Podcasts about igf

What Causes Cancer? The Truth Most Doctors Don't Talk AboutIn this episode of Intellectual Medicine, Dr. Stephen Petteruti explores the relationship between cancer, metabolism, sugar, insulin, body fat, and prostate cancer progression. He discusses the Warburg theory, which suggests that cancer may begin with dysfunctional mitochondrial metabolism, and compares it with the later focus on genetic causes of cancer. While he argues that the idea of “starving cancer” by eliminating sugar is too simplistic, he also emphasizes that metabolic health plays a real role in cancer risk and progression.The episode focuses heavily on prostate cancer, which Dr. Petteruti describes as unique compared with other cancers. He argues that conventional approaches often overlook the environment in which cancer develops, including excess body fat, high insulin, elevated blood sugar, inflammation, and poor metabolic health. He also discusses tests such as fasting insulin, hemoglobin A1c, and continuous glucose monitoring, as well as the importance of nutritional and behavioral change. The episode closes with a warning against extreme diets, oversimplified supplement advice, and one-size-fits-all cancer theories.Timestamps:(00:00) What Causes Cancer?(01:02 )The Warburg Theory(02:14) Genetics vs. Metabolism(04:22) Why “Starving Cancer” Is Too Simplistic(05:42) Body Fat, Insulin, and Prostate Cancer(08:30) Tests That May Help Assess Metabolic Health(10:47) Food, Weight Loss, and Cancer Risk(13:42) The Anti-Cancer Lifestyle(15:04) Toxins, Viruses, and Parasites(16:15) NAD, Mitochondria, and Supplement Caution(17:33) Growth Hormone, IGF-1, and Cancer Risk(19:12) Why Extreme Dieting Is Not the AnswerEnjoy the podcast? Subscribe and leave a 5-star review on your favorite platforms.Dr. Stephen Petteruti is a board-certified physician specializing in longevity-focused, integrative medicine. He works with men navigating prostate cancer, testosterone, and hormone health, aging, and performance using proactive, evidence-informed strategies grounded in real clinical practice. His approach prioritizes preserving function, strength, and quality of life while helping patients make clear, informed decisions beyond reactive, fear-driven care.Book: Fight Cancer Like a Man: https://tinyurl.com/FightLikeAManBookDr. Steve's email newsletter: https://drstephenpetteruti.substack.com/subscribePodcast show notes : https://www.intellectualmedicine.com/podcast-notesMember exclusive content: https://tinyurl.com/DrPetterutiMemberLearn more: https://www.drstephenpetteruti.com/ Learn more: https://www.intellectualmedicine.com/ Connect with Dr. Petteruti on:⁠Instagram: ⁠https://www.instagram.com/dr.stephenpetteruti/⁠ Facebook: ⁠https://www.facebook.com/dr.stephenpetteruti⁠ Disclaimer:The content presented in this video reflects the opinions and clinical experience of Dr. Stephen Petteruti and is intended for informational and educational purposes only. It is not medical advice and should not be used as a substitute for professional diagnosis, treatment, or guidance from your personal healthcare provider. Always consult your physician or qualified healthcare professional before making any changes to your health regimen or treatment plan.

Dr. Kassam explains how hormones, IGF-1, nitrates, and saturated fat in dairy and meat promote cancer growth and DNA damage. #CancerRiskFactors #DairyAndCancer #MeatAndCancer #NutritionMechanisms

Explore how IGF-1, saturated fat, and keto diets can fuel cancer growth, while plant-based diets offer protection. #CancerRisk #KetoMyths #IGF1 #PlantProtection

Your body after a baby was never a calorie problem. It is a metabolic one. In this Her Stack episode I am walking you through exactly how to restore your metabolism so body composition follows. The goal is not weight loss. The goal is metabolic restoration. Body comp is downstream. I am breaking down the four drivers that actually run body composition (insulin, thyroid, sleep, growth hormone), the four pillars to address them (nutrition, lifestyle, supplements, peptides), and the exact peptide sequencing for women. Plus my honest take on GLP-1s including semaglutide, tirzepatide, and retatrutide, where they actually fit, and why microdosing makes more sense than chasing the scale. I also share what nobody talks about. Eating less postpartum often makes body composition worse. Breastfeeding is sequencing, not failure. Growth hormone is the layer women never hear about, so they plateau and blame their age when it was a fixable signal the whole time. Join The LongHer Life for women-specific guidance on peptides, hormones, and longevity.   I TALK ABOUT: 00:00 Welcome back to the Her Stack series 00:53 Updates: working with me one-on-one and my new peptide planner 06:15 Why body composition not weight, and why metabolism not calories 07:01 The four drivers and four pillars framework 09:00 Driver 1: Insulin resistance and why stubborn middle fat is an insulin problem, not a calorie problem 11:30 Driver 2: Thyroid, and why TSH alone misses Free T3 (the worker hormone) 14:50 Driver 3: Sleep, cortisol, and the loop back to insulin resistance 19:32 Driver 4: Growth hormone, the layer nobody talks about that's blunted postpartum and through aging 22:19 The labs to actually ask for: fasting insulin, Free T3, IGF-1, DHEA-S, plus a 2-week CGM 24:30 Pillar 1: Nutrition (protein floor of 120g, leucine at every meal, food order, fiber, and why you should NOT under-eat) 28:06 Why leucine flips the muscle-building switch 35:00 Pillar 2: Lifestyle and biohacking (lift 3x a week, walk 7-10k steps, zone 2, cold and heat, red light, and the fringe tier honestly) 45:30 Pillar 3: Supplements (creatine, magnesium glycinate, myo-inositol, omega-3, berberine, and breastfeeding sequencing) 51:01 Berberine, AMPK, and "nature's metformin" 55:30 Pillar 4: The peptide stack starts here with AOD-9604 56:00 AOD-9604, the growth hormone fragment, why I am personally taking it right now 01:02:00 MOTS-c, the "exercise in a molecule" mitochondrial peptide 01:05:00 5-Amino-1MQ and releasing the brake on fat cells 01:07:00 Sermorelin, the gentle GH entry (what a secretagogue actually is) 01:10:00 CJC-1295, Ipamorelin, and Tesamorelin for post-weaning GH restoration 01:13:00 The GLP-1 honest take: semaglutide, tirzepatide, and the retatrutide question 01:14:00 Why retatrutide is called the triple agonist and where it fits (and where it doesn't) 01:19:27 Recap and wrap-up   RESOURCES: Work with me one-on-one on your peptide stack and protocol. The Her Stack Planner, the first peptide tracking journal built around female biology. Free Peptide Masterclass for Women. Join The LongHer Life for women-specific guidance on peptides, hormones, and longevity.   LET'S CONNECT: Instagram, TikTok, Facebook Shop my favorite health products Listen on Spotify, Apple Podcasts, YouTube Music

Go to NutronicsLabs.com for 50% off with autoship + a FREE platinum bottle of IGF-1. Use code “MELK” for an extra 10% off!   We The People must stand strong, stay united, resolute, calm, and focus on the mission. Order Mel's New Book: Americans Anonymous: Restoring Power to the People One Citizen at a Time https://themelkshow.com/book The Show's Partners Page: https://themelkshow.com/partners/ Consider Making A Donation: https://themelkshow.com/donate/ Beverly Hills Precious Metals Exchange - Buy Gold & Silver https://themelkshow.com/gold/ Speak with Gold Expert Andrew Sorchini…Tell Him Mel K Sent You! Dr. Zelenko Immunity Protocols https://zstacklife.com/MelK I trust SatellitePhoneStore when all other networks fail. With their phone, I know I'm always connected, no matter where I am or what happens. https://sat123.com/melk/ I've tried a lot of supplements over the years, but nothing has compared to the purity and results I've experienced with Chemical Free Body. USE CODE MELK Mel K Superfoods Supercharge your wellness with Mel K Superfoods Use Code: MELKWELLNESS and Save Over $100 off retail today! https://themelkshow.com/partners/ Healthy Hydration: https://themelkshow.com/partners/ Patriot Mobile Support your values, your freedom and the Mel K Show. Switch to Patriot Mobile for Free. Use free activation code MELK https://themelkshow.com/partners/ HempWorx The #1 selling CBD brand. Offering cutting edge products that run the gamut from CBD oils and other hemp products to essential oils in our Mantra Brand, MDC Daily Sprays which are Vitamin and Herb combination sprays/ https://themelkshow.com/partners/ Dr. Zelenko Immunity Protocols https://zstacklife.com/MelK Support Patriots With MyPillow Go to https://www.mypillow.com/melk Use offer code “MelK” to support both MyPillow and The Mel K Show The Wellness Company - Emergency Medical Kits: https://themelkshow.com/partners/ Dr. Stella Immanuel, MD. Consult with a renowned healthcare provider! Offering Telehealth Services & Supplements. Use offer code ‘MelK' for 5% Off https://themelkshow.com/partners/ Rumble (Video) - The Mel K Show: https://rumble.com/c/TheMelKShow X: https://twitter.com/MelKShow Twitter (Original): https://twitter.com/originalmelk TRUTH Social: https://truthsocial.com/@themelkshow Instagram: https://www.instagram.com/themelkshow/ Podbean: https://themelkshow.podbean.com/ GETTR: https://www.gettr.com/user/themelkshow Locals.com: https://melk.locals.com/ Banned Video: https://banned.video/channel/the-mel-k-show We at www.themelkshow.com want to thank all our amazing patriot pals for joining us on this journey, for your support of our work, and for your faith in this biblical transition to greatness. Together we are unstoppable. We look forward to seeing you. God Wins! https://themelkshow.com/events/ Remember to mention Mel K for great discounts on all these fun and informative events. See you there! Our Website www.TheMelKShow.com We love what we do and are working hard to keep on top of everything to help this transition along peacefully and with love. Please help us amplify our message: Like, Comment & Share!

Go to NutronicsLabs.com for 50% off with autoship + a FREE platinum bottle of IGF-1. Use code “MELK” for an extra 10% off!   We The People must stand strong, stay united, resolute, calm, and focus on the mission. Order Mel's New Book: Americans Anonymous: Restoring Power to the People One Citizen at a Time https://themelkshow.com/book The Show's Partners Page: https://themelkshow.com/partners/ Consider Making A Donation: https://themelkshow.com/donate/ Beverly Hills Precious Metals Exchange - Buy Gold & Silver https://themelkshow.com/gold/ Speak with Gold Expert Andrew Sorchini…Tell Him Mel K Sent You! Dr. Zelenko Immunity Protocols https://zstacklife.com/MelK I trust SatellitePhoneStore when all other networks fail. With their phone, I know I'm always connected, no matter where I am or what happens. https://sat123.com/melk/ I've tried a lot of supplements over the years, but nothing has compared to the purity and results I've experienced with Chemical Free Body. USE CODE MELK Mel K Superfoods Supercharge your wellness with Mel K Superfoods Use Code: MELKWELLNESS and Save Over $100 off retail today! https://themelkshow.com/partners/ Healthy Hydration: https://themelkshow.com/partners/ Patriot Mobile Support your values, your freedom and the Mel K Show. Switch to Patriot Mobile for Free. Use free activation code MELK https://themelkshow.com/partners/ HempWorx The #1 selling CBD brand. Offering cutting edge products that run the gamut from CBD oils and other hemp products to essential oils in our Mantra Brand, MDC Daily Sprays which are Vitamin and Herb combination sprays/ https://themelkshow.com/partners/ Dr. Zelenko Immunity Protocols https://zstacklife.com/MelK Support Patriots With MyPillow Go to https://www.mypillow.com/melk Use offer code “MelK” to support both MyPillow and The Mel K Show The Wellness Company - Emergency Medical Kits: https://themelkshow.com/partners/ Dr. Stella Immanuel, MD. Consult with a renowned healthcare provider! Offering Telehealth Services & Supplements. Use offer code ‘MelK' for 5% Off https://themelkshow.com/partners/ Rumble (Video) - The Mel K Show: https://rumble.com/c/TheMelKShow X: https://twitter.com/MelKShow Twitter (Original): https://twitter.com/originalmelk TRUTH Social: https://truthsocial.com/@themelkshow Instagram: https://www.instagram.com/themelkshow/ Podbean: https://themelkshow.podbean.com/ GETTR: https://www.gettr.com/user/themelkshow Locals.com: https://melk.locals.com/ Banned Video: https://banned.video/channel/the-mel-k-show We at www.themelkshow.com want to thank all our amazing patriot pals for joining us on this journey, for your support of our work, and for your faith in this biblical transition to greatness. Together we are unstoppable. We look forward to seeing you. God Wins! https://themelkshow.com/events/ Remember to mention Mel K for great discounts on all these fun and informative events. See you there! Our Website www.TheMelKShow.com We love what we do and are working hard to keep on top of everything to help this transition along peacefully and with love. Please help us amplify our message: Like, Comment & Share!

Robert Rapaport, MD, Professor of Pediatric Endocrinology, and Director of the Comprehensive Growth Center at the Icahn School of Medicine, Mount Sinai Medical Center, New York City, discusses the causes of growth hormone deficiency and its treatment. Growth failure in children is a considerable challenge for parents and pediatricians, with clinical and social stigma implications that may be avoided with early diagnosis.The most important issue in young patients with growth failure is to detect it early, according to Dr. Rapaport. “As soon as you see a major deviation from the [expected growth chart] norm, act on it, even at age 2,” he emphasized, “because we know that best outcomes result from early detection.” A growth failure diagnosis is delayed or underdiagnosed in minority groups; it is underdiagnosed in girls relative to boys. In most cases, children are referred to the Comprehensive Growth Center by pediatricians and primary care physicians, and it should be monitored from birth. Growth failure in children can be caused by growth hormone (GH) deficiency, malnutrition, celiac disease, pituitary tumor (which suppresses the release of growth hormone) or a very rare genetic deletion. Once the potentially nonendocrine causes of GH deficiency are excluded, then causes related to the hypothalamus–pituitary-thyroid axis should be investigated, said Dr. Rapaport. Growth hormone stimulation testing and low blood levels of insulin-like growth factor (IGF) and IGF-binding protein concentrations can help confirm GH deficiency as the cause. However, low IGF-1 levels can also be caused by excessively high GH levels. In children diagnosed with GH deficiency, weekly GH injections are typically prescribed. In addition to monitoring these children for potential side effects of the GH injections, Dr. Rapoport recommended that they should undergo lab testing for IGF-1 blood concentrations every 3 to 6 months, until the bones fuse (signaling the conclusion of growth).

I tested ProLon, the fasting-mimicking diet, against a 5-day sardine fast, ran my own bloodwork, and got the opposite result I expected. ProLon is the best-known version of the fasting-mimicking diet (FMD), a 5-day, low-calorie, plant-based protocol developed from Dr. Valter Longo's research at USC. The sardine fast is the cheap, unbranded version people keep hyping online. I ran both on myself about a month apart, kept calories low on each, and tracked the same markers throughout: IGF-1, fasting insulin, HOMA-IR, glucose, ketones, and glucose ketone index. I was sure the premium protocol would win. I had spent years studying these pathways and expected the plant-based, low-protein design to be the real driver. A few cans of fish gave me the opposite answer. What you'll see in this podcast:  The exact lab data that flipped my prediction IGF-1 side by side: the FMD dropped mine 55 points, the sardine fast dropped it 88 How the sardine fast drove me into a deeper ketotic state than the $200 kit Where my fasting insulin, HOMA-IR, glucose, ketones, and GKI landed on each protocol A clearer way to understand mTOR and autophagy Why autophagy is not the on-off switch the internet claims Why a little of the right protein may help protect lean muscle during a deficit What this means for clinicians who want metabolic interventions patients can actually afford About: I'm Andrew Reid. I founded Medgeeks in 2013, and for the last five years, I've been rebuilding how I think about chronic disease from the cell up. My goal is to treat nutrition as a real therapeutic intervention, held to the same standard of rigor we expect from pharmaceuticals. Subscribe for nutrition held to a higher standard, with real data and honest answers even when they're inconvenient. Here's everything I'm building → https://medgeeks.co/ Disclaimer: This is an N of 1 experiment on my own physiology, shared for educational purposes only. It is not medical advice. A protocol like this is not right for everyone, especially if you are lean, managing a chronic condition, or taking medication. Talk with your healthcare provider before attempting any form of fasting or significant dietary change. 

In this Q&A episode of the Her Stack Series, I'm answering the peptide questions you're asking me every single day in my DMs and comments:  → Can I take peptides while breastfeeding? → What if I have a personal or family history of cancer? → Why won't my postpartum belly fat budge, even when I'm doing everything "right"? → Blends vs. single peptides, which is right for me? → How do I build my own peptide stack without ending up on eight injections a day? I'm unfiltered in this one. I share why there will never be clinical trials on peptides during breastfeeding (and what that really means for you when you're making the decision), the truth about growth hormone, IGF-1, and theoretical cancer risk, and my honest take on why most peptide advice from men completely misses the mark for women. Join The Mother's Protocol Program for women-specific guidance on peptides, hormones, and longevity. I TALK ABOUT: 00:00 — Welcome + episode intro 00:53 — Doors close Sunday: The Mother's Protocol Program 06:51 — A personal moment: new beginnings 09:07 — Q1: Can I take peptides while breastfeeding? 20:48 — Q2: Do peptides cause cancer? (BPC-157, growth hormone, IGF-1) 26:16 — Q3: Stubborn postpartum weight (MOTS-c, AOD 9604) 30:39 — Q4: Blends vs. single peptides (Glow, Wolverine, CJC/Ipamorelin) 33:46 — Q5: How to build your own peptide stack 39:14 — Wrap-up RESOURCES: — The Mother's Protocol Program: my 12-week group program for women + mothers. Doors close Sunday, we start Monday June 8. — Her Stack Planner: my peptide planner for women. Digital available now, physical coming this summer. — Free Peptide Masterclass replay — available until Sunday. CONNECT: Instagram: @biohackingbrittany Website: biohackingbrittany.com Next week on the Her Stack Series I'm going deep on body composition — every peptide for weight loss, the nutrition + exercise foundation, and what actually works postpartum, perimenopause, and menopause.

Learn about the Healing Power of Prolonged Fasting: HEREWhat if the one food you've been told to avoid isn't always the problem, and when prepared the right way, could actually support your healing?In this episode, Dr. Katie Deming brings back Monica Corrado, a traditional foods educator, author, and ancestral nutrition expert to dig into what's actually true about dairy, cancer, and the gut.They break down the difference between the dairy you'll find on grocery store shelves and the kind traditional cultures prepared for centuries. They cover everything from Holstein cows versus traditional brown cows, to A1 versus A2 casein, to why raw milk dairies may be held to stricter safety standards than conventional pasteurized dairy.You'll also find out why some people feel sick after trying raw milk for the first time, and why that reaction may have more to do with drinking too much of a potent, microbially live food too quickly than with the milk itself.Chapters:00:06:08 - Why Modern Dairy Changed00:07:18 - The Problem With Store Dairy00:08:24 - The Dairy That May Heal00:09:12 - The Raw Milk Difference00:10:05 - How Culturing Removes Sugar00:11:18 - Why Raw Milk Scares People00:15:21 - How Milk Quality Got Lost00:18:11 - Drinking Dead Bacteria00:20:29 - A1 vs A2 Dairy00:24:19 - What Better Dairy Looks Like00:26:09 - Making Dairy Cancer Friendly00:30:08 - The IGF-1 Question00:36:10 - Why Kefir Is DifferentDr. Katie also shares what she's observing in her own practice about IGF-1 levels in patients who are eating long-cultured dairy, a question her fasting community has been asking about for a long time.By the end, you'll understand what kind of dairy may support your microbiome, why long culturing matters, and how Monica recommends making yogurt or kefir at home.Press play and learn how an ancient food you may have written off could become one of the most overlooked tools in your healing toolkit.Chef Monica's Books: https://simplybeingwell.com/2nd-ed-gaps-complete-bookJoin Dr. Katie's 3-Day Guided Fast, for expert support, daily live calls, and a community to fast alongside: Sign-Up Follow Dr. Katie Deming on InstagramWatch on YoutubeDISCLAIMER: The Born to Heal Podcast  is intended for informational purposes only and is not a substitute for seeking professional medical advice, diagnosis, or treatment. Individual medical histories are unique; therefore, this episode should not be used to diagnose, treat, cure, or prevent any disease without consulting your healthcare provider.A thought-provoking podcast explores cancer through the lens of holistic medicine and functional medicine, discussing causes of cancer, metabolic health, and unconventional approaches like water fasting, fasting and autophagy, and detox, while weighing fasting benefits against chemo side effects and radiation side effects, sharing stories of a cancer survivor navigating chemotherapy, natural medicine, holistic healing, and even spiritual healing on the path toward cancer remission and holistic health. 

Sponsored By:→ Neuro | Go to https://getneuro.com and use code ONEDAY at checkout for 15% OFF your entire order.The wellness internet runs on fear. Simon Hill doesn't.Jon Bier sits down with Simon Hill — physiotherapist, nutritionist, host of The Proof podcast, and one of the most genuinely balanced voices in a space that rewards extremism — for a conversation about what the science actually says versus what gets clicks. Peptides. GLP-1s. Testosterone. Longevity. IGF-1. Seed oils. These are the topics everyone is shouting about right now, and Simon is one of the few people who will actually slow down and read the evidence before forming an opinion.This isn't a conversation about fear. It's a conversation about clarity — and why the most dangerous thing in health right now might be the confidence with which people are saying things they don't actually know.Jon brings the curiosity. Simon brings the receipts. The result is one of the most honest conversations about longevity, biohacking, and what it means to actually take care of yourself that you'll find anywhere.In this episode: • Why the peptide boom deserves more caution than the wellness world is giving it — and what the IGF-1 and cancer research actually says about forcing the system • The CT scan technology that can now detect vulnerable plaque before a heart attack happens, and why Simon's dad's heart attack at 41 put him on this path • What genuine longevity thinking looks like when you strip away the extremism — and why the most important health decisions often come down to individual risk tolerance, not universal rulesFind Simon: • Instagram: https://www.instagram.com/simonhill/ • The Proof Podcast: https://www.theproof.com • The Proof on Instagram: https://www.instagram.com/theproof/Timestamps:0:00 - Intro0:49 - Why Jon Thinks About His Mom When He Creates Content2:10 - The Peptide Warning That Started a Debate4:44 - What the New Yorker Found When They Third Party Tested Peptides7:45 - Why Whoop Was the Best Investment He Ever Made11:47 - RFK, Compounding Pharmacies, and Why Regulation Could Help16:58 - Why Longevity Matters and What He's Missing in the Meantime23:37 - The Day His Dad Had a Heart Attack at 4127:00 - How AI Is Revealing the Real Story Inside Your Arteries41:49 - Why Most Supplements Are Useless Until You Do the Basics48:42 - The Creatine Gummy Scam Nobody Saw Coming1:01:29 - He Was on Testosterone When He Tried to Have Kids. His Count Was Zero

Hey everybody, this is the May 2026 Q&A video, and we made it through a packed hour of your questions. I had so many submitted that I had to print them off and group them by category to get through them all.All My Links Here: ⁠https://hunterwilliamshealth.com/links⁠We cover a lot of ground. GLPs and fertility, hunger on retatrutide, dopamine differences between Sema, Tirz, and Retta, GLP side effects and how to manage them. Then we move into hormones and HRT, including the right starting dose of testosterone, kisspeptin for fertility, progesterone dosing for women, and why so many doctors are starting guys way too low.From there we get into GH peptides and IGF cycling, my full injury healing stack, autoimmune protocols, cognitive stacks for studying, cosmetic questions, heart health, bone density, thyroid, and a long miscellaneous section covering rapamycin, MOTS-c, prostate peptides, traveling with peptides, and more.I also share the new AI chat tool I built that is trained only on my content. It is at chat.hunterwilliamshealth.com if you want to play with it.Thanks for submitting these. Keep them coming. See you in June.⚠️ For research and entertainment purposes only. ⚠️

João Almeida (CDS) confia na decisão de Luís Neves. Luís Paulo Fernandes (Chega) diz que Viegas Nunes não tem "crédito" e Isabel Mendes Lopes (Livre) quer ler relatório da IGF para dissolver dúvidas.See omnystudio.com/listener for privacy information.

Go to NutronicsLabs.com for 50% off with autoship + a FREE platinum bottle of IGF-1. Use code “MELK” for an extra 10% off! We The People must stand strong, stay united, resolute, calm, and focus on the mission. Pre-Order Mel's New Book Infiltration Instead of Invasion (America Betrayed 1944-1954) Today! Mel K reveals the rise of a global elite who infiltrated our country instead of invading it. Order Mel's New Book: Americans Anonymous: Restoring Power to the People One Citizen at a Time https://themelkshow.com/book The Show's Partners Page: https://themelkshow.com/partners/ Consider Making A Donation: https://themelkshow.com/donate/ Beverly Hills Precious Metals Exchange - Buy Gold & Silver https://themelkshow.com/gold/ Speak with Gold Expert Andrew Sorchini…Tell Him Mel K Sent You! Dr. Zelenko Immunity Protocols https://zstacklife.com/MelK I trust SatellitePhoneStore when all other networks fail. With their phone, I know I'm always connected, no matter where I am or what happens. https://sat123.com/melk/ I've tried a lot of supplements over the years, but nothing has compared to the purity and results I've experienced with Chemical Free Body. USE CODE MELK Mel K Superfoods Supercharge your wellness with Mel K Superfoods Use Code: MELKWELLNESS and Save Over $100 off retail today! https://themelkshow.com/partners/ Healthy Hydration: https://themelkshow.com/partners/ Patriot Mobile Support your values, your freedom and the Mel K Show. Switch to Patriot Mobile for Free. Use free activation code MELK https://themelkshow.com/partners/ HempWorx The #1 selling CBD brand. Offering cutting edge products that run the gamut from CBD oils and other hemp products to essential oils in our Mantra Brand, MDC Daily Sprays which are Vitamin and Herb combination sprays/ https://themelkshow.com/partners/ Dr. Zelenko Immunity Protocols https://zstacklife.com/MelK Support Patriots With MyPillow Go to https://www.mypillow.com/melk Use offer code “MelK” to support both MyPillow and The Mel K Show The Wellness Company - Emergency Medical Kits: https://themelkshow.com/partners/ Dr. Stella Immanuel, MD. Consult with a renowned healthcare provider! Offering Telehealth Services & Supplements. Use offer code ‘MelK' for 5% Off https://themelkshow.com/partners/ Rumble (Video) - The Mel K Show: https://rumble.com/c/TheMelKShow X: https://twitter.com/MelKShow Twitter (Original): https://twitter.com/originalmelk TRUTH Social: https://truthsocial.com/@themelkshow Instagram: https://www.instagram.com/themelkshow/ Podbean: https://themelkshow.podbean.com/ GETTR: https://www.gettr.com/user/themelkshow Locals.com: https://melk.locals.com/ Banned Video: https://banned.video/channel/the-mel-k-show We at www.themelkshow.com want to thank all our amazing patriot pals for joining us on this journey, for your support of our work, and for your faith in this biblical transition to greatness. Together we are unstoppable. We look forward to seeing you. God Wins! https://themelkshow.com/events/ Remember to mention Mel K for great discounts on all these fun and informative events. See you there! Our Website www.TheMelKShow.com We love what we do and are working hard to keep on top of everything to help this transition along peacefully and with love. Please help us amplify our message: Like, Comment & Share!  

Dr. Ksenia Petrushkina joins Dr. Mike Hart for a deep dive into regenerative medicine, peptides, hormones, IV therapies, and longevity. They discuss what conventional medicine and health influencers often get wrong about prevention-focused care, while exploring topics like NAD+, glutathione, GLP-1s, gut health, skin aging, mitochondrial health, BPC-157, TB-500, IGF-1, and peptide safety. Dr. Ksenia also shares why testing, inflammation, absorption, and overall health matter before using peptides or other optimization treatments. Dr. Ksenia Petrushkina is a regenerative medicine practitioner based in Aventura, Florida, and part owner of Ideal Medical and Wellness. Her work focuses on hormones, peptides, IV therapies, stem cells, and longevity, with a background in biopharmaceutical science and cancer research. She brings a prevention-focused, mechanism-based perspective to patient care, especially around inflammation, gut health, metabolic function, peptide safety, and age-related optimization. Dr. Ksenia Miami Instagram https://www.instagram.com/dr.kseniamiami/](https://www.instagram.com/dr.kseniamiami/) Ideal Medical and Wellness https://idealmedwell.com/](https://idealmedwell.com/) Tadalafil / Cialis https://medlineplus.gov/druginfo/meds/a604008.html](https://medlineplus.gov/druginfo/meds/a604008.html) PT-141 / Bremelanotide [https://medlineplus.gov/druginfo/meds/a619054.html](https://medlineplus.gov/druginfo/meds/a619054.html) GHK-Cu copper peptide https://pmc.ncbi.nlm.nih.gov/articles/PMC6073405/](https://pmc.ncbi.nlm.nih.gov/articles/PMC6073405/) Tretinoin / Retin-A https://medlineplus.gov/druginfo/meds/a682437.html](https://medlineplus.gov/druginfo/meds/a682437.html) NAD+ https://pmc.ncbi.nlm.nih.gov/articles/PMC7963035/](https://pmc.ncbi.nlm.nih.gov/articles/PMC7963035/) Nicotinamide Riboside / NR https://pmc.ncbi.nlm.nih.gov/articles/PMC6611812/](https://pmc.ncbi.nlm.nih.gov/articles/PMC6611812/) Tru Niagen [https://www.truniagen.com/](https://www.truniagen.com/) Glutathione https://pmc.ncbi.nlm.nih.gov/articles/PMC4684116/](https://pmc.ncbi.nlm.nih.gov/articles/PMC4684116/) GLP-1 drugs https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/fdas-concerns-unapproved-glp-1-drugs-used-weight-loss](https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/fdas-concerns-unapproved-glp-1-drugs-used-weight-loss) Tirzepatide https://medlineplus.gov/druginfo/meds/a622044.html](https://medlineplus.gov/druginfo/meds/a622044.html) BPC-157 https://www.usada.org/spirit-of-sport/bpc-157-peptide-prohibited/](https://www.usada.org/spirit-of-sport/bpc-157-peptide-prohibited/) TB-500 / Thymosin beta-4 https://pubmed.ncbi.nlm.nih.gov/22074294/](https://pubmed.ncbi.nlm.nih.gov/22074294/) Melanotan II https://dermnetnz.org/topics/melanotan-ii](https://dermnetnz.org/topics/melanotan-ii) IGF-1 test https://medlineplus.gov/lab-tests/igf-1-insulin-like-growth-factor-1-test/](https://medlineplus.gov/lab-tests/igf-1-insulin-like-growth-factor-1-test/) Tesamorelin https://medlineplus.gov/druginfo/meds/a611035.html](https://medlineplus.gov/druginfo/meds/a611035.html)   Thymosin Alpha-1 https://pmc.ncbi.nlm.nih.gov/articles/PMC7747025/](https://pmc.ncbi.nlm.nih.gov/articles/PMC7747025/) SS-31 / Elamipretide https://pmc.ncbi.nlm.nih.gov/articles/PMC11816484/](https://pmc.ncbi.nlm.nih.gov/articles/PMC11816484/) Urolithin A https://pubmed.ncbi.nlm.nih.gov/35050355/](https://pubmed.ncbi.nlm.nih.gov/35050355/) Coenzyme Q10 / CoQ10 https://www.nccih.nih.gov/health/coenzyme-q10](https://www.nccih.nih.gov/health/coenzyme-q10) Pancreatic enzymes https://medlineplus.gov/druginfo/meds/a604035.html](https://medlineplus.gov/druginfo/meds/a604035.html) Psyllium husk https://medlineplus.gov/druginfo/meds/a601104.html](https://medlineplus.gov/druginfo/meds/a601104.html)   Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:38 Preventive Medicine Debate 03:03 Low Dose Cialis Basics 05:03 Prostate Cancer Link 08:18 ED Alternatives PT-141 11:52 Skin Aging Essentials 12:19 GHK-Cu Dosing Risks 15:59 Copper Uglies Explained 19:47 NAD Boosting Options 24:33 NR Infusions Trend 27:38 Glutathione and Thyroid 31:58 Stopping Levothyroxine 33:34 Glutathione Precursors Limits 34:58 Gut Protocol NAD GLP1 35:59 Tirzepatide Microdosing Guide 38:18 Glutathione Injection Protocol 40:47 BPC 157 Cancer Myth 43:28 BPC TB500 Injury Cycles 45:13 Melanotan II Skin Risks 46:50 IGF1 Aging Tradeoffs 49:16 Safest GH Secretagogue 50:05 Underrated Thymosin Alpha 52:35 Mitochondria Peptides SS31 55:00 MITC and AMPK Hype 56:36 Urolithin A and CoQ10 01:00:36 GLP1 Supplements and Labs 01:02:39 Wrap Up and Where to Find   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

APR Health Solutions Peptides: www.aprhealthsolutions.com - code nyleOptimize HRT Clinic: https://members.optimize-hp.com - code nyleMerch: https://www.aykons.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'nyle' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘nyle' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comRP Hypertrophy Training App: rpstrength.com/nyle (code nyle)Timestamps:00:00:00 Intro00:02:04 Sarcoplasmic vs. Myofibrillar Training00:06:11 Overtraining & Serbian Diet00:08:20 High-Protein Strategy & Food Visualization00:14:12 The Five-Year Plan & Olympia Regrets00:16:27 Training Back with Ronnie Coleman00:20:20 Arm Blasting & Training Splits00:23:44 Training Long vs. Training Hard00:26:16 Modern Stress & Recovery00:28:02 Giant Sets & Peak Contractions00:32:45 Gym Ethics & The Colosseum Rule00:35:03 Peptide Optimization & Liver Protection00:37:05 IGF-1 Protocols & Injection Science00:41:45 Needle Length & The Golden Era of 199700:45:52 Nile's Quad Protocol & Leg Sweeps00:49:57 V-Taper, Waist Size, & Classic Criteria00:55:41 The Oncology Risks of IGF-101:01:12 Debunking the Insulin Myth with Dave Palumbo01:13:10 Pre-Workout Insulin & Nutrient Loading01:22:07 Optimize HRT & Bloodwork Management01:25:54 Low-Dose Thyroid Hormones (T3/T4)01:34:59 Longevity, Joint Health, & Synthol Disasters01:39:58 Cruising vs. "Half On, Half Off" Cycles01:44:08 Off-Cycle Training & Muscle Memory01:52:00 Peptides (BPC-157/TB-500) & The Placebo Effect02:02:18 Post-Show Rebound Strategy02:09:14 Jean Pierre Fux vs. Marcus Ruhl02:13:51 DHB (Dihydroboldenone) vs. Masteron/Primo02:16:35 Milos' Maximum Cycle Dosages02:18:14 Posing Artistry vs. Bodybuilding Judging02:22:08 Terrible Genetics & Overcoming Limitations02:24:33 1999: Milos' Biggest Year & Synthol Regrets02:28:21 The Holy Trinity: Test, GH, & Insulin Synergy02:28:55 Masteron vs. Primobolan Contest Selection02:30:26 Steve's "Bathmate & hCG" Protocol02:32:43 Generic vs. Pharmaceutical Growth Hormone02:36:45 Most Underrated & Overrated PEDs02:38:23 Final Message: Legacy, Love, & Simplicity00:00:00 Intro00:02:04 Sarcoplasmic vs. Myofibrillar Training00:06:11 Overtraining & Serbian Diet00:08:20 High-Protein Strategy & Food Visualization00:14:12 The Five-Year Plan & Olympia Regrets00:16:27 Training Back with Ronnie Coleman00:20:20 Arm Blasting & Training Splits00:23:44 Training Long vs. Training Hard00:26:16 Modern Stress & Recovery00:28:02 Giant Sets & Peak Contractions00:32:45 Gym Ethics & The Colosseum Rule00:35:03 Peptide Optimization & Liver Protection00:37:05 IGF-1 Protocols & Injection Science00:41:45 Needle Length & The Golden Era of 199700:45:52 Nile's Quad Protocol & Leg Sweeps00:49:57 V-Taper, Waist Size, & Classic Criteria00:55:41 The Oncology Risks of IGF-101:01:12 Debunking the Insulin Myth with Dave Palumbo01:13:10 Pre-Workout Insulin & Nutrient Loading01:22:07 Optimize HRT & Bloodwork Management01:25:54 Low-Dose Thyroid Hormones (T3/T4)01:34:59 Longevity, Joint Health, & Synthol Disasters01:39:58 Cruising vs. "Half On, Half Off" Cycles01:44:08 Off-Cycle Training & Muscle Memory01:52:00 Peptides (BPC-157/TB-500) & The Placebo Effect02:02:18 Post-Show Rebound Strategy02:09:14 Jean Pierre Fux vs. Marcus Ruhl02:13:51 DHB (Dihydroboldenone) vs. Masteron/Primo02:16:35 Milos' Maximum Cycle Dosages02:18:14 Posing Artistry vs. Bodybuilding Judging02:22:08 Terrible Genetics & Overcoming Limitations02:24:33 1999: Milos' Biggest Year & Synthol Regrets02:28:21 The Holy Trinity: Test, GH, & Insulin Synergy02:28:55 Masteron vs. Primobolan Contest Selection02:30:26 Steve's "Bathmate & hCG" Protocol02:32:43 Generic vs. Pharmaceutical Growth Hormone02:36:45 Most Underrated & Overrated PEDs02:38:23 Final Message: Legacy, Love, & Simplicity

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Go to NutronicsLabs.com for 50% off with autoship + a FREE platinum bottle of IGF-1. Use code “MELK” for an extra 10% off!   We The People must stand strong, stay united, resolute, calm, and focus on the mission. Order Mel's New Book: Americans Anonymous: Restoring Power to the People One Citizen at a Time https://themelkshow.com/book The Show's Partners Page: https://themelkshow.com/partners/ Consider Making A Donation: https://themelkshow.com/donate/ Beverly Hills Precious Metals Exchange - Buy Gold & Silver https://themelkshow.com/gold/ Speak with Gold Expert Andrew Sorchini…Tell Him Mel K Sent You! Dr. Zelenko Immunity Protocols https://zstacklife.com/MelK I trust SatellitePhoneStore when all other networks fail. With their phone, I know I'm always connected, no matter where I am or what happens. https://sat123.com/melk/ I've tried a lot of supplements over the years, but nothing has compared to the purity and results I've experienced with Chemical Free Body. USE CODE MELK Mel K Superfoods Supercharge your wellness with Mel K Superfoods Use Code: MELKWELLNESS and Save Over $100 off retail today! https://themelkshow.com/partners/ Healthy Hydration: https://themelkshow.com/partners/ Patriot Mobile Support your values, your freedom and the Mel K Show. Switch to Patriot Mobile for Free. Use free activation code MELK https://themelkshow.com/partners/ HempWorx The #1 selling CBD brand. Offering cutting edge products that run the gamut from CBD oils and other hemp products to essential oils in our Mantra Brand, MDC Daily Sprays which are Vitamin and Herb combination sprays/ https://themelkshow.com/partners/ Dr. Zelenko Immunity Protocols https://zstacklife.com/MelK Support Patriots With MyPillow Go to https://www.mypillow.com/melk Use offer code “MelK” to support both MyPillow and The Mel K Show The Wellness Company - Emergency Medical Kits: https://themelkshow.com/partners/ Dr. Stella Immanuel, MD. Consult with a renowned healthcare provider! Offering Telehealth Services & Supplements. Use offer code ‘MelK' for 5% Off https://themelkshow.com/partners/ Rumble (Video) - The Mel K Show: https://rumble.com/c/TheMelKShow X: https://twitter.com/MelKShow Twitter (Original): https://twitter.com/originalmelk TRUTH Social: https://truthsocial.com/@themelkshow Instagram: https://www.instagram.com/themelkshow/ Podbean: https://themelkshow.podbean.com/ GETTR: https://www.gettr.com/user/themelkshow Locals.com: https://melk.locals.com/ Banned Video: https://banned.video/channel/the-mel-k-show We at www.themelkshow.com want to thank all our amazing patriot pals for joining us on this journey, for your support of our work, and for your faith in this biblical transition to greatness. Together we are unstoppable. We look forward to seeing you. God Wins! https://themelkshow.com/events/ Remember to mention Mel K for great discounts on all these fun and informative events. See you there! Our Website www.TheMelKShow.com We love what we do and are working hard to keep on top of everything to help this transition along peacefully and with love. Please help us amplify our message: Like, Comment & Share!

Go to NutronicsLabs.com for 50% off with autoship + a FREE platinum bottle of IGF-1. Use code “MELK” for an extra 10% off!   We The People must stand strong, stay united, resolute, calm, and focus on the mission. Order Mel's New Book: Americans Anonymous: Restoring Power to the People One Citizen at a Time https://themelkshow.com/book The Show's Partners Page: https://themelkshow.com/partners/ Consider Making A Donation: https://themelkshow.com/donate/ Beverly Hills Precious Metals Exchange - Buy Gold & Silver https://themelkshow.com/gold/ Speak with Gold Expert Andrew Sorchini…Tell Him Mel K Sent You! Dr. Zelenko Immunity Protocols https://zstacklife.com/MelK I trust SatellitePhoneStore when all other networks fail. With their phone, I know I'm always connected, no matter where I am or what happens. https://sat123.com/melk/ I've tried a lot of supplements over the years, but nothing has compared to the purity and results I've experienced with Chemical Free Body. USE CODE MELK Mel K Superfoods Supercharge your wellness with Mel K Superfoods Use Code: MELKWELLNESS and Save Over $100 off retail today! https://themelkshow.com/partners/ Healthy Hydration: https://themelkshow.com/partners/ Patriot Mobile Support your values, your freedom and the Mel K Show. Switch to Patriot Mobile for Free. Use free activation code MELK https://themelkshow.com/partners/ HempWorx The #1 selling CBD brand. Offering cutting edge products that run the gamut from CBD oils and other hemp products to essential oils in our Mantra Brand, MDC Daily Sprays which are Vitamin and Herb combination sprays/ https://themelkshow.com/partners/ Dr. Zelenko Immunity Protocols https://zstacklife.com/MelK Support Patriots With MyPillow Go to https://www.mypillow.com/melk Use offer code “MelK” to support both MyPillow and The Mel K Show The Wellness Company - Emergency Medical Kits: https://themelkshow.com/partners/ Dr. Stella Immanuel, MD. Consult with a renowned healthcare provider! Offering Telehealth Services & Supplements. Use offer code ‘MelK' for 5% Off https://themelkshow.com/partners/ Rumble (Video) - The Mel K Show: https://rumble.com/c/TheMelKShow X: https://twitter.com/MelKShow Twitter (Original): https://twitter.com/originalmelk TRUTH Social: https://truthsocial.com/@themelkshow Instagram: https://www.instagram.com/themelkshow/ Podbean: https://themelkshow.podbean.com/ GETTR: https://www.gettr.com/user/themelkshow Locals.com: https://melk.locals.com/ Banned Video: https://banned.video/channel/the-mel-k-show We at www.themelkshow.com want to thank all our amazing patriot pals for joining us on this journey, for your support of our work, and for your faith in this biblical transition to greatness. Together we are unstoppable. We look forward to seeing you. God Wins! https://themelkshow.com/events/ Remember to mention Mel K for great discounts on all these fun and informative events. See you there! Our Website www.TheMelKShow.com We love what we do and are working hard to keep on top of everything to help this transition along peacefully and with love. Please help us amplify our message: Like, Comment & Share!

One of my clients just got results that normally only come from drugs, hormone replacement therapy, or some extreme program.But we didn't use medication or hormones.We didn't use a crazy diet..And we definitely didn't overhaul his entire life overnight.In today's episode, I'll explain what we did to achieve incredible results. These results speak for themselves

In this episode, Ben and Giacomo are joined by Dr. Michael Greger to discuss one of the most debated topics in nutrition and fitness: protein intake. The conversation covers how much protein we actually need, the potential longevity tradeoffs of excessive protein consumption, and why plant protein may offer unique advantages compared to animal protein.Dr. Greger explains the role of methionine restriction, IGF-1, and mTOR in aging, while also emphasizing the importance of resistance training and muscle mass for long-term health. The group discusses fall prevention, balance training, sarcopenia, insulin sensitivity, and the challenges of communicating science in today's attention economy.The episode wraps up with practical nutrition advice, thoughts on protein powders versus whole foods, and Dr. Greger's enthusiasm for broccoli sprouts and sulforaphane-rich foods.Dr. Greger's Bio: Dr. Michael Greger is a physician, internationally recognized nutrition speaker, and founding Fellow of the American College of Lifestyle Medicine. He runs the nonprofit NutritionFacts.org, which provides free evidence-based nutrition videos and articles. A graduate of Cornell University and Tufts University School of Medicine, Dr. Greger has lectured at the World Bank, testified before Congress, and served as an expert witness in Oprah Winfrey's “meat defamation” trial. He is the bestselling author of How Not to Die, How Not to Diet, and How Not to Age. All proceeds from his books and speaking engagements are donated to charity.

Hosts: Ed Jones (Owner – Nutrition World) & Clint Powell A variety of topics all related to living a healthy life Presented by: Nutrition World www.nutritionw.com Broadcasting from the Nooga Dentistry Studio www.noogadentistry.com Production of: Whitfield Media Group www.vitalhealthradio.com Title: All About Peptides, & The Good, Bad & Ugly of GLP-1's [0:00:00]  Ed's Restaurant Story & Healthy Eating Choices Ed's recurring bit: “Where did Ed eat this week?” Long‑time favorite restaurant Epicurean. Discussion of consistent healthy ordering and making good choices at long‑standing, family‑owned restaurants. [0:03:13]  Building a Health “Team” & Ed's Top Learning Resources Tease of today's main topic: peptides with local expert Noel Lawson, NP. Ed stresses “team approach” to aging—no single practitioner has all the answers. Learners vs. non‑learners: why ongoing self‑education is critical for health. Ed's 4 favorite online resources: Mercola.com – more cutting‑edge, sometimes controversial content. DrJockers.com – accessible, visual education on ailments and nutrients. GreenMedInfo.com – indexed medical literature backing natural claims. Nutrition World Instagram – short, practical health “snippets”. Story: Nutrition World wins a surprise $10,000 award from Ancient Nutrition for #1 sales growth in the U.S., tied to belief in product quality. [0:10:38] Introducing Noel Lawson & “What Are Peptides?” Introduction of Noel Lawson, NP (Double Bridges Health & Wellness), now practicing on the Nutrition World campus. Noel's background: Transition from traditional medicine to functional medicine due to patient frustration, worsening chronic illness, and provider burnout. Goal: more prevention and root‑cause care. Orthopedic background led her to peptides. What is a peptide? Peptides are like the body's Morse code—specific chains of amino acids acting as signals. Under ~40 amino acids = peptide; longer chains = protein. Body breaks down dietary protein into amino acids and re‑assembles them into peptides as needed (e.g., for repair). As we age, the body produces fewer peptides, which is why we heal slower and are more prone to injury and inflammation. [0:19:26] Functional Medicine + Peptides: Approach, Expectations & Use Noel's approach: Combines functional medicine with peptides. Peptides only work well if the materials (sleep, nutrients, stress management, movement) are in place. Uses comprehensive labs to optimize baseline health first. Delivery & protocols: ~90% of peptides are injectable (tiny insulin‑type needle, usually daily). Some oral options exist Local injections near the injury area Expectations & timelines First 2–3 weeks: less inflammation, modest improvement in pain, sleep, and energy. 6–8 weeks: improved range of motion and strength. After 3 months: realistic minimum for true tissue change; peptides can't shortcut normal cell‑turnover timelines. [0:21:41] Specific Peptides & Treatment Logistics High‑demand musculoskeletal peptides: BPC‑157 and TB‑500: commonly used for tendons, ligaments, muscle and injury recovery. Growth hormone related peptides: Examples: samorelin, CJC, ipamorelin, tesamorelin. Stimulate the pituitary to release natural human growth hormone (HGH) rather than supplying exogenous HGH. Potential benefits: lean muscle mass, better body composition, cardiometabolic support. Monitored via IGF‑1 levels to avoid excess. PT‑141 for sexual health: Crosses the blood–brain barrier and activates pleasure/desire centers. Can cause nausea in some people; alternative forms (nasal spray, sublingual troche) may reduce side effects. How Noel works with patients: Website: doublebridgeswellness.com Contact form → email → optional free 20‑minute expectations call to see if there's a good fit. 1‑hour new patient visits, not rushed; she practices on the Nutrition World campus. [0:35:01] GLP‑1 Drugs (Ozempic, Trulicity, Mounjaro): Good, Bad & Ugly Case study: 65‑year‑old woman with pre‑existing gastroparesis put on Trulicity. Developed severe vomiting, dehydration, abdominal pain; was initially reassured to “get used to it.” Second dose led to life‑threatening pancreatitis, requiring hospitalization. Later prescribed Mounjaro by same clinic despite this history. The “Good” of GLP‑1s: In Curt's clinic, used selectively for: Poorly controlled diabetes (A1c > 10, average sugars in the 300s). Significant obesity. Can lower blood sugar and drive weight loss, by suppressing appetite The “Bad”: Common GI side effects (up to ~50% of users): Nausea, vomiting, constipation. Worsening gastroparesis (slow gut motility). Rapid weight loss often includes loss of muscle and bone, not just fat—hurts longevity and functional strength. Ozempic face: gaunt facial appearance from aggressive fat/muscle loss. Risk of hypoglycemia Visual issues, including increased macular degeneration risk. Psychiatric concerns: Emerging data on increased suicidal ideation, especially notable because trials excluded psychiatric patients. The “Ugly”: Pancreatitis, gallbladder problems. Thyroid tumors in some models. Possible cardiac atrophy. Massive growth in use: tens of millions prescribed, with many discontinuing within a year due to side effects or cost. Risk that people treat GLP‑1s as a “magic bullet” without nutrition or lifestyle change—and regain ~85% of lost weight after stopping. Curt's conclusion: GLP‑1s should be reserved for specific, high‑risk cases and paired with close coaching. For most people, there are safer, natural options. [0:50:12] “Nature's Ozempic,” Gut Health & Upcoming Events Ed and Curt on supporting GLP‑1 pathways naturally: Berberine – “nature's Ozempic” for blood sugar and metabolic support. Akkermansia (probiotic strain) – gut health, metabolic benefits, GLP‑1 stimulation. Butyrate – short‑chain fatty acid that: Supports gut lining / leaky gut repair. Improves colon health and may help increase GLP‑1. Ed reports best bowel function of his life using 2 caps/day. People who start GLP‑1s often increase supplement use, but tend to stop supplements when the drug stops. Coaching is needed so they maintain nutrition and supplementation after GLP‑1 discontinuation. Practical tips & announcements: Colonoscopies: clear protein drinks are now typically allowed on prep day—can help preserve muscle and stabilize blood sugar. Upcoming Lunch & Learn (online): Topic: “The Microbiome's Impact on Longevity”. Format: Instagram Live (@NutritionWorld), Tuesday, May 5 at 12:15 PM. Upcoming in‑person lecture at Nutrition World campus: Topic: “Taming the Yeast: Candida‑Reducing Strategies”. Thursday, May 21 at 5:30 PM. Registration via nutritionw.com → Events. Closing: Ed and Clint wrap up, reiterating their mission of clear, actionable health guidance and noting the show will be out on major podcast platforms. The post Radio Show / Podcast – May 3, 2026 first appeared on Vital Health Radio.

On this week's Crewcast, the IGF award-winning Titanium Court has opened its curtains, Shapez 2 cuts its way out of Early Access, they let a rodent be a detective in Mouse: P.I. For Hire, and we ponder the most important question: who invented numbers? The artist that Jeremy mentioned on itch.io that makes those crunchy pre-rendered visuals: https://fedan-marian.itch.io/ Titanium Court: https://store.steampowered.com/app/2364580/Titanium_Court/ Mouse: P.I. For Hire: https://store.steampowered.com/app/2416450/MOUSE_PI_For_Hire/ ARC Raiders: https://store.steampowered.com/app/1808500/ARC_Raiders/ Shapez 2: https://store.steampowered.com/app/2162800/shapez_2__Factory/ Windrose: https://store.steampowered.com/app/3041230/Windrose/ Assassin's Creed Black Flag Resynced: https://store.steampowered.com/app/3751950/Assassins_Creed_Black_Flag_Resynced/ Yunyun Syndrome!? Rhythm Psychosis: https://store.steampowered.com/app/2914150/Yunyun_Syndrome_Rhythm_Psychosis/ PRAGMATA: https://store.steampowered.com/app/3357650/PRAGMATA/ LOVE ETERNAL: https://store.steampowered.com/app/3010610/LOVE_ETERNAL/ iTunes Page: https://itunes.apple.com/us/podcast/noclip/id1385062988 RSS Feed: http://noclippodcast.libsyn.com/rss Spotify: https://open.spotify.com/show/5XYk92ubrXpvPVk1lin4VB?si=JRAcPnlvQ0-YJWU9XiW9pg Soundcloud: https://soundcloud.com/noclippodcast Watch our docs: https://youtube.com/noclipvideo Crewcast channel: https://www.youtube.com/channel/noclippodcast Follow our games coverage escapades: https://www.youtube.com/@Noclip2 Learn About Noclip: https://www.noclip.video Become a Patron and get early access to new episodes: https://www.patreon.com/noclip Chapters: 0:00:00 - Intro 0:02:57 - Thanking our Patreon supporters! 0:06:17 - Titanium Court 0:21:05 - Mouse: P.I. For Hire 0:28:13 - ARC Raiders: Riven Tides Update 0:42:59 - Shapez 2 1.0 0:55:16 - Who invented numbers? 0:59:45 - Windrose 1:06:13 - Assassin's Creed IV Black Flag Resynced 1:13:10 - Yunyun Syndrome!? Rhythm Psychosis 1:17:54 - PRAGMATA 1:20:30 - Love Eternal 1:22:13 - Q: Any good underrated stealth games? 1:30:15 - Q: Do you overanalyze when playing for fun? 1:39:39 - Noclip Updates 1:45:56 - Sign Off

Send us Fan MailDr. Rangasamy Ramanathan, division chief at Cedars-Sinai Guerin Children's Hospital and one of neonatology's most prolific investigators, joins Ben to share what's keeping him busy — 14 active clinical trials including studies on IGF-1 for lung injury prevention, oral insulin for weight gain, and the upcoming phase three trial of aerosolized surfactant. He reflects on what has sustained his passion through decades of work, from training a third of California's neonatologists to launching Southern California's first NeuroNICU with 24-7 neurology coverage and in-house whole genome sequencing. He also previews his next innovation — the ROM Smith ventilator, designed to be manufactured and distributed at cost to resource-limited settings around the world where babies are dying for lack of a $30,000 machine he believes he can build for under $2,000.Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.Enjoy!

Your day is getting programmed whether you choose it or not, and the “golden hours” after waking and before sleep are where that programming sticks. I walk through what's happening in the brain and nervous system during those windows, why we're more suggestible and neuroplastic, and how a few small choices can shift your baseline from reactive to regulated. If your mornings start with scrolling, stress, and quick dopamine hits, you may be teaching your body to crave agitation, distraction, and tunnel vision all day long.I share my flexible, repeatable morning routine built around spirit, mind, and body: meditation done out of bed, intention setting that acts like a GPS for your subconscious, and gratitude to create heart-brain coherence. We also talk about discipline versus willpower, how to create natural dopamine through learning, and how movement and breathwork help clear cortisol so you can think bigger, feel steadier, and respond instead of react. These are practical nervous system regulation tools you can adapt to any season of life.Then we pivot to a topic I'm seeing everywhere: protein. Can you overdo it? Absolutely. I explain why protein can still drive insulin, how excess can spill over into glucose production and fat storage, and which symptoms can signal “too much” for your body, from digestion and dehydration to sleep disruption and hot flashes. We zoom out into pathways, not just macros, comparing mTOR and IGF-1 growth signaling with AMPK, ketosis, and autophagy so you can balance building muscle with cellular repair, metabolic health, and long-term longevity.If you're ready to stop copying influencers and start listening to your biofeedback, press play, then subscribe, and share this with a friend who's stuck in health noise!To work one-on-one with me, you can apply HERE!To get notified as soon as groups open up and other updates sign up/subscribe here:https://stacy-baker.mykajabi.com/opt-in-9cffc5f4-f006-4adb-a0a7-6c33a0698b4bResources mentioned:Ketone and Blood Sugar Testing MasterclassKetone TestingRa Optics (Code DRSTACYND) blue light blockersHigher Dose (my FAV sauna blanket with low to no EMF) code DRSTACYCGM *2 months free with code DRSTACYStructured/Living Water *code DRSTACYSpring Aqua (my FAV water system) For more from me, follow me on IG @dr.stacy.ndEpisodes Mentioned: Dairy Paradox/Insulin Impact Calorie Deficit versus FastingThank you for listening! This information is just that; information only - not to be taken as medical advice. Please contact your primary care before changing anything to your routine. This information is not mean to diagnose, treat, or cure disease.

Unlock early, ad-free access to The MinnMax Show and find a benefit that's right for you - https://www.patreon.com/minnmax This week on The MinnMax Show, Ben Hanson, Jacob Geller, Kyle Hilliard, and Jeff Marchiafava rave about Housemarque's new action roguelikes for PlayStation called Saros and discuss how the game compares to Returnal. This is a spoiler-free discussion and codes were provided by PlayStation. Then we talk about the excellent Vampire Crawlers: The Turbo Wildcard from Vampire Survivors and share the first hands-on preview impressions for Virtue and a Sledgehammer. Then Haley MacLean and special guest Deven McClure join the show to unpack Nintendo's strangest game in years: Tomodachi Life: Living The Dream and the IGF grand prize winning release of Titanium Court. Then we answer questions submitted on Patreon by the community and award the iam8bit question of the week! You can win a prize and help make the show better by supporting us on Patreon and submitting a question! https://www.patreon.com/minnmax Follow Deven's work or contact her with freelance opportunities here - www.devenmcclure.com Watch and share the video version here - https://youtu.be/FxL7WeTn92g Help support MinnMax's supporters! https://www.iam8bit.com - 10% off with Promo Code: FIREFLOWERS https://www.hellofresh.com/minnmax10fm - Get 10 free meals and more https://www.square.com/go/minnmax - Get up to $200 off Square hardware To jump to a particular discussion, check out the timestamps below... 00:00:00 - Intro 00:02:05 - Saros 00:26:12 - Hello Fresh 00:28:10 - Vampire Crawlers: The Turbo Wildcard from Vampire Survivors 00:40:44 - Virtue and a Sledgehammer 00:48:15 - Welcome Deven McClure/celebrities and red carpet events 00:55:52- Tomodachi Life: Living The Dream 01:13:15 - Square 01:15:12 - Titanium Court 01:25:44 - Thanking iam8bit - https://www.iam8bit.com/ 01:28:31 - Community questions 02:10:29 - Get A Load Of This Haley's GALOT - https://www.vice.com/en/article/what-are-scientology-runs-and-why-is-gen-z-so-obsessed-with-them/ Jacob's GALOT - https://www.theatlantic.com/magazine/2026/05/best-free-restaurant-bread-america/686582/ Hanson's GALOT - https://archive.org/details/pixars-scrapped-be-fri-movie-storyboard Deven's GALOT - https://www.amazon.com/Medieval-Bodies-Life-Death-Middle/dp/1324002166 JeffM's GALOT - https://www.youtube.com/watch?v=0dwagg5wYY4 https://www.youtube.com/watch?v=2ubYGdMCQTA Community GALOT - https://www.youtube.com/watch?v=IviltVZb9OA Disclosure - Games discussed on MinnMax content are most often provided for free by the publisher or developer. Support us on Patreon - https://www.patreon.com/minnmax Support MinnMax directly on YouTube - https://youtube.com/minnmax/join Follow us on Twitch - https://www.twitch.tv/minnmaxshow Subscribe to our YouTube channel - https://www.youtube.com/minnmax Subscribe to our solo stream channel - https://www.youtube.com/@minnmaxstreamarchives Buy MinnMax merch here - https://minnmax.com/merch Follow us on Bluesky - https://bsky.app/profile/minnmax.com Go behind the scenes on Instagram - https://www.instagram.com/minnmaxshow This podcast is powered by Pinecast.

Your brain is aging faster than it should, and most of the decline is self-inflicted. Neuroscientist Dr. Tommy Wood reveals the exact mechanisms driving cognitive decay, and the biohacking strategies backed by hard science that can stop it, reverse it, and future-proof your brain at any age. -Watch this episode on YouTube: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Tommy Wood, one of the most credentialed minds working at the intersection of brain optimization, human performance, and longevity. Dr. Wood holds a medical degree from the University of Oxford, a PhD in physiology and neuroscience from the University of Oslo, and serves as Associate Professor of Pediatrics and Neuroscience at the University of Washington School of Medicine. He has published over 100 scientific papers, consulted with Olympians and world champions across more than a dozen sports, and worked directly with Formula 1 drivers to sustain elite focus and reaction time at 200 miles per hour. His forthcoming book, The Stimulated Mind: Future-Proof Your Brain from Dementia and Stay Sharp at Any Age, is the culmination of decades of research and real-world application. Together, Dave and Dr. Wood dismantle the myth that cognitive decline is inevitable, exposing how societal expectations become self-fulfilling prophecies and how the tools of biohacking, including sleep optimization, neuroplasticity training, nootropics, supplements, and strategic exercise, can dramatically shift your brain's long-term trajectory. They dig into the 3S Model of brain health (Stimulus, Supply, Support), the Yerkes-Dodson arousal curve and what it means for focus and flow states, and the surprising truth about AI, boredom, and what actually happens to your brain when you let ChatGPT do your thinking for you. This episode is essential listening for anyone serious about anti-aging, brain optimization, functional medicine, metabolism, human performance, and getting smarter without working harder. You'll Learn: Why cognitive decline is largely a self-fulfilling prophecy driven by expectation, not biology How the 3S Model (Stimulus, Supply, Support) determines your brain's long-term health and resilience What Formula 1 drivers teach us about arousal, flow states, and peak cognitive performance Why high-intensity interval training produces dramatically greater neuroplasticity benefits than Zone 2 cardio alone How creatine, nicotine, nootropics, and other supplements actually affect the aging brain The real data on alcohol, dementia risk, and what "occasional drinking" actually means scientifically How to use AI tools like ChatGPT in a way that builds brain function instead of destroying it Why boredom is a neurological necessity and how chronic low-level stimulation is quietly eroding your cognition What mitochondria and lactate signaling have to do with BDNF and long-term memory How resistance training, coordinative movement, and blood flow restriction each deliver separate and distinct cognitive benefits Thank you to our sponsors! - KILLSwitch | If you're ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off - Neuronic | Go to www.neuronic.online Code DAVE for $100 off - Danger Coffee | Grab yours at DangerCoffee.comand use code DAVEPOD at checkout for 15% off. - Suppgrade Labs | Grab your DAKE and Minerals 101 duo at shopsuppgradelabs.com and use code DAVEPOD for 15% off today Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Tommy Wood, The Stimulated Mind, brain health, cognitive decline, dementia prevention, neuroplasticity, brain optimization, biohacking, Dave Asprey, human performance, longevity, 3S model, brain stimulation, headroom, cognitive reserve, BDNF, lactate, Zone 2, HIIT, resistance training, blood flow restriction, sleep optimization, nootropics, creatine, nicotine, acetylcholine, supplements, ADHD, arousal curve, flow state, Formula 1, anti-aging, mitochondria, metabolism, AI and the brain, ChatGPT, digital dementia, boredom, neurogenesis, hippocampus, white matter, IGF-1, osteocalcin, alcohol and dementia, TMS, TDCS, vagal nerve stimulation, near infrared light, functional medicine, cognitive stimulation, stereotype embodiment theory Resources: • Learn More About Tommy And His Work At His Website: https://www.drtommywood.com • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 — Trailer 01:28 — Guest Intro: Dr. Tommy Wood 03:37 — F1 Drivers & Arousal Optimization 09:01 — Brain Headroom & the 3S Model 13:14 — Brain Stimulation Tech (TMS, TDCS) 17:50 — Cognitive Decline & Aging 20:55 — Alcohol & Brain Health 24:10 — ADHD & Brain Chemistry 26:53 — Nicotine & Cognitive Enhancement 33:25 — Creatine for the Brain 35:12 — Zone 2 vs. High-Intensity Exercise 39:19 — Strength Training & Brain Benefits 43:12 — Boredom & Cognitive Resilience 45:06 — AI & Brain Health 52:49 — Future-Proofing Your Brain See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

(Hacker voice) I'm in. We're pentesting the mainfraime this week with 868-HACK! A small-scope puzzle-y rogue-y game by one Michael Brough: multi award-nominated IGF game designer of other similarly overlooked titles like Imbroglio, Cinco Paus, and Zaga-33. Michael's games were originally designed for iOS mobile devices back in the hallowed days of the early 2010s, in that bubbling time when roguelites were just getting their foothold. Listen in as we isolate the nodes, jack the creds, warp some viruses and dump them on the other side of the router. Think you got what it takes to hack the big leagues, kid, or are you one siphon short of getting point-attacked in the NCIS firewall? Custom RSS Apple Podcasts Spotify YouTube Music Transcript 1:08 - Game stats 6:51 - One sentence description 8:28 - Platform Origins: iOS First, PC Port, No Android 12:21 - Hacking Aesthetic, Art Style & Tutorial Walkthrough 17:24 - Points as Primary Goal Debate 22:27 - Run Scoring Systems 26:24 - Difficulty Escalation 33:23 - Gameplay debates 39:09 - Progs & Ability Combos 45:04 - Sound Design & Aesthetic 47:40 - 868-BACK Sequel 52:50 - Movie Hacking 1:00:34 - Plan B DLC Mechanics & Harder Starting Conditions 1:04:08 - Awards, Critical Acclaim & Eric Dolphy Jazz Analogy 1:10:30 - Rankings & final thoughts 1:24:06 - Similar games & show wind-down Next episode: UFO 50 Contact us at grogpodzone@gmail.com! https://grogpod.zone Intro music: GROGPOD Theme 1 by Balatro composer LouisF - https://louisfmusic.com/ Outro music: 868-HACK background music and 868-BACK background music

Most people assume water fasting is the gold standard — but the science tells a different story. When you remove water completely, your body activates a second autophagy pathway that water fasting simply cannot reach at any duration. One day of dry fasting can match three days of water fasting in cellular cleanup depth.In this video I break down exactly why:— Dry fasting triggers two independent autophagy pathways simultaneously— Your body produces its own deuterium-depleted water from fat (and external water shuts this off)— Hyperosmotic stress reorganises the cell's internal highway, enabling virophagy — the clearance of latent viral reservoirs— The cortisol surge + IGF-1 drop + HGH spike combination creates conditions water fasting can't replicate— Why the real healing happens 2–4 weeks after the fast ends, not during itThis is the mechanism behind The Scorch Protocol — a dry fasting, T3 therapy, and hGH framework built for reversing Long Covid, ME/CFS, and chronic illness.

The OG Mass MonsterAPR Health Solutions Peptides: www.aprhealthsolutions.com - code nyleOptimize HRT Clinic: https://members.optimize-hp.com - code nyleMerch: https://www.aykons.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'nyle' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘nyle' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comRP Hypertrophy Training App: rpstrength.com/nyleTimestamps:00:00:00 Intro00:02:18 Reinventing Bodybuilding Media00:04:24 The Mandate of Authenticity00:06:18 Androgen Receptor Sensitivity00:08:48 The Receptor Preservation Theory00:12:49 The Dangers of Staying "On"00:15:29 The Art of Cycling00:19:34 Spiritual Leaps & Personal Growth00:22:32 Life After a Brutal Divorce00:27:40 Facing Personal Tragedy00:30:45 The No-Push Parenting Style00:32:28 From Runner to Bodybuilder00:34:41 The Genetic Hyper-Response00:38:03 Muscle Memory: Fascia vs. Nuclei00:41:55 Peptides for Soft Tissue Repair00:44:21 The Struggle of Eating 12 Meals00:50:56 Don't Listen to Genetic Freaks00:53:25 The 1.5g Protein Rule00:55:17 The Reality of Aging: Height & Hair00:58:55 Carb Cycling for Performance01:01:31 Macadamia Nut Oil: The Secret Fuel01:04:04 Balancing Omega 3s and 6s01:08:03 Reclaiming Your Gut Health01:12:18 Insulin, Brain Health, & Dementia01:15:40 Debunking the Insulin-Fat Myth01:21:46 Challenging the Science01:23:55 HFT Clinics & Longevity01:26:57 The Perfect 1000mg Growth Stack01:28:41 The GLP-1 Weight Loss Revolution01:30:53 The Protein Powder Scam01:31:43 Site-Specific Peptide Injections01:33:24 The Obsession with Staying Lean01:35:59 The Downside of Year-Round GLP-101:41:45 Pharma Quality vs. Street Gear01:46:26 The Upregulation Myth Debunked01:55:11 The Bath Mate Protocol01:55:50 The McDonald's & Insulin Strategy01:59:44 IGF-1: The Light Sensitivity Secret02:04:38 Mastering the Post-Show Rebound02:06:47 Hernias & Fighting Bullies02:10:18 Free Weight Squats for Massive Legs02:13:12 Custom Orthotics: The Real Leg Hack02:15:51 Final Message: Never Quit

Angela and special guest Dr Tommy Wood explore the surprising, evidence-backed link between leg power and brain longevity. They discuss how relative leg strength acts as a primary predictor of cognitive processing speed in older adults, driven by the release of exerkines like IGF-1 which protect the brain's white matter.  They also reveal that you don't need to be an elite athlete to reap these benefits; simply reaching the top 25% of your demographic can significantly slash your risk of dementia and cognitive decline. WHAT YOU WILL LEARN Relative leg power (strength in proportion to body size) is a critical predictor of how quickly the brain processes information as we age. Strength training triggers the release of hormones like IGF-1, which are essential for maintaining the structure and insulation of the brain's white matter, You don't need infinite strength to protect your brain; reaching the top 25% to 33% of your demographic provides the most significant protection against mortality and dementia. Achieving these health benefits is possible with a modest commitment, such as two 45-minute sessions per week focusing on full-body resistance training. VALUABLE RESOURCES • Take the BioSyncing Quiz to help you understand what's actually happening in your body — and how to fix it.

Go to NutronicsLabs.com for 50% off with autoship + a FREE platinum bottle of IGF-1. Use code “MELK” for an extra 10% off! https://a.ads.rmbl.ws/link?rt=cld&id=56268&source=description   We The People must stand strong, stay united, resolute, calm, and focus on the mission. Order Mel's New Book: Americans Anonymous: Restoring Power to the People One Citizen at a Time https://themelkshow.com/book The Show's Partners Page: https://themelkshow.com/partners/ Consider Making A Donation: https://themelkshow.com/donate/ Beverly Hills Precious Metals Exchange - Buy Gold & Silver https://themelkshow.com/gold/ Speak with Gold Expert Andrew Sorchini…Tell Him Mel K Sent You! Dr. Zelenko Immunity Protocols https://zstacklife.com/MelK I trust SatellitePhoneStore when all other networks fail. With their phone, I know I'm always connected, no matter where I am or what happens. https://sat123.com/melk/ I've tried a lot of supplements over the years, but nothing has compared to the purity and results I've experienced with Chemical Free Body. USE CODE MELK Mel K Superfoods Supercharge your wellness with Mel K Superfoods Use Code: MELKWELLNESS and Save Over $100 off retail today! https://themelkshow.com/partners/ Healthy Hydration: https://themelkshow.com/partners/ Patriot Mobile Support your values, your freedom and the Mel K Show. Switch to Patriot Mobile for Free. Use free activation code MELK https://themelkshow.com/partners/ HempWorx The #1 selling CBD brand. Offering cutting edge products that run the gamut from CBD oils and other hemp products to essential oils in our Mantra Brand, MDC Daily Sprays which are Vitamin and Herb combination sprays/ https://themelkshow.com/partners/ Dr. Zelenko Immunity Protocols https://zstacklife.com/MelK Support Patriots With MyPillow Go to https://www.mypillow.com/melk Use offer code “MelK” to support both MyPillow and The Mel K Show The Wellness Company - Emergency Medical Kits: https://themelkshow.com/partners/ Dr. Stella Immanuel, MD. Consult with a renowned healthcare provider! Offering Telehealth Services & Supplements. Use offer code ‘MelK' for 5% Off https://themelkshow.com/partners/ Rumble (Video) - The Mel K Show: https://rumble.com/c/TheMelKShow X: https://twitter.com/MelKShow Twitter (Original): https://twitter.com/originalmelk TRUTH Social: https://truthsocial.com/@themelkshow Instagram: https://www.instagram.com/themelkshow/ Podbean: https://themelkshow.podbean.com/ GETTR: https://www.gettr.com/user/themelkshow Locals.com: https://melk.locals.com/ Banned Video: https://banned.video/channel/the-mel-k-show We at www.themelkshow.com want to thank all our amazing patriot pals for joining us on this journey, for your support of our work, and for your faith in this biblical transition to greatness. Together we are unstoppable. We look forward to seeing you. God Wins! https://themelkshow.com/events/ Remember to mention Mel K for great discounts on all these fun and informative events. See you there! Our Website www.TheMelKShow.com We love what we do and are working hard to keep on top of everything to help this transition along peacefully and with love. Please help us amplify our message: Like, Comment & Share!

WARNING: This episode is even longer than last week's! Settle into the back half of GDC 2026 with tales from your nice hosts about interesting talks, the "new" Festival Hall, what it feels like to be up for multiple major industry awards, running into people you know for the first time, and flying home to a impending snowstorm.In this Patreon-exclusive video, Lydia thought to mark her first GDC by capturing her first impressions of the conference's Festival Hall. Sign up at any level for instant access or, if you're not ready to enter a financial relationship with the program, you can purchase it à la carte!0:02:44GDC 2026 - (Dale's) Monday/TuesdayWeaponized Play: How Extremist Networks are Targeting Children in Online GamesKatia Potapov, Rita Fabi, Jang Kim, Jessa MelleaGame Developer ConferencePage to Booth: Table-Reading and Performance Recording Live DemoAlexa Ray Corriea, Sam Maggs, Ben Starr, Jennifer Hale, Khris Brown, Amanda Rose SmithGame Developer Conference0:09:34GDC 2026 - WednesdayRules of the Game 2026: Revealing Techniques from Resourceful DesignersGame Developer ConferenceImprov Games for Game DevelopersRez GrahamGame Developer ConferenceDecolonizing Play and the Rise of African Game Development (2013-2026)Eyram TawiaGame Developer ConferenceSerious Games RoundtableMatthew Lee, Kathleen YinGame Developer Conference'SILENT HILL f': The Challenges of Creating a Melee-Only Horror GameAl YangGame Developer ConferenceTest Like the Top Studios: Actionable Player Insights in 60 MinutesHeather De BernardiGame Developer ConferenceThe IGF 2026 Winners Are An Exceptional Selection Of Indie Games You're Going T…John WalkerKotakuTrump administration's "cruel and unnecessary" acts called out by Titanium Cour…Mark WarrenRock Paper Shotgun0:56:54GDC 2026 - ThursdayBuilding a Critically Acclaimed Licensed Game in 18 MonthsAmanda FaroughGame Developer ConferenceXbox Gaming for Everyone Community Networking Lounge Returns to GDC 2026MIcrosoftNobody Reads Anything: How Narrative Can Communicate So Other Disciplines Actua…Mark Slutsky, Laura Michet, Kevin SnowGame Developer ConferenceVeterans Q&A for New Writers and Narrative DesignersGame Developer ConferenceGaming the System: Creating Your Own Path to a Narrative Design CareerZoe Calamar, Luca Azenaro-AceroGame Developer Conference Worst.Game.Ever. Fixing Diabetes Management with a Video GameSam GlassenbergGame Developer Conference1:33:03GDC 2026 - FridayDigital Folklore: Crafting Playable Memory Through Photogrammetry and Animation…Verda MunirGame Developer ConferenceSan Francisco Railway Museum & Gift ShopThe Dialogue Design Panel: A Role with a Million NamesCharles Pateman, Kareem Shuman, Monet Gardiner, Heather Plunkard-SergeGame Developer ConferenceTop 10 Ways to Get Your Game Ready For SuccessShawn Alexander AllenGame Developer ConferenceLive Sky Sound Bath and MeditationthatgamecompanyInstagramEssential Debugging Skills for Every DeveloperRez GrahamGame Developer ConferenceExperimental Games ShowcaseGame Developer ConferenceExperimental Games Showcase DemosGame Developer Conference

We The People must stand strong, stay united, resolute, calm, and focus on the mission. Go to Nutronicslabs.com/MELK for 50% off with autoship AND a platinum bottle of IGF-1 completely free of charge. Plus you'll get an extra 10% off when you use code “MELK” Order Mel's New Book: Americans Anonymous: Restoring Power to the People One Citizen at a Time https://themelkshow.com/book The Show's Partners Page: https://themelkshow.com/partners/ Consider Making A Donation: https://themelkshow.com/donate/ Beverly Hills Precious Metals Exchange - Buy Gold & Silver https://themelkshow.com/gold/ Speak with Gold Expert Andrew Sorchini…Tell Him Mel K Sent You! Dr. Zelenko Immunity Protocols https://zstacklife.com/MelK I trust SatellitePhoneStore when all other networks fail. With their phone, I know I'm always connected, no matter where I am or what happens. https://sat123.com/melk/ I've tried a lot of supplements over the years, but nothing has compared to the purity and results I've experienced with Chemical Free Body. USE CODE MELK Mel K Superfoods Supercharge your wellness with Mel K Superfoods Use Code: MELKWELLNESS and Save Over $100 off retail today! https://themelkshow.com/partners/ Healthy Hydration: https://themelkshow.com/partners/ Patriot Mobile Support your values, your freedom and the Mel K Show. Switch to Patriot Mobile for Free. Use free activation code MELK https://themelkshow.com/partners/ HempWorx The #1 selling CBD brand. Offering cutting edge products that run the gamut from CBD oils and other hemp products to essential oils in our Mantra Brand, MDC Daily Sprays which are Vitamin and Herb combination sprays/ https://themelkshow.com/partners/ Dr. Zelenko Immunity Protocols https://zstacklife.com/MelK Support Patriots With MyPillow Go to https://www.mypillow.com/melk Use offer code “MelK” to support both MyPillow and The Mel K Show The Wellness Company - Emergency Medical Kits: https://themelkshow.com/partners/ Dr. Stella Immanuel, MD. Consult with a renowned healthcare provider! Offering Telehealth Services & Supplements. Use offer code ‘MelK' for 5% Off https://themelkshow.com/partners/ Rumble (Video) - The Mel K Show: https://rumble.com/c/TheMelKShow X: https://twitter.com/MelKShow Twitter (Original): https://twitter.com/originalmelk TRUTH Social: https://truthsocial.com/@themelkshow Instagram: https://www.instagram.com/themelkshow/ Podbean: https://themelkshow.podbean.com/ GETTR: https://www.gettr.com/user/themelkshow Locals.com: https://melk.locals.com/ Banned Video: https://banned.video/channel/the-mel-k-show We at www.themelkshow.com want to thank all our amazing patriot pals for joining us on this journey, for your support of our work, and for your faith in this biblical transition to greatness. Together we are unstoppable. We look forward to seeing you. God Wins! https://themelkshow.com/events/ Remember to mention Mel K for great discounts on all these fun and informative events. See you there! Our Website www.TheMelKShow.com We love what we do and are working hard to keep on top of everything to help this transition along peacefully and with love. Please help us amplify our message: Like, Comment & Share!

We The People must stand strong, stay united, resolute, calm, and focus on the mission. Go to Nutronicslabs.com/MELK for 50% off with autoship AND a platinum bottle of IGF-1 completely free of charge. Plus you'll get an extra 10% off when you use code “MELK” Order Mel's New Book: Americans Anonymous: Restoring Power to the People One Citizen at a Time https://themelkshow.com/book The Show's Partners Page: https://themelkshow.com/partners/ Consider Making A Donation: https://themelkshow.com/donate/ Beverly Hills Precious Metals Exchange - Buy Gold & Silver https://themelkshow.com/gold/ Speak with Gold Expert Andrew Sorchini…Tell Him Mel K Sent You! Dr. Zelenko Immunity Protocols https://zstacklife.com/MelK I trust SatellitePhoneStore when all other networks fail. With their phone, I know I'm always connected, no matter where I am or what happens. https://sat123.com/melk/ I've tried a lot of supplements over the years, but nothing has compared to the purity and results I've experienced with Chemical Free Body. USE CODE MELK Mel K Superfoods Supercharge your wellness with Mel K Superfoods Use Code: MELKWELLNESS and Save Over $100 off retail today! https://themelkshow.com/partners/ Healthy Hydration: https://themelkshow.com/partners/ Patriot Mobile Support your values, your freedom and the Mel K Show. Switch to Patriot Mobile for Free. Use free activation code MELK https://themelkshow.com/partners/ HempWorx The #1 selling CBD brand. Offering cutting edge products that run the gamut from CBD oils and other hemp products to essential oils in our Mantra Brand, MDC Daily Sprays which are Vitamin and Herb combination sprays/ https://themelkshow.com/partners/ Dr. Zelenko Immunity Protocols https://zstacklife.com/MelK Support Patriots With MyPillow Go to https://www.mypillow.com/melk Use offer code “MelK” to support both MyPillow and The Mel K Show The Wellness Company - Emergency Medical Kits: https://themelkshow.com/partners/ Dr. Stella Immanuel, MD. Consult with a renowned healthcare provider! Offering Telehealth Services & Supplements. Use offer code ‘MelK' for 5% Off https://themelkshow.com/partners/ Rumble (Video) - The Mel K Show: https://rumble.com/c/TheMelKShow X: https://twitter.com/MelKShow Twitter (Original): https://twitter.com/originalmelk TRUTH Social: https://truthsocial.com/@themelkshow Instagram: https://www.instagram.com/themelkshow/ Podbean: https://themelkshow.podbean.com/ GETTR: https://www.gettr.com/user/themelkshow Locals.com: https://melk.locals.com/ Banned Video: https://banned.video/channel/the-mel-k-show We at www.themelkshow.com want to thank all our amazing patriot pals for joining us on this journey, for your support of our work, and for your faith in this biblical transition to greatness. Together we are unstoppable. We look forward to seeing you. God Wins! https://themelkshow.com/events/ Remember to mention Mel K for great discounts on all these fun and informative events. See you there! Our Website www.TheMelKShow.com We love what we do and are working hard to keep on top of everything to help this transition along peacefully and with love. Please help us amplify our message: Like, Comment & Share!

We The People must stand strong, stay united, resolute, calm, and focus on the mission. Go to Nutronicslabs.com/MELK for 50% off with autoship AND a platinum bottle of IGF-1 completely free of charge. Plus you'll get an extra 10% off when you use code “MELK” Order Mel's New Book: Americans Anonymous: Restoring Power to the People One Citizen at a Time https://themelkshow.com/book The Show's Partners Page: https://themelkshow.com/partners/ Consider Making A Donation: https://themelkshow.com/donate/ Beverly Hills Precious Metals Exchange - Buy Gold & Silver https://themelkshow.com/gold/ Speak with Gold Expert Andrew Sorchini…Tell Him Mel K Sent You! Dr. Zelenko Immunity Protocols https://zstacklife.com/MelK I trust SatellitePhoneStore when all other networks fail. With their phone, I know I'm always connected, no matter where I am or what happens. https://sat123.com/melk/ I've tried a lot of supplements over the years, but nothing has compared to the purity and results I've experienced with Chemical Free Body. USE CODE MELK Mel K Superfoods Supercharge your wellness with Mel K Superfoods Use Code: MELKWELLNESS and Save Over $100 off retail today! https://themelkshow.com/partners/ Healthy Hydration: https://themelkshow.com/partners/ Patriot Mobile Support your values, your freedom and the Mel K Show. Switch to Patriot Mobile for Free. Use free activation code MELK https://themelkshow.com/partners/ HempWorx The #1 selling CBD brand. Offering cutting edge products that run the gamut from CBD oils and other hemp products to essential oils in our Mantra Brand, MDC Daily Sprays which are Vitamin and Herb combination sprays/ https://themelkshow.com/partners/ Dr. Zelenko Immunity Protocols https://zstacklife.com/MelK Support Patriots With MyPillow Go to https://www.mypillow.com/melk Use offer code “MelK” to support both MyPillow and The Mel K Show The Wellness Company - Emergency Medical Kits: https://themelkshow.com/partners/ Dr. Stella Immanuel, MD. Consult with a renowned healthcare provider! Offering Telehealth Services & Supplements. Use offer code ‘MelK' for 5% Off https://themelkshow.com/partners/ Rumble (Video) - The Mel K Show: https://rumble.com/c/TheMelKShow X: https://twitter.com/MelKShow Twitter (Original): https://twitter.com/originalmelk TRUTH Social: https://truthsocial.com/@themelkshow Instagram: https://www.instagram.com/themelkshow/ Podbean: https://themelkshow.podbean.com/ GETTR: https://www.gettr.com/user/themelkshow Locals.com: https://melk.locals.com/ Banned Video: https://banned.video/channel/the-mel-k-show We at www.themelkshow.com want to thank all our amazing patriot pals for joining us on this journey, for your support of our work, and for your faith in this biblical transition to greatness. Together we are unstoppable. We look forward to seeing you. God Wins! https://themelkshow.com/events/ Remember to mention Mel K for great discounts on all these fun and informative events. See you there! Our Website www.TheMelKShow.com We love what we do and are working hard to keep on top of everything to help this transition along peacefully and with love. Please help us amplify our message: Like, Comment & Share!

We The People must stand strong, stay united, resolute, calm, and focus on the mission. Go to Nutronicslabs.com/MELK for 50% off with autoship AND a platinum bottle of IGF-1 completely free of charge. Plus you'll get an extra 10% off when you use code “MELK” Order Mel's New Book: Americans Anonymous: Restoring Power to the People One Citizen at a Time https://themelkshow.com/book The Show's Partners Page: https://themelkshow.com/partners/ Consider Making A Donation: https://themelkshow.com/donate/ Beverly Hills Precious Metals Exchange - Buy Gold & Silver https://themelkshow.com/gold/ Speak with Gold Expert Andrew Sorchini…Tell Him Mel K Sent You! Dr. Zelenko Immunity Protocols https://zstacklife.com/MelK I trust SatellitePhoneStore when all other networks fail. With their phone, I know I'm always connected, no matter where I am or what happens. https://sat123.com/melk/ I've tried a lot of supplements over the years, but nothing has compared to the purity and results I've experienced with Chemical Free Body. USE CODE MELK Mel K Superfoods Supercharge your wellness with Mel K Superfoods Use Code: MELKWELLNESS and Save Over $100 off retail today! https://themelkshow.com/partners/ Healthy Hydration: https://themelkshow.com/partners/ Patriot Mobile Support your values, your freedom and the Mel K Show. Switch to Patriot Mobile for Free. Use free activation code MELK https://themelkshow.com/partners/ HempWorx The #1 selling CBD brand. Offering cutting edge products that run the gamut from CBD oils and other hemp products to essential oils in our Mantra Brand, MDC Daily Sprays which are Vitamin and Herb combination sprays/ https://themelkshow.com/partners/ Dr. Zelenko Immunity Protocols https://zstacklife.com/MelK Support Patriots With MyPillow Go to https://www.mypillow.com/melk Use offer code “MelK” to support both MyPillow and The Mel K Show The Wellness Company - Emergency Medical Kits: https://themelkshow.com/partners/ Dr. Stella Immanuel, MD. Consult with a renowned healthcare provider! Offering Telehealth Services & Supplements. Use offer code ‘MelK' for 5% Off https://themelkshow.com/partners/ Rumble (Video) - The Mel K Show: https://rumble.com/c/TheMelKShow X: https://twitter.com/MelKShow Twitter (Original): https://twitter.com/originalmelk TRUTH Social: https://truthsocial.com/@themelkshow Instagram: https://www.instagram.com/themelkshow/ Podbean: https://themelkshow.podbean.com/ GETTR: https://www.gettr.com/user/themelkshow Locals.com: https://melk.locals.com/ Banned Video: https://banned.video/channel/the-mel-k-show We at www.themelkshow.com want to thank all our amazing patriot pals for joining us on this journey, for your support of our work, and for your faith in this biblical transition to greatness. Together we are unstoppable. We look forward to seeing you. God Wins! https://themelkshow.com/events/ Remember to mention Mel K for great discounts on all these fun and informative events. See you there! Our Website www.TheMelKShow.com We love what we do and are working hard to keep on top of everything to help this transition along peacefully and with love. Please help us amplify our message: Like, Comment & Share!

In this episode of Bathroom Diaries, I sit down again with Dr. Rob Frankel to talk about something most people have never heard of — somatopause. We talk a lot about menopause and andropause. But there is another hormonal shift that affects both men and women starting as early as their 30s: the gradual decline in growth hormone. This conversation is Part 4 of my Peptide Playbook series, where we explore how growth hormone signaling changes over time, why IGF-1 testing matters, and how peptides like tesamorelin, CJC-ipamorelin, and sermorelin may support the body's own natural growth hormone production.  In this episode, we discuss: ✨ What somatopause actually is ✨ Why IGF-1 is the most useful marker to evaluate growth hormone decline  ✨ How muscle loss, fat gain, fatigue, poor sleep, and brain fog may be connected ✨ The role of growth hormone analog peptides ✨ Why sleep quality and sugar intake affect nighttime hormone release ✨ How GLP-1 therapies support metabolic health and hormone balance ✨ The connection between fatty liver, insulin resistance, and longevity ✨ Who is (and is not) a candidate for peptide-based support ✨ The real clinical studies behind these therapies My goal with this series is simple: to demystify longevity medicine and bring medically responsible conversations about peptides into the open — so patients can make informed decisions with qualified physicians. Somatopause is rarely discussed, but understanding it can change how we think about aging, metabolism, cognition, and strength across the lifespan. If you're interested in hormone optimization, peptide therapy, or proactive aging strategies, this episode is for you. 00:00 Introduction – What is Somatopause? 02:05 Why Growth Hormone Declines After Age 30 04:10 IGF-1 Explained: The Best Marker for Growth Hormone  07:05 Symptoms of Somatopause (Muscle Loss, Fat Gain, Memory Changes) 10:20 Why Doctors Rarely Test Growth Hormone 13:05 Growth Hormone vs Growth Hormone Analogs  16:10 Tesamorelin, CJC-Ipamorelin & Sermorelin Explained 19:15 Are Growth Hormone Peptides Safe? 22:10 Growth Hormone Use in Athletes – What's Appropriate? 25:00 Why Peptides Are Cycled (Receptor Sensitivity Explained) 28:05 Sleep, Sugar & Somatostatin: Hidden Hormone Blockers 31:10 How Sugar Reduces Growth Hormone Production 33:20 GLP-1 Medications & Their Role in Hormone Optimization 36:15 Fatty Liver, Insulin Resistance & Longevity Risk 39:20 Tesamorelin Study: Reducing Visceral Fat by 40% 42:05 Traumatic Brain Injury Study & Growth Hormone Deficiency 45:00 Memory, Cognition & Executive Function Improvements  47:15 Who Should NOT Take Growth Hormone Peptides 49:05 Cost of Growth Hormone Analog Therapy 51:10 Best Blood Tests to Evaluate Somatopause (IGF-1 & Fasting Insulin) 53:00 Final Thoughts: Why Somatopause Matters for Longevity

In this livestream, Scott McNally breaks down a powerful perspective from a medical doctor who is also a bodybuilder and PED user — sharing how to actually work with your doctor instead of against them. If you've ever been frustrated trying to get bloodwork, labs, or testing ordered, this episode explains why doctors push back — and more importantly, how to approach the conversation so you get taken seriously. Learn how to communicate your concerns, understand the system doctors operate in, and increase your chances of getting the testing you need as an enhanced athlete. After the main topic, Scott opens the floor to a full live Q&A covering bodybuilding, PEDs, diet, training, and more. If you're serious about your health and progress, this is a must-watch. Chapters 0:00 Welcome to the Live Stream | Scott McNally 1:30 What We're Covering Today (Labs + Live Q&A) 3:40 Who is Scott McNally? (Coaching & Background) 5:00 How to Get Bloodwork Through Your Doctor 9:30 Why Insurance Controls Your Lab Work 11:00 The Hidden Risks of Over-Testing (False Positives, Complications) 13:15 Why Doctors Don't Treat You Like a Customer 14:30 How to Talk to Your Doctor (What Actually Works) 16:30 Symptoms vs Strategy: What Doctors Look For 18:00 Feeling Heard vs Getting What You Want 19:15 Private Labs & Paying Out of Pocket 22:20 Best Health Markers to Check Mid Cycle 28:00 Can You Build Muscle While Dieting? (IGF-1 Explained) 32:00 E2 vs Sensitive Estradiol Test (What Matters) 33:00 Managing Estrogen on TRT (How Clearance Works) 38:00 Does TRT Between Cycles Restore Health Markers? 39:45 Testosterone Use for Wheelchair Athletes 44:15 Does More Than TRT Improve Muscle Gains? 47:45 Is Scott Into Motorsports? (Personal Q&A) 49:30 How to Introduce Fast-Acting Insulin Safely 54:30 Using Fast-Acting Insulin During a Cut 57:30 Taper Up or Jump to Full Cycle Doses? (Test + Deca) 1:00:30 Are Mini Cuts Worth It in the Offseason? 1:04:45 How to Titrate from TRT to Cycle Doses 1:08:00 How High Can Hematocrit Go Safely? 1:15:00 Site Enhancement Oils: Old School vs Hyaluronic Acid 1:29:18 Scott's Acne Story 1:33:15 Can More Insulin Overcome Insulin Resistance? 1:35:15 Broken Bone While Cutting: How to Adjust Your Diet 1:43:00 How to Shrink Your Waist & Improve Midsection 1:56:00 Supplement Unboxing (Live) 1:59:00 How Low Can You Take Protein? 2:04:45 Does Growth Hormone Cause Hyperplasia? 2:05:15 Why Fast Food Is So Expensive Now 2:08:00 The IGF-1 Trade-Off Explained 2:12:25 Do Organs Grow on GH? (Myth vs Reality) 2:14:00 Clenbuterol & Cardio Timing (Best Approach) 2:22:00 High Dose Cialis: Is It Safe or Effective? 2:23:00 SLU-PP-332 for Chronic Fatigue (Does It Work?) 2:24:00 Shoutout to the Community (Appreciation) 2:27:30 Be Careful What Media You Consume Reach out to Scott for coaching or consultations : mcnallydiets@gmail.com

If you want to get leaner and live longer check out https://milliondollarbodylabs.com Have you ever been sidelined by an injury and wondered if there was a way to bypass the "Netflix and chill" recovery method to heal 30% faster?   I put together a compilation to show how to bulletproof your body. I talk with Michael Roviello about baths and fat. He explains how therapy helps mitochondria. Gary Brecka discusses how oxygen prevents disease and warns against the pathway of injuries. I explain how restriction training triggers hormones. I demonstrate using bands for compression to flush waste and I also detail using a ball to release spasms. These methods help you recover from surgery or pain without relying on ibuprofen. Key Takeaways Ice baths trigger a nervous system shift that reduces inflammation and can induce a meditative state through theta brainwaves. Brown fat acts as a thermogenesis process that converts visceral fat into heat when the body is exposed to cold environments. Mitochondrial function is the core of optimal health, and it can be improved through red light therapy and cold shock proteins. Blood Flow Restriction (BFR) training can speed up recovery by 30% by inducing a hormonal cascade of HGH and IGF-1. The presence of oxygen is the absence of disease, as hypoxia is at the root of nearly every major health issue. Voodoo bands provide mechanical compression to flush out waste products and reestablish full range of motion in joints. Contrast therapy creates a "pump effect" in blood vessels by alternating between hot and cold to move nutrients to injured areas. Resources  Nate Palmer: The founder of The Million Dollar Body and author of "The Million Dollar Body Method", Nate has been coaching for over 15 years and has worked personally with over 1,000 clients.   Website: https://milliondollarbodylabs.com Book: The Million Dollar Body Method Lean Energy Stack: https://milliondollarbodylabs.com/pages/lean Instagram: @_milliondollarbody

In this Episode, Ian once again joins the clubhouse as Dale and Mark are off on a nerdy vacation. Lydia wrestles with the term "cozy," and Stephen does some self exploration to determine why so-called cozy games make him more stressed out. Then, he creates a whole topic just to talk about the fast travel system in Dragon's Dogma 2.Stephen pitched Sledgehammer Bride to Melanated Games Kitchen.Melanated Game KitchenThe clubhouse hosted a Nice Thinking episode about Sledgehammer bride back in episode 240 Nice Thinking: "Sledgehammer Bride"Lydia and Ian went to Con of the NorthCon of the NorthLydia and Ian are playing Blippo+Mark was a developer on the PC version of Blippo+ which is a 2026 IGF award finalist.Blippo+0:09:15Cozy Games0:38:26Fast TravelDragon's Dogma 2

We The People must stand strong, stay united, resolute, calm, and focus on the mission. Go to Nutronicslabs.com/MELK for 50% off with autoship AND a platinum bottle of IGF-1 completely free of charge. Plus you'll get an extra 10% off when you use code “MELK” Order Mel's New Book: Americans Anonymous: Restoring Power to the People One Citizen at a Time https://themelkshow.com/book The Show's Partners Page: https://themelkshow.com/partners/ Consider Making A Donation: https://themelkshow.com/donate/ Beverly Hills Precious Metals Exchange - Buy Gold & Silver https://themelkshow.com/gold/ Speak with Gold Expert Andrew Sorchini…Tell Him Mel K Sent You! I trust SatellitePhoneStore when all other networks fail. With their phone, I know I'm always connected, no matter where I am or what happens. https://sat123.com/melk/ I've tried a lot of supplements over the years, but nothing has compared to the purity and results I've experienced with Chemical Free Body. USE CODE MELK Mel K Superfoods Supercharge your wellness with Mel K Superfoods Use Code: MELKWELLNESS and Save Over $100 off retail today! https://themelkshow.com/partners/ Healthy Hydration: https://themelkshow.com/partners/ Patriot Mobile Support your values, your freedom and the Mel K Show. Switch to Patriot Mobile for Free. Use free activation code MELK https://themelkshow.com/partners/ HempWorx The #1 selling CBD brand. Offering cutting edge products that run the gamut from CBD oils and other hemp products to essential oils in our Mantra Brand, MDC Daily Sprays which are Vitamin and Herb combination sprays/ Support Patriots With MyPillow Go to https://www.mypillow.com/melk Use offer code “MelK” to support both MyPillow and The Mel K Show The Wellness Company - Emergency Medical Kits: https://themelkshow.com/partners/ Dr. Stella Immanuel, MD. Consult with a renowned healthcare provider! Offering Telehealth Services & Supplements. Use offer code ‘MelK' for 5% Off https://themelkshow.com/partners/ Rumble (Video) - The Mel K Show: https://rumble.com/c/TheMelKShow X: https://twitter.com/MelKShow Twitter (Original): https://twitter.com/originalmelk TRUTH Social: https://truthsocial.com/@themelkshow Instagram: https://www.instagram.com/themelkshow/ Podbean: https://themelkshow.podbean.com/ GETTR: https://www.gettr.com/user/themelkshow Locals.com: https://melk.locals.com/ Banned Video: https://banned.video/channel/the-mel-k-show We at www.themelkshow.com want to thank all our amazing patriot pals for joining us on this journey, for your support of our work, and for your faith in this biblical transition to greatness. Together we are unstoppable. We look forward to seeing you. God Wins! https://themelkshow.com/events/ Remember to mention Mel K for great discounts on all these fun and informative events. See you there! Our Website www.TheMelKShow.com We love what we do and are working hard to keep on top of everything to help this transition along peacefully and with love. Please help us amplify our message: Like, Comment & Share!

Tesamorelin is one of the most talked-about peptides for fat loss, growth hormone support, and metabolic health—but is it actually safe and effective? In this episode of The Health Revival Show, we break down how tesamorelin works in the body, its impact on visceral fat reduction, IGF-1, insulin resistance, and recovery, plus the real side effects no one talks about. We also cover dosing strategies, cycling protocols, and why peptides should never be your starting point. If you're struggling with stubborn belly fat, poor metabolic health, or considering peptides—this is a must-listen. *** CONNECT:

Go to NutronicsLabs.com for 50% off with autoship + a FREE platinum bottle of IGF-1. Use code “MELK” for an extra 10% off! https://a.ads.rmbl.ws/link?rt=cld&id=54200&source=description   We The People must stand strong, stay united, resolute, calm, and focus on the mission. Order Mel's New Book: Americans Anonymous: Restoring Power to the People One Citizen at a Time https://themelkshow.com/book The Show's Partners Page: https://themelkshow.com/partners/ Consider Making A Donation: https://themelkshow.com/donate/ Beverly Hills Precious Metals Exchange - Buy Gold & Silver https://themelkshow.com/gold/ Speak with Gold Expert Andrew Sorchini…Tell Him Mel K Sent You! I trust SatellitePhoneStore when all other networks fail. With their phone, I know I'm always connected, no matter where I am or what happens. https://sat123.com/melk/ I've tried a lot of supplements over the years, but nothing has compared to the purity and results I've experienced with Chemical Free Body. USE CODE MELK Mel K Superfoods Supercharge your wellness with Mel K Superfoods Use Code: MELKWELLNESS and Save Over $100 off retail today! https://themelkshow.com/partners/ Healthy Hydration: https://themelkshow.com/partners/ Patriot Mobile Support your values, your freedom and the Mel K Show. Switch to Patriot Mobile for Free. Use free activation code MELK https://themelkshow.com/partners/ HempWorx The #1 selling CBD brand. Offering cutting edge products that run the gamut from CBD oils and other hemp products to essential oils in our Mantra Brand, MDC Daily Sprays which are Vitamin and Herb combination sprays/ https://themelkshow.com/partners/ Dr. Zelenko Immunity Protocols https://zstacklife.com/MelK Support Patriots With MyPillow Go to https://www.mypillow.com/melk Use offer code “MelK” to support both MyPillow and The Mel K Show The Wellness Company - Emergency Medical Kits: https://themelkshow.com/partners/ Dr. Stella Immanuel, MD. Consult with a renowned healthcare provider! Offering Telehealth Services & Supplements. Use offer code ‘MelK' for 5% Off https://themelkshow.com/partners/ Rumble (Video) - The Mel K Show: https://rumble.com/c/TheMelKShow X: https://twitter.com/MelKShow Twitter (Original): https://twitter.com/originalmelk TRUTH Social: https://truthsocial.com/@themelkshow Instagram: https://www.instagram.com/themelkshow/ Podbean: https://themelkshow.podbean.com/ GETTR: https://www.gettr.com/user/themelkshow Locals.com: https://melk.locals.com/ Banned Video: https://banned.video/channel/the-mel-k-show We at www.themelkshow.com want to thank all our amazing patriot pals for joining us on this journey, for your support of our work, and for your faith in this biblical transition to greatness. Together we are unstoppable. We look forward to seeing you. God Wins! https://themelkshow.com/events/ Remember to mention Mel K for great discounts on all these fun and informative events. See you there! Our Website www.TheMelKShow.com We love what we do and are working hard to keep on top of everything to help this transition along peacefully and with love. Please help us amplify our message: Like, Comment & Share!

EPISODE DESCRIPTION The industry lied to you: performance isn't built on a squat rack—it's engineered at the cellular level. Most coaches are guessing with your biology, while Anthony Castore has spent thirty years proving them wrong. Before becoming the bridge between elite medicine and the weight room, Castore was a student of the "Old Guard," forged in the high-stakes environments of Westside Barbell and mentored by legends like John Meadows and Charles Poliquin. He didn't just learn strength—he witnessed the systemic breakdown of high performers following conventional methods. This obsession with why the body fails—and how to make it more resilient—led him away from traditional coaching and into the deep science of SSRP protocols. The shift wasn't just about moving more weight—it was about mastering the invisible metrics of electron flow and redox balance. Castore identified the gap between medical diagnosis and peak performance—a gap where most athletic careers stall. If your cellular "factory" is compromised, adding more training stress only accelerates breakdown. INSIDE THE EPISODE The Energy Crisis: Why your perceived lack of oxygen during training may actually be a failure in ATP production—and how your chemoreceptors can mislead you The Peptide Hierarchy: Moving beyond the "natty vs enhanced" debate to understand how bioregulators influence gene expression The "Shadow" Deficiencies: Why standard bloodwork often misses mitochondrial dysfunction that limits fat loss and strength The Protocol Paradox: Why the same peptide can help one athlete and harm another based on autonomic regulation The 24-Hour Blueprint: From journaling and nervous system inputs to precise timing of compounds like Tesamorelin and IGF-1 MEET THE GUEST: ANTHONY CASTORE Anthony Castore is an SSRP Fellow and widely recognized as the "King of Peptides," operating at the intersection of body composition, longevity, and cellular efficiency. With over 30 years of experience working alongside leaders like Dr. Eric Serrano and Westside Barbell, Castore has moved beyond traditional training. He specializes in recalibrating human biology—helping high performers fix underlying dysfunction and optimize performance at the cellular level. SUPPORT THE PODCAST Become an elitefts channel member for early access to Dave Tate's Table Talk podcast and exclusive perks: ➡️ @eliteftsofficial FULL Crew Access: https://www.elitefts.com/join-the-crew Limited Edition Apparel: https://www.elitefts.com/shop/apparel/limited-edition.html Programs & More: https://www.elitefts.com/shop/dave-tate-s-table-talk-crew.html TYAO Application: https://www.elitefts.com/dave-tate-s-tyao-application BEST-SELLING ELITEFTS PRODUCTS Pro Resistance Training Bands: https://www.elitefts.com/shop/bands.html Specialty Barbells: https://www.elitefts.com/shop/bars-weights/specialty-bars.html Wraps, Straps, Sleeves: https://www.elitefts.com/shop/power-gear.html SPONSORS Get an extra 10% OFF at elitefts (CODE: TABLE TALK): https://www.elitefts.com/ Get 10% OFF Marek Health Labs (CODE: TABLETALK): https://marekhealth.com/tabletalk Get a free 8-count sample pack of LMNT drink mix: http://www.drinklmnt.com/tabletalk Support Massenomics: https://www.massenomics.com/ Save 20% on MASS Research Review (CODE: ELITEFTS20): https://massresearchreview.com/ Get 10% OFF RP Hypertrophy App (CODE: TABLE TALK): https://rpstrength.com/pages/hypertrophy-app

Dr Deb Muth 00:03Well, welcome back to Let’s Talk Wellness Now. I am your host, Dr. Deb. And what is the most talked-about peptides in functional medicine? aren’t actually FDA approved. Not because they don’t work, but because no one’s funded the research to prove it yet. The truth is, some of the compounds that dominate wellness forums, BPC-157, TB-500, thymosin beta-4, epitalin, occupy a fascinating space between breakthrough science and unregulated experimentation. In today’s episode, we’re stepping into that grey zone, the world of investigational peptides, to separate mechanism from marketing. I’m going to walk you through the science that actually shows and where it stops, how to evaluate claims when human data don’t yet exist, and the quality, purity, and safety red flags that you need to recognise. Dr Deb Muth 01:06I created it in a previous episode, so go check that one out. And why honesty is the most important prescription in peptide medicine. If you’ve ever wondered whether these research-only peptides are the frontier of healing or the next functional medicine fad, this episode is for you. So grab your cup of tea or coffee, get comfortable, and let’s talk about what it really means to use peptides that are promising but still under investigation. So we’re going to break just for a second here and have a word from our sponsor. It is because of them that we stay on the air. So thank you for this. And we will be right back. Did you know sweating can literally heal your cells? Infrared saunas don’t just relax you. They detox your body, balance hormones, and boost mitochondrial energy. I’m obsessed with my Health Tech sauna. And right now, you can save $500 with my code at healthtechhealth.com slash dr-muth-req-25. Dr. Deb Muth 02:15All right, guys, welcome back. Let’s dive into investigational peptides, the evidence gap. So the following peptides we’re about ready to discuss are extensively in integrative, functional, and regenerative medicine circles. They may have intriguing mechanisms and promising preclinical data. However, they lack FDA approval, and the evidence quality varies dramatically. from interesting preliminary research to essentially no human data at all. And this distinction is really critical for maintaining scientific integrity. So let’s talk about immune-modulating peptides. There’s thymus and alpha-1, and this is an international story on the thymic peptides. Thymusin alpha-1, known as TA1, is marketed internationally as zidaxin. Dr. Deb Muth 03:16It’s a 28-amino acid polypeptide originally isolated from thymusin fraction 5, which was extracted from bovine thymus tissue. Modern production uses synthetic peptide synthesis. The thymus gland is located behind the sternum and is the primary site for T cell maturation, and thymic peptides like TA1 play roles in human system development and regulation. Now, I love thymus peptides. I love thymus glandular products. I’ve used thymus glandular products for decades. Ground-up animal thymus gland is basically what it is. There are a couple of different supplement companies that I’ve used over the years that are amazing with this. And they do a fantastic job, and they really do help to support the immune system. So when thymus peptides came out, it was really exciting because it took the whole idea of thymus support to a new level. Dr. Deb Muth 04:17The mechanism actually behind the thymus in alpha-1 is complex and involves multiple aspects of immune function. At the cellular level, TA1 enhances T cell maturation and differentiation, particularly the development of helper T cells and cytotoxic T cells. It modulates T cell receptor expression and can influence the balance between Th1 cell-mediated immunity and Th2 humoral immunity responses. And it also enhances the natural killer cell activity and modulates dendritic cell function, which are critical for antigen presentation. and initiation of adaptive immune responses. And on the cytokine level, TA1 influences production of interleukin-2, IL-2, interferon gamma, IFN-γ, and interleukin-10, IL-10. Dr. Deb Muth 05:19These create immune modulatory rather than simple immune stimulatory effects. This is a very important distinction because TA1 appears to help balance the immune system rather than simply ramping this up, which theoretically makes it safer in conditions where immune overstimulation would be a problem, such as an autoimmune disease. Hashimoto’s, autoimmune, lupus, Sjogren’s, any of those autoimmune diseases, we don’t want to overstimulate their immune system. So you want to use a product like this that’s non-stimulating. Now, the regulatory status on TA1 is geographically variable and represents one of the challenges in discussing this peptide with patients. It is not FDA-approved in the United States. However, it is approved in several other countries for specific conditions. Dr. Deb Muth 06:19In Italy, it’s approved for the treatment of chronic hepatitis B and hepatitis C. In China, it’s approved for chronic hepatitis B and adjunct immune compromised patients receiving vaccinations or suffering from certain infections. It has an orphan drug designation in the United States for certain cancer indications, but its designation does not constitute approval. It simply provides regulatory incentives for further development. So the evidence base for thymosin alpha-1 is substantial in some areas but comes primarily from non-US populations and research groups, which creates challenges in evaluating quality and generalizable information. So in hepatitis B and C, multiple clinical trials, many conducted in China and Italy, have examined TA1 as an adjunct to antiviral therapy. Dr. Deb Muth 07:21A meta-analysis by Wu and colleagues published in the Journal of Viral Hepatitis in 2013 examined 23 randomized controlled trials, including over 2,000 patients with chronic hepatitis B. The analysis found that combining TA1 with nucleoside analogs like LAMVDUDE or an and TCAVAR improved the hepatitis antigen seroconversion rates by HBV DNA clearance compared to its nucleoside analogs alone. And the effect sizes were modest but statistically significant, with the HBE-AG seroconversion rates improving from about 24% with antivirals alone to 38% in combined therapy. Now in hepatitis C, early trials before the development of direct-acting antivirals showed that TA1 combined with interferon alpha improved sustained virological responses, and compared to interferon alpha, Dr. Deb Muth 08:30Furon alone, particularly in difficult-to-treat populations like those with a genotype one or a high viral load. However, the advent of highly effective direct acting antivirals that achieve SRV rates, sorry, SVR rates exceeding 95%, the role of TA1 in hepatitis C has become less clear. Now in sepsis and critical illness, more recent interest has focused on TA1 in severe cases of sepsis and septic shock. Ren and colleagues published a systematic review and meta-analysis in the Frontiers of Immunology in 2022, analyzing 18 randomized controlled trials, including 1787 patients with severe sepsis or septic shock the pooled analysis showed that ta1 administration was associated with reduced 28-day mortality relative risk at 0.70 meaning a 30 reduction in mortality compared to the standard care alone and the effect appeared Dr. Deb Muth 09:39most pronounced in patients with sepsis-induced immunosuppression measured by HLA-DR expression in monocytes. Now, this is amazing because going forward, we’re going to talk about something that’s commonly known as cytokine storm. Now, cytokine storm really became apparent since 2020 with the viral infection that we’re dealing with in the world today. But they were already looking at this kind of cytokine storm produced by sepsis or sepsis-induced immunosuppression. And it triggered this hyperinflammatory response called the cytokine storm. And many patients who survived the initial phase of the immune suppressed stata, characterized by a T cell exhaustion, reduced antigen presentation, and increased susceptibility to secondary infections. Thymusin alpha-1, TA1, may help restore this immune competence in this phase. However, it’s important to note that patient selection and timing are critical. Dr. Deb Muth 10:43Giving this immune stimulant during a hyperinflammatory phase could theoretically worsen outcomes. So you don’t want to give it to them while they’re in the flare up or the sepsis or the infection, but given to them during the immunosuppression phase afterwards might be beneficial. Now there is also some cancer immunotherapy that we see with TA1 and has been studied as an adjunct in cancer treatment with the hypothesis that it could enhance immune surveillance and response to tumors. And a comprehensive review of Garci and colleagues published in Expert Opinion on Biological Therapy in 2007 examined multiple trials in melanoma, lung cancer, hepatocellular carcinoma, and other malignancies. And the results were mixed. Some trials showed improvement in the immune parameters, increased CD4 in T-cells. improved lymphocyte proliferation responses and some actually showed trends toward improved progression free survival but overall survival benefits were inconsistent and the heterogeneity of the cancer types treatment protocols and outcome measures makes a definitive conclusion difficult as a vaccine adjunct several studies particularly from china have examined ta1 as an adjunct to enhance vaccine responses Dr. Deb Muth 12:11in immune-compromised populations, including the elderly, dialysis patients, and transplant recipients. The rationale is sound. These populations often mount suboptimal antibody responses to vaccines, and TA1’s immune-enhancing effects might improve protection. There are small trials. They have shown improvement in seroconversion rates of hepatitis B vaccines and influenza vaccine in these populations. And though large-scale confirmatory studies are limited, there is a possibility here. Now, on their safety profile, one of the appealing aspects of thymusin alpha-A TA1 is that it’s apparently favorable safety profile in clinical trials. There are some injection site reactions with a little redness, a mild discomfort, and most commonly reported adverse effects. is that their severe adverse events attributable to TA1 have been rare in published trials. However, comprehensive long-term safety data are limited Dr. Deb Muth 13:13And theoretically, concern exists that immune modulation could potentially trigger or exasperate autoimmune conditions in susceptible individuals. Though this hasn’t been clearly demonstrated in clinical trials, integrative medicine considerations for integrative practitioners concerning the thymus and alpha-1, several factors require careful thought. First, sourcing and quality control are critical concerns. Since it’s not FDA approved, TA1 available in the United States typically will come from a compounding pharmacy or an international supplier with variable quality assurance. And pharmaceutical grade product with certificates of analysis showing purity, sterility, and endotoxin testing is essential, but it is readily available from many of these companies. Second, patient selection matters immensely. TA1 should be considered in complex cases where conventional approaches have been insufficient, such as chronic viral infections not responding adequately Dr. Deb Muth 14:21to standard antivirals, post-viral syndromes with evidence of immune dysfunction, cancer patients with immune suppression in consultation with oncology, and it should generally be avoided in active autoimmune disease unless there’s a compelling rationale and close monitoring. Now, TA1 is not a standalone therapy. In cases of chronic viral infection, Comprehensive immune support includes addressing nutritional deficiencies, optimizing vitamin D levels to be between 50 and 80, adequate zinc, selenium, and vitamin A, optimizing gut health since 80% of our immune function is in the gut, you need to optimize gut function. Managing stress from the HPA access dysfunction, chronic cortisol elevation, suppression, and immunity, ensuring adequate sleep, immune memory consolidations during sleep, addressing any metabolic dysfunction, insulin resistance, repairs in the immune function, and the bottom line on thymus and alpha-1 is Dr. Deb Muth 15:26is that it represents legitimate medicine in other countries with a substantial evidence base in specific contexts, but it remains experimental in the U.S., and practitioners using it should provide comprehensive, informed consent about its regulatory status, evidence quality, and source verification. while ensuring it’s part of comprehensive protocols. It is not a magic bullet. And again, what you’re gonna hear me say quite often here is that many of these peptides should be used in conjunction with something else. They should not be used alone. And can peptides be stacked? The answer is yes, they can. So if somebody has an insulin resistance, or a metabolic dysfunction, they can tier TA1 with a GLP-1 like terzepatide or semiglutide. That is not a problem to do that. You need to just work with a practitioner that understands how to do that effectively. So let’s look at BPC-157. Dr. Deb Muth 16:26This is a phenomenon I love BPC-157. Let’s separate it from marketing to actual mechanism of actions here. So BPC-157 stands for Body Protection Compound 157. It is a chain of 15 amino acids that are described as a partial sequence of body protection compound, a protein found in human gastric juice. It has become one of the most hyped peptides in regenerative medicine inside the athletic performance and biohacking communities with claims ranging from healing tendons and ligaments to repairing gut lining or reversing organ damage. The challenge is separating the legitimate mechanisms of science from the marketing hype. The proposed mechanism of BPC-157 are biologically plausible and intriguing. The research suggests that it may influence several growth factor pathways, including vascular endothelial growth factor, VEGF, which promotes new blood vessel formation and has improved better supply of blood flow to injured tissues, theoretically accelerating healing. Dr. Deb Muth 17:40It may also affect fibrous blast growth factor, FGF, and transforming growth factor beta, TGF beta pathways. both involved in tissue repair and remodeling. And some studies actually suggest that BPC-157 modulates inflammatory cascades, potentially reducing excessive inflammation while promoting the resolution phase that allows tissue rebuilding. Now I want to talk just a few moments here about these different tests that we’re talking about tgf beta veg f for those of you who are in our mold world you are very familiar with these uh lab tests we do this to see if you have a mold exposure what’s happening to your body and it’s been very challenging to try to heal this part of the mold illness and manipulate these VEGFs and TGF betas. And so with the fact that BPC helps us modulate this inflammatory cascade, BPC can be very helpful in the world of mold or mycotoxin illness in repairing those parts of the body that have been damaged by the mycotoxins. Dr. Deb Muth 18:48Now there is animal research on BPC-157. It is extensive and primarily from a research group led by pre-drag, oh, I can never say these names, Cyrek at the University of Zagreb in Croatia. Published studies in animal models have shown accelerated healing in a remarkable variety of injury types. A 2011 paper by Chang and colleagues in the Journal of Applied Physiology demonstrated that BPC-157 improved therapy tendon healing in rats with Achilles tendon injuries, and the treated rats showed increased tendon outgrowth, better cell survival in the injured area, enhanced cell migration to the injury site, and improved biochemical strength of the healed tendon compared to controls. Multiple other animal studies have shown similar promising effects. Ligament tears, healing faster in rabbits, muscle damage recovering more quickly in rodent models, gastric ulcers healing in rats given experimental induced ulcerations, inflammatory bowel lesions improving in mouse models of colitis, and even bone to tendon healing showing enhancement in animal studies. Dr. Deb Muth 20:02The breadth of injury types showing benefit in preclinical models explains the enthusiasm of this peptide. However, this is critical. These animal studies, primarily in rodents and rabbits, animal models of injury healing don’t reliably translate to human clinical outcomes. And the doses used in these animal studies when converted to human equivalent doses vary widely. And optimal human dosing is completely unknown at this point. it is all considered experimental and perhaps most importantly there are essentially no peer-reviewed controlled clinical trials in human published in humans published in major medical journals in a 2001 review of arthroscopy and the journal of arthroscopic and related surgery specifically examined in the evidence of bpc 157 and other peptides in musculoskeletal medicine The authors concluded bluntly that BPC-157 lacks evidence from randomized controlled trials and has an unknown safety profile in humans. Dr. Deb Muth 21:09 They emphasized that the jump from animal data to recommending peptides for humans use bypasses the fundamental requirement for Phase I safety studies, Phase II dose-finding studies, and Phase III efficacy trials that would establish whether BPC-157 actually works in humans and whether or not it’s safe. The absence of human safety data is particularly concerning given BPC-157’s proposed mechanisms. Peptides that influence growth factor signaling and angiogenesis could theoretically have off-target effects. Uncontrolled angiogenesis, for instance, is a hallmark of cancer progression. Tumors require blood vessel formation to grow beyond a certain size. And while there’s no evidence that BPC 157 promotes cancer, The complete absence of long term human safety studies means we simply don’t know. This isn’t fear mongering. It’s acknowledging uncertainty and uncertainty exists and understanding that if you’re choosing to use peptides like BPC 157, you are doing it in an experimental model. Dr. Deb Muth 22:17We’re experimenting with the doses that are being used. And there is potential for it to cause cancer cells in your body to grow. And you need to be aware of this and understand the risks that you’re taking when you’re using an investigational or off label use peptide. Now, quality control issues with BPC also exist. It’s not FDA approved for any indication in the US. It’s not approved in any major regulatory jurisdiction worldwide. It’s marketed as a research chemical explicitly to bypass FDA oversight. And commercial sources selling BPC-157 range from compounding pharmacies, which have some quality standards but are not FDA inspected. You can take that for what you want to believe on that one. to overseas suppliers operating with absolutely no quality assurance whatsoever. If you are choosing to use BPC-157, you have to understand who’s manufacturing it for you, where you are getting it from, how pure it is. Dr. Deb Muth 23:26You want to make sure that you have the certificate of analysis and that it does not contain bacterial endotoxins that can contaminate the peptide or degrade the peptide and cause other issues for you. So when you talk about peptides with patients regarding BPC-157 or if you’re listening to this and you’re already using BPC-157 or other peptides, that are quote-unquote not for human consumption, an evidence-based response acknowledges both the appeal and the limitations. And you want to talk about the animal data that’s definitely showing some progress and some potential, but we don’t know what we don’t know in humans. If people are willing to take that risk, that is up to them to do that. But using BPC right now is experimental and people need to be aware of that. Are there evidence-based alternatives for patients with tendon or ligament injuries? Dr. Deb Muth 24:26And there are. There’s PRP, which has been studied in multiple randomized controlled trials. for conditions like lateral epicondylitis, tennis elbow, Achilles issues, patellar issues, knee issues. However, I want to caution you on this too. So the study that was done by Cox and colleagues in muscles, ligaments, and tendons in the Journal of 2014 showed modest benefits in pain and function compared to controls. And though the effects vary by injury type, PRP preparations can be helpful. You have to understand that a lot of times when people are doing PRP injections in their office, they are not doing it exactly the same way it was done in the study. And not to mention, if you’re using your own PRP to heal a ligament or a tendon or help your arthritis and you’re 60 or 70 years old, That is not good quality protein rich plasma. It is old protein rich plasma. And you’re not going to see necessarily the same benefits that you would see if you were using placental tissue or umbilical tissue. Dr. Deb Muth 25:33You also want to address the nutritional deficiencies or support that’s needed for connective tissue healing. And these are collagen peptides dosed at 15 grams a day. And this has been shown in a study by Shaw and colleagues in the American Journal of Clinical Nutrition in 2017 to augment collagen synthesis when combined with intermittent loading. Vitamin C is also an essential cofactor for collagen production and stabilization of collagen structure at a dose of around 500 to 1000 milligrams a day to support this process. You also need to have good adequate intake of copper and zinc. These are cofactors in collagen. Silica is also important. This comes from horsetail extract. This provides additional support as well. So more importantly, I think remembering that rehabilitation matters as well. Doing these protocols without doing some rehab is not going to get you where you want to go. Dr. Deb Muth 26:33There’s a research study by Alfredson and others for Achilles tendinopathy using the control lengthening of muscle tendon units under load to promote tendon remodeling and healing. These protocols have solid evidence and cost nothing beyond professional guidance from a physical therapist. They are important for patients seeking cutting edge regenerative approaches. Stem cell therapies, growth factors, concentrates derived from patients’ own tissues like PRP. These have a lot of good endogenous materials and they have good safety profiles. BPC-157 represents the perfect example of how promising Preclinical science gets marketed far beyond the evidence and it may eventually prove to be valuable. I think it will. But right now that determination does require some human studies and hopefully with the administration that we have right now and Bobby Kennedy, we will actually start to see some of that occur. Now the next peptide I want to talk about is TB4, thymus and beta-4. Dr. Deb Muth 27:36This is a wound healing peptide. It is a 43 amino acid peptide that’s naturally present in virtually all human cells except red blood cells. It’s actually one of the most abundant peptides in the human body, particularly concentrated in blood platelets, wound fluid, and many tissues. It’s naturally ubiquity makes it mechanistically interesting. The body wouldn’t produce it in such abundance if it didn’t serve a function. So the primary role of TB4 involves building G-actin. It’s a form of monomeric actin. And it’s structural protein that forms the microfilaments within the cells, providing cellular structure and enabling cell movement. TB4 prevents from F-actin filaments. I’m not going to talk too much about this. It’s really critical for wound healing as cells need to migrate into the injury sites. Dr. Deb Muth 28:37so the cell shape changes and the cellular response to the injury. So think of this as though you tore your meniscus and the body created all this TB4 to come to that injury to try to heal that site. That’s exactly what the TB4 is doing inside the body when there’s an injury. It’s been shown in research to help produce new blood vessel formation, promote endothelial cells, It helps modulate inflammatory cytokines, potentially reducing TNF-alpha, IL-1, and possibly protecting in programmed cell death, which we call apoptosis. And some studies suggest that it is cardioprotective in its effects in animal models of myocardial infarction, so heart attack, and neuroprotective in other models for brain injury. Now, these remain to be preliminary, but they are being seen. So the regulatory status on TB4 can create some confusion. Dr. Deb Muth 29:40The natural TB4 molecule itself is not FDA approved as a drug. However, TB4 based drug candidates called RGN259, formerly TB4, has been in the development by regen tree for corneal injuries of the dry eye disease. And as of recent updates, this drug is completed phase three trials for its neurotrophic keratopathy, severe corneal condition. But the FDA approval is still pending. So that means that the most advanced TB4-based pharmaceuticals hasn’t yet crossed the finish line for approval. The commercial peptide market further muddies the picture with TB500, which is often described as the synthetic fragment of TB4. However, this extract’s relationship between TB500 and TB4 varies depending on the source. Dr. Deb Muth 30:41So some claim that TB500 is identical to TB4, but positions 1 through 4 suggest it’s a different fragment. and the quality control across suppliers is not existent. So this confusion is part of why recommending TB500 becomes problematic for practitioners and patients, often because they aren’t certain what molecule they’re actually getting. The evidence base for TB4 in humans is limited, primarily to eye research, and the studies from Sohn’s and colleagues published in journals like Vitamins and Hormones in 2016 have examined topical TB4 for corneal injuries and neurotrophic keratopathy, dry eye, and other surface diseases. Now, these studies showed some promise in promoting this, and there is, however, a topical application to the cornea that is vastly different from a systemic injection. So for systemic use in wound healing, musculoskeletal issues, Dr. Deb Muth 31:42cardiac protection, neuroprotection, human clinical trials. There is scarce to non-existent evidence in humans. Most of the evidence remains in animal models or cell culture studies. And a review by Flip and colleagues in the Journal of Investigational Dermatology in 2006 detailed TB4’s effects on the matrix remodeling during wound repair in animal models, showing effects on collagen disposition, granulation, tissue reformation, and wound contraction. Another review by Ho and colleagues in expert opinion on biological therapy in 2007 discussed TB4’s potential in tissue regeneration and regenerative medicine, but noted the field remained largely blank. preclinical. So this is really important again to understand that there is just not enough human data. So there is a concern with cell division and migration. This theoretically exists Dr. Deb Muth 32:45for the potential effects on cancer cells, which would also rely on migration and division and other intended consequences of disrupting normal cellular architecture. These aren’t proven risks, but they are unexplored questions that we need to be aware of when we’re using peptides. This can cause cancerous tissue to grow. Very similar to what we talked about with BPC-157. These are also sold as research chemicals. There is no FDA oversight. So purity, potency, contaminations all still exist for these peptides. Now from an integrative perspective, the natural presence of TB4 in wound fluid and its biological roles in healing are legitimate science. in presence does not equal therapeutic utility. The body tightly regulates where and when and how much TB4 is present through natural production and bypassing that regulation with external dosing may or may not cause us to have beneficial or introduce risk. Dr. Deb Muth 33:49So we need to know that this is experimental use. Those people who are seeking wound healing and tissue repair the evidence-based approach of the body’s own capacity to heal is huge definitely want to be increasing your protein intake optimizing your zinc copper vitamin c and vitamin a and then managing glucose is really important during this time as well so let’s talk about a fun topic now and that’s growth hormone secretagogues this is the anti-aging hype machine these peptides in this category are things like semoralin ipameralin cjc 1220 1295 and others and among the most aggressively marketed in anti-aging and longevity medicine they all share a common goal stimulating the pituitary gland to release more growth hormone and the appeal is understandable. GH levels decline with age, and this decline is associated with increased fat mass, decreased lean muscle, reduced bone density, and other aspects of aging. Dr. Deb Muth 34:55The other times we’ll see growth hormone levels decline significantly is with chronic illness, and the logic is to restore youthful GH levels and youthful physiology. Now, semirelin from an FDA approved diagnostic to compound anti-aging product. Semirelin is a 29 amino acid peptide representing the first 29 amino acids of the full 44 amino acid human growth releasing hormone, GHRH. We talked about this on another episode of the podcast. And you can go back and listen to that one a little bit if you want. This fragment contains the complete biological activity of the full GHRH molecule and it binds to GHRH receptors in the anterior pituitary and stimulates growth releasing peptides, growth hormone releasing peptides. Semirelin was previously FDA approved as diagnostic testing of growth hormone secretion, essentially, to determine if the pituitary could still respond to GHRH stimulation in patients being evaluated for growth hormone deficiency. Dr. Deb Muth 36:06However, the manufacturer was discontinued and there was no longer an FDA approved semirelin product on the market in the United States. What exists now is semirelin available from compounding pharmacies used off label for anti-aging, body composition, and general growth hormone optimization purposes. This represents a significant gray area. Again, compounding medications serve a very important role, but they need to meet certain recommendations and regulations, as we’ve talked about in the past. You want to make sure that your compounding pharmacy that you’re obtaining semirelin from is qualified to do that, that they are doing best practices, and that you’re getting a good product. The theoretical advantage to semirelin over direct growth hormone administration is that it preserves more of the physiological growth hormone secretion patterns. Natural GH is released in pulses, primarily during sleep, not as a continuous elevation. Dr. Deb Muth 37:07So semirelin stimulates the pulses rather than providing a constant super physiological growth hormone level. And that pulsatile pattern is thought to reduce some of the side effects and metabolic concerns that we have with continuous growth hormone exposure. However, the evidence supporting semirelin for anti-aging and body composition in healthy adults is minimal. Most of the data comes from studies conducted in the 1990s when the FDA approved product existed. Not that that means it’s bad. We have drugs that have been in the market for over a hundred years that are still there, that still have the research and are still being used successfully and safely today. So we don’t want to let that really make us think that this product isn’t safe. So a 2006 review from Walker in Clinical Interventions of Aging suggested that semirelin might be a better approach than direct GH for adult onset growth hormone insufficiency, but they do acknowledge that the evidence was limited. Dr. Deb Muth 38:12And although we don’t have any large scale trials that we can examine for semirelin’s efficacy, it is now commonly prescribed. And the optimal dosing for anti-aging purposes is still unknown. It is considered experimental and it does vary from person to person, but it is still unstudied. The effects on cancer risk, cardiovascular disease, metabolic dysfunction over long time periods are also still unknown. I would argue that the side effects or the risk factors of not having growth hormone are equally as bad as the unknowns that we have here. We’re not looking to try to get super physiological doses. We’re trying to restore youthful GH levels. Typically, we’re not trying to restore back to a 20-year-old. We’re trying to restore back maybe 10 years. That is a better way of doing this. And I think that’s important for people to understand. Now, ipamirelin is the ghrelin mimicker. Dr. Deb Muth 39:12Ipamirelin is a pent-up peptide, five amino acid, that acts as a growth hormone secretagogue receptor, a GHS-R agonist. It mimics the action of ghrelin, the hunger hormone, that also stimulates growth hormone release. The proposed advantage over earlier secretagogues is that ipamirelin stimulates growth hormone release without significantly affecting cortisol, prolactin, or other glucose things, which can be increased by growth hormone secretagogues. The regulatory status is clear. Ipamirelin is not FDA approved for any indication. It’s sold as a research chemical. Human evidence is thin. It’s limited to single dose studies examining how quickly it’s absorbed and metabolized with minimal data on dosing and clinical outcomes. Now there are marketing claims for ipamirelin and they are extensive. Dr. Deb Muth 40:13It increases lean muscle mass, it decreases body fat, it improves sleep quality, faster recovery from workouts, enhanced injury healing, better skin quality. The evidence supporting these claims in humans is not available we don’t have it these are claims that are made by the effects that we know from growth hormone so it’s not necessarily a bad thing we know what growth hormone does we know growth hormone does all of these things if ipamorelin is a precursor to that it will obviously help improve those things making that correlation of what growth hormone does So there are safety concerns that mirror the same as any other growth hormone elevating therapy. It can cause fluid retention, joint pain, carpal tunnel syndrome, insulin resistance, glucose intolerance, and theoretically, can it increase calcium? cancer risks? It can because IGF-1 promotes cell proliferation and can inhibit apoptosis in cancer cells. Now remember, your body makes IGF-1. Dr. Deb Muth 41:15If it’s not making enough of it, that’s a problem. If it’s making too much of it, That’s a problem. So just understand that if you are adding these things, and especially in elevated doses, you are taking a potential risk. So there is also now CJC 1295 is a modified GHRH analog of 30 amino acid peptide based on GHRH structure, but with modifications. So it includes the addition of drug affinity complex, DACC, DAC, which involves conjugation with a small albumin binding molecule, dramatically extends the peptide’s half-life from minutes to as much as potentially a week or more. And this creates sustained growth hormone elevation rather than that pulsatile release. There are actually two versions of this. There’s CJC 1295 with DAC, longer acting version, and CJC 1295 without DAC, which is essentially a shorter duration of semirelin. Dr. Deb Muth 42:19And so when we’re comparing products, it is… only the difference between long acting and short acting. The human evidence for CJC 1295 is limited to a single published phase one study by Techman and colleagues in the Journal of Clinical Nutrition and Metabolism in 2006. And the study involves 18 healthy young adults showed that CJC 1295 with DAC produced a sustained elevation of GH and IGF-1 lasting several days after the injection. That’s essentially the entire published human evidence of this peptide. There are no phase two studies examining optimal dose. So that is all considered experimental. And there is no phase three studies examining clinical efficacy. So the sustained GH levels created by CJC 1295 with DAC raises specific concerns because the natural GH secretion It goes up and down, up and down, up and down. Dr. Deb Muth 43:19And that constant elevation may have a different metabolic and cellular effect. And we just really don’t know what that’s going to be yet. So we can understand that elevated IGF-1 levels can theoretically increase cancer concerns and metabolic risks. So rather than always injecting peptides, which are very expensive… You can do other things. And there was a study by Hartman and colleagues in the Journal of Clinical Endocrinology and Metabolism in 1992 that demonstrated the 48-hour fast increased integrated growth hormone secretion five-fold through increased GH levels. Now, the problem with this is fasting for 48 hours is a challenge. And how long is it going to increase the growth hormone secretion without causing issues? Or in general, how long is it going to go up? Dr. Deb Muth 44:19So we have to be cautious about that as well. Sleep optimization is non-negotiable. The majority of growth hormone secretion occurs during sleep, slow wave sleep, typically the first sleep cycle, and poor sleep quality or insufficient sleep typically. can dramatically affect your growth hormone levels. And then high intensity interval training, HIIT resistance training can stimulate growth hormone as well. This was seen in a study by Godfrey and colleagues in sports medicine in 2003 and was examined in exercise-induced growth hormone responses to athletes. So we definitely see these kinds of things. So let’s talk about some longevity peptides now. These expand the telomere. So there’s epitalin and epithalamin and when these are used in anti-aging they can produce some amazing results. Dr. Deb Muth 45:22So epitalin is a synthetic terapeptide, just four amino acids. It was originally synthesized as a simplified version of epithalamine. a pineal gland extract containing multiple peptides. The synthetic four amino acid version was created to isolate what researchers believed might be the active anti-aging component. The mechanism produced for epitalin centers on telomere and telomerase, Telomeres are protective caps at the end of the chromosomes consisting of repetitive DNA sequencing. And every time a cell divides, telomeres shorten slightly because DNA polymers cannot fully replicate the ends of the linear chromosomes. So this progressive shortening acts as a molecular clock. After 50 or 70 divisions, the telomeres become critically short, triggering a cellular senescence. Dr. Deb Muth 46:22This telomere shortening is one mechanism of cellular aging and telomeres in the enzyme that can rebuild telomeres by adding these caps back onto the end of the chromosome. It’s active in stem cells, germ cells, and unfortunately in about 85 to 90% of the cancer cells. In most adult somatic cells, telomerase is inactive or present at very low levels, allowing the telomeres to shorten with division. The research on epitalin suggests it might activate this telomeres act telomeres process primarily from a research group led by Vladimir in Russia. Vladimir Kavasan in Russia. He is a huge peptide researcher or was he passed away with publications dating back to the early 2000s and a study published in bio gerontology in 2000 by Kavasan Dr. Deb Muth 47:25and colleagues examined the effect of epitalin on the lifespan of fruit flies, and they treated fruit flies that showed a modest increase in mean and maximum lifespan compared to its controls by approximately 10 to 15% lifespan extension in some experimental groups. And there were other studies in 2003 that examined epitalamine in a female Swiss-derived mouse. This was done by Ann Simove and colleagues. And the researchers reported that epitalin treatment was associated with increased lifespan as well. And the most cited mechanistic work comes from cell culture studies. And that is also Cavason’s group that published this research in 2003, showing increased telomeres activity in cultured somatic cells again. More recently, between 20 and 25, the series of publications have continued to explore epithelial effects on telomere dynamics in cell cultures. Dr. Deb Muth 48:32So there is a lot of research that’s been done. The mass majority has been done on epithelin. And most of it has been done by a single research group in Russia. There is some restrictions on some of the cell culture data that we’re seeing. And it does show that epithelin sometimes can be described as a regulating hormone. Carcadian rhythm for melatonin production, which is derived by the penile extracts. And however the evidence for this affects minimally and mechanistically unclear, the pineal gland primarily functions as melatonin secretion in that light-dark cycles. So Epithalin or epitalin is not FDA approved. It is not approved for any major regulatory jurisdiction. It is sold as a research chemical only. Dr. Deb Muth 49:33So you need to follow the same safety profiles that we’ve talked about in other episodes and in today’s episodes. And when we’re talking about epithalin, and we’re excited about it being an anti-aging science, we should balance this with the honesty and the evidence of the quality of that evidence. We don’t know its safety effect. We don’t know if it’s going to increase the risk of cancer. We can’t verify that. And we need to be using it in an experimental use of unknown risks only. Of course, diet, physical activity, stress management, sleep quality, all of those things are important for us to be looking at when we’re looking at these peptides. Now, I want to get into some of the brain peptides. This is the nootrophic frontier. C-Max and C-Lank, there is Russian pharmacology that’s done. C-Max and C-Lank represent an interesting case study in how different regulatory environments and research traditions Dr. Deb Muth 50:36create challenges in evaluating this evidence. Both peptides were developed in Russia, are approved for their specific indications and have substantial Russian language and literature supporting their use. However, the FDA approval in the United States is still not there. C-Max is a seven amino acid. It’s a synthetic analog. It is a fragment, particularly ACTH 4 through 10. It’s sometimes called the melanocortin effects because it involves the melanocortin receptors of the central nervous system. CMAX was developed by the Institute of Molecular Genetics of Russia Academy of Sciences and is approved in Russia for several indications, including acute stroke, transient ischemic attacks, cognitive disorders. It has Russian approval and is based on clinical trials primarily in Russia. Dr. Deb Muth 51:39It does help to increase brain-derived neurotrophic factor, BDNF, a protein critical for neuroplasticity, the brain’s ability to form new connections and adapt to the challenges. BDNF supports neuronal survival and promotes growth of these new neurons. C-Max also influences neurotransmitter systems, particularly dopamine and serotonin, and there is some research that suggests it affects on metabolism as well, and endogenous opioid peptides that involve pain reception and mood regulation. So it has some good potentials there. There is also C-Link, which is a hepatopeptide structurally similar to Tufts’ and an immune modulatory peptide. It was also developed in Russia and was approved for anxiety disorders as a neurotropic. Its effects involve anxiolytic effects, possibly through the GABAnergic system or the GABA system of the brain, and immune modulation. Dr. Deb Muth 52:44The Russian research is examined by C-Link for anxiety disorders. and finding reductions in anxiety without sedation. There is a dependency potential or cognitive impairment does not exist like it does with benzodiazepines with C-Link. So that is really good. And they do report attention and memory improvement using C-Link. There is a study that was done in neuroscience and behavioral psychology in 2018 that examined C-Linx effects and proposed that it exerts cytoprotective effects through BDNF pathways similar to C-Max. So both of these are Russian research-based They’re not wrong or fraudulent. It’s just that they are from Russia and we all have our concerns with Russia. However, that does not necessarily mean their research doesn’t hold quality. Dr. Deb Muth 53:49Neither peptide is approved by the FDA, and so you are using this off-label. The same rules apply for all of the other peptides that we’ve talked about that are produced off label. You want to do the same things that you would do with anything else. Good protein, omegas, B vitamins, acetylcarnitine, exercise, sleep, all of that still applies when we’re using these peptides. So I want to talk briefly about clinical decision and framework when we’re looking at this. First and foremost, we always want to go to FDA-approved peptides. Secondly, we would look at international approval with peptides that are established in other countries but lack FDA approval. And then preclinical evidence only or experimental peptides. These can be used, but they are not ethically recommended in the traditional medicine world. Dr. Deb Muth 54:50 If patients use them, we need to have appropriate counseling about the evidence surrounding them, the safety, and where to find them. how to find them and how to ask for these certificates of analysis. So I think it’s really good that we were exploring all these peptides and understanding what they are. There’s a lot of controversy out there. There’s a lot of concern out there. And what we can say with confidence is that peptides are powerful biological signaling molecules. Some peptide based medications, semi-glutide, triseptide, PT 141, Lupron that are all FDA approved. can dramatically improve outcomes in patients that are obviously selected for the correct ones. There are many other peptides that we address that are integrative and longevity space in the regenerative medicine. These peptides are all experimental. That does not automatically make them wrong. Dr. Deb Muth 55:50It just means that we need to be honest about what we’re doing with them and we need to be cautious with the patients so that they can make a decision to be part of an experimental study. in looking at how to use these peptides. So peptides are tools like any other tools. They work best in the hands of skilled people, and they are applied to appropriate situations, integrating into comprehensive approaches that address root causes. The most powerful peptide administered to a patient with untreated inflammation, hormonal chaos, nutritional deficiencies, and disorders of sleep will disappoint. The simplest evidence-based interventions apply. to a patient whose foundational physiology has been optimized. And this is the art of the science of peptide, right? If done right, respecting both the power of these molecules and the complexity of human beings that we are privileged to serve can make a difference in their lives. So thank you for listening to this episode. Dr. Deb Muth 56:52I hope this was helpful. If you can know of somebody that might benefit from this, please like, share, and subscribe. It means a lot to us. And I hope you join us for our next episode of Let’s Talk Wellness Now. Welcome to Let’s Talk Wellness Now, where we bring expert insights directly to you. 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We may update this disclaimer at any time and changes will take effect immediately upon posting or broadcast. Thank you for tuning in. We hope you find this episode both insightful and thought-provoking. Listener discretion is advised.The post Episode 258 – Investigational Peptides: What's Promising, What's Hype & What You Must Know first appeared on Let's Talk Wellness Now.

Why does cancer fatigue linger long after treatment ends and what can you actually do about it? In this episode of Integrative Cancer Solutions, Dr. K sits down with integrative oncology expert Dr. Jessa Landmann to unpack the real causes of cancer related fatigue. From inflammation and muscle loss to sleep disruption, hormone changes, and iron deficiency, this conversation reveals why fatigue is not just “in your head” and does not have to be your new normal. Dr. Landmann shares cutting edge research on muscle degradation during and after treatment, the role of insulin and blood sugar in cancer progression, the power of acupuncture, adaptogens, and mind body medicine, and why early lifestyle intervention is critical. If you or someone you love is navigating cancer recovery and struggling with low energy, brain fog, or weakness, this episode provides a practical and empowering roadmap forward. Key Takeaways: 0:00 Introduction 2:40 Why naturopathic medicine is powerful during cancer care 6:15 Can natural therapies enhance chemotherapy and radiation 8:30 Mind body medicine, trauma, and emerging psychedelic research 12:00 Cancer nutrition myths keto, sugar, and the glycemic index 16:00 Does sugar feed cancer Understanding insulin and IGF 1 19:10 Cancer fatigue explained inflammation, muscle loss, hormones Resources Mentioned: Listener Discount Get 20% off Beyond Cancer Fatigue: A Path to Reclaiming Energy when you order directly from the Wiley website using code TIRED at checkout. Offer expires May 28. Medical Disclaimer: This content is for educational purposes only and is not intended to diagnose, treat, cure, or replace professional medical advice. Always consult your physician or qualified healthcare provider regarding any medical condition or treatment decisions. -----------------------------------------------A Better Way to Treat Cancer: A Comprehensive Guide to Understanding, Preventing and Most Effectively Treating Our Biggest Health ThreatGrab my book here: https://www.amazon.com/dp/B0CM1KKD9X?ref_=pe_3052080_397514860 Unleashing 10X Power: A Revolutionary Approach to Conquering CancerGet it here: https://store.thekarlfeldtcenter.com/products/unleashing-10x-powerPrice: $24.99100% Off Discount Code: CANCERPODCAST1Healing Within: Unraveling the Emotional Roots of CancerGet it here: https://store.thekarlfeldtcenter.com/products/healing-withinPrice: $24.99100% Off Discount Code: CANCERPODCAST2-----------------------------------------------Integrative Cancer Solutions was created to instill hope and empowerment. Other people have been where you are right now and have already done the research for you. Listen to their stories and journeys and apply what they learned to achieve similar outcomes as they have, cancer remission and an even more fullness of life than before the diagnosis. Guests will discuss what therapies, supplements, and practitioners they relied on to beat cancer. Once diagnosed, time is of the essence. This podcast will dramatically reduce your learning curve as you search for your own solution to cancer. To learn more about the cutting-edge integrative cancer therapies Dr. Karlfeldt offer at his center, please visit www.TheKarlfeldtCenter.com

Most people fear cancer, but they're never given a clear explanation of what it actually is, how it progresses, or why metastasis, not the initial tumor, is what kills 90% of people with solid tumors. And here's what almost no one talks about…30 minutes of exercise per day can down-regulate 13 types of cancers. I break down the biology of cancer and metastasis in plain language, then walk you through the evidence linking exercise to cancer outcomes across prevention, treatment, and survivorship. I explain how cancer cells have to physically enter circulation and survive a hostile journey to metastasize, and here's the part that changed how I think about high-intensity exercise: as shear stress increases during vigorous exercise (zone 5, 90%+ max heart rate), survival of circulating tumor cells decreases. I also cover immune surveillance, metabolic signaling, and why this is deeply personal for me. Reduce your risk of Alzheimer's with my science-backed protocol for women 30+: https://go.neuroathletics.com.au/youtube-sales-page Subscribe to The Neuro Experience for evidence-based conversations at the intersection of brain science, longevity, and performance. Topics Discussed 00:00 Intro: Why Cancer Is What Scares Me Most 01:37 Why We're Having This Conversation 03:33 What This Episode Covers: The Three-Part Framework 06:21 What Cancer Actually Is: When Cells Break the Rules 07:25 Metastasis: The Part of the Story No One Explains 27:57 Shear Stress and Circulating Tumor Cells: The Zone 5 Effect 30:16 Immune Surveillance: How Exercise Mobilizes Killer Cells 30:51 Metabolic Signaling: Insulin, IGF-1, and Inflammation 32:16 Limitations: What the Evidence Can and Can't Tell Us 34:37 Practical Framework: Prevention, Treatment, and Survivorship 36:04 Closing: Exercise as Repeated Physiological Stress Thank you to our sponsors Ketone-IQ: https://ketone.com/NEURO IQ BARS: Text NEURO to 64000 to get 20% off all IQBAR products Cure Hydration: http://curehydration.com/NEURO Cellure: https://cellure.co/ and use code NEURO Arrey: https://arey.com/ and use code NEURO _______ I'm Louisa Nicola - clinical neurophysiologist - Alzheimer's prevention specialist - founder of Neuro Athletics. My mission is to translate cutting-edge neuroscience into actionable strategies for cognitive longevity, peak performance, and brain disease prevention. If you're committed to optimizing your brain- reducing Alzheimer's risk - and staying mentally sharp for life, you're in the right place. Stay sharp. Stay informed. Join thousands who subscribe to the Neuro Athletics Newsletter → https://bit.ly/3ewI5P0 Instagram: https://www.instagram.com/louisanicola_/ Twitter : https://twitter.com/louisanicola_ Learn more about your ad choices. Visit megaphone.fm/adchoices

STOP intermittent fasting if you think it automatically keeps you young. In this episode, you'll learn why short-term fasting results can mislead long-term aging outcomes, and how duration, frequency, refeeding, and protein intake determine whether fasting supports longevity or quietly accelerates decline. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Valter Longo, one of the world's leading longevity researchers with over 30 years of experience studying aging, nutrition, and disease prevention. Dr. Longo is the Director of the Longevity Institute at the University of Southern California's Leonard Davis School of Gerontology and the Director of the Longevity and Cancer Program at IFOM, the Italian Foundation for Cancer Research Institute of Molecular Oncology in Milan. He is the author of the bestselling book The Longevity Diet and was named one of TIME Magazine's 50 most influential people in health care for his research on fasting-mimicking diets. Together, Dave Asprey and Dr. Longo explain why many people focus too heavily on short-term effects and extrapolate them incorrectly across a lifetime. They break down how intermittent fasting differs biologically from multi-day fasting, why five-day fasting cycles trigger deeper cellular changes, and how insulin, IGF-1, mTOR, and growth hormone shape aging, regeneration, and disease risk over time. The conversation covers protein and amino acid intake, muscle preservation, frailty risk, and the tradeoffs between strength, function, and longevity. They explore ketosis, fasting-mimicking diets, stem cell activation, mitochondrial function, neuroplasticity, and why equilibrium and cycling matter more than constant restriction. Dave and Valter also discuss supplements, nootropics, creatine, carnivore-style eating, metabolism, sleep optimization, and how AI may eventually personalize fasting and nutrition based on individual biology rather than population averages. You'll learn: • Why short-term fasting benefits do not predict long-term longevity • How fasting duration changes gene expression and cellular regeneration • The difference between intermittent fasting and multi-day fasting • How protein and amino acids influence mTOR, IGF-1, and aging • Why muscle, strength, and longevity must be balanced, not maximized • When ketosis overlaps with fasting and when it does not • Why supplements can disrupt biological equilibrium • How AI could support future personalization in fasting and nutrition Dave Asprey is a four time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Thank you to our sponsors! • BEYOND Conference 2026 | Register now with code DAVE300 for $300 off at https://beyondconference.com/• AquaTru | Go to https://aquatruwater.com/daveasprey and save $100 on all AquaTru water purifiers.• Caldera + Lab | A small habit with big results. Go to https://CalderaLab.com/DAVE and use code DAVE for 20% off your first order.• Timeline | Go to https://timeline.com/Dave for 20% off.Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: intermittent fasting longevity, fasting mimicking diet, fasting and aging science, biohacking fasting podcast, longevity fasting research, protein restriction longevity, amino acids aging, mTOR IGF-1 longevity, mitochondria aging science, neuroplasticity fasting, ketosis fasting science, metabolism longevity podcast, anti-aging fasting, functional medicine longevity, supplements fasting debate, nootropics brain optimization, muscle frailty aging, sleep optimization longevity, AI personalized nutrition, carnivore diet longevity debate, Dave Asprey fasting, Valter Longo longevity, longevity diet podcast, human performance aging Resources: • Learn More About Valter's Work At: https://valterlongo.com/ • Join My Fasting Challenge: https://daveasprey.com/#14-day • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Join My Low-Oxalate 30-Day Challenge: https://daveasprey.com/2026-low-ox-reset/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com Timestamps: 0:00 Introduction & Aging Fundamentals 4:36 Fasting Mimicking Diet Overview 7:03 Insulin, IGF-1 & mTOR 11:03 Body Fat & Fasting Frequency 17:08 The Protein Debate 20:22 Blue Zones & Centenarian Evidence 23:10 Amino Acids & Leucine 30:30 Growth Hormone & Longevity 34:01 Five-Day Fasting Benefits 40:55 Personalization & AI 42:29 Plant-Based Concerns 49:07 Fasting Risks & Limits 53:05 Supplements & Equilibrium 1:03:05 Ranking Longevity Pathways 1:05:05 Modern Environmental Challenges 1:16:21 Final Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.