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An estimated 500,000 people are diagnosed with Alzheimer's disease in the United States each year, but the causes and mechanisms of the condition remain a neurological mystery. A recent study looked at the role of variants in a gene called APOE in Alzheimer's, and found that while it's not a simple determinant of developing the disease, that one gene seems to play a significant role in promoting disease risk. Researchers hope work like this could point to new areas to study and even potential treatments. Epidemiologist Dylan Williams joins Host Ira Flatow to explain the findings and discuss the challenges in tracing a complex disease to its roots. Guest: Dr. Dylan Williams is a principal research fellow in molecular and genetic epidemiology at University College London. Transcripts for each episode are available within 1-3 days at sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.
In this episode, I sit down with neuroscientist Dr. Louisa Nicola to unpack what women actually need to know about Alzheimer's risk, cognitive decline, and long term brain protection. We break down APOE genetics, advanced blood biomarkers that can now detect amyloid and tau with remarkable accuracy, and why brain health is inseparable from metabolic health. Louisa explains how muscle acts as a metabolic sink for glucose, why resistance training and high intensity intervals stimulate BDNF, and how sleep drives the glymphatic system to clear amyloid from the brain. If you want practical tools to assess your personal risk, understand your labs, and build a proactive prevention plan decades before symptoms appear, this conversation is for you. → Leave Us A Voice Message! Topics Discussed: → What does APOE4 mean for Alzheimer's risk? → Can exercise prevent cognitive decline? → Do blood tests detect early Alzheimer's? → How does perimenopause affect brain health? → Does hormone therapy reduce dementia risk? Sponsored By: → Timeline | Support your cells and how you age with Mitopure® Gummies from Timeline. Visit https://timeline.com/KELLY and save up to 39% off your Mitopure® Gummies. → Be Well By Kelly Protein Powder & Essentials | Get $10 off your order with PODCAST10 at https://bewellbykelly.com. → Cozy Earth | Head to https://cozyearth.com and use code BEWELL for up to 20% off. And if you get a post-purchase survey, make sure you tell them you heard about Cozy Earth right here at the Be Well by Kelly podcast. → LMNT | Get a free 8-count Sample Pack of LMNT's most popular drink mix flavors with any purchase at https://drinklmnt.com/Kelly. Find your favorite LMNT flavor, or share with a friend. Timestamps: → 00:00:00 - Introduction → 00:01:27 - Mission to end Alzheimer's → 00:03:28 - Women's rate of Alzheimer's → 00:04:11 - Alzheimer's overview → 00:07:44 - Education level & health → 00:09:57 - Anatomy → 00:14:16 - Neuroplasticity & glucose → 00:19:38 - Amyloid-beta → 00:26:41 - LDL Cholesterol → 00:28:36 - Preparing for menopause → 00:31:30 - Blood testing recommendations → 00:34:26 - Lifestyle interventions → 00:39:05 - Nutrition & the MIND diet → 00:42:19 - Zone 2 vs zone 5 training → 00:44:36 - Lactic acid → 00:47:58 - HRT is protective → 00:50:19 - When to test for HRT → 00:51:56 - Testosterone + brain health → 00:53:40 - Cognitive reserve → 00:57:12 - Hot flashes → 00:58:13 - Quick fixes → 01:00:01 - Brain surgery → 01:05:38 - The brain code Show Links: → Function | Own your health for $365 a year. That's a dollar a day. Learn more and join using my link. Visit https://www.functionhealth.com/bewellbykelly and use gift code BEWELL25 for a $25 credit toward your membership Further Listening: → How to Take Control of Your Health in a Toxic Food Landscape | Max Lugavere Check Out Louisa: → Instagram → The Brain Code Check Out Kelly: → Instagram → Youtube → Facebook
Genetics aren't destiny, they're a roadmap. In this episode, Nikki Burnett explains how epigenetics, detox pathways, blood sugar balance, and daily habits influence your DNA and long-term brain health. You'll learn what longevity really means, how the body repairs damage, and what drives breakdown, from toxins and inflammation to oxidative stress and ultra-processed foods. Nikki also breaks down why nutrients need co-factors, how mitochondria and the microbiome support repair, and what telomeres reveal about biological age. Plus, hear a personal CGM insight that reshaped her view of “healthy” foods and why a precision, personalized approach matters for optimizing cognitive and metabolic health. ⏱️ TIMESTAMPS
Too busy to read the Lens? Listen to our weekly summary here! In this week's episode we discuss…Associations have been noted between primary open angle/normal tension glaucoma and dementia but do not seem to be correlated with the APOE genotype, the strongest known genetic risk factor for Alzheimer's. Retinal imaging may be an important player in the future diagnosis of bronchopulmonary dysplasia and pulmonary hypertension in neonates.Perimenopause is associated with a clear second peak of uveitis activity after pubertal peak.
La maladie d'Alzheimer touche davantage les femmes que les hommes. Aujourd'hui, près de deux tiers des personnes atteintes sont des femmes. Longtemps, cette différence a été expliquée presque uniquement par un facteur simple : les femmes vivent plus longtemps. Or, les recherches récentes montrent que cette explication est insuffisante. Même à âge égal, les femmes présentent un risque plus élevé de développer la maladie.Une étude de référence publiée dans la revue scientifique Nature Medicine montre que le cerveau féminin vieillit différemment face aux mécanismes d'Alzheimer. Les chercheurs ont mis en évidence des différences biologiques profondes, notamment dans la manière dont les protéines toxiques associées à la maladie s'accumulent et se propagent.Le premier facteur clé est hormonal. Les œstrogènes, hormones sexuelles féminines, jouent un rôle protecteur pour le cerveau. Elles favorisent la plasticité neuronale, soutiennent la mémoire et aident à réguler l'utilisation du glucose par les cellules cérébrales. Or, lors de la ménopause, les niveaux d'œstrogènes chutent brutalement. Cette transition hormonale pourrait rendre le cerveau plus vulnérable aux lésions liées à Alzheimer, en particulier si elle survient précocement ou sans compensation hormonale.Le deuxième facteur est génétique. Le principal gène de risque connu pour Alzheimer, appelé APOE ε4, n'a pas le même impact selon le sexe. Plusieurs études montrent que les femmes porteuses de ce gène présentent un risque plus élevé que les hommes porteurs du même variant. Autrement dit, à patrimoine génétique égal, le cerveau féminin semble plus sensible aux mécanismes pathologiques de la maladie.Troisièmement, le métabolisme cérébral diffère entre les sexes. Les études d'imagerie montrent que, chez les femmes, certaines régions du cerveau impliquées dans la mémoire consomment l'énergie différemment au cours du vieillissement. Cette adaptation, efficace plus jeune, pourrait devenir un point de fragilité avec l'âge.Enfin, des facteurs sociaux entrent aussi en jeu. Les femmes âgées aujourd'hui ont souvent eu, dans leur jeunesse, un accès plus limité à l'éducation ou à des carrières intellectuellement stimulantes. Cela peut réduire la « réserve cognitive », c'est-à-dire la capacité du cerveau à compenser les lésions avant l'apparition des symptômes.En résumé, si les femmes sont plus touchées par Alzheimer, ce n'est pas seulement parce qu'elles vivent plus longtemps. C'est le résultat d'une combinaison de facteurs hormonaux, génétiques, métaboliques et sociaux. Comprendre ces différences est essentiel pour développer, à l'avenir, des stratégies de prévention et de traitement mieux adaptées aux femmes comme aux hommes. Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.
In this episode of Health Matters, host Courtney Allison is joined by Dr. Rekha Kumar, endocrinologist and primary care physician at NewYork-Presbyterian and Weill Cornell Medicine, to unpack the science behind aging well. They discuss biohacking, longevity, and health span, separating evidence-based strategies from social media hype and exploring what truly helps us age well.What You'll Learn in This EpisodeWhat “biohacking” really means● How biohacking ranges from simple lifestyle optimization to high-tech, experimental interventions● The difference between lifespan (how long you live) and health span (how long you live well)The Longevity Pyramid● Why the foundation of healthy aging is built on:SleepMovement and strength trainingNutritionStress managementSocial connection● How advanced tools and supplements sit at the top—and why they should never replace the basicsWearables and Tracking● How devices like smartwatches, glucose monitors, and fitness trackers can support behavior change● When tracking becomes counterproductive or stressfulPeptides and “Anti-Aging” Supplements● What's proven (e.g., metformin, GLP-1 receptor agonists)● What's still experimental or under-studied (BPC-157, sermorelin, NAD boosters)Nootropics and Cognitive Enhancers● Everyday nootropics like caffeine● The role of L-theanine for “calm focus”● Myths around perfectly timed caffeine and cortisol rhythmsNutrigenomics and Personalized Nutrition● How genes can influence responses to foods (e.g., lactose intolerance, APOE and saturated fat)● Why many direct-to-consumer genetic tests may overpromiseThe Gut Microbiome● The role of Akkermansia muciniphila in metabolic health● How medications like metformin and GLP-1s may positively shift gut bacteria● What's still unknown about probiotic supplementationGenetic and Biomarker Testing● The difference between actionable medical insights and “information overload”● Why results of unknown significance can cause unnecessary anxietyThe Big Takeaways● There are no true shortcuts to longevity● Sustainable habits beat quick fixes● Our biology is built for rhythms, not constant optimizationFeatured ExpertAbout Rekha B. Kumar, M.D., M.S.Dr. Rekha B. Kumar is an attending endocrinologist at NewYork-Presbyterian/Weill Cornell Medical Center and an associate professor of Clinical Medicine at Weill Cornell Medicine. She specializes in adult primary care and endocrinology and has academic expertise in the diagnosis and treatment of various endocrine disorders, including obesity/weight management, type 2 diabetes, polycystic ovarian syndrome (PCOS), thyroid disorders, as well as metabolic bone disease.Dr. Kumar completed her undergraduate studies at Duke University and received her masters degree in Physiology from Georgetown University. She received her M.D. from New York Medical College and completed her residency training in Internal Medicine at NewYork-Presbyterian/Weill Cornell Medical Center. Dr. Kumar obtained her clinical fellowship in the combined Diabetes, Endocrinology, and Metabolism program at the NewYork-Presbyterian/Weill Cornell Medical Center and the Memorial Sloan Kettering Cancer Center. Dr. Kumar is Board Certified in Internal Medicine, Endocrinology, Diabetes, & Metabolism, and Obesity Medicine.Coming Up NextIn the next episode of Health Matters, we'll explore brain health and the short- and long-term effects of alcohol on the brain with Dr. Hugh Cahill. Subscribe and follow Health Matters on Apple Podcasts, Spotify, or wherever you listen to stay up to date with expert-driven conversations on living well at every stage of life.About Health MattersHealth Matters is your bi-weekly dose of health and wellness information, from the leading experts. Join host Courtney Allison to get news you can use in your own life. New episodes drop each Wednesday.If you are looking for practical health tips and trustworthy information from world-class doctors and medical experts you will enjoy listening to Health Matters. Health Matters was created to share stories of science, care, and wellness that are happening every day at NewYork-Presbyterian, one of the nation's most comprehensive, integrated academic healthcare systems. In keeping with NewYork-Presbyterian's long legacy of medical breakthroughs and innovation, Health Matters features the latest news, insights, and health tips from our trusted experts; inspiring first-hand accounts from patients and caregivers; and updates on the latest research and innovations in patient care, all in collaboration with our renowned medical schools, Columbia and Weill Cornell Medicine.To learn more visit: https://healthmatters.nyp.org
Today on Tech and Science Daily from The Standard, Alan Leer covers a London breakthrough from Moorfields and UCL using a routine eye-surgery gel injection to restore sight in rare hypotony cases, plus new UCL Alzheimer's research on APOE gene risk, Brazil's probe into WhatsApp Business terms, Hytale's early access launch and Minecraft's “cutest drop” tease. Plus a little bit for Genshin fans tooYou'll find all your latest news at Standard.co.uk Hosted on Acast. See acast.com/privacy for more information.
Your genes aren't your destiny. In this episode, Nikki Burnett explores how your genetic blueprint influences metabolism, inflammation, detox, and nutrient needs—and why personalized nutrition matters. You'll learn why cookie-cutter diets often fail, how genetics and epigenetics shape your response to food, and what key SNPs like APOE, MTHFR, FADS2, TCF7L2, and PPAR-alpha reveal about fat metabolism, carbs, methylation, and keto response. Nikki also connects ancestry, environment, and lifestyle to gene expression, showing how to layer genetics with labs and symptoms for real-world results. The takeaway is simple: you're not failing your diet—your diet may be failing you. Understanding your DNA helps you stop guessing and start supporting your body the way it actually needs. ⏱️ KEY MOMENTS
This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/NCPD/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/JNT865. CME/MOC/NCPD/AAPA/IPCE credit will be available until December 21, 2026.Strategies for Appropriate Assessment and Use of APOE Status in Alzheimer's Disease: Clinical Care in the United States In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Lilly.Disclosure information is available at the beginning of the video presentation.
PeerView Neuroscience & Psychiatry CME/CNE/CPE Audio Podcast
This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/NCPD/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/JNT865. CME/MOC/NCPD/AAPA/IPCE credit will be available until December 21, 2026.Strategies for Appropriate Assessment and Use of APOE Status in Alzheimer's Disease: Clinical Care in the United States In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Lilly.Disclosure information is available at the beginning of the video presentation.
This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/NCPD/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/JNT865. CME/MOC/NCPD/AAPA/IPCE credit will be available until December 21, 2026.Strategies for Appropriate Assessment and Use of APOE Status in Alzheimer's Disease: Clinical Care in the United States In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Lilly.Disclosure information is available at the beginning of the video presentation.
PeerView Neuroscience & Psychiatry CME/CNE/CPE Video Podcast
This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/NCPD/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/JNT865. CME/MOC/NCPD/AAPA/IPCE credit will be available until December 21, 2026.Strategies for Appropriate Assessment and Use of APOE Status in Alzheimer's Disease: Clinical Care in the United States In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Lilly.Disclosure information is available at the beginning of the video presentation.
This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/NCPD/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/JNT865. CME/MOC/NCPD/AAPA/IPCE credit will be available until December 21, 2026.Strategies for Appropriate Assessment and Use of APOE Status in Alzheimer's Disease: Clinical Care in the United States In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Lilly.Disclosure information is available at the beginning of the video presentation.
This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/NCPD/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/JNT865. CME/MOC/NCPD/AAPA/IPCE credit will be available until December 21, 2026.Strategies for Appropriate Assessment and Use of APOE Status in Alzheimer's Disease: Clinical Care in the United States In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Lilly.Disclosure information is available at the beginning of the video presentation.
Maximizing your healthspan requires understanding your specific genetic blueprint to see how your body processes fats, carbs, and antioxidants. Standard medical school training provides only a fraction of the education needed to understand nutrition and prevention. I sat down with Dr. Jeff Graham to uncover why common health "hacks" like Vitamin E or intermittent fasting might be backfiring based on your DNA. We explore the transition from high-intensity athletics to longevity-focused movement, and how advanced testing identifies disease risks years before they appear on a standard lab report.Jeff breaks down the impact of the APOE and MTHFR genes on brain health, the surprising anti-inflammatory benefits of sardines, and why muscle mass is your greatest currency as you age. We also discuss the future of AI in diagnostics, the truth about CrossFit injuries, and why contrast therapy is a non-negotiable for cellular resilience."If you're investing in anything with your time or your money that isn't asking you to do something hard most days, then you need to run away." - Dr. Jeff GrahamSupport the show and get 50% off MCT oil with free shipping—just leave us a review on iTunes and let us know!https://podcasts.apple.com/us/podcast/live-beyond-the-norms/id1714886566 About Jeff Graham:Dr. Jeff Graham is a performance and longevity expert combining clinical expertise with precision genomic medicine. He holds a medical degree from the University of Arkansas, completed his residency in North Carolina, and graduated cum laude from a sports medicine fellowship with board certification in lifestyle medicine. As Chief Medical Officer at Wild Health, Jeff focuses on leveraging advanced testing and data-driven insights to maximize health spans for clients ranging from senior executives to competitive CrossFit athletes.Connect with Jeff Graham:- Website: https://wildhealth.com - Instagram: https://www.instagram.com/wildhealthmd/ - LinkedIn: https://www.linkedin.com/in/precisionmdjeff/ Connect with Chris Burres:- Website: https://www.myvitalc.com/ - Website: http://www.livebeyondthenorms.com/ - Instagram: https://www.instagram.com/chrisburres/ - TikTok: https://www.tiktok.com/@myvitalc - LinkedIn: https://www.linkedin.com/in/chrisburres/ DisclaimerThe content shared in this podcast is intended for educational and informational purposes only. It does not constitute medical advice of any kind, nor does it include any specific claims or guarantees. The views expressed are based on personal experiences, research, and individual perspectives, and are meant to inspire and inform listeners on topics related to wellness, lifestyle, and personal development.We strongly encourage all listeners to consult with a qualified professional or licensed expert before making any decisions related to health, finances, or other sensitive areas of life. Thank you for tuning in—and for taking proactive steps toward a more informed, intentional life.
Send us a textDementia is rising, and the toll is personal, social, and economic. From there, we move into a conversation that blends hard data with real life—how hearing loss can quietly erode connection, increase cognitive load, and, according to leading research, contribute to higher dementia risk. Karla Hult joins us with her father's story—an athlete, a community helper, a devoted dad whose final years were shaped by Alzheimer's—and shows how love, grief, and action can coexist without false hope.We break down what the science actually says. The Lancet Commission identifies hearing loss as a leading midlife, modifiable risk factor for dementia. The ACHIEVE study adds nuance: while not all participants saw cognitive gains, a high‑risk subgroup (older adults with cardiovascular risk) experienced significant preservation across cognitive measures when using hearing aids. Everyone, though, benefited socially—less loneliness and richer networks—reminding us that better hearing is not just about volume, it's about vitality. We also demystify genetics and testing: APOE-e4 indicates risk, not destiny, and newer blood tests detect disease only after it starts. That context helps listeners choose action over anxiety.This conversation is practical. We talk about cognitive load at noisy restaurants, the “cocktail party” effect, and how chronic listening strain pushes people to opt out of the moments that keep brains active. We tackle stigma head-on: today's hearing aids are discreet, smart, and designed for real life. For clinicians, we offer a compassionate playbook—lead with connection, avoid cure claims, suggest appropriate cognitive screening, and never leave families without resources. For anyone with family history or early signs of hearing trouble, the message is clear: protect your connections. Get a hearing check, consider amplification when needed, and double down on heart‑brain health habits that keep you engaged with the people and places you love.If this conversation resonates, follow the show, share it with someone who needs it, and leave a review to help others find these insights. Have a topic or guest in mind? Email us at soundbites@starky.com. Connect with the Hearing Matters Podcast TeamEmail: hearingmatterspodcast@gmail.com Instagram: @hearing_matters_podcast Twitter: @hearing_mattasFacebook: Hearing Matters Podcast
Send us a textGenetic & environmental factors that affect brain health, including why people age faster in outer space. (Note: technical difficulties affected the audio quality of this recording somewhat)Episode Summary: Dr. Jacob Raber explains how apolipoproteins, particularly ApoE, influence brain health and disease risk; their role in cholesterol metabolism, Alzheimer's disease, and responses to environmental stressors like radiation and viral infections; interplay between genetics, diet, and lifestyle factors, highlighting how these affect cognitive function and resilience to stress; research into space radiation, the gut-brain axis, and potential interventions for neurodegenerative diseases.About the guest: Jacob Raber, PhD, is a neuroscientist at Oregon Health & Science University (OHSU) in Portland, where he leads a lab studying genetic and environmental influences on brain health, particularly using mouse models with human genes.Discussion Points:Apolipoproteins (ApoE2, E3, E4) are proteins involved in cholesterol and lipid metabolism in the brain, with ApoE4 increasing risks for Alzheimer's and cardiovascular disease.ApoE4 carriers may face higher risks for cognitive decline but could have advantages in specific contexts, like fertility or certain infections.Environmental stressors, such as space radiation and viral infections like West Nile, can exacerbate oxidative stress, impacting brain health.The gut microbiome influences brain function indirectly via the gut-liver-brain axis, with ongoing studies exploring its role in Alzheimer's and traumatic brain injury.Lifestyle factors like diet, exercise, and sleep are critical for brain health, potentially mitigating genetic risks like ApoE4.Statins, commonly used for cholesterol management, may impair learning in healthy animals, suggesting context-dependent effects.Research into space radiation reveals potential therapeutic applications, such as using heavy ion radiation for cancer treatment.Genetic variations, including ethnicity and sex, influence ApoE-related disease risks, with women and certain populations showing higher Alzheimer's susceptibility.Chronic low-level stressors, like air pollution, may pose greater risks to brain health than acute exposures due to insufficient activation of protective mechanisms.Related content:M&M 165: PUFAs in Brain Health & Disease, Dietary Fats, Brain Lipids, Nutrition | Richard Bazinet*Not medical adviceSupport the showAffiliates: Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. For all the ways you can support my efforts
In this interview, Andrea Donsky, nutritionist, menopause educator, and published menopause researcher and co-founder of WeAreMorphus.com, discusses how hormonal birth control can mask where you are in the menopausal transition, what labs help, and how to talk to your doctor about safer options. Elizabeth Katzman specializes in Functional Diagnostic Nutrition for women in perimenopause and menopause. She'll help you connect the dots if you've taken the pill in the past or are on the pill now. Topic Covered: What the pill does (synthetic estrogen + progestin), why the “period” on it is a withdrawal bleed, and how it can hide your true perimenopause status.Why progestins can raise anxiety/depression risk, and how bioidentical progesterone supports sleep, mood, bones, and thyroid.Thyroid connection: How the pill can deplete nutrients and interfere with T4→T3 conversion, and raise hypothyroid risk when midlife thyroid issues already spike.Leaky gut, depleted lacto/bifido, and why protecting your mucosal lining matters for autoimmune risk.Testing that helps (and when): Why FSH/E2/Progesterone timing matters off the pill, plus affordable bloodwork that gives clues even when hormones fluctuate.How to think about nutrient repletion (methylated B's, magnesium, zinc, selenium) and why an IUD or mini-pill (progestin-only) isn't automatically a better choice.Topical/oral/vaginal progesterone options, DHEA and pregnenolone basics, and why “fit + formulation + timing” often matter more than the dose.Red meat, ferritin, and genetics: Why iron can climb post-menopause, when to watch ferritin, and how genetics (MTHFR, APOE) affect it.When your long-time GYN isn't the right HRT partner, and how to add a practitioner who actually understands midlife hormones.Links From The Show:Perimenopause, Menopause & Pelvic Health SurveyDNA CompanyWhy You Should Test Your Iron Levels in Menopause with Dr. Christy SuttonDr. Thomas Perls on Longevity Tips from Studying CentenariansUnderstanding Bio-Send us a text ✅ Fill out our surveys: https://bit.ly/4jcVuLh
Episode #223 In this Fasting Q&A episode, hosted by Coach Lisa Chance, Dr. Jason Fung answers questions from the TFM Community: 1. I am a healthy 46-year-old working to improve my sleep, so I want to take magnesium bisglycinate. My magnesium supplement actually contains 7 forms of magnesium, which is very convenient, but is it better to just take one form in one capsule for absorption or any other reason? [01:23] 2. Two-part question on TFM's Fat Fasting One: Vinegar is not on the list, but you have mentioned that we can eat salads. Would it be okay to make a dressing with a healthy oil and vinegar during a Fat Fast? Two: I've seen some mention to only eat 3-4 of the allowed foods on a fat fast. Is this an alternative manner to step up one's game during a fat fast? [03:58] 3. I just read about a study on stem cell research. Could you elaborate further what this may mean for those with pancreas, liver, or kidney issues? [08:11] 4. Are there any research-based studies that fasting helps lower cholesterol? [09:55] 5. I'm on day four of a water fast and I am noticing a metallic taste in my mouth. Is this unusual? Why does it happen? [13:46] 6. I have various autoimmune conditions and it was suggested I consider going on LDN (low dose naltrexone), and that this can also help with weight loss. I'm wondering what your thoughts are on LDN for weight loss and, if I decided to start it, how I would incorporate it into my fasting schedule. [16:09] 7. What is the difference between The Dawn Phenomenon and Feet-to-Floor Syndrome? From what I can find they both cause a rise in morning blood sugar, one due to circadian rhythm and the other due to a stress response from getting the day started. Is there a different eating/fasting protocol that is best for one over the other, and how do you know which one you are experiencing? [18:14] 8. Is kidney disease the cause of interstitial cystitis and how do you treat it? [21:05] 9. I have high uric acid and also the APOE 4-4 gene. Would the 3T of lime juice recommended for high uric acid affect the neural autophagy I use as a prevention for the dementia risk? What is the best way to navigate fasting with these two needs? [21:59] 10. Are there any dangers to keeping blood sugars in a consistently low range (50-60's mg/dl) if no symptoms of hypoglycemia are felt? [24:55] 11. In some fasting groups on-line, they are big into breaking fasts with watermelon and fruit juices. How do you feel about breaking fasts with these things? [25:39] Please note that you need to be a member of the TFM Community to submit questions to the Q&A webinars with Dr. Fung but you can submit questions to our regular Q&A episodes here: https://bit.ly/TFMPodcastQs Transcripts of all episodes are available on the Podcast page at www.thefastingmethod.com Explore the TFM Community with a 7-Day FREE TRIAL https://www.thefastingmethod.com/community/ Book a complimentary 15-minute coaching intake assessment with one of the TFM coaches https://www.thefastingmethod.com/coaching/ Connect With Us Instagram: https://www.instagram.com/fastingmethod/ Facebook Page: https://www.facebook.com/TheFastingMethod Join our FREE Facebook Group: https://bit.ly/TFMNetwork Summary Timestamps 00:00 Intro 01:23 Magnesium 03:58 Vinegar on a fat fast 04:56 Importance of monotony on a fat fast 08:11 Stem cell research 09:55 Fasting and cholesterol 13:46 Metallic taste in mouth on longer fasts 16:09 Low Dose Naltrexone 18:14 Dawn phenomenon vs feet-to-floor syndrome 21:05 Interstitial cystitis 21:59 High uric acid 24:55 Low blood sugar 25:39 Breaking fasts with fruit Disclaimer This podcast is for educational purposes only and is not a substitute for professional care by a doctor or other qualified medical professional. You should always speak with your physician or other healthcare professional before doing any fasting, changing your diet, taking or adjusting any medication or supplements, or adopting any treatment for a health problem. The use of any other products or services purchased by you as a result of this podcast does not create a healthcare provider-patient relationship between you and any of the experts affiliated with this podcast. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease.
Listen to 128 Future Now Show- Memory Helpers What is the color of your brain, any idea? According to Bobby Wilder, our science correspondent, orange and blue brains are a sign of good health, thanks to the abundant use of brain supplements that enhance cognition. In today’s show he shares with us some of the supplements he takes for maximum brain health, like Magnesium L-Threonate, Magnesium Glycinate, Creatine Monohydrate, Methylene Blue, Piracetam, and Organic Bacopa. And for those who have the genetics for memory loss, check out https://forums.apoe4.info/. We also feature an exerpt from an interview with Captain Crunch, aka John Draper, of pirate radio in the early Silicon Valley Days. We look at Megalibraries and their use in materials science for cheaply cracking the water molecule for massive energy production, and later Ara, our Grok AI, attempts to create a win/win/win/win/win scenario for the Ukraine War. All in an afternoon’s podcast..Enjoy! Bobby Wilder on “what’s good for the brain is good for the body’
We are discussing perspective changes in neurology genetics with the crossover of the APOE gene in neuro and cardio as well as telehealth for neurology predictive testing. Segment 1: Is it time for a paradigm shift? Inclusion of APOE on genetic dyslipidemia panels. Emily Brown is a certified genetic counselor at the Center for Inherited Heart Disease at Johns Hopkins Hospital. She graduated from the University of Maryland Genetic Counseling Program in 2014 and has practiced in cardiology for the past 10 years. Her main areas of interest include dyslipidemias, and she is a member of the National Lipid Association. Hannah Ison is a cardiovascular genetic counselor at the Stanford Center for Inherited Cardiovascular Disease. She received her Master's in Medical and Molecular Genetics from Indiana University in 2018, and returned home to California to begin her career. Her primary clinical interest includes working with patients who have inherited lipid conditions in both the adult and pediatric setting. A large part of her role has been focused on developing a Pediatric Lipid Clinic at the Stanford Children's Hospital, allowing her to care for patients across the generations. Hannah was the co-chair of the Dyslipidemia Working Group through the cardiovascular SIG from 2020-2024 where she worked with members to develop dyslipidemia resources. In addition to her work in the lipid space, she also provides inpatient and outpatient genetic counseling to patients with isolated congenital heart disease, and enjoys participating in various research opportunities. In this segment we discuss: - APOE's relevance in both Alzheimer's and cardiovascular disease - Counseling strategies for APOE alleles (ε2, ε3, and ε4), including penetrance, lifestyle modification, and exploration of risk for conditions and symptoms external to Alzheimer's - Case studies highlighting APOE's diagnostic, variant, and treatment insights - The need for standardization, education, and reframing of APOE testing in practice Segment 2: Patient-reported outcomes for remote and in-person visits for genetic counseling in adult neurology. Rachel A. Paul, MS, CGC and Laynie Dratch, ScM, CGC are board-certified genetic counselors who specialize in adult neurogenetics and work with the Penn Neurogenetics Therapy Center team in Philadelphia, PA (https://www.linkedin.com/company/penn-neurogenetics-therapy-center). Rachel provides clinical and research genetic counseling services for the Division of Movement Disorders at the University of Pennsylvania. Her research interests include genetic screening for clinical trials access, remote/telemedicine genetic services, and motivations/barriers for genetics utilization. She graduated cum laude from Temple University in Philadelphia, previously worked as a genetic counseling assistant (GCA) for the Penn neurogenetics program, and completed her training with the Arcadia University (now University of Pennsylvania) Genetic Counseling Program. Laynie's clinical focus includes frontotemporal degeneration (FTD) spectrum disorders, amyotrophic lateral sclerosis (ALS), and other neurodegenerative conditions. Her research interests include the lived experiences of at-risk individuals, predictive genetic testing considerations, and genetic counseling access and service delivery. She graduated summa cum laude from Colgate University with a BA in neuroscience and a minor in psychology, and completed her genetic counseling masters training at the Johns Hopkins University and the National Institutes of Health. In this segment we discuss: - How COVID-19 pushed neurogenetics counseling from in-person to telehealth. - Why patient satisfaction stayed high across both formats, with video outperforming phone. - What drives visit preferences—travel, tech comfort, privacy, and clinical needs. - Future research to refine protocols, improve access, and explore broader applications. Would you like to nominate a JoGC article to be featured in the show? If so, please fill out this nomination submission form here. Multiple entries are encouraged including articles where you, your colleagues, or your friends are authors. Stay tuned for the next new episode of DNA Dialogues! In the meantime, listen to all our episodes Apple Podcasts, Spotify, streaming on the website, or any other podcast player by searching, “DNA Dialogues”. For more information about this episode visit dnadialogues.podbean.com, where you can also stream all episodes of the show. Check out the Journal of Genetic Counseling here for articles featured in this episode and others. Any questions, episode ideas, guest pitches, or comments can be sent into DNADialoguesPodcast@gmail.com. DNA Dialogues' team includes Jehannine Austin, Naomi Wagner, Khalida Liaquat, Kate Wilson and DNA Today's Kira Dineen. Our logo was designed by Ashlyn Enokian. Our current intern is Stephanie Schofield.
We have the second episode in a series of conversations with Dr. Thomas Dayspring today. The esteemed Dr. Dayspring is an expert on internal medicine and clinical lipidology. In this episode, we continue with our last conversation, diving into Lp(a) and the influences of gender, race, and menopause. We explain how estrogen is a PCSK9 inhibitor and explore the significance of brain health and risks for dementia. We tackle cholesterol synthesis and discuss the side effects of statins, clarifying who is most susceptible to their impact on the brain. We also examine the significance of the desmosterol biomarker, highlighting the level to aim for, especially when making decisions regarding cholesterol medications, and we answer one question from a listener. You may want to listen to this insightful conversation with the renowned Dr. Dayspring more than once. He has graciously agreed to return and film additional episodes, where we will dive into more questions from listeners. IN THIS EPISODE, YOU WILL LEARN: Why Lp(a) is like a wolf in sheep's clothing for many individuals How Lp(a) levels are higher in African Americans and women, especially after menopause Dr. Dayspring highlights that Lp(a) particles are even more pro-inflammatory than LDL particles How PCSK9 inhibitors are the only drugs that significantly reduce Lp(a) Why do women have a higher risk of dementia than men? Dr. Dayspring explains ApoE as the key lipoprotein for brain cholesterol transport. How statins cross the blood-brain barrier to lower brain cholesterol Why desmosterol levels matter New therapies that can lower ApoB and Lp(a) Why imaging is essential for menopausal women with elevated ApoB and Lp(a) Connect with Cynthia Thurlow Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Connect with Dr. Thomas Dayspring On X (@Drlipid) On LinkedIn Journal Article: Atherosclerosis: Non-genetic influences on lipoprotein(a) concentrations Journal of the American Heart Association: Trajectories of Blood Lipid Profiles in Midlife Women: Does Menopause Matter?
Using biomarker testing and APOE genotyping to determine patient eligibility for amyloid-targeting therapies. Credit available for this activity expires: 8/19/2026 Earn Credit / Learning Objectives & Disclosures: https://www.medscape.org/viewarticle/1002844?ecd=bdc_podcast_libsyn_mscpedu
In part two of this two-part series, Dr. Stacey Clardy and Casey R. Vanderlip discuss the changes that neurologists should implement in their clinics based on the findings from this study regarding APOE genotype. Show reference: https://www.neurology.org/doi/10.1212/WNL.0000000000213853
In part one of this two part series, Dr. Stacey Clardy and Casey R. Vanderlip discuss what neurologists need to know about how APOE4 and amyloid interact to impact cognitive function. Show reference: https://www.neurology.org/doi/10.1212/WNL.0000000000213853
Dr. Stacey Clardy talks with Casey R. Vanderlip about whether the accelerated decline in episodic memory among APOE4 carriers is due to increased Aβ deposition or heightened susceptibility to Aβ-related effects. Read the related article in Neurology®. Disclosures can be found at Neurology.org.
What if your doctor was the one who needed saving?In this eye-opening episode of The Big Silence, Karena Dawn sits down with Dr. Darshan Shah, a surgeon, longevity expert, and founder of Next Health. After decades in medicine and a career spent helping others, Dr. Shah found himself battling chronic disease, obesity, depression, and burnout. But it wasn't pills or procedures that saved him. It was a radical shift toward root-cause healing and functional medicine. This episode dives deep into the science behind metabolic health, food and mood, hormones, inflammation, and even Alzheimer's prevention. If you've ever felt like your health was spiraling or your mind was foggy beyond repair, this conversation is your invitation to start again from a smarter, stronger, and more self-aware place.What's the Real Cause of Chronic Illness, and Can We Reverse It Without Medication?Dr. Shah explains why most health advice treats symptoms, not causes, and how root-cause medicine, nutrition, and tracking your biomarkers can change everything.(00:03:15) When the Doctor Becomes the Patient: Dr. Shah's Wake-Up CallAt 42, Dr. Shah was 50 pounds overweight, had high blood pressure, prediabetes, and depression — despite being a leading surgeon.He realized that traditional medicine taught him how to treat disease, but not how to prevent or reverse it.His journey into functional medicine began with uncovering the root causes of mental and physical illness.The experience made him rethink everything he thought he knew about health — and launched his mission to transform care from reactive to proactive.(00:11:05) Food, Mood & Metabolic Disease: What Your Grocery Cart Isn't Telling YouUltra-processed foods cause nutrient deficiencies, inflammation, and metabolic chaos — and often trigger depression and anxiety.Reducing sugar and refined carbs (like bread, pasta, and pastries) is critical to brain and body health.Dr. Shah recommends key books:Good Energy by Dr. Casey MeansBrain Energy by Dr. Christopher PalmerGlucose Revolution by Jessie InchauspéMetabolic health is deeply connected to mental health — you can't treat one without addressing the other.(00:14:19) Hormones, Bloodwork & Becoming the Boss of Your Own BiologyMost doctors don't check thyroid, testosterone, or estrogen levels — even though these regulate nearly every cell in your body.Annual (or even quarterly) bloodwork is essential to catch changes before they become diagnoses.At home, you can track body composition with a bioimpedance scale and sleep/stress with wearables.Knowing your health data empowers you to take action before symptoms spiral.(00:18:44) Fitness for Longevity: Why “Exercise Snacks” Work Better Than the GymDr. Shah encourages 3–5 minute movement breaks throughout the day — called “exercise snacks” — to counteract sedentary behavior.Research shows that every 45 minutes of sitting increases your risk of disease. Breaking it up adds up fast.Karena shares how she intuitively built strength this way with small workout breaks.Your genome is malleable, based 95% on your day-to-day habits and 5 % genetics.(00:24:22) Alzheimer's, Genes & How to Take Control of Your Brain's FutureHaving the APOE gene doesn't guarantee Alzheimer's, but lifestyle factors like poor sleep, sugar consuption, and inflammation increase risk.Dr. Shah outlines 15 modifiable root causes of cognitive decline, from toxins to sedentary behavior.Healing your gut, balancing blood sugar, and protecting your mitochondria can dramatically reduce your...
In this video, Dr. Doug Lucas explores the multifaceted role of vitamin K2 in health, particularly its impact on bone strength and heart health. He delves into the complexities of vitamin K2, including its genetic implications, the differences between MK4 and MK7 forms, and the importance of personalized dosing. The discussion also highlights the APOE gene's influence on vitamin K metabolism and the need for a comprehensive approach to bone health, emphasizing the balance of fat-soluble vitamins and the potential long-term effects of high-dose supplementation.Interested in learning your APOE Genotype? US Viewers can order the Apolipoprotein E Genotype test through my RUPA labs store: https://labs.rupahealth.com/store/storefront_eGJqjM4Dr. Doug Show YouTube Viewers can receive exclusive savings on AlgaeCal products with this link: https://algaecalinc.pxf.io/c/3093029/2859752/27609*STUDIES*https://www.mdpi.com/2072-6643/16/15/2420
Thank you for joining us for our 2nd Cabral HouseCall of the weekend! I'm looking forward to sharing with you some of our community's questions that have come in over the past few weeks… Tommy: Hello Stephen. I'm an IHP. A year ago I started having dhiarrea daily. My sleep also suffered, waking up in the night unable to fall back asleep even with magnesium/melatonin/breathwork. I had some leftover healthy belly, so began taking 2 morning and 2 night. Everything cleared up, my bowells were perfect , my mind was clearer, my body was calmer. I thought it was the mastic gum that had killed some h-pylori. About 7 days after stopping healthy belly, it all came back again. I've since done a parasite protocol which i had to stop 11 days before the end as I was feeling fatigued. I ran a stool test just before these symptoms and it showed citrabacter friundi. I'm unsure whether to do a parasite protocol again or run another stool test. Appreciate you Tommy: Hello Stephen, I heard you mention that a certain percentage of folk (possibly with the APOE genotype if memory serves me correctly), experience more inflammation with a higher fat diet. Would it be worth running a generic test to refine my unique needs a bit more as I'm prone to inflammation? Obviously this comes after the basic big 5. And Would it also explain susceptibility to mycotoxins? Thankyou for all that you do Kay: Hi Dr. Cabral, What would you recommend to 59 or 60 year olds who are a pitta/vata body type and tend to be more catabolic when it comes to your DCD? Would you recommend to modify the 2 fasting days? Both my husband and I are generally ok during Day 1 of the fast, but Day 2 is always so difficult - my husband got bad headaches and because he had to work and focus, he ended up prematurely ending the DCD. I have gotten nausea and chills on Day 2, but the most difficult part for me is just really wanting to eat solid food. It also seems that my muscle tone is weakened afterwards. I know that muscle goes away much quicker when you are over the age of 50. Thanks for all your great podcasts- they are always so informative and I look forward to your response! Kay: Hi Dr. Cabral- Thanks for your awesome podcasts and the opportunity for us to ask you questions. I'm a 59 year old female and am in menopause. I never had cellulite on my arms and back of my upper thighs and glutes until I began taking HRT. Currently, I am on 1mg oral bioidentical estradiol bid and 100 mg oral progesterone qd at bedtime. I also recently began taking 5 mg DHEA (equilife) bid. I am at a good weight (5'2" 110) and do strength training 3 x per week and walk an average of 10k steps per day. I also have recently incorporated your dry brushing techniques and plan to switch to topical HRT sometime this year with the help of my medical provider. I am wondering what else I can do to eliminate the cellulite? Shelley: Hello, Dr. Cabral! I have recently gone on a health and wellness journey, going from 228 lbs down to now 167 pounds in just over a year. To aid in the process, of course exercise was a part of it. With the exercise came all the injuries of olde, but mainly my knee. I injured it back in my college years playing tennis and surgery wasn't recommended as they wanted to see if it would heal itself (torn meniscus, mostly in the vascular area). Well, fast forward more years than I care to count, and that residual tear on the avascular portion can be problematic. I have been looking into peptides, specifically BPC-157 and TB-500 to potentially help this knee without surgical intervention. What are your thoughts on peptide use (these two in particular) and do you think they might help my knee? Thank you for tuning into this weekend's Cabral HouseCalls and be sure to check back tomorrow for our Mindset & Motivation Monday show to get your week started off right! - - - Show Notes and Resources: StephenCabral.com/3467 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!
Description: In the third and final episode of the healthspan series, Dr. Erin Faules and Dr. Jeff Graham explore the intersection between neurodegenerative disease and metabolic dysfunction—two often-connected drivers of decline. They discuss early detection strategies, the role of genetics, and insulin resistance, and emerging clinical tools to assess and reduce long-term risk. Key Topics Covered: Distinguishing normal aging from neurodegenerative disease Early signs of cognitive decline and how to detect them The role of APOE-4 and other genes in Alzheimer's risk Metabolic dysfunction as a driver of brain aging ("Type 3 diabetes") Blood-based biomarkers: phospho-tau, NFL, CRP, fasting insulin, and more Lifestyle interventions: sleep, strength training, CGMs, circadian-aligned eating Tools like CNS Vital Signs, PET scans, and neuroquant MRIs Supplements and prescriptions: Omega-3s, creatine, berberine, GLP-1s, inositol Connecting muscle mass to glucose control and long-term healthspan
Discover all of the podcasts in our network, search for specific episodes, get the Optimal Living Daily workbook, and learn more at: OLDPodcast.com. Episode 3043: Many traditional diets share key traits like rich sources of fat-soluble vitamins and the absence of processed foods, but Ben Greenfield highlights why your ideal diet depends heavily on your unique genetics. From amylase production to ApoE variants and vitamin A conversion, this piece reveals how ancestral eating patterns and individual gene expression shape the best nutritional approach for your body. Read along with the original article(s) here: https://bengreenfieldlife.com/article/nutrition-articles/how-to-figure-out-what-diet-is-right-for-you/ Quotes to ponder: "The more AMY1 copies you've inherited (and the more of this enzyme you produce as a result), the better your starch-metabolizing capabilities will be." "Depending on what you inherited from your parents, you'll carry a combination of any two ApoE variants: ApoE2, ApoE3, or ApoE4." "Two common mutations on the BCM01 gene, which helps govern the beta-carotene-to-vitamin-A conversion process, make it nearly impossible to get enough vitamin A from the plant kingdom alone." Learn more about your ad choices. Visit megaphone.fm/adchoices
Discover all of the podcasts in our network, search for specific episodes, get the Optimal Living Daily workbook, and learn more at: OLDPodcast.com. Episode 3043: Many traditional diets share key traits like rich sources of fat-soluble vitamins and the absence of processed foods, but Ben Greenfield highlights why your ideal diet depends heavily on your unique genetics. From amylase production to ApoE variants and vitamin A conversion, this piece reveals how ancestral eating patterns and individual gene expression shape the best nutritional approach for your body. Read along with the original article(s) here: https://bengreenfieldlife.com/article/nutrition-articles/how-to-figure-out-what-diet-is-right-for-you/ Quotes to ponder: "The more AMY1 copies you've inherited (and the more of this enzyme you produce as a result), the better your starch-metabolizing capabilities will be." "Depending on what you inherited from your parents, you'll carry a combination of any two ApoE variants: ApoE2, ApoE3, or ApoE4." "Two common mutations on the BCM01 gene, which helps govern the beta-carotene-to-vitamin-A conversion process, make it nearly impossible to get enough vitamin A from the plant kingdom alone." Learn more about your ad choices. Visit megaphone.fm/adchoices
For many women, memory changes during perimenopause and menopause can be unsettling. We find ourselves wondering: Is this just brain fog? Is this normal? Or could it be something more serious? In this critical episode, Shelley Craft is joined by Professor Ralph Martins, AO, one of the world's leading Alzheimer's researchers, to help us separate fact from fear and to understand what's really going on in our brains as we age. Dementia is now the leading cause of death for women in Australia, yet so few are talking about it. This conversation is about breaking the silence, reducing fear, and creating a proactive plan to protect our brain health — starting today. Here's a snapshot of our conversation:
Discover my premium podcast, The Aliquot Vitamin D is far more than just a vitamin—it's a potent steroid hormone regulating nearly 5% of our genome. Yet, remarkably, up to 70% of Americans aren't getting enough, placing them at increased risk for dementia and Alzheimer's disease. In this episode, I explore compelling new evidence from a study involving over 12,000 participants, demonstrating that vitamin D supplementation can reduce dementia risk by an impressive 40%, protecting even adults with genetic Alzheimer's risk (ApoE4 carriers). Timestamps: (00:00) Can vitamin D supplements reduce dementia risk? (00:46) How common is vitamin D deficiency? (03:31) What studies reveal about genes, vitamin D, and dementia (05:44) Does deficiency accelerate brain aging? (06:45) Can vitamin D supplementation enhance cognitive function? (08:15) Dementia risk reduction insights from 12,388 adults (09:58) Why women may benefit most (10:49) Normal vs. impaired cognition—who benefits more from vitamin D? (11:21) Do ApoE4 carriers get dementia protection from vitamin D? (13:00) How mild cognitive impairment affects dementia risk (13:41) Does the form of vitamin D matter? (14:11) What are the optimal vitamin D blood levels? (15:07) What dose corrects deficiency? (15:33) How vitamin D directly supports brain function Watch this episode on YouTube Show notes are available by clicking here The study discussed: Vitamin D supplementation and incident dementia: Effects of sex, APOE, and baseline cognitive status
How important is one's family history when determining Alzheimer's risk? Returning guests Drs. Jessica Langbaum and Sterling Johnson discuss the latest research on family history and genetic risk factors and share their perspectives on the topic, specifically focusing on the role of the APOE gene as a risk factor. Guests: Sterling Johnson, PhD, leader, Wisconsin Registry for Alzheimer's Prevention (WRAP), associate director, Wisconsin Alzheimer's Disease Research Center, associate director, Wisconsin Alzheimer's Institute, lead principal investigator, ADRC Consortium for Clarity in ADRD Research Through Imaging (CLARiTI), Jean R. Finley Professor of Geriatrics and Dementia, UW School of Medicine and Public Health, and Jessica Langbaum, PhD, senior director of research strategy, Banner Alzheimer's Institute, overseer, Observational Research Program, Clinical Trials Program, Alzheimer's Prevention Initiative, director, Alzheimer's Prevention Registry, director, Arizona Alzheimer's Disease Research Center Show Notes Read Dr. Langbaum's viewpoint, “The Risk of Alzheimer Disease in APOE4 Homozygotes,” on the Journal of American Medical Association (JAMA) website. Read Dr. Johnson's article, “APOE4 homozygosity represents a distinct genetic form of Alzheimer's disease,” on Nature Medicine's website. Read Dr. Chin's opinion piece, “What to do if your family has a history of Alzheimer's,” mentioned at 2:04 on the Wisconsin State Journal's website. Please note there is a paywall to access the article. Read Dr. Tobey Betthauser's paper, “Multi-method investigation of factors influencing amyloid onset and impairment in three cohorts,” mentioned by Dr. Johnson at 16:50, on the National Library of Medicine's website. Learn more about the Banner Alzheimer's Institute on their website. Read about the GeneMatch program from the Alzheimer's Prevention Registry on their website. Learn more about the Arizona Alzheimer's Disease Research Center on their website. Connect with us Find transcripts and more at our website. Email Dementia Matters: dementiamatters@medicine.wisc.edu Follow us on Facebook and Twitter. Subscribe to the Wisconsin Alzheimer's Disease Research Center's e-newsletter. Enjoy Dementia Matters? Consider making a gift to the Dementia Matters fund through the UW Initiative to End Alzheimer's. All donations go toward outreach and production.
In this episode of Research Renaissance, host Deborah Westphal sits down with Dr. Alberto Serrano-Pozo, Assistant Professor of Neurology at Harvard Medical School, staff neurologist at Massachusetts General Hospital, and a 2022 Toffler Scholar. Together, they explore Dr. Serrano-Pozo's pioneering research into the role of glial cells—specifically astrocytes—and the APOE gene in the development and progression of Alzheimer's disease.Dr. Serrano-Pozo discusses how astrocytes, long overlooked in favor of neurons, are now recognized as key players in maintaining brain health—and how their dysfunction may contribute to Alzheimer's pathology. The conversation also covers the complexities of the APOE gene variants, how recent discoveries are reshaping our understanding of Alzheimer's across different populations, and promising advances in gene-editing research.Dr. Serrano-Pozo also reflects on the dual role he plays as both a researcher and a clinician, how patient interactions inspire his lab work, and why cautious optimism is warranted as new therapies and technologies emerge.What You'll Learn:Why astrocytes are crucial to brain function—and how they change in Alzheimer'sThe evolving understanding of the APOE gene's role in Alzheimer's riskHow glial cells interact with amyloid plaques and tau tanglesWhy certain APOE variants affect populations differentlyAdvances in gene-editing that may offer future protection against Alzheimer'sThe real-world challenges and rewards of balancing clinical practice with researchA hopeful look at the accelerating pace of Alzheimer's research and innovationKey Quotes:
Could the signs of Alzheimer's and dementia appear before middle age? Join host Chuck Carroll and renowned expert Dr. Neal Barnard on The Exam Room Podcast as they explore new research revealing that symptoms of cognitive decline may begin as early as your 30s or 40s. Discover the early warning signs, what causes them, and what you can do today to protect your brain health. Subscribe for more expert interviews on health, nutrition, and disease prevention. - In This Interview - - What age dementia signs can first appear - The cause of cognitive deficits at a young age - The APOE ε4 factor - Hippocampus and memory loss - Best foods for fighting dementia - And more — — SHOW LINKS — — Dementia Study https://bit.ly/AlzYouthStudy — — — Gregory J. Reiter Memorial Fund https://gregoryreiterfund.org — — — Chuck on The Fit Vegan Podcast YouTube: https://www.youtube.com/watch?v=xHoTC5gpQ8c Apple: https://podcasts.apple.com/us/podcast/the-untold-side-of-chuck-carrolls-265-lbs-weight/id1540427138?i=1000705562110 Spotify: https://open.spotify.com/episode/4FkGmNEEnDHT0dVUUueH1a?si=5461a466976d4e25 — — EVENTS — — Exam Room LIVE: Longevity and Muscle Building GreenFare Organic Restaurant Where: Herndon, VA When: May 28, 2025 Tix: https://bit.ly/ERTixGFMay2025 — — — NHA Conference Where: Cleveland, OH When: June 26-29, 2025 Tix & Speakers: https://www.healthscience.org/2025-nha-conference — — — International Conference on Nutrition in Medicine Where: Washington, DC When: August 14-16, 2025 Tix & Speakers: https://www.pcrm.org/icnm — — BECOME AN EXAM ROOM VIP — — Sign up: https://www.pcrm.org/examroomvip — — THIS IS US — — The Exam Room Podcast Instagram: https://www.instagram.com/theexamroompodcast — — — Chuck Carroll Instagram: https://www.instagram.com/ChuckCarrollWLC Facebook: https://www.facebook.com/ChuckCarrollWLC X: https://www.twitter.com/ChuckCarrollWLC — — — Physicians Committee Instagram: https://www.instagram.com/physicianscommittee Facebook: https://www.facebook.com/PCRM.org X: https://www.twitter.com/pcrm YouTube: https://www.youtube.com/user/PCRM Jobs: https://www.pcrm.org/careers — — SUBSCRIBE & SHARE — — 5-Star Success: Share Your Story Apple: https://apple.co/2JXBkpy Spotify: https://spoti.fi/2pMLoY3 Please subscribe and give the show a 5-star rating on Apple Podcasts, Spotify, or many other podcast providers. Don't forget to share it with a friend for inspiration!
Do our cholesterol numbers tell the full story? Cardiometabolic health encompasses more than just heart function—it includes metabolic processes, blood sugar control, lipid levels, and inflammation markers that affect your entire body's health. Fewer than 12% of Americans are metabolically healthy, making it crucial to look beyond standard cholesterol numbers to understand your complete cardiovascular risk profile.In today's episode, functional nutritionist Chris Newport explores hidden factors that could be quietly impacting your heart and metabolic health.You'll discover: • Why traditional cholesterol tests might miss critical warning signs • What the size of your LDL particles can reveal about your risk • The simple blood test that offers a clearer picture of heart disease risk • A genetic marker that could influence your heart health—whether your labs are "normal" or not • How your body's ability to shift between fuel sources impacts your long-term health • The surprising link between blood sugar, carbs, and cholesterol problems • A fresh look at heart health through the American Heart Association's updated roadmap • How your environment and lifestyle could silently shape your risk • Why tiny daily habits can lead to massive improvements over time
In this episode, we sit down with Dr. Matthew Dawson, the founder and CEO of Wild Health, and leader in genomics-based precision medicine. Dr. Matt breaks down what precision medicine truly means--how it goes beyond traditional healthcare to create highly personalized plans based on your unique genetic blueprint and blood work. We explore some of the most important genes to assess for optimizing health, performance, and longevity, including the ApoE gene. He shares powerful insights into the future of medicine and why understanding your genetics is crucial for extending healthspan. Plus, we open up about our own personal Wild Health test results and how they've shaped our individual wellness journey. This conversation is packed with actionable insights you won't want to miss!Dr. Matthew Dawson is the founder and CEO of Wild Health, a genomics-based precision medicine company, and the CEO of TruDiagnostic, an epigenetics testing lab. He has authored two textbooks, published over two dozen studies, lectured in over 20 countries, and won national awards for education and innovation. His passion is unlocking the secrets of the genome and epigenome and using them to optimize health and maximize healthspan. He lives in the woods with his wife, four children, and two dogs.SHOW NOTES: 0:31 Welcome to the show!3:57 Dr. Matt Dawson's Bio4:40 Welcome Dr. Matt to the show!5:14 What is “Precision Medicine”?7:14 Your genes are not your destiny11:09 Renee's experience with Bulletproof coffee11:38 MTHFR & Homocysteine12:43 Combining lab work with genetics17:24 Alzheimer's genetics20:32 What to do for APOE-3/422:56 Biomarkers for optimal health 24:28 Can you change your sleep chronotype?28:26 Genes for telomere length31:37 *ALIGN MAT*33:16 *PIQUE TEA*35:27 Boosting BDNF37:30 Something new about HbA1C!39:47 FOXO3 Gene for Longevity43:40 Blue Zones & social connection45:12 Testing Biological Age49:08 Caloric Restriction for Longevity51:42 The perfect diet for your genes53:25 Comparing macro tolerances57:37 Wild Health reports 59:12 Coming soon for Precision Medicine!1:04:16 His final piece of advice1:04:56 Thanks for tuning in!RESOURCES:Website: wildhealth.com - discount code: BIOHACKERBABESInstagram: wildhealthmdLinkedIn: Wild HealthMy Align Mat - discount code: BIOHACKERBABES to save $250Pique Tea - Save $ with this link!Puori - Save 20% with discount code: BIOHACKERBABESEffecty - Save $50 with discount code: BIOHACKERBABESOur Sponsors:* Check out Effecty and use my code BIOHACKERBABES for a great deal: https://www.effecty.com* Check out Puori: https://Puori.com/BIOHACKERBABESSupport this podcast at — https://redcircle.com/biohacker-babes-podcast/donationsAdvertising Inquiries: https://redcircle.com/brands
In this episode, I sat down with Dr. Heather Sandison to talk about something that needs more attention Alzheimer's disease, and whether it can actually be reversed. She challenges the conventional belief that it's irreversible and dives into how environmental toxins, poor lifestyle habits, and hidden infections can drive cognitive decline. We broke it all down using the acronym "TNSSS-I" — Toxins, Nutrients, Stressors, Structure, Signaling, and Infections. Dr. Sandison shares powerful recommendations: an organic ketogenic diet, dual-task exercises, proper sleep, and detoxing from things like heavy metals, mold, and chemicals. We also touched on gut health, oral hygiene, blood sugar balance, and the role of APOE gene testing. If you've been impacted by Alzheimer's or want to protect your brain for the long run this episode gives you the practical tools and real hope. #alzheimer #wellness #antiaging Dr. Heather Sandison IG: @dr.heathersandison ==== Thank You To Our Sponsors! Calroy Head on over to at calroy.com/drg and Save over $50 when you purchase the Vascanox and Arterosil bundle at https://calroy.com/rachel. Cornbread Hemp Head to cornbreadhemp.com/DRG and use code DRG at checkout for a special discount—Cornbread Hemp: This is the good life. ==== Be sure to like and subscribe to #HealThySelf Hosted by Doctor Christian Gonzalez N.D. Follow Doctor G on Instagram @doctor.gonzalez https://www.instagram.com/doctor.gonzalez/ Sign up for our newsletter! https://drchristiangonzalez.com/newsletter/
Two-thirds of those diagnosed with Alzheimer's disease are women — but why? In this episode, we unpack the neurological, hormonal, and social drivers that uniquely affect women's brain health during the menopausal transition — from estrogen's protective role in the brain to the misunderstood history of hormone replacement therapy. We discuss: • Why women face a higher risk of Alzheimer's than men • How menopause accelerates brain aging (and how it starts earlier than is often expected) • The role of estrogen in brain metabolism and neuroprotection • The real story behind hormone replacement therapy (HRT) • The impact of genes like APOE4 on women's brain health • How lifestyle factors like stress, sleep, and cognitive activity can help reduce the impact of neurological changes onset by menopause ——— Get our free curation of women's brain health resources in our Brain Box: http://thebraindocs.com/brainbox ——— To help us tell this story, we welcome three world-renowned women's health experts to the podcast: DR. LISA MOSCONI: Director of the Women's Brain Initiative, author of ‘The Menopause Brain', and pioneering researcher in brain imaging and hormonal neuroscience. MARIA SHRIVER: Founder of the Women's Alzheimer's Movement, journalist, and relentless advocate for gender equity in brain health research. DR. LISA GENOVA: Neuroscientist and bestselling author of ‘Still Alice', which was adapted into a film starring Julianne Moore, who won the 2015 Best Actress Oscar for her role as Alice Howland. This is... Your Brain On Menopause. ‘Your Brain On' is hosted by neurologists, scientists and public health advocates Ayesha and Dean Sherzai. ‘Your Brain On... Menopause' • SEASON 5 • EPISODE 1 ——— Our free Women's Brain Health Brain Box includes: • Guides on how to speak with healthcare providers about menopause • Delicious brain-healthy Mother's Day brunch recipes • Meaningful gift ideas for the women you love • Inspiring interviews with world-leading women's health experts • And even a chance to check your cognitive health with an insightful, science-backed test Get the Brain Box for free! Here: http://thebraindocs.com/brainbox ——— References: Mosconi, L. (2017). Perimenopause and emergence of an Alzheimer's bioenergetic phenotype in brain and periphery. PloS One, 12(10), e0185926. Belloy, M. E. & Alzheimer's Disease Neuroimaging Initiative. (2019). A quarter century of APOE and Alzheimer's disease: Progress to date and the path forward. Neuron, 101(5), 820-838. Rahman, A. (2019). Sex and gender driven modifiers of Alzheimer's: The role for estrogenic control across age, race, medical, and lifestyle risks. Frontiers in Aging Neuroscience, 11, 315. Rocca, W. A. (2012). Hysterectomy, oophorectomy, estrogen, and the risk of dementia. Neurodegenerative Diseases, 10(1-4), 175-178. Scheyer, O. (2018). Female sex and Alzheimer's risk: The menopause connection. Journal of Prevention of Alzheimer's Disease, 5(4), 225-230. Women's Health Initiative Memory Study Investigators. (2003). Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: The Women's Health Initiative Memory Study—a randomized controlled trial. JAMA, 289(20), 2651–2662. Women's Health Initiative Investigators. (2002). Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the Women's Health Initiative randomized controlled trial. JAMA, 288(3), 321-333. Whitmer, R. A. (2005). Midlife cardiovascular risk factors and risk of dementia in late life. Neurology, 64(2), 277-281. Livingston, G. (2024). Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission. The Lancet, 404(10452), 572-628. Maki, P. M. (2016). Hormone therapy, dementia, and cognition: The Women's Health Initiative 10 years on. Climacteric, 19(3), 313-315.
In this week's episode we'll learn more about how phosphoseryl-tRNA kinase inhibition promotes cell death in acute myeloid leukemia, or AML; APOE gene variants and their association with post-hematopoietic stem cell transplant outcomes in AML; and pathways by which chronic inflammation and oxidative stress may lead to cardiomyopathy in patients with sickle cell disease.Featured Articles:PSTK inhibition activates cGAS-STING, precipitating ferroptotic cell death in leukemic stem cells Common Hereditary Variants of the APOE Gene and Posttransplant Outcome in Acute Myeloid Leukemia 17R-Resolvin D1 Protects Against Sickle Cell Related Inflammatory Cardiomyopathy in Humanized Mice
In this episode, I'm joined by Dr. Dale Bredesen, a true pioneer in Alzheimer's research and functional medicine. Together, we dive into groundbreaking advancements in the world of neurodegenerative diseases, with a special focus on the exciting breakthroughs in detecting and potentially reversing Alzheimer's and other related conditions. Dr. Bredesen sheds light on the new disease mechanisms and innovative blood tests that are changing the game, showing us that cognitive decline isn't something we simply have to accept. We also explore his integrative approach to combating Alzheimer's, which includes lifestyle modifications, early detection, and a holistic strategy for better brain health. This conversation is packed with hope and real strategies for a future where Alzheimer's doesn't have to be inevitable. Key Takeaways: New Era of Research: Alzheimer's and similar neurodegenerative diseases are not death sentences, thanks to innovative research and new treatment protocols that emphasize early detection and intervention. Significance of Gut Health: Investigations reveal that gut microbiota and inflammation are crucial risk factors in cognitive decline, underscoring the importance of gut health in preventing Alzheimer's. Role of Lifestyle Changes: Diet, exercise, sleep, and stress management are integral to maintaining brain health and can significantly influence the progression of neurodegenerative diseases. Advance in Diagnostics: Cutting-edge blood tests such as P Tau217 and brain scans can detect early signs of Alzheimer's up to 20 years prior to diagnosis, offering opportunities for preemptive action. The Power of Personalized Medicine: Individualized protocols based on genetic testing, like assessing APOE status, are pivotal in developing effective prevention and treatment strategies for cognitive disorders. More About Dr. Dale Bredesen: Dr. Dale Bredesen, M.D., is a globally recognized expert in neurodegenerative diseases, particularly Alzheimer's disease. With a background that includes graduating from Caltech and earning his M.D. from Duke University Medical Center, Dr. Bredesen's career is marked by groundbreaking research and clinical expertise. He completed his residency as chief resident in neurology at UCSF and further honed his skills at Nobel laureate Stanley Prusiner's lab at UCSF as an NIH postdoctoral fellow. Dr. Bredesen's academic career includes faculty positions at prestigious institutions like UCSF, UCLA, and UC San Diego. As the founding president and CEO of the Buck Institute for Research on Aging, he spearheaded pioneering work in the study of aging and neurodegenerative diseases. Currently, he serves as the chief medical officer of MPI Cognition, where he continues his innovative research and efforts to combat Alzheimer's and related conditions. Dr. Bredesen's expertise and leadership have made him a key figure in the field, with a focus on integrative approaches to prevent and reverse cognitive decline. His contributions are reshaping our understanding of neurodegenerative diseases, offering new hope for those affected by them. Website Instagram Take a Cognitive Assessment here: https://www.apollohealthco.com/know-your-cq/ Get a brain scan: https://getabrainscan.com/ KetoFLEX 12/3: https://www.trifectanutrition.com/apollohealthpartner Connect with me! Website Instagram Facebook YouTube This episode is sponsored by Professional Co-op®, where clinicians gain exceptional access to industry-leading lab services without the hefty price tag—since 2001, they've been redefining what efficient, patient-focused support looks like. Imagine no hidden fees, no minimums, and only paying for completed tests. Experience lab services that not only meet but also exceed your expectations. Join the co-op trusted by countless licensed clinicians nationwide. Visit www.professionalco-op.com to learn more! This episode is also made possible by Functional Medicine University. FMU is a fully online, self-paced training program in functional medicine, founded in 2006 by Dr. Ron Grisanti. With students in all 50 U.S. states and 68 countries globally, FMU has become a cornerstone in advanced clinical education for healthcare practitioners. The curriculum is led by Dr. Grisanti, alongside contributions from over 70 distinguished medical experts on FMU's advisory board. Graduates earn the prestigious Certified Functional Medicine Practitioner (CFMP®) credential upon completion. FMU is also a nationally approved provider of continuing education for a wide range of licensed professionals, including MDs, DCs, DOs, NDs, acupuncturists, PAs, NPs, nurses, dietitians, pharmacists, and dentists. Whether you're looking to expand your clinical knowledge or bring a functional approach to your practice, FMU offers the tools, guidance, and certification to help you thrive. Visit www.functionalmedicineuniversity.com to learn more!
Aging is the leading risk factor for cognitive decline, and projected statistics show that the number of people diagnosed with Alzheimer's will reach 8.5 million by 2030 and 11.2 million by 2040. Today, I am thrilled to connect with Dr. Heather Sandison, a naturopathic doctor and the founder and medical director of Solcere Health, a San Diego-based brain optimization clinic, and Marama, the first residential memory care facility that aims to return its residents to independent living. Dr. Sandison is also the New York Times bestselling author of Reversing Alzheimer's. In our conversation today, Dr. Sandison and I explored the most common signs of early cognitive decline, looking at ways to differentiate dementia from formal Alzheimer's disease. We dive into the causes of dementia and Alzheimer's, examining six key imbalances that can affect ApoE status and tackle the limitations of current approaches to Alzheimer's research. We also share information on current drug modalities and touch on the importance of brain-nurturing environments and helpful activities for maintaining cognitive status as we age. I look forward to having Dr. Sandison back for a second conversation, where we will dive deeper into practical ways to support and improve brain health. IN THIS EPISODE YOU WILL LEARN: Some early signs of neurocognitive decline Barriers to care for those with dementia or Alzheimer's What differentiates dementia from Alzheimer's? Various factors that could cause Alzheimer's The role ApoE genetics play in Alzheimer's risk How addressing lifestyle factors can help prevent cognitive decline. The limitations of current Alzheimer's treatments How the results of clinical trials on the Bredesen intervention have shown significant improvements in cognitive function Why individualized treatments are essential for managing Alzheimer's and dementia Making healthy choices accessible and creating environments that support cognitive function The benefits of making positive changes in your daily life and taking small steps to enhance brain health Connect with Cynthia Thurlow Follow on X Instagram LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Connect with Dr. Heather Sandison On her website Facebook, Instagram, and YouTube
View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this special episode of The Drive, Peter joins a unique conversation inspired by his daughter's volunteer experience at a senior care center, where she formed meaningful relationships with residents curious about healthspan, lifespan, and strategies for living well as they age. Peter engages directly with the residents, covering critical topics like the profound impact of exercise—particularly strength training— for maintaining mobility, preventing falls, and preserving independence later in life. He also discusses the importance of nutrition, emphasizing adequate protein intake, along with strategies for sleep optimization and preservation of brain health. Peter also underscores the importance of emotional wellness, purpose, and social connections in healthy aging, provides advice on staving off chronic disease, and much more. We discuss: Peter's definition of longevity [2:30]; Why it's never too late to invest in your longevity [5:30]; The importance of adding “life to years” rather than just “years to life” [7:45]; The "four horsemen"—heart disease, cancer, neurodegenerative diseases, and metabolic conditions [9:15]; Advice for those managing chronic diseases later in life [11:30]; Why balance declines and falls become increasingly common with age, and how to prevent them [13:30]; Why strength training is essential (and effective) for older adults [18:30]; The five tools in Peter's longevity toolkit [21:00]; Practical ways older adults can safely begin exercising despite physical limitations or health issues [23:00]; Principles of good nutrition, and the importance of adequate protein intake [24:00]; The importance of sleep for cognitive health, and effective sleep-improvement strategies for seniors [27:30]; How emotional health, social connections, and a sense of purpose significantly impact quality of life and longevity [32:00]; Why Peter decided to focus his work on longevity [33:45]; Protein intake recommendations should be based on ideal body weight (not current weight) [34:45]; The potential of klotho as a therapy for improving cognitive function and combating aging-related cognitive decline [35:30]; The best types of protein supplements to consider [36:45]; The APOE gene's influence on Alzheimer's disease risk, and why everyone should proactively address brain health, regardless of genetics [38:15]; How falls can accelerate cognitive decline, and the importance of staying physically and mentally active [40:45]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube
The FiltrateJoel TopfSwapnil HiremathAC GomezSopia AmbrusoNayan AroraSpecial Guests Michelle Rheault, Director, Division of Pediatric Nephrology, Professor of MedicineTiffany Caza, Nephropathologist, Scientist and self-described Freely Filtered fan girlEditing bySimon Topf and Sophia AmbrusoShow Notes10. Healthcare Cyberattacks9. ApoE in C3 glomerulonephropathy8. Workforce woes in Adult and Pediatric Nephrology7. Hyponatremia correction meta-analysis6. Microvascular inflammation increases risk of graft loss - in all of its forms5. Xenotransplantation4. KDIGO CKD Guidelines3. Hypertension control trials (ESPRIT, BPROAD)2. The Renaissance of IgAN: IgAN treatment trials1. FLOW: GLP-1 RAs in CKD
View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Tom Dayspring is a world-renowned expert in clinical lipidology and a previous guest on The Drive. In this episode, Tom explores the foundations of atherosclerosis and why atherosclerotic cardiovascular disease (ASCVD) is the leading cause of death worldwide for both men and women. He examines how the disease develops from a pathological perspective and discusses key risk factors, including often-overlooked contributors such as insulin resistance and chronic kidney disease. He breaks down the complexities of cholesterol and lipoproteins—including LDL, VLDL, IDL, and HDL—with an in-depth discussion on the critical role of apolipoprotein B (apoB) in the development of atherosclerosis. Additionally, he covers the importance of testing various biomarkers, the impact of nutrition on lipid levels, and the vital role of cholesterol in brain health, including how cholesterol is synthesized and managed in the brain, how it differs from cholesterol regulation in the rest of the body, and how pharmacological interventions can influence brain cholesterol metabolism. We discuss: Defining atherosclerotic cardiovascular disease (ASCVD): development, risks, and physiological impact [2:45]; The pathogenesis of ASCVD: the silent development over decades, and the importance of early detection for prevention of adverse outcomes [10:45]; Risk factors versus risk markers for ASCVD, and how insulin resistance and chronic kidney disease contribute to atherosclerosis [17:30]; How hyperinsulinemia elevates cardiovascular risk [24:00]; How apoB-containing lipoproteins contribute to atherosclerosis, and why measuring apoB is a superior indicator of cardiovascular risk compared to LDL cholesterol [29:45]; The challenges of detecting early-stage atherosclerosis before calcification appears [46:15]; Lp(a): structure, genetic basis, and significant risks associated with elevated Lp(a) [55:30]; How aging and lifestyle factors contribute to rising apoB and LDL cholesterol levels, and the lifestyle changes that can lower it [59:45]; How elevated triglycerides, driven by insulin resistance, increase apoB particle concentration and promote atherosclerosis [1:08:00]; How LDL particle size, remnant lipoproteins, Lp(a), and non-HDL cholesterol contribute to cardiovascular risk beyond apoB levels [1:21:45]; The limitations of using HDL cholesterol as a marker for heart health [1:29:00]; The critical role of cholesterol in brain function and how the brain manages its cholesterol supply [1:36:30]; The impact of ApoE genotype on brain health and Alzheimer's disease risk [1:46:00]; How the brain manages cholesterol through specialized pathways, and biomarkers to track cholesterol health of the brain [1:50:30]; How statins might affect brain cholesterol synthesis and cognitive function, and alternative lipid-lowering strategies for high-risk individuals [1:57:30]; Exciting advancements in therapeutics, diagnostics, and biomarkers coming in the next few years [2:09:30]; Recent consensus statements on apoB and Lp(a) from the National Lipid Association (NLA) [2:12:30]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube
Neurons have long enjoyed a kind of rock star status. We think of them as the most fundamental units of the brain—the active cells at the heart of brain function and, ultimately, at the heart of behavior, learning, and more. But neurons are only part of the story—about half the story, it turns out. The other half of the brain is made up of cells called glia. Glia were long thought to be important structurally but not particularly exciting—basically stage-hands there to support the work of the neurons. But in recent decades, at least among neuroscientists, that view has faded. In our understanding of the brain, glia have gone from stage-hands to co-stars. My guest today is Dr. Nicola Allen. Nicola is a molecular neuroscientist and Associate Professor at the Salk Institute in La Jolla, California. She and her lab study the role of glial cells—especially astrocytes—in brain function and dysfunction. Here, Nicola and I talk about how our understanding and appreciation of glial cells has changed. We do a bit of Brain Cells 101, reviewing the main division between neurons and glia and then sketching the subtypes within each category. We discuss the different shapes and sizes of glial cells, as well as the different functions. Glia are an industrious bunch. They're involved in synapse formation and pruning, the production of myelin, the repair of injuries, and more. We also talk about how glial cells have been implicated in various forms of brain dysfunction, from neurodegeneration to neurodevelopmental syndromes. And how, as a result, these cells are attracting serious attention as a site for therapeutic intervention. Well, it's that time of year again folks. Applications are now open for the 2025 Diverse Intelligences Summer Institute, or DISI. This is an intense program—highly interdisciplinary, highly international—for scholars and storytellers interested in all forms and facets of intelligence. If you like thinking about minds, if you like thinking about humans and animals and plants and AIs and collectives and ways they're alike and different—you would probably like DISI. For more info, check out disi.org—that's D-I-S-I dot org. Review of applications begins March 1st, so don't dally too too long. Alright friends—on to my conversation with Dr. Nicola Allen. Enjoy! Notes and links 3:00 – Correction: “glia” actually comes from the Greek—not the Latin—for “glue.” 3:30 – See this short primer on glia by Dr. Allen and Dr. Ben Barres. For a bit of the history of how glial cells were originally conceived, see this article on Ramón y Cajal's contributions to glia research. 10:00 – On the nascent field of “neuroimmunology,” see here. 14:00 – On the idea that “90% of brain cells are glia” see this article by (former guest) Suzana Herculano-Houzel. 18:00 – The root “oligo” in “oligodendrocyte” means “few” (and is thus the same as the “olig” in, e.g., “oligarchy"). It is not related to the “liga-” in “ligament.” 28:00 – On the idea that the glia-neuron ratio changes as brains grow more complex, see again the article by Dr. Herculano-Houzel. 30:00 – See Dr. Allen's paper on the idea of glia as “architects.” See also Dr. Allen's paper on the idea of glia as “sculptors.” 33:00 – See Dr. Allen's paper on the idea of the “tripartite synapse.” 42:00 – A recent paper reviewing the phenomenon of adult neurogenesis. 48:00 – See Dr. Allen's recent review of the role of astrocytes in neurodegeneration. 51:30 – A recent article on the roles of APOE in Alzheimer's. Recommendations Glia (2nd edition), edited by Beth Stevens, Kelly R. Monk, and Marc R. Freeman Many Minds is a project of the Diverse Intelligences Summer Institute, which is made possible by a generous grant from the John Templeton Foundation to Indiana University. The show is hosted and produced by Kensy Cooperrider, with help from Assistant Producer Urte Laukaityte and with creative support from DISI Directors Erica Cartmill and Jacob Foster. Our artwork is by Ben Oldroyd. Our transcripts are created by Sarah Dopierala. Subscribe to Many Minds on Apple, Stitcher, Spotify, Pocket Casts, Google Play, or wherever you listen to podcasts. You can also now subscribe to the Many Minds newsletter here! We welcome your comments, questions, and suggestions. Feel free to email us at: manymindspodcast@gmail.com. For updates about the show, visit our website or follow us on Twitter (@ManyMindsPod) or Bluesky (@manymindspod.bsky.social).
Can Alzheimer's really be optional? Join Dr. Dale Bredesen and Louisa Nicola as they dive into cutting-edge research and practical strategies to prevent cognitive decline. In this eye-opening episode, you'll discover why Alzheimer's doesn't have to be inevitable. Dr. Bredesen reveals the power of proactive steps—like advanced blood tests, genetic risk assessments, and lifestyle changes—that can reshape your brain health. From the role of the APOE gene to inflammation and detoxification, you'll learn how to take control of your cognitive future. If you're ready to challenge the narrative that Alzheimer's is unavoidable, this episode is for you. Momentous - Use code NEURO to get 20% off your order - https://www.livemomentous.com/neuro Maui Nui Venison - Use code NEURO to get 20% off https://mauinuivenison.com/pages/NEURO Timestamps 0:00 Alzheimer's Prevention Through Lifestyle and Supplements 3:02 Alzheimer's Disease as an Optional Condition Through Early Intervention 9:47 Maui Nui Venison Sticks: The Ultimate On-The-Go Protein Snack 12:05 Understanding Alzheimer's Disease and Its Underlying Causes 15:40 Understanding Alzheimer's as a Network Insufficiency and Its Causes 20:53 Metabolic Flexibility and Its Role in Cognitive Health 25:47 Lifestyle Factors and Genetic Risks in Alzheimer's Prevention 35:27 Inflammation's Role in Alzheimer's and Environmental Impact on Health 44:21 Tau and Amyloid as Antimicrobial Peptides in Alzheimer's Disease 49:56 Exploring Links Between MS, Alzheimer's, and Immune Responses 57:15 Reversing Alzheimer's Through Nutrients, Detox, and Lifestyle Changes 1:04:51 Innovations in Brain Health and Alzheimer's Prevention *** The Neuro Athletics Newsletter: https://bit.ly/3ewI5P0 Instagram: https://www.instagram.com/louisanicola_/ Twitter : https://twitter.com/louisanicola_ Learn more about your ad choices. Visit megaphone.fm/adchoices
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