Podcasts about igf

In this episode of the Day 0 Update: We talk about Titanium Court winning the Grand Prize at the IGF awards, WarioWare's director leaving Nintendo, and the bad news about Mega Man: Dual Override. All this and more, up next!Full show notes can be found ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠here⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠.

Why does cancer fatigue linger long after treatment ends and what can you actually do about it? In this episode of Integrative Cancer Solutions, Dr. K sits down with integrative oncology expert Dr. Jessa Landmann to unpack the real causes of cancer related fatigue. From inflammation and muscle loss to sleep disruption, hormone changes, and iron deficiency, this conversation reveals why fatigue is not just “in your head” and does not have to be your new normal. Dr. Landmann shares cutting edge research on muscle degradation during and after treatment, the role of insulin and blood sugar in cancer progression, the power of acupuncture, adaptogens, and mind body medicine, and why early lifestyle intervention is critical. If you or someone you love is navigating cancer recovery and struggling with low energy, brain fog, or weakness, this episode provides a practical and empowering roadmap forward. Key Takeaways: 0:00 Introduction 2:40 Why naturopathic medicine is powerful during cancer care 6:15 Can natural therapies enhance chemotherapy and radiation 8:30 Mind body medicine, trauma, and emerging psychedelic research 12:00 Cancer nutrition myths keto, sugar, and the glycemic index 16:00 Does sugar feed cancer Understanding insulin and IGF 1 19:10 Cancer fatigue explained inflammation, muscle loss, hormones Resources Mentioned: Listener Discount Get 20% off Beyond Cancer Fatigue: A Path to Reclaiming Energy when you order directly from the Wiley website using code TIRED at checkout. Offer expires May 28. Medical Disclaimer: This content is for educational purposes only and is not intended to diagnose, treat, cure, or replace professional medical advice. Always consult your physician or qualified healthcare provider regarding any medical condition or treatment decisions. -----------------------------------------------A Better Way to Treat Cancer: A Comprehensive Guide to Understanding, Preventing and Most Effectively Treating Our Biggest Health ThreatGrab my book here: https://www.amazon.com/dp/B0CM1KKD9X?ref_=pe_3052080_397514860 Unleashing 10X Power: A Revolutionary Approach to Conquering CancerGet it here: https://store.thekarlfeldtcenter.com/products/unleashing-10x-powerPrice: $24.99100% Off Discount Code: CANCERPODCAST1Healing Within: Unraveling the Emotional Roots of CancerGet it here: https://store.thekarlfeldtcenter.com/products/healing-withinPrice: $24.99100% Off Discount Code: CANCERPODCAST2-----------------------------------------------Integrative Cancer Solutions was created to instill hope and empowerment. Other people have been where you are right now and have already done the research for you. Listen to their stories and journeys and apply what they learned to achieve similar outcomes as they have, cancer remission and an even more fullness of life than before the diagnosis. Guests will discuss what therapies, supplements, and practitioners they relied on to beat cancer. Once diagnosed, time is of the essence. This podcast will dramatically reduce your learning curve as you search for your own solution to cancer. To learn more about the cutting-edge integrative cancer therapies Dr. Karlfeldt offer at his center, please visit www.TheKarlfeldtCenter.com

Dr. Deb Muth 0:00 Welcome back to Let’s Talk Wellness Now. I’m your host, Dr. Zab, and we are continuing our discussion this week on 0:08 peptides. And so, if you haven’t heard our first conversation about peptides, 0:13 please go back and look at that episode. We talk all about the manufacturing, the safety, the quality of peptides, and we 0:20 dove into GLP1s. And today we’re going to dive into peptides for sexual 0:26 wellness, immune function, growth hormone, and all the amazing fun things 0:32 we can do with peptides. So, as usual, grab your cup of coffee or tea, settle 0:37 in, and let’s talk wellness now. And we’re going to take a short pause from our sponsor. I know we’ve got to do 0:44 that, you guys. They’re who keep us on the air. So, I’m going to pause for just a minute and be right back after this 0:50 message from our sponsor. Ladies, it’s time to reignite your vitality. Primal 0:56 Queen supplements are clean, powerful formulas made for women like you who want balance, strength, and energy that 1:03 lasts. Get 25% off at primal queen.com. Serenity Health. That’s primalqueen.com. 1:10 Serenity Health. Because every queen deserves to feel in her prime. All 1:15 right, everybody. We are back. And are you ready? We are talking all things peptide and I am opening the show today 1:23 with sexual wellness. Yes, I’m going there, you guys. I am going there. You 1:29 know, this has really become a big issue for people um of all ages. It’s not just 1:3 4us older people. It’s younger people, too. And there’s a whole variety of reasons why we have sexual dysfunction. 1:42 And when we’re talking about sexual dysfunction, we’re not just talking about it doesn’t work, right? Or I can’t 1:48 reach orgasm. A lot of it is around desire and um the thought of it and 1:54 wanting to connect, wanting to be kinder to one another, wanting to be touching 2:00 one another. A lot of it resolves or revolves around that. And so there are some peptides that can help us and I’m 2:08 really excited to be able to talk about those today. So the first one is called PT-141. 2:14 This targets the brain not the periphery. Right? So for many women I 2:20 will always tell you sex starts between here. It is a brain thing for us. It is 2:26 not necessarily a physical thing. For guys that’s a little different. It’s very physical. For women it’s all in our 2:32 brain. So tip for you men that are listening. You have to prime your woman’s brain first if you want her to 2:38 have sex with you that night. You have to be nice to her. You have to bring her flowers. Do the dishes for her. Do 2:45 something kind. Bring her a cup of coffee or tea or a glass of wine. Take her to dinner. You have to woo her. And 2:51 I don’t care how long you’ve been married. That has to happen. And tip number two, don’t say anything stupid 2:57 that day. I’m just being honest. When you guys say things that make us upset, 3:03 that lingers with us for the rest of the day. And it’s it’s a turnoff for us. And 3:08 for a lot of women, we can’t get past that when it comes time to snuggle at night. And sex doesn’t always have to be 3:14 at night either. So, you can tell I really love talking about this conversation, but we’re going to get into the peptide part of it because this 3:21 is going to help people. So, um, PT-141 is marketed as I’m going to slaughter 3:28 this name, Vali, and it represents a fundamentally different approach to 3:34 sexual dysfunction than the PDE5s inhibitors like Slenden, Viagra, 3:40 Tedataphil, which is Seialis. And while the PDE5 inhibitors work specifically by 3:47 enhancing blood flow to the genital tissues, PT-141 works centrally in the brain by 3:54 modulating neural s neural circuits involved in the sexual desire and 4:00 arousal. Now PT-41 is a cyclic hpatipeptide. It’s seven amino acid 4:07 peptide arranged in a cyclic structure that acts as a melanoortin receptor 4:13 agonist and with particularly the infinity for MC3R and MC4R subtypes. 4:20 It’s actually a metabolite of the melanotan 2, a peptide originally 4:26 developed for tanning that was also found to enhance sexual desire in early 4:31 studies. Now the melanoortin system in the brain is involved in multiple functions including energy homeostasis 4:39 but it also is involved in sexual motivation and arousal behaviors. The FDA approved PT-141 in 2019 specifically 4:48 for the treatment of acquired generalized hypoactive sexual desire 4:54 HSDD in permenopausal women. So for the first time we have a medication that was 5:01 approved by the FDA to use for women for sexual dysfunction. We have had all of 5:07 these seialis tedataphil viagros for men but we had nothing for women. And so 5:12 this is amazing that this is available for women and approved by the FDA. It’s a big deal. This represents the first 5:19 and only FDA approved medication specifically targeting these circuits of sexual desire rather than the peripheral 5:27 arousal mechanisms. And this indication is quite specific, meaning it was developed at some point, not lifelong. 5:35 So I if you’ve had sexual dysfunction your entire life, this medication was 5:40 not approved for you. But if it’s something that you developed over time, like when you went through pmenopause or 5:46 menopause or some women have this experience happen after childirth, that’s what we’re talking about here. 5:53 Now, it’s also not just um supposed to be used if you dislike your partner, 5:59 right? If your relationship is bad and you dislike your partner, this probably isn’t going to fix a ton. It might help 6:05 a little bit, but that’s not what it’s meant for. So, you really have to know what you’re using it for and why. And 6:11 the other thing that I would say is this is something that we don’t go to if your hormones are not balanced properly. You 6:17 have to balance your hormones properly before using something like this because it still may not work. Now, the only 6:24 caveat to that is if you’re a woman that has a risk of breast cancer and can’t use hormones, then that’s a different 6:31 story and we would have that conversation about whether or not this medication would be appropriate for you. Now, the FDA label specifies PTA1 uh 6:39 PT-141 as it not being indicated for HSDD in causes where low sexual desire 6:46 is due to coexisting medical or psychiatric conditions, problems with relationships, like we had talked about, 6:53 side effects to medications or other substance use. This specifically reflects the importance of differential 6:59 diagnosis. Low sexual desire can have many root causes and PT-41 is only 7:05 appropriate when those causes have been ruled out. Now, I have I used PT41 in 7:10 people who have sexual dysfunction issues as a result of using 7:16 anti-depressants. Yes, I have. I’ve used Flynn in that effect as well. And it 7:21 does work sometimes, but it doesn’t work completely. But you need to know that that is not what the approval is for the 7:27 FDA. So that is done in something that we call off label use. So very important 7:33 to know. Now in these clinical trials leading to FDA approval, this was published by Kinsburg and colleagues in 7:40 obstetrics and gyne gynecology in 2019. PT-141 demonstrated statistically 7:46 significant improvements in sexual desire and decreases in distress related 7:51 to low desire compared to placebo. The effects manifest over 45 minutes to 7:56 several hours after the injection and the mechanisms involved modulation of dopamine and melanoorton pathways in the 8:04 hypothalamus and the brain regions that involved sexual motivation. Now cardiovascular effects of PT 141 require 8:12 careful attention. This drug causes transient increases in blood pressure about 3 to four points and transient 8:20 decreases in heart rate. And because of this, it is contraindicated in patients 8:25 with uncontrolled hypertension or known cardiovascular disease. And it has been studied in patients who’ve had recent 8:32 cardiovascular events or sorry hasn’t been studied hasn’t been studied in patients who’ve had recent 8:39 cardiovascular events. So patients need to have their blood pressures checked before starting therapy. Nausea is 8:45 extremely common. It is one of the biggest things I often will tell people to take an anti-nausea medicine if 8:52 they’re going to do this because the last thing you want to do is inject this medication and think it’s going to give 8:57 you this great time with your partner and you’re so nauseated that you can’t even perform, don’t want to kiss, don’t 9:05 want to do anything. It it can be pretty profound for some people. um it does affect about 40% of the patients in 9:12 clinical trials which is why many clinicians require or recommend an 9:17 anti-nausea medication like I had just said other common adverse effects include flushing injection site 9:24 reactions headache in about 13% of the population which I have seen worse if 9:30 people are prone to headaches and the headaches are pretty intense so I will also have them premedicate if they have 9:36 that um sensitivity ity with a Tylenol or Advil, Alie, whatever it is they 9:42 typically use for their headaches to help prevent that from occurring. Now, some patients also experience a 9:50 generalized hyperpigmentation of their skin, particularly in areas with chronic friction, and this may not be reversible 9:57 after discontinuation. So from an integrative perspective, PT-41 10:03 represents one tool in addressing female sexual dysfunction, but it should never be the first or only intervention. And 10:11 low sexual desire in women is complex. Multiffactorial involving hormonal imbalances, low testosterone, estrogen 10:18 deficiency, progesterone imbalances, thyroid dysfunction, adrenal dysfunction, and with elevated or 10:24 disregulated cortisol levels, sleep deprivation, relationship issues, unresolved trauma, including sexual 10:31 trauma, chronic pain, body image concerns, and medication side effects such as SSRIs are notorious for this. So 10:39 a comprehensive hormone panel including total and free testosterones, estradile, 10:45 progesterone, DHEA, thyroid function in cortisol assessment, ideally four-point 10:51 cortisol, salivary should precede any pharmacological intervention. And additionally, addressing the 10:57 psychological component and relationship dimensions through appropriate therapy is necessary. I have a lot of patients 11:03 that say, “This is just too much work for sex. I don’t want the side effects. I don’t want to deal with this.” and that’s totally fine. But for some 11:09 people, their sexual dysfunction is actually causing more problems on their 11:14 relationship and they want to do something to fix that. And just know that if you’re using a peptide like this 11:20 that comes with some of these side effects and you have to premedicate for it, it is not the end of the world. Um, 11:27 but it may be a possibility that you may need that. So, let’s dive into body composition and growth hormone access. 11:34 So Tesmarellin is the only FDA approved GH 11:40 analog. Tesarelin is marketed as Agrifta and Agria SV. It is a synthetic analog 11:48 of human growth hormone releasing hormone. So GH RH human growth hormone 11:53 releasing hormone. These things are such long names it’s confusing and it’s difficult to spit out, right? It 11:59 consists of 44 amino acids. The structure is identical to our own 12:05 body’s growth hormone GHR um with the addition of trans3 hexonol group which 12:14 stabilizes the molecule that extends its half-life compared to the native GHR. 12:19 The mechanism of tesmarellin is elegant in its preservation of physiological 12:24 growth hormone GH secretion patterns and rather than administering an exogenous 12:30 growth hormone directly, tesmarillin binds to the GH receptor in the anterior 12:36 pituitary gland stimulating the indogenous pulsatile release of GH. So 12:42 you know it it’s slower in that stimulation and it pulsates instead of a direct rise and fall. This pusile 12:49 pattern more closely mimics natural GH secretion which occurs in bursts 12:54 primarily during sleep. The GH then stimulates the liver to produce insulin-like growth factor IGF-1 which 13:01 exerts many of the downstream metabolic effects including lipolytic effects on 13:07 the atapost tissue. So fat atapose and how we break that down. The FDA approved 13:13 tesmarellin in 2010 for a very specific narrow indication, the reduction of 13:19 excess abdominal fat in HIV infected patients with lipodistrophe. This 13:25 condition characterized by abnormal fat redistribution with accumulation of visceral body fat and the loss of 13:32 subcutaneous fat in face and limbs developed as a complication of an 13:37 antiviral therapy particularly with older protease inhibitor reg uh 13:42 regimens. The visceral fat accumulation in patients is not just cosmetic. It’s associated with increased cardiovascular 13:49 risk, insulin resistance, and inflammatory markers. The pivotal trial that led to the FDA approval included 13:56 work by Stanley and colleagues published in the annuals of internal medicine in 2014. It demonstrated that tesmarillan 14:03 significantly reduced the visceral atapose measured by CT scan by approximately 15 to 20% which is a 14:10 significant difference to placebo over a short period of time only 26 weeks. Now, 14:16 interestingly, the total body uh weight typically remained stable or even 14:21 increased slightly as the reduction of visceral fat was sometimes offset by increases in lean body mass or 14:28 subcutaneous fat. This highlights an important point. Tesmearellin is not a weight loss drug in its conventional 14:34 sense. Its effects are specifically on body composition and fat redistribution. 14:40 Now the glucose metabolism effects of tesmarellin do require careful monitoring because GH and IGF1 can 14:47 induce insulin resistance. Tesmearellin can increase glucose levels and hemoglobin A1C and in these clinical 14:54 trials glucose tolerance and new onset diabetes occurred in some patients. So 14:59 this creates a therapeutic paradox while res reducing visceral fat we should theoretically improve metabolic health. 15:07 The GH mediated insulin resistance can worsen the glycemic control and patients 15:12 with diabetes require particularly close monitoring. The potential need for adjustment in diabetic medications can 15:19 occur. So I already know what you guys are thinking. Can I use Tesmarellin and 15:24 GLP1 at the same time? And the answer is yes. Especially in those people that we 15:30 know have an insulin resistance already or are prone to that, we can use lowd 15:36 dose micro doing GLP-1 along with tesmarellin to help prevent this from 15:42 occurring um or reduce the risk of it occurring. Now there are some other adverse related problems to growth 15:49 hormone access which include fluid retention which can uh manifest as uh 15:55 ankle swelling, joint pain, muscle pain, paristhesas, carpal tunnel syndrome is 16:01 common to see. Of course you can always see injection site reactions reported about 26 to 30% of the time in the trial 16:08 participants. And this also theoretically has a concern about IGF-1 elevation potentially promoting 16:14 malignancy through long-term data is limited. So we have to be cautious about 16:20 this but it is a growth hormone and anything that is a growth hormone can cause cells to grow and it cannot 16:26 necessarily differentiate between healthy cells and bad cells. So the drug is contraindicated is contraindicated in 16:33 patients with active cancer and in patients with the disruption of the HPA access from conditions like pituitary 16:40 tumors, pituitary surgery, head of radiation um and traumatic brain injury. 16:46 Now off label use of tesmarellin for general anti-aging or body composition 16:51 optimization in non-HIV population, it doesn’t have FDA approval. There is no 16:58 FDA studies. um that promote this, but practitioners do prescribe it for these 17:04 purposes under an experimental and not supported by FDA approved indications. 17:10 And um from an integrative medical standpoint, optimizing natural growth 17:15 hormone secretion through lifestyle interventions, high quality sleep is important. GH primarily is excreted 17:22 during sleep and deep sleep waves. So improving your deep sleep is important. Intermittent fasting can also increase 17:28 growth hormone by five-fold as demonstrated in a Hartman and colleagues uh study from the journal of clinical 17:35 endocrinology and metabolism in 1992. And highintensity interval training, adequate dietary protein, blood sugar 17:42 control, these all can help naturally increase your growth hormone. So, let’s 17:47 dive in now and talk about bone health. peptide hormones um such as oh I’m gonna 17:54 I’m gonna really slaughter this name. Terraparatide is a true bonebuilding 18:01 peptide. It’s marketed as forio. It’s a recumbent form of the first 34 amino 18:08 acids out of 85 of the human parathyroid hormone PTH. It represents a unique 18:13 approach to osteoporosis treatment because it’s one of the few truly anabolic anabolic bone therapies meaning 18:21 it actively binds new bone rather than simply preventing bone loss. The biology 18:26 of parathyroid is fascinating and seemly contraindicated or uh contradictory. 18:32 Continuously sustained elevations of PTH as occurs in hyperarathyroidism 18:37 is catabolic to bone. So people who have hyperarothyroidism typically have significant bone loss 18:44 especially before it’s diagnosed and it causes causes increased bone 18:49 reabsorption loss of bone density increased fracture risk and however 18:55 intermittent exposure to PTH as achieved with once daily uh injections of forio 19:01 has the opposite effect. This intermittent exposure preferentially stimulates osteoblasts bone building 19:08 cells over osteoclasts bone reabsorbing cells and it leads to 19:13 the net bone formation. So terraparatide binds to the PTH receptors on 19:20 osteoblasts and renal tubular cells in bone. It increases the number of 19:25 activity of osteoblasts stimulating the differentiation of osteoblast precursor cells and may 19:32 reduce osteoblast apoptosis basically programmed cell death allowing this bone 19:37 building cell to work longer. The result is increased bone formation, improved bone architecture and tbacular 19:45 connectivity and ultimately increased bone mineral density um particularly in the hip and the spine which is so 19:51 difficult to regain. The FDA approved this medication in 2002 based on pivotal 19:57 studies by Near and colleagues published in the New England Journal of Medicine in 2001 which demonstrated significant 20:05 reductions in vertebral and non-vebral fractures in post-menopausal women with 20:11 osteoporosis. specifically uh reduced new vertebral fractures by 20:17 65% and nonvettebral fragility fractures by 53% 20:23 compared to placebo over a median followup of 21 months. This is really 20:29 incredible because we have not seen this kind of um change uh in other 20:35 medications that we’ve used for osteoporosis. So current FDA approval 20:40 indicates uh this for post-menopausal women with osteoporosis at high risk for 20:46 fracture, men with primary or hypoconatal osteoporosis at high risk for fracture 20:53 and men and women with glucocord cord glucocordide 21:00 induced osteoporosis at high risk for fracture. The high risk qualifier is 21:05 important. uh terrapeptide is reserved for patients with severe osteoporosis, 21:11 multiple fractures, very low low bone density and those who have failed or are 21:16 intolerant of other therapies. The most significant concern for this medication 21:21 is highlighted in a boxed warning with rat toxicology studies where it caused 21:27 osteioaroma which is a bone cancer in a dose dependent and treatment duration dependent manner. The revolence of this 21:34 finding to humans is debated. Rats have fundamentally different bone biology than humans with continuous bone growth 21:41 throughout life and different PTH receptors. Now post marketing 21:46 surveillance in humans hasn’t shown a clear increase in osteocaroma risk but 21:51 theoretically concerns persist and because of this terapeptide is 21:57 contraindicated in patients at risk baseline risk for osteioaroma 22:02 including those with pageantss disease of the bone unexplained elevations of alkaline phosphate prior skeletal 22:10 radiations bone metastases or skeletal malignancies and pediatric patients or young adults 22:16 with open hyes. There’s also a lifetime treatment duration of only 2 years and 22:22 terrapeptide can cause transient hypercalcemia. So an elevated blood calcium and as PTH normally increases 22:31 calcium levels by enhancing bone reabsorption, increasing renal calcium 22:36 reabsorption and promoting activation of vitamin D which increases intestinal calcium absorption. Some patients 22:43 experience orthostatic hypotension within 4 hours of injecting requiring 22:48 caution in at risk populations for blood pressure. Common side effects include 22:53 muscle pain, joint pain, pain in the limbs, nausea, headache, and dizziness. So from an integrative bone health 23:00 perspective, terrapeptides should be part of a comprehensive strategy. Adequate calcium intake, 500 to a,000 23:08 milligrams of calcium a day from food and supplements combined. and vitamin D. 23:13 Getting vitamin D levels of at least 50 to 80 are essential for the drug to work 23:20 optimally. But beyond this, bone health requires vitamin K2, which directs calcium into the bones rather than soft 23:27 tissues, magnesium as a co-actor in bone metabolism, trace minerals like boron, 23:33 copper, silica, and of course, adequate protein intake, which many of us, especially as women, don’t do 0.8 8 to 1 23:42 gram of protein per kilogram of body weight, weightbearing exercise. Of 23:47 course, these all provide mechanical signals that complement the biochemical 23:52 symbol uh signals of terrapeptide. Sequential therapy is also critical. The 23:58 bone mass gains from terraparatide can be lost if patients don’t transition to 24:05 an anti-resorbbitive agent a bisphosphinate after completing this therapy and the anabolic effects to 24:12 build bone but maintaining the new bone requires preventing excess reabsorption. 24:18 So positive things about this but there are definitely some concerns as well. So 24:23 the next one we’re going to talk about is Lu Prolrooide. It is marketed under 24:29 the multiple brand names of Lupron, Depo, Eligard, and it’s a synthetic 24:34 nonapeptide analog of naturally occurring ginonadotropen releasing 24:39 hormone G&R, also called luteinizing hormone releasing hormone, LHR. 24:46 It’s a fascinating example of how manipulating natural hormonal feedback systems can create therapeutic effects. 24:53 So, G&RH is normally secreted in a pulsatile fashion by the hypothalamus 24:59 and travels to the anterior pituitary where it binds to G&R receptors and 25:05 stimulates the release of luteinizing hormone LH and follical stimulating hormone FSH. These ginatotropins signal 25:13 the ovaries or the testes to produce sex hormones, estrogen, progesterone in 25:18 women, testosterone in men. Uh, luoprololi lupron as a GNR agonist 25:26 initially mimics the action of natural G&R causing an acute flare response with 25:33 uh increased LHFSH secretion which temporarily increases sex hormone 25:38 production. However, the continuous administration which is in the depo 25:44 formulations, the GNR receptors in the pituitary become desensitized and 25:50 downregulated. And after about 2 to four weeks of continuous exposure, LH and FSH 25:56 secretion is profoundly suppressed, leading to what’s termed as chemical 26:01 castration. Testosterone levels in men drop to castrated levels less than 50 26:08 and estrogen production is marketkedly suppressed in women. This bifphasic 26:13 response creates both therapeutic applications and management challenges in prostate cancer where tumor growth is 26:20 typically androgen dependent and the ultimate goal is testosterone suppression. However, the initial 26:27 testosterone surge during the flare phase can temporarily worsen symptoms potentially causing increased bone pain, 26:34 urinary obstruction, or even spinal cord compression in patients with metastatic 26:40 disease. This is why uh luoprolide is often started with an anti-ad androgen 26:47 like bicladamide for the first two to four weeks to block the effects of the 26:52 testosterone surge. The FDA has approved lupalide for multiple indications across 26:59 formulations. In oncology, it’s used for palletive treatment of advanced prostate cancers. In gynecology, various 27:06 formulations are approved for endometriosis, for pain management and lesion reduction and for fibroids. 27:13 Typically for pre-operative uh hematological improvement in anemic patients. In pediatrics, it’s used for 27:20 central precocious p puberty basically to halt the premature sexual development of these young people. Now, there are 27:28 adex uh adverse effect profile that reflects profound hormonal suppression. 27:34 In men treated for prostate cancer, hot flashes affect about 59% of the patients. Other common effects include 27:41 general pain, swelling, bone pain. Um long-term use of these medications leads 27:47 to metabolic changes. It increases fat mass. It decreases lean mass. It worsens 27:53 insulin sensitivity, disrupts the cholesterol uh lipid panels, increases 27:59 diabetic risk, has some concerns over cardiovascular disease. And the metaanalysis have shown increased risks 28:06 of heart infarction, myocardial inffection, sudden cardiac death, and stroke in populations receiving 28:13 long-term androgen deprivation therapy. The bone effects are particularly dramatic. Without sex hormones, bone 28:20 density decreases significantly, typically 3 to 4% per year during the 28:26 first two to three years of therapy. And this bone loss may not fully be reversible after the the therapy 28:32 discontinues. The American Society of Clinical Oncology recommends bone density monitoring and consideration of 28:39 bisphosphinates uh in men receiving long-term androgen deprivation. In women treated for 28:46 endometriosis or fibroids, the estrogen suppression creates a hypoestrogenetic state similar 28:54 to menopause. Hot flashes affect 90% of patients with other common effects 29:00 including headaches, emotional irritability, decreased sex drive, vaginal dryness, bone density loss. And 29:08 because of these bone concerns and treatment duration with endometriosis, typically limited to six months, though 29:14 some formulations allow for longer use with adback hormonal therapy to 29:20 partially mitigate these side effects. The mood and cognitive effects can be s 29:25 significant. I’ve seen it over the years. the depression, the memory impairment, difficulty focusing and 29:31 concentrating. It can be very very traumatic and the quality of life that 29:37 happens for these uh women and men can be unbearing for many of them. Um, from 29:44 an integrative perspective, patients receiving this medication need comprehensive support care. Bone health 29:51 interventions using calcium, vitamin D, vitamin K2, weightbearing exercise, 29:58 cardiovascular risk management becomes critical, including blood pressure monitoring, lipid management, diabetes 30:05 screening. For hot flashes management, some patients respond to black coohos, 30:10 sage, or vitamin E. Though evidence is mixed and individual response varies, 30:16 omega-3s may help with the mood and the inflammation, resistance training becomes specifically important to 30:22 preserve lean muscle mass in the face of hormonal suppression. 30:27 Now there’s something called calcetonin salamon which is marketed as miaelin. 30:34 It is a nasal spray. It is now discontinued. And foral is the new 30:39 synthetic polyeptide hormone of 32 amino acids identical to calcetonin of salamon 30:47 origin. It represents an interesting case study in how initial promise gives 30:52 way to safety concerns that regulate a therapy to historical footnote status. 30:58 Calcetonin is naturally occurring hormone in humans. It’s secreted by the paraphalicular sea cells in the thyroid 31:04 gland. Its primary physiological role is to lower blood calcium levels by 31:10 directly inhibiting osteoclast activity, reducing bone reabsorption, increasing 31:16 renal calcium secretion or excretion, and possibly reducing the intestinal 31:21 calcium absorption. So, salamon calcetonin is used therapeutically because it’s more potent and longer 31:27 acting than human calcetonin. The FDA initially approved calceton and salmon 31:34 for several indications post-menopausal osteoporosis in women more than five 31:39 years post-menopausal when alternative treatments are not sustainable. Padet’s 31:44 disease for bone and hypercalcemium as emergency treatments. The nasal spray formulation is particularly popular for 31:53 osteoporosis because it offered a non-injectable alternative to bisphosphinates. 31:58 However, in 2012, the European Medicine’s Agency, EMA, conducted a 32:05 comprehensive safety safety review after a poolled analysis of 21 clinical trials 32:10 involving over 10,000 patients showed a statistically significant increase in 32:15 malignancy risk in patients treated with calceton salamon compared to compared to 32:21 placebo. The overall malignancy rate was 4.1% in calcetonin treated patients 32:28 versus 2.9% in placebo patients. The types of cancer 32:34 varied with no single cancer type predominating, making it difficult to establish a clear mechanistic link. 32:41 However, the signal was concerning enough that the EMA restricted the use of calcetonin containing medicines. In 32:48 the United States, the FDA issued communications about malignancy signal and conducted its own review. While they 32:56 didn’t fully withdraw the drug, the cons consensus shifted dramatically. The nasal spray formulations miaelson was 33:03 voluntarily discontinued by the manufacturer and current clinical practice guidelines now consider 33:10 calcetonin salamon as a second line or lower option for osteoporosis. While 33:15 behind bisphosphinates, dennism mob, uh, terrapeptide, the analesic effect of 33:21 calcetonin in bone pain, particularly in acute vitibbral, uh, compression 33:26 fractions from osteoporosis or pageantss disease may still provide a role for short-term use in these selected 33:32 patients. The mechanism of this pain relief is unclear, but may involve 33:38 effects of endorphin systems and/or direct actions on pathways. The history serves as an important reminder in 33:45 peptide medicine. Initial approval and early clinical use does not guarantee 33:50 long-term safety effects. Post marketing surveillance and poolled analysis of the clinical trial data can reveal adverse 33:58 effects that weren’t apparent in initial studies. It also underscores why newer 34:04 agents with better safety profiles um have largely replaced calcetonin in 34:10 clinical practice. So this is really an important thing. Not one thing stays the same forever. We have to change as we 34:18 identify new and better products as we identify problems and concerns. I will 34:24 always tell my patients if you are uncertain of taking a new drug which we 34:30 all should be wait five years. Within five years we are going to find the 34:36 problems that they didn’t find in the clinical studies. Remember, a lot of these clinical studies are small, small 34:43 groups, short periods of time. It’s expensive to do these trials. So, if you 34:49 wait for five years, in the first two to three years, you will see the problem start to emerge. And what are you going 34:55 to look for? You’re going to look for the the news um commercials from lawyers 35:02 suing a drug. And they will tell you what the problem is. and then you can decide, is this something that I want to 35:09 use or not. Don’t jump on bandwagon and be the first one to do this, especially 35:14 if you’re sensitive. You know, give it time so you can see exactly what’s going on. So, I’m going to end our show on 35:22 this and we are going to pick up on part three of peptide therapy in our next 35:28 segment where we’re going to talk about the investigational peptides and some 35:34 exciting things that are happening with that. So, I want to thank you for joining me today on Let’s Talk Wellness 35:39 Now. It’s always a pleasure having a conversation with you guys and I hope this brings value to you with what we’re 35:45 talking about. If you have ideas for topics that you want me to discuss, 35:51 please message us, you can share your comments on Facebook, you can email us, 35:58 um you can get a hold of us however you would like to share that. I do look at the comments below in the episodes as 36:04 well. So you can place your comments there. And once again, one of the best things you can do for me is like, 36:11 subscribe, and share so that we can spread the messages of what we’re doing. 36:16 I do this at no cost. I don’t make any money out of this. I do this as an 36:21 educational purpose for everybody else. I love doing it, but it really helps us 36:28 on the algorithms if you would be just willing to like, subscribe, and share. 36:33 So, thank you for spending your time with me. I know time is important.The post Episode 257 – Peptides for Sexual Wellness & Hormonal Health: PT-141, Growth Hormones, Bone Health & More! first appeared on Let's Talk Wellness Now.

With dangerous medical advice taking over social media, peptides are bleeding from niche biohacking and "gym bro" communities into the mainstream. This week, Chloe breaks down the science, the risks, and why the "magic medicine" mindset around unauthorised injectables is dangerous. In this episode Chloe covers: What Peptides Actually Are: Short chains of amino acids that act as signaling molecules (like insulin and GLP-1) to tell your cells what to do. Approved Peptides: A look at legal, heavily tested peptides (like GLP-1s and Insulin) and why their knock-on metabolic effects require strict medical supervision. Unapproved & Unproven Peptides: The massive risks behind unauthorized, internet-bought compounds like BPC-157 and TB-500, including a harrowing case study. Inherently Risky Peptides: Debunking the muscle-growth myths around IGF-1 and Growth Hormone Secretagogues, and exposing their severe cardiovascular and insulin resistance risks. The Bottom Line: Why you should always steer clear of unauthorized injectables, plus a recommendation to check out the Barbell Medicine podcast for a deeper dive into the clinical science. Don't forget to like, subscribe, rate, and review the Bodcast! It helps others find the podcast more easily. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Dairy is one of the most misunderstood foods in wellness. Is it inflammatory? Does it increase mucus? Does it raise IGF-1 and breast cancer risk? Or is that fear-based messaging? In Part 4 of the Nutrition Just the Facts series, Laura breaks down the science behind dairy and separates cultural belief from biological evidence. This episode covers: • Dairy and inflammatory biomarkers • The mucus myth • IGF-1 and growth signaling in breast cancer • Lactose intolerance versus milk allergy • A1 versus A2 milk • Grass-fed versus conventional dairy • The influence of marketing and dietary policy This is a calm, research-grounded conversation designed to help you make confident, personalized nutrition decisions.   Let's Connect! If this episode helped you breathe a little easier, please share it with a friend or leave a review. Every share helps spread this message of hope, healing, and whole-person wellness.

Most people fear cancer, but they're never given a clear explanation of what it actually is, how it progresses, or why metastasis, not the initial tumor, is what kills 90% of people with solid tumors. And here's what almost no one talks about…30 minutes of exercise per day can down-regulate 13 types of cancers. I break down the biology of cancer and metastasis in plain language, then walk you through the evidence linking exercise to cancer outcomes across prevention, treatment, and survivorship. I explain how cancer cells have to physically enter circulation and survive a hostile journey to metastasize, and here's the part that changed how I think about high-intensity exercise: as shear stress increases during vigorous exercise (zone 5, 90%+ max heart rate), survival of circulating tumor cells decreases. I also cover immune surveillance, metabolic signaling, and why this is deeply personal for me. Reduce your risk of Alzheimer's with my science-backed protocol for women 30+: https://go.neuroathletics.com.au/youtube-sales-page Subscribe to The Neuro Experience for evidence-based conversations at the intersection of brain science, longevity, and performance. Topics Discussed 00:00 Intro: Why Cancer Is What Scares Me Most 01:37 Why We're Having This Conversation 03:33 What This Episode Covers: The Three-Part Framework 06:21 What Cancer Actually Is: When Cells Break the Rules 07:25 Metastasis: The Part of the Story No One Explains 27:57 Shear Stress and Circulating Tumor Cells: The Zone 5 Effect 30:16 Immune Surveillance: How Exercise Mobilizes Killer Cells 30:51 Metabolic Signaling: Insulin, IGF-1, and Inflammation 32:16 Limitations: What the Evidence Can and Can't Tell Us 34:37 Practical Framework: Prevention, Treatment, and Survivorship 36:04 Closing: Exercise as Repeated Physiological Stress Thank you to our sponsors Ketone-IQ: https://ketone.com/NEURO IQ BARS: Text NEURO to 64000 to get 20% off all IQBAR products Cure Hydration: http://curehydration.com/NEURO Cellure: https://cellure.co/ and use code NEURO Arrey: https://arey.com/ and use code NEURO _______ I'm Louisa Nicola - clinical neurophysiologist - Alzheimer's prevention specialist - founder of Neuro Athletics. My mission is to translate cutting-edge neuroscience into actionable strategies for cognitive longevity, peak performance, and brain disease prevention. If you're committed to optimizing your brain- reducing Alzheimer's risk - and staying mentally sharp for life, you're in the right place. Stay sharp. Stay informed. Join thousands who subscribe to the Neuro Athletics Newsletter → https://bit.ly/3ewI5P0 Instagram: https://www.instagram.com/louisanicola_/ Twitter : https://twitter.com/louisanicola_ Learn more about your ad choices. Visit megaphone.fm/adchoices

Can something as simple as changing when you eat actually influence inflammation, immune function, and cellular repair?Fasting is often portrayed as either a miracle cure or a dangerous trend. But what does it really do inside the body, especially if you're facing a chronic or serious illness?In this episode of Renegade Remission, we explore the real science behind fasting and metabolic therapy.You'll learn what happens biologically when the body shifts its fuel source, how fasting influences autophagy and inflammation, and why some long-term survivors include gentle metabolic strategies as part of their healing approach.We'll also examine a documented glioblastoma case in which metabolic therapy was used alongside conventional treatment, not as a replacement, but as a supportive layer. This conversation cuts through hype and fear to give you clarity.In this episode, you'll discover:What autophagy is and why it matters for cellular repairHow time-restricted eating can stabilize blood sugar and reduce inflammatory stressWhy ketones act as signaling molecules, not just fuelThe connection between glucose spikes and immune dysfunctionHow short-term fasting influences IGF-1 and cellular stress resistanceWhy most benefits come from gentle shifts, not extreme deprivationMost importantly, you'll learn how to support your metabolic health in ways that feel sustainable and safe, without rigid rules, starvation, or added stress on your body.Listen now to understand whether fasting or metabolic strategies might be supportive on your healing journey and how to implement simple, safe shifts starting today.If you are navigating cancer, autoimmune disease, neurological illness, heart disease, or another serious diagnosis, this episode will help you approach metabolic therapy with clarity instead of confusion.DisclaimerThis podcast is for educational purposes only and does not provide medical advice. Always consult your licensed healthcare provider before making changes to your diet, fasting practices, or treatment plan. Fasting is not appropriate for everyone, especially those who are underweight, medically fragile, pregnant, or undergoing active treatment without supervision.This podcast explores science and stories related to cancer, MS, ALS, dementia, Alzheimer's, heart disease, autoimmune conditions, chronic illness, terminal diagnoses, metabolic therapy, integrative medicine, lifestyle medicine, and remission, offering grounded hope and practical tools for resilience and renewal.

Rob, Doug, Andy, and Sarah chat with Gabe Cuzzillo (Ape Out, Despelote) and Bennett Foddy (Getting Over It with Bennett Foddy, QWOP) about their (with Maxi Boch) latest game, the multi-IGF-nominated open-world hard-walking manchild simulator Baby Steps. We discuss the game's in-house approach to voice acting, balancing challenge with humor, creating (and hiding) a looping environment, telling an honest story about masculinity, including explicit content without getting banned from Steam, rock curation, secrets, and so much more! Audio edited by Dylan Shumway Discussed in this episode: Baby Steps https://www.babystepsgame.com/ Dr. Katz, Professional Therapist https://www.imdb.com/title/tt0111942/ My Summer Car https://store.steampowered.com/app/516750/My_Summer_Car/ zk map (for stranger) https://www.glorioustrainwrecks.com/node/11388  La belle noiseuse (1991) https://www.imdb.com/title/tt0101428/ Kelly Reichardt https://www.imdb.com/name/nm0716980/ Perfect Days (2023) https://www.imdb.com/title/tt27503384/ The Taste of Things (2023) https://www.imdb.com/title/tt19760052/ NYU Game Center Lecture Series Presents Jane Ng https://www.youtube.com/watch?v=3yWIoRuwpm0  DESPELOTE: FIFTH TRAILER (now on nintendo switch) https://www.youtube.com/watch?v=_MXKlgMZ3Jc The Love That Remains (2025) https://www.imdb.com/title/tt33381401/ Solo (Australian ad) 1983 https://www.youtube.com/watch?v=CCkz0JsaU8k Solo Man ad, Australia 1986 https://www.youtube.com/watch?v=6T3RS78Tp58 Solo (Australian ad) 1984 https://www.youtube.com/watch?v=N_1nZZrv8aU  Frog Detective 3 https://store.steampowered.com/app/1171320/Frog_Detective_3_Corruption_at_Cowboy_County/  https://secretlives.games  https://discord.gg/tslog https://www.patreon.com/tslog

In this clip from Bathroom Diaries, Dr. Sofia Din and Dr. Rob Frankel break down one of the most common mistakes people make with peptides: thinking one peptide can fix everything. Using a simple and hilarious analogy — "asking for one peptide is like going to a tire shop and buying just one tire" — they explain why peptides work best as a system, not a single quick fix. If you're curious about how peptides actually work, which combinations make sense, and why personalized protocols matter, this highlight is a must-watch.

Sardines are one of the most nutrient-dense, anti-inflammatory foods you can eat, but does eating only sardines actually count as fasting?     On today's show, I break down the growing trend of "sardine fasting," explain why it's gaining popularity, and clarify the key differences between true fasting, fasting-mimicking diets, and simply following a low-calorie, high-protein plan.     You'll learn why sardines, while incredibly healthy, do not lower IGF-1 or activate AMPK, why that matters for longevity and autophagy, and when a sardine-only day may—or may not—make sense depending on your goals.     Join me on today's Cabral Concept, Episode 3646, to find out whether the sardine fasting diet really works and what you can do instead to achieve better results.     Enjoy the show! - - - For Everything Mentioned In Today's Show: StephenCabral.com/3646 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

HEALTH NEWS A Simple Diet Change Could Slow Liver Cancer Brief, intensive exercise helps patients with panic disorder more than standard care Lucid dreaming could be used for mental health therapy, new study says US cancer institute studying ivermectin's ‘ability to kill cancer cells Too many saturated fats may be more harmful than too many refined carbohydrates.    Clips   Andrew Bridgen - https://x.com/ABridgen/status/2020573528571977993?s=20 MAHA Alliance Mike Tyson Super Bowl Commercial - https://www.youtube.com/watch?v=jg1SjFt1a_U   KETO DIET RISKS    The rationale for Keto Diet by its advocates Restricting carbohydrates, suppressing insulin and ketosis will lead to better metabolic heath, increase weight loss, reduce inflammation, and protect from chronic diseases.   Keto Claim: Carbohydrates raise insulin leading to fat storage – keto lowers insulin and burns body fat better Debunking: Ketosis is a metabolic state and not a health outcome. For example ketones can be elevated by very long fasting, starvation, different illnesses and uncontrolled diabetes.   Keto Claim: By minimizing carbs keto stabilizes blood sugar, reduce insulin spikes, and improve insulin sensitivity that benefits those with type 2 diabetes Debunked: This claim contradicts the evidence of induced hepatic insulin resistance and glucose intolerance in longer-term studies. In animal models, keto diets impair blood sugar regulation within several days, which shows harm for metabolic health.   Keto Claim: Ketones are seen as “clean” fuel that advocates claim are anti inflammatory and neuroprotective. Believe that this along with ketosis lowers triglycerides, raises HDL cholesterol, and improves lipid profiles. They argue that the increase in LDL cholesterol is benign. Claim saturated fats are harmless if carbs are low Debunked:  This claim is undermined by the increased LDL cholesterol, triglycerides, and cardiovascular risks from saturated fats in animal products. Meta-analyses show no long-term lipid improvements from keto diets. Rather this is the risk in elevated low-density lipoprotein and very-low-density lipoproteins that increase cardiovascular disease  Also, insulin reduction does not override the quality of fat. LDL cholesterol and ApoB, as well as atherosclerosis, increase significantly on an animal based diet. Saturated fat still remains a causal factor for cardiovascular disease.   Keto Claim: High protein and fat increases satiety and therefore reduces hunger Debunking: Weight loss is primarily from reduced intake due to satiety, not fat-burning efficiency. Long-term keto adherence often leads to weight regain with no significant sustained benefits for visceral fat or appetite control. hort term weight loss is not same as long term benefits. A study shows that weight loss at 3-6 months on a keto diet disappears by 12 months   Keto Claim: It enhances brain function and energy that then improves mental clarity and mood. Argue that animal products like eggs and organ meats provides choline and other nutrients for brain health. Debunked: There is no strong evidence for this claim. In fact keto's nutrient deficiencies and lack of fiber in the long term can lead to fatigue, constipation and in women neural tubal defects. Keto's claims are only based on short term trials.    Keto Claim: Use the evolutionary argument that humans evolved eating meat and fat – same argument the paleo folks used. Therefore, they believe keto diets align with human biology Debunked: A big study in Science in 2025 analyzed tooth enamel from skeletons of some of our oldest human ancestors, 3.5 million years ago, and found they ate predominately a plant based diet with no substantial sigh of mammalian meat. The isotopes matched herbivores (fruits, leaves and grasses, tubers, nuts, other vegetation) not carnivores.     Keto Diet Risks   It is worth noting, according to the Northwestern University Health site, there is a sizable drop out rate of participants in keto trials.   Although, there are studies that show keto does what it claims in the short term, there are no long-term human data to support their claims that an animal-based diet does this efficiently.   Important, research leans in the direction to indicate that keto's benefits – especially weight loss and glucose reduction, are transient and may not be directly related to animal food consumption itself but rather to calorie reduction and limiting glycogen.   Long term prospective studies and systematic meta analysis evaluations consistently show high red meat consumption, full-fat dairy and animal fats are associated with the following medical conditions. This is true even when carbohydrate intake is low   A good thorough study in JAMA shows that unprocessed red meat mildly increases all cause mortality – about 3-5% per 100 grams meat per day   High red and processed meat consumption increases carcinogenic N-nitroso compounds and heterocyclic amines that raise cancer risks by up to 18% per 50-100 grams/day – from meta analysis in the European Journal of Epidemiology   Dairy increases IGF-1 levels thereby too much calcium also suppressing Vitamin D and elevating prostate cancer risks by 79% per 400 gram dairy per day. Worse for processed meats that inreases risk by 21% per 20 grams/day – American Journal of Epidemiology   Red meat is linked to hormonal disruptions and carcinogens contributing breast cancer – European Journal of Cancer   Total unprocessed red meat consumption shows a modest 5% risk in pancreatic cancer per 100 grams/day. – From journal Clinical Nutrition   Many meta-analyses on meats have a relationship to stomach/gastric cancer, but processed meats are worse than unprocessed red meat. From study in Nutrients – 24 studies showed unprocessed red meat associated with gastric cancer by about 25% increase risk for every 100 grams/day.   Unprocessed red meat is linked to an 11% higher risk in overall cardiovascular disease risk due to inflammation and endothelial dysfunction. – from European Heart Journal   Saturated fats in meats increases non-HDL cholesterol and blood pressure and raises the risks of ischemic heart disease by 119% per 100 grams/day red meat – from American J Clinical Nutrition   Red meat diets reduce LDL Cholesterol much less than plant proteins and thereby increase atherosclerosis risks – from the journal Circulation   Red meats (an processed meats also in this study) contributes to insulin resistance via heme iron and raises Type 2 diabetes risks by up to 51% per 50 grams/day – International Journal Environmental Research in Public Health   Saturated fats in unprocessed red meat has a modest positive 12% increase with stroke risk – From  European Heart Journal Unprocessed poultry consumption shows a modest 4% increase in incident cardiovascular events per 100 grams/day. This is believed to be due to arachidonic acid poultry – in JAMA   Red meat contributes to sodium and saturated fat intact raising hypertension conditions by 14% per 50-100 gram/day – from journal Advanced Nutrition   Saturated fats from animal products cause lipotoxicity and insulin resistance, that promotes hepatic fat accumulation leading to non-alcoholic fatty liver disease – from Cardiovascular Development and Disease   High animal protein increases urinary calcium and acid overload leading to the formation of kidney stones – from the journal Nutrient   Animal-heavy diets have low fiber and micronutrient intake that contribute to nutrient deficiencies. Also causes constipation that can lead to immune system issues. – from the journal Nutrients   Red meat, dairy, and eggs disrupts the gut metabolism of carnitine and choline. This promotes TMAO plaque formation and inflammation that leads to atherosclerosis. – from Journal of Cardiovascular Development.   Although unprocessed meat consumption has not been adequately associated with dementia and Alzheimer's – yes, processed meats do – there are studies showing red meat is associated with “subjective cognitive decline” (SCD) which is related to precursors to dementia and Alzheimer's. A study in journal Neurology  links unprocessed red meat eaten at 1 or more servings per day to 16% higher risk in SCD.   High caloric density from saturated animal fats displaces fiber that contributes to weight gain obesity. From Neal Barnard in the American Journal of Clinical Nutrition   Animal products transmit prions that are associated with neurodegenerative disorders.  Proinflammatory compounds like TMAO are linked to neurological risks. – in International Journal of Molecular Science

Can fasting actually weaken cancer — and make chemotherapy work better?In this episode of Integrative Cancer Solutions, Dr. K sits down with longevity and nutrition science pioneer Dr. Joseph Antoun to break down the emerging research on fasting, fasting-mimicking diets, and precision nutrition for cancer. Dr. Antoun explains why cancer thrives on growth signals, how traditional “eat more calories” advice may backfire, and what the science really says about starving cancer while protecting healthy cells.This conversation explores fasting-mimicking nutrition before chemotherapy, immune rejuvenation, autophagy, growth factors like insulin and IGF-1, muscle preservation, and why food-as-medicine may dramatically improve treatment tolerance and outcomes. If you or someone you love is navigating cancer — or wants to reduce risk through longevity-based nutrition — this episode delivers critical, science-backed insights you won't hear in a standard oncology visit.Key Takeaways:0:00 Introduction and why nutrition matters in cancer6:10 Starving cancer while protecting healthy cells9:20 Fasting-mimicking diets vs water fasting12:45 How fasting sensitizes cancer to chemotherapy16:30 Immune system rejuvenation and autophagy explained21:00 Nutrition strategies after cancer treatment for longevityResources Mentioned:L-Nutra / ProLon® Fasting Mimicking Diet - https://www.l-nutra.comL-Nutra Health – Diabetes & Nutrition Programs - https://www.lnutrahealth.comThe Longevity Diet by Valter Longo - https://www.valterlongo.comCREATE Cures Foundation (USC Longevity Clinics) - https://createcures.org -----------------------------------------------A Better Way to Treat Cancer: A Comprehensive Guide to Understanding, Preventing and Most Effectively Treating Our Biggest Health ThreatGrab my book here: https://www.amazon.com/dp/B0CM1KKD9X?ref_=pe_3052080_397514860 Unleashing 10X Power: A Revolutionary Approach to Conquering CancerGet it here: https://store.thekarlfeldtcenter.com/products/unleashing-10x-powerPrice: $24.99100% Off Discount Code: CANCERPODCAST1 Healing Within: Unraveling the Emotional Roots of CancerGet it here: https://store.thekarlfeldtcenter.com/products/healing-withinPrice: $24.99100% Off Discount Code: CANCERPODCAST2-----------------------------------------------Integrative Cancer Solutions was created to instill hope and empowerment. Other people have been where you are right now and have already done the research for you. Listen to their stories and journeys and apply what they learned to achieve similar outcomes as they have, cancer remission and an even more fullness of life than before the diagnosis. Guests will discuss what therapies, supplements, and practitioners they relied on to beat cancer. Once diagnosed, time is of the essence. This podcast will dramatically reduce your learning curve as you search for your own solution to cancer. To learn more about the cutting-edge integrative cancer therapies Dr. Karlfeldt offer at his center, please visit www.TheKarlfeldtCenter.com

Watch the FULL podcast here: https://youtu.be/qHFymGgsYyECan you do everything right and still face Alzheimer's risk? It can happen, and we discuss how environmental toxins, metabolic health, and shifting hormones may play a role. This clip explores two grandmothers with opposite lifestyles, highlighting possible factors like hemoglobin A1c, menopause-related drops in estrogen, and other hormones including IGF-1 and thyroid. We also consider genetic resilience and detox capacity, and why relying on luck isn't wise. Women are addressed directly, with advice to see a good hormone doctor during perimenopause and menopause. ***This episode is sponsored by:NOWATCH: The compassionate health trackerConnecting body and mind with unique stress recovery insights so you can live fully today15% off with code LWBW15 at https://nowatch.com/Mojo: the app for expert-led courses in better sex.Learn from world-class sex therapists and relationship experts with courses tailored to your needs.15% off with code LiveWell15 at mymojo.com/livewellbewell***The Great British Veg OutHow to support your gut, energy, and hormones by eating more — not less.

In this episode, Dr. Geo is joined by Dr. Steven Freeland to discuss the powerful intersection of urologic oncology and metabolic health. Dr. Freeland shares groundbreaking research on how dietary interventions—specifically low-carbohydrate protocols—can slow prostate cancer progression and counteract the metabolic damage caused by standard treatments like Androgen Deprivation Therapy (ADT).In This Episode, You'll Learn:The Metabolic Growth Signal: Why insulin and Insulin-like Growth Factor 1 (IGF-1) are considered "fuel" for prostate cancer cells and how reducing sugar can starve that signal.The 20-Gram Protocol: Insights from Dr. Freeland's study on ultra-low-carb diets, where participants saw a 20-pound weight loss and a significant slowing of PSA doubling time.Combatting ADT Side Effects: How a metabolic approach can improve insulin resistance by 30% and surprisingly help preserve bone density during hormone therapy.The "Slim-Fat" Reality: Why your BMI might be normal, but your visceral fat (adiposity) could still be driving inflammation and cancer growth.Clinical Markers to Watch: Why patients should ask about HOMA-IR (Insulin Resistance) and Hemoglobin A1C rather than just focusing on PSA alone.Key Quotes from the Episode:"Lifestyle intervention isn't alternative medicine; it is metabolic medicine." — Dr. Steven Freeland"Cancers need the same nutrients the body needs to grow. If we're reducing pro-growth stimuli to the whole body through weight loss and low carbs, it makes sense we're reducing it to the cancer." — Dr. Steven FreelandResources & Links Mentioned:Dr. Steven Freeland: Cedars-Sinai Faculty ProfileResearch Paper: Ultra-low carbohydrate diet and prostate cancer progression (referenced as the "20-gram study").Recommended Diet Protocol: Induction Phase Atkins (as used in the clinical trials).Clinical Markers: * HOMA-IR: (Fasting Insulin $times$ Fasting Glucose) / 405 (or 22.5 in SI units).Hemoglobin A1C: A 90-day average of blood sugar levels.Wearables: Fitbit, Oura Ring, and Whoop (discussed in the context of tracking "active steps" and sleep quality).Episode Breakdown by Timestamp:[07:35] Breaking down the 20-gram carbohydrate trial and patient adherence.[13:45] The impact of...

In this video, I review sermorelin, a growth hormone–elevating peptide, and explain where it fits physiologically within the growth hormone axis. I begin by defining what peptides are and what is meant by a growth hormone–elevating peptide, then clarify what sermorelin is — and what it is not. HOW SERMORELIN WORKS, Sermorelin is a synthetic analog of growth hormone–releasing hormone (GHRH). It acts at the level of the pituitary gland to stimulate endogenous, pulsatile growth hormone secretion, rather than providing exogenous growth hormone. I discuss the downstream effects of growth hormone signaling, including its role in: ❇️ sleep regulation ❇️ bone metabolism ❇️ muscle and body composition ❇️ skin integrity ❇️ cognitive function I also address a common question: Why don't we simply administer growth hormone? This section reviews the physiologic risks of bypassing hypothalamic–pituitary regulation, including suppression of natural hormone signaling and elevations in IGF-1. Finally, I conclude with an overview of clinical considerations surrounding administration, including dosing, timing, and cost. My goal is to help you understand where sermorelin fits within normal hormone physiology, so you can make informed, thoughtful decisions about your care. If you would like a physician-guided evaluation, you can visit us at Complete Midlife Wellness Center https://completemidlifewellnesscenter.com

STOP intermittent fasting if you think it automatically keeps you young. In this episode, you'll learn why short-term fasting results can mislead long-term aging outcomes, and how duration, frequency, refeeding, and protein intake determine whether fasting supports longevity or quietly accelerates decline. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Valter Longo, one of the world's leading longevity researchers with over 30 years of experience studying aging, nutrition, and disease prevention. Dr. Longo is the Director of the Longevity Institute at the University of Southern California's Leonard Davis School of Gerontology and the Director of the Longevity and Cancer Program at IFOM, the Italian Foundation for Cancer Research Institute of Molecular Oncology in Milan. He is the author of the bestselling book The Longevity Diet and was named one of TIME Magazine's 50 most influential people in health care for his research on fasting-mimicking diets. Together, Dave Asprey and Dr. Longo explain why many people focus too heavily on short-term effects and extrapolate them incorrectly across a lifetime. They break down how intermittent fasting differs biologically from multi-day fasting, why five-day fasting cycles trigger deeper cellular changes, and how insulin, IGF-1, mTOR, and growth hormone shape aging, regeneration, and disease risk over time. The conversation covers protein and amino acid intake, muscle preservation, frailty risk, and the tradeoffs between strength, function, and longevity. They explore ketosis, fasting-mimicking diets, stem cell activation, mitochondrial function, neuroplasticity, and why equilibrium and cycling matter more than constant restriction. Dave and Valter also discuss supplements, nootropics, creatine, carnivore-style eating, metabolism, sleep optimization, and how AI may eventually personalize fasting and nutrition based on individual biology rather than population averages. You'll learn: • Why short-term fasting benefits do not predict long-term longevity • How fasting duration changes gene expression and cellular regeneration • The difference between intermittent fasting and multi-day fasting • How protein and amino acids influence mTOR, IGF-1, and aging • Why muscle, strength, and longevity must be balanced, not maximized • When ketosis overlaps with fasting and when it does not • Why supplements can disrupt biological equilibrium • How AI could support future personalization in fasting and nutrition Dave Asprey is a four time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Thank you to our sponsors! • BEYOND Conference 2026 | Register now with code DAVE300 for $300 off at https://beyondconference.com/• AquaTru | Go to https://aquatruwater.com/daveasprey and save $100 on all AquaTru water purifiers.• Caldera + Lab | A small habit with big results. Go to https://CalderaLab.com/DAVE and use code DAVE for 20% off your first order.• Timeline | Go to https://timeline.com/Dave for 20% off.Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: intermittent fasting longevity, fasting mimicking diet, fasting and aging science, biohacking fasting podcast, longevity fasting research, protein restriction longevity, amino acids aging, mTOR IGF-1 longevity, mitochondria aging science, neuroplasticity fasting, ketosis fasting science, metabolism longevity podcast, anti-aging fasting, functional medicine longevity, supplements fasting debate, nootropics brain optimization, muscle frailty aging, sleep optimization longevity, AI personalized nutrition, carnivore diet longevity debate, Dave Asprey fasting, Valter Longo longevity, longevity diet podcast, human performance aging Resources: • Learn More About Valter's Work At: https://valterlongo.com/ • Join My Fasting Challenge: https://daveasprey.com/#14-day • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Join My Low-Oxalate 30-Day Challenge: https://daveasprey.com/2026-low-ox-reset/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com Timestamps: 0:00 Introduction & Aging Fundamentals 4:36 Fasting Mimicking Diet Overview 7:03 Insulin, IGF-1 & mTOR 11:03 Body Fat & Fasting Frequency 17:08 The Protein Debate 20:22 Blue Zones & Centenarian Evidence 23:10 Amino Acids & Leucine 30:30 Growth Hormone & Longevity 34:01 Five-Day Fasting Benefits 40:55 Personalization & AI 42:29 Plant-Based Concerns 49:07 Fasting Risks & Limits 53:05 Supplements & Equilibrium 1:03:05 Ranking Longevity Pathways 1:05:05 Modern Environmental Challenges 1:16:21 Final Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In Dr Cabot's latest podcast, she talks all about the liver and how a sluggish liver can cause fatigue. The liver manages the body's energy supply, and the Chinese call the liver The General of the Army of the Body. Not only does the liver create energy, but it also manufactures and secretes specific compounds such as bile and IGF-1, as well as removing and neutralising substances that are toxic to the body. In this way, the liver is our great protector by helping us to fight infection and protect our immune system from overload. To add to the liver's many functions, it also acts as a warehouse for  vitamins A, D, E, K, B12 and the minerals iron and copper, as well as regulating our hormones.  Visit Dr Cabot website to find out more about Dr Cabot (spoiler alert, she's also a pilot!), to access her Weight Loss Detective Program, podcasts, videos, article and testimonials:https://www.sandracabot.com/Visit Dr Cabot's Australian website for the Cabot Health supplement range, books, health articles, recipes and free downloads:https://www.cabothealth.com.au/Visit Dr Cabot's US website for the Liver Doctor supplement range, books, health articles, recipes and free downloads:https://www.liverdoctor.com/

These Border Patrol raids deep in our cities are nothing but a massive beta test for the AI surveillance grid, with feds wearing Meta glasses that snap your face, ID you instantly, and feed you into kill lists just like they did to Alex Pretti before they executed him on camera. Erika Kirk wants you to buy her grieving trad-wife act, but the receipts don't lie—she's a documented pathological liar who faked her entire backstory, hid ex-fiancés and wild reality-TV hookups, invented a single-mom sob story, and buried inconvenient family members while pretending to be some pure Christian conservative princess.

Sardines are one of the most nutrient-dense, anti-inflammatory foods you can eat, but does eating only sardines actually count as fasting?     On today's show, I break down the growing trend of "sardine fasting," explain why it's gaining popularity, and clarify the key differences between true fasting, fasting-mimicking diets, and simply following a low-calorie, high-protein plan.     You'll learn why sardines, while incredibly healthy, do not lower IGF-1 or activate AMPK, why that matters for longevity and autophagy, and when a sardine-only day may—or may not—make sense depending on your goals.     Join me on today's Cabral Concept, Episode 3646, to find out whether the sardine fasting diet really works and what you can do instead to achieve better results.     Enjoy the show! - - - For Everything Mentioned In Today's Show: StephenCabral.com/3646 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

These federal goons just publicly assassinated Alex Pretti—an ICU nurse who dared step in when they were brutalizing American women—yanking his gun, pistol-whipping him, and executing him on video while the whole country watches. Jon Miller joins the show to expose how Pam Bondi and the entire Trump crew are spitting on the Epstein Files Transparency Act, protecting the pedophiles who blackmail and rape kids while they run our government.

How does breakthrough brain science become real treatment for patients? In this episode, we sit down with Dr. Daniela Tropea, Associate Professor of Molecular Psychiatry at Trinity College Dublin, to explore how cutting-edge neuroscience research is being translated into life-changing therapies for mental health and neurodevelopmental disorders. As the leader of Trinity's Translational Neuroscience Laboratory, Dr. Tropea has helped reshape our understanding of brain plasticity and growth factors — including her influential work on insulin-like growth factor 1 (IGF-1). Her research directly contributed to the development of Trofinetide, the first FDA-approved treatment for Rett Syndrome, and continues to inspire new therapeutic possibilities for conditions like Fragile X and Phelan-McDermid Syndrome. In this conversation, we dive into: ·       How fundamental neuroscience discoveries turn into real-world treatments. ·       The future of personalized medicine in mental health care. ·       Why mentorship, diversity in research, and public outreach matter for scientific progress. ·       How brain plasticity research could change the way we treat complex disorders. Dr. Tropea is also a celebrated educator and international collaborator, recognized for innovation in teaching and mentorship — and for making complex science accessible to broader communities. Want to explore more of her work? Visit her profile at Trinity College Dublin, review her latest neuroscience publications, or connect with her directly via email: Daniela.Tropea@tcd.ie Episode also available on Apple Podcasts: https://apple.co/38oMlMr 

Former TPUSA insider Matthew Tucciarone goes nuclear in this must-watch podcast, ripping the lid off ballot harvesting fraud, massive data heists, and the deadly Zionist betrayal that led to Charlie Kirk's murder.

Turning Point USA and Erika Kirk are issuing cease and desist orders against people questioning the uncomfortable inconsistencies surrounding Charlie Kirk's assassination — no transparency, just intimidation. Instead of answering questions, they're trying to shut us down. Turning Point USA, under Erika Kirk's regime, is in meltdown—firing 30-40 insiders in a desperate hunt for the mole leaking info about shady embezzlements, Fort Huachuca plots, and the DOGE audit fallout. John Jubilee joins Stew to expose how Energized Health's inner cellular hydration protocol turned his dad bod into peak strength stronger than his 20s.

At the World Economic Forum in Davos, Jared Kushner presented plans for rebuilding Gaza as a luxury real estate hub — while tens of thousands lie dead and entire families remain buried under the rubble. This is what empire looks like in 2024: war, displacement, and then profit. Turning Point USA and Erika Kirk are issuing cease and desist orders against people questioning the uncomfortable inconsistencies surrounding Charlie Kirk's assassination — no transparency, just intimidation. Instead of answering questions, they're trying to shut us down.

Israel is at it again—staging false flags by dressing as Iranian protesters to gun down innocent kids with Israeli-made bullets, all exposed in child autopsies. Now Trump's flooding Iran with massive troops and weapons to spark WWIII and expand their empire. Stew joins Jimmy Rex on The Jimmy Rex Show for a raw look at the chaos hitting our streets and our screens. We're diving into the immigration crisis, the trap of foreign wars, and the systematic silencing of "unacceptable" opinions.

Turning Point USA, under Erika Kirk's regime, is in meltdown—firing 30-40 insiders in a desperate hunt for the mole leaking info about shady embezzlements, Fort Huachuca plots, and the DOGE audit fallout. Elon Musk's “free speech” X is a total fraud—Grok just blew the lid off 92% throttling that silences real patriots like Stew and Candace Owens while amplifying mouthpieces like Ben Shapiro to shove their anti-American agenda down our throats.  

EJ Prior joins Stew Peters to blow the lid off the Utah courtroom scam. Erika Kirk, now running TPUSA, is using her Epstein-tied lawyer Jeffrey Neiman (who defended Alex Acosta, the guy who gave Epstein his sweetheart plea deal) to frantically push for a speedy conviction of patsy Tyler Robinson.   Mitch Snow joins Stew to rip apart the TPUSA goons—Erika Kirk's Zionist attack dogs—who've been slinging personal smears to destroy the lone eyewitness to their Fort Huachuca hit on Charlie Kirk. But their DARVO tactics have exploded: every slanderer is now a subpoena target in Mitch's divorce case, forced under oath where lies mean perjury charges.  

Our children are being physically and mentally mutilated right in front of our eyes…shot after shot.    But one doctor is breaking his silence and EXPOSING it all.  

Minneapolis is imploding in flames YET AGAIN as ICE straight-up arms ruthless Somali invaders and violent communist gangs with pilfered federal guns—while barely deporting anyone amid the 50-MILLION alien swarm orchestrated by globalist elites! George Papadopoulos joins Stew to discuss the latest.   Larry Fink and BlackRock are forcing tokenization on everything you own—your house, your car, all of it—turning it into blockchain tokens they control so they can rip it away the second you step out of line. Carlos Cortez joins Stew to expose this World Economic Forum Mark of the Beast track-trace-control system.   Big Pharma has poisoned millions of Americans with deadly opioids and even everyday Tylenol, turning chronic pain sufferers into addicts or corpses. But Angie, a former world-class athlete turned health revolutionary, exposes the simple, drug-free secret to cleaning blocked joints and restoring your body—empowering you to break free from pain and take back your life starting today.

Top body language expert Bluemontauk dissects Mitch Snow's testimony, concluding he's spitting pure truth about spotting Erika Kirk slinking around Fort Huachuca just days before Charlie's brutal execution! Donald Trump is dragging America into a nightmare war with Iran, delivering the brutal regime change that bloodthirsty Israeli overlords and their bought-off DC scum have lusted after for decades! While the pedo elite bury the Epstein files deeper and assassinate truth-tellers like Charlie Kirk, they're placing aircraft carriers into position, looting oil fields, and gearing up to slaughter another wave of American youth on the altar of Greater Israel.

The Zionist-controlled puppets are shoving the ultimate scam down your throat—that Charlie Kirk's so-called “heartbroken widow” Erika is some wholesome all-American housewife—when she's a hardcore lifelong spook embedded with the CIA, crooked defense contractors, and sketchy Eastern European orphan mills. JD Sharp joins Stew with the latest. Trump's bogus “mass deportations” are just a flashy circus act to blind you from the nightmare truth—Zionist-controlled government thugs vanishing HUNDREDS OF THOUSANDS of migrant kids into twisted trafficking rings operated by their own corrupt NGOs!

Ruthless Israeli Unit 8200 thugs—the same bloodthirsty monsters behind Pegasus spyware and endless Palestinian slaughter—are now embedded deep in America's core, dominating over 70 US agencies through their shady Axonius front!  

High-glycemic index foods push your insulin and IGF-1 into ranges linked to lung cancer, raising risk across multiple tumor types, including small cell and adenocarcinoma High-glycemic load diets, when built from fiber-rich whole fruits, vegetables, and grains, showed a lower lung cancer risk because they produced steadier blood sugar responses rather than sharp spikes Both smokers and nonsmokers experienced significantly higher lung cancer odds when eating high-GI diets, showing that carbohydrate quality influences risk regardless of smoking history Fast-absorbing carbs and ultraprocessed foods often combine high-GI starches with high linoleic acid seed oils, creating an inflammatory, insulin-resistant environment that supports abnormal cell growth Simple dietary shifts — such as reducing ultraprocessed foods, choosing slower-digesting carbs, repairing your gut before increasing fiber, and stabilizing meal timing — help you lower metabolic patterns linked to lung cancer

847. Does a high-protein diet accelerate aging or shorten life expectancy? It's not a simple yes or no.ReferencesLow Protein Intake Is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population: Cell MetabolismNew Horizons: Dietary protein, ageing and the Okinawan ratio | Age and Ageing | Oxford AcademicDietary protein intake and all-cause mortality: results from The Kawasaki Aging and Wellbeing Project - PMCThe impact of dietary protein intake on longevity and metabolic health - PMChttps://pmc.ncbi.nlm.nih.gov/articles/PMC9269106/ New to Nutrition Diva? Check out our special Spotify playlist for a collection of the best episodes curated by our team and Monica herself! We've also curated some great playlists on specific episode topics including Staying Strong as We Age, Diabetes, Weight Loss That Lasts and Gut Health! Also, find a playlist of our bone health series, Stronger Bones at Every Age. Have a nutrition question? Send an email to nutrition@quickanddirtytips.com.Follow Nutrition Diva on Facebook and subscribe to the newsletter for more diet and nutrition tips. Find out about Monica's keynotes and other programs at WellnessWorksHere.comNutrition Diva is a part of the Quick and Dirty Tips podcast network. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

SHOCKING REVEAL: Sleazy Zionist mogul Ronald Lauder and his shadowy Jewish network have already sunk their claws into Greenland's precious water and economy—buying it all up like cheap real estate! Now Trump's gearing up for an all-out war against a loyal White NATO ally to lock in the takeover. This ice-cold theft? Zero for America—it's pure fuel for the emerging Jewish superstate, poised to dominate the entire Western Hemisphere and obliterate any nation dumb enough to challenge Tel Aviv's iron-fisted commands. Wake up before it's too late! BOMBSHELL COVER-UP: Utah Valley University, swarmed in with agents as guards, ripping into Charlie Kirk's fresh blood-soaked ground and slapping down pavers to obliterate every trace of the assassination before any honest probe could kick off. Big Pharma wants you fat, depressed, and hooked on toxic pills for profit. John Jubilee exposes the lie—real Americans are dropping 59lbs in 88 days, ditching 38 meds, and reversing "irreversible" diseases with Energized Health's protocol.  

Charlie Kirk's murder wasn't a chance—it was a calculated Zionist takedown of the last barrier to Jewish control of America, unleashing Venezuela invasions, Mexico wars, and rigged civil riots straight from Tel Aviv's playbook. With Kirk erased, scheming Israeli donors and their DC puppets sacrifice American blood for stolen oil and endless foreign schemes, prepping their jets to flee while we burn.  

Zionist vulture capitalist Paul Singer, Trump's mega-Jewish donor, just hijacked Citgo—the only U.S. heavy crude refinery—at dirt-cheap prices after Trump deliberately tanked its value through pirate ship seizures and brutal blockades. Now Trump is siphoning billions in stolen Venezuelan oil directly into Singer's coffers to bankroll Israel's endless wars and globalist schemes.   A white American mom of three was gunned down cold-blood by a faceless ICE agent in Minneapolis. Owen Shroyer teams with Stew to rip open this engineered psyop designed to unleash riots, crush freedoms, and force-feed the AI Gestapo down our throats. Is this the deep-state trigger for martial law? There is no law requiring Americans in the 50 states to file or pay federal income tax—yet trillions are seized to bomb nations for Jewish billionaires and push global degeneracy at gunpoint. Peymon Mottahedeh exposes the century-old fraud and gives you the exact, battle-tested steps to go exempt, keep your earnings, and join the millions already refusing to feed the swamp. Erika Kirk isn't just grieving—she's the centerpiece of a decades-long web connecting Romanian orphanages, U.S. military bases, and accusations of child trafficking that go straight to the top.  

Sheriff Mack joins Stew to dissect bombshell 2015 Phoenix Trump rally footage where Erika Kirk (Frantzve) sits right next to his own son, raising red flags on her shady ties, promiscuous vibes, and elite puppet strings. Sheriff Mack drops explosive truths with Stew—his direct talk with the Tyler Robinson case prosecutor's office reveals they were clueless about the assassination site's earth-deep dig-up and quick pave-over, erasing forensic evidence and splatter patterns forever.   Big Pharma's worst nightmare unleashed— they've suppressed the TZLA plasma tech for generations to keep you hooked on toxic drugs and killer injections, but Jeff Berwick rips the lid off this game-changer that vaporizes tumors, fixes stroke damage in hours, and cranks your energy to god-mode levels. Mainstream quacks like the FDA are scrambling to bury this, but the proof is exploding.

JD Sharp joins Stew to blow the lid off Trump's brutal betrayal—U.S. black ops just snatched President Maduro and his wife in a midnight raid, igniting an all-out war to crush one of the last holdout nations against the global elite. JD drops explosive details on how Venezuela's fierce fightback will drain American blood and treasure for the power brokers' agenda.   Description: Six years after the COVID death shots, turbo cancers are exploding, kids are dropping dead from myocarditis, and babies are born broken yet no doctor, nurse, or pharma exec has faced justice. Laura Hartman from Ezra Healing joins me to expose this protected genocide and revea   Charlie Kirk wasn't gunned down, his neck was ripped open by a concealed bomb in his lapel mic, detonated from afar to crush a voice challenging the Zionist power structure. John Bray joins Stew with game-changing evidence that proves the mechanics behind Charlie's fatal blow.  

Mitch Snow, Special Forces vet who spotted Erica Kirk at Fort Huachuca days before Charlie's assassination, is under savage attack by deep-state shills. Tonight he fires back, obliterates their lies, and proves their smears only drag the killers closer to justice. The quiet beach getaway turned into a spectacle when I went shirtless – ripped like a pro athlete because John & Chelsea Jubilee's Energized Health Protocol rebuilt me cell by cell with insane energy and clarity. Real fat loss and age reversal awaits,  grab the My 555 Challenge at My555Challenge.com for just $5 and lose 5 pounds in 5 days!

With the holidays in full swing and the New Year just around the corner, we're reflecting on all the great times we've had in 2025. Kick back and enjoy these highlights from the past year as we take a little winter break!

With the holidays in full swing and the New Year just around the corner, we're reflecting on all the great times we've had in 2025. Kick back and enjoy these highlights from the past year as we take a little winter break!

Investigative Journalist Kat Espinda joins Stew with receipts showing Mitch Snow is an innocent man.