Healthspan

https://www.nejm.org/doi/full/10.1056/NEJMoa2204233

SURMOUNT 1 Trial. The aim of this trial was to investigate the safety and efficacy of Tirzepatide, a novel GLP + GIP in people with obesity. We discuss the trial in this episode.

@ michaelsalzle Patients with diabetes and chronic disease are at high risk for kidney failure, cardiovascular events, and death. The FLOW trial looked at the safety and efficacy of semaglutide in patients with chronic disease and type 2 diabetes.

@michaelsalzlePreservation of your immune system, mind, and muscle

@michaelsalzle In this episode, we learn how to preserve our bones, bowel, circulation, hair, hearing, and hormones.

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@michaelsalzle. In this episode, we discussed pathways of aging. We discuss the importance of genes, AMPK, autophagy, metformin, foods that boost AMPK, autophagy, foods that boost autophagy, spermidine,epigenetics, and cellular senescence

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@michaelsalzle. In this episode we discuss nutrition 3.0. Epidemiology, clinical trials. The Mediterranean diet, the University of Wisconsin CR trial vs the NIH CR trial, carbohydrates, and protein.

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IG: @michaelsalzle. In this episode, we go into the broad topic of exercise. Exercise is considered the most powerful longevity drug. We review studies that underscore the importance of exercise. We also discuss the centenarian decathlon, and take a deep dive into zone 2 training.

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@michaelsalzle. The Long Game

https://www.pnas.org/doi/10.1073/pnas.1716173114 @michaelsalzle

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@michaelsalzle Metformin and it's effect on the hallmarks of aging https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8965502/#abstract-1title

@michaelsalzle. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8965502/#abstract-1title

@michaelsalzle. In this episode, learn about how to keep your muscle and blood young, circadian rhythm, bifidobacterium, butyrate, akkermansia, and keeping a strong gut lining. --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app

@michaelsalzle --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app

@michaelsalzle. https://www.cell.com/cell/fulltext/S0092-8674(22)01570-7 a link to David Sinclair's new paper I referenced in this episode --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app

@michaelsalzle in this episode I discuss the best supplements for athletic performance, the different types of protein, creatine, inositol, Amino Acids, caffeine, etc. --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app

@michaelsalzle. Learn more about obesity, weight loss, hormones, calories in vs. calories out, importance of protein in muscle sparing, and metabolic rates

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@michaelsalzle. Hot and cold protocols for improving performance, recovery, and overall health. Using glaborous skin to your advantage and the role of AVA‘s, the benefits of pre-exercise cooling, negative effects of cold exposure on exercise performance and adaptation, and heat exposure/heat shock proteins for improving performance and our health.

@michaelsalzle. Exercise, sleep, and future innovations in the field of aging (CR mimetics, senolytics, young blood, and yamamaka factors)

@michaelsalzle. IGF, protein restriction, FMD, TRE, 5:2 and ADF

@michaelsalzle. The benefits of calorie restriction and slowing our biological age

@michaelsalzle. Ways to measure your biological age

@michaelsalzle. Biological age vs. chronological age, and the importance of making aging a disease. She also reviews the different hallmarks of aging

@michaelsalzle supplements to lower uric acid, CGM importance, and the importance of time restricted eating.

@michaelsalzle. Uric Acid and the link with Alzheimer's disease, sleep and uric acid, and other instigators of elevated uric acid

@michaelsalzle. Uric Acid- what it is, where it comes from, and how its implicated in many diseases including HTN, diabetes, NAFLD, Alzheimer's, and much more.

@michaelsalzle Diabetes, Obesity, and Alzheimer's therapeutics

@michaelsalzle Peptide, Key nutraceuticals like Metformin and NAD, hormones, fasting, time restricted eating, and the healing powers of hot and cold

@michaelsalzle. AI diagnostics, anti aging, CAR T cell therapy, CRISPR, and the WNT signaling pathway

@michaelsalzle. Introductory episode. Why Tony Robbins is writing a book about regenerative technology, diagnostic breakthroughs, and anti aging. I also discuss the power of stem cells.

@michaelsalzle. Sleep disorders, alcohol and sleep, temperature and sleep, the dark side of sleeping pills, and sleep in healthcare

@michaelsalzle. Dreaming, Freud, the purpose of dreaming, nghtmres, ptsd, and dreaming for creativity

@michaelsalzle. Sleep for learning and memory. And sleep and it's association with Alzheimer's, CVD, and Cancer

@michaelsalzle. The four differences in sleep across species, sleep before birth, sleep and its possible association with ASD, childhood sleep, and sleep in midlife and old age and why it decreases so substantially

@michaelsalzle. In this episode, I cover What sleep is, what sleep isn't, caffeine, melatonin, sleep pressure, the sleep cycle, defining and generating sleep, NREM and REM

@michaelsalzle. GST, NOS3, and PEMT