Podcasts about hallmarks

In this solo episode of The SuperLife Podcast, Darin Olien dives deep into the true biology of energy—not motivation, not stimulants, not willpower, but the mitochondria themselves. Inspired by a groundbreaking conversation between Dr. Andrew Huberman and Dr. Martin Picard, Darin reframes energy as an emergent property of how we live, not just what we eat or how much we sleep. This episode explores how mitochondria act as signal translators, listening to your food, stress, sleep, movement, emotions, purpose, and environment—and turning those signals into either vitality or depletion. Darin connects cutting-edge mitochondrial science with real-world practices around recovery, meaningful stress, consistency, connection, and alignment, showing how true longevity and resilience are built at the cellular level.     What You'll Learn in This Episode 00:00  – Welcome to SuperLife & the mission of sovereignty and vitality 00:32 – Thera Sage sponsor: family-built healing tech & red light 02:10 – Why this episode is different: diving into cellular energy 02:42 – Inspiration from Huberman & Picard's mitochondria conversation 03:11 – Rethinking mitochondria: not just ATP, but information processors 04:03 – Energy as potential for change, not calories or fuel 04:39 – How thoughts, emotions, food, and stress shape energy 05:05 – Energy is dynamic, adaptive, and responsive to how you live 06:02 – Mitochondria as signal integrators: sleep, hormones, purpose, connection 06:50 – Mitochondria as antennas, not factories 07:16 – Translating life experience into biological energy 08:09 – Why we don't feel "energy," we feel energy flow 08:53 – Flow states, purpose, and why passion creates vitality 09:32 – Different organs, different mitochondrial roles 10:26 – Why energy optimization is not one-size-fits-all 10:49 – Energy resistance: the hidden cause of fatigue and burnout 11:47 – Chronic stress, poor sleep, and ultra-processed food as energy blockers 12:12 – Why recovery is non-negotiable for longevity 12:20 – Caldera Lab sponsor: clean, performance-driven skincare 14:20 – The danger of constant output without recovery 14:45 – Sleep as a mitochondrial reset and repair system 15:40 – Exercise, adaptation, and why recovery completes the signal 16:22 – Intentional stress vs. chronic stress 17:29 – Food as information, not just fuel 18:05 – Time-restricted eating, fresh food, and metabolic signaling 18:27 – Meaning, purpose, and emotional states as cellular inputs 19:23 – Mitochondria, aging, and the potential reversibility of decline 20:06 – SuperLife framework: alignment over optimization 20:37 – Consistency beats intensity at the cellular level 21:19 – Stable rhythms: sleep, nourishment, hydration, movement 21:45 – Stillness, meditation, and parasympathetic repair 22:35 – Growth requires both resistance and recovery 24:44 – Connection, community, and loneliness as biological signals 25:27 – Eliminating fatal conveniences to restore vitality 26:02 – Your mitochondria are listening—change the signals 26:21 – Honoring Huberman & Picard's contribution to human health 27:12 – Energy flow as the foundation of a SuperLife 28:11 – Closing reflections and invitation to apply this work     Thank You to Our Sponsors Therasage: Go to www.therasage.com and use code DARIN at checkout for 15% off Caldera Lab: Experience the clinically proven benefits of Caldera Lab's clean skincare regimen and enjoy 20% off your order by visiting calderalab.com/darin and using code DARIN at checkout.     Join the SuperLife Community Get Darin's deeper wellness breakdowns — beyond social media restrictions: Weekly voice notes Ingredient deep dives Wellness challenges Energy + consciousness tools Community accountability Extended episodes Join for $7.49/month → https://patreon.com/darinolien     Find More from Darin Olien: Instagram: @darinolien Podcast: SuperLife Podcast Website: superlife.com Book: Fatal Conveniences     Key Takeaway "Your mitochondria are not broken. They are responding perfectly to the signals you give them. Change the signals, and your energy, resilience, and life will follow."     Bibliography & Sources Here is the bibliography based on the sources referenced in the document, formatted with direct links to the scientific papers, books, and the podcast episode. Primary Source Material Huberman, A. (Host). (2025, December 15). Improve Energy & Longevity by Optimizing Mitochondria with Dr. Martin Picard [Audio/Video podcast]. Huberman Lab. Link to Episode Picard Lab. Mitochondrial Psychobiology Group. Columbia University Irving Medical Center. Link to Lab Website Key Scientific Literature & Books Hood, D. A., Memme, J. M., Oliveira, A. N., & Triolo, M. (2019). Exercise and Mitochondrial Biogenesis. Physiological Reviews, 99(1), 669–715. Read Study Lane, N. (2015). The Vital Question: Energy, Evolution, and the Origins of Complex Life. W.W. Norton & Company. Book Link López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013). The Hallmarks of Aging. Cell, 153(6), 1194–1217. Read Study Mattson, M. P., Moehl, K., Ghena, N., Schmaedick, M., & Cheng, A. (2018). Intermittent Metabolic Switching, Neuroplasticity and Brain Health. Nature Reviews Neuroscience, 19, 63–80. Read Study Picard, M., & McEwen, B. S. (2018). Psychological Stress and Mitochondria: A Systematic Review. Psychosomatic Medicine, 80(2), 126–140. Read Study Picard, M., & Shirihai, O. S. (2022). Mitochondrial Psychobiology: Foundations and Applications. Current Opinion in Behavioral Sciences, 43, 102–110. Read Study Speakman, J. R., & Selman, C. (2011). The Free-Radical Damage Theory: Accumulating Evidence Against a Simple Link. Trends in Ecology & Evolution, 26(1), 33–39. Read Study Wallace, D. C. (2015). Mitochondria and Cancer. Nature Reviews Cancer, 12, 685–698. (Note: Often referenced alongside his Annual Review of Genetics work on aging). Read Study

Most conversations about longevity focus on tactics. This episode breaks down the biology underneath them. You'll hear a systems level analysis of how insulin signaling, mTOR, mitochondrial function, inflammation, and nutrient sensing interact to determine biological age, disease risk, and long term human performance. This is not surface level biohacking. It is a deep dive into the mechanisms that actually control aging, metabolism, muscle preservation, and brain optimization, and why most anti aging strategies fail when they ignore these foundations. This all-time classic episode from 2024, has host Dave Asprey joined by Mark Hyman, a practicing physician and one of the most respected leaders in functional medicine. Dr. Hyman is the founder and senior advisor of The UltraWellnessCenter, the founder and former head of strategy and innovation at the Cleveland Clinic Center for Functional Medicine, and a long time advocate for treating root causes instead of managing disease. With over 30 years of clinical experience, his work focuses on restoring mitochondrial health, optimizing metabolism, reversing chronic disease, and slowing biological aging using science backed interventions. Together, Dave and Mark dismantle common myths around protein, carnivore diets, ketosis, fasting, supplements, and longevity drugs. They explain why sugar accelerates aging faster than protein, how mTOR must cycle instead of staying suppressed, and why muscle, mitochondria, and metabolic flexibility matter more than calorie restriction. The conversation also covers nootropics, sleep optimization, neuroplasticity, AI driven diagnostics, and how functional medicine reframes aging as a reversible biological process rather than an inevitable decline. You'll learn: • How insulin and nutrient sensing control aging speed • Why mitochondria sit at the center of longevity and disease • The truth about mTOR, fasting, and protein intake • How ketosis and metabolic flexibility protect long term health • Where supplements and nootropics actually fit in brain optimization • Why functional medicine outperforms symptom based care • How AI and advanced testing are reshaping modern medicine Thank you to our sponsors! - MASA Chips | Go to https://www.masachips.com/DAVEASPREY and use code DAVEASPREY for 25% off your first order. -ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order. -OneSkin | Try OneSkin for 15% off with code DAVE at https://www.oneskin.co/DAVE. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: longevity biohacking, functional medicine longevity, biological age reversal, mitochondria and aging, mTOR pathway aging, insulin resistance and aging, metabolic flexibility, fasting and longevity, ketosis and metabolism, protein intake and mTOR, muscle and longevity, inflammaging, chronic inflammation aging, mitochondrial dysfunction, nutrient sensing pathways, rapamycin longevity, metformin longevity debate, carnivore diet longevity, sugar and aging, brain optimization longevity, neuroplasticity and aging, sleep optimization biohacking, supplements for longevity, anti aging metabolism, human performance optimization, Dave Asprey longevity, Mark Hyman longevity Resources: • Mark's Website: https://drhyman.com/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 - Trailer 0:45 - Introduction 4:49 - Aging as a Treatable Disease 7:50 - The Hallmarks of Aging 14:23 - Nutrient Sensing and Longevity Switches 17:37 - Time Restricted Eating and Autophagy 20:44 - The Four Longevity Pathways 21:49 - Metformin Debate 25:30 - Ozempic and Weight Loss 28:42 - Rapamycin and mTOR 36:23 - Meat, Protein, and Aging 39:46 - Protein Quality and Muscle Synthesis 45:50 - Protein Timing for Muscle Building 48:08 - Metabolic Flexibility 51:32 - Inflammaging 55:26 - Zombie Cells and Senescence See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this episode of Skin Anarchy, Dr. Ekta Yadav sits down with Smitha Rao—biotechnologist, longtime beauty innovator, and founder of Pareva Beauty—for a grounded, science-first conversation on what skin longevity actually means. Part of the Lessons in Longevity series, this episode challenges the tired idea of “anti-aging” and reframes skincare as long-term biological support rather than surface-level correction.With nearly two decades in biotech and beauty, Smitha brings a rare perspective shaped by molecule development, patents licensed across major brands, and leadership roles behind more than 200 products. That experience revealed a growing disconnect: while consumers want clarity and real science, the industry often defaults to hype, fear-based claims, and trend chasing. Pareva Beauty was born as a response—built on transparency, rigor, and the belief that longevity is about extending skin function and resilience, not reversing time.At the center of the discussion is Molecur 3™, Pareva's proprietary, plant-based technology inspired by the Hallmarks of Aging. Smitha explains how targeting inflammation, cellular stress, and age-related decline—rather than isolated “anti-aging” claims—creates a more realistic and sustainable path for skin health. The conversation also dives into plant-derived exosomal signaling, why it differs from human-derived systems, and how it offers a safer, scalable approach for topical longevity skincare.Together, Dr. Ekta and Smitha unpack why fewer, better-designed products outperform complex routines, why transparency matters more than vague “clean” labels, and how longevity skincare must earn trust through data—not promises.Listen to the full episode to hear how Smitha Rao is helping redefine the future of skincare—where science, honesty, and long-term skin health come first.Shop Parëva Beauty and use code SA20 for 20% through 3/17.CHAPTERS:(0:02) - Introduction, Lessons in Longevity & Smitha Rao(1:21) - From Biotech to Beauty Innovation(2:50) - Why Pareva Was Created & The Longevity Gap(3:33) - Defining Skin Longevity & Extending Your Prime(5:38) - Rejecting Anti-Aging & Reframing Aging Quality(8:51) - Molecure 3™: Hallmarks of Aging Inspiration(10:27) - Plant Stem Cells, NAD⁺ & Exosome Signaling(14:00) - Exosomes Explained: Plant vs Human-Derived(22:51) - Simplifying Skincare: Fewer Steps, Better ResultsPlease fill out this survey to give us feedback on the show!Don't forget to subscribe to Skin Anarchy on Apple Podcasts, Spotify, or your preferred platform.Reach out to us through email with any questions.Sign up for our newsletter!Shop all our episodes and products mentioned through our ShopMy Shelf!*This is a paid collaboration Hosted on Acast. See acast.com/privacy for more information.

In this episode of "Women of Impact," Lisa Bilyeu welcomes Dr. Orion Taraban, psychologist, YouTube creator, and author of the bestselling book "The Value of Others." Dr. Taraban brings a refreshingly candid — and sometimes controversial — perspective to the complex world of romantic relationships, power dynamics, and emotional safety. Together, they pull back the curtain on common traps women fall into, how to recognize manipulation (especially from narcissists or cluster B personalities), and the essential mindsets needed to reclaim your relationship power once and for all. Dr. Taraban and Lisa set the groundwork by tackling why no one can technically manipulate your emotions — unless you allow them to. This is essential listening for anyone looking to understand how to protect themselves while dating—or simply elevate their personal relationships to a new level of autonomy. In this episode: The Nature of Manipulation & Emotional Vulnerability Why “Poker Face” Tactics Matter for Safety Real-World Examples: DARVO & the Anatomy of Gaslighting The 10 Principles of Power: Who Really Holds the Cards? Women, Power, and the Unspoken Rules of Pursuit The Role of Optionality in Relationships Double Standards, Gendered Power, and Inequality Attraction, Fantasy, and the Dangers of Projecting Red Flags, Rationalizations & Why We Stay Cluster B Personalities and the Hallmarks of Narcissistic Abuse Thank you to our sponsors:  Macy's: Upgrade your glam at https://macys.com Vital Proteins: Get 20% off by going to https://www.vitalproteins.com and entering promo code WOI at check out. Found: Open a Found account for FREE at http://found.com True Classic: Discounts at https://trueclassic.com/WOI OneSkin: 15% off code LISA at https://oneskin.co Shopify: Sign up for your one-dollar-per-month trial period at https://shopify.com/lisa Magic Spoon: code LISABILYEU $5 off https://magicspoon.com/lisabilyeu Follow Dr. Orion Taraban: YouTube: https://www.youtube.com/@psychacks Website: https://oriontarabanpsyd.com/ FOLLOW LISA BILYEU: Instagram: ⁠https://www.instagram.com/lisabilyeu/⁠ YouTube: ⁠https://www.youtube.com/womenofimpact⁠ Tik Tok: ⁠https://www.tiktok.com/@lisa_bilyeu?lang=en Facebook: https://www.facebook.com/lisabilyeu Learn more about your ad choices. Visit megaphone.fm/adchoices

In this conversation, I cover the emerging science on psychedelics. Not the hype, but the data.How these compounds interact with the brain, reopen windows of neuroplasticity, and appear to influence aging, neurodegenerative disease, mental health, trauma, and resilience in ways we're only beginning to understand.I walk through studies looking at psychedelics in neurodegenerative disease, stroke recovery, and end-of-life care, specifically improvements in Parkinson's, life extension in cells and mice, and cancer patients losing their fear of death.The thread tying all of this together is simple but uncomfortable: longevity isn't just about adding years to the body. It's about tending to the nervous system, the mind, and the stories we carry.If we want to live longer and better, we may need to stop treating biology and psychology as separate systems, and start designing a more integrated, humane approach to aging.Timestamps:00:00 Introduction to Epigenetics and Longevity02:42 The Intersection of Psychedelics and Longevity05:36 Understanding the Hallmarks of Aging08:51 Mental Health, Neuroplasticity, and Aging11:45 Psychedelics and Neurodegenerative Diseases14:46 Psychedelics in Stroke Recovery17:33 Psychedelics and Trauma Healing20:30 Psychedelics in End-of-Life Care23:41 The Future of Longevity and PsychedelicsCONNECT WITH NINA'S NOTESNewsletter: https://www.ninasnotes.xyzLinkedIn: https://www.linkedin.com/in/ninapatrick/Website: https://www.ninapatrick.xyz Get full access to Nina's Notes at www.ninasnotes.xyz/subscribe

It's time to talk about some more news and movies within Hallmark Channel land. Christmas Cup and Catnip Cafe review with Hallmarks:  https://youtu.be/smCkwzkZL4Y?si=mtxi0yzR_zYO1IeHLacey's 2026 Disney Christmas Movie article: https://variety.com/2025/tv/news/hallmark-disney-world-christmas-movie-lacey-chabert-1236601875/Say hello: dearhallmark@gmail.com Youtube:https://youtube.com/@dearhallmark?si=o_vx3T2kEjMoqK7YTo purchase "Chasing Wind": https://amzn.to/3IGUI6gDear Hallmark's Instagram: https://www.instagram.com/dearhallmark/Christmas Wonderland Playlist: https://open.spotify.com/playlist/0X9MKYdAnZ1l2sxN1xjsvc?si=df28ee7b6575457b

This episode is sponsored by Flipping 50 Menopause Fitness Specialist. Become a health & fitness coach who finally speaks midlife women's language. Learn how to design workouts that balance hormones that actually get results for women in menopause. Other Episodes You Might Like: Previous Episode - Thyroid Health Next Episode - What's Still Missing from Women's Fitness Programs More Like This: What They Don't Teach Trainers About Exercise Prescription The ONE Thing Your Menopause Fitness Routine Is Missing Effects of Menopause Exercise on 12 Hallmarks of Aging Resources: Join Flipping 50 Menopause Fitness Specialist® to become a coach! Don't know where to start? Book your Discovery Call with Debra. Leave this session with insight into exactly what to do right now to make small changes, smart decisions about your exercise time and energy. Get the Exercise RX for Women Over 40 and master the programming variables that make or break results for women in midlife! Use Flipping 50 Scorecard & Guide to measure what matters with an easy at-home self-assessment test you can do in minutes. Women's fitness programs don't always tell the truth about what really works in menopause—and that's exactly why this episode matters.  If you've been working out harder, longer, or “like you used to” and still not seeing results, consider this your turning point.  Midlife fitness isn't about doing more—it's about doing what actually works with your hormones, your energy, and your real life.  Let's talk about how the right women's fitness programs can finally help you feel stronger, sleep deeper, tone faster, and love your workouts again.

Other Episodes You Might Like: Previous Episode - The Perimenopause Brain Health Window with Mariza Snyder Next Episode - Thyroid Health with McCall McPherson More Like This: Exercise Recovery After 40: Connective Tissue in Menopause Effects of Menopause Exercise on 12 Hallmarks of Aging 5 Things I Do When I Need a Reset or I've Had a Fitness Plateau Resources: Get the Flipping 50 STRONGER 12-week program for your at-home safe, sane, simple exercises. Join Flipping 50 Menopause Fitness Specialist® to become a coach! Don't know where to start? Book your Discovery Call with Debra. Leave this session with insight into exactly what to do right now to make small changes, smart decisions about your exercise time and energy. If you've been doing all the right things but still not seeing the results you deserve, this episode will show you exactly what your menopause fitness routine is missing. You're eating right, lifting weights, walking, and following all the “they say” advice — yet your metabolism, muscle tone, or energy still feels stuck. Today, I'm revealing the one game-changing ingredient most midlife women overlook. No… it's not another supplement, diet tweak, or fancy fitness app. You'll hear why your workouts may be quietly working against you. You'll understand why your menopause fitness routine is missing this essential piece — and how adding it back brings your energy, metabolism, and confidence roaring back.

If you're interested in optimising your healthspan and lifespan, this episode is not to be missed. In the quest for longevity, the spotlight has turned to NAD+ and its precursors, NMN and NR. In this episode featuring Dr. Charles Brenner, a metabolism scientist, we dive deep into the significance of these molecules and their role in healthy aging. You'll discover that NAD+ (Nicotinamide Adenine Dinucleotide) is not just a trending topic but rather a crucial player in metabolism. Learn why Charles refers to it as the "central jewel of metabolism". In the conversation, the distinction between NMN (Nicotinamide Mononucleotide) and NR (Nicotinamide Riboside) is clarified, and you'll discover which of these molecules has the best evidence-base. You'll also find out why some popular ways to increase NAD+ are an expensive waste of time. Dr. Brenner highlights the importance of evidence-based research, citing eight randomised clinical trials demonstrating the anti-inflammatory effects of one of the NAD+ precursors in humans. One significant study focuses on peripheral artery disease (PAD), a condition affecting millions of older adults that can severely impact mobility and quality of life. Ypu'll also disciver why a simple functional test is a way better predictor of longevity than all of the espoensive epigenetic-focused Biological Age tests that are currently on the market. What You'll Learn: The Basics of NAD and Its Functions: Understand the foundational role of NAD in cellular metabolism and how it acts as a transmitter of high-energy electrons needed for energy production and cell functions. Scientific Evidence and Research: Discover the rigor behind the clinical research of NAD and its supplements, like Nicotinamide Riboside (NR), including ongoing trials and results showing anti-inflammatory properties in humans. Controversies and Misconceptions: Unpack the myths concerning longevity molecules, such as misinterpretations around resveratrol, with arguments laid out by reputable scientists like Dr. Brenner. Applications in Age-Related Diseases: Explore the potential of NR supplements in addressing conditions like peripheral artery disease and its promising though variable outcomes in treating Long COVID and neurodegenerative diseases. Critical Analysis of Clinical Trials: Learn about the importance of clinical integrity, unbiased research, and how independent laboratories contribute to credible scientific discoveries. Key Takeaways: NAD is vital for maintaining metabolic health and managing cellular stress, which is essential for healthy aging. Recent clinical trials have shown promising results for NR in reducing inflammation and improving conditions related to peripheral artery disease. There's ongoing research into NR's benefits for cognitive function, particularly its potential effects on neurodegenerative disease. Supplements should be chosen carefully, preferably ones that have been tested in clinical trials to ensure efficacy and authenticity. The conversation between Dr. Taylor and Dr. Brenner highlights the need to critically evaluate scientific claims, especially those that are widely publicised without robust evidence. Through the episode, Dr. Brenner provides deep insights into how NAD coenzymes operate within the body and why they're considered crucial for longevity research. Moreover, listeners are encouraged to discern meticulously between scientific fact and internet hype, ensuring they make informed decisions when considering supplements. The episode is a valuable resource for anyone interested in the intersection of biochemistry, aging, and healthspan science. Resources Socials: X: @CharlesMBrenner LinkedIn: https://www.linkedin.com/in/charles-brenner/ Support the Podcast If you found this conversation valuable, consider subscribing and leaving a review on your preferred podcast platform. Your feedback helps us continue to bring you insightful discussions on important health topics. 00:11 Understanding NAD+ and Longevity Molecules 01:31 Debunking Longevity Myths 03:02 The Science Behind NAD+ and Metabolism 08:46 Clinical Trials and Evidence 09:37 Peripheral Artery Disease and NAD+ 11:00 Walking Speed as a Health Indicator 13:25 Challenges with DNA Methylation Clocks 21:40 NAD+ in Metabolic Processes 23:48 The Role of NAD in DNA Repair and Cellular Health 24:09 Inflammation and Aging: The Connection 25:20 Human Longevity and Reproductive Capacity 30:02 The Hallmarks of Aging 31:11 Challenges of Living in 2025: Long COVID 31:42 Clinical Trials and NAD Supplements 34:33 The Debate on NMN vs. NR 41:58 Intravenous NAD and Its Efficacy 45:06 NAD's Role in Neurodegenerative Diseases See omnystudio.com/listener for privacy information.

A jovial Drake Maye joins, talks win over the NYJ, mini bye and the hallmarks of playing multiple sports

Today, Jakub Remiar breaks down the Scopely-style “sticker album” collectible mechanic—popularized at scale by Monopoly Go (global April 2023)—and why it's sweeping casual and now encroaching on mid-core. Hallmarks: time-limited albums, gacha booster packs, duplicate sinks → premium packs, and peer trading that drives massive social engagement (e.g., official trading groups). It adds perceived depth to shallow economies (soft currency + energy) without adding gameplay complexity, resets cleanly by season, and monetizes whales via “double bottom” albums (a second, higher-reward album with ~50% more rewards and exclusive cosmetics). Implementations span Royal Match (135 cards/≈60 days), Travel Town (162), Monopoly Go (~200), and mid-core experiments like Whiteout Survival and Acecraft (smaller sets, licensed collabs). The open questions: optimal card counts, season length, and how mid-core will standardize the pattern. What you'll learnHow the Scopely/Monopoly Go sticker album works: time-limited albums, gacha packs, duplicate exchanges, trading, seasonal resets, and whale “double albums.”Why this mechanic adds depth to shallow economies and boosts engagement, retention, and monetization—with examples from Royal Match, Travel Town, Monopoly Go and mid-core tests (Whiteout Survival, Acecraft).Practical knobs: card counts (≈135–200), season length (30–60 days), guaranteed-missing pack, and social/trading ops.Get our MERCH NOW: 25gamers.com/shop--------------------------------------PVX Partners offers non-dilutive funding for game developers.Go to: https://pvxpartners.com/They can help you access the most effective form of growth capital once you have the metrics to back it.- Scale fast- Keep your shares- Drawdown only as needed- Have PvX take downside risk alongside you+ Work with a team entirely made up of ex-gaming operators and investorsJoin our slack channel here: https://join.slack.com/t/two-and-half-gamers/shared_invite/zt-2um8eguhf-c~H9idcxM271mnPzdWbipgChapters00:00 — Cold open & why albums exploded01:20 — The template: pages, rarities, grand prize, timebox03:45 — Rewards & pressure: limited window, page bonuses, grand prize06:10 — Gacha everywhere: pack sources & duplicate sink design08:30 — Social engine: trading loops (in-clan & community)10:20 — Seasonal resets & cosmetics: depth without UX bloat12:10 — “Double/Grand Album” for whales (~50% more rewards)14:00 — Case studies: Monopoly GO, Royal Match, Travel Town17:00 — Mid-core spillover: Whiteout Survival, Acecraft experiments19:00 — Tuning knobs: card counts (≈135–200), 30–60 day seasons, guarantees20:30 — Actionable checklist & pitfalls---------------------------------------Matej LancaricUser Acquisition & Creatives Consultant⁠https://lancaric.meFelix BrabergAd monetization consultant⁠https://www.felixbraberg.comJakub RemiarGame design consultant⁠https://www.linkedin.com/in/jakubremiar---------------------------------------Please share the podcast with your industry friends, dogs & cats. Especially cats! They love it!Hit the Subscribe button on YouTube, Spotify, and Apple!Please share feedback and comments - matej@lancaric.me---------------------------------------If you are interested in getting UA tips every week on Monday, visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠lancaric.substack.com⁠⁠⁠⁠⁠⁠ & sign up for the Brutally Honest newsletter by Matej LancaricDo you have UA questions nobody can answer? Ask ⁠⁠⁠⁠⁠⁠⁠⁠Matej AI⁠⁠⁠⁠⁠⁠ - the First UA AI in the gaming industry! https://lancaric.me/matej-ai

In this episode of the Flex Diet Podcast, I sit down with my good friend Dr. Dan Pardi for a deep dive into all things health, longevity, and cognitive performance. We get into the science of stem cells and aging, the real benefits (and limits) of popular supplements, and how nootropics like Ritalin and Modafinil actually work—or don't—in the real world.We also talk about how to integrate training and movement into insanely busy lives, the psychology of health behavior, and why being flexible in your approach (not just in your hamstrings) is key to long-term success.This episode is brought to you by Quaia Life, where Dan's doing some fascinating work on cutting-edge supplements designed to optimize health and performance. They're offering listeners 15% off their products, which you can grab through the link in the show notes.If you want a mix of actionable tips, science-backed insights, and a peek behind the curtain of how top researchers think about performance and aging, you'll definitely want to tune in.Sponsors:Daily Fitness Insider Newsletter: https://flex-diet.kit.com/bfa1510fa8Qualia: https://qualialife.com/drmike15Coupon Code: DRMIKE15 (listeners get an additional 15% off any Qualia order)Available now:Grab a copy of the Triphasic Training II book I co-wrote with Cal Deitz here.Episode Chapters:01:51 Science Communication and Cognitive Performance02:43 Sponsorship and Product Endorsement04:54 The Importance of Flexibility in Training06:39 Integrative and Opportunistic Training15:50 The Psychology of Health and Performance24:12 Quality of Life and Nootropics31:12 Understanding Cognitive Enhancement44:30 Modafinil and Its Effects50:50 Exploring the Benefits and Downsides of a New Drug51:22 Mechanisms and Effects of the Drug52:42 Hallmarks of Aging and Their Impact58:07 Understanding Stem Cells and Their Functions01:01:52 Formulating a Stem Cell Supplement01:10:18 Sequencing Protocols for Optimal Health01:15:13 Challenges and Research in the Supplement Industry01:23:33 Final Thoughts and Recommendations01:34:29 Podcast Conclusion and Disclaimers Flex Diet Podcasts You May Enjoy: Episode 263: Lifestyle, Longevity, and the Future of GLP-1 Agonist Use in Wellness with Christa RymalYouTube: https://youtu.be/SlALIb74KvMEpisode 165: Health, Sports Performance and Longevity Medicine: Dr Rick Cohen with Dr. Mike T NelsonYouTube: https://youtu.be/bYk_wzBJzJYConnect with Dr Pardi:Qualia: https://www.qualialife.com/Instagram: https://www.instagram.com/dan_pardiGet In Touch with Dr Mike:Instagram: DrmiketnelsonYouTube: @flexdietcertEmail: Miketnelson.com/contact-us

This episode is sponsored by BIOptimizers. BIOptimizers Magnesium Breakthrough contains an optimal ratio of all 7 types of Magnesium, formulated for maximum absorption. Get a 15% discount by using promo code Flipping50 at checkout. Other Episodes You Might Like: Previous Episode - Effects of Menopause Exercise on 12 Hallmarks of Aging Next Episode - How Healthy Skin Contributes to Healthy Aging More Like This - The Exercise Crisis Destroying Women's Metabolisms (And How to Fix It with Just 2 Workouts) Resources: Join the Hot, Not Bothered! Challenge to learn why timing matters and why what works for others is not working for you. Use Flipping 50 Scorecard & Guide to measure what matters with easy at-home self-assessment test you can do in minutes. Don't know where to start? Book your Discovery Call with Debra. Leave this session with insight into exactly what to do right now to make small changes, smart decisions about your exercise time and energy. Existential Kink: Unmask Your Shadow and Embrace Your Power Thrive in your midlife despite the menopause metabolic shift no one is talking about. In this episode, we're going beyond how “hormones affect metabolism” to uncover the cellular cascade most practitioners miss.  Ever wonder why resistance training suddenly stops working, why your chronic cardio habit might be sabotaging results, or how overtraining is leaving you exhausted? My guest brings the research—and the real science—behind peptides versus the marketing hype. If you're ready to flip the switch on the menopause metabolic shift, you'll love what this episode reveals about your true strength, energy, and power in midlife. My Guest: Dr. Melissa Grill-Petersen, DC, MS, BCHH is a chiropractor, longevity researcher, and co-founder of Peptide University—where she educates clinicians worldwide on cutting-edge peptide and regenerative medicine. She's the creator of the BioHealthSpan Model, a TEDx speaker, and best-selling author of The Codes of Longevity. For over 25 years, she's been translating longevity science into protocols that help us live not just longer, but better. Questions We Answer in This Episode: [00:07:18] What's the most surprising thing about women's metabolic response in perimenopause—and what does it teach us about when to intervene? [00:13:07] How does mindset act as a “longevity molecule,” and can changing how we think about aging actually shift biological markers like HRV and inflammation? [00:21:05] What's really happening when overtraining backfires, HRV tanks, and fatigue sets in—and how can you fix it without just “doing less”? [00:33:39] For women who've stopped moving, what's the minimum effective dose of exercise to restart metabolic signaling—and does walking really make a difference? [00:37:55] Why can “doing everything right” still fail—what causes resistance training to stop working in midlife?  [00:41:47] What's the biggest mistake practitioners make when trying to “fix” a woman's metabolism in midlife?

Jen Psaki observes that as Donald Trump gets more comfortable with his autocrat persona, the traits that made him a societal laughing stock all his life are coming to define his leadership style. And the mockery he has become has so diminished him that his opponents are emboldened to get in the way of his demolition of the United States.Donald Trump's lackeys in Congress are trying to support his effort to exact revenge on the public servants who tried to hold him to account. Former special counsel Jack Smith is a prominent name on Trump's enemies list, so it's not surprising that Congressional Republicans would try to discredit him with their investigating-the-investigators hearings. Former federal prosecutor Andrew Weissmann talks with Jen Psaki about why Jack Smith is smart to agree to participate in the hearings on the condition that they be public.  Jen Psaki addresses questions posed at the White House press briefing, giving more honest and direct answers than the White House is willing to offer on questions ranging from Donald Trump's desecration of the White House to Trump's pardoning of a crypto-criminal business associate.  Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

This episode is sponsored by AirDoctor and HERS. AirDoctor purifies your home's air quality by capturing microscopic particles and eliminates 99.55% tested viruses and bacteria. Get $300 off by using promo code Flipping50 at checkout. HERS connects you with licensed healthcare professionals who create personalized treatment plans for your weight loss, hair growth, mental health, and skincare needs. Visit forhers.com/flipping to get your personalized treatment plan. Other Episodes You Might Like: Previous Episode - Scared of Estrogen? Listen to this Dr with Breast Cancer Survivor Next Episode - The Menopause Metabolic Shift No One's Talking About More Like This - Aging with Power, (Without an Outage) with Vonda Wright Resources for the 12 Hallmarks of Aging: Join the Hot, Not Bothered! Challenge to learn why timing matters and why what works for others is not working for you. Don't know where to start? Book your Discovery Call with Debra. Leave this session with insight into exactly what to do right now to make small changes, smart decisions about your exercise time and energy. Use Flipping 50 Scorecard & Guide to measure what matters with an easy at-home self-assessment test you can do in minutes. BIOptimizers Magnesium Breakthrough contains an optimal ratio of all 7 types of Magnesium, formulated for maximum absorption. Get a 15% discount by using promo code Flipping50 at checkout. OneSkin OS-01 is the first peptide scientifically proven to reduce cellular senescence in the skin, causing wrinkles, hyperpigmentation, and crepiness. Get a 15% discount on your first purchase by using promo code Flipping50 at checkout. Mitopure is a direct source of urolithin A, which can boost mitochondrial function, and is linked to improved DNA repair pathways. Get a 20% discount by using promo code Flipping50 at checkout. Ever wonder what the 12 hallmarks of aging really mean for you — especially in midlife? What if you could slow down — or even reverse — aging with the right exercise and habits? In this episode, I'm breaking down the science of aging and show you exactly how exercise during menopause can help reverse, slow, or even flip those hallmarks of aging. This is your 12 Hallmarks of Aging cheat sheet to age better, not just longer — and yes, it's 100% doable.

Other Episodes You Might Like: Previous Episode - Finding Exercise Motivation After Menopause Next Episode - Effects of Menopause Exercise on 12 Hallmarks of Aging More Like This - Sexy Brain: Sizzling Intimacy and Balanced Hormones: Dr Lindsey Berkson Resources: Join the Hot, Not Bothered! Challenge to learn why timing matters and why what works for others is not working for you. Don't know where to start? Book your Discovery Call with Debra. Leave this session with insight into exactly what to do right now to make small changes, smart decisions about your exercise time and energy. Dr. Berkson's eGuides: Estrogen Vindication, Hormones for Breast Cancer Survivors Dr. Berkson's newest book due out in September 2025 This episode is sponsored by AquaTru and BIOptimizers. AquaTru removes what most filters miss, including forever chemicals, microplastics, lead, and more. They use 4-stage reverse osmosis technology with most customers saying it's the best tasting water they've had. Get a 20% discount by using promo code Flipping50 at checkout. BIOptimizers Magnesium Breakthrough contains an optimal ratio of all 7 types of Magnesium, formulated for maximum absorption. Get a 15% discount by using promo code Flipping50 at checkout. Scared of estrogen? Confused about estrogen? It's not your fault.  If you want a beautiful idea of what the late 70s could look like, if you want evidence breast cancer survivors can thrive better and stop being scared of estrogen, you'll hear it here.  My Guest: Dr. Devaki Lindsey Berkson is a leader in functional medicine with emphasis on hormones, the environment, cancer and the gut. She is the GOAT in this space at 76 she is going strong in spite of multiple bouts of cancer due to balanced hormones from compounding pharmacists.  Dr. Berkson is a DES daughter and often shares how her life has been "ruined" and "saved" by hormones. Secondary to DES, she had breast cancer 30 years ago, kidney cancer 20 years ago and has been on BHRT and 2 MEO for decades now. Questions We Answer in This Episode: [00:03:24] How do you approach your aging?  [00:18:38] After cancer yet on hormones, tell us that journey? [00:26:53] Why is estrogen still feared? [00:40:38] What's your hope for hormone advice and support will turn around? [00:49:33] What do you want to tell women who are considering or still are second guessing information about hormones?

In this episode, Dr. Jockers sits down with longevity expert Dr. Isaac Jones to explore how oxidative stress accelerates aging—and what you can do to slow it down. Learn how mitochondrial health determines your energy, focus, and vitality, and why small daily habits have a massive impact on how you age.   You'll also discover the “hallmarks of aging” and how lifestyle choices like diet, sleep, and mindset influence everything from inflammation to cellular repair. Dr. Jones shares the science behind epigenetics and how your environment and behavior can literally switch your longevity genes on or off.   Finally, dive into cutting-edge nutrition insights and longevity stacks designed to extend both your lifespan and healthspan. From mitochondrial boosters to antioxidant powerhouses, Dr. Jockers and Dr. Jones break down the nutrients and strategies that keep your brain sharp and your energy high well into later life. In This Episode: 00:00 Understanding Oxidative Stress and Aging 02:34 Exploring Longevity and Aging 03:20 Meet Dr. Isaac Jones: Longevity Expert 04:16 Breakthrough Nutrients for Longevity 06:20 The Role of Epigenetics in Aging 08:12 Hallmarks of Aging and Their Impact 12:50 The Importance of Mitochondrial Health 18:57 Key Nutrients for Longevity 24:20 Maintaining Muscle Mass for Longevity 24:58 The Role of Gut Microbiome in Health 26:00 The Power of Pomegranate Extract 28:59 The Importance of Glutathione 30:29 Understanding PFAS and Their Impact 32:34 Creating a Synergistic Longevity Stack 39:36 Innovative Supplement Delivery System 44:23 Customizing Supplements for Individual Needs 45:37 Conclusion and Final Thoughts If you want a nutrient-packed boost, check out Paleo Valley's Grass-Fed Organ Complex—a supercharged multivitamin containing liver, heart, and kidney from healthy pasture-raised cows. It delivers a full spectrum of B vitamins, minerals, amino acids, and peptides without the strong taste of organ meat. For a 15% discount, visit paleovalley.com/jockers and stock up on this powerful supplement to support energy, mental clarity, and overall health. Looking to boost your digestion, immunity, and energy? Just Thrive Probiotic is the answer! Unlike most probiotics that get destroyed by stomach acid, Just Thrive is clinically proven to reach your gut 100% alive. This means better digestion, improved immunity, enhanced energy, and easier weight management. Plus, with their industry-leading 100% money-back guarantee, you've got nothing to lose. Save 20% off your order with code JOCKERS at justthrivehealth.com.   "Oxidative stress is like internal rusting—it's the silent culprit behind aging, but we have the tools to combat it."   Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean  TuneIn Radio   Resources: Get 15% off Paleovalley: paleovalley.com/jockers – Use code JOCKERS Save 20% on Just Thrive: justthrivehealth.com – Use code JOCKERS   Connect with Dr. Isaac Jones: http://www.fullyvital.com/ Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https:/www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/ If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/

Build a more functional family today. In this episode, Whitney breaks down the hallmarks of functional families, how these skills can be learned regardless of how you grew up, and practical steps to get started. Whitney Goodman is a Licensed Marriage and Family Therapist (LMFT) and the founder of Calling Home, a membership community that helps people navigate complex family dynamics and break harmful cycles. 00:00 Introduction: What Functional Families Actually Look Like 02:31 Admitting When There Are Problems 03:51 Open Communication and Repair 04:37 Being Known Without Performance 05:17 Reliability and Dependability 05:57 Zero Abuse or Neglect 07:21 Unconditional Belonging 09:14 Small Actions You Can Start Today Whitney Goodman is a Licensed Marriage and Family Therapist (LMFT) and the founder of Calling Home, a membership community that helps people navigate complex family dynamics and break harmful cycles. Have a question for Whitney? Call in and leave a voicemail for the show at 866-225-5466 Join the Family Cyclebreakers Club⁠⁠ Follow Whitney on Instagram | sitwithwhit Follow Whitney on YouTube | @whitneygoodmanlmft ⁠⁠Order Whitney's book, Toxic Positivity⁠⁠ Learn more about ad choices. Visit podcast.choices.com/adchoices This podcast is for informational purposes only and is not a substitute for professional mental health advice. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Stuart Wachowicz - TVCA1410 - Church buildings come in all shapes and sizes. Some are very small, humble structures, while others are massive, elaborate edifices which required years to build. Yet, even more varied than the size and architecture of their facades are the customs, ways of worship, and beliefs that they represent. Why? If all identify as Christian and supposedly have a common text, the Bible, as their foundational text. Which of these churches would the original apostles attend if they were alive today? Do these churches all represent the original doctrines of the Church? They cannot all be correct.

Puccini's operas remain some of the most beloved in the repertoire, their soaring melodies and emotional intensity instantly recognisable to audiences worldwide.From the romance and tragedy of La Bohème, to the raw passion of Tosca and the exotic splendour of Turandot, Puccini created worlds of intense drama and unforgettable melody.In this episode we are joined by musician and broadcaster Sandy Burnett as he explores what makes Puccini's music so distinctive and enduring. With insights from musical experts, Sandy uncovers the orchestral colours, vocal writing and dramatic instincts that defined Puccini's genius.Academy Travel is a leading specialist in small-group cultural tours, allowing you to travel with like-minded companions and learn from internationally renowned experts. Like our podcast, our tours are designed to appeal to travellers with a strong interest in history, archaeology, architecture, the visual arts and the performing arts.Learn more here - https://academytravel.com.au/

In this episode VDH and Jack cover Trump's immigration policies and missing migrant children, Claudine Gay attacking her successor at Harvard, and the alarming parallels between modern America and ancient Rome.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

How do you look ageless at any age? Listen in as Bernadette Fiaschetti and Dr. Michael Aziz discuss his latest book, “The Ageless Revolution: 10 Hallmarks of Aging That Hold the Secret to defeating Disease, Reversing Age, Looking Younger, and Living Longer.”Dr. Michael Aziz is an internist, anti-aging regenerative physician specialist. Board-certified in internal medicine, he is an attending physician at Lennox Hill Hospital in New York City. Dr. Aziz is a frequent contributor to Life Extension Magazine and “The Boardroom Newsletters.” He has been featured in The Los Angeles Times, CNN, Web M.D., the New York Post, the Daily News, the Washington Post, and Woman's World. Dr. Aziz regularly provides medical commentary of NPR, Fox and Friends, ABC, WGN Chicago, NBC and Telemundo. He is the best-selling author of The Perfect 10 Diet: 10 Key Hormones That Hold the Secret to Losing Weight and Feeling Great Fast!  His latest book release is The Ageless Revolution: 10 Hallmarks of Aging That Hold the Secret to Defeating Disease, Reversing Age, Looking Younger, and Living Longer.You can find Dr. Aziz at his website https://www.michaelazizmd.com/ 

The Stuph File Program Featuring Guinness World Record holder, David Rush; Dr. Michael Aziz; & Marc Hartzman, author of The Talking Dead: A Collection Of Messages From Beyond The Veil, 1850's to 1920's Download David Rush is a multiple Guinness World Record holder. His latest feat is being hit 96 times in the face with wet sponges in a single minute. In addition his website, you can also visit his YouTube page. Dr. Michael Aziz discusses why alcohol use in the United States has hit a 90-year low. He's also the author of the best selling, The Perfect 10 Diet, and the new book, The Ageless Revolution: 10 Hallmarks of Aging That Hold the Secret to Defeating Disease, Reversing Age, Looking Younger, and Living Longer. Marc Hartzman, from WeirdHistorian.com and the author of The Talking Dead: A Collection Of Messages From Beyond The Veil, 1850's to 1920's. This week's opening slate is presented by Craig DiLouie is the author of My Ex, The Antichrist. He was a guest back on show #0835.

Send us a textDr. Michael Aziz, M.D. discusses his book: The Ageless Revolution: 10 Hallmarks of Aging That Hold the Secret to Defeating Disease, reversing age, Looking Younger, and Living Longer. Dr. Michael Aziz is a board-certified Internal Medicine physician, author, and a broadcast media commentator. He is as an attending physician at Lenox Hill Hospital in New York City. Dr. Aziz completed his medical training at Long Island Jewish Medical Center and Staten Island University Hospital in New York. He is a member of the American College of Physicians,  the American Society of Internal Medicine, and a fellow of the Royal Society of Medicine in the United Kingdom. Dr. Aziz has also been a keynote speaker at numerous national and international conferences, including those organized by the American Academy of Anti-Aging Medicine.You can find him at: www.michaelazizmd.com

In a fascinating and insightful discussion, I sat down with Dr. Jon Brudvig, a medical scientist and expert in neuroscience and drug development. Together, we explored the science of aging, the critical role of cellular recycling, and the practical steps anyone can take to improve their healthspan. Jon Brudvig shared his journey from rare disease research to longevity science, offering actionable insights into how our daily choices impact the aging process. Such a good conversation, I have split it into two parts. What You'll Learn: The Cellular Foundation of Aging:Discover how Dr. Brudvig’s research into lysosomal storage diseases led him to understand the universal decline in cellular recycling (autophagy and lysosomal function) as a key driver of aging. Autophagy Explained:Learn why autophagy—the body’s process of breaking down and recycling damaged cellular components—is essential for health, and how modern lifestyles can disrupt this natural cycle. The Fundamentals of Longevity:Understand why exercise, diet, sleep, vitamin D, omega-3s, and real-life social connections are the true building blocks of a long and healthy life. Mouse Models and Human Longevity:Gain perspective on the limitations of animal studies in longevity research, and why findings in mice don’t always translate directly to humans. The mTOR Pathway and Protein Intake:Explore the debate around the mTOR pathway, protein consumption, and how balancing periods of growth and rest may be the key to optimal aging. Healthspan vs. Lifespan:Reflect on the difference between living longer and living better, and why increasing your years of good health (healthspan) is a more realistic and valuable goal than chasing extreme longevity. Key Takeaways: Aging is cellular: The decline in lysosomal and autophagy function is a core driver of aging and disease. Autophagy matters: Fasting, exercise, and periodic stressors help trigger the body’s natural recycling processes. Master the basics: Exercise, a balanced diet, quality sleep, and strong social ties are the most effective longevity interventions. Be cautious with quick fixes: Not all supplements or drugs that work in mice will work in humans—focus on proven fundamentals first. Balance is key: Intermittent activation of growth pathways (like mTOR) through meals and exercise, balanced with periods of rest, supports healthy aging. Protein quality counts: Mix your protein sources and prioritise whole foods for optimal health outcomes. Connect with Dr. Jon Brudvig for more insights into longevity and health: LinkedIn: Jon Brudvig Substack: https://jonbrudvig.substack.com/ 00:53 Dr. Brudvig’s Background and PhD Focus01:22 Gene Therapy and Lysosomal Storage Diseases02:45 Connecting Rare Diseases to Aging03:10 Lysosomal Function and Aging03:40 Professional Work in Drug Development04:01 The Link Between Professional and Personal Interests04:22 The Role of Lysosomes in Autophagy04:40 What is Autophagy?04:54 Why Autophagy Matters for Cellular Health05:07 The Recycling Analogy: Cells as Master Recyclers05:26 Evolutionary Importance of Autophagy06:14 Autophagy, Fasting, and Modern Lifestyles07:07 The Impact of Modern Comfort on Health07:28 Social Media, Longevity, and Biohacks08:00 The Interventions Testing Program Explained08:42 Mouse Studies and Their Limitations09:32 The Importance of Fundamentals: Exercise, Diet, Sleep10:22 Omega-3s and Social Networks for Longevity11:00 The Hallmarks of Aging11:40 Homeostasis and the Aging Process12:20 Healthspan vs. Lifespan: Which Matters More?13:07 The Two Camps in Longevity Science13:51 Promising Interventions: SGLT2 Inhibitors and Rapamycin14:45 Rapamycin: Hype, Dosing, and Human Application15:53 mTOR Pathway, Protein Intake, and Longevity17:00 Balancing mTOR Activation and Autophagy18:00 Practical Protein Advice: Whey, Collagen, and Plant-Based Sources18:45 Final Thoughts: Eat Real Food and Mix Protein Sources See omnystudio.com/listener for privacy information.

What if aging wasn't just something that happens to us, but something science could actually slow down? That's the question at the heart of today's conversation with Dr. Matt Kaeberlein, who's a leading scientist and longevity researcher at the University of Washington.Dr. Kaeberlein has spent decades decoding the biology of aging, from cellular mechanisms to practical strategies that could extend not just how long we live, but how well we live. In this episode, we talked about surprising connections between aging and brain health, and looked into the research around lithium and Alzheimer's to see what the latest science is telling us about extending healthspan.It is an informative discussion on whether aging itself can be slowed or reversed. If you're curious about how close we really are to changing the rules of aging, this could be worth a watch.Chapters:00:00 – Introduction & The Biology of Aging Across Species10:57 – The Struggles of Change, GLP-1 Drugs & The Power of Sleep14:33 – The Hallmarks of Aging21:52 – Funding Issues23:22 – The Truth About Anti-Aging Drugs27:22 – Biological Age Testing 48:23 – Biomarkers, Advanced Testing & The Limits of Diagnostics01:02:50 – Micronutrient Testing and Supplements01:07:11 –  NAD, Smarter Longevity Choices01:18:05 –  Lithium's Secret Role in Aging and Memory Loss01:27:00 – Foundations of Longevity01:57:37 - Ovarian Aging02:01:02 – Closing Thoughts & Where to Find the Guest Guest's socials + website:YouTube: https://www.youtube.com/@optispanX: https://x.com/mkaeberlein?lang=enWebsite: https://www.optispan.life/ Kayla's social + website:Instagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter: https://x.com/femalelongevity Website: https://www.kaylabarnes.com/Follow Her Female Protocol: https://www.protocol.kaylabarnes.com/Become a Member of Kayla's Female Longevity Membership: https://kayla-barnes-lentz.circle.so/checkout/become-a-member

What if aging wasn't just something that happens to us, but something science could actually slow down? That's the question at the heart of today's conversation with Dr. Matt Kaeberlein, who's a leading scientist and longevity researcher at the University of Washington.Dr. Kaeberlein has spent decades decoding the biology of aging, from cellular mechanisms to practical strategies that could extend not just how long we live, but how well we live. In this episode, we talked about surprising connections between aging and brain health, and looked into the research around lithium and Alzheimer's to see what the latest science is telling us about extending healthspan.It is an informative discussion on whether aging itself can be slowed or reversed. If you're curious about how close we really are to changing the rules of aging, this could be worth a watch.Chapters00:00 – Introduction & The Biology of Aging Across Species10:57 – The Struggles of Change, GLP-1 Drugs & The Power of Sleep14:33 – The Hallmarks of Aging21:52 – Funding Issues23:22 – The Truth About Anti-Aging Drugs27:22 – Biological Age Testing 48:23 – Biomarkers, Advanced Testing & The Limits of Diagnostics01:02:50 – Micronutrient Testing and Supplements01:07:11 –  NAD, Smarter Longevity Choices01:18:05 –  Lithium's Secret Role in Aging and Memory Loss01:27:00 – Foundations of Longevity01:57:37 - Ovarian Aging02:01:02 – Closing Thoughts & Where to Find the Guest Guest's socials + websiteYouTube: https://www.youtube.com/@optispanX: https://x.com/mkaeberlein?lang=enWebsite: https://www.optispan.life/ Kayla's social + website:Instagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter: https://x.com/femalelongevity Website: https://www.kaylabarnes.com/Follow Her Female Protocol: https://www.protocol.kaylabarnes.com/Become a Member of Kayla's Female Longevity Membership: https://kayla-barnes-lentz.circle.so/checkout/become-a-member

Welcome back to Casting Actors Cast, the podcast for actors who want to sharpen their audition skills, book more roles, and understand the industry from the inside out. Today we're diving into a genre that's deceptively challenging, yet absolutely essential for so many working actors: Romantic Comedies and Hallmark-style films. These projects have their own flavor—light, charming, heartfelt, and often sprinkled with humor and predictability. But here's the catch: what works in a dramatic audition often doesn't work here. If you overplay the depth, you miss the levity. If you underplay it, you risk seeming flat or uninspired. So, how do you strike that perfect balance? In this episode, we'll explore the hallmarks of rom-com acting—the specific skill set that helps actors shine in both auditions and on set. Whether you're preparing for a Hallmark Christmas movie or a witty rom-com pilot, you'll walk away with practical tools to deliver the style directors and casting directors are looking for. Learn more about your ad choices. Visit megaphone.fm/adchoices

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Josh Spitalnick is a clinical and research psychologist with expertise in treating a variety of anxiety conditions with cognitive-behavioral therapy (CBT) and other evidence-based approaches. In this episode, Josh unpacks the four layers of anxiety—psychological, emotional, cognitive, and behavioral—highlighting why avoidance is the key feature that transforms ordinary worry into disorder. He explains why he continues to treat OCD and PTSD as anxiety conditions despite their DSM-5 reclassification, and he draws important distinctions between worries versus worrying and thoughts versus thinking. The discussion explores health anxiety, illness anxiety, and the impact of modern contributors such as wearables, social media, and the COVID era, while weaving in real-world case studies and Josh's structured assessment approach. Josh also breaks down evidence-based treatments, from exposure therapy and cognitive-behavioral therapy (CBT) to acceptance and commitment therapy (ACT), along with the role of medication, lifestyle factors, and how shifting from avoidance to committed action can build long-term resilience. We discuss: Josh's professional background and his holistic approach to treating anxiety [3:00]; Definition of anxiety and changes in the DSM-5 [5:00]; The psychological and cognitive aspects of anxiety [10:45]; Breaking down anxiety symptoms: triggers, fears, and hidden mental rituals [17:00]; Thoughts versus thinking and worries versus worrying: what constitutes dysfunction [20:15]; Health anxiety and the limits of medical reassurance: understanding illness anxiety and somatic symptom disorder [24:30]; Triggering events for health anxiety, symptom fixation, heritability, and the role of nature versus nurture [36:30]; Historical and modern shifts in health anxiety, from HIV/AIDS in the 1980s to today's heightened fears of cancer [45:30]; Modern factors and recent events that have amplified societal anxiety levels [47:15]; Josh's approach to patients with excessive health-related rituals and/or OCD using CBT and exposure therapy [54:30]; Hypothetical example of treating a person with a fear of flying: assessment, panic disorder, and the role of medication and exposure therapy [1:03:15]; The four types of exposure therapy and the shift from habituation to inhibitory learning [1:14:00]; Treating people with OCD that manifests in disturbing and intrusive thoughts, and why therapy focuses on values over reassurance [1:21:00]; Acceptance and commitment therapy (ACT): reorienting patients toward values-driven living rather than symptom elimination [1:31:45]; Mindfulness as a tool to cultivate presence, awareness, and healthy engagement with life [1:36:30]; Hallmarks of successful therapy and red-flags that therapy is not going well [1:38:15]; The relationship between anxiety and substance use, and the therapeutic challenges it creates [1:44:45]; Anxiety's overlap with ADHD, OCD, autism, and physical health conditions [1:49:45]; Debunking the harmful myth that health anxiety is a “made up” condition [1:51:30]; Prevalence, severity, and evolving treatments for health anxiety and OCD [1:54:45]; Treating health anxiety is about providing patients with skills to improve quality of life—a discussion on how to address symptoms often attributed to long COVID [2:01:30]; Balancing the benefits of abundant health information with the risks of fueling health anxiety [2:06:30]; Advice for finding a telehealth provider with expertise in health anxiety [2:11:00]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

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#168 - Better Than Botox? 9 Science-Proven Ways to Slow Aging at the Mitochondrial Cellular Level   If your energy is tanked, your skin looks older, and your brain feels like it's buffering—don't blame age, blame your mitochondria. In fact, mitochondrial dysfunction is one of the 12 Hallmarks of Aging.    In this episode of Pretty Well, I'm breaking down how these tiny powerhouses inside your cells control everything from how you age to how well you think, move, and recover. We'll cover 9 evidence-based ways to protect your mitochondria and even boost mitochondrial biogenesis (fancy for “make more of the good stuff”) so that you can slow and even reverse signs of aging. From red light therapy and fasting options to targeted nutrients and why your mitochondria love colorful veggies more than you do—this is the anti-aging roadmap you actually want to follow. No gimmicks, no $400 serums. Just real tools to feel younger, stronger, and sharper from the inside out. Because aging is inevitable—but doing it tired, inflamed, and foggy is not. LInks & Resources: Journal Article: Hallmarks of aging: An expanding universe Carlos López-Otín, Maria A. Blasco, Linda Partridge, Manuel Serrano, Guido Kroemer; Volume 186, Issue 2, 19 January 2023; https://doi.org/10.1016/j.cell.2022.11.001 https://www.sciencedirect.com/science/article/pii/S0092867422013770 Amazon Links:  *As An Amazon Associate I Earn A Small Commission From Qualifying Purchases At No Extra Cost To You*   Mito Red Light Panel: https://amzn.to/4mG3Ax9 Mito Red Light Therapy Glasses - Eye Protection for Red Light (600nm-900nm) - Goggles: https://amzn.to/4oKBiDw HigherDOSE Red Light Therapy Face Mask: https://amzn.to/4ctcIRN Dr. Dennis Gross FaceWare Pro Mask for Anti-Aging, Acne Treatment, and Skin Rejuvenation with Dual Red & Blue Light Therapy: https://amzn.to/42kFWO2    Pure Encapsulations Mitochondria-Supporting Supplements: Mitochondria ATP https://amzn.to/426au7i    NR Longevity https://amzn.to/4cpjsjD    B complex Plus https://amzn.to/4lj1yTD  B complex with PQQ and ALA https://amzn.to/4i3Kv54    CoQ 10 (active form Ubiquinol) https://amzn.to/4lisnHA    Acetyl-L-Carnitine 250 mg https://amzn.to/3G0eBJA Acetyl-L-Carnitine 500 mg https://amzn.to/4jmFxl1    Magnesium Glycinate https://amzn.to/4iWlvhx  Magnesium Citrate https://amzn.to/4ldRPy1    Saccharomyces boulardii (probiotic) https://amzn.to/3DXc4zg    Join the conversation: Share your thoughts with us on social media or in the comments! Subscribe, Share & Review: 

When a rejected kiss turns into a brawl - People drinking "Feel Free" bottles - Flashing headlights to warn bad people - Being safe at the gas pump - A random egg found on the ground turns into a beautiful friendship - Truth behind Hallmarks ornaments and much much more  

Angela talks to Kylen Ribeiro, in a show designed to explore the often-overlooked topic of electromagnetic fields (EMFs) and radiation, discussing their potential health impacts and ways to protect ourselves. Kylen explains the spectrum of EMF radiation, from low-frequency sources like electrical devices to higher-frequency signals from cell phones and Wi-Fi. Check out Defender Shield's products and save 10% with code ANGELA at Defendershield.com/angela EMF Radiation Chart: https://defendershield.com/pages/electromagnetic-spectrum KEY TAKEAWAYS Understanding EMFs: Electromagnetic field radiation (EMF) encompasses various signals emitted from devices like cell phones, Wi-Fi, and even battery-powered items Health Risks: Long-term exposure to EMFs can lead to serious health issues, including brain tumors, DNA damage, and fertility problems Children's Vulnerability: Children are more susceptible to EMF exposure due to their developing brains and bodies Practical Solutions: To minimise EMF exposure, individuals can use protective products such as EMF-blocking phone cases, AirTube headphones, and clothing designed to shield against radiation TIMESTAMPS AND KEY TOPICS [00:00:18] EMF radiation explained. [00:21:47] Children's vulnerability to EMF exposure. [00:38:09] Bedroom environment for better sleep. [00:49:10] EMF exposure and animal health. [01:00:22] Tech-free habits for children. VALUABLE RESOURCES Click here for discounts on all the products I personally use and recommend A BIG thank you to our sponsors who make the show possible: Oxford Healthspan Primeadine: Target 9 out of the 12 Hallmarks of Aging - click here and use code ANGELA to save 15% ABOUT THE GUEST Kylen is the Chief Executive Officer at DefenderShield, and is responsible for leading the strategic growth of the company. After growing up in Raleigh, NC, Kylen moved to Tallahassee, FL to complete her lifelong swimming career at Florida State University as the Women's Swimming and Diving Team Captain. Kylen graduated with a B.S. in Marketing and Management and married her fellow teammate turned husband. She continued her education as a Seminole and went on to earn her Masters in Business Administration. ABOUT THE HOST Angela Foster is an award winning Nutritionist, Health & Performance Coach, Speaker and Host of the High Performance Health podcast. A former Corporate lawyer turned industry leader in biohacking and health optimisation for women, Angela has been featured in various media including Huff Post, Runners world, The Health Optimisation Summit, BrainTap, The Women's Biohacking Conference, Livestrong & Natural Health Magazine. Angela is the creator of BioSyncing®️ a blueprint for ambitious entrepreneurial women to biohack their health so they can 10X how they show up in their business and their family without burning out. CONTACT DETAILS Instagram Facebook LinkedIn Disclaimer: The High Performance Health Podcast is for general information purposes only and do not constitute the practice of professional or coaching advice and no client relationship is formed. The use of information on this podcast, or materials linked from this podcast is at the user's own risk. The content of this podcast is not intended to be a substitute for medical or other professional advice

Let's talk about the real work of being the CEO of your business — not just chasing results, but learning how to discern what's truly aligned, what's a distraction, and when it's time to make a bold move (or just sit tight).If you've ever been stuck in the fog of: “Should I pivot?” “Am I out of alignment?” “Why isn't this working?”Or worse, if you've been spiraling after a launch that flopped or questioning everything because you're not growing at lightning speed then please listen to this episode.Inside, I'm walking you through the 5 key markers of a CEO mindset, the kind of mindset that allows you to stay grounded even when business feels chaotic, and helps you build maturity as a founder over time.We'll dive into:How to know if it's time to pivot or stay the courseThe surprising truth about “alignment” and what's usually underneath itWhy your strengths + long-term vision matter more than trends or sunk costsThe danger of mistaking your life for your business (multi-passionates, I see you)Why timeline panic is sabotaging your success more than anything elseThis is an episode you'll want to come back to anytime you're in a wobble. I've been where you are, and this is what I'd tell you if we were having coffee together right now.Bingeworthy BundlesIf you want to grow faster and get more clients from Instagram (while spending less time posting) – this should helpIf you want to create or grow your podcast – this is for youIf you want to work part-time hours but have an offer suite that makes multi-six figures – you'll love thisIf you want to turn more likes into leads – here's what's working nowIf you're deciding on a course or membership platform – try this.

Let's talk about the real work of being the CEO of your business — not just chasing results, but learning how to discern what's truly aligned, what's a distraction, and when it's time to make a bold move (or just sit tight).If you've ever been stuck in the fog of:“Should I pivot?”“Am I out of alignment?”“Why isn't this working?”Or worse, if you've been spiraling after a launch that flopped or questioning everything because you're not growing at lightning speed — then please listen to this episode.Inside, I'm walking you through the 5 key markers of a CEO mindset — the kind of mindset that allows you to stay grounded even when business feels chaotic, and helps you build maturity as a founder over time.We'll dive into:How to know if it's time to pivot or stay the courseThe surprising truth about “alignment” and what's usually underneath itWhy your strengths + long-term vision matter more than trends or sunk costsThe danger of mistaking your life for your business (multi-passionates, I see you)Why timeline panic is sabotaging your success more than anything elseThis is an episode you'll want to come back to anytime you're in a wobble. I've been where you are, and this is what I'd tell you if we were having coffee together right now.Join the waitlist for my signature offer launching in September: Peace + Profit Mastermind— you'll get first dibs, insider updates, and a few juicy surprises before the doors open.Bingeworthy BundlesIf you want to grow faster and get more clients from Instagram (while spending less time posting) – this should helpIf you want to create or grow your podcast – this is for youIf you want to work part-time hours but have an offer suite that makes multi-six figures – you'll love thisIf you want to turn more likes into leads – here's what's working nowIf you're deciding on a course or membership platform – try this.

For this bitesize, Angela presents a piece of her conversation with Laura Hof, examining the transformative power of the Wim Hof Method, particularly focusing on the benefits of ice baths and breathing techniques for managing stress and enhancing emotional regulation. They discuss how overcoming the immediate stress response triggered by ice baths serves as a metaphor for tackling various stressors in life, ultimately fostering resilience and confidence KEY TAKEAWAYS Ice Bath as a Metaphor for Overcoming Stress: Engaging in an ice bath serves as a powerful metaphor for confronting various stressors in life, such as work challenges or personal limitations Cross Adaptation and Stress Resilience: The practice of enduring an ice bath leads to cross adaptation, where the skills learned in managing one type of stress can be applied to other stressors in life Impact on Emotional Regulation: Women, particularly high achievers, benefit significantly from improved emotional regulation through methods like the Wim Hof technique Scientific Evidence of Brain Changes: Studies indicate that practicing the Wim Hof method can lead to measurable changes in the brain, such as increased activity in the CB1 receptor TIMESTAMPS AND KEY TOPICS [00:00:10] Overcoming stress through ice baths. [00:08:04] Nervous system regulation techniques. [00:08:22] Nervous system balance and flexibility. VALUABLE RESOURCES Click here for discounts on all the products I personally use and recommend Check out my blog to learn How Spermidine Can Reset Your Sleep and Hormonal Balance During Perimenopause A BIG thank you to our sponsors who make the show possible: Oxford Healthspan Primeadine: Target 9 out of the 12 Hallmarks of Aging - click here and use code ANGELA to save 15% Listen to the full episode at https://lnk.to/EP452 ABOUT THE HOST Angela Foster is an award winning Nutritionist, Health & Performance Coach, Speaker and Host of the High Performance Health podcast. A former Corporate lawyer turned industry leader in biohacking and health optimisation for women, Angela has been featured in various media including Huff Post, Runners world, The Health Optimisation Summit, BrainTap, The Women's Biohacking Conference, Livestrong & Natural Health Magazine. Angela is the creator of BioSyncing®️ a blueprint for ambitious entrepreneurial women to biohack their health so they can 10X how they show up in their business and their family without burning out. The High Performance Health Podcast is a top rated global podcast. Each week, Angela brings you a new insight, biohack or high performance habit to help you unlock optimal health, longevity and higher performance. Hit the follow button to make sure you get notified each time Angela releases a new episode. CONTACT DETAILS Instagram Facebook LinkedIn Affiliate Disclaimer: Note this description contains affiliate links that allow you to find the items mentioned in this video and support the channel at no cost to you. While this channel may earn minimal sums when the viewer uses the links, the viewer is under no obligation to use these links. Thank you for supporting the show! Disclaimer: The High Performance Health Podcast is for general information purposes only and do not constitute the practice of professional or coaching advice and no client relationship is formed. The use of information on this podcast, or materials linked from this podcast is at the user's own risk. The content of this podcast is not intended to be a substitute for medical or other professional advice, diagnosis, or treatment. Users should seek the assistance of their medical doctor or other health care professional for before taking any steps to implement any of the items discussed in this podcast.

Angela talks to Stuart Sandeman about the profound impact of breath on our emotional and physical well-being. They explore how trauma and life experiences can manifest in our bodies, particularly through breathing patterns, and discuss the importance of breathwork in releasing stored tension and emotions. Stuart also shares his personal journey of grief following the loss of his girlfriend and how breathwork helped him process his emotions. KEY TAKEAWAYS Breath and Emotion Connection: The way we breathe is closely linked to our emotional state. Short, shallow breathing often correlates with feelings of anxiety or fear, while deeper, more expansive breathing is associated with feelings of calm and joy. Breathing Archetypes: Individuals have different breathing patterns or archetypes that reflect their emotional and psychological states.  Impact of Trauma on Breath: Traumatic experiences can lead to physical tension and altered breathing patterns. This tension is often held in specific areas of the body Breathwork for Emotional Release: Engaging in breathwork can facilitate the release of stored emotions and trauma TIMESTAMPS AND KEY TOPICS [00:02:01] Breath and emotional release. [00:07:40] Somatic release through breathwork. [00:23:06] Breath awareness and archetypes. [00:36:39] Managing public speaking nerves. [00:45:12] Breath and energy alignment. [00:51:04] Creating space for daily practice. [00:57:20] Optimal breathing rate for health. [01:03:30] Breathing patterns and personal change. [00:00:00] Hypnotic accents and conversation. VALUABLE RESOURCES Click here for discounts on all the products I personally use and recommend A BIG thank you to our sponsors who make the show possible: Oxford Healthspan Primeadine: Target 9 out of the 12 Hallmarks of Aging - click here and use code ANGELA to save 15% LVLUP HEALTH: Slow aging, repair gut health boost collagen and recovery and more with LVLUP Health's amazing products. Save 15% with code ANGELA at https://lvluphealth.com/angela ABOUT THE HOST Angela Foster is an award winning Nutritionist, Health & Performance Coach, Speaker and Host of the High Performance Health podcast. A former Corporate lawyer turned industry leader in biohacking and health optimisation for women, Angela has been featured in various media including Huff Post, Runners world, The Health Optimisation Summit, BrainTap, The Women's Biohacking Conference, Livestrong & Natural Health Magazine. Angela is the creator of BioSyncing®️ a blueprint for ambitious entrepreneurial women to biohack their health so they can 10X how they show up in their business and their family without burning out. The High Performance Health Podcast is a top rated global podcast. Each week, Angela brings you a new insight, biohack or high performance habit to help you unlock optimal health, longevity and higher performance. Hit the follow button to make sure you get notified each time Angela releases a new episode. CONTACT DETAILS Instagram Facebook LinkedIn Affiliate Disclaimer: Note this description contains affiliate links that allow you to find the items mentioned in this video and support the channel at no cost to you. While this channel may earn minimal sums when the viewer uses the links, the viewer is under no obligation to use these links. Thank you for supporting the show! Disclaimer: The High Performance Health Podcast is for general information purposes only and do not constitute the practice of professional or coaching advice and no client relationship is formed. The use of information on this podcast, or materials linked from this podcast is at the user's own risk. The content of this podcast is not intended to be a substitute for medical or other professional advice, diagnosis, or treatment. Users should seek the assistance of their medical doctor or other health care professional for before taking any steps to implement any of the items discussed in this podcast.

Riley Jensen joined DJ & PK to examine what will go into the three-man race to emerge as the BYU starting quarterback to replace Jake Retzlaff for Kalani Sitake and the BYU Cougars.

In this week's episode, we'll learn about using AI to assess transplant risk in myelofibrosis. In a step toward personalized medicine, researchers report on a machine learning model that identifies 25% of patients with poor outcomes. After that: preventing priapism in men with sickle cell anemia. A recent phase 2 feasibility study shows high rates of recruitment, retention, and adherence to oral therapies, coupled with a significant reduction in the risk of this difficult complication. Finally, new research indicates that hallmarks of terminal T-cell exhaustion are absent in multiple myeloma, from diagnosis through maintenance therapy. We explore these provocative and counterintuitive findings arising from profiling of blood and marrow samples.Featured Articles:Use of machine learning techniques to predict poor survival after hematopoietic cell transplantation for myelofibrosisA controlled trial for preventing priapism in sickle cell anemia: hydroxyurea plus placebo vs hydroxyurea plus tadalafilHallmarks of T-cell exhaustion and antigen experience are absent in multiple myeloma from diagnosis to maintenance therapy

Dr. Kelly Halderman joins us at Vitality Made Simple to shed light on one of the most empowering areas of modern health: the biology of aging. She walks us through the 12 scientifically recognized Hallmarks of Aging and explains how understanding these drivers gives us a roadmap to aging smarter. Dr. Halderman also shares how her own health crisis, marked by neurological symptoms and a grim medical prognosis, led her to explore naturopathic and functional medicine, eventually leading her to become a leading expert in translational medicine and nutrigenomics.She explains how by identifying these genetic ‘snips' and understanding how they are expressed through epigenetics, individuals can design precision-based strategies to delay aging and prevent chronic disease. The episode is packed with practical insights: from the importance of detoxifying your environment to why stress, oral health, and blood sugar regulation are critical components of your longevity plan. Whether you're looking to live longer, feel better, or simply make more informed decisions about your health, this conversation delivers both inspiration and clarity.Visit my website DrDebbieOzment.com for valuable free downloads. Additionally, you will find shopping links which I have curated on the website. Please follow me on instagram at drdebbieozment.

Welcome to season 2!Today we're talking about Phoenix Springs by Calligram Studio! A game about asking the right questions and following a guide.Play Phoenix Springs on Steam! Check out the guide on Calligram Studio's website!Discussed in the episode:Ligne claire on WikipediaMystery and Melancholy of a Street, 1914 - Giorgio de Chirico on WikiArtPhoenix Springs has a secret to tell you by Katie and Catburger on YouTubeThis Point and Click Adventure Plays With Your Mind by Matt J. Wilson on YouTubePhoenix Springs - Walkthrough on Calligram Studio's websiteIsle of the Dead, 1883 - by Arnold Böcklin on WikiArtFred Durst on WikipediaIs Every Game REALLY Political? by No Pun Included on YouTube---Visit our website!Support the show on Kofi!Follow us on Twitch!Follow the show on Bluesky!Check out The Worst Garbage Online!---Art by Tara CrawfordTheme music by _amaranthineAdditional sounds by BoqehProduced and edited by AJ Fillari---Timecodes:(00:00) - 1 podcast, 1 game, 3 hosts = INNOCENT! (00:54) - This one's been a long time coming (02:44) - What is Phoenix Springs (03:43) - The artstyle (07:54) - The game is confusing

Sonja Bindus, teacher support lead for Hillsdale College K-12 Education, joins host Scot Bertram to discuss making the most of the summer, minimizing screen time, and summer activities that are both fun and educational. Learn more: https://k12.hillsdale.edu/See omnystudio.com/listener for privacy information.

In this episode of Karma School of Business, Sean Mooney sits down with Misha Logvinov, Managing Director and New York Office Lead at MGX, to discuss the essential lessons he's learned throughout his entrepreneurial journey and private equity career. Together, they explore actionable insights on leadership, adaptability, and leveraging technology for value creation in private equity and beyond. Episode Highlights: 1:19 - Misha's Early Journey: Growing up in post-Soviet Russia, launching entrepreneurial ventures as a teen, and transitioning to Silicon Valley during the dotcom boom. 7:22 - Entry into Private Equity: Misha describes his unplanned move into private equity after years as a tech operator and entrepreneur. 13:43 - Hallmarks of Great Companies: Key factors Misha looks for in businesses poised for success, including strong leadership, adaptability, and robust tech infrastructure. [00:18:31] Value Creation at MGX: How MGX helps portfolio companies grow by integrating cutting-edge AI and data strategies. [00:23:16] Actionable Advice: Misha highlights the importance of prioritizing data readiness, embracing AI for operational improvement, and rethinking leadership approaches for the future. [00:33:44] Advice to Younger Self: Misha reflects on the importance of balancing drive with kindness while pursuing high performance. For more information on MGX, go to https://www.mgx.ae/en For more information on Misha Logvinov, go to https://www.linkedin.com/in/mlogvinov For more information on BluWave and this podcast, go to https://www.bluwave.net/podcasts

What if the key to lasting behavior change, personal growth, and feeling more confident wasn't about setting epic goals—but running tiny experiments? In this mind-expanding episode, Angela sits down with Anne-Laure Le Cunff—founder of Ness Labs and author of Tiny Experiments—to explore how small tests rooted in curiosity can lead to powerful transformations in every area of your life. From alcohol-free living to productivity hacks, sleep rhythms, and navigating health advice in the age of information overwhelm, this conversation will shift your perspective on goal-setting and self-optimization. Anne-Laure shares why most people get stuck trying to rationalize decisions instead of following data from their own lived experience—and how becoming an “agent of change” helps us reclaim control in an ever-changing world. KEY TAKEAWAYS: The Problem with Pros & Cons Lists: We often use them to justify decisions we've already made rather than explore truth objectively. How to Run Tiny Experiments: Focus on curiosity, one measurable variable, and a fixed timeframe to discover what truly works for you. Why Habit Challenges Often Fail: Without curiosity and internal motivation, behavior doesn’t shift—experimentation creates sustainable change. The Plus-Minus-Next Framework: A simple self-reflection tool to assess what’s working, what’s not, and what to try next—without judgment. Letting Go of Epic Goals: Big dreams can be paralyzing—often, purpose and passion emerge through action, not planning. Becoming Your Own Scientist: Whether it’s a new supplement, workout time, or meditation habit, take charge with your own data-informed experiments. TIMESTAMPS AND KEY TOPICS 00:00 – Introduction 04:30 – Angela’s alcohol experiment and how it evolved into 1000+ days 08:45 – What defines a “tiny experiment” and why it’s powerful 16:10 – Internal vs external signals as better decision-making tools 20:55 – How to track experiments without high-tech tools 25:10 – The importance of a stable environment during experimentation 28:30 – Tiny experiments for productivity and writing routines 34:00 – Daily vs weekly reflection and when to stop tracking 43:45 – The trap of “epic dreams” and how real purpose evolves VALUABLE RESOURCES Click here for discounts on all the products I personally use and recommend Check out my blog to learn How Spermidine Can Reset Your Sleep and Hormonal Balance During Perimenopause A BIG thank you to our sponsors who make the show possible: Oxford Healthspan Primeadine: Target 9 out of the 12 Hallmarks of Aging - click here and use code ANGELA to save 15% LVLUP HEALTH: Slow aging, repair gut health boost collagen and recovery and more with LVLUP Health’s amazing products. Save 15% with code ANGELA at https://lvluphealth.com/angela ABOUT THE GUEST Anne-Laure Le Cunff is an award-winning neuroscientist and entrepreneur. She is the founder of Ness Labs, where her weekly newsletter is read by more than 100,000 curious minds. Her research at King’s College London focuses on the psychology and neuroscience of lifelong learning, curiosity, and adaptability. Her book, Tiny Experiments, is a transformative guide for living a more experimental life, turning uncertainty into curiosity, and carving a path of self-discovery. Previously, she worked at Google as an executive on digital health projects. Her work has been featured in Rolling Stone, Forbes, Financial Times, WIRED, and more. ABOUT THE HOST Angela Foster is an award winning Nutritionist, Health & Performance Coach, Speaker and Host of the High Performance Health podcast. A former Corporate lawyer turned industry leader in biohacking and health optimisation for women, Angela has been featured in various media including Huff Post, Runners world, The Health Optimisation Summit, BrainTap, The Women’s Biohacking Conference, Livestrong & Natural Health Magazine. Angela is the creator of BioSyncing®️ a blueprint for ambitious entrepreneurial women to biohack their health so they can 10X how they show up in their business and their family without burning out. The High Performance Health Podcast is a top rated global podcast. Each week, Angela brings you a new insight, biohack or high performance habit to help you unlock optimal health, longevity and higher performance. Hit the follow button to make sure you get notified each time Angela releases a new episode. CONTACT DETAILS Instagram Facebook LinkedIn Affiliate Disclaimer: Note this description contains affiliate links that allow you to find the items mentioned in this video and support the channel at no cost to you. While this channel may earn minimal sums when the viewer uses the links, the viewer is under no obligation to use these links. Thank you for supporting the show! Disclaimer: The High Performance Health Podcast is for general information purposes only and do not constitute the practice of professional or coaching advice and no client relationship is formed. The use of information on this podcast, or materials linked from this podcast is at the user's own risk. The content of this podcast is not intended to be a substitute for medical or other professional advice, diagnosis, or treatment. Users should seek the assistance of their medical doctor or other health care professional for before taking any steps to implement any of the items discussed in this podcast.

Angela dives deep with special guest Nikolina Lauc on the subject of biological aging and the role of glycans in our immune system. They discuss how glycans, complex sugars that coat our cells, influence our biological aging and immune function, particularly in the context of chronic inflammation. Nikolina explains the differences between various biological age tests, such as telomere and methylation testing, highlighting the advantages of glycan testing for individual assessments. KEY TAKEAWAYS Glycans are complex sugars that play a crucial role in cellular communication and immune function. They influence biological aging by affecting inflammation and immune responses, with changes in glycan patterns indicating shifts in health status over time. Biological age can differ significantly from chronological age, as it reflects the state of one's immune system and overall health. Glycan testing provides a more accurate measure of biological age, allowing individuals to understand their health trajectory better. Chronic stress, whether from work or personal life, can accelerate biological aging. Lifestyle factors such as exercise, sleep, and nutrition significantly influence glycan profiles, with moderate exercise being beneficial while excessive training can lead to increased inflammation. Women experience a notable acceleration in biological aging during perimenopause due to declining estrogen levels, which can lead to increased inflammation. Hormone replacement therapy (HRT) can help mitigate this effect and improve glycan age. BEST MOMENTS "Glycans are complex sugars... Most of our molecules have glycans as a component, so all cells are coated in these complex sugars." "Bad news is also good news if you're looking at the glycan perspective, because we would see these different glycosylation patterns change up to 10 years prior to symptoms." "Stress is in your mind or it's a mind response... We're the only species that can create this fight or flight without actually having to run from a lion." "If you have acceleration in glycogen as an individual, this is predictive of an outcome, mortality, morbidity." VALUABLE RESOURCES Click here for discounts on all the products I personally use and recommend A BIG thank you to our sponsors who make the show possible: Supercharge your energy and upgrade your mitochondria with Mitopure - go to timeline.com/angela and enter code ANGELA to save 10% Target 9 out of the 12 Hallmarks of Aging with Oxford Healthspan Primeadine - and use code ANGELA to save 15% Test your biological age and gain powerful insights into your longevity and health at www.glycanage.com - use code ANGELA15 for your exclusive listener discount Come join us inside the High Performance Health Collective—your space to learn how to work with your female physiology to live longer, stronger, and more energised—with a bonus peek into my private biological age consult to show you exactly how I’m reversing the clock - angelafosterperformance.com/hph-collective ABOUT THE HOST Angela Foster is an award winning Nutritionist, Health & Performance Coach, Speaker and Host of the High Performance Health podcast. A former Corporate lawyer turned industry leader in biohacking and health optimisation for women, Angela has been featured in various media including Huff Post, Runners world, The Health Optimisation Summit, BrainTap, The Women’s Biohacking Conference, Livestrong & Natural Health Magazine. Angela is the creator of BioSyncing®️ a blueprint for ambitious entrepreneurial women to biohack their health so they can 10X how they show up in their business and their family without burning out. The High Performance Health Podcast is a top rated global podcast. Each week, Angela brings you a new insight, biohack or high performance habit to help you unlock optimal health, longevity and higher performance. Hit the follow button to make sure you get notified each time Angela releases a new episode. CONTACT DETAILS Instagram Facebook LinkedIn Affiliate Disclaimer: Note this description contains affiliate links that allow you to find the items mentioned in this video and support the channel at no cost to you. While this channel may earn minimal sums when the viewer uses the links, the viewer is under no obligation to use these links. Thank you for supporting the show! Disclaimer: The High Performance Health Podcast is for general information purposes only and do not constitute the practice of professional or coaching advice and no client relationship is formed. The use of information on this podcast, or materials linked from this podcast is at the user's own risk. The content of this podcast is not intended to be a substitute for medical or other professional advice, diagnosis, or treatment. Users should seek the assistance of their medical doctor or other health care professional for before taking any steps to implement any of the items discussed in this podcast.