCES:Book a FREE Discovery Call with AmyOrder Amy's book Thoughts Are Habits Too:  Master Your Triggers, Free Yourself From Diet Culture, and Rediscover Joyful Eating.Schedule your Breakthrough Roadmap session with AmyFollow Amy on Instagram @amylangcoaching Follow Amy on Facebook @amylangcoachingSubscribe to Amy's YouTube channel @happyandhealthywithamy

Neuroscientist and frequent STEM-Talk guest Dr. Tommy Wood rejoins us today for part two of our interview about Tommy's book that is fresh off the press and now available in bookstores and Amazon, “The Stimulated Mind: Future-Proof Your Brain from Dementia and Stay Sharp at Any Age.” Tommy is an Associate Professor of Pediatrics and Neuroscience at the University of Washington, where his laboratory focuses on brain health across human lifespan. Tommy is a colleague and good friend who also is a Visiting Research Scientist here at IHMC. In part one of our interview with Tommy, episode 193, we discussed his mission to dispel the myth that the brain is doomed to decline with age. Tommy gave us a fascinating history of neuroscience and how researchers go about studying the brain. Tommy also talked about what is holding us back in terms of addressing an ever-increasing burden of cognitive and mental health disorders that we are experiencing not only here in the U.S., but also around the world. Today, Tommy shares science-backed strategies to help people future-proof their brains. We talk about the importance of diet and exercise in terms of brain health as well as the importance of stimulating and challenging our brains throughout our lifespans. Tommy has a bachelor's degree in biochemistry from the University of Cambridge, a medical degree from the University of Oxford, and a Ph.D. in Physiology and Neuroscience from the University of Oslo. Show notes: [00:03:55 Dawn welcomes Tommy back for part two of his interview by asking him about his recent trip to the UK. [00:04:32] Dawn recaps where we left off with Tommy in part one of our interview, explaining that when we last spoke with Tommy about his book, The Stimulated Mind, we focused on dispelling myths about the adult brain, in particular the idea that the adult brain is fixed. [00:05:22] Ken asks Tommy about advice his father offered when Tommy got accepted into the University of Cambridge. [00:08:03] As a follow-up, Dawn asks if it's fair to say that when Tommy first started working with patients, what he learned in textbooks and classrooms didn't necessarily translate perfectly into the real world and that there is no one-size-fits-all fix. [00:11:54] Ken asks Tommy to expand on what he wrote in his book about the fact that while science can give us a framework for understanding the world, we are always only one experiment or one well-phrased question away from having to completely rethink everything. [00:16:44] Dawn launches into talking about what people can do to future-proof their brain, starting with diet. In the Nourish chapter of his book, Tommy seeks to help people see food as an opportunity for nourishment rather than a source of stress since there are so many conflicting messages about diet and healthy foods out there. Dawn asks Tommy if his opinion is that there is no one-size-fits-all diet? [00:22:21] Dawn explains that what we eat has a direct effect on our long-term health and dementia risk, and within the literature a common theme that emerges regarding eating for brain health is maximizing nutrients. Dawn asks Tommy to talk about what this looks like. [00:24:49] Dawn points out that people today are inundated with advice from health influencers in all directions. She asks Tommy to talk about his advice to tune out the noise and instead of chasing whatever supplement or super food that is currently in vogue, simply to focus on filling your diet with whole, nutrient dense foods. [00:29:43] Ken explains that nutrients are sometimes hard to get in the diet, with somewhere between 15 and 25 percent of people in the U.S. and Europe having inadequate intakes of most B vitamins and even higher deficits in iron, magnesium, calcium, and vitamins C and E, with nutrient deficiencies differing by sex. Women on average are lower in B12, iron, iodine, and calcium, while men are typically lower in magnesium, zinc, and various B vitamins. Ken asks Tommy to give an overview of what these nutrients do in the brain that makes them so critical to cognitive function. [00:35:51] Ken follows up on this discussion by moving on to the section in Tommy's book titled “To Supplement or Not to Supplement” where he discusses the evidence of the benefits of targeted supplementation to fill in the nutrient gaps that exist in the diet. Ken asks Tommy to talk about this more in depth and maybe give a framework by which people can think about adding or not adding key nutrients via supplementation. [00:41:21] Given the controversial reputation red meat has, Ken asks Tommy to weigh in on how he thinks people should think about red meat. [00:46:26] Fish as well, Dawn explains, has become controversial, due to microplastics and mercury concerns. However, given the positive effects on cognitive health that fish consumption has, Dawn asks Tommy to talk about the costs and benefits of increasing fish consumption. [00:50:30] Ken asks about the genetic basis for dementia and in particular Alzheimer's, particularly regarding the APOE genotypes and a recent paper that made the claim that homozygous APOE4/4 carriers were essentially guaranteed to develop ALzherimer's, a strong claim that Ken is skeptical of. [00:57:06] Ken switches gears to talk about brain energy consumption, noting that while the brain is only about 2% of total body mass, it consumes roughly 20% of total energy at rest. Ken mentions that we discussed this topic in episode 59 with Steven Cunnane and asks Tommy to touch on the importance of getting enough energy for the brain and the consequences of not. [01:01:43] Dawn mentions that time restricted eating and fasting have become quite popular in recent years, and is a topic we discussed in episodes 7, and 133 with Mark Mattson. Dawn asks Tommy what some key considerations are for fasting and time restricted eating. [01:04:52] Ken contrasts low energy availability with the prevalent issue in today's modern food environment of high energy availability, leading to epidemics of obesity and type 2 diabetes, both of which are associated with lower brain volume and are both also implicated in projections of higher dementia burdens in the coming decades. Ken asks Tommy to talk about this. [01:08:55] Dawn asks if Tommy has any practical recommendations on how people can assess whether they are fueling the needs of their brain properly. [01:10:38] Ken notes that brain health is tied closely to the extent to which we stimulate our brains, especially as we age, a topic which was discussed at length with Dr. Rudy Tanzi in episode 174. Ken goes on to ask Tommy to talk about the importance of stimulating our brains as we age. [01:13:38] Dawn notes that Tommy made the realization that the brain adapting to stimulus is very similar to how muscles adapt to resistance training after meeting Josh Turknet, a neuroscientist who loves the banjo as much as Tommy loves weight training. Dawn asks Tommy to talk about how his and Josh's respective hobbies have more in common than he originally thought. [01:16:11] Ken asks if this analogy between the brain and muscle extends to ‘muscle memory' or the phenomenon that people who were at one time more muscular are able to gain back that muscle mass more quickly than when they first trained. [01:19:11] Ken mentions that Josh Turknet, the author of the book Anyone Can Play Music, and our guest on episode 130, co-authored a paper with Tommy titled, “Demand coupling drives neurodegeneration, a model of age-related cognitive decline and dementia.” Ken asks Tommy to discuss this paper. [01:22:58] Dawn explains that Tommy writes in his book that exercise science and athletic coaching have given us a really good idea of how a specific stimulus effects performance. But when it comes to this kind of measurement tracking for cognitive function, it's less straightforward. Dawn asks Tommy to talk about this. [01:25:22] Ken mentions that there are lots of ways to stimulate the brain, with some being more potent than others, such as learning a language or an instrument. Ken asks Tommy what some other examples are of good cognitive exercises and learning endeavors that can help develop cognitive headroom as we age. [01:29:14] Ken asks Tommy about the fact that retirement is often the point in someone's life where their cognitive abilities are most at risk, and that delaying retirement, or retiring and choosing to reinvent oneself and engage in a new and challenging adventure can help prevent the cognitive risks associated with retirement. [01:32:32] Dawn notes that exercise is also incredibly important for brain health and asks Tommy to talk about his framework that people can use to think about movement and physical activity as a way to support brain health. [01:37:28] Ken asks Tommy about a study out of Norway that found that people who increased their fitness in their 50s and 60s decreased their subsequent risk of dementia. [01:39:52] Dawn asks Tommy to talk about the growing issue of social media causing people to lose their attention span. [01:44:03] Dawn asks Tommy how he sees AI affecting our brains today. [01:49:17] Ken notes that while most STEM-Talk guests who have written a book say that they would prefer to not repeat the experience, Tommy however, is already thinking about his next book. Ken asks if Tommy can share what this next book will be about. [01:51:26] Dawn asks Tommy about his wife Elizabeth, who was our guest on episode 71, and a researcher at the University of Washington. [01:52:52] Dawn wraps up asking Tommy if, since moving from North Carolina to Washington, if he and Elizabeth have had any luck finding good barbecue in Seattle. Links: Tommy Wood bio STEM-Talk episode 47 with Tommy Wood STEM-Talk episode 110 with Tommy Wood STEM-Talk episode 111 with Tommy Wood STEM-Talk episode 128 with Tommy Wood STEM-Talk episode 193 with Tommy Wood, part 1 Learn more about IHMC STEM-Talk homepage Ken Ford bio Ken Ford Wikipedia page Dawn Kernagis bio  

Early-onset dementia is rising, and the warning signs show up decades before age 65. In this episode, Nurse Doza breaks down 5 dementia warning signs most people overlook — from poor sleep and gut dysfunction to blood sugar, oral health, and omega-3 deficiency — and what you can do right now to protect your brain. FEATURED PRODUCT Brainesium by MSW Nutrition Most magnesium supplements never reach the brain — but magnesium L-threonate does. Brainesium is the only magnesium formula shown to cross the blood-brain barrier, directly supporting synapse function, cognitive health, stress management, and sleep quality. Since sleep disruption and magnesium deficiency are both directly linked to dementia risk, Brainesium is one of the most important steps you can take to protect your brain long-term.

New research reveals that everyday 2.4 GHz Wi-Fi radiation may worsen genetic changes linked to Alzheimer's disease development. Scientists found that prolonged wireless exposure could accelerate neurodegeneration through oxidative stress pathways affecting key genes like GSK3B and APOE. R Blank breaks down this groundbreaking study and explains what it means for the millions of people surrounded by Wi-Fi signals daily. He explores the connection between oxidative stress and brain health, and shares practical steps you can take to reduce your exposure while staying connected. In This Episode How Wi-Fi radiation affects Alzheimer's-related genes The role of oxidative stress in neurodegeneration Why 2.4 GHz frequency exposure is everywhere Simple steps to reduce Wi-Fi exposure at home Featured Study Read the full study: Laván D, Argüelles N, Lluncor A, Huaman D, Moyano J, Ubillus J, Peña M, Paredes M, Hernández I, Guerra A, De La Cruz-Vargas J, Cruz V See all studies at shieldyourbody.com/research

Send us Fan MailIn this episode of Causes or Cures, Dr. Eeks speaks with neurologist and neuroscientist Dr. Majid Fotuhi about brain aging, memory, intelligence, Alzheimer's disease, and his new book: The Invincible Brain: The Clinically-Proven Way to Age-Proof Your Brain and Stay Sharp for LifeWe explore whether Alzheimer's is being overdiagnosed and the idea that what we call Alzheimer's may actually be a mix of different conditions. Dr. Fotuhi breaks down intelligence beyond IQ, including why IQ tests were originally designed to detect deficits, and how environment can shape cognitive potential. We talk about memory, why we forget names but remember certain details, and he shares fun exercises anyone can do to significantly improve their memory.We also examine how technology may be affecting the brain, the concept of use it or lose it, and the role of neuroplasticity in shaping brain function over time.The conversation then turns to prevention. We cover genetics, including the APOE gene, and what you can do to lower your risk, even if you have the high-risk gene. We discuss lifestyle factors such as exercise, sleep, diet, and what having a sense of purpose means for your brain health. We also talk about current treatments, including antibody therapies targeting plaques, and why reducing plaques does not always improve function.Finally, Dr. Fotuhi shares his approach to building brain reserve and maintaining cognitive health through his Brain Fitness Program.Dr. Majid Fotuhi is a neurologist and neuroscientist trained at Johns Hopkins University and Harvard Medical School. He serves as an adjunct professor at the Mind Brain Institute at Johns Hopkins and also teaches at George Washington University and Harvard. With nearly four decades of experience in clinical care, research, and teaching, Dr. Fotuhi has developed a multidisciplinary approach to  improving brain health and cognitive performance. His Brain Fitness Program combines personalized assessment with targeted lifestyle and cognitive interventions, with results published in peer reviewed journals. He is the author of several books, including Boost Your Brain, and is widely recognized for his work on memory, neuroplasticity, and successful aging, with lectures and media appearances around the world.Work with me? Perhaps we are a good match. Keep Causes or Cures Ad-Free with Listener SupportYou can contact Dr. Eeks at bloomingwellness.com.Follow Eeks on Instagram here.Follow Public Health is WeirdOr Facebook here.On Youtube.Or TikTok.SUBSCRIBE to her Newsletter here!Support the showSupport the show

In this episode of Longevity by Design, host Dr. Gil Blander sits down with Dr. Paola Sebastiani, Professor of Biostatistics at Tufts Clinical and Translational Science Institute. They explore what centenarians reveal about reaching 100, and why there's no single longevity gene.Paola explains that studies keep finding many small genetic effects, which makes polygenic risk scores hard to use for personal prediction. She says progress depends on bigger cohorts and new analyses that include structural DNA changes and mitochondrial DNA. She also grounds the hype: for people born in 1900, only 0.2% of men and about 1% of women reached 100.Healthspan sits at the center of the story. Paola ties exceptional aging to delayed disease, lower inflammation, and biomarker profiles that stay more youthful. She highlights diet as a realistic lever, with centenarians showing stable, balanced eating, steadier protein intake, and metabolite signals linked to vegetables and dark chocolate.  Guest-at-a-glance

Today we have Dr. Tommy Wood, a neuroscientist and frequent STEM-Talk guest who joins today on the eve of the publication of his first book, “The Stimulated Mind: Future-Proof Your Brain from Dementia and Stay Sharp at Any Age.” Tommy is an Associate Professor of Pediatrics and Neuroscience at the University of Washington, where his laboratory focuses on brain health across human lifespan. Tommy is a colleague and good friend who also is a Visiting Research Scientist here at IHMC. Today we talk to Tommy about his mission to dispel the myth that the brain is doomed to decline with age. His book, which publishes on March 24 but is available for pre-order on Amazon, offers science-backed strategies to enhance mental sharpness and prevent cognitive decline, including Alzheimer's disease. There was so much to unpack with Tommy about his book, that we decided to split his interview into two parts. Today we talk to Tommy about the history of neuroscience and how researchers go about studying the brain. We also have a conversation with Tommy about what is holding us back in terms of addressing an ever-increasing burden of cognitive and mental health disorders we are experiencing not only here in the U.S., but also around the world. In part two of Tommy' interview, which will air in a few weeks following today's episode, Tommy shares science-backed strategies to help people future-proof their brains. Tommy's lab at the University of Washington focuses on brain health across the lifespan. He conducts research that focuses on ways to treat a range of brain injuries, including babies born preterm and adults who experience brain trauma. He also investigates lifestyle factors that affect long-term cognitive function and increase the risk of dementia. Tommy has a bachelor's degree in biochemistry from the University of Cambridge, a medical degree from the University of Oxford, and a Ph.D. in Physiology and Neuroscience from the University of Oslo. Show notes: [00:04:04] Dawn opens our interview congratulating Tommy on his new book, “The Stimulated Mind.” Dawn asks Tommy what inspired him to write his first book. [00:07:29] Since writing the book consumed more than 18 months of Tommy's life, Dawn asks Tommy if he thinks he'll write another one. [00:09:36] Dawn asks if it's fair to say that the overarching theme of “The Stimulated Mind” is that the conventional belief the adult brain is fixed and incapable of change is wrong. [00:17:35] Ken explains that Tommy opens his book with a story about a study on barn owls, where researchers outfitted a group of owls with prism goggles that altered the perceived position of objects in the owls' vision. While young owls were able to quickly adapt to the change in their vision and return to normal behavior and activities, adult owls, even after months of wearing the goggles, were unable to adapt and would miss mice that were directly under their beaks. However, the research group amended their study design and found something interesting. Ken asks Tommy to explain what they found when they amended their design. [00:22:40] Ken asks Tommy to share how a human study, which outfitted participants with goggles that flipped their vision upside down, demonstrated the adaptability of the adult brain. [00:25:32] Ken asks if these sorts of adaptations have been seen as beyond basic sensory modalities in higher cognitive functions. [00:31:25] Dawn zooms out in our discussion and asks Tommy, given the falsehood of our previous understanding of the adult brain as being fixed, what exactly do we know about the brain. [00:35:36] Dawn asks Tommy to talk about Santiago Ramón y Cajal, who is considered the first neuroscientist. [00:38:41] Dawn mentions chapter two of Tommy's book, “How do Neuroscientists Study the Brain,” in which Tommy explains the complexity of the brain, which is comprised of almost 100 billion neurons which compose nearly a quadrillion synapses. Given the complexity of the brain, Tommy notes in his book that even an organ as complex as the human brain is incapable of fully comprehending its own complexity. Dawn asks Tommy to talk about how he and his colleagues approach studying the brain. [00:43:30] Ken notes the parallels between attempting to understand the function of the brain based on an understanding of its individual components to the process of trying to understand how a piece of software works on a computer by systematically studying the computer's hardware. Ken goes on to start a discussion on the parallels between the brain as a self-referential system that is so complex it cannot even fully understand itself, to various paradoxes as well as Gödel's theorem, while noting that such comparisons are a false equivalency, and the brain is not a formal system in the sense of mathematical proofs. Still, Ken notes, the parallels are interesting. [00:47:07] Dawn asks Tommy about a humorous but insightful section in his book that illustrates the complexity of neurological research called “Can a Biologist Fix a Broken Radio.” Dawn asks Tommy to explain what this analogy is about. [00:52:18] Dawn notes that the modern belief that the adult brain is fixed stems from work done by Cajal in the late 1800s where he claimed that after development the adult brain was no longer capable of regeneration or plasticity. Dawn asks Tommy to touch more on this. [00:56:26] Ken explains that while people are likely familiar with neurons, as the basic building block of the nervous system, most people are less familiar with glial cells, which, until recently, were considered to play a minor role in the brain. However, Tommy in his book, argues that glial cells should be seen as just as important as neurons. Ken notes that within the neuroscience community there is a renewed interest in these cells. [01:02:35] Dawn shifts the conversation to ask about the importance of cardiovascular health in brain health. [01:06:35] Dawn explains that Tommy ends part one of his book by looking at what the brain is actually for, and to answer that question, he first explains that although the brain is capable of adaptation and change over a lifespan, it requires the right environment. To illustrate this, and the fact that dementia is not predetermined, Dawn asks Tommy about the indigenous Tsimané people of the Bolivian Amazon, who have some of the lowest rates of dementia in the world. [01:08:27] Ken asks Tommy if it's true that these people also have a lower prevalence of APOE 4/4 and 3/4 genotypes. [01:11:26] Dawn asks, since one of the aims of Tommy's book is to help people improve their cognitive function and reduce their risk for dementia, if he could give listeners a brief history of Alzheimer's disease. [01:17:07] Ken explains that general warnings that as we get better at treating various diseases and increasing lifespans, we will see an overwhelming number of people develop age-related dementia. Recent studies out of Europe, however, have shown the opposite trend, and that the likelihood of being diagnosed with dementia at the age of 70 is now lower than it was 20 years ago. [01:22:43] Ken and Dawn close out part one of our interview with Tommy by explaining that in part two we will focus our discussion with Tommy on ways people can stimulate neuroplasticity in their adult brains. Ken asks Tommy to close out by briefly discussing the recipe for changing and improving the adult brain. Links: Tommy Wood bio STEM-Talk episode 47 with Tommy Wood STEM-Talk episode 110 with Tommy Wood STEM-Talk episode 111 with Tommy Wood STEM-Talk episode 128 with Tommy Wood Learn more about IHMC STEM-Talk homepage Ken Ford bio Ken Ford Wikipedia page Dawn Kernagis bio  

Welcome to another wide-ranging "Random Show" episode that I recorded with my close friend Kevin Rose (digg.com)!This episode is brought to you by:Eight Sleep Pod Cover 5 sleeping solution for dynamic cooling and heating: EightSleep.com/TimAG1 all-in-one nutritional supplement: DrinkAG1.com/TimCresset family office services for CEOs, founders, and entrepreneurs: CressetCapital.com/TimTimestamps:[00:00:00] A meditative start.[00:02:19] Reflecting on our second Zen retreat in Santa Fe with Henry Shukman.[00:04:08] Ketone liver warnings and eggplant allergies: The perils of raiding Kevin's fridge.[00:08:06] “Just be still” — three simple words that miraculously shut down my OCD.[00:13:54] Is meditation secretly vagus nerve stimulation?[00:20:17] DIY vagus nerve stim for $25 vs. Kevin's $900 ear clip.[00:24:57] HeartMath and watching your HRV move in real time.[00:27:57] Marching toward 50: balance boards and the end of jiu-jitsu.[00:31:26] Tony Hawk snowboarding Hokkaido with screws in his hip.[00:33:01] Slacklining and why your nervous system needs sleep cycles.[00:35:19] Bertolotti's Syndrome: My six-year back pain gets a name.[00:37:09] The nerve block test: everything wrong, zero pain.[00:44:10] Abrahangs tendon protocol: 10 seconds on, 50 off.[00:46:24] The NUG: a pocket hangboard for travelers.[00:48:31] Craig Mod's Japanese toothbrush and Toaster's cameo.[00:50:45] Kevin's $92 vintage fire jacket: Blue Heritage Japan.[00:54:26] Podcast picks: The Power Broker and STEM Talk.[00:56:20] Alzheimer's: A plaque or mitochondrial problem?[00:57:30] 10 grams of ketones turns one-word answers into sentences.[00:58:40] Methylene blue on Amazon: 120 years of research, zero guardrails.[01:02:36] Bredesen Protocol, APOE genotyping, and a cognitive comeback.[01:05:32] Photobiomodulation: $30k laser to the forehead.[01:07:55] Urolithin A and the high price of mitochondrial upkeep.[01:14:56] Recipe for disaster pants: espresso + creatine + MCT oil.[01:17:39] Norwegian 4×4 training and lactate as a brain lever.[01:23:15] Blood flow restriction bands and schwantz ring koans.[01:29:08] Hummingbirds named Sunset and squirrel obstacle courses.[01:32:06] Parting thoughts.*For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim's email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim's books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

В новия епизод на Ratio Weekly Петко и Никола Кереков се гмуркат в науката за деменциите – от най-разпространената форма, болестта на Алцхаймер, до по-рядко обсъждани състояния като съдовата деменция, деменцията с телца на Леви и фронтотемпоралната деменция. Говорят за това какво всъщност се случва в мозъка – от натрупването на неправилно нагънати протеини и загубата на невронни връзки до последиците от инсулти и нарушено кръвоснабдяване. В епизода става дума и за генетичните фактори, включително ролята на гена APOE при риска от Алцхаймер, както и за това защо различните видове деменция често се бъркат една с друга. Разглеждат се и характерните симптоми – от проблеми с паметта и ориентацията до промени в поведението, езика и личността – които показват колко различно може да изглежда когнитивният спад. Представяне на гостите: Д-р Дияна Бележанска е специалист по неврология в Клиниката по неврология към УМБАЛ “Александровска”. Асистент е в Медицинския университет в София. Придобива научна степен “доктор” след защита на дисертационен труд на тема: “Невропсихологични, невроизобразяващи и ликворни биомаркери за болест на Алцхаймер и сродни заболявания”. Основните ѝ интереси са в областта на невродегенеративните заболявания, протичащи с паметови нарушения. Бойко Неов е молекулярен биолог и д-р по паразитология с разнообразни интереси във всички сфери на науката. Към момента той доцент по генетика към Институт по биоразнообразие и Екосистемни изследвания на БАН. Споменато в епизода: https://en.wikipedia.org/wiki/Alzheimer%27s_disease https://en.wikipedia.org/wiki/Vascular_dementia https://en.wikipedia.org/wiki/Lewy_body_dementia https://en.wikipedia.org/wiki/Frontotemporal_dementia https://en.wikipedia.org/wiki/Apolipoprotein_E За подкаста: В епизодите на Ratio Weekly, нашата импровизирана научна новинарска емисия, молекулярният биолог Никола Кереков в компанията на харизматичния водещ Петко Желязов ви представят най-новите открития и най-любопитните постижения в сферата на науката, технологиите и медицината от изминалата седмица. В тази мини-серия на Ratio Podcast говорим за неща като това как да общуваме ефективно с котките, защо китовете се самоубиват и какво живее на Венера.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/EBAC/NCPD/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/VAD865. CME/EBAC/NCPD/AAPA/IPCE credit will be available until 8 March 2027.Strategies for Appropriate Assessment and Use of APOE Status in Alzheimer's Disease: Clinical Care in Europe In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Lilly.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/EBAC/NCPD/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/VAD865. CME/EBAC/NCPD/AAPA/IPCE credit will be available until 8 March 2027.Strategies for Appropriate Assessment and Use of APOE Status in Alzheimer's Disease: Clinical Care in Europe In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Lilly.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/EBAC/NCPD/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/VAD865. CME/EBAC/NCPD/AAPA/IPCE credit will be available until 8 March 2027.Strategies for Appropriate Assessment and Use of APOE Status in Alzheimer's Disease: Clinical Care in Europe In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Lilly.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/EBAC/NCPD/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/VAD865. CME/EBAC/NCPD/AAPA/IPCE credit will be available until 8 March 2027.Strategies for Appropriate Assessment and Use of APOE Status in Alzheimer's Disease: Clinical Care in Europe In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Lilly.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/EBAC/NCPD/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/VAD865. CME/EBAC/NCPD/AAPA/IPCE credit will be available until 8 March 2027.Strategies for Appropriate Assessment and Use of APOE Status in Alzheimer's Disease: Clinical Care in Europe In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Lilly.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/EBAC/NCPD/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/VAD865. CME/EBAC/NCPD/AAPA/IPCE credit will be available until 8 March 2027.Strategies for Appropriate Assessment and Use of APOE Status in Alzheimer's Disease: Clinical Care in Europe In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Lilly.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/EBAC/NCPD/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/VAD865. CME/EBAC/NCPD/AAPA/IPCE credit will be available until 8 March 2027.Strategies for Appropriate Assessment and Use of APOE Status in Alzheimer's Disease: Clinical Care in Europe In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Lilly.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/EBAC/NCPD/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/VAD865. CME/EBAC/NCPD/AAPA/IPCE credit will be available until 8 March 2027.Strategies for Appropriate Assessment and Use of APOE Status in Alzheimer's Disease: Clinical Care in Europe In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Lilly.Disclosure information is available at the beginning of the video presentation.

An estimated 500,000 people are diagnosed with Alzheimer's disease in the United States each year, but the causes and mechanisms of the condition remain a neurological mystery. A recent study looked at the role of variants in a gene called APOE in Alzheimer's, and found that while it's not a simple determinant of developing the disease, that one gene seems to play a significant role in promoting disease risk. Researchers hope work like this could point to new areas to study and even potential treatments. Epidemiologist Dylan Williams joins Host Ira Flatow to explain the findings and discuss the challenges in tracing a complex disease to its roots. Guest: Dr. Dylan Williams is a principal research fellow in molecular and genetic epidemiology at University College London. Transcripts for each episode are available within 1-3 days at sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

In this episode, I sit down with neuroscientist Dr. Louisa Nicola to unpack what women actually need to know about Alzheimer's risk, cognitive decline, and long term brain protection. We break down APOE genetics, advanced blood biomarkers that can now detect amyloid and tau with remarkable accuracy, and why brain health is inseparable from metabolic health. Louisa explains how muscle acts as a metabolic sink for glucose, why resistance training and high intensity intervals stimulate BDNF, and how sleep drives the glymphatic system to clear amyloid from the brain. If you want practical tools to assess your personal risk, understand your labs, and build a proactive prevention plan decades before symptoms appear, this conversation is for you. → Leave Us A Voice Message!  Topics Discussed: → What does APOE4 mean for Alzheimer's risk? → Can exercise prevent cognitive decline? → Do blood tests detect early Alzheimer's? → How does perimenopause affect brain health? → Does hormone therapy reduce dementia risk? Sponsored By:  → Timeline | Support your cells and how you age with Mitopure® Gummies from Timeline. Visit https://timeline.com/KELLY and save up to 39% off your Mitopure® Gummies. → Be Well By Kelly Protein Powder & Essentials | Get $10 off your order with PODCAST10 at https://bewellbykelly.com. → Cozy Earth |  Head to https://cozyearth.com and use code BEWELL for up to 20% off. And if you get a post-purchase survey, make sure you tell them you heard about Cozy Earth right here at the Be Well by Kelly podcast.  → LMNT | Get a free 8-count Sample Pack of LMNT's most popular drink mix flavors with any purchase at https://drinklmnt.com/Kelly. Find your favorite LMNT flavor, or share with a friend. Timestamps:  → 00:00:00 - Introduction → 00:01:27 - Mission to end Alzheimer's  → 00:03:28 - Women's rate of Alzheimer's  → 00:04:11 - Alzheimer's overview  → 00:07:44 - Education level & health  → 00:09:57 - Anatomy  → 00:14:16 - Neuroplasticity & glucose  → 00:19:38 - Amyloid-beta → 00:26:41 - LDL Cholesterol → 00:28:36 - Preparing for menopause  → 00:31:30 - Blood testing recommendations  → 00:34:26 - Lifestyle interventions  → 00:39:05 - Nutrition & the MIND diet  → 00:42:19 - Zone 2 vs zone 5 training  → 00:44:36 - Lactic acid  → 00:47:58 - HRT is protective → 00:50:19 - When to test for HRT → 00:51:56 - Testosterone + brain health  → 00:53:40 - Cognitive reserve  → 00:57:12 - Hot flashes  → 00:58:13 - Quick fixes  → 01:00:01 - Brain surgery  → 01:05:38 - The brain code  Show Links: → Function | Own your health for $365 a year. That's a dollar a day. Learn more and join using my link. Visit https://www.functionhealth.com/bewellbykelly and use gift code BEWELL25 for a $25 credit toward your membership Further Listening: → How to Take Control of Your Health in a Toxic Food Landscape | Max Lugavere  Check Out Louisa:  → Instagram  → The Brain Code Check Out Kelly: → Instagram → Youtube → Facebook

Too busy to read the Lens? Listen to our weekly summary here! In this week's episode we discuss…Associations have been noted between primary open angle/normal tension glaucoma and dementia but do not seem to be correlated with the APOE genotype, the strongest known genetic risk factor for Alzheimer's. Retinal imaging may be an important player in the future diagnosis of bronchopulmonary dysplasia and pulmonary hypertension in neonates.Perimenopause is associated with a clear second peak of uveitis activity after pubertal peak.

La maladie d'Alzheimer touche davantage les femmes que les hommes. Aujourd'hui, près de deux tiers des personnes atteintes sont des femmes. Longtemps, cette différence a été expliquée presque uniquement par un facteur simple : les femmes vivent plus longtemps. Or, les recherches récentes montrent que cette explication est insuffisante. Même à âge égal, les femmes présentent un risque plus élevé de développer la maladie.Une étude de référence publiée dans la revue scientifique Nature Medicine montre que le cerveau féminin vieillit différemment face aux mécanismes d'Alzheimer. Les chercheurs ont mis en évidence des différences biologiques profondes, notamment dans la manière dont les protéines toxiques associées à la maladie s'accumulent et se propagent.Le premier facteur clé est hormonal. Les œstrogènes, hormones sexuelles féminines, jouent un rôle protecteur pour le cerveau. Elles favorisent la plasticité neuronale, soutiennent la mémoire et aident à réguler l'utilisation du glucose par les cellules cérébrales. Or, lors de la ménopause, les niveaux d'œstrogènes chutent brutalement. Cette transition hormonale pourrait rendre le cerveau plus vulnérable aux lésions liées à Alzheimer, en particulier si elle survient précocement ou sans compensation hormonale.Le deuxième facteur est génétique. Le principal gène de risque connu pour Alzheimer, appelé APOE ε4, n'a pas le même impact selon le sexe. Plusieurs études montrent que les femmes porteuses de ce gène présentent un risque plus élevé que les hommes porteurs du même variant. Autrement dit, à patrimoine génétique égal, le cerveau féminin semble plus sensible aux mécanismes pathologiques de la maladie.Troisièmement, le métabolisme cérébral diffère entre les sexes. Les études d'imagerie montrent que, chez les femmes, certaines régions du cerveau impliquées dans la mémoire consomment l'énergie différemment au cours du vieillissement. Cette adaptation, efficace plus jeune, pourrait devenir un point de fragilité avec l'âge.Enfin, des facteurs sociaux entrent aussi en jeu. Les femmes âgées aujourd'hui ont souvent eu, dans leur jeunesse, un accès plus limité à l'éducation ou à des carrières intellectuellement stimulantes. Cela peut réduire la « réserve cognitive », c'est-à-dire la capacité du cerveau à compenser les lésions avant l'apparition des symptômes.En résumé, si les femmes sont plus touchées par Alzheimer, ce n'est pas seulement parce qu'elles vivent plus longtemps. C'est le résultat d'une combinaison de facteurs hormonaux, génétiques, métaboliques et sociaux. Comprendre ces différences est essentiel pour développer, à l'avenir, des stratégies de prévention et de traitement mieux adaptées aux femmes comme aux hommes. Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

In this episode of Health Matters, host Courtney Allison is joined by Dr. Rekha Kumar, endocrinologist and primary care physician at NewYork-Presbyterian and Weill Cornell Medicine, to unpack the science behind aging well. They discuss biohacking, longevity, and health span, separating evidence-based strategies from social media hype and exploring what truly helps us age well.What You'll Learn in This EpisodeWhat “biohacking” really means● How biohacking ranges from simple lifestyle optimization to high-tech, experimental interventions● The difference between lifespan (how long you live) and health span (how long you live well)The Longevity Pyramid● Why the foundation of healthy aging is built on:SleepMovement and strength trainingNutritionStress managementSocial connection● How advanced tools and supplements sit at the top—and why they should never replace the basicsWearables and Tracking● How devices like smartwatches, glucose monitors, and fitness trackers can support behavior change● When tracking becomes counterproductive or stressfulPeptides and “Anti-Aging” Supplements● What's proven (e.g., metformin, GLP-1 receptor agonists)● What's still experimental or under-studied (BPC-157, sermorelin, NAD boosters)Nootropics and Cognitive Enhancers● Everyday nootropics like caffeine● The role of L-theanine for “calm focus”● Myths around perfectly timed caffeine and cortisol rhythmsNutrigenomics and Personalized Nutrition● How genes can influence responses to foods (e.g., lactose intolerance, APOE and saturated fat)● Why many direct-to-consumer genetic tests may overpromiseThe Gut Microbiome● The role of Akkermansia muciniphila in metabolic health● How medications like metformin and GLP-1s may positively shift gut bacteria● What's still unknown about probiotic supplementationGenetic and Biomarker Testing● The difference between actionable medical insights and “information overload”● Why results of unknown significance can cause unnecessary anxietyThe Big Takeaways● There are no true shortcuts to longevity● Sustainable habits beat quick fixes● Our biology is built for rhythms, not constant optimizationFeatured ExpertAbout Rekha B. Kumar, M.D., M.S.Dr. Rekha B. Kumar is an attending endocrinologist at NewYork-Presbyterian/Weill Cornell Medical Center and an associate professor of Clinical Medicine at Weill Cornell Medicine. She specializes in adult primary care and endocrinology and has academic expertise in the diagnosis and treatment of various endocrine disorders, including obesity/weight management, type 2 diabetes, polycystic ovarian syndrome (PCOS), thyroid disorders, as well as metabolic bone disease.Dr. Kumar completed her undergraduate studies at Duke University and received her masters degree in Physiology from Georgetown University. She received her M.D. from New York Medical College and completed her residency training in Internal Medicine at NewYork-Presbyterian/Weill Cornell Medical Center. Dr. Kumar obtained her clinical fellowship in the combined Diabetes, Endocrinology, and Metabolism program at the NewYork-Presbyterian/Weill Cornell Medical Center and the Memorial Sloan Kettering Cancer Center. Dr. Kumar is Board Certified in Internal Medicine, Endocrinology, Diabetes, & Metabolism, and Obesity Medicine.Coming Up NextIn the next episode of Health Matters, we'll explore brain health and the short- and long-term effects of alcohol on the brain with Dr. Hugh Cahill. Subscribe and follow Health Matters on Apple Podcasts, Spotify, or wherever you listen to stay up to date with expert-driven conversations on living well at every stage of life.About Health MattersHealth Matters is your bi-weekly dose of health and wellness information, from the leading experts. Join host Courtney Allison to get news you can use in your own life. New episodes drop each Wednesday.If you are looking for practical health tips and trustworthy information from world-class doctors and medical experts you will enjoy listening to Health Matters. Health Matters was created to share stories of science, care, and wellness that are happening every day at NewYork-Presbyterian, one of the nation's most comprehensive, integrated academic healthcare systems. In keeping with NewYork-Presbyterian's long legacy of medical breakthroughs and innovation, Health Matters features the latest news, insights, and health tips from our trusted experts; inspiring first-hand accounts from patients and caregivers; and updates on the latest research and innovations in patient care, all in collaboration with our renowned medical schools, Columbia and Weill Cornell Medicine.To learn more visit: https://healthmatters.nyp.org

Today on Tech and Science Daily from The Standard, Alan Leer covers a London breakthrough from Moorfields and UCL using a routine eye-surgery gel injection to restore sight in rare hypotony cases, plus new UCL Alzheimer's research on APOE gene risk, Brazil's probe into WhatsApp Business terms, Hytale's early access launch and Minecraft's “cutest drop” tease. Plus a little bit for Genshin fans tooYou'll find all your latest news at Standard.co.uk Hosted on Acast. See acast.com/privacy for more information.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/NCPD/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/JNT865. CME/MOC/NCPD/AAPA/IPCE credit will be available until December 21, 2026.Strategies for Appropriate Assessment and Use of APOE Status in Alzheimer's Disease: Clinical Care in the United States In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Lilly.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/NCPD/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/JNT865. CME/MOC/NCPD/AAPA/IPCE credit will be available until December 21, 2026.Strategies for Appropriate Assessment and Use of APOE Status in Alzheimer's Disease: Clinical Care in the United States In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Lilly.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/NCPD/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/JNT865. CME/MOC/NCPD/AAPA/IPCE credit will be available until December 21, 2026.Strategies for Appropriate Assessment and Use of APOE Status in Alzheimer's Disease: Clinical Care in the United States In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Lilly.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/NCPD/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/JNT865. CME/MOC/NCPD/AAPA/IPCE credit will be available until December 21, 2026.Strategies for Appropriate Assessment and Use of APOE Status in Alzheimer's Disease: Clinical Care in the United States In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Lilly.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/NCPD/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/JNT865. CME/MOC/NCPD/AAPA/IPCE credit will be available until December 21, 2026.Strategies for Appropriate Assessment and Use of APOE Status in Alzheimer's Disease: Clinical Care in the United States In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Lilly.Disclosure information is available at the beginning of the video presentation.

Maximizing your healthspan requires understanding your specific genetic blueprint to see how your body processes fats, carbs, and antioxidants. Standard medical school training provides only a fraction of the education needed to understand nutrition and prevention. I sat down with Dr. Jeff Graham to uncover why common health "hacks" like Vitamin E or intermittent fasting might be backfiring based on your DNA. We explore the transition from high-intensity athletics to longevity-focused movement, and how advanced testing identifies disease risks years before they appear on a standard lab report.Jeff breaks down the impact of the APOE and MTHFR genes on brain health, the surprising anti-inflammatory benefits of sardines, and why muscle mass is your greatest currency as you age. We also discuss the future of AI in diagnostics, the truth about CrossFit injuries, and why contrast therapy is a non-negotiable for cellular resilience."If you're investing in anything with your time or your money that isn't asking you to do something hard most days, then you need to run away." - Dr. Jeff GrahamSupport the show and get 50% off MCT oil with free shipping—just leave us a review on iTunes and let us know!https://podcasts.apple.com/us/podcast/live-beyond-the-norms/id1714886566 About Jeff Graham:Dr. Jeff Graham is a performance and longevity expert combining clinical expertise with precision genomic medicine. He holds a medical degree from the University of Arkansas, completed his residency in North Carolina, and graduated cum laude from a sports medicine fellowship with board certification in lifestyle medicine. As Chief Medical Officer at Wild Health, Jeff focuses on leveraging advanced testing and data-driven insights to maximize health spans for clients ranging from senior executives to competitive CrossFit athletes.Connect with Jeff Graham:- Website: https://wildhealth.com - Instagram: https://www.instagram.com/wildhealthmd/ - LinkedIn: https://www.linkedin.com/in/precisionmdjeff/ Connect with Chris Burres:- Website: https://www.myvitalc.com/ - Website: http://www.livebeyondthenorms.com/ - Instagram: https://www.instagram.com/chrisburres/ - TikTok: https://www.tiktok.com/@myvitalc - LinkedIn: https://www.linkedin.com/in/chrisburres/ DisclaimerThe content shared in this podcast is intended for educational and informational purposes only. It does not constitute medical advice of any kind, nor does it include any specific claims or guarantees. The views expressed are based on personal experiences, research, and individual perspectives, and are meant to inspire and inform listeners on topics related to wellness, lifestyle, and personal development.We strongly encourage all listeners to consult with a qualified professional or licensed expert before making any decisions related to health, finances, or other sensitive areas of life. Thank you for tuning in—and for taking proactive steps toward a more informed, intentional life.

Send us a textDementia is rising, and the toll is personal, social, and economic. From there, we move into a conversation that blends hard data with real life—how hearing loss can quietly erode connection, increase cognitive load, and, according to leading research, contribute to higher dementia risk. Karla Hult joins us with her father's story—an athlete, a community helper, a devoted dad whose final years were shaped by Alzheimer's—and shows how love, grief, and action can coexist without false hope.We break down what the science actually says. The Lancet Commission identifies hearing loss as a leading midlife, modifiable risk factor for dementia. The ACHIEVE study adds nuance: while not all participants saw cognitive gains, a high‑risk subgroup (older adults with cardiovascular risk) experienced significant preservation across cognitive measures when using hearing aids. Everyone, though, benefited socially—less loneliness and richer networks—reminding us that better hearing is not just about volume, it's about vitality. We also demystify genetics and testing: APOE-e4 indicates risk, not destiny, and newer blood tests detect disease only after it starts. That context helps listeners choose action over anxiety.This conversation is practical. We talk about cognitive load at noisy restaurants, the “cocktail party” effect, and how chronic listening strain pushes people to opt out of the moments that keep brains active. We tackle stigma head-on: today's hearing aids are discreet, smart, and designed for real life. For clinicians, we offer a compassionate playbook—lead with connection, avoid cure claims, suggest appropriate cognitive screening, and never leave families without resources. For anyone with family history or early signs of hearing trouble, the message is clear: protect your connections. Get a hearing check, consider amplification when needed, and double down on heart‑brain health habits that keep you engaged with the people and places you love.If this conversation resonates, follow the show, share it with someone who needs it, and leave a review to help others find these insights. Have a topic or guest in mind? Email us at soundbites@starky.com. Connect with the Hearing Matters Podcast TeamEmail: hearingmatterspodcast@gmail.com Instagram: @hearing_matters_podcast Twitter: @hearing_mattasFacebook: Hearing Matters Podcast

Send us a textGenetic & environmental factors that affect brain health, including why people age faster in outer space. (Note: technical difficulties affected the audio quality of this recording somewhat)Episode Summary: Dr. Jacob Raber explains how apolipoproteins, particularly ApoE, influence brain health and disease risk; their role in cholesterol metabolism, Alzheimer's disease, and responses to environmental stressors like radiation and viral infections; interplay between genetics, diet, and lifestyle factors, highlighting how these affect cognitive function and resilience to stress; research into space radiation, the gut-brain axis, and potential interventions for neurodegenerative diseases.About the guest: Jacob Raber, PhD, is a neuroscientist at Oregon Health & Science University (OHSU) in Portland, where he leads a lab studying genetic and environmental influences on brain health, particularly using mouse models with human genes.Discussion Points:Apolipoproteins (ApoE2, E3, E4) are proteins involved in cholesterol and lipid metabolism in the brain, with ApoE4 increasing risks for Alzheimer's and cardiovascular disease.ApoE4 carriers may face higher risks for cognitive decline but could have advantages in specific contexts, like fertility or certain infections.Environmental stressors, such as space radiation and viral infections like West Nile, can exacerbate oxidative stress, impacting brain health.The gut microbiome influences brain function indirectly via the gut-liver-brain axis, with ongoing studies exploring its role in Alzheimer's and traumatic brain injury.Lifestyle factors like diet, exercise, and sleep are critical for brain health, potentially mitigating genetic risks like ApoE4.Statins, commonly used for cholesterol management, may impair learning in healthy animals, suggesting context-dependent effects.Research into space radiation reveals potential therapeutic applications, such as using heavy ion radiation for cancer treatment.Genetic variations, including ethnicity and sex, influence ApoE-related disease risks, with women and certain populations showing higher Alzheimer's susceptibility.Chronic low-level stressors, like air pollution, may pose greater risks to brain health than acute exposures due to insufficient activation of protective mechanisms.Related content:M&M 165: PUFAs in Brain Health & Disease, Dietary Fats, Brain Lipids, Nutrition | Richard Bazinet*Not medical adviceSupport the showAffiliates: Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. For all the ways you can support my efforts

Episode #223 In this Fasting Q&A episode, hosted by Coach Lisa Chance, Dr. Jason Fung answers questions from the TFM Community:   1. I am a healthy 46-year-old working to improve my sleep, so I want to take magnesium bisglycinate. My magnesium supplement actually contains 7 forms of magnesium, which is very convenient, but is it better to just take one form in one capsule for absorption or any other reason? [01:23] 2. Two-part question on TFM's Fat Fasting  One: Vinegar is not on the list, but you have mentioned that we can eat salads. Would it be okay to make a dressing with a healthy oil and vinegar during a Fat Fast?    Two: I've seen some mention to only eat 3-4 of the allowed foods on a fat fast. Is this an alternative manner to step up one's game during a fat fast? [03:58] 3. I just read about a study on stem cell research.  Could you elaborate further what this may mean for those with pancreas, liver, or kidney issues? [08:11] 4. Are there any research-based studies that fasting helps lower cholesterol? [09:55] 5. I'm on day four of a water fast and I am noticing a metallic taste in my mouth. Is this unusual? Why does it happen? [13:46] 6. I have various autoimmune conditions and it was suggested I consider going on LDN (low dose naltrexone), and that this can also help with weight loss. I'm wondering what your thoughts are on LDN for weight loss and, if I decided to start it, how I would incorporate it into my fasting schedule. [16:09] 7. What is the difference between The Dawn Phenomenon and Feet-to-Floor Syndrome? From what I can find they both cause a rise in morning blood sugar, one due to circadian rhythm and the other due to a stress response from getting the day started. Is there a different eating/fasting protocol that is best for one over the other, and how do you know which one you are experiencing? [18:14] 8. Is kidney disease the cause of interstitial cystitis and how do you treat it? [21:05] 9. I have high uric acid and also the APOE 4-4 gene. Would the 3T of lime juice recommended for high uric acid affect the neural autophagy I use as a prevention for the dementia risk? What is the best way to navigate fasting with these two needs? [21:59] 10. Are there any dangers to keeping blood sugars in a consistently low range (50-60's mg/dl) if no symptoms of hypoglycemia are felt? [24:55] 11. In some fasting groups on-line, they are big into breaking fasts with watermelon and fruit juices. How do you feel about breaking fasts with these things? [25:39]   Please note that you need to be a member of the TFM Community to submit questions to the Q&A webinars with Dr. Fung but you can submit questions to our regular Q&A episodes here: https://bit.ly/TFMPodcastQs   Transcripts of all episodes are available on the Podcast page at www.thefastingmethod.com   Explore the TFM Community with a 7-Day FREE TRIAL https://www.thefastingmethod.com/community/   Book a complimentary 15-minute coaching intake assessment with one of the TFM coaches https://www.thefastingmethod.com/coaching/   Connect With Us Instagram: https://www.instagram.com/fastingmethod/ Facebook Page: https://www.facebook.com/TheFastingMethod Join our FREE Facebook Group: https://bit.ly/TFMNetwork   Summary Timestamps 00:00 Intro 01:23 Magnesium 03:58 Vinegar on a fat fast 04:56 Importance of monotony on a fat fast 08:11 Stem cell research 09:55 Fasting and cholesterol  13:46 Metallic taste in mouth on longer fasts 16:09 Low Dose Naltrexone 18:14 Dawn phenomenon vs feet-to-floor syndrome 21:05 Interstitial cystitis 21:59 High uric acid 24:55 Low blood sugar 25:39 Breaking fasts with fruit   Disclaimer This podcast is for educational purposes only and is not a substitute for professional care by a doctor or other qualified medical professional. You should always speak with your physician or other healthcare professional before doing any fasting, changing your diet, taking or adjusting any medication or supplements, or adopting any treatment for a health problem. The use of any other products or services purchased by you as a result of this podcast does not create a healthcare provider-patient relationship between you and any of the experts affiliated with this podcast. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease.

We have the second episode in a series of conversations with Dr. Thomas Dayspring today.  The esteemed Dr. Dayspring is an expert on internal medicine and clinical lipidology. In this episode, we continue with our last conversation, diving into Lp(a) and the influences of gender, race, and menopause. We explain how estrogen is a PCSK9 inhibitor and explore the significance of brain health and risks for dementia. We tackle cholesterol synthesis and discuss the side effects of statins, clarifying who is most susceptible to their impact on the brain. We also examine the significance of the desmosterol biomarker, highlighting the level to aim for, especially when making decisions regarding cholesterol medications, and we answer one question from a listener.  You may want to listen to this insightful conversation with the renowned Dr. Dayspring more than once. He has graciously agreed to return and film additional episodes, where we will dive into more questions from listeners.  IN THIS EPISODE, YOU WILL LEARN: Why Lp(a) is like a wolf in sheep's clothing for many individuals How Lp(a) levels are higher in African Americans and women, especially after menopause  Dr. Dayspring highlights that Lp(a) particles are even more pro-inflammatory than LDL particles How PCSK9 inhibitors are the only drugs that significantly reduce Lp(a) Why do women have a higher risk of dementia than men? Dr. Dayspring explains ApoE as the key lipoprotein for brain cholesterol transport. How statins cross the blood-brain barrier to lower brain cholesterol Why desmosterol levels matter New therapies that can lower ApoB and Lp(a) Why imaging is essential for menopausal women with elevated ApoB and Lp(a) Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Connect with Dr. Thomas Dayspring On X (@Drlipid) On LinkedIn Journal Article: Atherosclerosis: Non-genetic influences on lipoprotein(a) concentrations  Journal of the American Heart Association: Trajectories of Blood Lipid Profiles in Midlife Women: Does Menopause Matter?

Thank you for joining us for our 2nd Cabral HouseCall of the weekend! I'm looking forward to sharing with you some of our community's questions that have come in over the past few weeks…   Tommy: Hello Stephen. I'm an IHP. A year ago I started having dhiarrea daily. My sleep also suffered, waking up in the night unable to fall back asleep even with magnesium/melatonin/breathwork. I had some leftover healthy belly, so began taking 2 morning and 2 night. Everything cleared up, my bowells were perfect , my mind was clearer, my body was calmer. I thought it was the mastic gum that had killed some h-pylori. About 7 days after stopping healthy belly, it all came back again. I've since done a parasite protocol which i had to stop 11 days before the end as I was feeling fatigued. I ran a stool test just before these symptoms and it showed citrabacter friundi. I'm unsure whether to do a parasite protocol again or run another stool test. Appreciate you                                                                                                                                             Tommy: Hello Stephen, I heard you mention that a certain percentage of folk (possibly with the APOE genotype if memory serves me correctly), experience more inflammation with a higher fat diet. Would it be worth running a generic test to refine my unique needs a bit more as I'm prone to inflammation? Obviously this comes after the basic big 5. And Would it also explain susceptibility to mycotoxins? Thankyou for all that you do             Kay: Hi Dr. Cabral, What would you recommend to 59 or 60 year olds who are a pitta/vata body type and tend to be more catabolic when it comes to your DCD? Would you recommend to modify the 2 fasting days? Both my husband and I are generally ok during Day 1 of the fast, but Day 2 is always so difficult - my husband got bad headaches and because he had to work and focus, he ended up prematurely ending the DCD. I have gotten nausea and chills on Day 2, but the most difficult part for me is just really wanting to eat solid food. It also seems that my muscle tone is weakened afterwards. I know that muscle goes away much quicker when you are over the age of 50. Thanks for all your great podcasts- they are always so informative and I look forward to your response!                                 Kay:  Hi Dr. Cabral- Thanks for your awesome podcasts and the opportunity for us to ask you questions. I'm a 59 year old female and am in menopause. I never had cellulite on my arms and back of my upper thighs and glutes until I began taking HRT. Currently, I am on 1mg oral bioidentical estradiol bid and 100 mg oral progesterone qd at bedtime. I also recently began taking 5 mg DHEA (equilife) bid. I am at a good weight (5'2" 110) and do strength training 3 x per week and walk an average of 10k steps per day. I also have recently incorporated your dry brushing techniques and plan to switch to topical HRT sometime this year with the help of my medical provider. I am wondering what else I can do to eliminate the cellulite?                                                                                                                                                                Shelley: Hello, Dr. Cabral! I have recently gone on a health and wellness journey, going from 228 lbs down to now 167 pounds in just over a year. To aid in the process, of course exercise was a part of it. With the exercise came all the injuries of olde, but mainly my knee. I injured it back in my college years playing tennis and surgery wasn't recommended as they wanted to see if it would heal itself (torn meniscus, mostly in the vascular area). Well, fast forward more years than I care to count, and that residual tear on the avascular portion can be problematic. I have been looking into peptides, specifically BPC-157 and TB-500 to potentially help this knee without surgical intervention. What are your thoughts on peptide use (these two in particular) and do you think they might help my knee?           Thank you for tuning into this weekend's Cabral HouseCalls and be sure to check back tomorrow for our Mindset & Motivation Monday show to get your week started off right! - - - Show Notes and Resources: StephenCabral.com/3467 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

Description: In the third and final episode of the healthspan series, Dr. Erin Faules and Dr. Jeff Graham explore the intersection between neurodegenerative disease and metabolic dysfunction—two often-connected drivers of decline. They discuss early detection strategies, the role of genetics, and insulin resistance, and emerging clinical tools to assess and reduce long-term risk. Key Topics Covered: Distinguishing normal aging from neurodegenerative disease Early signs of cognitive decline and how to detect them The role of APOE-4 and other genes in Alzheimer's risk Metabolic dysfunction as a driver of brain aging ("Type 3 diabetes") Blood-based biomarkers: phospho-tau, NFL, CRP, fasting insulin, and more Lifestyle interventions: sleep, strength training, CGMs, circadian-aligned eating Tools like CNS Vital Signs, PET scans, and neuroquant MRIs Supplements and prescriptions: Omega-3s, creatine, berberine, GLP-1s, inositol Connecting muscle mass to glucose control and long-term healthspan

Discover my premium podcast, The Aliquot Vitamin D is far more than just a vitamin—it's a potent steroid hormone regulating nearly 5% of our genome. Yet, remarkably, up to 70% of Americans aren't getting enough, placing them at increased risk for dementia and Alzheimer's disease. In this episode, I explore compelling new evidence from a study involving over 12,000 participants, demonstrating that vitamin D supplementation can reduce dementia risk by an impressive 40%, protecting even adults with genetic Alzheimer's risk (ApoE4 carriers). Timestamps: (00:00) Can vitamin D supplements reduce dementia risk? (00:46) How common is vitamin D deficiency? (03:31) What studies reveal about genes, vitamin D, and dementia (05:44) Does deficiency accelerate brain aging? (06:45) Can vitamin D supplementation enhance cognitive function? (08:15) Dementia risk reduction insights from 12,388 adults (09:58) Why women may benefit most (10:49) Normal vs. impaired cognition—who benefits more from vitamin D? (11:21) Do ApoE4 carriers get dementia protection from vitamin D? (13:00) How mild cognitive impairment affects dementia risk (13:41) Does the form of vitamin D matter? (14:11) What are the optimal vitamin D blood levels? (15:07) What dose corrects deficiency? (15:33) How vitamin D directly supports brain function Watch this episode on YouTube Show notes are available by clicking here The study discussed: Vitamin D supplementation and incident dementia: Effects of sex, APOE, and baseline cognitive status