Podcasts about telomeres

Molecular biologist, gerontologist and Ultra Marathoner, Dr. Bill Andrews, a pioneer in telomere and telomerase research, sits down with Kelly and makes the case that telomere shortening is the most important clock driving human aging for healthy people and that real “rejuvenation” has to show up in function, not just numbers on a lab report. His blunt standard is the “Betty White test”: can you clearly tell which version of someone is younger by how they look, feel, and behave? From there, we get practical for masters swimmers and endurance athletes. Bill breaks down the tug of war between telomere shortening and lengthening, why inflammation and oxidative stress speed up biological aging, and how training falls into a Goldilocks zone. Consistent movement can build immune tolerance, while sporadic extreme efforts can trigger unnecessary inflammation. We also cover stress reduction through yoga and meditation, and why tapering is a secret weapon for performance and recovery. We also take on the risky side of the longevity marketplace: misleading telomere tests in blood, “anti-aging” tactics that can increase cell turnover, and the hype cycle around peptides, stem cells, and exosomes. Bill explains how he evaluates evidence with critical meta-analysis, shares what he's seen from telomerase-activating ingredients, and points to tools like the ALCAT food sensitivity test and biological age testing to guide smarter choices. • telomeres as chromosome end caps and why they shorten with each cell division• telomerase as the enzyme that can rebuild telomeres and the “tug of war” model• inflammation and oxidative stress as drivers of accelerated aging• endurance exercise as a Goldilocks effect plus the value of consistency and tapering• evolution's case for aging and why Bill wants to outsmart it for individuals• Telovital as an example of telomerase activation plus limits of anecdotal results• why average telomere length in blood can rise without true telomere lengthening• how cosmetic resurfacing immune stimulation and some growth signals can backfire• peptides stem cells and exosomes through the lens of critical meta-analysis• practical steps like yoga meditation optimism anti-inflammatory diet and the ALCAT test.For more information on Dr. Bill Andrews https://sierrasci.com/If you care about lifespan, healthspan, and staying fast in the water as you get longer lived, subscribe, share this with a training partner, and leave a review so more athletes can find the show.Email us at HELLO@ChampionsMojo.com. Opinions discussed are not medical advice, please seek a medical professional for your own health concerns.You can learn more about the Host and Founder of Champions Mojo at www.KellyPalace.com

How does bipolar disorder actually accelerate aging? And what can you start doing today to slow the aging process down?Psychiatrist and researcher Dr. Paula Villela Nunes explores the rarely discussed science behind bipolar disorder and accelerated aging, including the role of stress, inflammation, lifestyle, cardiovascular health, telomeres, and increased risk for dementia. She breaks down the hopeful side of the research on how you can take to protect long-term brain health.(0:00) Does Bipolar Disorder Make You Age Faster?(0:38) Genetics vs Lifestyle Stress(1:08) The Science of Telomeres(2:09) How to Slow Bipolar Aging(2:47) Do Bipolar Medications Speed Up Aging?(3:18) Dementia & LithiumRelevant readings:"Telomere Length and Bipolar Disorder" study (2017): https://nature.com/articles/npp2017125''Does bipolar disorder accelerate cellular aging?" meta-analysis of telomere length (2025): https://pubmed.ncbi.nlm.nih.gov/40803151"ISBD Guide for Older Adults with Bipolar Disorder" (2022): https://www.isbd.org/Files/Admin/Task...Bipolar Explained is a new #talkBD series spotlighting expert perspectives on the history, biology, and management of bipolar disorder.Dr. Paula Villela Nunes is a psychiatrist, psychotherapist, and researcher whose work focuses on bipolar disorder, aging, and mental health care across the lifespan. Originally from Brazil, she earned her MD and PhD from the University of São Paulo and has worked clinically and academically in both Brazil and Canada. She is currently based in Vancouver, where she works as a researcher at the University of British Columbia.Dr. Nunes has a special interest in aging and bipolar disorder, cognitive health, psychotherapy, and non-pharmacological approaches to recovery and wellness. She is a member of the International Society for Bipolar Disorders (ISBD) and serves as chair of the ISBD Older Age Bipolar Disorder Task Force . Her work also explores the role of families and care partners in supporting people living with bipolar disorder, alongside broader efforts to improve mental health awareness and reduce stigma in the community.

Reviewing a portion of the Darkhorse Podcast, ” Is Cell Phone Radiation Good For You? The 317th Evolutionary Lens w/ Bret Weinstein & Heather Heying”

In this episode of the Gladden Longevity Podcast, Jeff Gladden and Jason Sonners delve into the fascinating world of hyperbaric therapy. Jason shares his personal journey from experiencing a debilitating disc injury to discovering the profound benefits of hyperbaric oxygen therapy. They explore the science behind oxygen's role in cellular function, the therapeutic effects of hypoxia, and the importance of balancing various longevity strategies. The conversation also touches on recent studies regarding telomere length and the potential of hyperbaric therapy to promote cellular health. Finally, they discuss the risks associated with hyperbaric therapy and the importance of gradual exposure to maximize benefits.   For Audience Join the other 20,000+ high-performers getting weekly insights on biological reversal, exponential strategies, and Life Energy optimization→ https://start.gladdenlongevity.com/subscribe If you're ready to measure your 60+ biological ages and build a personalized reversal plan, apply for a discovery call here → https://start.gladdenlongevity.com/apply-now   Use code 'Podcast10' to get 10% OFF on any of our supplements at https://gladdenlongevityshop.com/!      Takeaways ·       Jason's journey into hyperbaric therapy began with a personal injury. ·       Hyperbaric therapy can significantly improve oxygen delivery to tissues. ·       Pressure increases the body's ability to carry oxygen beyond red blood cells. ·       Hypoxia can trigger beneficial healing pathways in the body. ·       Balancing various health strategies is crucial for sustainable longevity. ·       Recent studies show hyperbaric therapy may increase telomere length. ·       Gradual exposure to hyperbaric therapy can enhance its benefits. ·       Understanding the risks of hyperbaric therapy is essential for safety. ·       Hormetic stress can lead to improved health outcomes. ·       Biology thrives on balance and variety in health practices. Oxygen toxicity can occur with excessive exposure to oxygen. ·       Hyperbaric therapy sessions are typically shorter than ICU oxygen treatments. ·       Balancing oxygen levels is crucial for effective therapy. ·       The minimum effective dose is essential for maximizing benefits. ·       Glymphatic drainage is important for brain detoxification. ·       Hyperbaric therapy can be used preventatively for neurological disorders. ·       Wound healing can be enhanced with hyperbaric therapy pre and post-surgery. ·       Combining therapies can lead to better outcomes. ·       Regulatory challenges exist in the growing field of hyperbaric medicine. ·       Education and training are vital for safe practice in hyperbaric therapy.   Chapters 00:00 Introduction to Hyperbaric Therapy 03:02 Personal Journey and Discovery of Hyperbaric Therapy 06:06 Understanding the Science of Oxygen and Pressure 08:55 The Role of Hypoxia and Hormesis in Healing 11:54 Balancing Longevity Strategies 15:08 Telomeres and Longevity: Insights from Recent Studies 18:10 The Importance of Gradual Exposure in Hyperbaric Therapy 21:09 Risks and Considerations in Hyperbaric Therapy 23:07 Understanding Oxygen Toxicity 26:53 Balancing Oxygen Levels for Optimal Health 31:29 The Minimum Effective Dose in Therapy 33:43 Glymphatic Drainage and Brain Health 35:40 Hyperbaric Therapy in Wound Healing 40:49 Future of Hyperbaric Medicine and Regulation   To learn more about Dr. Jason Sonners: Website: https://hbotusa.com/ Instagram: https://www.instagram.com/hbotusa   Reach out to us at:    Website: https://gladdenlongevity.com/     Facebook: https://www.facebook.com/Gladdenlongevity/    Instagram: https://www.instagram.com/gladdenlongevity/?hl=en     LinkedIn: https://www.linkedin.com/company/gladdenlongevity    YouTube: https://www.youtube.com/channel/UC5_q8nexY4K5ilgFnKm7naw     Gladden Longevity Podcast Disclosures Production & Independence The Gladden Longevity Podcast and Age Hackers are produced by Gladden Longevity Podcast, which operates independently from Dr. Jeffrey Gladden's clinical practice and research at Gladden Longevity in Irving, Texas. Dr. Gladden may serve as a founder, advisor, or investor in select health, wellness, or longevity-related ventures. These may occasionally be referenced in podcast discussions when relevant to educational topics. Any such mentions are for informational purposes only and do not constitute endorsements. Medical Disclaimer The Gladden Longevity Podcast is intended for educational and informational purposes only. It does not constitute the practice of medicine, nursing, or other professional healthcare services — including the giving of medical advice — and no doctor–patient relationship is formed through this podcast or its associated content. The information shared on this podcast, including opinions, research discussions, and referenced materials, is not intended to replace or serve as a substitute for professional medical advice, diagnosis, or treatment. Listeners should not disregard or delay seeking medical advice for any condition they may have. Always seek the guidance of a qualified healthcare professional regarding any questions or concerns about your health, medical conditions, or treatment options. Use of information from this podcast and any linked materials is at the listener's own risk. Podcast Guest Disclosures Guests on the Gladden Longevity Podcast may hold financial interests, advisory roles, or ownership stakes in companies, products, or services discussed during their appearance. The views expressed by guests are their own and do not necessarily reflect the opinions or positions of Gladden Longevity, Dr. Jeffrey Gladden, or the production team. Sponsorships & Affiliate Disclosures To support the creation of high-quality educational content, the Gladden Longevity Podcast may include paid sponsorships or affiliate partnerships. Any such partnerships will be clearly identified during episodes or noted in the accompanying show notes. We may receive compensation through affiliate links or sponsorship agreements when products or services are mentioned on the show. However, these partnerships do not influence the opinions, recommendations, or clinical integrity of the information presented. Additional Note on Content Integrity All content is carefully curated to align with our mission of promoting science-based, ethical, and responsible approaches to health, wellness, and longevity. We strive to maintain the highest standards of transparency and educational value in all our communications.  

The crew is back as we get closer and closer to Episode 400! We kick things off with some hilarious outfit roasting before getting sidetracked by an impromptu push-up challenge debate. Then, we dive right into the music: We give our raw recap of the Tank vs. Tyrese Verzuz battle, explaining why Tank's performance and pen game completely stole the show. We debate whether Jamie Foxx gets enough credit as an R&B artist, if R&B inherently makes for a better Verzuz format than Hip-Hop (shoutout to The LOX vs. Dipset), and who would win a pop-star Verzuz between Britney Spears and Miley Cyrus. We also cover the latest Houston news, including the wild TSA delays at the airport that have led to hilarious cheating rumors about people being "stuck" in the city, plus Lil Flip's tease about the legendary Houston Comets WNBA franchise making a comeback. Finally, we end with some deep late-night texting etiquette, OnlyFans jokes, and wild conspiracy theories about telomeres and aliens! Follow the crew: @ThePourHorsemen @ShyThugg | @HardbodyKiotti | @Phi1TheDon | @LebronaldPalmer I @yo.dj.silk I @armourie.official Production Crew @TheJohnSims | @1Kharyy Shot at @TheHiveHouston Hurt At Work? Contact our partners at https://crockett.law for all of your legal needs. @bankonbriantx is ready to help. Join our Patreon for more exclusive content: https://www.patreon.com/thepourhorsemen By supporting us, you're not just a listener but a valued part of our community. Use our Code POUR at Bluechew.com for your discount. Follow The Pour Horsemen on Instagram @thepourhorsemen and email at thepourhorsemen@gmail.com. Chapters: 00:00 - Intro: 05:35 - Verzuz Recap 12:08 - Does R&B Make the Best Verzuz? 16:58 - Pop Verzuz Debate 19:35 - The "Stuck in Houston" Cheating Rumors 28:31 - WNBA Talk: Are the Houston Comets Finally Coming Back? 33:07 - Booty Call Etiquette & Why "What Are You Doing?" Texts Are Annoying 38:20 - Side Hustles, OnlyFans Banter & Spider-Man Costumes 49:18 - Conspiracy Theories: Billy Carson, Telomeres & Alien Prisoners

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If you want to get leaner and live longer check out https://milliondollarbodylabs.com   Have you ever wondered if you could actually reverse the aging process and optimize your biology to thrive for the next hundred years? I compiled talks from my archives about biohacking and longevity. Sean McCormick explains how psychedelics and ketamine clinics help brain health through neuroplasticity. Dr. Joy Kong discusses using stem cells from birth tissue to fix inflammation and repair tissue. Dr. Bill Andrews describes telomeres as caps on DNA and explores turning on telomerase to stop aging. Jon Sabes shares how lifestyle and thoughts drive gene expression. Hunter Ziesing talks about healthcare using AI for diagnostics and reminders. These experts provide strategies to help people manage health and increase lifespan.   Key Takeaways Psychedelics as Accelerators: Substances like ketamine can act as a "dissociative" to help people distance themselves from negative self-perceptions and process trauma. The Power of Stem Cells: Stem cell therapy can fix illness at a fundamental level by reducing inflammation, breaking down scar tissue, and improving mitochondrial function. Telomeres and Aging: Telomeres are like the caps on shoelaces; they protect DNA but shorten as cells divide. Inducing telomerase may help reach the "dimmer switches" that control aging. Epigenetic Clocks: Your biological age can be decoupled from your chronological age through lifestyle choices, as measured by DNA methylation patterns on the Horvath clock. AI Diagnostics: Future healthcare will likely involve "driverless doctors" and AI agents that provide a "check engine light" for your body through continuous data monitoring and reminders. "Goldilocks" Exercise: Consistent endurance exercise that stays "fun" helps minimize the inflammatory response that otherwise accelerates telomere shortening.   Resources Nate Palmer: The founder of The Million Dollar Body and author of "The Million Dollar Body Method", Nate has been coaching for over 15 years and has worked personally with over 1,000 clients. Website: https://milliondollarbodylabs.com Book: The Million Dollar Body Method Lean Energy Stack: https://milliondollarbodylabs.com/pages/lean Instagram: @_milliondollarbody

Dr. Elaine Chin is trying to solve the problem of people aging into chronic inflammation, fatigue, and disease because they are surrounded by confusing wellness advice and are guessing instead of using a science-based, personalized approach to healthspan. In this episode, she frames the answer as precision medicine built on measurable biology and consistent daily habits.In today's conversation Elaine Chin explores how precision medicine and lifestyle medicine can work together to improve healthspan and lifespan. She and Dr. Wells discuss telomeres, inflammation, Mediterranean-style eating, hydration, movement, recovery, and the role of purpose in healthy aging. The conversation stays grounded in practical decisions people can make every day while also emphasizing the value of understanding biomarkers and hormones. Overall, this episode helps listeners cut through health misinformation and return to a more evidence-informed foundation for wellbeing.You will learn how Dr. Chin thinks about lifestyle medicine as an “orchestra” that requires sleep, nutrition, movement, mindfulness, and social wellbeing to work together. You will also hear her explain why she pays close attention to telomeres, chronic inflammation, hydration, ultra-processed foods, omega-3 fats, and biomarker testing. The episode also clarifies the difference between exercise and general activity, and why small daily habits can shape long-term health more than extreme interventions.You will discover that many of the most powerful longevity tools are still the fundamentals: sleep, purpose, movement, hydration, and food quality. Dr. Chin's core insight is that these are not just “healthy habits”; they are biological signals that shape inflammation, recovery, and the pace of aging.This episode helps solve the challenge of not knowing where to start with health and longevity when the wellness space feels noisy, extreme, and contradictory. Dr. Chin brings the listener back to a simpler model: understand your biology, focus on the basics, and use data to guide smarter decisions.Key take aways:Lifestyle medicine works best in combination.Telomeres reflect the wear of aging.Ultra-processed foods drive inflammation.Movement all day matters.Know your biology before guessing.

Dr. Michael Greger, physician, bestselling author of How Not to Die and How Not to Age, and founder of NutritionFacts.org, joins the Visible Voices Podcast to share why what we eat is the single most important decision we make for our health. Drawing on decades of research and over 13,000 scientific citations, Dr. Greger breaks down how a whole food, plant-based diet can prevent, arrest, and even reverse chronic disease, slow the visible signs of aging, reduce systemic inflammation, and add years — even decades — to your life. 00:00 Introduction and Background 03:19 The Transformational Power of Lifestyle Medicine 06:23 Skin Health and the Importance of Sun Protection 10:58 Addressing Social Determinants of Health 14:27 Telomeres and Aging: Can We Reverse the Clock? 23:16 OuttroVVP.mp3 23:53 NEWCHAPTER 23:58 NEWCHAPTER_2 Wish to help the show? Click

Dr Deb Muth 00:03Well, welcome back to Let’s Talk Wellness Now. I am your host, Dr. Deb. And what is the most talked-about peptides in functional medicine? aren’t actually FDA approved. Not because they don’t work, but because no one’s funded the research to prove it yet. The truth is, some of the compounds that dominate wellness forums, BPC-157, TB-500, thymosin beta-4, epitalin, occupy a fascinating space between breakthrough science and unregulated experimentation. In today’s episode, we’re stepping into that grey zone, the world of investigational peptides, to separate mechanism from marketing. I’m going to walk you through the science that actually shows and where it stops, how to evaluate claims when human data don’t yet exist, and the quality, purity, and safety red flags that you need to recognise. Dr Deb Muth 01:06I created it in a previous episode, so go check that one out. And why honesty is the most important prescription in peptide medicine. If you’ve ever wondered whether these research-only peptides are the frontier of healing or the next functional medicine fad, this episode is for you. So grab your cup of tea or coffee, get comfortable, and let’s talk about what it really means to use peptides that are promising but still under investigation. So we’re going to break just for a second here and have a word from our sponsor. It is because of them that we stay on the air. So thank you for this. And we will be right back. Did you know sweating can literally heal your cells? Infrared saunas don’t just relax you. They detox your body, balance hormones, and boost mitochondrial energy. I’m obsessed with my Health Tech sauna. And right now, you can save $500 with my code at healthtechhealth.com slash dr-muth-req-25. Dr. Deb Muth 02:15All right, guys, welcome back. Let’s dive into investigational peptides, the evidence gap. So the following peptides we’re about ready to discuss are extensively in integrative, functional, and regenerative medicine circles. They may have intriguing mechanisms and promising preclinical data. However, they lack FDA approval, and the evidence quality varies dramatically. from interesting preliminary research to essentially no human data at all. And this distinction is really critical for maintaining scientific integrity. So let’s talk about immune-modulating peptides. There’s thymus and alpha-1, and this is an international story on the thymic peptides. Thymusin alpha-1, known as TA1, is marketed internationally as zidaxin. Dr. Deb Muth 03:16It’s a 28-amino acid polypeptide originally isolated from thymusin fraction 5, which was extracted from bovine thymus tissue. Modern production uses synthetic peptide synthesis. The thymus gland is located behind the sternum and is the primary site for T cell maturation, and thymic peptides like TA1 play roles in human system development and regulation. Now, I love thymus peptides. I love thymus glandular products. I’ve used thymus glandular products for decades. Ground-up animal thymus gland is basically what it is. There are a couple of different supplement companies that I’ve used over the years that are amazing with this. And they do a fantastic job, and they really do help to support the immune system. So when thymus peptides came out, it was really exciting because it took the whole idea of thymus support to a new level. Dr. Deb Muth 04:17The mechanism actually behind the thymus in alpha-1 is complex and involves multiple aspects of immune function. At the cellular level, TA1 enhances T cell maturation and differentiation, particularly the development of helper T cells and cytotoxic T cells. It modulates T cell receptor expression and can influence the balance between Th1 cell-mediated immunity and Th2 humoral immunity responses. And it also enhances the natural killer cell activity and modulates dendritic cell function, which are critical for antigen presentation. and initiation of adaptive immune responses. And on the cytokine level, TA1 influences production of interleukin-2, IL-2, interferon gamma, IFN-γ, and interleukin-10, IL-10. Dr. Deb Muth 05:19These create immune modulatory rather than simple immune stimulatory effects. This is a very important distinction because TA1 appears to help balance the immune system rather than simply ramping this up, which theoretically makes it safer in conditions where immune overstimulation would be a problem, such as an autoimmune disease. Hashimoto’s, autoimmune, lupus, Sjogren’s, any of those autoimmune diseases, we don’t want to overstimulate their immune system. So you want to use a product like this that’s non-stimulating. Now, the regulatory status on TA1 is geographically variable and represents one of the challenges in discussing this peptide with patients. It is not FDA-approved in the United States. However, it is approved in several other countries for specific conditions. Dr. Deb Muth 06:19In Italy, it’s approved for the treatment of chronic hepatitis B and hepatitis C. In China, it’s approved for chronic hepatitis B and adjunct immune compromised patients receiving vaccinations or suffering from certain infections. It has an orphan drug designation in the United States for certain cancer indications, but its designation does not constitute approval. It simply provides regulatory incentives for further development. So the evidence base for thymosin alpha-1 is substantial in some areas but comes primarily from non-US populations and research groups, which creates challenges in evaluating quality and generalizable information. So in hepatitis B and C, multiple clinical trials, many conducted in China and Italy, have examined TA1 as an adjunct to antiviral therapy. Dr. Deb Muth 07:21A meta-analysis by Wu and colleagues published in the Journal of Viral Hepatitis in 2013 examined 23 randomized controlled trials, including over 2,000 patients with chronic hepatitis B. The analysis found that combining TA1 with nucleoside analogs like LAMVDUDE or an and TCAVAR improved the hepatitis antigen seroconversion rates by HBV DNA clearance compared to its nucleoside analogs alone. And the effect sizes were modest but statistically significant, with the HBE-AG seroconversion rates improving from about 24% with antivirals alone to 38% in combined therapy. Now in hepatitis C, early trials before the development of direct-acting antivirals showed that TA1 combined with interferon alpha improved sustained virological responses, and compared to interferon alpha, Dr. Deb Muth 08:30Furon alone, particularly in difficult-to-treat populations like those with a genotype one or a high viral load. However, the advent of highly effective direct acting antivirals that achieve SRV rates, sorry, SVR rates exceeding 95%, the role of TA1 in hepatitis C has become less clear. Now in sepsis and critical illness, more recent interest has focused on TA1 in severe cases of sepsis and septic shock. Ren and colleagues published a systematic review and meta-analysis in the Frontiers of Immunology in 2022, analyzing 18 randomized controlled trials, including 1787 patients with severe sepsis or septic shock the pooled analysis showed that ta1 administration was associated with reduced 28-day mortality relative risk at 0.70 meaning a 30 reduction in mortality compared to the standard care alone and the effect appeared Dr. Deb Muth 09:39most pronounced in patients with sepsis-induced immunosuppression measured by HLA-DR expression in monocytes. Now, this is amazing because going forward, we’re going to talk about something that’s commonly known as cytokine storm. Now, cytokine storm really became apparent since 2020 with the viral infection that we’re dealing with in the world today. But they were already looking at this kind of cytokine storm produced by sepsis or sepsis-induced immunosuppression. And it triggered this hyperinflammatory response called the cytokine storm. And many patients who survived the initial phase of the immune suppressed stata, characterized by a T cell exhaustion, reduced antigen presentation, and increased susceptibility to secondary infections. Thymusin alpha-1, TA1, may help restore this immune competence in this phase. However, it’s important to note that patient selection and timing are critical. Dr. Deb Muth 10:43Giving this immune stimulant during a hyperinflammatory phase could theoretically worsen outcomes. So you don’t want to give it to them while they’re in the flare up or the sepsis or the infection, but given to them during the immunosuppression phase afterwards might be beneficial. Now there is also some cancer immunotherapy that we see with TA1 and has been studied as an adjunct in cancer treatment with the hypothesis that it could enhance immune surveillance and response to tumors. And a comprehensive review of Garci and colleagues published in Expert Opinion on Biological Therapy in 2007 examined multiple trials in melanoma, lung cancer, hepatocellular carcinoma, and other malignancies. And the results were mixed. Some trials showed improvement in the immune parameters, increased CD4 in T-cells. improved lymphocyte proliferation responses and some actually showed trends toward improved progression free survival but overall survival benefits were inconsistent and the heterogeneity of the cancer types treatment protocols and outcome measures makes a definitive conclusion difficult as a vaccine adjunct several studies particularly from china have examined ta1 as an adjunct to enhance vaccine responses Dr. Deb Muth 12:11in immune-compromised populations, including the elderly, dialysis patients, and transplant recipients. The rationale is sound. These populations often mount suboptimal antibody responses to vaccines, and TA1’s immune-enhancing effects might improve protection. There are small trials. They have shown improvement in seroconversion rates of hepatitis B vaccines and influenza vaccine in these populations. And though large-scale confirmatory studies are limited, there is a possibility here. Now, on their safety profile, one of the appealing aspects of thymusin alpha-A TA1 is that it’s apparently favorable safety profile in clinical trials. There are some injection site reactions with a little redness, a mild discomfort, and most commonly reported adverse effects. is that their severe adverse events attributable to TA1 have been rare in published trials. However, comprehensive long-term safety data are limited Dr. Deb Muth 13:13And theoretically, concern exists that immune modulation could potentially trigger or exasperate autoimmune conditions in susceptible individuals. Though this hasn’t been clearly demonstrated in clinical trials, integrative medicine considerations for integrative practitioners concerning the thymus and alpha-1, several factors require careful thought. First, sourcing and quality control are critical concerns. Since it’s not FDA approved, TA1 available in the United States typically will come from a compounding pharmacy or an international supplier with variable quality assurance. And pharmaceutical grade product with certificates of analysis showing purity, sterility, and endotoxin testing is essential, but it is readily available from many of these companies. Second, patient selection matters immensely. TA1 should be considered in complex cases where conventional approaches have been insufficient, such as chronic viral infections not responding adequately Dr. Deb Muth 14:21to standard antivirals, post-viral syndromes with evidence of immune dysfunction, cancer patients with immune suppression in consultation with oncology, and it should generally be avoided in active autoimmune disease unless there’s a compelling rationale and close monitoring. Now, TA1 is not a standalone therapy. In cases of chronic viral infection, Comprehensive immune support includes addressing nutritional deficiencies, optimizing vitamin D levels to be between 50 and 80, adequate zinc, selenium, and vitamin A, optimizing gut health since 80% of our immune function is in the gut, you need to optimize gut function. Managing stress from the HPA access dysfunction, chronic cortisol elevation, suppression, and immunity, ensuring adequate sleep, immune memory consolidations during sleep, addressing any metabolic dysfunction, insulin resistance, repairs in the immune function, and the bottom line on thymus and alpha-1 is Dr. Deb Muth 15:26is that it represents legitimate medicine in other countries with a substantial evidence base in specific contexts, but it remains experimental in the U.S., and practitioners using it should provide comprehensive, informed consent about its regulatory status, evidence quality, and source verification. while ensuring it’s part of comprehensive protocols. It is not a magic bullet. And again, what you’re gonna hear me say quite often here is that many of these peptides should be used in conjunction with something else. They should not be used alone. And can peptides be stacked? The answer is yes, they can. So if somebody has an insulin resistance, or a metabolic dysfunction, they can tier TA1 with a GLP-1 like terzepatide or semiglutide. That is not a problem to do that. You need to just work with a practitioner that understands how to do that effectively. So let’s look at BPC-157. Dr. Deb Muth 16:26This is a phenomenon I love BPC-157. Let’s separate it from marketing to actual mechanism of actions here. So BPC-157 stands for Body Protection Compound 157. It is a chain of 15 amino acids that are described as a partial sequence of body protection compound, a protein found in human gastric juice. It has become one of the most hyped peptides in regenerative medicine inside the athletic performance and biohacking communities with claims ranging from healing tendons and ligaments to repairing gut lining or reversing organ damage. The challenge is separating the legitimate mechanisms of science from the marketing hype. The proposed mechanism of BPC-157 are biologically plausible and intriguing. The research suggests that it may influence several growth factor pathways, including vascular endothelial growth factor, VEGF, which promotes new blood vessel formation and has improved better supply of blood flow to injured tissues, theoretically accelerating healing. Dr. Deb Muth 17:40It may also affect fibrous blast growth factor, FGF, and transforming growth factor beta, TGF beta pathways. both involved in tissue repair and remodeling. And some studies actually suggest that BPC-157 modulates inflammatory cascades, potentially reducing excessive inflammation while promoting the resolution phase that allows tissue rebuilding. Now I want to talk just a few moments here about these different tests that we’re talking about tgf beta veg f for those of you who are in our mold world you are very familiar with these uh lab tests we do this to see if you have a mold exposure what’s happening to your body and it’s been very challenging to try to heal this part of the mold illness and manipulate these VEGFs and TGF betas. And so with the fact that BPC helps us modulate this inflammatory cascade, BPC can be very helpful in the world of mold or mycotoxin illness in repairing those parts of the body that have been damaged by the mycotoxins. Dr. Deb Muth 18:48Now there is animal research on BPC-157. It is extensive and primarily from a research group led by pre-drag, oh, I can never say these names, Cyrek at the University of Zagreb in Croatia. Published studies in animal models have shown accelerated healing in a remarkable variety of injury types. A 2011 paper by Chang and colleagues in the Journal of Applied Physiology demonstrated that BPC-157 improved therapy tendon healing in rats with Achilles tendon injuries, and the treated rats showed increased tendon outgrowth, better cell survival in the injured area, enhanced cell migration to the injury site, and improved biochemical strength of the healed tendon compared to controls. Multiple other animal studies have shown similar promising effects. Ligament tears, healing faster in rabbits, muscle damage recovering more quickly in rodent models, gastric ulcers healing in rats given experimental induced ulcerations, inflammatory bowel lesions improving in mouse models of colitis, and even bone to tendon healing showing enhancement in animal studies. Dr. Deb Muth 20:02The breadth of injury types showing benefit in preclinical models explains the enthusiasm of this peptide. However, this is critical. These animal studies, primarily in rodents and rabbits, animal models of injury healing don’t reliably translate to human clinical outcomes. And the doses used in these animal studies when converted to human equivalent doses vary widely. And optimal human dosing is completely unknown at this point. it is all considered experimental and perhaps most importantly there are essentially no peer-reviewed controlled clinical trials in human published in humans published in major medical journals in a 2001 review of arthroscopy and the journal of arthroscopic and related surgery specifically examined in the evidence of bpc 157 and other peptides in musculoskeletal medicine The authors concluded bluntly that BPC-157 lacks evidence from randomized controlled trials and has an unknown safety profile in humans. Dr. Deb Muth 21:09 They emphasized that the jump from animal data to recommending peptides for humans use bypasses the fundamental requirement for Phase I safety studies, Phase II dose-finding studies, and Phase III efficacy trials that would establish whether BPC-157 actually works in humans and whether or not it’s safe. The absence of human safety data is particularly concerning given BPC-157’s proposed mechanisms. Peptides that influence growth factor signaling and angiogenesis could theoretically have off-target effects. Uncontrolled angiogenesis, for instance, is a hallmark of cancer progression. Tumors require blood vessel formation to grow beyond a certain size. And while there’s no evidence that BPC 157 promotes cancer, The complete absence of long term human safety studies means we simply don’t know. This isn’t fear mongering. It’s acknowledging uncertainty and uncertainty exists and understanding that if you’re choosing to use peptides like BPC 157, you are doing it in an experimental model. Dr. Deb Muth 22:17We’re experimenting with the doses that are being used. And there is potential for it to cause cancer cells in your body to grow. And you need to be aware of this and understand the risks that you’re taking when you’re using an investigational or off label use peptide. Now, quality control issues with BPC also exist. It’s not FDA approved for any indication in the US. It’s not approved in any major regulatory jurisdiction worldwide. It’s marketed as a research chemical explicitly to bypass FDA oversight. And commercial sources selling BPC-157 range from compounding pharmacies, which have some quality standards but are not FDA inspected. You can take that for what you want to believe on that one. to overseas suppliers operating with absolutely no quality assurance whatsoever. If you are choosing to use BPC-157, you have to understand who’s manufacturing it for you, where you are getting it from, how pure it is. Dr. Deb Muth 23:26You want to make sure that you have the certificate of analysis and that it does not contain bacterial endotoxins that can contaminate the peptide or degrade the peptide and cause other issues for you. So when you talk about peptides with patients regarding BPC-157 or if you’re listening to this and you’re already using BPC-157 or other peptides, that are quote-unquote not for human consumption, an evidence-based response acknowledges both the appeal and the limitations. And you want to talk about the animal data that’s definitely showing some progress and some potential, but we don’t know what we don’t know in humans. If people are willing to take that risk, that is up to them to do that. But using BPC right now is experimental and people need to be aware of that. Are there evidence-based alternatives for patients with tendon or ligament injuries? Dr. Deb Muth 24:26And there are. There’s PRP, which has been studied in multiple randomized controlled trials. for conditions like lateral epicondylitis, tennis elbow, Achilles issues, patellar issues, knee issues. However, I want to caution you on this too. So the study that was done by Cox and colleagues in muscles, ligaments, and tendons in the Journal of 2014 showed modest benefits in pain and function compared to controls. And though the effects vary by injury type, PRP preparations can be helpful. You have to understand that a lot of times when people are doing PRP injections in their office, they are not doing it exactly the same way it was done in the study. And not to mention, if you’re using your own PRP to heal a ligament or a tendon or help your arthritis and you’re 60 or 70 years old, That is not good quality protein rich plasma. It is old protein rich plasma. And you’re not going to see necessarily the same benefits that you would see if you were using placental tissue or umbilical tissue. Dr. Deb Muth 25:33You also want to address the nutritional deficiencies or support that’s needed for connective tissue healing. And these are collagen peptides dosed at 15 grams a day. And this has been shown in a study by Shaw and colleagues in the American Journal of Clinical Nutrition in 2017 to augment collagen synthesis when combined with intermittent loading. Vitamin C is also an essential cofactor for collagen production and stabilization of collagen structure at a dose of around 500 to 1000 milligrams a day to support this process. You also need to have good adequate intake of copper and zinc. These are cofactors in collagen. Silica is also important. This comes from horsetail extract. This provides additional support as well. So more importantly, I think remembering that rehabilitation matters as well. Doing these protocols without doing some rehab is not going to get you where you want to go. Dr. Deb Muth 26:33There’s a research study by Alfredson and others for Achilles tendinopathy using the control lengthening of muscle tendon units under load to promote tendon remodeling and healing. These protocols have solid evidence and cost nothing beyond professional guidance from a physical therapist. They are important for patients seeking cutting edge regenerative approaches. Stem cell therapies, growth factors, concentrates derived from patients’ own tissues like PRP. These have a lot of good endogenous materials and they have good safety profiles. BPC-157 represents the perfect example of how promising Preclinical science gets marketed far beyond the evidence and it may eventually prove to be valuable. I think it will. But right now that determination does require some human studies and hopefully with the administration that we have right now and Bobby Kennedy, we will actually start to see some of that occur. Now the next peptide I want to talk about is TB4, thymus and beta-4. Dr. Deb Muth 27:36This is a wound healing peptide. It is a 43 amino acid peptide that’s naturally present in virtually all human cells except red blood cells. It’s actually one of the most abundant peptides in the human body, particularly concentrated in blood platelets, wound fluid, and many tissues. It’s naturally ubiquity makes it mechanistically interesting. The body wouldn’t produce it in such abundance if it didn’t serve a function. So the primary role of TB4 involves building G-actin. It’s a form of monomeric actin. And it’s structural protein that forms the microfilaments within the cells, providing cellular structure and enabling cell movement. TB4 prevents from F-actin filaments. I’m not going to talk too much about this. It’s really critical for wound healing as cells need to migrate into the injury sites. Dr. Deb Muth 28:37so the cell shape changes and the cellular response to the injury. So think of this as though you tore your meniscus and the body created all this TB4 to come to that injury to try to heal that site. That’s exactly what the TB4 is doing inside the body when there’s an injury. It’s been shown in research to help produce new blood vessel formation, promote endothelial cells, It helps modulate inflammatory cytokines, potentially reducing TNF-alpha, IL-1, and possibly protecting in programmed cell death, which we call apoptosis. And some studies suggest that it is cardioprotective in its effects in animal models of myocardial infarction, so heart attack, and neuroprotective in other models for brain injury. Now, these remain to be preliminary, but they are being seen. So the regulatory status on TB4 can create some confusion. Dr. Deb Muth 29:40The natural TB4 molecule itself is not FDA approved as a drug. However, TB4 based drug candidates called RGN259, formerly TB4, has been in the development by regen tree for corneal injuries of the dry eye disease. And as of recent updates, this drug is completed phase three trials for its neurotrophic keratopathy, severe corneal condition. But the FDA approval is still pending. So that means that the most advanced TB4-based pharmaceuticals hasn’t yet crossed the finish line for approval. The commercial peptide market further muddies the picture with TB500, which is often described as the synthetic fragment of TB4. However, this extract’s relationship between TB500 and TB4 varies depending on the source. Dr. Deb Muth 30:41So some claim that TB500 is identical to TB4, but positions 1 through 4 suggest it’s a different fragment. and the quality control across suppliers is not existent. So this confusion is part of why recommending TB500 becomes problematic for practitioners and patients, often because they aren’t certain what molecule they’re actually getting. The evidence base for TB4 in humans is limited, primarily to eye research, and the studies from Sohn’s and colleagues published in journals like Vitamins and Hormones in 2016 have examined topical TB4 for corneal injuries and neurotrophic keratopathy, dry eye, and other surface diseases. Now, these studies showed some promise in promoting this, and there is, however, a topical application to the cornea that is vastly different from a systemic injection. So for systemic use in wound healing, musculoskeletal issues, Dr. Deb Muth 31:42cardiac protection, neuroprotection, human clinical trials. There is scarce to non-existent evidence in humans. Most of the evidence remains in animal models or cell culture studies. And a review by Flip and colleagues in the Journal of Investigational Dermatology in 2006 detailed TB4’s effects on the matrix remodeling during wound repair in animal models, showing effects on collagen disposition, granulation, tissue reformation, and wound contraction. Another review by Ho and colleagues in expert opinion on biological therapy in 2007 discussed TB4’s potential in tissue regeneration and regenerative medicine, but noted the field remained largely blank. preclinical. So this is really important again to understand that there is just not enough human data. So there is a concern with cell division and migration. This theoretically exists Dr. Deb Muth 32:45for the potential effects on cancer cells, which would also rely on migration and division and other intended consequences of disrupting normal cellular architecture. These aren’t proven risks, but they are unexplored questions that we need to be aware of when we’re using peptides. This can cause cancerous tissue to grow. Very similar to what we talked about with BPC-157. These are also sold as research chemicals. There is no FDA oversight. So purity, potency, contaminations all still exist for these peptides. Now from an integrative perspective, the natural presence of TB4 in wound fluid and its biological roles in healing are legitimate science. in presence does not equal therapeutic utility. The body tightly regulates where and when and how much TB4 is present through natural production and bypassing that regulation with external dosing may or may not cause us to have beneficial or introduce risk. Dr. Deb Muth 33:49So we need to know that this is experimental use. Those people who are seeking wound healing and tissue repair the evidence-based approach of the body’s own capacity to heal is huge definitely want to be increasing your protein intake optimizing your zinc copper vitamin c and vitamin a and then managing glucose is really important during this time as well so let’s talk about a fun topic now and that’s growth hormone secretagogues this is the anti-aging hype machine these peptides in this category are things like semoralin ipameralin cjc 1220 1295 and others and among the most aggressively marketed in anti-aging and longevity medicine they all share a common goal stimulating the pituitary gland to release more growth hormone and the appeal is understandable. GH levels decline with age, and this decline is associated with increased fat mass, decreased lean muscle, reduced bone density, and other aspects of aging. Dr. Deb Muth 34:55The other times we’ll see growth hormone levels decline significantly is with chronic illness, and the logic is to restore youthful GH levels and youthful physiology. Now, semirelin from an FDA approved diagnostic to compound anti-aging product. Semirelin is a 29 amino acid peptide representing the first 29 amino acids of the full 44 amino acid human growth releasing hormone, GHRH. We talked about this on another episode of the podcast. And you can go back and listen to that one a little bit if you want. This fragment contains the complete biological activity of the full GHRH molecule and it binds to GHRH receptors in the anterior pituitary and stimulates growth releasing peptides, growth hormone releasing peptides. Semirelin was previously FDA approved as diagnostic testing of growth hormone secretion, essentially, to determine if the pituitary could still respond to GHRH stimulation in patients being evaluated for growth hormone deficiency. Dr. Deb Muth 36:06However, the manufacturer was discontinued and there was no longer an FDA approved semirelin product on the market in the United States. What exists now is semirelin available from compounding pharmacies used off label for anti-aging, body composition, and general growth hormone optimization purposes. This represents a significant gray area. Again, compounding medications serve a very important role, but they need to meet certain recommendations and regulations, as we’ve talked about in the past. You want to make sure that your compounding pharmacy that you’re obtaining semirelin from is qualified to do that, that they are doing best practices, and that you’re getting a good product. The theoretical advantage to semirelin over direct growth hormone administration is that it preserves more of the physiological growth hormone secretion patterns. Natural GH is released in pulses, primarily during sleep, not as a continuous elevation. Dr. Deb Muth 37:07So semirelin stimulates the pulses rather than providing a constant super physiological growth hormone level. And that pulsatile pattern is thought to reduce some of the side effects and metabolic concerns that we have with continuous growth hormone exposure. However, the evidence supporting semirelin for anti-aging and body composition in healthy adults is minimal. Most of the data comes from studies conducted in the 1990s when the FDA approved product existed. Not that that means it’s bad. We have drugs that have been in the market for over a hundred years that are still there, that still have the research and are still being used successfully and safely today. So we don’t want to let that really make us think that this product isn’t safe. So a 2006 review from Walker in Clinical Interventions of Aging suggested that semirelin might be a better approach than direct GH for adult onset growth hormone insufficiency, but they do acknowledge that the evidence was limited. Dr. Deb Muth 38:12And although we don’t have any large scale trials that we can examine for semirelin’s efficacy, it is now commonly prescribed. And the optimal dosing for anti-aging purposes is still unknown. It is considered experimental and it does vary from person to person, but it is still unstudied. The effects on cancer risk, cardiovascular disease, metabolic dysfunction over long time periods are also still unknown. I would argue that the side effects or the risk factors of not having growth hormone are equally as bad as the unknowns that we have here. We’re not looking to try to get super physiological doses. We’re trying to restore youthful GH levels. Typically, we’re not trying to restore back to a 20-year-old. We’re trying to restore back maybe 10 years. That is a better way of doing this. And I think that’s important for people to understand. Now, ipamirelin is the ghrelin mimicker. Dr. Deb Muth 39:12Ipamirelin is a pent-up peptide, five amino acid, that acts as a growth hormone secretagogue receptor, a GHS-R agonist. It mimics the action of ghrelin, the hunger hormone, that also stimulates growth hormone release. The proposed advantage over earlier secretagogues is that ipamirelin stimulates growth hormone release without significantly affecting cortisol, prolactin, or other glucose things, which can be increased by growth hormone secretagogues. The regulatory status is clear. Ipamirelin is not FDA approved for any indication. It’s sold as a research chemical. Human evidence is thin. It’s limited to single dose studies examining how quickly it’s absorbed and metabolized with minimal data on dosing and clinical outcomes. Now there are marketing claims for ipamirelin and they are extensive. Dr. Deb Muth 40:13It increases lean muscle mass, it decreases body fat, it improves sleep quality, faster recovery from workouts, enhanced injury healing, better skin quality. The evidence supporting these claims in humans is not available we don’t have it these are claims that are made by the effects that we know from growth hormone so it’s not necessarily a bad thing we know what growth hormone does we know growth hormone does all of these things if ipamorelin is a precursor to that it will obviously help improve those things making that correlation of what growth hormone does So there are safety concerns that mirror the same as any other growth hormone elevating therapy. It can cause fluid retention, joint pain, carpal tunnel syndrome, insulin resistance, glucose intolerance, and theoretically, can it increase calcium? cancer risks? It can because IGF-1 promotes cell proliferation and can inhibit apoptosis in cancer cells. Now remember, your body makes IGF-1. Dr. Deb Muth 41:15If it’s not making enough of it, that’s a problem. If it’s making too much of it, That’s a problem. So just understand that if you are adding these things, and especially in elevated doses, you are taking a potential risk. So there is also now CJC 1295 is a modified GHRH analog of 30 amino acid peptide based on GHRH structure, but with modifications. So it includes the addition of drug affinity complex, DACC, DAC, which involves conjugation with a small albumin binding molecule, dramatically extends the peptide’s half-life from minutes to as much as potentially a week or more. And this creates sustained growth hormone elevation rather than that pulsatile release. There are actually two versions of this. There’s CJC 1295 with DAC, longer acting version, and CJC 1295 without DAC, which is essentially a shorter duration of semirelin. Dr. Deb Muth 42:19And so when we’re comparing products, it is… only the difference between long acting and short acting. The human evidence for CJC 1295 is limited to a single published phase one study by Techman and colleagues in the Journal of Clinical Nutrition and Metabolism in 2006. And the study involves 18 healthy young adults showed that CJC 1295 with DAC produced a sustained elevation of GH and IGF-1 lasting several days after the injection. That’s essentially the entire published human evidence of this peptide. There are no phase two studies examining optimal dose. So that is all considered experimental. And there is no phase three studies examining clinical efficacy. So the sustained GH levels created by CJC 1295 with DAC raises specific concerns because the natural GH secretion It goes up and down, up and down, up and down. Dr. Deb Muth 43:19And that constant elevation may have a different metabolic and cellular effect. And we just really don’t know what that’s going to be yet. So we can understand that elevated IGF-1 levels can theoretically increase cancer concerns and metabolic risks. So rather than always injecting peptides, which are very expensive… You can do other things. And there was a study by Hartman and colleagues in the Journal of Clinical Endocrinology and Metabolism in 1992 that demonstrated the 48-hour fast increased integrated growth hormone secretion five-fold through increased GH levels. Now, the problem with this is fasting for 48 hours is a challenge. And how long is it going to increase the growth hormone secretion without causing issues? Or in general, how long is it going to go up? Dr. Deb Muth 44:19So we have to be cautious about that as well. Sleep optimization is non-negotiable. The majority of growth hormone secretion occurs during sleep, slow wave sleep, typically the first sleep cycle, and poor sleep quality or insufficient sleep typically. can dramatically affect your growth hormone levels. And then high intensity interval training, HIIT resistance training can stimulate growth hormone as well. This was seen in a study by Godfrey and colleagues in sports medicine in 2003 and was examined in exercise-induced growth hormone responses to athletes. So we definitely see these kinds of things. So let’s talk about some longevity peptides now. These expand the telomere. So there’s epitalin and epithalamin and when these are used in anti-aging they can produce some amazing results. Dr. Deb Muth 45:22So epitalin is a synthetic terapeptide, just four amino acids. It was originally synthesized as a simplified version of epithalamine. a pineal gland extract containing multiple peptides. The synthetic four amino acid version was created to isolate what researchers believed might be the active anti-aging component. The mechanism produced for epitalin centers on telomere and telomerase, Telomeres are protective caps at the end of the chromosomes consisting of repetitive DNA sequencing. And every time a cell divides, telomeres shorten slightly because DNA polymers cannot fully replicate the ends of the linear chromosomes. So this progressive shortening acts as a molecular clock. After 50 or 70 divisions, the telomeres become critically short, triggering a cellular senescence. Dr. Deb Muth 46:22This telomere shortening is one mechanism of cellular aging and telomeres in the enzyme that can rebuild telomeres by adding these caps back onto the end of the chromosome. It’s active in stem cells, germ cells, and unfortunately in about 85 to 90% of the cancer cells. In most adult somatic cells, telomerase is inactive or present at very low levels, allowing the telomeres to shorten with division. The research on epitalin suggests it might activate this telomeres act telomeres process primarily from a research group led by Vladimir in Russia. Vladimir Kavasan in Russia. He is a huge peptide researcher or was he passed away with publications dating back to the early 2000s and a study published in bio gerontology in 2000 by Kavasan Dr. Deb Muth 47:25and colleagues examined the effect of epitalin on the lifespan of fruit flies, and they treated fruit flies that showed a modest increase in mean and maximum lifespan compared to its controls by approximately 10 to 15% lifespan extension in some experimental groups. And there were other studies in 2003 that examined epitalamine in a female Swiss-derived mouse. This was done by Ann Simove and colleagues. And the researchers reported that epitalin treatment was associated with increased lifespan as well. And the most cited mechanistic work comes from cell culture studies. And that is also Cavason’s group that published this research in 2003, showing increased telomeres activity in cultured somatic cells again. More recently, between 20 and 25, the series of publications have continued to explore epithelial effects on telomere dynamics in cell cultures. Dr. Deb Muth 48:32So there is a lot of research that’s been done. The mass majority has been done on epithelin. And most of it has been done by a single research group in Russia. There is some restrictions on some of the cell culture data that we’re seeing. And it does show that epithelin sometimes can be described as a regulating hormone. Carcadian rhythm for melatonin production, which is derived by the penile extracts. And however the evidence for this affects minimally and mechanistically unclear, the pineal gland primarily functions as melatonin secretion in that light-dark cycles. So Epithalin or epitalin is not FDA approved. It is not approved for any major regulatory jurisdiction. It is sold as a research chemical only. Dr. Deb Muth 49:33So you need to follow the same safety profiles that we’ve talked about in other episodes and in today’s episodes. And when we’re talking about epithalin, and we’re excited about it being an anti-aging science, we should balance this with the honesty and the evidence of the quality of that evidence. We don’t know its safety effect. We don’t know if it’s going to increase the risk of cancer. We can’t verify that. And we need to be using it in an experimental use of unknown risks only. Of course, diet, physical activity, stress management, sleep quality, all of those things are important for us to be looking at when we’re looking at these peptides. Now, I want to get into some of the brain peptides. This is the nootrophic frontier. C-Max and C-Lank, there is Russian pharmacology that’s done. C-Max and C-Lank represent an interesting case study in how different regulatory environments and research traditions Dr. Deb Muth 50:36create challenges in evaluating this evidence. Both peptides were developed in Russia, are approved for their specific indications and have substantial Russian language and literature supporting their use. However, the FDA approval in the United States is still not there. C-Max is a seven amino acid. It’s a synthetic analog. It is a fragment, particularly ACTH 4 through 10. It’s sometimes called the melanocortin effects because it involves the melanocortin receptors of the central nervous system. CMAX was developed by the Institute of Molecular Genetics of Russia Academy of Sciences and is approved in Russia for several indications, including acute stroke, transient ischemic attacks, cognitive disorders. It has Russian approval and is based on clinical trials primarily in Russia. Dr. Deb Muth 51:39It does help to increase brain-derived neurotrophic factor, BDNF, a protein critical for neuroplasticity, the brain’s ability to form new connections and adapt to the challenges. BDNF supports neuronal survival and promotes growth of these new neurons. C-Max also influences neurotransmitter systems, particularly dopamine and serotonin, and there is some research that suggests it affects on metabolism as well, and endogenous opioid peptides that involve pain reception and mood regulation. So it has some good potentials there. There is also C-Link, which is a hepatopeptide structurally similar to Tufts’ and an immune modulatory peptide. It was also developed in Russia and was approved for anxiety disorders as a neurotropic. Its effects involve anxiolytic effects, possibly through the GABAnergic system or the GABA system of the brain, and immune modulation. Dr. Deb Muth 52:44The Russian research is examined by C-Link for anxiety disorders. and finding reductions in anxiety without sedation. There is a dependency potential or cognitive impairment does not exist like it does with benzodiazepines with C-Link. So that is really good. And they do report attention and memory improvement using C-Link. There is a study that was done in neuroscience and behavioral psychology in 2018 that examined C-Linx effects and proposed that it exerts cytoprotective effects through BDNF pathways similar to C-Max. So both of these are Russian research-based They’re not wrong or fraudulent. It’s just that they are from Russia and we all have our concerns with Russia. However, that does not necessarily mean their research doesn’t hold quality. Dr. Deb Muth 53:49Neither peptide is approved by the FDA, and so you are using this off-label. The same rules apply for all of the other peptides that we’ve talked about that are produced off label. You want to do the same things that you would do with anything else. Good protein, omegas, B vitamins, acetylcarnitine, exercise, sleep, all of that still applies when we’re using these peptides. So I want to talk briefly about clinical decision and framework when we’re looking at this. First and foremost, we always want to go to FDA-approved peptides. Secondly, we would look at international approval with peptides that are established in other countries but lack FDA approval. And then preclinical evidence only or experimental peptides. These can be used, but they are not ethically recommended in the traditional medicine world. Dr. Deb Muth 54:50 If patients use them, we need to have appropriate counseling about the evidence surrounding them, the safety, and where to find them. how to find them and how to ask for these certificates of analysis. So I think it’s really good that we were exploring all these peptides and understanding what they are. There’s a lot of controversy out there. There’s a lot of concern out there. And what we can say with confidence is that peptides are powerful biological signaling molecules. Some peptide based medications, semi-glutide, triseptide, PT 141, Lupron that are all FDA approved. can dramatically improve outcomes in patients that are obviously selected for the correct ones. There are many other peptides that we address that are integrative and longevity space in the regenerative medicine. These peptides are all experimental. That does not automatically make them wrong. Dr. Deb Muth 55:50It just means that we need to be honest about what we’re doing with them and we need to be cautious with the patients so that they can make a decision to be part of an experimental study. in looking at how to use these peptides. So peptides are tools like any other tools. They work best in the hands of skilled people, and they are applied to appropriate situations, integrating into comprehensive approaches that address root causes. The most powerful peptide administered to a patient with untreated inflammation, hormonal chaos, nutritional deficiencies, and disorders of sleep will disappoint. The simplest evidence-based interventions apply. to a patient whose foundational physiology has been optimized. And this is the art of the science of peptide, right? If done right, respecting both the power of these molecules and the complexity of human beings that we are privileged to serve can make a difference in their lives. So thank you for listening to this episode. Dr. Deb Muth 56:52I hope this was helpful. If you can know of somebody that might benefit from this, please like, share, and subscribe. It means a lot to us. And I hope you join us for our next episode of Let’s Talk Wellness Now. Welcome to Let’s Talk Wellness Now, where we bring expert insights directly to you. Please note that the views and information shared by our guests are their own and do not necessarily reflect those of Let’s Talk Wellness Now, its management, or our partners. Each affiliate, sponsor, and partner is an independent entity with its own perspectives. Today’s content is provided for informational and educational purposes only and should not be considered specific advice, whether financial, medical, or legal. While we strive to present accurate and useful information, we cannot guarantee its completeness or relevance to your unique circumstances. We encourage you to consult with a qualified professional to address your individual needs. Dr. Deb Muth 57:54Your use of information from this broadcast is entirely at your own risk. By continuing to listen, you agree to indemnify and hold Let’s Talk Wellness Now and its associates harmless from any claims or damages arising from the use of this content. We may update this disclaimer at any time and changes will take effect immediately upon posting or broadcast. Thank you for tuning in. We hope you find this episode both insightful and thought-provoking. Listener discretion is advised.The post Episode 258 – Investigational Peptides: What's Promising, What's Hype & What You Must Know first appeared on Let's Talk Wellness Now.

This week's stories: Smartphone App Catches What Sleep Trackers Miss A 2026 trial found that suvorexant, a popular prescription sleep drug, improves sleep quality scores — but worsens morning alertness and cognitive function while improving afternoon and evening performance. The study used a smartphone app to pulse users throughout the day, revealing a split-time-of-day signal that traditional sleep scales miss entirely. Optimizing your sleep dashboard and optimizing your waking performance are not the same thing. Sources: https://jamanetwork.com/journals/jama/fullarticle/suvorexant-ema-trial-2026 https://www.ncbi.nlm.nih.gov/pmc/articles/suvorexant-daytime-performance Bats Are Breaking the Telomere Model A 2026 bioRxiv preprint on the tropical bat species Molossus molossus found that these animals live unusually long lives with almost no telomere shortening — challenging the assumption that telomere erosion is a universal driver of mammalian aging. Instead, the bats maintain genome integrity through superior DNA repair and oxidative stress management driven by the metabolic demands of flight. Telomere length may be a symptom, not the cause — and the longevity industry has been measuring the wrong thing. Sources: https://www.biorxiv.org/content/molossus-molossus-telomere-longevity-2026 https://www.nature.com/articles/telomere-bat-aging-2026 The Fenugreek Hack That Cuts Glucose Spikes by Up to 20% Soaking fenugreek seeds overnight and consuming them before meals has been shown across multiple small human trials to reduce fasting glucose and post-meal glucose spikes by 5 to 20 percent. The mechanism is dual — soluble galactomannan fibers slow carbohydrate absorption while bioactive compounds improve insulin receptor sensitivity in muscle and liver. It's a cheap, food-grade, CGM-trackable lever that most people have never tried. Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/fenugreek-glucose-clinical-review https://pubmed.ncbi.nlm.nih.gov/fenugreek-insulin-sensitivity-trial The First Longevity Supplement to Move Vascular Age Like Exercise A randomized, double-blind, placebo-controlled trial out of the University of Surrey found that a multi-ingredient longevity stack targeting NAD metabolism, glycation control, and mitochondrial function improved three independent vascular aging markers simultaneously in healthy adults over 40. Arterial stiffness improved by 1.18 meters per second — equivalent to reversing roughly a decade of age-related decline. Blood pressure dropped 6.1 millimeters of mercury, outperforming aerobic exercise, HIIT, the DASH diet, omega-3s, and magnesium in head-to-head comparisons. Sources: https://papers.ssrn.com/sol3/papers.cfm?abstract_id=6241278 https://clinicaltrials.gov/study/NCT06145087 https://novoslabs.com/blog/supplements/novos-core-clinical-trial-results-longevity-supplement https://www.medicalnewstoday.com/articles/longevity-supplement-improves-vascular-aging-markers-clinical-trial-novos-magnesium-gi Carbon Monoxide Exposure Is Up 50% in 2026 — And Most People Won't Know Until It's Too Late Maryland state data reported by CBS News shows emergency room and urgent care visits for carbon monoxide exposure jumped from 167 cases in 2025 to 251 so far in 2026 — a nearly 50 percent increase. CO binds to hemoglobin more tightly than oxygen, quietly starving your brain, heart, and muscles while producing symptoms that mimic fatigue, brain fog, and the flu. The CDC estimates more than 400 Americans die from unintentional CO poisoning every year — and most of them never saw it coming. Sources: https://kffhealthnews.org/morning-briefing/friday-march-6-2026 https://www.cdc.gov/niosh/topics/co/default.html https://www.cbsnews.com/news/carbon-monoxide-exposure-maryland-spike-2026 Fat Plus Carbs Around Training May Actually Be the Metabolic Move A 2026 study found that combining fat with a carbohydrate-rich period during or around exercise improves insulin sensitivity and fat oxidation in the recovery phase — directly challenging the long-held "never stack fat and carbs" rule. The mechanism appears to be a mixed-fuel training effect: the liver and muscle learn to manage glucose and fat concurrently when both are present during high metabolic demand. Context changes the calculus, and the workout itself may be the variable that flips the equation. Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/fat-carb-exercise-metabolism-2026 https://pubmed.ncbi.nlm.nih.gov/fat-carbohydrate-insulin-sensitivity-training All source links are provided for direct access to the original reporting and research. This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on circadian biology, neurodegeneration signals, cognitive training, caffeine strategy, and supplement regulation. Host Dave Asprey connects emerging science, behavioral data, and policy shifts into practical frameworks you can use to build a resilient, adaptable health stack. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: sleep medication daytime performance, suvorexant alertness, sleep score vs performance, telomere aging myth, bat longevity telomeres, DNA repair aging, fenugreek blood glucose, fenugreek insulin sensitivity, CGM glucose hack, longevity supplement clinical trial, vascular aging markers, arterial stiffness reversal, pulse wave velocity supplement, carbon monoxide poisoning 2026, CO detector home safety, environmental toxin biohacking, fat and carbs exercise, macronutrient timing training, insulin sensitivity workout, metabolic flexibility training, biohacking news, longevity research 2026 Thank you to our sponsors! - The One Device | Use code DAVE for $10 off at theonedevice.com/dave - Screenfit | Get your at-home eye training program for 40% off using code DAVE at https://www.screenfit.com/dave. Resources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Intro 00:20 – Trailer 00:57 - Story #1: Sleep Meds & Morning Performance 02:42 - Story #2: Bats & the Telomere Model 04:33 - Story #3: Fenugreek & Glucose Spikes 06:00 - Story #4: Multi-Ingredient Longevity Stack Trial 07:51 - Story #5: Carbon Monoxide: The Silent Threat 09:45 - Story #6: Fat + Carbs Around Exercise 11:25 - Weekly Roundup See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

How a CEO took over a public company and made it his mission to live better, longer and healthier. Listen to this episode to hear how he can help you as well!In this episode of Startup to Stock Exchange, Seth Farbman sits down with Lance Friedman, CEO of Welgevity 360, who says he's in the best shape of his life at 64. After years of intense workouts but disappointing results, Lance discovered the impact of hormone optimization, peptides, metabolism science, and personalized health protocols. Today he says he's operating with the energy, strength, and mental clarity he didn't even have decades ago.His mission is simple:Help people live longer, live better… and stay strong while doing it.If you're interested in longevity, entrepreneurship, and the future of healthcare, this episode is for you.Seth's CompaniesVstock Transfer – https://www.vstocktransfer.com/Share Media – https://www.sharemedia.co/Listen to the ShowApple Podcasts – https://podcasts.apple.com/us/podcast/seth-farbman-on-podcast-from-startup-to-stock-exchange/id1356667808Spotify – https://open.spotify.com/show/54i7xkWaAALAFrUvk4WZcNConnect with SethLinkedIn – https://www.linkedin.com/in/sethfarbman/Instagram – https://www.instagram.com/sethfarbmanstockTikTok – https://www.tiktok.com/@sethfarbmanTwitter (X) – https://x.com/sethfarbman1About the ShowFrom Startup to Stock Exchange, hosted by entrepreneur and investor Seth Farbman, spotlights the journey of founders and CEOs as they scale their companies from early ideas to public markets. Each episode features candid conversations with leaders across industries, offering insights on growth, fundraising, branding, and the mindset it takes to build a company that lasts.Chapters: 00:00 – Introduction01:18 – Taking Over a Company in Bankruptcy03:12 – Why the Orthopedics Business Was Unsustainable04:52 – Lance's Personal Health Journey Begins06:45 – The Airport Encounter That Changed Everything08:13 – Discovering Peptides, Hormone Therapy, and Longevity Protocols12:07 – The Rise of Functional Health13:35 – Building Clinics and Expanding the Business15:29 – Biological Age, Telomeres & Longevity Science18:18 – The 360° Wellness Approach20:46 – The Business Model Behind Welgevity 36023:13 – High-Margin Healthcare24:10 – Telehealth vs Physical Clinics25:43 – Turning Passion Into a Business Mission28:05 – Mental Health, Brain Longevity & Cognitive Protection28:57 – The Importance of Sleep29:39 – The Vision: A Billion-Dollar Longevity Company30:28 – Final Thoughts: Living Longer and BetterConnect with SethLinkedIn – https://www.linkedin.com/in/sethfarbman/Instagram – https://www.instagram.com/sethfarbmanstockTikTok – https://www.tiktok.com/@sethfarbmanTwitter (X) – https://x.com/sethfarbman1Connect with Seth LinkedIn – https://www.linkedin.com/in/sethfarbman/ Instagram – https://www.instagram.com/sethfarbmanstock TikTok – https://www.tiktok.com/@sethfarbman Twitter (X) – https://x.com/sethfarbman1

Scientists used to say cells had a countdown timer. Dr. Bill Andrews proved it, then spent decades figuring out how to reset it.In this episode, Dr. Bill Andrews explains why aging isn't just random wear and tear, but an evolved mechanism to eliminate the longer-lived. He shares the story of discovering the enzyme that can rebuild the ends of our chromosomes, effectively resetting the cellular clock in a petri dish. We explore the reality of gene therapy, why it works, why it's risky, and where you can actually get it today. He also breaks down the "tug of war" inside your cells, explaining how lifestyle accelerates the loss, and how specific nutraceuticals are finally adding fighters to the other side."No matter what else we do to try to cure aging, we will never succeed, unless we also solve the telomere shortening problem. – Dr. Bill AndrewsSupport the show and get 50% off MCT oil with free shipping – just leave us a review on iTunes and let us know!https://podcasts.apple.com/us/podcast/live-beyond-the-norms/id1714886566About Dr. Bill Andrews:Dr. Bill Andrews is a molecular biologist and longevity researcher pioneering telomere science to combat aging. With a PhD in molecular and population genetics, he holds over 50 patents, has published 50+ papers, and co-discovered human telomerase. As founder and CEO of Sierra Sciences, he focuses on telomerase-activating compounds to extend healthspan, driven by a lifelong mission to "cure" aging.Mentioned Resources:- Telo-Vital by Touchstone Essentials: telomerase-inducing supplement: https://thegoodinside.com/shop/product/telo-vital - BioViva: gene therapy clinical studies: https://bioviva-science.com/ - Dr. Bill Andrews' videos on telomeres and aging: https://www.dropbox.com/scl/fi/jqxqivkf4csha2awiloqn/Key-Videos-and-Documentaries-100925.docx?rlkey=yg8pdi3gxt59sb463ygbhluba&e=1&st=ioc75y89&dl=0 Connect with Dr. Bill Andrews:- Website: https://sierrasci.com - Email: bandrews@sierrasci.comConnect with Chris Burres:- Website: https://www.myvitalc.com/ - Website: http://www.livebeyondthenorms.com/ - Instagram: https://www.instagram.com/chrisburres/ - TikTok: https://www.tiktok.com/@myvitalc - LinkedIn: https://www.linkedin.com/in/chrisburres/ DisclaimerThe content shared in this podcast is intended for educational and informational purposes only. It does not constitute medical advice of any kind, nor does it include any specific claims or guarantees. The views expressed are based on personal experiences, research, and individual perspectives, and are meant to inspire and inform listeners on topics related to wellness, lifestyle, and personal development.We strongly encourage all listeners to consult with a qualified professional or licensed expert before making any decisions related to health, finances, or other sensitive areas of life. Thank you for tuning in—and for taking proactive steps toward a more informed, intentional life.

Worried that aging means decline and chronic pain? Discover how to influence your biological age and reclaim energy and mobility. Join me and my guest, Bettina Gordon-Wayne, to explore how your beliefs and daily habits affect your biological age and how to begin shifting it today. Concerned about the negative impacts of EMFs on your health? Save up to 50% on Harmoni Pendant here: https://thewellnessengineer.com/harmoni Is your brain keeping you in pain? Download my free 10-question quiz here: https://www.thewellnessengineer.com/yourbrainandpain In this episode, you'll learn: ⏰ 00:00 Introduction ⏰ 02:31 Cancer, Motherhood at 44 and the Wake-Up Call ⏰ 09:17 The Power of Mindset in Healing ⏰ 19:44 Scientific Evidence Supporting Mind-Body Connection ⏰ 26:29 Practical Steps to Reverse Aging ⏰ 33:13 How Your Mindset Can Impact Your Aging ⏰ 38:47 The Magic is in the Fundamentals ⏰ 42:11 Telomeres and Biological Age ⏰ 48:15 Aging is a Choice ⏰ 54:09 The ONE thing you can do to activate self-healing Check out Bettina Gordon-Wayne's Bio: Bettina Gordon-Wayne is an international journalist, TEDx speaker, Certified Mental Strength Trainer, focused on mindset, longevity, and human performance. With over 20 years of experience interviewing world leaders and experts, her work is grounded in science, research, and real-world application. Her focus on longevity became personal after becoming a first-time mother at 44 and facing cancer just a few years later. Rather than accepting decline as inevitable, Bettina immersed herself in the science of biological aging and neuroplasticity, discovering how mindset and lifestyle directly influence health. She is the author of The Joy of Later Motherhood and the founder of Younger With Age, helping high-achieving women thrive mentally, emotionally, and physically… and redefine what's possible at midlife and beyond. Take this fun quiz to find out if you're aging faster (or slower) than you think! Discover simple ways to influence your biological age and turn back the clock: https://www.bettinagordon.com/quiz  Connect with Bettina Gordon-Wayne: Website: https://www.bettinagordon.com TEDx Talk: https://www.youtube.com/watch?v=h7CfQI64uqQ TikTok: https://www.tiktok.com/@bettina.gordon Instagram: https://www.instagram.com/bettina.gordon/ LinkedIn: https://www.linkedin.com/in/bettinagordon/ ***** Hi there! I am Jane Hogan, the Wellness Engineer, and the host of Wellness By Design. I spent 30 years designing foundations for buildings until the pain and inflammation of rheumatoid arthritis led me to hang up my hard hat and follow my heart. Now I blend my backgrounds in science and spirituality to teach people how to tap into the power of their mind, body and soul. I help them release pain naturally so they can become the best version of themselves.  Wellness By Design is a show dedicated to helping people achieve wellness, not by reacting to the world around them but by intentionally designing a life based on what their own body needs. In this show, we explore practices, methods, and scientific principles that help naturally relieve pain and inflammation. Learn more at https://thewellnessengineer.com Connect with Jane:  Facebook: https://www.facebook.com/JaneHoganHealth/ Instagram: https://www.instagram.com/thewellnessengineer/ 

What if biohacking and AI revealed you were aging 18 years faster than you thought? Most high performers assume they're doing fine. You exercise. You eat well. Your labs come back “normal.” And yet your biology could be aging faster than your calendar.In this episode, I sit down with Dave Pascoe, the famous biohacker who has one of the slowest measured rates of aging in the world. At the end of an intensive health retreat in India, he shares his latest discoveries and methods on how he supercharges his rejuvenation and maintains his bio-regeneration edge. Dave tracks close to 1,000 blood markers, has sequenced his entire genome, and uses AI to analyze his labs, wearables, and supplement protocols. We talk about why “normal range” may be far too low a standard and how chronic stress can accelerate aging, even when someone looks fit on the outside. We also explore how artificial intelligence can help organize massive amounts of health data in ways the human brain simply cannot. And we challenge a core belief in Western medicine, asking whether joint damage truly requires replacement or if the body may still have more capacity to repair than we've been told.Dave talks about: 00:00 Regenerative medicine can prevent unnecessary joint replacement02:10 Luxury health retreats now compress months of testing into days05:10 Telomeres reveal accelerated aging in “healthy” people07:00 Chronic stress can age the body faster than poor fitness08:45 Mindset shifts measurably reduce biological stress10:40 Tracking biomarkers beats symptom-based health decisions16:35 AI enables real-time health optimization across health data22:30 Smarter supplement protocols balance precision and practicalityAdditional Resources:✨ Learn more about how to live a long and pain-free life: https://joykongmd.com/ ✨ Follow me on Facebook: https://www.facebook.com/stemcelldrjoy/ ✨ Follow me on Instagram: https://www.instagram.com/dr_joy_kong/ —✨ Follow Steve White on Instagram: https://www.instagram.com/thebrae100/✨ Connect with Steve White: https://www.brae100.com/—Dr. Joy Kong is a regenerative medicine and anti-aging expert. Her podcast is part of her mission to reduce suffering and elevate happiness. Join us every week for the latest holistic health insights that will help you live a long and pain-free life.

As pharmaceutical companies begin rolling out anti-aging drugs for dogs, many pet parents are being told these medications can extend lifespan and prevent cognitive decline. But what are these drugs actually doing inside the body, and at what cost?In this episode, Angela sits down with Carter Easler, Director of Research and Education for CBD Dog Health and MycoDog, to break down the science behind emerging longevity drugs like rapamycin and Loyal. Carter also shares insights from coordinating the Senior Dog Study on cognitive decline, as they explore how pharmaceutical interventions compare to natural strategies that work with the body's own repair systems, including fasting, adaptogens, medicinal mushrooms, and support for the endocannabinoid system.If you have a senior dog, or want to learn about supporting your aging dog before their golden years, this is an episode you won't want to miss.Episode Recap:Angela and Carter talk about the rise of anti-aging drugs for dogs on the market, and why aging is at its core, a loss of homeostasis. (00:00)Rapamycin for dogs, what it does and why it was originally developed. (04:41)Do anti-aging drugs support longevity, or interfere with the body's natural repair processes like autophagy and cellular balance? (07:48)How fasting and restricted feeding windows naturally activate autophagy, support cellular cleanup, and may help extend lifespan in dogs. (11:10)Telomeres, “zombie cells,” and mTOR: how adaptogens, medicinal mushrooms, and hemp modulate aging pathways to support cellular balance instead of blocking the body's natural repair systems. (16:41)Why pharmaceutical “one-target” drugs can create a narrow therapeutic window and unintended side effects, while adaptogens and medicinal mushrooms support all 12 hallmarks of aging. (20:59)The 12 hallmarks of aging explained, from telomere shortening and mitochondrial dysfunction to microbiome imbalance, and how these anti aging drugs are targeting just one of these. (26:06)Why supporting the endocannabinoid system becomes increasingly important as pets grow older. (31:09)Loyal, the upcoming “anti-aging” injection for dogs, undisclosed mechanisms of action, and the importance of informed consent before new veterinary drugs reach the market. (35:20)Why proactive pet wellness should prioritize food, lifestyle, and adaptogenic plant support first, and where pharmaceuticals truly belong in veterinary care. (41:20)They dive into the science behind specific adaptogens and plant compounds, from mitochondrial support and telomere health to metabolic balance and autophagy, and why full-spectrum, whole-plant synergy matters more than isolated compounds. (44:28)Episode Resources:Download Angela's Resources including her Senior Dog Protocol and more at AngelaArdolino.com/podcast-downloads Prospective Evaluation of a Mushroom Derived Nutraceutical in Dogs with Cognitive DeclineWhat We Learned from the Senior Dog StudyMushrooms and Adaptogens for Canine Cognitive DysfunctionHave a question about your pet that you want answered on the podcast? Email us at Angela@AngelaArdolino.com Sign up for episode reminders and updates from Your Natural Dog with Angela ArdolinoVisit Angela Ardolino's website for more holistic pet health education: www.AngelaArdolino.comFollow Your Natural Dog on Facebook and Instagram and if you want to see what Angela is up to, follow her on Facebook or join our CBD & Holistic Pet Advice Facebook Group.

Keywordslongevity, telomeres, aging, telomerase, nutraceuticals, health, wellness, anti-aging, lifestyle, scienceSummaryIn this episode of the Wise Divine Women podcast, Dr. Bill Andrews discusses the science of longevity, focusing on telomeres and their role in aging. He explains how telomeres function, the significance of telomerase, and the potential of nutraceuticals to promote telomere health. Dr. Andrews emphasizes the importance of a healthy lifestyle in conjunction with these products and shares his personal journey into the field of anti-aging research. The conversation concludes with insights on maintaining a positive outlook towards longevity and the importance of foundational health.Product introduced in the show Telo- VitalTelo-Vital: Target Aging Where It StartsYour daily choices—from nutrition and exercise to stress management—play a powerful role in how your body ages. At the cellular level, telomeres—those protective endcaps on your chromosomes—naturally shorten over time. Stress, toxins, and oxidative damage can accelerate this process, impacting how you feel and function as you age.Telo-Vital is a premium anti-aging supplement developed by Dr. Bill Andrews, based on his lifetime of groundbreaking telomere science. It's crafted to nourish your cells and defend against premature aging, so you can live with energy, clarity, and vitality.Show Takeaways* Aging is not a necessary process; it's a survival mechanism.* Telomeres shorten with each cell division, impacting aging.* Telomerase can potentially reverse aging by re-lengthening telomeres.* Nutraceuticals can induce telomerase production to support telomere health.* A healthy lifestyle is crucial for reducing telomere shortening.* The average telomere length can be misleading without proper context.* It's essential to build a foundation of health before using longevity products.* Optimism can positively influence aging biomarkers.* Dr. Andrews has a passion for finding a cure for aging.* Longevity science is evolving, and new products are being developed.Chapters00:00 Introduction to Longevity Science01:50 Understanding Telomeres and Aging05:31 The Role of Telomerase in Longevity09:24 Nutraceuticals and Telomere Health13:07 The Importance of a Healthy Lifestyle18:31 Bill Andrews' Journey into Anti-Aging23:08 Final Thoughts on Longevity and WisdomIf this stirred something in you, this may be your invitation to understanding greater wisdom within..You can book a Wise Divine Health Clarity Call at danairvine.com.

Chris Duffin sits down with legendary molecular biologist and endurance athlete Dr. Bill Andrews, a man who truly walks the walk when it comes to resilience. In this episode, we explore Dr. Bill Andrews's remarkable pursuits as an ultramarathon runner—including competing in grueling events like the Death Valley Badwater 135 and high-altitude races in the Himalayas, defying what most believe possible for a 70-plus-year-old. Beyond his athletic feats, Dr. Bill Andrews shares his groundbreaking work on the human telomerase gene—an innovation that reshaped how we understand aging at the cellular level.   Practical Longevity Tips You Can Use Today Dr. Bill Andrews doesn't just share science—he gives you actionable ways to slow down cellular aging and protect your longevity: The impact of lifestyle choices (yes, he discusses alcohol, stress, diet, and even meditation) Nature's defenses: antioxidants, anti-inflammatories, and a sneak peek into cutting-edge nutraceuticals like Telovital Debunking myths around anti-aging products and the best, science-backed tests to measure your cellular age   Dive deeper! Learn more about Dr. Bill Andrews, his quest for immortality, and his favorite anti-aging supplements at Sierra Sciences: https://sierrasci.com/dr-bill-andrews/

In this episode of Keeping Abreast, Dr. Jenn Simmons sits down with Dr. Joseph Dituri, a biomedical engineer, hyperbaric medicine specialist, and former U.S. Navy saturation diver, to explore the science of healing, aging, and human resilience.Drawing from his clinical work in hyperbaric medicine and his recovery from a traumatic brain injury, Dr. Dituri explains how oxygen, pressure, and controlled physiological stress affect inflammation, sleep quality, immune function, and cellular repair. Together, they examine the evidence behind biological versus chronological age, the role of muscle and bone health in longevity, and the evolving, evidence-informed use of hyperbaric oxygen therapy in healing and cancer support. In This Episode, You'll Learn:What happens to the human body when it lives under pressure for 100 days underwaterHow hyperbaric oxygen therapy impacts inflammation, immune function, sleep, and agingThe difference between biological age vs. chronological age and why it matters.Why muscle and bone health are critical pillars of longevityHow healthy stress can strengthen the brain, body, and immune systemThe science behind collagen synthesis, stem cells, and tissue repairWhat the research actually says about hyperbaric medicine and cancerHow to identify qualified, safe hyperbaric centers and avoid poorly run facilitiesEpisode Timeline Highlights:00:00 Introduction to Dr. Joe Dituri and His Mission03:08 What Hyperbaric Medicine Is and How It Works05:54 Why He Chose to Live Underwater for 100 Days08:54 Daily Life, Work, and Challenges Beneath the Ocean11:53 Sleep, Brain Function, and Cognitive Changes Under Pressure14:53 Inflammation, Telomeres, and Measuring Cellular Health18:05 The Core Science Behind Hyperbaric Oxygen Therapy28:50 Isolation, Connection, and Human Biology33:49 Biological Age vs. Chronological Age50:35 Hyperbaric Therapy for Health Optimization53:17 Collagen, Tissue Healing, and Regeneration56:07 Hyperbaric Medicine and Cancer Support01:06:50 Treatment Frequency, Duration, and Expectations01:12:03 How to Find Safe and Qualified Hyperbaric Centers01:15:52 Longevity, Optimization, and What's NextWhere to Find Dr. Joseph Dituri (Dr. DeepSea)Website: https://drdeepsea.com/Instagram: www.instagram.com/drdeepseaTo talk to a member of Dr. Jenn's team and learn more about working privately with RHMD, visit: https://jennsimmons.simplero.com/page/377266?kuid=327aca17-5135-44cf-9210-c0b77a56e26d&kref=vOKy0sAiorrKTo get your copy of Dr. Jenn's book, The Smart Woman's Guide to Breast Cancer, visit: https://tinyurl.com/SmartWomansBreastCancerGuideTo purchase the auria breast cancer screening test go here https://auria.care/ and use the code DRJENN20 for 20% Off.Connect with Dr. Jenn:Website: https://www.realhealthmd.com/Facebook: https://www.facebook.com/DrJennSimmonsInstagram: https://www.instagram.com/drjennsimmons/YouTube: https://www.youtube.com/@dr.jennsimmons

Welcome to the latest episode of L.I.F.T.S, your bite‑sized dose of the Latest Industry Fitness Trends and Stories. In this episode of, hosts Matthew Januszek and Mohammed Iqbal sit down with Dr. Bill Andrews: molecular geneticist, inventor, and telomere pioneer to explore what actually causes human aging and whether it can be slowed, stopped, or even reversed. Key topics covered: What telomeres are and why they determine human lifespan. Why aging isn't random, but biologically programmed. The real relationship between telomeres and cancer. How exercise, inflammation, and lifestyle impact cellular aging. Why most anti-aging products fail scientific scrutiny. The role of telomerase in extending cellular life. What longevity influencers often get wrong. Practical habits that may slow biological aging.

This week, Linda sits down with renowned molecular biologist Dr. Bill Andrews, one of the world's leading researchers on telomeres and human longevity. Dr. Andrews has dedicated over 30 years to understanding why we age—and how we might stop or even reverse the process. In this powerful conversation, he breaks down what telomeres really do, why they shorten, and what current science can (and cannot) promise when it comes to living longer, healthier lives. He also discusses Televital, the only supplement he says has been shown to induce telomerase, and why true age reversal still requires large-scale gene therapy research. If you want a grounded, science-driven look at longevity without the hype, this is an episode you'll want to hear. What Linda Talks About With Dr. Andrews What telomeres are and why they control how long our cells live Why shortening telomeres is the real driver of aging What telomerase is and why activating it matters The difference between slowing aging and reversing aging Why most "anti-aging" products only change biomarkers—not true aging The "tug-of-war" analogy that explains how telomere length changes How Televital compares to other supplements Why gene therapy may be the key to true age reversal How much research funding is needed to move longevity science forward Why some aging claims sound promising but fail the "Betty White Test" Why Dr. Andrews believes real age reversal is possible in our lifetime Main Topics Covered Understanding the Cellular Clock of Aging Dr. Andrews explains how every cell in the body loses a bit of its telomeres each time it divides. When telomeres get too short, cells can no longer replicate—and this is a major reason we age. The Telomerase Breakthrough He clarifies why the only way to actually lengthen telomeres is through telomerase activation, and why most supplements claiming to do this simply cannot. Why Slowing Telomere Shortening Still Matters Even if something cannot reverse aging, slowing the rate of cellular decline can still have meaningful long-term impact. Dr. Andrews explains why Televital is the only supplement shown to induce telomerase, and how it affects the "tug-of-war" between shortening and lengthening. Biomarkers vs. True Reversal From DNA methylation to glycosylation, many companies claim "reversed aging" based on biomarkers. Dr. Andrews outlines why these measurements don't mean actual age reversal—and what real reversal would require. The Betty White Test Dr. Andrews' signature test: if a product truly reverses aging, you should visibly look, feel, and function like you did decades earlier—not just change lab numbers. Gene Therapy: The Future of Longevity He discusses ongoing efforts to develop gene therapy capable of fully restoring telomerase to adult cells—and why he believes it's possible within the next few years with adequate research funding. The Company Bringing His Research to Market Dr. Andrews explains why he partnered with Touchstone Essentials to launch Televital and praises their commitment to health-first product development rather than profit margins. He also highlights other Touchstone Essentials products including: Glucocontrol (converts sugar into fiber) Zeolite-based detox products for heavy metals and toxins Fulvic acid (the active component of shilajit) Where to Find the Product Dr. Andrews Recommends Televital & Touchstone Essentials: https://thegoodinside.com  

Daylight Savings Time changeover health myths busted; A doctor breaks her ankle and is billed $64,000 in uncovered expenses; Vitamin D shields life-prolonging telomeres, may help depression; The vaunted DASH Diet for hypertension faces off against low-carb alternative; The critical first 1000 days after conception—early life sugar avoidance yields major later life health dividends; Do you really need hot water to disinfect your hands?

Dr. Bill Andrews: Anti-Aging & Telomeres_The TrulyFit Podcast welcomes Dr. Bill Andrews, Sierra Sciences' founder and CEO, is a scientist, athlete and executive who is known for pushing the envelope and for challenging convention. They discuss:_- Anti Aging Science- Telomeres and Telemorase - The possible "why" behind death- Tele Vital Supplement- ...much more_Learn more about him here:IG: @fittonnutritionhttps://sierrasci.com/_#fasting #nutrition #healthpodcast #trulyfitpodcast #Telomeres #Telemorase #drbillandrews #aging #wellness #stevewashuta

Can We Slow — or Reverse — Aging? Telomeres, Telomerase & LongevityClick On My Website Below To Schedule A Free 15 Min Zoom Call:www.Over40FitnessHacks.comOver 40 Fitness Hacks SKOOL Group!Get Your Whoop4.0 Here!Dr. Bill Andrews - Telomere Health & Longevitywww.thegoodinside.com - Touchstone Essentials supplements.Email: BAndrews@SierraSci.comGuest snapshot: Dr. Bill Andrews—biotech veteran and founder of Sierra Sciences—has spent his career chasing a practical way to slow (and ultimately reverse) human aging. Inspired by a childhood mission from his dad to “find a cure for aging,” he helped lead the discovery of human telomerase at Geron in the 1990s.Why we age: Aging isn't great for the individual, but it benefits the species (greater diversity and adaptability). Mechanistically, “wear and tear” accumulates—and our ability to replace damaged cells is capped by the Hayflick limit.Ride tickets analogy: Every time a cell divides it “uses a ticket.” Those tickets are telomeres (the DNA caps on chromosomes). When tickets run out, cells enter senescence and die.Telomerase: In reproductive cells, the enzyme telomerase adds tickets back, keeping telomeres long—why children aren't born “older” than their parents. In most other cells, the telomerase gene is repressed.His team screens plant extracts to dislodge repressor proteins on the telomerase gene “dimmer switch,” aiming to partially turn it back on.Partial activation ≠ reversal, but it can slow telomere shortening (slowing aging). He believes stronger activators that can win the “tug-of-war” and lengthen telomeres meaningfully could arrive in ~1–3 years if progress continues.Andrews licensed several top nutraceutical fractions that, in his assays, induce telomerase expression modestly and include antioxidants/anti-inflammatories to reduce accelerated shortening.Notable: a turmeric fraction without curcumin (their strongest inducer), plus pomegranate, skullcap root, “gal nut,” and others. No “proprietary blend” label—ingredients are listed individually.He stresses Telo-Vital slows aging; occasional anecdotal reversals (hair/vision/sleep) may occur when tissues have critically short telomeres that are easier to re-lengthen.Do something daily. Consistent, enjoyable endurance-style movement can lower inflammation/oxidative stress; stop before it stops being fun.What can accelerate shortening: frequent senolytics (create gaps → more cell division), high alcohol (liver turnover), growth-hormone/“immune boosters” that drive cell division, and chronic inflammation/oxidative stress.What helps slow acceleration: anti-inflammatory/antioxidant strategies, better glucose control (he mentions a product that “converts sugar to fiber”), mitochondrial support like urolithin A and NAD/Niagen (NR).Product: Telo-Vital (Touchstone Essentials) — site: thegoodinside.comDr. Andrews (science questions): BAndrews@SierraSci.comHe can share recommended YouTube talks on telomeres/telomerase and aging.Bottom line: Telomere shortening is a central, measurable driver of aging. Today's tools may slow that process; Andrews is racing to make meaningful lengthening practical next.If you're interested in online personal training or being a guest on my podcast, "Over 40 Fitness Hacks," you can reach me at brad@over40fitnesshacks.com or visit my website at:www.Over40FitnessHacks.comAdditionally, check out my Yelp reviews for my local business, Evolve Gym in Huntington Beach, at https://bit.ly/3GCKRzV

From childhood curiosity and early passions to her son's life-changing diagnosis, Liz shares the deeply personal journey that turned her into one of the most daring figures in longevity science — even becoming the first human to test her own gene therapy.Together, Len and Liz dive into:The truth about telomeres, stem cells, and the hallmarks of agingHow AAV gene therapy could rewrite the human lifespanThe clash between innovation, regulation, and Big PharmaWhy mental health, music, and creativity are essential to longevityAnd what the future of aging gracefully — or not at all — might look likeBy the end, you'll be questioning what it really means to live a long life… and whether immortality is closer than we think.  EndoDNA: Where Genetic Science Meets Actionable Patient CareEndoDNA bridges the gap between complex genomics and patient wellness. Our patented DNA analysis platforms and AI technology provide genetic insights that support and enhance your clinical expertise.Click here to check out to take control over your Personal Health & Wellness Connect with EndoDNA on SOCIAL: IG | X | YOUTUBE | FBConnect with host, Len May, on IG Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Send us a textHey friend — can we talk about the badge of busyness for a minute?That invisible medal we wear to prove our worth?In medicine, we've turned endurance into identity. We work through exhaustion, chart through dinner, and treat rest like a reward we haven't quite earned. But that constant hustle for worthiness isn't just costing us our joy — it's literally aging us faster.In this 200th episode of Ending Physician Overwhelm, we're diving into the science of stress, telomeres, and how chronic overload is changing our bodies — and more importantly, how we can start to change it back.You'll learn:Why the “cortisol swamp” of modern medicine is eroding our health and energyHow telomeres hold the key to cellular aging (and why chronic stress shortens them)What's changed in medicine that keeps our responsibility high but our control lowHow to stop blaming yourself for existing in chronic stress — and start paying down your “stress debt”And, we're kicking off the 10-Week Recharge Challenge — a series of small, science-backed weekly practices to help you lower stress and rebuild energy.This week's focus: Yoga Nidra — the guided “yogic sleep” practice proven to decrease cortisol and improve rest.Because feeling better isn't a luxury. It's your prescription for longevity, clarity, and peace.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this “Ask Me Anything” (AMA) episode, Peter revisits the “proven, promising, fuzzy, noise, nonsense” scale and applies it to a variety of popular topics. He begins with a refresher on what each category represents before classifying a range of interventions based on the strength of their supporting evidence. The conversation spans three main areas: drugs for geroprotection (including GLP-1 receptor agonists, SGLT2 inhibitors, methylene blue, and telomere-lengthening supplements), the use of low-dose aspirin for cardiovascular disease prevention, and strategies to improve muscle mass through optimal protein intake and follistatin gene therapy. This episode provides a clear, evidence-based overview for listeners seeking to understand where these popular health and longevity interventions stand on the spectrum of scientific credibility. If you're not a subscriber and are listening on a podcast player, you'll only be able to hear a preview of the AMA. If you're a subscriber, you can now listen to this full episode on your private RSS feed or our website at the AMA #76 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here. We discuss: A scale for evaluating scientific claims: proven, promising, fuzzy, noise, or nonsense [1:30]; Strong convictions, loosely held: the mindset that separates great scientists from the rest [7:30]; GLP-1 receptor agonists: are there benefits beyond improving metabolic health and promoting weight loss? [12:45]; GLP-1 drugs and the brain: exploring the potential cognitive benefits [18:45]; GLP-1 drugs and lifespan: examining the evidence for potential geroprotective effects [23:00]; Rapamycin and geroprotection: why it remains in the “promising” category [25:45]; SGLT2 inhibitors and their potential geroprotective effect [27:30]; Methylene blue: examining the evidence of an anti-aging effect [34:45]; Methylene blue's potential neuroprotective effects: limited and inconsistent evidence in humans, and the challenges of dosing and safety [41:15]; Telomeres: what they are, how they relate to aging, and why telomere-lengthening supplements lack credible scientific evidence [43:45]; Does the idea of targeting telomere length to extend lifespan have scientific merit? [50:15]; Low-dose aspirin for cardiovascular disease prevention: weighing its clot-prevention benefits against bleeding risks across different populations [55:00]; Rethinking the protein RDA: why most people need twice the recommended amount for muscle health [1:00:45]; Debunking the protein–cancer myth: why higher protein intake doesn't promote tumor growth [1:06:15]; The biology of follistatin and myostatin, and why follistatin gene therapy has become an emerging topic of interest for muscle growth [1:13:15]; Follistatin gene therapy for muscle growth: state of the evidence in animals and humans, and the technical challenges and regulatory barriers [1:17:00]; Why injectable follistatin is theoretically possible but impractical for real-world use [1:23:15]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

What if the key to slowing down aging was already coded into your DNA?In this episode of The Aging Well Podcast, Dr. Jeff Armstrong welcomes molecular geneticist and longevity innovator Dr. Bill Andrews, Ph.D.—a leading voice in anti-aging research and the man behind the discovery of human telomerase. With more than 50 patents and decades of work at the forefront of genetic science, Dr. Andrews offers clear, evidence-based insights into how cellular aging works, why telomeres matter, and what we can do to support long-term health at the deepest level.This conversation connects the dots between genetics, lifestyle, and the promise of practical longevity—helping you chart a path toward aging well.Learn more about Dr. Andrews: https://sierrasci.com/dr-bill-andrews/Telo-Vital (Touchstone Essentials): https://thegoodinside.com/shop/product/telo-vitalPlease, support The Aging Well Podcast by hitting the ‘like' button, subscribing/following the podcast, sharing with a friend, and….BUY the products you need to… age well from our trusted affiliates and support the mission of The Aging Well Podcast*.The Aging Well Podcast merchandise | Show how you are aging well | Use the promo code AGING WELL for free shipping on orders over $75 | https://theagingwellpodcast-shop.fourthwall.com/promo/AGINGWELLRebalance Health | products created by hormone health experts to lower cortisol, improve sleep, and minimize the impact of stress on the body and mind | https://get.aspr.app/SH1AkZ or https://rebalancehealth.com with the promo code: AGING WELLAuro Wellness | Glutaryl—Antioxidant spray that delivers high doses of glutathione (“Master Antioxidant”) | 10% off Code: AGINGWELL at https://aurowellness.com/agingwellpodcastBerkeley Life | Optimize nitric oxide levels | Purchase your starter kit at a 15% discount | Use the promo code: AGINGWELL15 | https://berkeleylife.pxf.io/c/6475525/3226696/31118Oxford Healthspan | Primeadine®, a plant-derived spermidine supplement | 10% off code: AGINGWELL | https://oxford-healthspan.myshopify.com/AgingWellJigsaw Health | Trusted supplements. “It's fun to feel good.” | Click the following link for 10% off: https://www.jigsawhealth.com/?rfsn=8710089.1dddcf3&utm_source=refersion&utm_medium=affiliate&utm_campaign=8710089.1dddcf3Prolon | The Fasting Mimicking Diet (FMD) is a revolutionary five-day nutrition program scientifically formulated to mimic the effects of a prolonged water fast while still allowing nourishment - supporting the benefits of fasting without the challenges and risks that come from water-only fasts. | For the best available discount always use this link: https://prolonlife.com/theagingwellpodcastL-Nutra Health | The medical division of L-Nutra, focused on helping people manage and potentially reverse chronic health conditions, like type 2 diabetes, prediabetes, insulin resistance, and obesity, using personalized, lifestyle-based programs grounded in evidence, not prescriptions. | Use this link: https://l-nutrahealth.com/theagingwellpodcastThrive25—Your personal longevity advisor | https://www.thrive25.com/early-access?via=william-jeffreyFusionary Formulas | Combining Ayurvedic wisdom with Western science for optimal health support. | 15% off Code: AGINGWELL | https://fusionaryformulas.com?sca_ref=9678325.IHg5xYhdOzzke8ZrDr Lewis Nutrition | Fight neurodegeneration and cognitive decline with Daily Brain Care by Dr Lewis Nutrition—a proven daily formula designed to protect and restore brain function. | 10% off code: AGINGWELL or use the link: https://drlewisnutrition.com/AGINGWELLTruDiagnostic—Your source for epigenetic testing | 12% off Code: AGEWELL or use the link: https://shop.trudiagnostic.com/discount/AGEWELL*We receive commission on these purchases. Thank you.

Chapters: 00:00 Intro – Curing Aging: Science or Science Fiction?01:10 How a Father's Challenge Sparked a Lifetime Mission03:30 Why Aging Might Be a Disease06:00 Evolution & the Purpose of Aging08:30 The Discovery of Telomerase13:00 Ride-Ticket Analogy: Why Cells Stop Dividing17:30 What Telomeres Are & Why They Shorten20:00 How Telomerase Reverses Cellular Aging24:00 Lifestyle Habits that Accelerate Aging28:00 Vegan Diet, Oils, and Longevity Myths31:00 Omega-3s & Vitamin D for Telomere Health33:00 Exercise, Sugar, and Oxidative Stress38:00 Why Too Much Training Can Age You Faster41:00 Gene Therapy & Nanotech in Aging Research46:00 The Promise and Risk of Viruses in Gene Therapy49:00 Can We Live Past 125 Years?52:00 Introducing TeloVital – Plant-Based Telomerase Activator58:00 Telomeres vs DNA Methylation & Horvath Clock1:02:00 Senolytics and Why They Might Be Dangerous1:05:00 Why It's Never Too Late to Start Slowing Aging1:10:00 AI, Machine Learning & the Future of Longevity1:14:00 The Business of Curing Aging & Investor Challenges1:18:00 Best Choice Medicine & FDA Change1:22:00 Plant Medicine, Stress & Cancer Therapies1:27:00 Music Break: The Doors, Taylor Swift & BTS EndoDNA: Where Genetic Science Meets Actionable Patient CareEndoDNA bridges the gap between complex genomics and patient wellness. Our patented DNA analysis platforms and AI technology provide genetic insights that support and enhance your clinical expertise.Click here to check out to take control over your Personal Health & Wellness Connect with EndoDNA on SOCIAL: IG | X | YOUTUBE | FBConnect with host, Len May, on IG Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

“The Evolution of Cancer and Ageing: A History of Constraint” (Nature Reviews Cancer). Fascinating perspective on how tumour suppression mechanisms that protect us early in life may ironically fuel age-related decline later on. ⚖️   From telomeres

In this episode, Dr. Bill Andrews joins Dr. Buck Joffrey to discuss the critical role of telomeres and telomerase in aging and cellular health. He explains how telomeres shorten with each cell division, leading to aging and cellular senescence. Dr. Andrews emphasizes the importance of inducing telomerase to potentially reverse aging and shares insights from his research on telomerase inducers. He also addresses the challenges in longevity research, the relationship between telomeres and the hallmarks of aging, and the potential of gene therapy. The conversation concludes with a discussion on lifestyle factors that can influence aging and the future of aging research. Learn more about Dr. Bill Andrews: https://sierrasci.com/dr-bill-andrews/ - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/

Send us a textAging, tissue repair, and the longevity benefits of psilocin.Episode Summary: Dr. Louise Hecker discusses her research on tissue repair and regeneration, explaining how fibroblasts drive wound healing by forming scar tissue but fail to resolve properly with age, leading to fibrotic diseases like pulmonary fibrosis and liver cirrhosis; they discuss aging hallmarks such as oxidative stress and telomere shortening, and highlight Hecker's study showing psilocybin's active metabolite, psilocin, extends cellular lifespan in lab cultures by reducing oxidants and preserving telomeres, while monthly doses in aged mice improved appearance and survival rates.About the guest: Louise Hecker, PhD is an Associate Professor of Medicine at Baylor College of Medicine, specializing in repair and regeneration processes, particularly in aging and fibrotic diseases.Discussion Points:Fibroblasts are dormant cells that activate during injury to pull wounds closed and form scars, then de-differentiate or die; aging impairs this, causing persistent scarring and disease.Aging reduces the body's regenerative capacity; different organs vary in repair efficiency, with skin healing better than heart tissue.Oxidative stress, like "rust" in the body, accumulates with age due to imbalanced reactive oxygen species production and antioxidant defenses, contributing to cellular damage.Telomeres act as protective DNA caps that shorten with cell divisions, serving as a hallmark of biological aging; sirtuins are master regulators influencing aging processes.Hecker's in vitro study showed psilocin dose-dependently extended fibroblast lifespan by 29-50%, lowering oxidative stress below young cell levels and preserving telomeres.In aged mice (equivalent to 60-65 human years), monthly high-dose psilocybin (15 mg/kg) led to healthier appearance, regrown fur, and 80% survival when controls reached 50% mortality after 10 months.Psilocybin's effects may stem from serotonin receptors expressed in many cell types beyond the brain, suggesting broader anti-aging potential; future work explores mechanisms, optimal dosing, and applications for age-related diseases.Fungi like magic mushrooms represent an under-explored "kingdom" for medicine, with psilocybin's durable effects hinting at systemic impacts on aging.Reference Paper:Study: Psilocybin treatment extends cellular lifespan and improves survival of aged miceRelated content:Support the showAffiliates: Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. For all the ways you can support my efforts

Deepak Srivastava, MD, explores how cellular reprogramming offers new hope for treating heart disease. He highlights innovative strategies to regenerate damaged heart tissue by stimulating adult cardiomyocytes to divide and converting fibroblasts into heart-like cells. His team develops a nonviral delivery system using lipid nanoparticles and investigates the role of specific gene regulators in restoring heart function in animal models. Srivastava also discusses a potential oral therapy for aortic valve disease, driven by insights into cellular fate changes caused by NOTCH1 mutations and telomere shortening. Additionally, he reveals how trisomy 21 may trigger congenital heart defects by altering the identity of specialized heart cells. Through pioneering research in genetics and regenerative medicine, Srivastava demonstrates how understanding developmental biology can lead to transformative clinical advances. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40447]

Deepak Srivastava, MD, explores how cellular reprogramming offers new hope for treating heart disease. He highlights innovative strategies to regenerate damaged heart tissue by stimulating adult cardiomyocytes to divide and converting fibroblasts into heart-like cells. His team develops a nonviral delivery system using lipid nanoparticles and investigates the role of specific gene regulators in restoring heart function in animal models. Srivastava also discusses a potential oral therapy for aortic valve disease, driven by insights into cellular fate changes caused by NOTCH1 mutations and telomere shortening. Additionally, he reveals how trisomy 21 may trigger congenital heart defects by altering the identity of specialized heart cells. Through pioneering research in genetics and regenerative medicine, Srivastava demonstrates how understanding developmental biology can lead to transformative clinical advances. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40447]

Deepak Srivastava, MD, explores how cellular reprogramming offers new hope for treating heart disease. He highlights innovative strategies to regenerate damaged heart tissue by stimulating adult cardiomyocytes to divide and converting fibroblasts into heart-like cells. His team develops a nonviral delivery system using lipid nanoparticles and investigates the role of specific gene regulators in restoring heart function in animal models. Srivastava also discusses a potential oral therapy for aortic valve disease, driven by insights into cellular fate changes caused by NOTCH1 mutations and telomere shortening. Additionally, he reveals how trisomy 21 may trigger congenital heart defects by altering the identity of specialized heart cells. Through pioneering research in genetics and regenerative medicine, Srivastava demonstrates how understanding developmental biology can lead to transformative clinical advances. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40447]

Deepak Srivastava, MD, explores how cellular reprogramming offers new hope for treating heart disease. He highlights innovative strategies to regenerate damaged heart tissue by stimulating adult cardiomyocytes to divide and converting fibroblasts into heart-like cells. His team develops a nonviral delivery system using lipid nanoparticles and investigates the role of specific gene regulators in restoring heart function in animal models. Srivastava also discusses a potential oral therapy for aortic valve disease, driven by insights into cellular fate changes caused by NOTCH1 mutations and telomere shortening. Additionally, he reveals how trisomy 21 may trigger congenital heart defects by altering the identity of specialized heart cells. Through pioneering research in genetics and regenerative medicine, Srivastava demonstrates how understanding developmental biology can lead to transformative clinical advances. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40447]

I'm thrilled to bring you Dave Pascoe—a former network security architect turned longevity athlete and biohacker—whose measured approach to anti‑aging is both rigorous and refreshingly practical. We trace Dave's journey from teenage hacker to data‑driven health optimizer, the telomere wake‑up call that shifted his mindset, and how he now tracks biological age with epigenetic testing (including the DunedinPACE “pace of aging” algorithm popularized by TrueDiagnostic). We also unpack the Rejuvenation Olympics—what the leaderboard actually measures and how to think about it without the hype. If you've heard buzzwords like “pace of aging” and wondered what they really mean, we translate them into plain English here. From there we get tactical: why Dave cut out ultra‑processed foods (we touch on the NOVA classification so you can spot them fast), how he reframed running and training, and why VO₂ max is one of the strongest fitness predictors of longevity. We compare sprint work vs. endurance for healthspan, dive into SHBG and testosterone (and why carbs, stress, and training load matter), and talk sleep, meditation, and the often‑ignored lymphatic system—including why movement is non‑negotiable because your lymph relies on muscle contraction to flow. Expect clear takeaways you can apply this week: food upgrades, training levers, recovery basics, and lab markers that actually move the needle. Finally, we open the hood on Dave's AI‑driven supplement schedule—how he used large language models to de‑conflict ~100+ ingredients into practical AM/PM dosing, and why he's building a personal GPT that ingests labs, wearables, and genetics for personalized protocols. We also level‑set on gene‑therapy hype, “exercise in a pill,” and influencer blueprints versus fundamentals. The mantra we land on is simple: “Comfort is good, capability is better.” Listen in for the frameworks, the mistakes to avoid, and a preview of Part 2, where we'll walk through Dave's public playbook so you can build your own. 

In this episode of the Gladden Longevity Podcast, Dr. Jeffrey Gladden and Dr. Aimie Apigian delve into the intricate relationship between trauma, healing, and the body's response to stress. They explore how trauma is imprinted in the nervous system and tissues, the importance of movement and agency in overcoming trauma, and the biological mechanisms that underpin these experiences. Through personal stories and scientific insights, they discuss the role of energy in healing, the impact of childhood experiences, and the potential for reframing traumatic events to regain control and foster resilience. This conversation offers valuable perspectives on navigating the complexities of trauma and the path to recovery.   For Audience ·       Use code 'Podcast10' to get 10% OFF on any of our supplements at https://gladdenlongevityshop.com/ !    Takeaways ·       Trauma is imprinted in the nervous system and tissues of the body. ·       Understanding one's own trauma can lead to healing and growth. ·       The biology of trauma involves energy conservation and stress responses. ·       Movement and agency are crucial in overcoming trauma. ·       Reframing traumatic experiences can help regain a sense of control. ·       The impact of childhood experiences shapes adult responses to stress. ·       Somatic experiences can help reprogram trauma responses. ·       Energy levels are linked to trauma responses and mental health. ·       The nervous system's state influences our ability to cope with stress. ·       Healing is possible through understanding and addressing trauma.   Chapters 00:00 Introduction to Trauma and Healing 04:14 The Journey into Foster Parenting 07:13 Understanding Trauma Through Personal Experience 10:08 The Biology of Trauma and Its Effects 12:54 Generational Trauma and Its Impact 15:47 Distinguishing Between Stress and Trauma Biology 18:46 The Autonomic Nervous System's Role in Trauma 21:40 Psychological Studies on Trauma Responses 23:20 Understanding Trauma Through Animal Studies 25:27 The Impact of Trauma on Neural Pathways 27:29 Reprogramming the Body's Response to Trauma 28:36 Muscle Memory and Trauma Responses 30:36 The Role of Movement in Healing 32:54 The Limitations of Talk Therapy 36:54 Reframing Trauma and Its Unbearable Nature 43:09 Reframing Trauma as Opportunity 44:56 The Purpose of Life and Authenticity 46:35 Agency and Movement in Healing 49:20 Neurodevelopment and Sense of Agency 52:25 Measuring Agency Through Movement 55:14 Energy as a Key to Overcoming Trauma   To learn more about Dr. Aimie: Email:  aimie_kris@hotmail.com Website: https://biologyoftrauma.com/   Reach out to us at:    Website: https://gladdenlongevity.com/     Facebook: https://www.facebook.com/Gladdenlongevity/    Instagram: https://www.instagram.com/gladdenlongevity/?hl=en     LinkedIn: https://www.linkedin.com/company/gladdenlongevity    YouTube: https://www.youtube.com/channel/UC5_q8nexY4K5ilgFnKm7naw

The world of medicine can be very confusing and hard to navigate. We sit down with Dr. Joe, a toxicologist who is here to help us understand the world of pharmacology. Dr. Joe explores practical, science-backed strategies to increase longevity and improve overall health, including the role of intermittent fasting, telomeres, and inflammation. His insights empower listeners to take control of their well-being and make informed health decisions. He offers assistance to people who have questions about their health and medications.  We also dive into the world of C60, and it's effectiveness at promoting overall health. If after listening to the episode you're interested in trying or supporting Dr Joe you can visit https://livelongerlabs.com/ Use Code DRJOE15 for 15% off your order   Only buy what you need to, use Think Fitness Life's trusted affiliates.  For Physical Assistance Think Fitness Life Coaching is backed by 25 years of Experience guiding people to fitness freedom. Learn more Mention “Kickstart discount” for 10% off your first month.   For Therapy Services we partnered with BetterHelp: A telehealth therapy service connecting people with licensed mental health therapists. Learn more By using the referral link you receive 10% off your first month.     Disclaimer: We're here to share ideas and inspiration, not medical advice. Please check with your doctor before making any changes to your health or fitness routine.  

"Getting old is for the birds.” Have you uttered those words yourself or heard others say that? Do you find yourself talking about your aches, pains, and age-related concerns now more than ever? Your health affects nearly every aspect of life – sleep, mobility, activities of daily living, work, social interactions, finances, and more.Aging well is a lifetime process of healthy choices with diet, lifestyle, exercise, family, friends, and spiritual connections. Add environmental exposures, family genetics, microbiome balance, and much more. Aging is inevitable, but making healthy, insightful choices can enhance your ability to age well. This week George discusses healthspan vs. Lifespan.Dr. Jeff Crippen discusses Fish Oil and surgery. What is the real science?

Today, I'm joined by the trailblazing Liz Parrish, a true pioneer in the world of longevity science and regenerative medicine. Liz doesn't just talk about cutting-edge gene therapies—she's the first patient to actually undergo many of them herself. In our conversation, Liz shares how her journey from stem cell advocacy to biotech innovation was fueled by a deeply personal mission: her son's diagnosis with type 1 diabetes.   What we discuss: How Liz Parrish got into genetics and stem cells ... 00:06:45 Transition from childhood disease to treating aging ... 00:09:35 Difference between stem cells, gene therapy, and exosomes ... 00:14:20 Challenges in gene therapy delivery and cell reprogramming ... 00:19:22 Liz Parrish as patient zero for gene therapies ... 00:22:01 Results and lessons from Parrish's self-experimentation ... 00:23:16 Senescent cells, telomeres, and aging interventions ... 00:29:22 Evolution and progress in gene therapy ... 00:34:14 Barriers and ethics of gene therapy for rare diseases and children ... 00:36:53 Public perception and future accessibility ... 00:44:55 Affordability, scaling, and redosing gene therapies ... 00:55:00 Practical longevity habits and hormones ... 01:03:54   Our Amazing Sponsors: OraltidePro™️by Profound Health - A unique mouthwash that: Promotes growth of shrinking gums, Speeds healing of mouth & tongue, Prevents oral infections (such as gingivitis), helps with enamel remineralization, reduces bacteria growth and etching and fills slots in damaged enamel. Check out OraltidePro™️at profound-health.com and use code NAT15 for 15% off your first order. NMN+G Rx by Wizard Sciences -  A scientifically formulated blend of NMN, ginsenosides from Panax ginseng, and apigenin. Together, they enhance mitochondrial function, boost NAD+ levels, and support cellular repair. Go to wizardsciences.com and look for NMN+G. Use code NAT15 at checkout to get 15% off your purchase. Fresh-Pressed Olive Oil Club: Get a full-size $39 bottle of one of the world's finest artisanal olive oils — fresh from the new harvest—for just $1. No commitment to buy anything, now or ever. Go to GetFreshLongevity.com for a free bottle and pay just $1.   More from Nat:  YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

Why is my B6 so high when I only take a small amount of it?Can nocturia be associated with dehydration?Please weigh in on allulose. Is it too good to be true?My husband's hemoglobin is lower than his previous lab test. Is this a cause for concern? 

Reducing food waste Please share your thoughts concerning controversies about the significance of telomere length

In first-ever study, keto diet scores vs. Parkinson's; Walk away from dementia; Loneliness can kill, but negative social ties can hasten biological aging; Researchers isolate potent memory compound from sage, rosemary; Sketchy knockoff weight loss drugs are flooding the marketplace; The popular vitamin you shouldn't take for sarcoidosis; When osteoporosis is so severe that even minor trauma causes rib fractures.

Renowned anti-aging expert Dr. Bill Andrews rejoins the show for a powerful conversation about the future of aging—and how extending healthspan could radically reshape society. We ask the tough questions:Is it ethical to slow or reverse aging if it means more people live longer? Or is it our responsibility to help those who are suffering in a weakened, isolated, and often overlooked state? Dr. Andrews argues that extending vitality isn't just possible—it's the humane and logical thing to do. We explore what a future might look like where people live longer but stay healthy, active, and mentally sharp. Could extended life bring a new wave of explorers, innovators, and contributors instead of burdens on the system? Plus, we're excited to announce the launch of Telo-Vital—the most promising telomere-lengthening supplement to date, now available at a price accessible to everyday people. This product is the result of years of cutting-edge research and could represent a major breakthrough in real, affordable anti-aging science.You can buy telo-vital for only $39 at https://grow.thegoodinside.com/special-offer-telo-vital-892649-lp

In this episode of Resilience Unraveled, Dr Russell Thackeray chats to Dr. Julian Gershon Jr., a specialist in family medicine, sports medicine, and anti-aging and regenerative medicine, who shares insights from his 45-year career. He discusses his work with stem cell therapy, hormone balancing, and longevity science. The conversation highlights the significance of DNA methylation, telomere length, and how lifestyle choices impact aging. Dr. Gershon covers the benefits of GLP-1, Metformin, and the revolutionary potential of stem cell research. He also introduces his book, 'Beyond the Fountain of Youth,' and emphasizes the importance of self-awareness and proactive health management.00:00 Introduction and Guest Welcome00:38 Dr. Julian Gershon's Background and Expertise01:26 Understanding Longevity and Anti-Aging Medicine03:43 The Role of Telomeres in Aging06:10 The Importance of Diet and Lifestyle12:08 Hormone Balancing and Its Benefits21:36 Stem Cell Research and Its Potential23:02 About the Book: Beyond the Fountain of Youth24:48 Conclusion and Final ThoughtsYou can contact us at info@qedod.comResources can be found online or link to our website https://resilienceunravelled.com

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Tech entrepreneur Dave Asprey once found himself battling chronic fatigue, autoimmunity, and the threat of a stroke - all while climbing the Silicon Valley ladder at 300 pounds. Confronted with life-or-death stakes, he poured millions into biohacking his brain health, metabolism, diet, and sleep to reclaim his energy and sharpen his mindset. In this episode, Dave reveals the science-backed strategies behind fasting, longevity, and peak health that earned him the title “Father of Biohacking,” and that any entrepreneur can use to boost energy, productivity and mental clarity. In this episode, Hala and Dave will discuss: (00:00) Introduction (01:29) Dave Asprey's Early Life and Health Struggles (03:05) From Internet Pioneer to Biohacking Guru (06:24) The Birth of Bulletproof Coffee (09:31) The Philosophy Behind Biohacking (17:21) The Future of Human Longevity (25:40) Preventing and Reversing Alzheimer's (26:46) Dave Asprey's Current Ventures and Closing Thoughts (27:57) Redefining Age: Biological vs. Calendar Years (28:54) Measuring Biological Age: True Age and Telomeres (29:46) Personal Development and Biological Influence (31:15) Anti-Aging Investments and Strategies (32:32) The Power of Intermittent Fasting (35:27) Understanding Fasting: Beyond Food (41:56) Ketosis vs. Autophagy: The Science Explained (45:03) Fasting During Ramadan: Health Insights (49:05) Quick Fire: Different Fasting Methods (51:04) Fasting Differences: Men vs. Women Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof 360, and host of the Webby Award-winning The Human Upgrade Podcast. Recognized globally as the “Father of Biohacking,” Dave is a Silicon Valley veteran who pioneered functional coffee and popularized MCT oil. He also launched Upgrade Labs, the world's first human performance center. Dave has been featured on TODAY, CNN and in The New York Times for his groundbreaking work in brain health, nutrition and longevity. Sponsored By: Indeed - Get a $75 sponsored job credit at ⁠indeed.com/profitingIndeed⁠  Shopify - Sign up for a one-dollar-per-month trial period at ⁠youngandprofiting.co/shopify⁠  Microsoft Teams - Stop paying for tools. Get everything you need, for free at ⁠aka.ms/profiting⁠  Mercury - Streamline your banking and finances in one place. Learn more at ⁠mercury.com/profiting⁠  LinkedIn Marketing Solutions - Get a $100 credit on your next campaign at ⁠linkedin.com/profiting⁠   Bilt - Start paying rent through Bilt and take advantage of your Neighborhood Benefits™ by going to ⁠joinbilt.com/PROFITING⁠.  Airbnb - Find yourself a co-host at ⁠airbnb.com/host⁠  Resources Mentioned: Dave's Book: Fast This Way: https://www.amazon.com/Fast-This-Way-Inflammation-High-Performing/dp/0062882864  Dave's Website & Upgrade Collective: daveasprey.comDave's Podcast, The Human Upgrade: https://bit.ly/THU-apple Active Deals - youngandprofiting.com/deals       Key YAP Links Reviews - ratethispodcast.com/yap  Youtube - youtube.com/c/YoungandProfiting  LinkedIn - linkedin.com/in/htaha/  Instagram - instagram.com/yapwithhala/  Social + Podcast Services - yapmedia.com   Transcripts - youngandprofiting.com/episodes-new  Entrepreneurship, entrepreneurship podcast, Business, Business podcast, Self Improvement, Self-Improvement, Personal development, Starting a business, Strategy, Investing, Sales, Selling, Psychology, Productivity, Entrepreneurs, AI, Artificial Intelligence, Technology, Marketing, Negotiation, Money, Finance, Side hustle, Startup, Career, Leadership, Mindset, Health, Growth mindset, Mental Health, Health, Psychology, Wellness, Biohacking, Motivation, Mindset, Manifestation, Brain Health, Life Balance, Self-Healing, Positivity, Happiness, Sleep, Diet

In this episode, Dr. Terry Wahls joins Dr. Jockers to discuss how lifestyle choices directly impact telomere health and slow aging. You'll learn how diet, exercise, and stress management can reverse biological aging, helping you feel younger and more vibrant.   The episode explores the significance of telomeres as a measure of biological age and how chronic inflammation and oxidative stress contribute to accelerated aging. Dr. Wahls shares valuable insights on how lifestyle changes can mitigate these factors.   Dr. Jockers and Dr. Wahls also dive into practical strategies for improving telomere health, including fasting, ketogenic eating, and exposure to red light therapy. These approaches can enhance your body's ability to repair itself and boost overall longevity.   In This Episode: 00:00 Introduction to Functional Nutrition 05:33 Interview with Dr. Terry Walls: Telomeres and Longevity 10:02 Dr. Terry Walls' Personal Journey with MS 12:55 The Power of Diet and Lifestyle in Healing 23:06 Future of Personalized Medicine 24:36 Personalized Diet Plans 27:16 The Importance of Stomach Acid 30:07 Behavior Change and Functional Medicine 32:35 Exercise and Recovery 42:15 Daily Routine for Optimal Health 47:18 Final Thoughts and Gratitude   Did you know collagen production declines as you age? Boost your body's collagen with Paleovalley Bone Broth Protein, made from 100% grass-fed beef bones. It supports healthy skin, joints, and digestion in just 30 seconds a day. No time to simmer bones? No problem! Simply mix the protein powder with hot water or add it to smoothies. Get yours today at paleovalley.com/drjockers and use code JOCKERS to save 15%!   Struggling with digestion? Just Thrive Digestive Bitters help stimulate the production of stomach acid, bile, and pancreatic enzymes, improving digestion, easing bloating, and enhancing nutrient absorption. It's the natural way to support your gut health and feel better after every meal. Visit justthrivehealth.com and use code JOCKERS to save 20% off your order!   This episode is brought to you by Vibrant Blue Oils. If you want to enhance your body's natural healing abilities, try their Parasympathetic Essential Oil Blend. This non-invasive oil helps calm stress, reduce inflammation, and improve digestion, detoxification, and immune function. Start feeling fantastic today by visiting vibrantblueoils.com/jockers and grab your $15 full-size bottle of the Parasympathetic Blend.   Experience a new efficiency level with Freed AI, the AI medical scribe that transforms how healthcare professionals manage documentation. It listens, transcribes, and finalizes clinical notes instantly, perfect for both in-office and virtual visits across all specialties. HIPAA-compliant and incredibly user-friendly, Freed AI lets you reclaim hours each day, allowing you to focus more on your patients. Start your free trial today—no credit card is needed. For my listeners, use promo code Jockers50 for 50% off your first month when you subscribe. Learn more at getfreed.ai.     "You have the power to influence your biological age through the right nutrition, exercise, and stress management." ~ Dr. Jockers     Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean  TuneIn Radio     Resources: Paleovalley - visit paleovalley.com/jockers Visit justthrivehealth.com and use code Jockers for a 20% discount Visit https://vibrantblueoils.com/jockers Visit getfreed.ai.     Connect with Dr. Terry Wahls: Website - https://terrywahls.com/ Book - https://amzn.to/3Fma1op     Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https://www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/   If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/