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A New Podcast from Obstetrics & Gynecology, featuring members from the Editorial Team and contributing authors, each month as they highlight the latest research and practice updates in the field. This episode features an interview Dr. Taylor L. Pitt, author of “Prenatal Cannabis Use and Depressive Symptoms.”
Un nouvel épisode du Pharmascope est disponible… Et on aborde encore l'andropause et son traitement! Dans cette deuxième partie, Nicolas, Isabelle et Olivier discutent des données d'efficacité et d'innocuité de la testostérone en contexte d'andropause. Les objectifs pour cet épisode sont les suivants: Discuter de la prise en charge pharmacologique de l'andropause Discuter des données d'efficacité de la testostérone en contexte d'andropause Discuter des données d'innocuité de la testostérone en contexte d'andropause Ressources pertinentes en lien avec l'épisode Série documentaire « L'andropause sans tabou ». Disponible sur l'EXTRA d'ICI TOU.TV TTrialsSnyder PJ, et coll.; Testosterone Trials Investigators. Effects of Testosterone Treatment in Older Men. N Engl J Med. 2016 Feb 18;374(7):611-24. Resnick SM, et coll. Testosterone Treatment and Cognitive Function in Older Men With Low Testosterone and Age-Associated Memory Impairment. JAMA. 2017 Feb 21;317(7):717-727. Roy CN, et coll. Association of Testosterone Levels With Anemia in Older Men: A Controlled Clinical Trial. JAMA Intern Med. 2017 Apr 1;177(4):480-490. TRAVERSELincoff AM, et coll; TRAVERSE Study Investigators. Cardiovascular Safety of Testosterone-Replacement Therapy. N Engl J Med. 2023 Jul 13;389(2):107-117. Pencina KM, et coll. Effect of Testosterone Replacement Therapy on Sexual Function and Hypogonadal Symptoms in Men with Hypogonadism. J Clin Endocrinol Metab. 2024 Jan 18;109(2):569-580. Bhasin S, et coll. Depressive Syndromes in Men With Hypogonadism in the TRAVERSE Trial: Response to Testosterone-Replacement Therapy. J Clin Endocrinol Metab. 2024 Jun 17;109(7):1814-1826. Pencina KM, et coll. Efficacy of Testosterone Replacement Therapy in Correcting Anemia in Men With Hypogonadism: A Randomized Clinical Trial. JAMA Netw Open. 2023 Oct 2;6(10):e2340030. Snyder PJ, Bauer DC, Ellenberg SS, Cauley JA, Buhr KA, Bhasin S, Miller MG, Khan NS, Li X, Nissen SE. Testosterone Treatment and Fractures in Men with Hypogonadism. N Engl J Med. 2024 Jan 18;390(3):203-211. Autres référencesLee H, et coll. Testosterone replacement in men with sexual dysfunction. Cochrane Database Syst Rev. 2024 Jan 15;1(1):CD013071. Domes T, et coll. Canadian Urological Association guideline: Erectile dysfunction. Can Urol Assoc J. 2021 Oct;15(10):310-322. Buvat J, et coll. Hypogonadal men nonresponders to the PDE5 inhibitor tadalafil benefit from normalization of testosterone levels with a 1% hydroalcoholic testosterone gel in the treatment of erectile dysfunction (TADTEST study). J Sex Med. 2011 Jan;8(1):284-93. Walther A, Breidenstein J, Miller R. Association of Testosterone Treatment With Alleviation of Depressive Symptoms in Men: A Systematic Review and Meta-analysis. JAMA Psychiatry. 2019 Jan 1;76(1):31-40. Wittert G, et coll. Testosterone treatment to prevent or revert type 2 diabetes in men enrolled in a lifestyle programme (T4DM): a randomised, double-blind, placebo-controlled, 2-year, phase 3b trial. Lancet Diabetes Endocrinol. 2021 Jan;9(1):32-45. Bhasin S, et coll. Effect of Testosterone on Progression From Prediabetes to Diabetes in Men With Hypogonadism: A Substudy of the TRAVERSE Randomized Clinical Trial. JAMA Intern Med. 2024 Apr 1;184(4):353-362.
High adherence to the Mediterranean diet (MD) has been associated with a reduced risk of depression in prospective cohort studies, but whether MD interventions are effective among adults with depression is uncertain. Join us this episode for a conversation with Rubén Fernández-Rodríguez, co-author of this week's featured article.
Do you ever feel like your emotions are too much to handle?Rejection Sensitive Dysphoria (RSD) is a powerful yet often overlooked aspect of ADHD, particularly in women. If you've ever wondered whether your emotional turbulence is more than just "in your head," you're not alone. Many people with ADHD experience RSD, but it's frequently misunderstood - especially among women.In this episode, we're going to have an honest chat about RSD and how it relates to ADHD. We'll explore why those of us with ADHD often feel things so intensely, and why criticism or perceived rejection can hit us hard. It's not just "being too sensitive" - it's a real part of how our brains work.We'll also talk about how RSD can make us perfectionists, always striving to do better but never feeling quite good enough. If you've ever felt like an imposter in your own life, we'll discuss why that might be happening and how it connects to your ADHD.But we won't just talk about the challenges. We'll also share some ways to cope with these intense emotions. From therapy techniques like DBT and CBT to mindfulness practices and medication options.This episode is designed to bring awareness, understanding, and support to those navigating the emotional landscape of ADHD.Resources:Rejection Sensitive Dysphoria Symptom Test for AdultsEmotional RegulationRejection Sensitivity and Depressive Symptoms in WomenNew Insights Into Rejection Sensitive DysphoriaLearn more by connecting with Tracy through Instagram, Facebook, LinkedIn, Pinterest, or visit adhdforsmartwomen.com.Are You Ready to Discover Your Brilliance? Order Now: https://adhdforsmartwomen.com/bookJoin Your ADHD Brain is A-OK: https://adhdforsmartwomen.com/aokVisit our website: https://adhdforsmartwomen.comJoin our community of ADHD For Smart Ass Women: https://www.facebook.com/groups/tracyotsukaJoin What Do I Do With My Life Masterclass:,spyhappy.me/classUnlock your best days with Blends:,https://adhdforsmartwomen.com/blendsYour Name | Email | MessageGet a whole year of Blends for just $47 at adhdforsmartwomen.com/go.
With the plethora of digital CBT apps and programs available, how do you select one that's effective, safe, and engaging for teens? In this webinar Dr. Mirjana Subotic-Kerry, Senior Research Program Manager at Black Dog Institute delves into her research on digital cognitive behavioural therapy (CBT) and its impact on teen mental health.Mirjana shares the latest research findings and insights on navigating interventions to ensure they're evidence-based and prioritise the safety of teens' data and privacy, among other considerations. She introduces the new app ClearlyMe.You can find the slides here.
The latest report from the Growing up in Ireland study published today has found that today's teens smoke and drink less than their counterparts a decade ago but they are substantially more at risk of depressive symptoms. Today's study is tracking the opinions of 6,000 13 years olds. For reaction on this Mark Smyth, Chartered Clinical Psychologist
How many patients maintain weight loss 1 year after discontinuing semaglutide or liraglutide? Find out about this and more in today's PeerDirect Medical News Podcast.
DOI: 10.13056/acamh.30278 In this Papers Podcast, Dimitris Tsomokos discusses his JCPP Advances paper ‘Chronotype and depression in adolescence: Results from a UK birth cohort study' (https://doi.org/10.1002/jcv2.12245). Dimitris is the first author of the paper. There is an overview of the paper, methodology, key findings, and implications for practice. Discussion points include: The bidirectional association between sleep duration and sleep quality and depressive symptoms in adolescence. The reason behind using the Millennium Cohort Study (MCS), a large, population-based longitudinal birth cohort, in the study. The cross-sectional association between chronotype and depressive symptoms and the differences between the sexes. Can a ‘sleep catch-up mechanism' mitigate risk for depression and are adolescence that are in tune with their circadian rhythms at less risk of depression? The implications for policymakers and child and adolescent mental health professionals. Gender differences and eveningness. In this series, we speak to authors of papers published in one of ACAMH's three journals. These are The Journal of Child Psychology and Psychiatry (JCPP); The Child and Adolescent Mental Health (CAMH) journal; and JCPP Advances. #ListenLearnLike
In this episode of Rena Malik, M.D., we delve into the fascinating world of estrogen and its impact on neurotransmitters, including its role in regulating mood, cognitive function, and depression. Dr. Malik provides insights into the connection between estrogen receptors in the brain, serotonin, and noradrenaline, shedding light on how estrogen can positively influence mood and potentially act as a mood stabilizer. Additionally, we explore the effects of estrogen on heart health, vasomotor symptoms experienced during menopause, and the potential benefits of hormone therapy within the first 10 years of menopause onset. Join us as we uncover the multifaceted influence of estrogen on the brain and overall well-being. Become a Member to Receive Exclusive Content: renamalik.supercast.com Schedule an appointment with me: https://www.renamalikmd.com/appointments ▶️Chapters: 00:00 Estrogen and Neurotransmitter Regulation 01:04 Impact of Estrogen on Serotonin and Noradrenaline 02:13 Estrogen's Effect on Serotonin Production 02:55 Increased Risk of Depressive Symptoms in Perimenopausal Women 02:55 Study on Estradiol Treatment for Depressive Symptoms 04:40 Estrogen's Role in Cardiovascular Health 05:57 Hormone Therapy for Heart Disease Prevention 07:27 Vasomotor Symptoms in Menopause Let's Connect!: WEBSITE: http://www.renamalikmd.com YOUTUBE: https://www.youtube.com/@RenaMalikMD INSTAGRAM: http://www.instagram.com/RenaMalikMD TWITTER: http://twitter.com/RenaMalikMD FACEBOOK: https://www.facebook.com/RenaMalikMD/ LINKEDIN: https://www.linkedin.com/in/renadmalik PINTEREST: https://www.pinterest.com/renamalikmd/ TIKTOK: https://www.tiktok.com/RenaMalikMD ------------------------------------------------------ DISCLAIMER: This podcast is purely educational and does not constitute medical advice. The content of this podcast is my personal opinion, and not that of my employer(s). Use of this information is at your own risk. Rena Malik, M.D. will not assume any liability for any direct or indirect losses or damages that may result from the use of information contained in this podcast including but not limited to economic loss, injury, illness or death. Learn more about your ad choices. Visit megaphone.fm/adchoices
Ever wondered how much control you have over being happy? Scientists say your genes play a big part, but there's plenty you can do to boost your mood. Dr. Wendy shares 7 simple tips parents can use to have a happy family. Discover how spending time with others, having family meals, and choosing certain foods can make you feel happier. Read the Episode Transcript References Beezhold, B.L., Johnston, C.S., 2012. Restriction of meat, fish, and poultry in omnivores improves mood: a pilot randomized controlled trial. Nutrition Journal. 11 (9). Wolniczak I et al., 2017. Fruits and vegetables consumption and depressive symptoms: A population-based study in Peru. PLoS One. 12 (10) e0186379. Kontogianni MD, Vijayakumar A, Rooney C et al. 2020. A high polyphenol diet improves psychological well-being: the polyphenol intervention trial (PPhIT). Nutrients. 12 (8) 2445. Walsh H, Lee M and Best T. 2023. The Association between Vegan, Vegetarian, and Omnivore Diet Quality and Depressive Symptoms in Adults: A Cross-Sectional Study. International Journal of Environmental Research and Public Health. 20 (4) 3258. Send your questions to hello@pediatriciannextdoorpodcast.com or submit at drwendyhunter.com Find products from the show on the shop page. *As an Amazon Associate, I earn commission from qualifying purchases. More from The Pediatrician Next Door: Website: drwendyhunter.com Instagram: @the_pediatrician_next_door Facebook: facebook.com/wendy.l.hunter.75 TikTok: @drwendyhunter LinkedIn: linkedin.com/in/drwendyhunter This is a Redd Rock Music Podcast IG: @reddrockmusic www.reddrockmusic.com Learn more about your ad choices. Visit megaphone.fm/adchoices
The winter season can find many of us in a bit (or a lot) of a lower mood, lower energy, and more negative thinking patterns. Some of us are even affected by SAD or Seasonal Affective Disorder where we experience depressive symptoms. By focusing on optimizing our circadian rhythm we can decrease symptoms of SAD, increase our mood and energy and even drop a few pounds. Take a listen to learn how. https://heatherheynen.com Follow me: @heynencounselingandcoaching & @peakproteinrecipes Link to my Online Course: End Binge Eating, Overeating & Emotional Eating For Good https://heather-heynen-s-school.teachable.com/p/mindful-eating-mastery-overcome-binge-eating-over-eating-emotional-eating Link to my Online Course: When You're Ready To Stop The Weight Loss Medication: A Comprehensive Guide To Natural Weight Maintenance & Mastery http://heather-heynen-s-school.teachable.com/p/weight-maintenance-mastery-exactly-how-to-keep-the-weight-off-after-drug-based-weight-loss Link to my ebook High Protein, Easy Recipes: https://heather-heynen-s-school.teachable.com/p/my-downloadable-526153 Please support this show's sponsors: 5Strands: Affordable, easy food intolerance testing for humans and pets! https://www.5strands.com/#HeatherHeynen. Enter Discount Code HeatherHeynen at checkout The Amino Co. Amino acid supplements to help meet your protein goals. Highlight and open this link for 30% off your order. http://aminoco.com/HH30 PhysiVantage: The Best Whey Protein, Collagen & More! https://physivantage.com/ Enter Discount Code FRIENDS15 at checkout The information in this podcast is intended to provide broad understanding and knowledge of healthcare topics. This information is for educational purposes only and should not be considered complete and should not be used in place of advice from your physician or healthcare provider. We recommend you consult your physician or healthcare professional before beginning or altering your personal exercise, diet or supplementation program. --- Send in a voice message: https://podcasters.spotify.com/pod/show/heather1422/message Support this podcast: https://podcasters.spotify.com/pod/show/heather1422/support
ROLANDE is bringing you niggas STATS for the holidays!!!! She talks Demystifying research the harms of not doing your research a short intro to descriptive research and correlations, y'know? so you can stay educated about the world around you being (begrudgingly) grateful for Emory feelings vs. logic (intuition vs. science & evidence & proof) The importance of Black research!!!! WOMANISM I LOVE YOU MY BLACK WOMEN! STAY EMOTIONALLY, PHYSICALLY, PSYCHOLOGICALLY, AND SPIRITUALLY SAFE! REFERENCES Jasmine A. Abrams, Ashley Hill, & Morgan Maxwell; Underneath the Mask of the Strong Black Woman Schema: Disentangling Influences of Strength and Self-Silencing on Depressive Symptoms among U.S. Black Women. Sex Roles 80, 517–526 (2019). https://doi.org/10.1007/s11199-018-0956-y --- Send in a voice message: https://podcasters.spotify.com/pod/show/rolande5/message Support this podcast: https://podcasters.spotify.com/pod/show/rolande5/support
Sick vs. healthy muscle. (2:36) The best test for looking at the health of skeletal muscle. (8:30) The difference between fat and its influence on your hormones. (10:20) Why the way we have intellectualized medicine is backwards! (15:00) “The wider the waistline, the lower the brain volume.” (20:57) Why you are never too old to build muscle. (25:02) Why the food pyramid is the worst social experiment we've ever had. (29:52) Going down the scary direction of becoming more planet-based from animal-based sources. (31:50) Have we been misled with sodium? (39:18) Does fasting affect men and women differently? (40:54) Diagnosing the different avatars she sees in her practice. (46:02) Concierge vs. Western medicine. (54:52) The misconception that physicians are paid to prescribe. (57:04) Should people stop seeing their doctor if they're obese? (59:00) Her take on GLP-1 antagonists/semaglutide. (1:00:51) Her favorite peptides and why. (1:10:10) The newest technology available for providers to look at skeletal muscle health. (1:12:29) The different training archetypes. (1:17:38) The resistance training revolution is here! (1:21:50) Related Links/Products Mentioned Forever Strong Summit - January 14, 2024 in Austin, TX For a limited time only, Mind Pump listeners get a free LMNT Sample Pack with any purchase: Visit DrinkLMNT.com/MindPump Special Launch: MAPS 40+ ** Code 40LAUNCH at checkout ** Promotion ends December 24th, act now for $80 off + 2 FREE eBooks! December Promotion: MAPS Old Time Strength | MAPS OCR 50% off! ** Code DECEMBER50 at checkout ** Forever Strong: A New, Science-Based Strategy for Aging Well – Book by Dr. Gabrielle Lyon D3 -Creatine dilution and the importance of accuracy in the assessment of skeletal muscle mass Effects of Dietary Protein on Body Composition in Exercising Individuals The Association between Vegan, Vegetarian, and Omnivore Diet Quality and Depressive Symptoms in Adults: A Cross-Sectional Study Research finds semaglutide treatment is associated with remarkable reductions in alcohol use disorder symptoms Mind Pump #2192: Dr. Jordan Shallow & Dr. Adeel Khan The Resistance Training Revolution – Book by Sal Di Stefano Mind Pump Podcast – YouTube Mind Pump Free Resources Featured Guest/People Mentioned Dr. Gabrielle Lyon (@drgabriellelyon) Instagram Bret H. Goodpaster, PhD | AdventHealth Research Institute Layne Norton, Ph.D. (@biolayne) Instagram Adeel Khan, MD (@dr.akhan) Instagram Jordan Shallow D.C (@the_muscle_doc) Instagram DON SALADINO (@donsaladino) Instagram Bedros Keuilian (@bedroskeuilian) Instagram
Dr. Luis Farhat and Dr. Guilherme V. Polanczyk (University of São Paulo, Brazil) join AJP Audio to discuss the impact of socioenviromental factors, emotional dysregulation, and other factors impact neurodevelopment in children. Afterwards, we'll once again be joined by American Journal of Psychiatry Editor-in-Chief, Dr. Ned Kalin, to discuss the rest of the September issue of AJP and what brings it together. Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Stitcher, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org
Medycyna stylu życia to nowa, rozwijająca się gałąź medycyny u której podstaw leży styl życia, który pełni kluczową rolę w profilaktyce i leczeniu chorób. Warto dodać, że jest to część medycyny konwencjonalnej, opartej o badania naukowe i kliniczne. Medycyna stylu życia patrzy na pacjenta przez pryzmat – aktywności fizycznej, tego co je, jak śpi, jak reaguje na stres, jakie ma relacje z otoczeniem. Celem lekarz medycyny stylu życia jest w oparciu o strategie oparte na dowodach, pomóc mu wdrożyć trwale zdrowotnie nawyki, a tym samym wydłużyć jego życie w zdrowiu. Gość: dr n. med. Joanna Ludwikowska – specjalistka Radiologii i Diagnostyki Obrazowej oraz certyfikowany lekarzem Medycyny Stylu Życia amerykańskiego International Board of Lifestyle Medicine. Ponadto Asia ukończyła certyfikowany kurs Mindfulness. Asia z pacjentami pracuje indywidualnie w nurcie psychologii pozytywnej. Jej misją jest pokazanie ścieżki do zdrowia, energii oraz równowagi psychicznej i fizycznej w oparciu o dowody naukowe. Asię znajdziecie na instagramie pod nickiem @dr_joanka oraz stronie internetowej: www.drjoanka.pl W odcinku znajdziesz odpowiedzi m. in. na następujące pytania: Czym jest medycyna stylu życia? Czym są filary medycyny stylu życia? Jakim chorobom możemy zapobiegać poprzez styl życia? Czym się różni medycyna stylu życia od medycyny funkcjonalnej i biohackingu? Dlaczego w dzisiejszych czasach nie możemy się porządnie wyspać? Jak opanować stres na co dzień życia? Czym jest Mindfulness i czy zmienia on strukturę naszego mózgu? Czym jest Shirin Yoku i jak wpływa na nasze zdrowie? Dlaczego sen jest ważny z punktu profilaktyki zdrowia? Dlaczego w dzisiejszych czasach nie możemy się porządnie wyspać? Jak opanować stres na co dzień życia? Lista publikacji o których wspominamy w podcaście: Medycyna stylu życia. Redakcja naukowa: Daniel Śliż, Artur Mamcarz, PZWL Wydawnictwo Lekarskie, Warszawa 2018 Antonelli M. i wsp. Effects of forest bathing (shinrin-yoku) on individual well-being: an umbrella review. Int J Environ Health Res. 2022 Aug;32(8):1842-1867. Kim H. i wsp. Effect of Forest Therapy for Menopausal Women with Insomnia. Int J Environ Res Public Health 2020, 17:18. Kim H. i wsp. An Exploratory Study on the Effects of Forest Therapy on Sleep Quality in Patients with Gastrointestinal Tract Cancers. Int J Environ Res Public Health 2019, 16:14. Lee I. i wsp. Effects of Forest Therapy on Depressive Symptoms among Adults: a Systematic Review. Int J Environ Res Public Health 2017, 14:3. White M.P. i wsp. Spending at least 120 minutes a week in nature is associated with good health and wellbeing. Scientific Reports. 9 (1): 2019. Meredith GR. I wsp.. Minimum Time Dose in Nature to Positively Impact the Mental Health of College-Aged Students, and How to Measure It: a Scoping Review. Frontiers in Psychology 2019, 10:2942. Cappuccio F.P. i wsp. Sleep duration and all-cause mortality: a systematic review and meta-analysis of prospective studies. Sleep 2010 May;33(5):585-92. Sabia S. i wsp. Association of sleep duration in middle and old age with incidence of dementia. Nat Commun. 2021; 12: 2289 Garbarino S. i wsp. Role of sleep deprivation in immune-related disease risk and outcomes. Commun Biol. 2021 Nov 18;4(1):1304. Panda S. Śpij, jedz i ruszaj się zgodnie ze swoim rytmem okołodobowym. Wydawnictwo Feeria Łódź 2020. Hölzel B.K. i wsp. Mindfulness practice leads to increases in regional brain gray matter density. Psychiatry Res. 2011 Jan 30; 191(1): 36–43. Gotink R. A. i wsp. 8-week Mindfulness Based Stress Reduction induces brain changes similar to traditional long-term meditation practice - A systematic review. Brain Cogn. 2016 Oct; 108:32-41.
Dr. Julia Rowland shares the newest evidence-based recommendations from SIO and ASCO on integrative therapies for managing anxiety and depression symptoms in adults with cancer. Listen in to hear recommended options, such as acupuncture, aromatherapy, hypnosis, mindfulness, music therapy, relaxation, reflexology, Tai Chi and/or Qigong, and yoga. Dr. Rowland also discusses therapies the panel investigated but found insufficient evidence to support a recommendation for use in treating anxiety and depression. We also review how this guideline complements the recent ASCO guideline on conventional therapies for managing anxiety and depression, and the impact for patients and clinicians. Read the full guideline, "Integrative Oncology Care of Symptoms of Anxiety and Depression in Adults with Cancer: SIO-ASCO Guideline" at www.asco.org/survivorship-guidelines TRANSCRIPT This guideline, clinical tools, and resources are available at www.asco.org/survivorship-guidelines. Read the full text of the update and review authors' disclosures of potential conflicts of interest disclosures in the Journal of Clinical Oncology, https://ascopubs.org/doi/10.1200/JCO.23.00857 Brittany Harvey: Hello and welcome to the ASCO Guidelines Podcast, one of ASCO's podcasts delivering timely information to keep you up to date on the latest changes, challenges, and advances in oncology. You can find all the shows, including this one, at asco.org/podcasts. My name is Brittany Harvey and today I'm interviewing Dr. Julia Rowland from the Smith Center for Healing in the Arts, Co-chair on “Integrative Oncology Care of Anxiety and Depressive Symptoms in Adult Patients with Cancer: Society for Integrative Oncology – American Society of Clinical Oncology Guideline.” Thank you for being here, Dr. Rowland. Dr. Julia Rowland: Lovely to be here, Brittany. Thanks for this opportunity. Brittany Harvey: We're glad to have you on. Then before we discuss this guideline, I'd just like to note that ASCO takes great care in the development of its guidelines and ensuring that the ASCO conflict of interest policy is followed for each guideline. The disclosures of potential conflicts of interest for the guideline panel, including the guest on this episode, are available in line with the publication of the guideline in the Journal of Clinical Oncology, which is linked in the show notes. So then I'd like to jump into the content of this guideline. So Dr. Rowland, what is the purpose of this joint SIO and ASCO guideline? Dr. Julia Rowland: The purpose of the joint guideline, Brittany, published in the Journal of Clinical Oncology is to provide evidence-based recommendations to healthcare providers on integrative approaches to managing anxiety and depression symptoms in their adult cancer patients. By integrative approaches, we mean such interventions as yoga, relaxation, hypnosis, mindfulness, acupuncture, music therapy in treating anxiety and depression. Many of these therapies are already being used by people with cancer both during and after their treatment, with rates increasing over time. While use of integrative interventions can serve to improve quality of life, reduce stress, and provide individuals with a sense of control over their health, and they're often reported by patients as doing just that, it's important to note that for the purpose of this guideline, we examine specifically the ability of these interventions to significantly reduce symptoms of anxiety and depression. Brittany Harvey: Great. And then, as you just mentioned, this guideline covers both anxiety and depression. So then I'd like to review the recommendations made by the expert panel and we'll go in order of those. So starting with those recommendations for anxiety, what integrative therapies are recommended for managing symptoms of anxiety experienced after diagnosis or during active treatment? Dr. Julia Rowland: The strongest recommendations in the guideline are for the use of mindfulness-based interventions, which include mindfulness-based stress reduction, meditation, and mindful movement. These interventions were recommended across the board to treat both anxiety and depression symptoms in patients in active treatment, and those post-treatment due to the strong evidence to show their benefits to patients. Yoga was also recommended for patients with breast cancer to treat both anxiety and depression symptoms, although the strength of the evidence was moderate. Data was less compelling for its use during or after treatment in other cancers, likely due to the lack of small numbers of non-breast cancer survivors included in study samples. There was also evidence for the use of relaxation, music therapy, and reflexology for treating anxiety symptoms during active treatment, and that the use of hypnosis and aromatherapy using inhalation were of modest to some benefit during diagnostic or treatment procedures. Brittany Harvey: Understood. Thank you for reviewing those recommendations. And you already mentioned a few items that are helpful and recommended for adults with cancer experiencing anxiety post-treatment, but which additional integrative therapies are recommended for this patient population? Dr. Julia Rowland: In addition to mindfulness-based interventions and yoga, acupuncture, Tai Chi, and/or Qigong, and reflexology are recommended for treating anxiety symptoms post-treatment. Brittany Harvey: Excellent. Thank you for that summary of recommendations. So then, moving into the recommendations on depression, what does the expert panel recommend for adults with cancer experiencing symptoms of depression? Dr. Julia Rowland: For depression symptoms during treatment, the panel recommended mindfulness-based interventions, yoga, music therapy, relaxation, and reflexology, while post-treatment mindfulness-based interventions, yoga, and Tai Chi or Qigong were recommended. Brittany Harvey: Excellent. Thank you for reviewing all the recommendations that the panel put forward. So this guideline reviewed a large breadth of integrative therapies. Are there any therapies that the panel reviewed but couldn't make a recommendation for, for this particular guideline? Dr. Julia Rowland: Thank you for asking that question because as people listen to this podcast, they may realize that there are some therapies that may be widely used by their population or in their center or clinic, including such things as natural products and supplements, melatonin, healing touch, massage, light therapy, to name a few. Where the panel found in its review of the literature of over 110 studies or systematic reviews, there was insufficient evidence for the vast majority of these to make any conclusive recommendation. It just means we have a lot more work to do in assessing the efficacy of these, especially in treating anxiety and depression. One intervention stands out in particular that's widely used and that's expressive writing. While this may be very helpful for improving quality of life or making sense of the cancer experience and providing an outlet for self-expression, the data does not support its use for treating anxiety and depression. It may be because it's too brief an intervention for conditions that have more depth and permanence. It doesn't mean you can't use it for other purposes, but the panel did not recommend its use for treating anxiety and depression. Brittany Harvey: Understood. That makes sense that there are some integrative therapies that work across different parts of the treatment spectrum and that there are some areas in which we just don't have the evidence yet. So, thank you for reviewing all of those recommendations. So then, how does this guideline complement the recently published ASCO Guideline on the Management of Anxiety and Depression in Adult Survivors of Cancer? Dr. Julia Rowland: That's a terrific question. The recently published ASCO Guideline on Management of Anxiety and Depression in Adult Cancer Survivors represents an update of our original 2014 guideline. The ASCO guideline provided recommendations regarding the use of conventional therapies, psychological, behavioral, and psychopharmacologic interventions for managing anxiety and depression. The current SIO and ASCO guidelines sought to expand upon and essentially complement these recommendations by identifying those integrative therapies that might also be effective in the management of anxiety and depression in adults treated for cancer. Further, the SIO and ASCO guidelines attempted to determine when, in the course of care, during diagnosis and active treatment and/or post-treatment, these interventions worked best. Both sets of recommendations strongly endorse the benefits of mind-body interventions in addressing both anxiety and depression, specifically mindfulness-based interventions in this SIO and ASCO guideline and cognitive, behavioral, behavioral activation, and mindfulness-based stress management programs in the ASCO guideline. Brittany Harvey: It's great to have these complementary guidelines available at the same time for a complete approach to managing anxiety and depression during treatment and post-treatment. So then, in your view, Dr. Rowland, what is the importance of this guideline and how will it impact clinicians and patients with symptoms of anxiety and/or depression? Dr. Julia Rowland: Brittany, cancer takes a significant psychological toll on affected individuals. Research has shown that cancer survivors have a significantly elevated risk of developing mental health disorders compared with the general population. Despite this, their psychological symptoms are often under-recognized and undertreated. As the number of cancer survivors continues to grow, so does the challenge to healthcare providers of meeting their mental health needs. Anxiety and depression symptoms have long been associated with lower quality of life and higher mortality in people with cancer. Treating symptoms of anxiety and depression using evidence-based, integrative therapies has the potential to not only improve patients' quality of life and help them better manage their care but may also improve length of life. With the publication of this guideline, we now know which therapies could have the biggest impact. An added benefit of incorporating, or at least considering, integrative therapies to manage anxiety and depression are that they have few, if any, side effects, can be readily modified to accommodate individuals with multiple comorbidities, are well received by the majority of patients, and can be received in a variety of settings, including at home and online. Brittany Harvey: Those are key points that you just made. These recommendations are key for improving quality of life for patients, and it's great to have options for patients, including, as you mentioned, at home. So then finally, what are the outstanding questions for the use of integrative approaches in managing anxiety and depression in patients with cancer? Dr. Julia Rowland: As I look at these new guidelines, both the SIO and ASCO, as well as the renewed ASCO guidelines, perhaps the biggest question raised is how to increase the use of recommended care. And I think there are three parts to this challenge. One critical first part is raising awareness about these guidelines, which it's hoped this podcast will help us achieve. A second, equally critical step, however, is identifying available treatment resources. While most treatment clinics and centers have access to mental health resources in a number of settings, this may be quite limited. Further, it's not clear how many such programs include integrative programs and services. In addition to the questions about availability, lack of familiarity with some of these therapeutic modalities may leave clinicians reluctant to refer their patients for such care and raise questions for them about how to assess the training and qualifications of integrative care providers and the rigor of the therapy they provide. An important recommendation made by both ASCO and the SIO and ASCO Anxiety and Depression Management Guideline panels is that oncology clinicians should conduct a landscape analysis of who is and what types of programs are available to provide the recommended therapies to their patients. Arguably, not knowing where to refer a patient suffering from anxiety and depression is the most significant area to that patient's receipt of optimal care. The landscape review should include in-house or affiliated mental health providers, integrative program leads if present, local professionals, and organizations offering this care, as well as access to community-wide and national groups providing integrative care remotely via online and telephone. Asking patients themselves who they have seen and found helpful in improving their emotional well-being can also broaden resource lists generated. A third challenge is how best to identify and refer those patients most in need. Recommendations regarding screening and assessment of anxiety and depression were not within the scope of the SIO and ASCO guidelines. However, in the two published ASCO Guidelines on use of conventional interventions for managing anxiety and depression, both the 2014 original and the updated 2023 revised, the expert panels emphasize the critical need to routinely screen for both anxiety and depression using standardized measures such as the GAD-7 and the PHQ-9. ASCO's QOPI or Quality Oncology Practice Initiative already includes screening for emotional distress early in the course of care as a key practice standard. Other appropriate times for screening include changes in disease or treatment status, transition to palliative and end-of-life care, and when clinically indicated. Screening is the critical and necessary first step to identification and referral for appropriate and timely care of cancer patients and survivors suffering from anxiety and depression. Figuring out how to do this well and systematically should be a priority for reducing the burden of cancer nationally. Brittany Harvey: Absolutely. As you mentioned, screening is critical for identifying patients experiencing anxiety and depression, and I appreciate you reviewing those implementation barriers and how clinicians and practices can work to reduce these barriers and increase the uptake of these recommendations. We'll have some of those resources linked in the guideline also on the ASCO website and in the show notes of this episode. So I want to thank you so much for your insights on this guideline and for your time today, Dr. Rowland. Dr. Julia Rowland: My pleasure, Brittany. I hope the word gets out and we'll see more uptake of these affected therapies and in broader use. Thank you. Brittany Harvey: Definitely. That's the goal of all of these guidelines. I also want to thank all of our listeners for tuning into the ASCO Guidelines Podcast. To read the full guideline, go to www.asco.org/survivorship-guidelines. You can also find many of our guidelines and interactive resources in the newly redesigned ASCO Guidelines app available for free in the Apple App Store or the Google Play Store. If you have enjoyed what you've heard today, please rate and review the podcast, and be sure to subscribe so you never miss an episode. The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of medical conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.
Dr. Scott Eilers is a licensed and practicing clinical psychologist. He is the creator and director of multiple intensive outpatient programs for mood and anxiety disorders, as well as the author of the book “For When Everything Is Burning” and the host of the podcast “The Psychology of Depression and Anxiety.” In addition to traditional psychotherapy concepts, Dr. Eilers also draws inspiration from stoicism, minimalism, fitness, and nutritional psychiatry.In this episode, we explore different depressive symptoms, some misconceptions around mood disorders, how irritability can show up as a symptom, what depression in children may look like, and more.FOLLOW DR. EILERS:INSTAGRAM: @dr.scott.eilersPODCAST: The Psychology of Depression & AnxietyBOOK: For When Everything Is BurningSTAY CONNECTED:INSTA: @trustandthriveTIKOK:@trustandthriveTWITTER: @trustandthriveFACEBOOK: bit.ly/FBtaramontWEBSITE: www.tara-mont.com EMAIL: trustandthrive@gmail.com
On this week's ADHD Skills Lab Research Recap, Skye and Sarah look at the latest research on ADHD and middle childhood. They explore how ADHD is experienced during this period, look at the connection between common symptoms and struggles at different stages of life and ask whether ADHD can change over time. Unconventional Organisation: https://www.unconventionalorganisation.com/The ADHD Academy: https://courses.unconventionalorganisation.com/the-adhd-academy1:38 Genetic overlap between midfrontal theta signals and ADHD and ASD in a longitudinal twin cohorthttps://www.biologicalpsychiatryjournal.com/article/S0006-3223(23)01274-X/fulltext 11:46 Impairment's Role in the Pathway From Externalizing Psychopathology to Depressive Symptoms in Adolescents With ADHDhttps://journals.sagepub.com/doi/10.1177/10870547231159911 22:25 Predictors of Quality of Life and Functional Impairments in Emerging Adults With and Without ADHD: A 10-Year Longitudinal Studyhttps://journals.sagepub.com/doi/10.1177/10870547231153962
Docs Outside The Box - Ordinary Doctors Doing Extraordinary Things
Trigger Warning: If you are experiencing thoughts of harming yourself, please call 988 or text the word TALK to 741741 Crisis Helpline which are open 24/7. In this episode, we discuss the unfortunate passing of Dr. Nakita Mortimer, the effects of residency on mental health, and so much more. In this episode, we discuss: [04:00] Dr. Nakita Mortimer's unfortunate passing [06:56] The effects of residency on mental health [10:53] Dr. Nii's mental health journey during residency [19:55] Dr. Renee's mental health journey during residency[30:52] Why is this important? [42:18] What Dr. Renee would say to their kids if they decided they wanted to be a doctor [44:21] Dr. Nii's first experience with applying to med school [45:45] How the pursuit of becoming a doctor affects those in pre-med and beyond [48:44] Why so many doctors avoid seeking help [53:07] Dr. Nii's second and third year as a resident in the ICU [1:01:09] How medical programs can do better when it comes to prioritizing mental health[1:04:58] A message to the pre-meds and residents from Dr. Nii and Dr. Renee [1:10:44] The signout segment: Shannon Sharpe leaving FS1 + Be Your Girl (Kaytranada Edition) by Teedra MosesLinks Mentioned:Residency Program Factors Associated With Depressive Symptoms in Internal Medicine Interns: A Prospective Cohort Study Study: Prevalence of Depression, Depressive Symptoms, and Suicidal Ideation Among Medical Students (2016) Medscape Survey Phsician Suicide Report 2023 Join our community:Text word PODCAST to 833-230-2860Twitter: @drniidarkoInstagram: @docsoutsidetheboxEmail: team@drniidarko.comPodcasting Course: www.docswhopodcast.comMerch: https://docs-outside-the-box.creator-spring.com
Author Cleothia Frazier discusses the article, "Working Around the Clock: The Association between Shift Work, Sleep Health, and Depressive Symptoms among Midlife Adults," published in the March 2023 issue of Society and Mental Health.
If I told you there was something that could support an improved memory, moods, and concentration; support a healthy weight and reduce the risk of cardiovascular disease and type two diabetes, and that this was just the short list of its benefits. Oh, and that it is available to everyone and completely free…would you want it? Well, friend, there is such a thing and it's called good sleep health. In today's Tuesday Terrain Talk, I'll fill you in on the current understanding of the value of sleep when it comes to supporting your health. By the end of this show, you'll be armed with valuable resources to help you create better sleep health with a clear understanding of why it's important to you and how it might be even more important for breast cancer survivors than those who have never had cancer to work on creating good sleep health. You may want to put an end to those late-night Netflix binges and start planning some regular early date nights with Mr. Sandman. Referred to in this episode: #74 The Healing Power of Sleep and What Happens when Sleep Goes Wrong-Part 1 #75 The Healing Power of Sleep and What Happens when Sleep Goes Wrong-Part 2 Harvard Sleep and Health Education Gateway Sleep and Health Education Program The Symptom Cluster of Sleep, Fatigue and Depressive Symptoms in Breast Cancer Patients: Severity of the Problem and Treatment Options Sleep Disorders and Sleep Deprivation: An Unmet Public Health Problem Eight Health Benefits of Sleep
In this Papers Podcast, Dr. Tone Hermansen discusses her JCPP Advances paper ‘Child internalizing and externalizing behaviors: Interplay between maternal depressive symptoms and child inhibitory control'.
Support this podcast at — https://redcircle.com/hypnosis-and-relaxation-sound-therapy9715/donationsAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
Drs John M. Kane and Christoph U. Correll discuss the importance of ongoing assessment of psychiatric comorbidities in patients with schizophrenia and its impact on outcomes and treatment decisions. Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/984483). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Schizophrenia https://www.medscape.com/resource/schizophrenia What Are the Major Metabolic and Neurologic Risks Associated With Antipsychotic Medications? https://www.medscape.com/viewarticle/969525 Trauma and Posttraumatic Stress Disorder (PTSD) in Patients With Schizophrenia or Schizoaffective Disorder https://pubmed.ncbi.nlm.nih.gov/19777347/ Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision (DSM-5-TR) https://www.psychiatry.org/psychiatrists/practice/dsm Relationship Between Obsessive Compulsive Symptomatology and Severity of Psychotic Symptoms in Schizophrenia: Meta-analysis and Meta-Regression Analysis https://pubmed.ncbi.nlm.nih.gov/36549240/ Clozapine-Induced Obsessive-Compulsive Symptoms: Mechanisms and Treatment https://pubmed.ncbi.nlm.nih.gov/30565908/ The Specific Phenotype of Depression in Recent Onset Schizophrenia Spectrum Disorders: A Symptom Profile and Network Comparison to Recent Onset Major Depressive Disorder Without Psychotic Features https://pubmed.ncbi.nlm.nih.gov/34942537/ Schizophrenia Comorbid With Panic Disorder: Evidence for Distinct Cognitive Profiles https://pubmed.ncbi.nlm.nih.gov/22417926/ Obsessive-Compulsive Disorder Comorbid With Schizophrenia and Bipolar Disorder https://pubmed.ncbi.nlm.nih.gov/30745688/ Depressive Symptoms in Schizophrenic Patients https://pubmed.ncbi.nlm.nih.gov/22112362/ Post-Psychotic Depression: An Updated Review of the Term and Clinical Implications https://pubmed.ncbi.nlm.nih.gov/35220306/ Mortality in People With Schizophrenia: A Systematic Review and Meta-analysis of Relative Risk and Aggravating or Attenuating Factors https://pubmed.ncbi.nlm.nih.gov/35524619/ Comorbid Major Depressive Disorder in Schizophrenia: A Systematic Review and Meta-Analysis https://pubmed.ncbi.nlm.nih.gov/33252130/ The RAISE Early Treatment Program for First-Episode Psychosis: Background, Rationale, and Study Design https://pubmed.ncbi.nlm.nih.gov/25830446/ First Episode Psychosis With and Without the Use of Cannabis and Synthetic Cannabinoids: Psychopathology, Global Functioning and Suicidal Ideation and Antipsychotic Effectiveness https://pubmed.ncbi.nlm.nih.gov/36682093/ Cannabis Use Among Patients With Psychotic Disorders https://pubmed.ncbi.nlm.nih.gov/35348056/ Methamphetamine Psychosis: Epidemiology and Management https://pubmed.ncbi.nlm.nih.gov/25373627/ Demographic and Clinical Correlates of Substance Use Disorders in First Episode Psychosis https://pubmed.ncbi.nlm.nih.gov/28697856/ Why Do Patients With Schizophrenia Smoke? https://pubmed.ncbi.nlm.nih.gov/20051860
Good sleep with little ones is a bit of a unicorn and seems like it will never happen but today's mini-episode gives you 6 tips on how to get better sleep and why it's so important. Sleep helps to repair and restore our body and brain and impacts our overall wellbeing. Poor sleep quality has been linked with instances of mental disorders like anxiety and depression. Joseph Dzierzewski PhD is Vice President of Research and Scientific Affairs at the National Sleep Foundation (NSF). Joe's previous position was as Associate Professor, Department of Psychology, at Virginia Commonwealth University, where he was a widely-published and well-funded investigator, and served as the Concentration Director for the Behavioral Medicine Program. He has also served on numerous Scientific Review Committees for both the American Academy of Sleep Medicine and National Institutes of Health, as well as serving as an Associate Editor for several academic journals. Joe's educational background is in Clinical Health Psychology, focusing on behavioral sleep medicine. Joe earned his doctoral degree from the University of Florida, completing advanced training in Behavioral Sleep Medicine, Geropsychology, and Methodology & Statistics. His grant-funded research program focused on the correlates and consequences of both normal and disordered sleep across diverse and underserved patient populations. Find out more at thensf.org Please like and subscribe to our podcast and leave a 5-star review so we can reach more parents like you! Subscribe to our podcast by sending an email to subscribe@teachingyourtoddler.com For more expert interviews, fun activities and story time podcasts, please visit our website at TeachingYourToddler.com Check us out on Facebook at Teaching Your Toddler and on twitter at @TeachingToddler and on Instagram at @teachingyourtoddler To support great future content, please click here and help us out with a $5 gift: glow.fm/teachingyourtoddler Leave us some feedback on this show and your ideas for future shows!
Judy is so excited to take you through part 1 of the behavioural and cognitive changes in AD episode (part 2 will be released as a bibliography). This shorter episode features standard motor symptoms like impaired exercise and grip strength, as well as some less studied behavioural changes such as adverse driving in AD. You don't want to miss this one! Sections in this episode: Behavioural Changes (3:30) Learning History (13:45) Depressive Symptoms (15:32) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file/d/1ETKdvpFtsh0Xw0TUM9_wII_aIx95VUxP/view?usp=share_linkTo access the folder with ALL our bibliographies, follow this link (it will be updated as we publish episodes and process bibliographies), or use the link below:https://drive.google.com/drive/folders/1bzSzkY9ZHzzY8Xhzt0HZfZhRG1Gq_Si-?usp=sharingYou can also find all of our bibliographies on our website: amindr.com. --------------------------------------------------------------Follow-up on social media for more updates!Twitter: @AMiNDR_podcastInstagram: @AMiNDR.podcastFacebook: AMiNDR Youtube: AMiNDR PodcastLinkedIn: AMiNDR PodcastEmail: amindrpodcast@gmail.com -------------------------------------------------------------- Please help us spread the word about AMiNDR to your friends, colleagues, and networks! And if you could leave us a rating and/or review on your streaming app of choice (Apple Podcasts, Spotify, or wherever you listen to the podcast), that would be greatly appreciated! It helps us a lot and we thank you in advance for leaving a review! Don't forget to subscribe to hear about new episodes as they come out too. Thank you to our sponsor, the Canadian Consortium of Neurodegeneration in Aging, or CCNA, for their financial support of this podcast. This helps us to stay on the air and bring you high quality episodes. You can find out more about the CCNA on their website: https://ccna-ccnv.ca/. Our team of volunteers works tirelessly each month to bring you every episode of AMiNDR. This episode was scripted and hosted by Judy Cheng, edited by Scott Prins, and reviewed by Ellen Koch and Anusha Kamesh. The bibliography was made by Anjana Rajendran and the wordcloud was created by Lara Onbasi (www.wordart.com). Big thanks to the sorting team for taking on the enormous task of sorting all of the Alzheimer's Disease papers into episodes each month. For November 2022, the sorters were Sarah Louadi, Eden Dubchak, Ben Cornish, Christy Yu, Dana Clausen, Kevin Nishimura, Anelya Gandy, Salodin Al-Achkar, Ellen Koch, and Elyn Rowe. Also, props to our management team, which includes Sarah Louadi, Ellen Koch, Naila Kuhlmann, Elyn Rowe, Anusha Kamesh, Lara Onbasi, Joseph Liang, and Judy Cheng, for keeping everything running smoothly.Our music is from "Journey of a Neurotransmitter" by musician and fellow neuroscientist Anusha Kamesh; you can find the original piece and her other music on soundcloud under Anusha Kamesh or on her YouTube channel, AKMusic. https://www.youtube.com/channel/UCMH7chrAdtCUZuGia16FR4w -------------------------------------------------------------- If you are interested in joining the team, send us your CV by email. We are specifically looking for help with sorting abstracts by topic, abstract summaries and hosting, audio editing, creating bibliographies, and outreach/marketing. However, if you are interested in helping in other ways, don't hesitate to apply anyways. --------------------------------------------------------------*About AMiNDR: * Learn more about this project and the team behind it by listening to our first episode: "Welcome to AMiNDR!"
In this episode, Donovan & Matt speak with Geoffrey Hoffman, a faculty member and researcher at the University of Michigan School of Nursing. Dr. Hoffman discusses the transition to the role of caregiver for partners of persons diagnosed with dementia – and the unique emotional burden and stress that they undertake. Dr. Hoffman also discusses using the Health & Retirement Study (HRS) to better explore the emotional stress and onset of depression in caregivers. Geoff Hoffman Faculty Profile: https://nursing.umich.edu/faculty-staff/faculty/geoffrey-j-hoffman Article Referenced in this Episode Harris ML, Errickson J, Ha J, Hoffman GJ. Depressive Symptoms and Caregiving Intensity Before and After Onset of Dementia in Partners: A Retrospective, Observational Study. Med Care. 2022;60(11):844-851. doi:10.1097/MLR.0000000000001771 [PMID: 36038513] The transcript for this episode can be found here.CAPRA Website: http://capra.med.umich.edu/ You can subscribe to Minding Memory on Apple Podcasts, Spotify, Google Podcasts or wherever you listen to podcasts. Hosted on Acast. See acast.com/privacy for more information.
Why are depressive symptoms poorly recognized and undertreated in African American women? Find out this and more in today's PVRoundup podcast.
Major depressive disorder affects 1 in 5 people in their lifetime worldwide. Many people don't know that your mood and mood disorders are inflammatory conditions and can be linked to your gut! Can we prevent chronic inflammation and thus, inflammatory conditions? What can we all do to help prevent or manage depressive symptoms when it comes to our food and lifestyle? What does sugar have to do with depression? The conversation around food quality is important when it comes to any health condition but food quantity and timing also play key roles. Let's dive in to some tips on how to make improvements to your nutrition to help with your depressive symptoms. In this episode we talk about: - Why finding the "root cause" of depression is a challenge. - What's the link between digestion and mood? - What is psychoneuroimmunology and how is that related to depression? - 5 key areas to focus on to help improve your depressive symptoms. Mentioned in this episode: - Schedule a free 20 minute consultation HERE! - The 14-day Sugar Experiment- click HERE to join! More fun stuff: - Healthy-ish for the Holidays guide- click HERE! - The ULTIMATE Smoothie Guide- CLICK HERE - Sugar Reset Mini Course- Click HERE - Connect on FACEBOOK or INSTAGRAM Do you like this podcast? Please make sure to leave a review wherever you listen to podcasts and share it with someone who would benefit from listening! Episode resources: Beurel, E., Toups, M., & Nemeroff, C. B. (2020). The Bidirectional Relationship of Depression and Inflammation: Double Trouble. Neuron, 107(2), 234–256. https://doi.org/10.1016/j.neuron.2020.06.002 Gujral, S., Aizenstein, H., Reynolds, C. F., 3rd, Butters, M. A., & Erickson, K. I. (2017). Exercise effects on depression: Possible neural mechanisms. General hospital psychiatry, 49, 2–10. https://doi.org/10.1016/j.genhosppsych.2017.04.012 López-López, J. A., Davies, S. R., Caldwell, D. M., Churchill, R., Peters, T. J., Tallon, D., Dawson, S., Wu, Q., Li, J., Taylor, A., Lewis, G., Kessler, D. S., Wiles, N., & Welton, N. J. (2019). The process and delivery of CBT for depression in adults: a systematic review and network meta-analysis. Psychological medicine, 49(12), 1937–1947. https://doi.org/10.1017/S003329171900120X Ménard, C., Hodes, G. E., & Russo, S. J. (2016). Pathogenesis of depression: Insights from human and rodent studies. Neuroscience, 321, 138–162. https://doi.org/10.1016/j.neuroscience.2015.05.053 Morssinkhof, M. W. L., van Wylick, D. W., Priester-Vink, S., van der Werf, Y. D., den Heijer, M., van den Heuvel, O. A., & Broekman, B. F. P. (2020). Associations between sex hormones, sleep problems and depression: A systematic review. Neuroscience and biobehavioral reviews, 118, 669–680. https://doi.org/10.1016/j.neubiorev.2020.08.006 Quirk, S. E., Williams, L. J., O'Neil, A., Pasco, J. A., Jacka, F. N., Housden, S., Berk, M., & Brennan, S. L. (2013). The association between diet quality, dietary patterns and depression in adults: a systematic review. BMC psychiatry, 13, 175. https://doi.org/10.1186/1471-244X-13-175
What is the relationship between gut microbiome and depressive symptoms?
What happened to Alex VanDalsen?Alex went missing on the night of February 3rd, 2021. After realizing he was gone, and not at his girlfriend's (which he normally was) mom called 911 on the 4th. It isn't until the 9th... let me repeat that, THE 9TH, that Alex is found, and Tippancoe County Sheriff's Department, and Lafayette Police Department in Indiana, acknowledge Jennifer's missing person report, and the death of an individual found almost 10 miles away from Jennifer's home.Alex's death was ruled as a suicide, but I implore you to dig deep, and ask yourself, "do I really think this is a suicide?"I don't, and I hope you don't either. Get mad, because I am fucking PISSED. Please consider signing Jennifer's petition Justice for Alex VanDalsenhttps://gofund.me/39a51342If you liked what you heard today, give me a review, and subscribe. I will love you for it, seriously.Follow me on Facebook, TikTok and Twitter @fthatpodInstagram @fthat_podSupport me on Patreon for more exclusive content @fthatpodAs always, thank you to F**k That's wonderful sources!Adams, S. H., Schaub, J. P., Nagata, J. M., Park, M. J., Brindis, C. D., & Irwin, C. E., Jr (2022). Young Adult Anxiety or Depressive Symptoms and Mental Health Service Utilization During the COVID-19 Pandemic. The Journal of adolescent health : official publication of the Society for Adolescent Medicine, 70(6), 985–988. https://doi.org/10.1016/j.jadohealth.2022.02.023Claridge, J. (n.d.) Entrance and exit wounds. https://www.exploreforensics.co.uk/entrance-and-exit-wounds.htmlDocuments obtained from Jennifer VanDalsen:Tippancoe County Incident Report 2021TC00580Including supplemental narratives 2, 3, 4, 5, 6, 7 Lafayette Police DepartmentIncident Report 47901Indiana Forensic & Surgical PathologyFinal Report Body Camera FootageOfficer Burton, Cooney, Daubenmier, Landis, Earnest
Certain intervention trials studying nutrition and depression have intentionally included recommendations to include animal protein. In turn, this leads to the question about the particular role of animal protein on mood. In particular, if there is an association between diets that exclude animal protein and depressive symptoms? In this podcast, I dive into a large cohort study that was looking at this question and discuss the interesting findings they (didn't) find around the vegan diet and what they did find around food exclusion as a variable. Matta, J., Czernichow, S., Kesse-Guyot, E., Hoertel, N., Limosin, F., Goldberg, M., … Lemogne, C. (2018). Depressive Symptoms and Vegetarian Diets: Results from the Constances Cohort. Nutrients, 10(11), 1695. https://doi.org/10.3390/nu10111695 Are you a practitioner and are you interested in Dr. Antonella's Mediterranean Diet Workshop? Registration is open now! Grab your spot here
What's the relationship between Cognitive function, physical activity, and depressive symptoms? Let's look at the latest research from the SHARE (Survey of Health, Ageing and Retirement) survey looking at 51K adults form over 25 countriesCsajbók, Z., Sieber, S., Cullati, S. et al. Physical activity partly mediates the association between cognitive function and depressive symptoms. Transl Psychiatry 12, 414 (2022). https://doi.org/10.1038/s41398-022-02191-7VISIT OUR STOREStore: https://www.selfelements.comFOLLOW USwww.selfprinciple.orgwww. youtube.com/selfprinciplewww.youtube.com/plantbasedkidneyhealthwww.instagram.com/seanhashmimd
Dr. May Beydoun from the Laboratory of Epidemiology and Population Sciences, NIA/NIH/IRP, in Baltimore, MD, discusses a research paper she co-authored that was published by Aging (Aging-US) as the cover for Volume 14, Issue 13, entitled, “Epigenetic clocks and their association with trajectories in perceived discrimination and depressive symptoms among US middle-aged and older adults.” DOI - https://doi.org/10.18632/aging.204150 Corresponding author - May A. Beydoun - baydounm@mail.nih.gov Video version - https://www.youtube.com/watch?v=gkiDhjTL0YY Abstract Background: Perceived discrimination may be associated with accelerated aging later in life, with depressive symptoms acting as potential mediator. Methods: A nationally representative sample of older adults was used [Health and Retirement Study 2010–2016, Age: 50–100 y in 2016, N = 2,806, 55.6% female, 82.3% Non-Hispanic White (NHW)] to evaluate associations of perceived discrimination measures [Experience of discrimination or EOD; and Reasons for Perceived discrimination or RPD) and depressive symptoms (DEP)] with 13 DNAm-based measures of epigenetic aging. Group-based trajectory and four-way mediation analyses were used. Results: Overall, and mostly among female and NHW participants, greater RPD in 2010–2012 had a significant adverse total effect on epigenetic aging [2016: DNAm GrimAge, DunedinPoAm38 (MPOA), Levine (PhenoAge) and Horvath 2], with 20–50% of this effect being explained by a pure indirect effect through DEP in 2014–2016. Among females, sustained elevated DEP (2010–2016) was associated with greater LIN DNAm age (β ± SE: +1.506 ± 0.559, p = 0.009, reduced model), patterns observed for elevated DEP (high vs. low) for GrimAge and MPOA DNAm markers. Overall and in White adults, the relationship of the Levine clock with perceived discrimination in general (both EOD and RPD) was mediated through elevated DEP. Conclusions: Sustained elevations in DEP and RPD were associated with select biological aging measures, consistently among women and White adults, with DEP acting as mediator in several RPD-EPICLOCK associations. Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.204150 Press release - https://www.aging-us.com/news_room/epigenetic-clocks-and-their-association-with-perceived-discrimination-and-depressive-symptoms Keywords - aging, DNA methylation, epigenetic clocks, biological age, perceived discrimination, depressive symptoms About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at https://www.Aging-US.com and connect with us: SoundCloud - https://soundcloud.com/Aging-Us Facebook - https://www.facebook.com/AgingUS/ Twitter - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/agingus LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM
Right now there are over 2 million people imprisoned across the United States, that represents a 500% increase over the last 40 years, and despite making up only 5% of the world's population, America accounts for more than 20% of the world's incarcerations. With prisons across the country, filling up and with most incarcerated individuals suffering from mental health conditions, many of them serious, understanding the impact of those illnesses, both inside and outside the prison walls, is increasingly important.
Research suggests that social media use may impact mental health in adults as well. Researchers found that social media platforms, including Facebook, Snapchat, and TikTok, were associated with an increased likelihood of depressive symptoms in adults who didn t initially report depression. The pandemic has changed the way we work, eat, shop, and use social media. The average American spent 65 minutes a day on social media in 2020, a nearly 20 percent increase from the year before, according to Statista, a market research company. The most preferred social media platform for COVID-19 updates was Facebook. Watch/Listen https://www.facebook.com/transformationtalkradio/live_videos/
Research suggests that social media use may impact mental health in adults as well. Researchers found that social media platforms, including Facebook, Snapchat, and TikTok, were associated with an increased likelihood of depressive symptoms in adults who didn t initially report depression. The pandemic has changed the way we work, eat, shop, and use social media. The average American spent 65 minutes a day on social media in 2020, a nearly 20 percent increase from the year before, according to Statista, a market research company. The most preferred social media platform for COVID-19 updates was Facebook. Watch/Listen https://www.facebook.com/transformationtalkradio/live_videos/
Listen to a press release about the cover paper of Volume 14, Issue 13, entitled, "Epigenetic clocks and their association with trajectories in perceived discrimination and depressive symptoms among US middle-aged and older adults.” ______________________________ A new research paper was published in Aging (Aging-US / Albany NY) on the cover of Volume 14, Issue 13, entitled, “Epigenetic clocks and their association with trajectories in perceived discrimination and depressive symptoms among US middle-aged and older adults.” “Perceived discrimination may be associated with accelerated aging later in life, with depressive symptoms acting as potential mediator.” In this recently published study, researchers May A. Beydoun, Hind A. Beydoun, Nicole Noren Hooten, Ana I. Maldonado, Jordan Weiss, Michele K. Evans, and Alan B. Zonderman from the National Institute on Aging's Intramural Research Program, Fort Belvoir Community Hospital, University of Maryland, and University of California Berkeley examined a nationally representative sample of 2,806 older U.S. adults. The team evaluated associations of perceived discrimination measures with 13 DNA methylation (DNAm)-based measures of epigenetic aging. They used group-based trajectory and four-way mediation analyses. “Here we examined retrospective data from the HRS [Health and Retirement Study 2010–2016] cohort study of U.S. adults aged 50–100 years and investigated measures of perceived discrimination and depressive symptoms in relation to 13 different DNAm-based epigenetic clocks (EPICLOCK) age-estimators.” Read the full press release - https://www.aging-us.com/news_room/epigenetic-clocks-and-their-association-with-perceived-discrimination-and-depressive-symptoms DOI - https://doi.org/10.18632/aging.204150 Corresponding Author: May A. Beydoun – Email: baydounm@mail.nih.gov Keywords: DNA methylation, epigenetic clocks, biological age, perceived discrimination, depressive symptoms Sign up for free Altmetric alerts about this article: https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.204150 About Aging-US: Launched in 2009, Aging (Aging-US / Albany NY) publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at www.Aging-US.com and connect with us: SoundCloud – https://soundcloud.com/Aging-Us Facebook – https://www.facebook.com/AgingUS/ Twitter – https://twitter.com/AgingJrnl Instagram – https://www.instagram.com/agingjrnl/ YouTube – https://www.youtube.com/agingus LinkedIn – https://www.linkedin.com/company/aging/ Pinterest – https://www.pinterest.com/AgingUS/ For media inquiries, please contact media@impactjournals.com. Aging Journal Office 6666 E. Quaker Str., Suite 1B Orchard Park, NY 14127 Phone: 1-800-922-0957, option 1
Morning mania is a program designed to provide a meal” in the morning for men on the move. With daily motivation, inspiration, and life coaching tips that seek to motivate, empower, and nurture a changed mindset, with men‘s life coach Rolando. To connect with your host for a one-on-one session and additional resources click the links. https://calendly.com/xyshyman/men-s-program-consultation-call (free consultation) https://amzn.to/3fj0q1p https://amzn.to/32O7Y9W https://amzn.to/3mTuWDy https://amzn.to/3KagnFG https://webinarkit.net/replay/61ad25b3f7e6b80016999cdc https://www.contactxyspark.com/service-page/masculinity-blueprint?referral=service_list_widget (men's program enrollment) https://xyspark.org/masculinity-blueprint/ (life coaching program link)
In this episode of The Counseling Psychologist podcast series, Editor Bryan Kim interviews Dr. Patrick Possel, the lead author of the TCP article “Migration Background, Gender, and the Prevention of Depressive Symptoms: A Secondary Analysis."
Madhukar Trivedi, MD, and Manish Jha, MD, MBBS, review the evidence on the efficacy of esketamine and ketamine as a treatment for major depressive disorder. Relevant disclosures can be found with the episode show notes on Medscape.com (https://www.medscape.com/viewarticle/968556). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Symptom Clusters as Predictors of Late Response to Antidepressant Treatment https://www.psychiatrist.com/jcp/depression/symptom-clusters-predictors-late-response-antidepressant/ Intranasal Esketamine https://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/SPRAVATO-pi.pdf Sequenced Treatment Alternatives to Relieve Depression (STAR*D) Study https://www.nimh.nih.gov/funding/clinical-research/practical/stard Clinical Results for Patients With Major Depressive Disorder in the Texas Medication Algorithm Project https://jamanetwork.com/journals/jamapsychiatry/fullarticle/482026 Efficacy and Safety of Olanzapine/Fluoxetine Combination vs Fluoxetine Monotherapy Following Successful Combination Therapy of Treatment-Resistant Major Depressive Disorder https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207330/ Esketamine Nasal Spray for Rapid Reduction of Depressive Symptoms in Patients With Major Depressive Disorder Who Have Active Suicide Ideation With Intent: Results of a Phase 3, Double-Blind, Randomized Study (ASPIRE II) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7816667/ Esketamine Nasal Spray for the Rapid Reduction of Depressive Symptoms in Major Depressive Disorder With Acute Suicidal Ideation or Behavior https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8407443/ Ketamine Versus Midazolam for Recurrence of Suicidality in Adolescents https://clinicaltrials.gov/ct2/show/NCT04592809 Youth Depression and Suicide Research Network (YDSRN) https://clinicaltrials.gov/ct2/show/NCT04572321 The Neurobiology of Depression, Ketamine and Rapid-Acting Antidepressants: Is it Glutamate Inhibition or Activation? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165688/ Effect of Ketamine on Limbic GABA and Glutamate: A Human In Vivo Multivoxel Magnetic Resonance Spectroscopy Study https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7507577/ Identifying Novel Mechanisms and Treatment Targets for Irritability and Aggression in Psychiatric Disorders https://www.nature.com/articles/s41386-021-01166-4 Ketamine Versus Midazolam for Recurrence of Suicidality in Adolescents https://clinicaltrials.gov/ct2/show/NCT04592809 Ketamine for Depression: An Update https://www.biologicalpsychiatryjournal.com/article/S0006-3223(16)32579-3/fulltext MDMA-Assisted Therapy for Severe PTSD: A Randomized, Double-Blind, Placebo-Controlled Phase 3 Study https://www.nature.com/articles/s41591-021-01336-3 Trial of Psilocybin versus Escitalopram for Depression https://www.nejm.org/doi/full/10.1056/NEJMoa2032994 The Clinical Pharmacology and Potential Therapeutic Applications of 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) https://onlinelibrary.wiley.com/doi/10.1111/jnc.15587
This episode is also available as a blog post: http://donnyferguson.com/2021/10/03/use-of-cbd-dominant-cannabis-products-associated-with-decreases-in-anxiety-and-depressive-symptoms/ --- Send in a voice message: https://anchor.fm/donny-ferguson/message
In this episode, I give tips on how to reduce the risk of depressive symptoms.Thank you so much for taking the time to listen to this podcast episode and stay tuned for tomorrow's! Our website: https://acupunctureismylife.com/ Follow our social media for more information on acupuncture: Instagram: https://www.instagram.com/acupunctureismylife/ Facebook: https://www.facebook.com/acupunctureismylifeTikTok: https://www.tiktok.com/@acupunctureismylife?lang=en
Individuals with major depressive disorder and suicidal ideation are particularly vulnerable and may not respond as well to standard treatment as patients without suicidal ideation. In this author podcast, Dr. Dong-Jing Fu and Dr. Carla Canuso discuss the results of a pooled analysis of data from the ASPIRE studies, randomized placebo-controlled trials of esketamine, plus comprehensive standard-of-care treatment. The results, published in the September-October 2021 issue of the Journal of Clinical Psychopharmacology, suggest that esketamine can provide rapid relief of depressive symptoms in patients with MDD and acute suicidal ideation or behavior, especially in those with a history of prior suicide attempt.
The hosts for this episode are psychology undergraduate students, Kiara White and Mckenzie Schwartz, interning at Advanced Therapeutic Solutions for Anxiety. Here, they interview Samantha and Jackie about their experiences in graduate school. Samantha Addante is a 5th-year Ph.D. Doctoral Clinical Psychology student at Oklahoma State University and Jackie Pabis is a 5th-year Ph.D. Clinical Psychology student at Northern Illinois University. We wanted to include some links below to some of the publications from both Samantha and Jackie that we discussed, links to graduate programs from both colleges and a link to the ATSA website: Samantha Addante: Family-Centered Care Approaches for Neonatal Abstinence Syndrome: Caring for Mothers and Infants - https://www.researchgate.net/publication/348683996_Family-Centered_Care_Approaches_for_Neonatal_Abstinence_Syndrome_Caring_for_Mothers_and_Infants Stigma Moderates the Relation Between Peer Victimization, Thwarted Belongingness, and Depressive Symptoms in Youth with Inflammatory Bowel Disease - https://www.researchgate.net/publication/350961738_Stigma_Moderates_the_Relation_Between_Peer_Victimization_Thwarted_Belongingness_and_Depressive_Symptoms_in_Youth_with_Inflammatory_Bowel_Disease Oklahoma State University Clinical Psychology Ph.D. Program - https://go.okstate.edu/graduate-academics/programs/doctoral/psychology-option-in-clinical-phd.html Jacqueline Pabis: Parent–Adolescent Communication Influences on Anxious and Depressive Symptoms in Early Adolescence - https://www.researchgate.net/publication/341583580_Parent-Adolescent_Communication_Influences_on_Anxious_and_Depressive_Symptoms_in_Early_Adolescence Coping Strategies and Psychological Symptoms Among Children on St. Thomas in the Aftermath of Hurricanes Irma and Maria: Coping and Psychological Symptoms Among Children - https://www.researchgate.net/publication/337751410_Coping_Strategies_and_Psychological_Symptoms_Among_Children_on_St_Thomas_in_the_Aftermath_of_Hurricanes_Irma_and_Maria_Coping_and_Psychological_Symptoms_Among_Children Northern Illinois University Clinical Psychology Ph.D. Program - https://www.niu.edu/clas/psychology/academics/graduate/clinical/index.shtml ATSA Website: https://www.advancedtherapeuticsolutions.org/
Removal of both ovaries in a premenopausal woman results in an abrupt withdrawal of estrogen, progesterone, and testosterone. Therefore removing your ovaries may have significant effects on your mood and well-being. Join Sarah and Beth as they hear from a fellow young survivor also named Sarah as she shares her experience with having her uterus and ovaries removed after a breast cancer diagnosis.
Episode 5! Can't believe we've been doing this for an entire month! In this episode I get into some social media statistics and why everyone should take a step back and truly look at their social media usage. I'll be the first to say that I'm not perfect who it comes to limiting the time I spend on Instagram, but when I do I feel so much better. Just wanted to supply you all with some practical tips on this and bring it to light! Enjoy!-Winnie Timestamps 1:02 Go to Bible Camp5:56 Screen Time Statistics7:30 Link Between Screen Time and Depressive Symptoms 9:08 Superficial vs. Genuine Connections 11:40 Why do we need to be distracted? 14:30 I'm Guilty too 15:35 Breaking a Habit 16:06 My Challenge to You17:25 Bible Verse
In this episode I discuss how food can create our moods and what specific foods you can take away & add in to your diet to create less anxious & depressive symptoms & create a more steady mood. --- Support this podcast: https://anchor.fm/heather1422/support
FDA 连续批准2个单抗治疗视神经脊髓炎JAMA 服用维生素D3或阿斯匹林均不能降低抑郁症的风险Nature Neuroscience 夜间光照诱导的类抑郁行为在《神经科星期四 Episode 24》中，和大家介绍了抗补体蛋白C5单克隆抗体依库珠单抗（eculizumab），2019年6月被批准用于治疗水通道蛋白阳性的神经脊髓炎谱系障碍。2020年，又有两个新型的单克隆抗体上市用于治疗视神经脊髓炎。简单回顾一下：视神经脊髓炎谱系障碍（Neuromyelitis Optica Spectrum Disorder，NMOSD）是一种复发性自身免疫性炎症性疾病，通常影响视神经和脊髓。至少三分之二的病例水通道蛋白-4抗体（AQP4-IgG）和补体介导的中枢神经系统损伤有关。沙利珠单抗（satralizumab）沙丽珠单抗（satralizumab）是抗IL-6受体的单克隆抗体，当联用免疫抑制剂治疗时，可降低视神经脊髓炎谱系障碍患者复发的风险。2020年8月，沙利珠单抗被FDA批准用于治疗水通道蛋白-4抗体阳性的、视神经脊髓炎患者。《随机双盲对照研究：沙利珠单抗单药治疗视神经脊髓炎的安全性和有效性的3期试验》Lancet Neurology，2020年5月 (1)这项研究评估了沙丽珠单抗单药治疗视神经脊髓炎患者的安全性和有效性。在这个III期、双盲、安慰剂对照、平行组试验中，纳入了水通道蛋白-4抗体阳性或阴性的成年患者，参与者被随机分配（2:1）在第0、2、4周接受沙丽珠单抗120mg皮下注射或安慰剂，此后每4周接受一次注射。同时停止服用免疫抑制剂。共纳入168名参与者，随访期间，30%治疗组患者和50%对照组患者出现复发。两组间严重不良事件和导致停药的不良事件发生率相似。结论：与安慰剂相比，沙丽珠单抗单药治疗降低了视神经脊髓炎的复发率，具有良好的安全性。英必珠单抗（inebilizumab）英必珠单抗是CD19单克隆抗体，本研究旨在研究CD19单抗在降低视神经脊髓炎中的有效性和安全性。2020年6月，FDA已批准英必珠单抗上市，用于治疗视神经脊髓炎。《N-MOmentum研究：英必珠单抗治疗视神经脊髓炎谱系障碍的2/3期试验》Lancet，2019年10月 (2)这是一项多中心、双盲、随机安慰剂对照2/3期研究。参与者被随机分配到300mg 英必珠单抗或安慰剂组，在第1天和第15天接受用药。共招募230名参与者治疗组中12%的患者随访期间复查，安慰剂组39%出现复发（p < 0·0001）。治疗组中72%的患者和安慰剂组73%的患者出现不良反应。结论：与安慰剂相比，英必珠单抗降低了视神经脊髓炎的复发的风险，具有潜在的应用价值。出血性脑卒中出血性脑卒中一般来源于微动脉或小动脉，出血直接进入脑组织，形成局限性血肿。最常见的原因包括：高血压、脑外伤、全身出血倾向、淀粉样脑血管病及血管畸形。不常见的原因包括：肿瘤内出血、动脉瘤破裂及血管炎。《ARUBA研究：未破裂脑动静脉畸形的介入治疗与单独药物治疗的试验的最终随访》Lancet Neurology，2020年7月(3)是一项多国、多中心的随机试验，旨在评估被诊断为未破裂脑动静脉畸形的成年患者中，病变经过评估适合通过介入手术可以根除病变的情况下，介入治疗还是单独药物治疗效果更好。在预先指定的中期分析：显示在预防症状性卒中或死亡方面，单独药物治疗优于药物治疗和介入治疗的联合治疗组，在平均33·3个月的随访中停止了随机化。研究继续随访平均50.4个月后，单纯药物治疗组的死亡或症状性卒中发生率（3.39/每100人年）低于介入治疗的患者（12·32/100人年）。药物治疗组2例，介入治疗组4例死亡。与介入治疗相比，分配到药物治疗的患者的不良事件较少。结论：经过长期的随访，ARUBA显示在预防未破裂的脑动静脉畸形患者的死亡或症状性卒中方面，单纯的医疗管理仍优于介入治疗。《评论：未破裂的脑动静脉畸形的治疗策略》Lancet Neurology，2020年7月 (4)动静脉畸形是青壮年脑出血的主要原因。当它还没有引起癫痫、局灶性神经缺损的时候，有时偶然在影像学检查中被发现，在这些未破裂的病例中，通过介入治疗栓塞或切除动静脉畸形以及相关动脉瘤，可能可以降低颅内出血的长期风险，但是在随机试验中缺乏风险和收益平衡的证据。《随机对照研究：院外氨甲环酸治疗对中重度外伤性脑损伤患者神经功能预后的影响》JAMA，2020年9月 (5)研究的目的是评估中重度外伤性脑损伤2小时内，院外予氨甲环酸治疗对神经学结果的影响。研究纳入年龄≥15岁、Glasgow昏迷评分19mmHg与死亡率相关，而颅内压
Depression management interventions need to be individualized to address: ~ Acute crisis and dangerousness ~ Biomedical conditions and complications ~ Emotional, behavioral or cognitive issues ~ Readiness for change for EACH issue/objective ~ Strengths for addressing each issue ~ Relapse or continued problem potential ~ Stage of readiness for change ~ Recovery environment Learn more about your ad choices. Visit megaphone.fm/adchoices
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