Podcasts about hallmarks

In this episode of Karma School of Business, Sean Mooney sits down with Misha Logvinov, Managing Director and New York Office Lead at MGX, to discuss the essential lessons he's learned throughout his entrepreneurial journey and private equity career. Together, they explore actionable insights on leadership, adaptability, and leveraging technology for value creation in private equity and beyond. Episode Highlights: 1:19 - Misha's Early Journey: Growing up in post-Soviet Russia, launching entrepreneurial ventures as a teen, and transitioning to Silicon Valley during the dotcom boom. 7:22 - Entry into Private Equity: Misha describes his unplanned move into private equity after years as a tech operator and entrepreneur. 13:43 - Hallmarks of Great Companies: Key factors Misha looks for in businesses poised for success, including strong leadership, adaptability, and robust tech infrastructure. [00:18:31] Value Creation at MGX: How MGX helps portfolio companies grow by integrating cutting-edge AI and data strategies. [00:23:16] Actionable Advice: Misha highlights the importance of prioritizing data readiness, embracing AI for operational improvement, and rethinking leadership approaches for the future. [00:33:44] Advice to Younger Self: Misha reflects on the importance of balancing drive with kindness while pursuing high performance. For more information on MGX, go to https://www.mgx.ae/en For more information on Misha Logvinov, go to https://www.linkedin.com/in/mlogvinov For more information on BluWave and this podcast, go to https://www.bluwave.net/podcasts

What if the key to lasting behavior change, personal growth, and feeling more confident wasn't about setting epic goals—but running tiny experiments? In this mind-expanding episode, Angela sits down with Anne-Laure Le Cunff—founder of Ness Labs and author of Tiny Experiments—to explore how small tests rooted in curiosity can lead to powerful transformations in every area of your life. From alcohol-free living to productivity hacks, sleep rhythms, and navigating health advice in the age of information overwhelm, this conversation will shift your perspective on goal-setting and self-optimization. Anne-Laure shares why most people get stuck trying to rationalize decisions instead of following data from their own lived experience—and how becoming an “agent of change” helps us reclaim control in an ever-changing world. KEY TAKEAWAYS: The Problem with Pros & Cons Lists: We often use them to justify decisions we've already made rather than explore truth objectively. How to Run Tiny Experiments: Focus on curiosity, one measurable variable, and a fixed timeframe to discover what truly works for you. Why Habit Challenges Often Fail: Without curiosity and internal motivation, behavior doesn’t shift—experimentation creates sustainable change. The Plus-Minus-Next Framework: A simple self-reflection tool to assess what’s working, what’s not, and what to try next—without judgment. Letting Go of Epic Goals: Big dreams can be paralyzing—often, purpose and passion emerge through action, not planning. Becoming Your Own Scientist: Whether it’s a new supplement, workout time, or meditation habit, take charge with your own data-informed experiments. TIMESTAMPS AND KEY TOPICS 00:00 – Introduction 04:30 – Angela’s alcohol experiment and how it evolved into 1000+ days 08:45 – What defines a “tiny experiment” and why it’s powerful 16:10 – Internal vs external signals as better decision-making tools 20:55 – How to track experiments without high-tech tools 25:10 – The importance of a stable environment during experimentation 28:30 – Tiny experiments for productivity and writing routines 34:00 – Daily vs weekly reflection and when to stop tracking 43:45 – The trap of “epic dreams” and how real purpose evolves VALUABLE RESOURCES Click here for discounts on all the products I personally use and recommend Check out my blog to learn How Spermidine Can Reset Your Sleep and Hormonal Balance During Perimenopause A BIG thank you to our sponsors who make the show possible: Oxford Healthspan Primeadine: Target 9 out of the 12 Hallmarks of Aging - click here and use code ANGELA to save 15% LVLUP HEALTH: Slow aging, repair gut health boost collagen and recovery and more with LVLUP Health’s amazing products. Save 15% with code ANGELA at https://lvluphealth.com/angela ABOUT THE GUEST Anne-Laure Le Cunff is an award-winning neuroscientist and entrepreneur. She is the founder of Ness Labs, where her weekly newsletter is read by more than 100,000 curious minds. Her research at King’s College London focuses on the psychology and neuroscience of lifelong learning, curiosity, and adaptability. Her book, Tiny Experiments, is a transformative guide for living a more experimental life, turning uncertainty into curiosity, and carving a path of self-discovery. Previously, she worked at Google as an executive on digital health projects. Her work has been featured in Rolling Stone, Forbes, Financial Times, WIRED, and more. ABOUT THE HOST Angela Foster is an award winning Nutritionist, Health & Performance Coach, Speaker and Host of the High Performance Health podcast. A former Corporate lawyer turned industry leader in biohacking and health optimisation for women, Angela has been featured in various media including Huff Post, Runners world, The Health Optimisation Summit, BrainTap, The Women’s Biohacking Conference, Livestrong & Natural Health Magazine. Angela is the creator of BioSyncing®️ a blueprint for ambitious entrepreneurial women to biohack their health so they can 10X how they show up in their business and their family without burning out. The High Performance Health Podcast is a top rated global podcast. Each week, Angela brings you a new insight, biohack or high performance habit to help you unlock optimal health, longevity and higher performance. Hit the follow button to make sure you get notified each time Angela releases a new episode. CONTACT DETAILS Instagram Facebook LinkedIn Affiliate Disclaimer: Note this description contains affiliate links that allow you to find the items mentioned in this video and support the channel at no cost to you. While this channel may earn minimal sums when the viewer uses the links, the viewer is under no obligation to use these links. Thank you for supporting the show! Disclaimer: The High Performance Health Podcast is for general information purposes only and do not constitute the practice of professional or coaching advice and no client relationship is formed. The use of information on this podcast, or materials linked from this podcast is at the user's own risk. The content of this podcast is not intended to be a substitute for medical or other professional advice, diagnosis, or treatment. Users should seek the assistance of their medical doctor or other health care professional for before taking any steps to implement any of the items discussed in this podcast.

Angela dives deep with special guest Nikolina Lauc on the subject of biological aging and the role of glycans in our immune system. They discuss how glycans, complex sugars that coat our cells, influence our biological aging and immune function, particularly in the context of chronic inflammation. Nikolina explains the differences between various biological age tests, such as telomere and methylation testing, highlighting the advantages of glycan testing for individual assessments. KEY TAKEAWAYS Glycans are complex sugars that play a crucial role in cellular communication and immune function. They influence biological aging by affecting inflammation and immune responses, with changes in glycan patterns indicating shifts in health status over time. Biological age can differ significantly from chronological age, as it reflects the state of one's immune system and overall health. Glycan testing provides a more accurate measure of biological age, allowing individuals to understand their health trajectory better. Chronic stress, whether from work or personal life, can accelerate biological aging. Lifestyle factors such as exercise, sleep, and nutrition significantly influence glycan profiles, with moderate exercise being beneficial while excessive training can lead to increased inflammation. Women experience a notable acceleration in biological aging during perimenopause due to declining estrogen levels, which can lead to increased inflammation. Hormone replacement therapy (HRT) can help mitigate this effect and improve glycan age. BEST MOMENTS "Glycans are complex sugars... Most of our molecules have glycans as a component, so all cells are coated in these complex sugars." "Bad news is also good news if you're looking at the glycan perspective, because we would see these different glycosylation patterns change up to 10 years prior to symptoms." "Stress is in your mind or it's a mind response... We're the only species that can create this fight or flight without actually having to run from a lion." "If you have acceleration in glycogen as an individual, this is predictive of an outcome, mortality, morbidity." VALUABLE RESOURCES Click here for discounts on all the products I personally use and recommend A BIG thank you to our sponsors who make the show possible: Supercharge your energy and upgrade your mitochondria with Mitopure - go to timeline.com/angela and enter code ANGELA to save 10% Target 9 out of the 12 Hallmarks of Aging with Oxford Healthspan Primeadine - and use code ANGELA to save 15% Test your biological age and gain powerful insights into your longevity and health at www.glycanage.com - use code ANGELA15 for your exclusive listener discount Come join us inside the High Performance Health Collective—your space to learn how to work with your female physiology to live longer, stronger, and more energised—with a bonus peek into my private biological age consult to show you exactly how I’m reversing the clock - angelafosterperformance.com/hph-collective ABOUT THE HOST Angela Foster is an award winning Nutritionist, Health & Performance Coach, Speaker and Host of the High Performance Health podcast. A former Corporate lawyer turned industry leader in biohacking and health optimisation for women, Angela has been featured in various media including Huff Post, Runners world, The Health Optimisation Summit, BrainTap, The Women’s Biohacking Conference, Livestrong & Natural Health Magazine. Angela is the creator of BioSyncing®️ a blueprint for ambitious entrepreneurial women to biohack their health so they can 10X how they show up in their business and their family without burning out. The High Performance Health Podcast is a top rated global podcast. Each week, Angela brings you a new insight, biohack or high performance habit to help you unlock optimal health, longevity and higher performance. Hit the follow button to make sure you get notified each time Angela releases a new episode. CONTACT DETAILS Instagram Facebook LinkedIn Affiliate Disclaimer: Note this description contains affiliate links that allow you to find the items mentioned in this video and support the channel at no cost to you. While this channel may earn minimal sums when the viewer uses the links, the viewer is under no obligation to use these links. Thank you for supporting the show! Disclaimer: The High Performance Health Podcast is for general information purposes only and do not constitute the practice of professional or coaching advice and no client relationship is formed. The use of information on this podcast, or materials linked from this podcast is at the user's own risk. The content of this podcast is not intended to be a substitute for medical or other professional advice, diagnosis, or treatment. Users should seek the assistance of their medical doctor or other health care professional for before taking any steps to implement any of the items discussed in this podcast.

Folge 92: Ernährung, VO₂max, Mitochondrien, Regeneration: Was wirklich wirkt – für Gesundheit, Leistung und LanglebigkeitWie kann Ernährung uns nicht nur fitter, sondern auch gesünder alt werden lassen? Dr. Matthias Riedl – Ernährungsmediziner, Bestsellerautor und ARD-Ernährungs-Doc – erklärt im Gespräch mit Andreas Butz, worauf es bei gesunder Langlebigkeit wirklich ankommt. Sein Buch Die Longevity-Food-Formel zeigt: Essen ist mehr als Kalorienbilanz – es ist der Schlüssel zu mehr Energie, besserem Schlaf, stabiler Regeneration und besserer sportlicher Leistung. Wir sprechen über:

BUFFALO, NY — April 21, 2025 — A new #research paper was #published in Aging (Aging-US) Volume 17, Issue 3, on March 14, 2025, titled “Effects of a natural ingredients-based intervention targeting the hallmarks of aging on epigenetic clocks, physical function, and body composition: a single-arm clinical trial.” A team of researchers, led by first authors Natalia Carreras-Gallo and Rita Dargham, and corresponding author Varun B. Dwaraka from TruDiagnostic, studied how a natural anti-aging supplement called the Cel System might influence the aging process. They found that participants who took the supplement for one year showed a reduction in biological age, along with improved muscle strength and body composition. The study highlights the potential of lifestyle and nutritional supplements to support healthy aging. “The Cel System supplement range was formulated to target pathways associated with the Hallmarks of Aging when combining Cel1, Cel2, and Cel3 formulas.” Cel System is a natural supplement made from a mix of plant compounds, vitamins, and antioxidants designed to target the biological mechanisms associated with aging. Over the course of a year, 51 adults between the ages of 54 and 84 participated in the clinical trial. The group included 26 men and 25 women. Researchers tracked changes in biological age using DNA-based tests known as epigenetic clocks, along with physical performance and body composition metrics. Participants were also encouraged to walk for 10 minutes and practice mindfulness for five minutes daily. Results showed that participants experienced improvements in grip strength, lower body mobility, and reductions in body weight, waist circumference, and body mass index. These physical gains were supported by slower biological aging, as measured by multiple epigenetic clocks. In addition, the supplement appeared to reduce stem cell turnover, a key marker of aging at the cellular level. The study also reported changes in immune cell composition, suggesting that the supplement may help regulate immune function as people age. Biomarkers associated with liver function also shifted, pointing to potential improvements in organ health. However, levels of inflammation markers did not significantly change. Analysis of methylation chemical marks on DNA revealed that the supplement influenced gene activity related to stress response, brain function, and cell communication. These molecular-level changes may help explain the broader benefits seen in physical and biological aging measures. Although this was a pilot study without a control group, the findings suggest that the Cel System supplement shows potential for reducing signs of aging and improving overall health. The authors suggest future randomized controlled trials with larger sample sizes to confirm these results and explore the supplement's long-term effects on longevity. This study adds to growing evidence that targeted natural supplements may slow biological aging and extend healthspan. By combining epigenetic analysis with real-world health data, the findings offer new insight into how nutraceuticals, like Cel System, could promote long-term health and resilience. Paper: DOI: https://doi.org/10.18632/aging.206221 Corresponding author: Varun B. Dwaraka – varun.dwaraka@trudiagnostic.com Keywords: aging, epigenetic age change, physiological age change, epigenetic biomarker proxies, hallmarks of aging, nutraceutical longevity interventions To learn more about the journal, please visit our website at www.Aging-US.com​​ and connect with us on social media at: Facebook - www.facebook.com/AgingUS/ X - twitter.com/AgingJrnl Instagram - www.instagram.com/agingjrnl/ YouTube - www.youtube.com/@AgingJournal LinkedIn - www.linkedin.com/company/aging/ Pinterest - www.pinterest.com/AgingUS/ Spotify - open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Angela welcomes back Ben Azadi, author of the new book "Metabolic Freedom" to delve into the critical differences between metabolic freedom and the common state of metabolic prison, where individuals are trapped in a cycle of sugar burning and insulin resistance. Ben shares insights from his extensive research, stressing the importance of maintaining balanced blood sugar levels and the role of muscle mass in enhancing insulin sensitivity, while Angela recounts her personal journey with PCOS and how dietary changes transformed her health. KEY TAKEAWAYS Many individuals are trapped in a "metabolic prison," primarily burning sugar for energy, which can lead to insulin resistance and various health issues. In contrast, metabolic freedom allows the body to efficiently switch between burning sugar and fat, promoting better energy levels and overall health. High insulin levels are a precursor to metabolic diseases, including diabetes and heart disease. Regular testing of fasting insulin levels is crucial for assessing metabolic health, with optimal levels being in the single digits. Increasing muscle mass through strength training enhances insulin sensitivity and helps regulate blood sugar levels. Maintaining muscle as one ages can prevent metabolic slowdown and promote better health outcomes. Focusing solely on calorie counting can be misleading. Instead, prioritizing the quality of food—such as whole, unprocessed foods—can lead to better hormonal balance and overall health, making weight loss a natural side effect of improved health. Chronic stress can lead to elevated cortisol levels, which promote fat storage and hinder fat burning. Managing stress through various methods, including exercise and mindfulness, is essential for maintaining metabolic health and overall well-being. BEST MOMENTS "Unfortunately, most people are in a metabolic prison. They're handcuffed by food in order to have some short energy... when you are stuck burning sugar, it's not a fun way to live." "I think the misconception is that if we don't have good control of our metabolism, then we're going to look overweight. I certainly didn't... I was slim and fit and looked fine." "High levels of insulin... it's the first domino to fall that leads to all these metabolic diseases. It starts with high blood pressure, you start gaining weight, and then it's pre-diabetes." "We have a slight advantage insofar as we have a menstrual cycle and we can check what's going on... I think that maybe we're a little more conscious of our health because we get these signs." VALUABLE RESOURCES Click here for discounts on all the products I personally use and recommend Check out my blog to learn How Spermidine Can Reset Your Sleep and Hormonal Balance During Perimenopause A BIG thank you to our sponsors who make the show possible: Oxford Healthspan Primeadine: Target 9 out of the 12 Hallmarks of Aging - click here and use code ANGELA to save 15% LVLUP HEALTH: Slow aging, repair gut health boost collagen and recovery and more with LVLUP Health’s amazing products. Save 15% with code ANGELA at https://lvluphealth.com/angela Sign up to my Fresh Start Newsletter: Start your week feeling in control with one simple, science-backed step for your hormones, health and longevity—get your free weekly fresh start at angelafoster.me/freshstart ABOUT THE GUEST In 2008, Ben Azadi went through a personal health transformation of shredding 80 pounds of pure fat. Ever since, Ben Azadi, FDN-P, has been on a mission to help 1 billion people live a healthier lifestyle. Ben is the author of four best-selling books, Keto Flex, The Perfect Health Booklet, The Intermittent Fasting Cheat Sheet, and The Power of Sleep. Ben has been the go-to source for intermittent fasting and the ketogenic diet. He is known as 'The Health Detective' because he investigates dysfunction, and he educates, not medicates, to bring the body back to normal function. Ben is the founder of Keto Kamp; a global brand bringing awareness to ancient healing strategies such as the keto diet and fasting. Ben is the host of a top 15 podcast, The Keto Kamp Podcast; and the fast growing Keto Kamp YouTube channel with over 130,000 subscribers, and TikTok channel with over 145,000 subscribers. ABOUT THE HOST Angela Foster is an award winning Nutritionist, Health & Performance Coach, Speaker and Host of the High Performance Health podcast. A former Corporate lawyer turned industry leader in biohacking and health optimisation for women, Angela has been featured in various media including Huff Post, Runners world, The Health Optimisation Summit, BrainTap, The Women’s Biohacking Conference, Livestrong & Natural Health Magazine. Angela is the creator of BioSyncing®️ a blueprint for ambitious entrepreneurial women to biohack their health so they can 10X how they show up in their business and their family without burning out. The High Performance Health Podcast is a top rated global podcast. Each week, Angela brings you a new insight, biohack or high performance habit to help you unlock optimal health, longevity and higher performance. Hit the follow button to make sure you get notified each time Angela releases a new episode. CONTACT DETAILS Instagram Facebook LinkedIn Affiliate Disclaimer: Note this description contains affiliate links that allow you to find the items mentioned in this video and support the channel at no cost to you. While this channel may earn minimal sums when the viewer uses the links, the viewer is under no obligation to use these links. Thank you for supporting the show! Disclaimer: The High Performance Health Podcast is for general information purposes only and do not constitute the practice of professional or coaching advice and no client relationship is formed. The use of information on this podcast, or materials linked from this podcast is at the user's own risk. The content of this podcast is not intended to be a substitute for medical or other professional advice, diagnosis, or treatment. Users should seek the assistance of their medical doctor or other health care professional for before taking any steps to implement any of the items discussed in this podcast.

The dating and relationship world is rife with blindsided breakups. Is this the hallmark of an Avoidant? Counsellor Ken Reid is here to discuss Fearful and Dismissive Avoidants and explain why this heartbreaking scenario is so often the upshot of their relationship trajectory. Counsellor Ken Reid is the go-to source for all things ATTACHMENT THEORY. His work includes relationship challenges, breakups, grief, and communication skills. He also serves the LGBTQIA+ community. Defining fearful and dismissive avoidants Hallmarks and “Tells” of an Avoidant The Blindsided Breakup Strategy Website: https://www.kenreidcounselling.com.au Spotify: https://podcasters.spotify.com/pod/show/kenreads Work with Me: Consultation: Books: Breakup Triage; The Cure for Heartache Audible Allowing Magnificence; Living the Expanded Version of Your Life - Book and Audiobook: Connect with Me! Website: susanwinter.net YouTube: YouTube Channel Instagram: Instagram Profile Twitter: Twitter Profile Facebook: Facebook Page LinkedIn: LinkedIn Profile TikTok: TikTok Profile

In this episode of Beauty is a Bitch, I'm joined by Dr. Michael Aziz, a board-certified internist, regenerative medicine expert, and author of the bestselling The Perfect 10 Diet. His latest book, The Ageless Revolution: 10 Hallmarks of Aging That Hold the Secret to Defeating Disease, Reversing Age, Looking Younger, and Living Longer, explores how we can slow down aging and prevent disease—starting at the cellular level. We dive into some of the top anti-aging foods you should be eating now (hint: your kitchen may already have a few), and why gut health and healthy fats play a critical role in how well we age. Dr. Aziz also shares why certain restrictive diets—including vegetarian, low-carb, and keto—may not be the best choice for long-term health and vitality, especially for women in midlife. If you're curious about how to support your body from the inside out and make smarter food choices that align with graceful, healthy aging—this episode is packed with insight, practical tips, and maybe even a few surprises. Don't miss it! Show Notes: Book: The Ageless Revolution: 10 Hallmarks of Aging That Hold the Secret to Defeating Disease, Reversing Age, Looking Younger, and Living Longer Book: The Perfect 10 Diet: 10 Key Hormones That Hold The Secret to Losing Weight & Feeling Great - Fast!

In today's episode, we sat down with Liliana Bustamante, MD, and Jessica Stine, MD, to discuss their experiences as women in oncology. Dr Bustamante is a medical oncologist and hematologist at Florida Cancer Specialists & Research Institute in Tampa. Dr Stine is the medical director of Gynecologic Oncology at Florida Cancer Specialists & Research Institute. In our exclusive interview, Drs Bustamante and Stine discussed their unique journeys toward choosing careers in oncology, the emotional fulfillment of treating patients with cancer, the importance of mentorship between colleagues, and the evolving nature of work-life balance. They also emphasize the importance of honesty, peer support, and self-grace in navigating oncology careers.

Aging doesn't have to mean decline — in fact, what if you could slow it down or even reverse it? In this episode, Chris Mirabile, founder of NOVOS, breaks down the 12 Hallmarks of Aging and how understanding them can help you live a longer, healthier life. From mitochondria to telomeres, Chris shares the science behind why we age, the lifestyle changes that make the biggest impact, and how NOVOS created the first formula targeting all 12 aging mechanisms. He also shares his personal story of overcoming a brain tumor at 16, what inspired his passion for longevity, and why he now has a biological age 14 years younger than his chronological age. If you've ever wondered what's possible when science meets self-care, this conversation will change the way you think about aging and your future health.The information presented in Fully Alive is for educational and informational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition or treatment and before making changes to your health regimen. Guests' opinions are their own and do not necessarily reflect those of the podcast host, production team, or sponsors.

Angela talks to Leslie Kenny, about the fascinating world of longevity and health optimisation. Leslie, a renowned expert in the field, shares her personal journey of reversing her biological age to 21 at the age of 59, focussing upon the importance of a multifactorial approach to aging that includes diet, movement, sleep, and social connection. Together Angela and Leslie discuss the often-overlooked significance of sleep and social interactions, as well as the role of the microbiome in health. Leslie also introduces the powerful compound spermidine, found in various plant-based foods, and its benefits for autophagy, immune health, and even hair pigmentation KEY TAKEAWAYS Focus on diet, movement, sleep, and social connection to optimise health and longevity. Prioritising sleep is particularly crucial for reducing risks associated with Alzheimer's and dementia. Each individual has a unique microbiome influenced by their ancestry, which affects how they process different foods. Identifying and removing personal dietary "kryptonite" (foods that trigger negative responses) while incorporating beneficial foods is essential for optimal health. This compound, found in various plant-based foods, activates autophagy, a cellular renewal process. Increasing spermidine intake can support gut health, immune function, and even hair pigmentation by promoting the growth phase of hair follicles. Fasting can have different effects on men and women, particularly during perimenopause. Women may experience negative hormonal changes and stress responses from prolonged fasting, making it essential to find alternative ways to stimulate autophagy, such as through spermidine supplementation. BEST MOMENTS "Aging is a multifactorial problem, so it needs to be solved with a multifactorial approach. Focus on these four pillars: diet, movement, sleep, and social connection." "The more plants we can get into our diet, the better, both for fiber and because there are lots of polyphenols... spermidine activates that cell renewal process known as autophagy." "The greater the diversity of the gut biome, the healthier the person is, the more resilient the microbiome is and able to respond to challenges." "When we think about fasting... it isn't always suitable for women, particularly those in high-stress jobs or going through perimenopausal transition." VALUABLE RESOURCES Click here for discounts on all the products I personally use and recommend A BIG thank you to our sponsors who make the show possible: Oxford Healthspan: Target 9 out of the 12 Hallmarks of Aging with Oxford Healthspan Primeadine - and use code ANGELA to save 15% LVLUP HEALTH: Slow aging, repair gut health boost collagen and recovery and more with LVLUP Health’s amazing products. Save 15% with code ANGELA at https://lvluphealth.com/angela LUMEN: Develop metabolic flexibility and remove the guesswork with Lumen - use code ANGELA for your exclusive discount at http://angelafoster.me/lumen ABOUT THE GUEST Leslie’s Kenny is an Oxford-based, Harvard-educated CEO and patient advocate whose life took a dramatic turn in her late 30s when she was diagnosed with Lupus, Rheumatoid Arthritis, and Hashimoto’s Thyroiditis, told she had five years to live and that she could give up on having children. Refusing to accept this prognosis, she transformed her health by eliminating inflammatory triggers and supporting her body’s natural healing. Now 59, she has the biological age of 21, is autoimmune disease-free, and naturally conceived at 43. Empowered by her health journey, she returned to school, became a certified Bulletproof coach and began working with Oxford University scientists, helping them raise funding for their groundbreaking research. In a meeting with Professor Katja Simon, she discovered spermidine, a powerful, natural compound dubbed as an “anti-aging vitamin” and found to “delay aging in humans” through its ability to activate autophagy (cell renewal) and target key aging pathways. Recognizing its potential, she founded Oxford Healthspan, launching Primeadine®, a plant-derived spermidine supplement, with the highest quality, Japanese ingredients and the backing of top scientific and clinical advisors. She also collaborated with University of Oxford academics to co-found a non-profit organization, called the Oxford Longevity Project, dedicated to educating the public on easy, actionable ways to improve their healthspan and longevity. oxfordhealthspan.com lesliesnewprime.com oxfordlongevityproject.org https://www.instagram.com/oxfordhealthspan/ https://www.instagram.com/lesliesnewprime/ https://www.instagram.com/oxfordlongevityproject/ ABOUT THE HOST Angela Foster is an award winning Nutritionist, Health & Performance Coach, Speaker and Host of the High Performance Health podcast. A former Corporate lawyer turned industry leader in biohacking and health optimisation for women, Angela has been featured in various media including Huff Post, Runners world, The Health Optimisation Summit, BrainTap, The Women’s Biohacking Conference, Livestrong & Natural Health Magazine. Angela is the creator of BioSyncing®️ a blueprint for ambitious entrepreneurial women to biohack their health so they can 10X how they show up in their business and their family without burning out. The High Performance Health Podcast is a top rated global podcast. Each week, Angela brings you a new insight, biohack or high performance habit to help you unlock optimal health, longevity and higher performance. Hit the follow button to make sure you get notified each time Angela releases a new episode. CONTACT DETAILS Instagram Facebook LinkedIn Affiliate Disclaimer: Note this description contains affiliate links that allow you to find the items mentioned in this video and support the channel at no cost to you. While this channel may earn minimal sums when the viewer uses the links, the viewer is under no obligation to use these links. Thank you for supporting the show! Disclaimer: The High Performance Health Podcast is for general information purposes only and do not constitute the practice of professional or coaching advice and no client relationship is formed. The use of information on this podcast, or materials linked from this podcast is at the user's own risk. The content of this podcast is not intended to be a substitute for medical or other professional advice, diagnosis, or treatment. Users should seek the assistance of their medical doctor or other health care professional for before taking any steps to implement any of the items discussed in this podcast.

Im Zuge meiner Recherche für mein kommendes Buch "Longevity Basics - Prävention, statt Reaktion" möchte ich dir Einblicke über die 12 Gründe, wieso wir altern geben.Ich bin mir sicher, dass du hier definitiv etwas neues erfahren wirst!===NUTZE DIE KOMMENTARFUNKTION VON SPOTIFY:Hybrid-Training & HYROX - welche Erfahrungen hast du damit bereits gemacht?===Mehr über Carsten:Instagram: https://www.instagram.com/functional.basics/LinkedIn: https://www.linkedin.com/in/carsten-w%C3%B6lffling-4b08b3141/===

Angela talks to Joe Cohen, founder of SelfDecode about the power of DNA testing and how understanding one's genetic code can unlock insights into predispositions for diseases, optimal supplements, and dietary needs. Joe shares his personal journey of health optimisation, discussing the importance of combining genetic information with blood work to create actionable health strategies. KEY TAKEAWAYS DNA as a Health Compass: Your DNA holds key clues about your risks, strengths, and how to personalise your health plan. Not All DNA Tests Are Equal: Many tests look at too few variants. SelfDecode uses millions to give accurate, usable insights. Genes Aren’t Destiny: Even if you have high genetic risk, your environment and habits can still shape your outcomes. Precision Supplements: Knowing your genes can guide which supplements actually work for your body. Tracking Matters: Blood tests, wearables, and advanced genetic analysis together give the most powerful health roadmap. Smart Lifestyle Tweaks: DNA risk helps guide diet, exercise, and supplement choices so you don’t waste time guessing. Functional Goals > Diagnosis: This episode shifts focus from diagnosing disease to optimising performance and energy. TIMESTAMPS AND KEY TOPICS: 0:05 – Genetics can predict health risks, supplement needs, and more6:57 – Joe's health journey and obsession with optimisation9:47 – Do supplements harm your liver? Joe explains12:09 – Why testing (not just blood) is key to tracking health19:49 – LDL vs ApoB: how genes and lifestyle interact23:37 – Lp(a) is harder to shift due to strong genetic ties28:11 – What Joe takes to lower LDL naturally32:20 – Why Joe chooses to eat saturated fat38:17 – Not all DNA tests are helpful—many lack depth42:00 – MTHFR is just one part of the methylation picture47:52 – Why InsideTracker isn’t reliable for genetics54:53 – SelfDecode mimics & improves on other reports56:07 – What’s next: Angela will upload her results for part two VALUABLE RESOURCES Click here for discounts on all the products I personally use and recommend Get a free snapshot of your health and personalised report at www.yourtotalhealthcheck.com Join The High Performance Health Community A BIG thank you to our sponsors who make the show possible: LVLUP HEALTH: Slow aging, repair gut health boost collagen and recovery and more with LVLUP Health’s amazing products. Save 15% with code ANGELA at https://lvluphealth.com/angela Oxford Healthspan Primeadine: Target 9 out of the 12 Hallmarks of Aging - click here and use code ANGELA to save 15% Supercharge your energy and upgrade your mitochondria with Mitopure - go to timeline.com/angela and enter code ANGELA to save 10% ABOUT THE GUEST Joe Cohen transformed his health by ditching conventional medicine and decoding his DNA. Through a personalized approach, he discovered his genetic weaknesses and was able to optimize his health 10X better than he ever thought was possible. This success led him to create SelfDecode, the most advanced DNA & precision health software, providing AI-driven insights. Today, SelfDecode has helped over 200,000 people, thousands of clinics and 75+ companies which are built on the SelfDecode tech to bring personalized health with DNA to the masses. SelfDecode is trailblazing on the cutting edge of AI and genomics.Joe takes 200 supplements a day, fixed 75 health issues and has optimized 400 lab parameters, and has one of the lowest rates of aging in the world. On his free time, he's a health coach to some of the top health influencers. @Mrbiohacker Selfdecode.com ABOUT THE HOST Angela Foster is an award winning Nutritionist, Health & Performance Coach, Speaker and Host of the High Performance Health podcast. A former Corporate lawyer turned industry leader in biohacking and health optimisation for women, Angela has been featured in various media including Huff Post, Runners world, The Health Optimisation Summit, BrainTap, The Women’s Biohacking Conference, Livestrong & Natural Health Magazine. Angela is the creator of BioSyncing®️ a blueprint for ambitious entrepreneurial women to biohack their health so they can 10X how they show up in their business and their family without burning out. The High Performance Health Podcast is a top rated global podcast. Each week, Angela brings you a new insight, biohack or high performance habit to help you unlock optimal health, longevity and higher performance. Hit the follow button to make sure you get notified each time Angela releases a new episode. CONTACT DETAILS Instagram Facebook LinkedIn Affiliate Disclaimer: Note this description contains affiliate links that allow you to find the items mentioned in this video and support the channel at no cost to you. While this channel may earn minimal sums when the viewer uses the links, the viewer is under no obligation to use these links. Thank you for supporting the show! Disclaimer: The High Performance Health Podcast is for general information purposes only and do not constitute the practice of professional or coaching advice and no client relationship is formed. The use of information on this podcast, or materials linked from this podcast is at the user's own risk. The content of this podcast is not intended to be a substitute for medical or other professional advice, diagnosis, or treatment. Users should seek the assistance of their medical doctor or other health care professional for before taking any steps to implement any of the items discussed in this podcast.

What if everything we thought we knew about cancer was wrong? For decades, scientists have debated what really causes cancer. Is it genetic mutations, as the Somatic Mutation Theory suggests? Is it a metabolic dysfunction, as the Metabolic Theory argues? Or is there a deeper, overlooked truth—one that could redefine cancer treatment as we know it? In this episode, Dr. Ralph Moss and Ben Moss break down the battle between competing cancer theories, why conventional wisdom is being challenged, and what the latest research is uncovering about cancer stem cells, metabolism, and the Warburg Effect.

Angela talks to the amazing Laura Hof, about the transformative power of cold exposure and the Wim Hof Method, exploring how these practices can enhance mental resilience and emotional regulation. Laura shares her extensive experience in guiding individuals through the challenges of cold exposure, emphasising its role as a metaphor for overcoming life's stressors, and highlights the physiological and psychological benefits of ice baths and breathing techniques, including improved stress response, emotional regulation, and even pain relief. “In the interview Laura references a 2024 study of 1114 women. The statistics are - The majority of women with symptoms swam specifically to reduce these symptoms (56.4% for period and 63.3% for perimenopause symptoms.) Of the women using cold water swimming to reduce their symptoms, 85.8% said it alleviated the symptoms due to mental benefits and 92.6% due to physical benefits of the cold as the reason for the reduction of symptoms “ KEY TAKEAWAYS Engaging in ice baths serves as a powerful metaphor for overcoming various stressors in life, helping individuals build resilience and confidence by training their stress response. The Wim Hof Method has been shown to improve emotional regulation, which is particularly beneficial for high-achieving women who often face increased stress and anxiety, especially during perimenopause. Practicing the Wim Hof breathing method can significantly reduce stress sensitivity and improve emotional regulation, making it a valuable tool for managing daily stressors and enhancing decision-making skills. The experience of cold exposure reveals how individuals handle stress in their daily lives. Learning to relax and accept the cold can lead to a stronger mind-body connection, promoting overall well-being. BEST MOMENTS "The ice bath becomes a metaphor for those things that are very hard to do in your life, but you are doing them, overcoming yourself." "When you learn to overcome yourself and that stress response in an ice bath, you literally train to deal with any stress that you have in your life." "Emotional regulation is one of the most important things for women to deal with, especially high achievers." "Doing the hard thing immediately in the morning sets you up for success for the whole day." VALUABLE RESOURCES Get a free snapshot of your health and personalised report at www.yourtotalhealthcheck.com Join The High Performance Health Community A BIG thank you to our sponsors who make the show possible: LVLUP HEALTH: Slow aging, repair gut health boost collagen and recovery and more with LVLUP Health’s amazing products. Save 15% with code ANGELA at https://lvluphealth.com/angela Oxford Healthspan: Target 9 out of the 12 Hallmarks of Aging with Oxford Healthspan Primeadine - www.oxfordhealthspan.com and use code ANGELA to save 15% Pre-order Laura Hof’s brand new book, Secrets of the Icewomem here (link to hide: https://amzn.to/4ipcnS9_ ABOUT THE GUEST Laura Hof, also known as "The Icewoman," is an accomplished wellness expert, speaker, and author, renowned for her expertise in breathwork, cold therapy, and holistic health. She is a Holistic Therapist, and a certified Wim Hof Method (WHM) instructor, following the practices pioneered by her father, Wim Hof, "The Iceman." Laura co-founded the Icewomen Community, a global nature-dipping community led by women. She is also a holistic therapist, investor, businesswoman, and facilitator, moving between Asia and Europe to organize various activities and work as coach, co-facilitator in workshops, retreats and events. www.laurahoffalchemy.com @laura_hof_alchemy Secrets of the Icewomen releasing 29 April 2025, pre order here ABOUT THE HOST Angela Foster is an award winning Nutritionist, Health & Performance Coach, Speaker and Host of the High Performance Health podcast. A former Corporate lawyer turned industry leader in biohacking and health optimisation for women, Angela has been featured in various media including Huff Post, Runners world, The Health Optimisation Summit, BrainTap, The Women’s Biohacking Conference, Livestrong & Natural Health Magazine. Angela is the creator of BioSyncing®️ a blueprint for ambitious entrepreneurial women to biohack their health so they can 10X how they show up in their business and their family without burning out. The High Performance Health Podcast is a top rated global podcast. Each week, Angela brings you a new insight, biohack or high performance habit to help you unlock optimal health, longevity and higher performance. Hit the follow button to make sure you get notified each time Angela releases a new episode. CONTACT DETAILS Instagram Facebook LinkedIn Affiliate Disclaimer: Note this description contains affiliate links that allow you to find the items mentioned in this video and support the channel at no cost to you. While this channel may earn minimal sums when the viewer uses the links, the viewer is under no obligation to use these links. Thank you for supporting the show! Disclaimer: The High Performance Health Podcast is for general information purposes only and do not constitute the practice of professional or coaching advice and no client relationship is formed. The use of information on this podcast, or materials linked from this podcast is at the user's own risk. The content of this podcast is not intended to be a substitute for medical or other professional advice, diagnosis, or treatment. Users should seek the assistance of their medical doctor or other health care professional for before taking any steps to implement any of the items discussed in this podcast.

We hope you enjoy this shiur. If you would like to sponsor or dedicate any of our shiurim or help with the running costs please do not hesitate to get in contact with us at office@rabbiroodyn.com or WhatsApp +447791221449May Hashem heal the wounded, free the captives and lead our soldiers to a swift and painless victory.#jew #jewish #torah #torahfortoughtimes #rabbiroodyn #bringthemhome #rabbi #torahanytime #Judaism #Israel #shiur #responsetotragictimes #jewishunderstanding #kohengadol #beishamikdash #moshiach

Today I'm speaking with Liz Parrish, the founder and CEO of BioViva, on the Longevity Optimization Podcast. In this episode, we explore groundbreaking advancements in gene therapy and its potential to cure age-related diseases. Liz shares her personal journey that led to the creation of BioViva, providing insights into the mechanisms of gene therapy and the current landscape of approved therapies. Our conversation delves into the hallmarks of aging, the role of specific genes like follistatin and telomerase, and the future of gene therapy as a preventative measure for health optimization.Liz Parrish is a pioneering figure in the field of gene therapy, dedicated to advancing the science of longevity and health optimization. Throughout our discussion, she addresses the ethical considerations surrounding gene editing and the implications for future generations. We also discuss the significance of gene therapy in combating aging, the role of telomeres in longevity, and the misconceptions about telomerase and cancer. Additionally, Liz explores the potential benefits of hyperbaric oxygen therapy and shares her personal experiences with gene therapy. The conversation touches on skincare, the philosophy of longevity, and the empowerment of women through advancements in gene therapy, highlighting the transformative potential of these innovations for future health.Let's be friends!Instagram: https://www.instagram.com/kaylabarnes/?hl=enTikTok: https://www.tiktok.com/@femalelongevityX: https://x.com/femalelongevityWebsite: https://kaylabarnes.comJoin Female Longevity Community: https://kayla-barnes-lentz.circle.so/checkout/become-a-member Follow Liz ParrishFollow Her on IG: https://www.instagram.com/lizlparrish/Timestamps00:00 Introduction to Gene Therapy and Longevity03:10 The Birth of BioViva and Personal Motivation06:05 Advancements in Gene Therapy and Regenerative Medicine08:49 Understanding Gene Therapy: Mechanisms and Applications11:56 Current Approved Gene Therapies and Their Impact15:08 Exploring the Hallmarks of Aging17:54 The Role of Folistatin and Telomerase in Aging21:04 Preventative Medicine and Gene Therapy24:02 Future of Gene Therapy and Embryo Editing27:08 The Ethics of Gene Editing and Parental Choices29:54 Preparing for a Multi-Planetary Future39:40 Exploring the Future of Space Travel40:08 The Importance of Safe Space Habitation41:06 Gene Therapy and Aging: A Deeper Dive42:52 Telomeres and Their Role in Longevity46:00 Cancer and Telomerase: Debunking Myths47:55 Hyperbaric Oxygen Therapy: Potential Benefits51:11 Balancing Regeneration and Cellular Division53:26 Pioneering Gene Therapy: A Personal Journey58:27 Measuring the Impact of Gene Therapy01:03:11 Skincare and Longevity: A Personal Approach01:10:24 Philosophy of Longevity: Balancing Life and Health01:14:05 Empowerment Through Gene Therapy for Women

On this episode of Longevity by Design, Dr. Gil Blander speaks with Dr. Michael Ringel, COO of Life Biosciences, about the science of aging and longevity. Michael discusses how evolution influences lifespan and why aging occurs. He explains the trade-off between resource allocation for reproduction versus maintenance and repair within the body. Caloric restriction and its effects on lifespan are explored through an evolutionary lens.Michael highlights the challenges and breakthroughs in longevity research. He touches upon the role of genetics and pharmaceuticals in manipulating lifespan and healthspan. He points to the Pacific rockfish as an example of varying lifespans within a closely related group of species, demonstrating the genetic component of aging. He also notes the impact of Cell reprogramming, referencing a study on how specific Cell reprogramming can regenerate optic nerves.The conversation shifts to the business of longevity, where Michael discusses the increased interest and investments from big pharma and billionaires. He examines the economic benefits of extending healthspan, citing a potential value of $300 trillion from a 10-year healthspan extension in the US alone. Michael and Gil also explore the importance of lifestyle choices for healthy aging, emphasizing diet, exercise, sleep, stress management, and social connections.Guest-at-a-Glance

Anthony ‘Harry' Moffitt retired from the Australian Defence Force after almost 30 years, most of which was spent with Australia's Special Air Service (SAS) Regiment as a Team Commander and Team Specialist. He completed 11 active service deployments and was wounded in action in 2008. He completed his time with the SAS as their Human Performance Manager. Harry is a registered psychologist and runs a human performance consultancy called Stotan Group, which works with sports teams, the military, and the industry. He is also a Director at the Mission Critical Team Institute and founded the Wanderers Education Program, a multi-million dollar not-for-profit that prepares soldiers for transition. He recently published his memoir Eleven Bats, a book about his military service and his love of cricket.Harry has been married to Danielle for 27 years and has two children. He values integrity, humor, and bricolage.More about Harry:Stotan Group: https://stotangroup.com.au/Eleven Bats: https://www.booktopia.com.au/eleven-bats-anthony-harry-moffitt/book/9781760877842.htmlSAS Wanderer's Education Program: https://www.sasresourcesfund.org.au/about-the-fund/wanderers-education-programLBW Trust / National Backyard Cricket: https://lbwtrust.com.au/The Externals (Harry's band): https://www.youtube.com/watch?v=gWSYUvRoa8QInstagram: https://www.instagram.com/harrymoffitt353/Timestamps:00:00:22 Introduction to Harry Moffitt00:01:22 Career Overview00:04:28 Human Performance and Nuance in SAS Selection00:06:16 Success in Selection 00:09:45 Being In Love With The Process00:13:49 Building a Nest: The Ways We Quit00:14:51 The Challenge Beyond Selection00:17:56 Self Doubt: Questioning Your Sense of Belonging00:24:55 Moving On From “You Suck. Suck Less.”00:29:05 Accessing for Integrity00:31:06 Leadership, Character, & Stress00:35:04 Sponsor Note: Building The Elite 00:35:58 Protecting Us From Ourselves00:40:21 Special Operations in Civilian Life: Which Concepts Work? Which Don't?00:45:51 The Hallmarks of Camaraderie00:50:31 Playing ‘Company'00:53:17 The Cricket Bats00:58:30 Harry Moffitt's Next Book01:01:59 Philosophy: Wonder, Intuition, & Imagination01:05:29 Clarifying Values: Your Personal North Star01:11:16 Best and Worst Advice Ever Received01:11:50 Outro

Today I discuss another one of the Hallmarks of Aging - chronic systemic inflammation, and more importantly, what we can do to combat it. See omnystudio.com/listener for privacy information.

Join Layci as she dives into the essential traits that define a world-class team. This episode of Confessions of a Terrible Leader explores high-performance teams, healthy team dynamics, the importance of varied life experiences, and the role of innovation in achieving extraordinary results. Discover the concept of intrapreneurship and extreme ownership, and learn how intentional practice and leadership can cultivate a team that's truly killing it. Whether you're reconfiguring goals at the end of Q1 or aiming to improve your team's output, Layci's insights and practical benchmarks offer valuable guidance for leaders aspiring to transcend the ordinary. Tune in and step into the confessional to hear real stories and gain actionable advice on building elite teams. 00:00 Introduction to Confessions of a Terrible Leader00:26 Meet the Hosts: Layci Nelson and Mary Skop00:44 End of Q1 Reflections and Team Goals01:10 What Makes a World Class Team?02:54 Hallmarks of High-Performance Teams03:46 The Importance of Healthy Team Dynamics09:29 Innovation and Capacity in Teams13:06 Extreme Ownership and Intrapreneurship17:01 Engage with Us on YouTube18:18 Conclusion and Call to ActionCurious to learn more about taking your team to the next level? Reach out to us! We'd love to hear from you! Confessions of a Terrible Leader is hosted by Layci Nelson and edited and produced by Fixation Point Productions. Music is by Leif Olsen and Mary Skop from the band The Number of Months.  

Angela is joined by the amazing Tom Turcich, who shares his extraordinary journey of walking around the world. Tom reflects on the profound lessons he learned during his seven-year trek, particularly the realisation that people are shaped by their environments and circumstances. He discusses the impact of his friend’s death on his decision to embark on this adventure, emphasising the importance of seizing the day, as well as revealing the challenges he faced, including health issues and moments of despair, and the surprising kindness he encountered from people across various cultures. KEY TAKEAWAYS The Power of Walking : Walking forces self-reflection, teaching self-sufficiency and mental resilience. People are Kinder Than We Think : Across different cultures, he experienced generosity and hospitality from strangers. Embracing Constraints Leads to Growth : Accepting life’s limitations helps build a more meaningful and fulfilling experience. Facing Mortality Changes Perspective : A life-changing loss in his teens pushed him to redefine his priorities and live with intention. Nature’s Impact on Mindset : The Atacama Desert and open landscapes brought deep spiritual realizations and a sense of connection. Technology & Distraction : Modern infrastructure and social media influence how we connect; he observed less distraction in places with stronger human interaction. TIMESTAMPS AND KEY TOPICS 0:05 – Walking forces deep self-reflection3:39 – Tom’s seven-year journey across six continents5:41 – Biggest lesson: how small and shaped by environment people are8:36 – Holding onto the dream for eight years before starting14:54 – Packing for extreme weather conditions17:42 – The toughest mental challenge and almost quitting26:07 – Unexpected kindness and lessons from different cultures29:43 – The most dangerous moment: held at gunpoint in Turkey34:49 – Most spiritual place: the Atacama Desert41:34 – How the journey reshaped his perspective on human nature53:39 – Where people are most and least distracted in the world57:37 – Final wisdom: “Go for a walk—it’ll benefit you more than you realize.” VALUABLE RESOURCES Get a free snapshot of your health and personalised report at www.yourtotalhealthcheck.com Join The High Performance Health Community A BIG thank you to our sponsors who make the show possible: Get Your Special Free Gift ($76 value) when you start AG1 at http://DrinkAG1.com/angelafoster Target 9 out of the 12 Hallmarks of Aging with Oxford Healthspan Primeadine - www.oxfordhealthspan.com and use code ANGELA to save 15% To find out more about Tom and his book go to: https://www.tomturcich.com/ ABOUT THE GUEST Tom Turcich is the tenth person to walk around the world, motivational speaker, and photographer. Turcich’s seven-year trek with his adopted Shepard-mix pup, Savannah, took them across six continents and thirty-eight countries. He has been featured on CNN, Good Morning America, Business Insider, The Guardian, The Today Show, Newsweek, and more. ABOUT THE HOST Angela Foster is an award winning Nutritionist, Health & Performance Coach, Speaker and Host of the High Performance Health podcast. A former Corporate lawyer turned industry leader in biohacking and health optimisation for women, Angela has been featured in various media including Huff Post, Runners world, The Health Optimisation Summit, BrainTap, The Women’s Biohacking Conference, Livestrong & Natural Health Magazine. Angela is the creator of BioSyncing®️ a blueprint for ambitious entrepreneurial women to biohack their health so they can 10X how they show up in their business and their family without burning out. The High Performance Health Podcast is a top rated global podcast. Each week, Angela brings you a new insight, biohack or high performance habit to help you unlock optimal health, longevity and higher performance. Hit the follow button to make sure you get notified each time Angela releases a new episode. CONTACT DETAILS Instagram Facebook LinkedIn Affiliate Disclaimer: Note this description contains affiliate links that allow you to find the items mentioned in this video and support the channel at no cost to you. While this channel may earn minimal sums when the viewer uses the links, the viewer is under no obligation to use these links. Thank you for supporting the show! Disclaimer: The High Performance Health Podcast is for general information purposes only and do not constitute the practice of professional or coaching advice and no client relationship is formed. The use of information on this podcast, or materials linked from this podcast is at the user's own risk. The content of this podcast is not intended to be a substitute for medical or other professional advice, diagnosis, or treatment. Users should seek the assistance of their medical doctor or other health care professional for before taking any steps to implement any of the items discussed in this podcast.

Description: Co-hosts Ryan Piansky, a graduate student and patient advocate living with eosinophilic esophagitis (EoE) and eosinophilic asthma, and Holly Knotowicz, a speech-language pathologist living with EoE who serves on APFED's Health Sciences Advisory Council, interview Dr. Wayne Shreffler, Chief of Pediatric Allergy and Immunology and Co-Director of The Food Allergy Center at Massachusetts General Hospital. Dr. Shreffler is also an investigator at The Center for Immunology and Inflammatory Disease and The Food Allergy Science Initiative. His research is focused on understanding how adaptive immunity to dietary antigens is both naturally regulated and modulated by therapy in the context of food allergy. This interview covers the results of a research paper on The Intersection of Food Allergy and Eosinophilic Esophagitis, co-authored by Dr. Shreffler. Disclaimer: The information provided in this podcast is designed to support, not replace the relationship that exists between listeners and their healthcare providers. Opinions, information, and recommendations shared in this podcast are not a substitute for medical advice. Decisions related to medical care should be made with your healthcare provider. Opinions and views of guests and co-hosts are their own.   Key Takeaways: [:50] Co-host Ryan Piansky introduces the episode, brought to you thanks to the support of Education Partners Bristol Myers Squibb, GSK, Sanofi, and Regeneron. Ryan introduces co-host, Holly Knotowicz.   [1:15] Holly introduces today's topic, the intersection of food allergy and eosinophilic esophagitis.   [1:26] Holly introduces today's guest, Dr. Wayne Shreffler, Chief of Pediatric Allergy and Immunology and Co-Director of The Food Allergy Center at Massachusetts General Hospital and an investigator at The Center for Immunology and Inflammatory Disease and The Food Allergy Science Initiative.   [1:43] Dr. Shreffler's research is focused on understanding how adaptive immunity to dietary antigens is both naturally regulated and modulated by therapy in the context of food allergy.   [1:54] Holly welcomes Dr. Shreffler to Real Talk. When Holly moved to Maine, she sent her patients to Dr. Shreffler at Mass General.   [2:25] Dr. Shreffler trained in New York on a Ph.D. track. He was interested in parasitic diseases and the Th2 immune response. Jane Curtis, a program director at Albert Einstein College of Medicine, encouraged him to consider MD/PhD programs. He did.   [3:31] Jane Curtis connected him to Hugh Sampson, who was working with others to help understand the clinical prevalence of food allergy and allergens.   [3:51] As a pediatric resident, Dr. Shreffler had seen the burden of allergic disease, caring for kids in the Bronx with asthma. His interest in Th2 immunity, the clear and compelling unmet clinical need, and the problem of food allergy guided his career.   [4:31] Dr. Shreffler's wife has food allergies and they were concerned for their children. Fortunately, neither of them developed food allergies.   [5:21] Dr. Shreffler thinks the food allergy field has a lot of people who gravitate toward it for personal reasons.   [5:53] Food allergy is an adverse response to food that is immune-mediated. There is still uncertainty about this but Dr. Shreffler believes that a large percentage of patients with EoE have some triggers that are food antigens.   [6:27] The broad definition of food allergy would include things like food protein-induced enterocolitis syndrome (FPIES).   [6:47] The way we use the term food allergy in the clinic, there are two forms: IgE-mediated allergies and non-IgE-mediated allergies, including EoE.   [7:40] Some patients have food-triggered eczema, some have FPIES.   [8:04] In 2024, Dr. Shreffler and Dr. Caitlin Burk released a paper that looked at the triggers of EoE, particularly the intersection of IgE-mediated food allergy and EoE.   [8:41] Dr. Caitlin Burk joined the group as they were publishing papers on IG food allergy and EoE. It was a moment where things unexpectedly came together.   [9:17] Adaptive immunity to food proteins comes from antibodies that cause milk allergy, egg allergy, peanut allergy, or multiple allergies. The IgE has specificity.   [9:40] T cells also are specific to proteins. They express a host of receptors that recognize almost anything the immune system might encounter. They have a long memory like B-cells.   [10:09] The overlap in these two threads of research was regarding a population of T cells that are important for mediating chronic inflammation at epithelial sites, including the gut.   [10:36] These T cells have been described in the airways in asthma, in the skin in eczema, and the GI tract. Researchers years ago had also described them as being associated with IgE food allergy. People with IgE food allergies avoid allergens.   [11:13] T cells, being associated with chronic allergic inflammation, now being associated with food allergies which are not having chronic exposures to the allergen, was interesting and surprising.   [11:30] Dr. Shreffler and his group found the T cell subset in patients who don't do well with Oral Immunotherapy (OIT) and patients who have EoE with immediate symptoms.   [12:01] Dr. Shreffler notes differences. There are immediate symptoms of IgE food allergy. There is a subset of patients with EoE who have immediate symptoms that are not fully understood. Maybe IgE plays a role there.   [12:28] There are different mechanisms for how symptoms are caused and so different ways of making a diagnosis. A food allergy with an IgE antibody can be measured through skin tests and blood tests. This can help identify which foods are the trigger.   [12:57] This common T cell subset that we see in EoE and food allergy, helps to explain why IgE alone is not always a very specific marker for identifying people who will have immediate reactions when they're exposed to the food.   [13:17] For patients who react at low levels, it's not just that they have more or better IgE but they also have an expansion of these T cells that are common between EoE and other chronic forms of allergy and IgE food allergy.   [13:41] There's a lot to learn that might be relevant for patients about this T cell subset.   [14:23] These T cells are a specific subset of the group of Th2 T cells, which are a subset of all CD4 T cells. Some CD4 T cells are important for responding to viruses and tumors. Others are important for responding to outside allergens.   [15:01] In an allergy or a parasite infection, Th2 T cells are important. There is a subset of T cells that is driven by repetitive and chronic exposure to the triggering protein, antigen, or allergen.   [15:47] Most antigens are proteins that trigger an immune response. An antigen that elicits an allergic response is an allergen. [16:30] A food trigger is a protein antigen that is an allergen. In IgE, food allergies, milk, and eggs are prevalent triggers early in life. For reasons not well understood, a lot of people outgrow them. In older patients, peanut and tree nut allergies are prevalent.   [17:01] In EoE, milk is one of the most common dietary triggers into adulthood. Some patients with IgE allergy to milk can tolerate it if it's well cooked. Patients with EoE are less likely to be able to get away with regular and ongoing exposure to milk protein.   [17:54] Milk, eggs, and nuts are common triggers in both conditions. There can also be rare food allergy triggers. That's part of the early evidence that the adaptive immune response was likely to be involved. It can be so specific for some people to rare things.   [18:20] Hallmarks of something being immune-mediated are that it is reproducibly demonstrable as a trigger. It's going to be long-lived. It's going to be generally relatively small amounts. The immune system is good at detecting small exposures.   [19:07] EoE is tricky because there's not that clear and easy temporal association between an offending allergen exposure for most people and their symptoms. People don't associate the symptoms with the triggers.   [20:14] A history of having blood in the stools can be milk-allergen-driven and was associated with a diagnosis of EoE in those kids when they're older.   [20:26] There are a lot of commonalities in the allergens but it's not always obvious clinically.   [22:40] A challenge in diagnosing EoE is that providers have to be on guard against their biases. They have to give a patient good advice. In EoE there is no test to identify triggers, except rigorous introduction, elimination, reintroduction, and endoscopies.   [24:18] For some of Dr, Shreffler's patients, it becomes less important to know their dietary triggers. They gravitate toward an approved form of treatment that may, if successful, allow them to have a more normal diet because of effective medication.   [24:50] Dr. Shreffler thinks there are other triggers, including pollens. There is evidence of seasonality of active EoE in patients shown to have allergic sensitization to pollens. That's indirect evidence. If the body is making IgE, it's likely making other responses.   [25:32] There are questions about how large the population of patients is who have EoE that may be more intrinsically than extrinsically driven because of genetic variations.   [25:54] Dr. Shreffler believes that EoE in some patients is allergen-driven and in some patients EoE is food-driven. Food is a trigger for the majority of pediatric patients and a large percentage of adult patients but not necessarily the exclusive trigger.   [27:04] If a patient is motivated to learn what dietary triggers may be at play, Dr. Shreffler often makes assessments outside of pollen season for allergens to which the patient has demonstrated positivity.   [28:09] Looking at the epidemiology, both EoE and food allergy are atopic disorders. You see an increased prevalence of asthma, hay fever, eczema, and even allergic proctocolitis in infancy. You see an enrichment of one disorder to another.   [28:29] The overlap of food allergy to EoE is stronger than you might expect. About 30 to 40% of patients with EoE will also have IgE food allergy. A higher rate will have IgE positivity, whether or not that food is a trigger of immediate symptoms.   [28:48] Patients with food allergies are about four times more likely to have EoE than the general population. That's a stronger association than the risk of eczema or other atopic conditions to EoE.   [30:09] There are differences between IgE food allergy and EoE. The presence of IgE gives a useful tool for identifying the food trigger in food allergy, but not in EoE. Identifying rare triggers in EoE patients is done by clinical observation.   [31:46] Epinephrine and antihistamines are not useful in treating EoE. Blocking IgE with Omalizumab has not been effective in trials in treating EoE. PPIs, topical steroids, and dupilumab are helpful for many EoE patients.   [32:38] Dupilumab has been evaluated a bit in food allergy in combination with OIT, and there was no statistically significant benefit from dupilumab in food allergy.   [33:25] A group in Pennsylvania has been evaluating epicutaneous immunotherapy as a modality to treat EoE. It's also being evaluated for IgE food allergy. Dr. Shreffler thinks it's something to keep an eye on.   [33:40] The oral route for immunotherapy can drive EoE for patients. As they become less sensitive from an immediate reactivity viewpoint, a significant percentage of patients develop GI symptoms. This has also been observed with sublingual therapy.   [34:14] Iatrogenic EoE, caused by the treatment, may resolve on the cessation of the immunotherapy treatment.   [36:25] Dr. Shreffler says in some cases, the shared decision is a decision where he has a strong evidence-based opinion. In some cases, there's a lot more room for a range of clinical decisions that could be equally supported by what we know right now.   [36:57] We've said that EoE is a contraindication for OIT. There is a shift happening. Dr. Shreffler sits with families and has a conversation about restricting diet or trying chronic therapy and keeping an ad-lib diet.   [37:38] What about doing the same thing by treating the immediate-type food allergy with chronic allergen exposure and then ameliorating the effects of EoE if it emerges, with another therapy? A hundred providers would have a diversity of responses.   [38:19] When there is a history of EoE in a family, Dr. Shreffler advocates for getting a baseline scope. It becomes an important “ground zero.”   [38:28] The goal is to have less invasive ways to monitor these conditions.   [39:32] Chronic inflammation, which is the hallmark of EoE, is well-targeted by therapies like PPIs and steroids. Steroids don't help with IgE-related food allergies. They're not effective at blocking the IgE-driven immediate response.   [41:13] Until recently, IgE food allergy has only been managed with avoidance. We have some other tools now. Xolair is not effective in EoE but is effective in two-thirds to three-quarters of patients with immediate-type food allergies for preventing anaphylaxis.   [41:45] Dr. Shreffler refers to an upcoming study on the effectiveness of Xolair in treating people with food allergies. Those who were able to tolerate a minimum amount were allowed to begin consuming allergen. We'll get insight into how those patients did.   [43:08] Food-induced immediate response of the esophagus (FIRE) is immediate discomfort with exposure to some allergens. Dr. Shreffler explains it. Data supports that these patients are experiencing an IgE-mediated but local response to those triggers.   [44:59] If FIRE is IgE-mediated, it may be that Xolair would help suppress it in these patients. It's worth looking at Xolair for this subset of EoE patients.   [45:20] Ryan invites any listeners who want to learn more about FIRE to check out episode #34 with Dr. Nirmala Gonsalvez.   [45:37] In the paper, Dr. Shreffler wrote about what he hopes will be the practical usefulness of the finding, the intersection between IgE food allergy and EoE.   [45:56] A subset of Th2 T cells express a protein called GPR15. It appears to be a marker for the subset of cells that are playing a role in the EoE.   [46:36] Caitlin Burk's work now is looking at their activation status in active disease and post-diet elimination and remission. She is developing a data set that is leading us toward the possibility of focusing on that cell subset and techniques to adopt in clinics.   [47:12] She is also working out more advanced techniques to look at the receptors. Dr. David Hill at CHOP is working on similar research. This research has the potential to lead to the development of better tests for EoE.   [47:44] Holly tells Dr. Shreffler this has been such an informative episode with so many tidbits of things to help patients advocate for themselves. Holly thanks him for sharing all of that.   [48:12] Dr. Shreffler is trying to see what can be utilized from their research to make non-invasive tests to identify food allergen triggers for patients so they don't have to go through so many endoscopies. He sees it as a huge unmet need.   [48:31] Ryan thanks Dr. Shreffler for joining us. For our listeners who would like to learn more about eosinophilic disorders, including EoE, please visit APFED.org and check out the links in the show notes.   [48:41] If you're looking to find a specialist who treats eosinophilic disorders, we encourage you to use APFED's Specialist Finder at APFED.org/specialist.   [48:50] If you'd like to connect with others impacted by eosinophilic diseases, please join APFED's online community on the Inspire Network at APFED.org/connections.   [49:00] Ryan thanks Dr. Shreffler for joining us today for this interesting conversation. Holly also thanks APFED's Education Partners Bristol Myers Squibb, GSK, Sanofi, and Regeneron for supporting this episode.   Mentioned in This Episode: Dr. Wayne Shreffler, MD, Ph.D., Chief of Pediatric Allergy and Immunology and Co-Director of The Food Allergy Center at Massachusetts General Hospital “Triggers for eosinophilic esophagitis (EoE): The intersection of food allergy and EoE” Dr. Caitlin Burk Dr. David A. Hill   APFED on YouTube, Twitter, Facebook, Pinterest, Instagram Real Talk: Eosinophilic Diseases Podcast apfed.org/specialist apfed.org/connections   Education Partners: This episode of APFED's podcast is brought to you thanks to the support of Bristol Myers Squibb, GSK, Sanofi, and Regeneron.   Tweetables:   “This fascinating problem of food allergy: why does the immune system do that for some people — recognize what should be nutritive and innocuous sources of energy as an immunological trigger? ” — Dr. Wayne Shreffler   “A food allergy; because there is this IgE antibody, we can do skin tests. We can measure that in the blood. It's a useful marker for helping to identify which foods are the trigger.” — Dr. Wayne Shreffler   “EoE is tricky because there's not that clear and easy temporal association between an offending allergen exposure for most people and their symptoms. People don't associate the symptoms with the triggers.” — Dr. Wayne Shreffler   “Everything is shared decision-making. In some cases, it's a shared decision where I have a strong evidence-based opinion. In some cases, there's a lot more room for a range of clinical decisions that could be equally justified.” — Dr. Wayne Shreffler   “Steroids don't help with IgE-related food allergy. They're not effective at blocking that IgE-driven immediate response.” — Dr. Wayne Shreffler   “I'm trying to see what we can utilize from our research to make non-invasive tests to identify food allergen triggers for patients so they don't have to go through so many endoscopies. I think that's a huge unmet need.” — Dr. Wayne Shreffler  

YouTube - https://youtu.be/lzNbyvjkMZ4 Criminal Defence LawyersJoseph Neuberger, and YouTube personality, legal researcher and host of the UnTrue Crime podcast Diana Davison, sit down and discuss the aftermath of their trials and the emerging and alarming changes to our legal system. A behind the scenes inside look into real courtroom drama. Website: http://www.NotOnRecordpodcast.com Sign up to our email list - http://eepurl.com/hw3g99 Social Media Links Twitter: http://www.twitter.com/NotonRecord Instagram: https://www.instagram.com/notonrecordpodcast/ TikTok: https://www.tiktok.com/@notonrecordpodcast Facebook: https://www.facebook.com/notonrecord Telegram: https://t.me/NotOnRecord Minds: http://www.minds.com/notonrecord Audio Platforms Spotify: https://open.spotify.com/show/4F2ssnX7ktfGH8OzH4QsuX Apple Podcasts: https://podcasts.apple.com/us/podcast/not-on-record-podcast/id1565405753 SoundCloud: https://soundcloud.com/notonrecord Rumble: https://rumble.com/c/c-842207 For more information on criminal law issues go to Neuberger & Partners LLP http://www.nrlawyers.com. Produced by Possibly Correct Media www.PossiblyCorrect.com

Dr. Antonio Jimenez discusses the innovative treatments and holistic approach at Hope4Cancer Treatment Centers. Learn about the comprehensive strategies used to combat cancer and support healing. #CancerTreatment #HolisticHealth #Hope4Cancer

Angela welcomes gut health expert, Josh Dech, who explores the profound connection between gut health and mental well-being. Together they delve into the intricate relationship between the brain and gut, discussing how neurotransmitters produced in the gut influence mood and behaviour, emphasising the importance of diet, and highlighting the need for whole foods, the avoidance of intolerances, and the impact of histamines, particularly for those with conditions like Crohn's disease. KEY TAKEAWAYS The gut and brain are intricately connected, with a significant portion of neurotransmitters, such as serotonin, being produced in the gut. This connection influences mental health, behaviour, and overall well-being. Symptoms like bloating, constipation, and acid reflux can indicate underlying gut issues. It's essential to listen to these symptoms as they can provide insights into one's overall health and potential imbalances in the gut microbiome. A diet rich in whole foods, tailored to individual tolerances, is crucial for maintaining gut health. Avoiding high-histamine foods is particularly important for those with conditions like Crohn's disease or colitis. While testing the gut microbiome can provide valuable information, symptoms should be the primary focus for assessing gut health. An organic acid test is recommended for a comprehensive view of overall health. BEST MOMENTS "If the factory that's producing these chemicals is on fire, you're not going to have the end result you're looking for." "I think everything comes from the gut until proven otherwise." "The irony is we go in with these antacids or proton pump inhibitors, and what do we do? We suppress it even further." "It's no wonder that 60% of all North American adults have some kind of diagnosed chronic condition." "If you have gut dysbiosis, an imbalance in your gut bacteria, you're going to end up with neuroinflammation, irritation, imbalanced brain chemistry." VALUABLE RESOURCES Get a free snapshot of your health and personalised report at www.yourtotalhealthcheck.com Join The High Performance Health Community A BIG thank you to our sponsors who make the show possible: Target 9 out of the 12 Hallmarks of Aging with Oxford Healthspan Primeadine – CLICK HERE and use code ANGELA to save 15% Boost your NAD+ and transform your energy & vitality for a younger you with Qualia NAD+ - www.qualiife.com/angela and use code ANGELA for 15% off ABOUT THE GUEST Josh is a Holistic Nutritionist and Physician’s consultant, specializing in Crohn’s, Colitis, and severe IBS. After reversing over 300 cases of Crohn’s and colitis (previously thought to be impossible to fix), he’s been connected to some of the world’s most renowned doctors.He’s since launched a top 2.5% globally ranked podcast, and has been recruited to the Priority Health Academy as a medical lecturer, helping educate doctors on the holisticapproach to gut health, and inflammatory bowel disease. https://gutsolution.ca/ ABOUT THE HOST Angela Foster is an award winning Nutritionist, Health & Performance Coach, Speaker and Host of the High Performance Health podcast. A former Corporate lawyer turned industry leader in biohacking and health optimisation for women, Angela has been featured in various media including Huff Post, Runners world, The Health Optimisation Summit, BrainTap, The Women’s Biohacking Conference, Livestrong & Natural Health Magazine. Angela is the creator of BioSyncing®️ a blueprint for ambitious entrepreneurial women to biohack their health so they can 10X how they show up in their business and their family without burning out. The High Performance Health Podcast is a top rated global podcast. Each week, Angela brings you a new insight, biohack or high performance habit to help you unlock optimal health, longevity and higher performance. Hit the follow button to make sure you get notified each time Angela releases a new episode. CONTACT DETAILS Instagram Facebook LinkedIn Affiliate Disclaimer: Note this description contains affiliate links that allow you to find the items mentioned in this video and support the channel at no cost to you. While this channel may earn minimal sums when the viewer uses the links, the viewer is under no obligation to use these links. Thank you for supporting the show! Disclaimer: The High Performance Health Podcast is for general information purposes only and do not constitute the practice of professional or coaching advice and no client relationship is formed. The use of information on this podcast, or materials linked from this podcast is at the user's own risk. The content of this podcast is not intended to be a substitute for medical or other professional advice, diagnosis, or treatment. Users should seek the assistance of their medical doctor or other health care professional for before taking any steps to implement any of the items discussed in this podcast.

Can personalized medicine unlock the secrets to living longer and healthier lives? In this episode of Longevity by Design, host Dr. Gil Blander sits down with Dr. David Barzilai, a renowned longevity physician and founder of Barzilai Longevity Consulting, to explore the science of extending healthspan through precision and innovation.Dr. Barzilai shares his journey into biogerontology and longevity science, unpacking key concepts like the hallmarks of aging, the potential of lifestyle interventions, and the translation of findings from animal models to human health. He highlights how evidence-based lifestyle medicine—centered on nutrition, exercise, sleep, and stress management—can be tailored to individual needs using biomarker-driven strategies for maximum impact.The conversation delves into some of the most promising longevity interventions, from gerotherapeutics to cutting-edge supplements. Dr. Barzilai emphasizes the power of personalized approaches in optimizing healthspan and lifespan, offering listeners practical, science-backed insights to take charge of their longevity journey.Engaging and informative, this episode is essential listening for anyone curious about the future of longevity medicine and the innovations shaping how we age. Guest-at-a-Glance

Look Younger, Live Longer with Dr. Michael Aziz Today, we're delving into the intriguing world of anti-aging with our esteemed guest, Dr. Michael Aziz, as we explore his groundbreaking book, The Ageless Revolution: 10 Hallmarks of Aging that Hold the Secret to Defeating Disease, Reversing Age, Looking Younger, and Living Longer.  Dr. Aziz brings an innovative perspective to understanding aging as a treatable disease, focusing on the cellular level. In this engaging discussion, we'll learn about the hallmarks of aging and how lifestyle changes can play a crucial role in promoting longevity. From the importance of gut health to the power of reducing inflammation, Dr. Aziz provides practical, actionable advice to help us all look and feel our best no matter our age. So, if you're ready to unlock the secrets to a healthier, fitter, and more energetic you, stay tuned for this interesting conversation on the 40+ Fitness Podcast!   Timestamps: 00:00 "Ageless Revolution: Defeating Aging" 04:55 "Introducing Dr. Michael Aziz" 09:47 "Basics Before Cryotherapy" 12:06 Understanding the Hallmarks of Aging 14:03 "Impact of Diet on Gut Health" 20:14 Inflammaging: Aging Cells Cause Disruption 21:11 "Skipping Meals for Cell Renewal" 24:51 "Sleep: Key to Aging Well" 29:38 Treat Aging as a Disease 31:20 "Accessible Health Improvement Guide" Get the book: The Ageless Revolution: 10 Hallmarks of Aging that Hold the Secret to Defeating Disease, Reversing Age, Looking Younger, and Living Longer - https://amzn.to/42NRU4x. https://michaelazizmd.com https://40plusfitness.com

Jon Haley

Subscribe to our channel: https://www.youtube.com/@optispan In this video I sit down with Dr. Peter Attia to explore strategies for improving healthspan and lifespan, focusing on practical interventions like exercise, nutrition, and emerging therapies. Topics we discuss include defining healthspan (physical, cognitive, and emotional health), the benefits of purposeful exercise, and prioritizing dietary factors (what, when, and how much to eat). Our discussion also addresses nuanced views on processed foods, alcohol, and the limitations of trendy approaches like epigenetic clocks. Other topics discussed are interventions such as hormone therapy, rapamycin, metformin, and NAD boosters, offering insights into their potential benefits and current limitations. Experimental therapies like stem cells, peptides, and hyperbaric oxygen are highlighted, emphasizing the importance of evidence-based practices. 0:00 - Introduction: Healthspan vs. Lifespan 3:51 - Exercise for Healthspan and Longevity 7:51 - Nutrition Priorities for Longevity 15:56 - Alcohol: Risks, Benefits, and Nuances 27:10 - Epigenetic Clocks and Biological Age Testing 37:08 - APOE Status and Cognitive Risk 41:25 - STEM Cells & Emerging Experimental Therapies 50:28 - Matt's Lightning Round Questions 1:12:47 - The Hallmarks of Aging Game 1:15:20 - Bonus Question Producers: Tara Mei, Nicholas Arapis Video Editor: Jacob Keliikoa DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices. More places to find us: Twitter: https://twitter.com/optispanpodcast Twitter: https://twitter.com/optispan Twitter: https://twitter.com/mkaeberlein Linkedin: https://www.linkedin.com/company/optispan Instagram: https://www.instagram.com/optispanpodcast/ TikTok: https://www.tiktok.com/@optispan https://www.optispan.life/ Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it. On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

Carlos Campos

This episode is a part of a new segment of the Mutuality Matters podcast, hosted by Tara and Todd Korpi. In this segment we discuss headship theology––dynamics of power, authority, and gender, and how they function in Christian homes, the local church and society. In this special two-part interview, we're joined by Zachary C. Wagner, director of programs for the Center for Pastor Theologians and author of Non-Toxic Masculinity, to discuss the role unhelpful views of masculinity impact how women and men function together.    Guest Bio  Zachary Wagner is a writer, researcher, and ordained minister––thinker of thoughts and feeler of feelings who lives in Chicagoland. He is pursuing a DPhil (PhD) in New Testament studies at Keble College, University of Oxford. He also serves as the director of Programs for the Center for Pastor Theologians, where he co-hosts the CPT Podcast. His research interests include economics in the ancient world, divine wages in Second Temple Judaism and early Christianity, Pauline epistles, the Gospel of Matthew, and New Testament masculinities. His first book, Non-Toxic Masculinity: Recovering Healthy Male Sexuality, was published in 2023 with Intervarsity Press. Zach's other writing interests include evangelical and “post-vangelical” Christian discipleship, theological formation, and speaking against church-based abuse.  Buy Zachary's book, Non-Toxic Masculinity  Follow Zachary on Instagram and X  Read “Broken Masculinity” on the Center for Pastor Theologians      Related Resources  New Voices: Non-Toxic Masculinity with Zachary Wagner  Jesus' Vision for Masculinity: The (Actual) Best A Man Can Get  My Kingdom for A World of Such Men: 3 Hallmarks of Healthy Masculinity    Disclaimer  The opinions expressed in CBE's Mutuality Matters' podcast are those of its hosts or guests and do not purport to reflect the opinions or views of CBE International or its members or chapters worldwide. The designations employed in this podcast and the presentation of content therein do not imply the expression of any opinion whatsoever on the part of CBE concerning the legal status of any country, area or territory or of its authorities, or concerning the delimitation of its frontiers. 

Nathan Parikh

Dr. Antonio Jimenez discusses the innovative treatments and holistic approach at Hope4Cancer Treatment Centers. Learn about the comprehensive strategies used to combat cancer and support healing. #CancerTreatment #HolisticHealth #Hope4Cancer

Ready to make 2025 your healthiest year yet? Today's #WisdomWednesday uncovers the 12 scientific hallmarks of ageing that affect your health, energy, and longevity. Find out how your cells' 'powerhouses' and 'zombie cells' impact your ageing process, and learn why the next 12 weeks of episodes will revolutionise your approach to healthy ageing. Your journey to understanding - and slowing down - the ageing process starts here.See omnystudio.com/listener for privacy information.

Jon Haley

In this episode, CJ interviews Ross Grainger, the CFO of Paradox, to discuss work-life integration (instead of balance), why the corporate ladder is less like a ladder and more like a jungle gym, and the hallmarks of a great CFO/FP&A/controller relationship. He starts by sharing his own unconventional career journey and talks about the importance of the hustle, giving examples from his own life of periods when things were weighted towards life or work and how this benefited him. He also describes why the career ladder is more like a jungle gym and gives examples of times when he had to step backwards or sideways to get ahead. He sheds light on the value of investing in work relationships outside of finance, such as product marketing and sales, before discussing the hallmarks of a good CFO/controller/FP&A relationship. With a team in Vietnam, he gives advice on how to expand internationally. The episode includes an explanation of why Ross doesn't believe in annual planning, what he does instead, and how he justifies this to the board. If you're looking for an ERP head to NetSuite: https://netsuite.com/metrics and get a customized KPI checklist.—SPONSORS:Operators Guild is where the best CEOs, CFOs, VPs of finance, and BizOps leaders in the business connect, network, and grow together. Built by operators for operators, this members-only community is home to more than 1000 of the most elite high-growth operators in the world. Experience connection and knowledge share with professionals who understand you like no one else does. Learn more and apply at operators-guild.com. Maxio is the only billing and financial operations platform that was purpose built for B2B SaaS. They're helping SaaS finance teams automate billing and revenue recognition, manage collections and payments, and put together investor grade reporting packages.

Angela explores the vital topic of longevity with insights from notable past guests, including Julie Gibson-Clark, Liz Earle and Dr. Andrew Steele, author of "Ageless." Featuring highlights from their past conversations, Angela delves into practical strategies for enhancing health and vitality, such as incorporating a pound of vegetables into daily nutrition and the importance of foundational health habits like exercise, nutrition, and sleep KEY TAKEAWAYS Cellular Health and Anti-Aging Biohacks: Liz Earle and Andrew Steele discuss the science of cellular senescence, mitochondrial function, and the importance of supplements like NAD+ and collagen to maintain youthful vitality. Practical Longevity Tips: Julie Gibson Clark shares easy, budget-friendly approaches to integrating healthy habits, including eating a pound of vegetables daily and consistent exercise. The Power of Foundational Habits: Dr. Andrew Steele highlights the critical role of sleep, exercise, and nutrition in actively slowing biological aging and preparing to benefit from future medical innovations. Women-Centric Biohacking: Liz Earle emphasises biohacks tailored for women, from grounding exercises to adaptogens like ashwagandha, highlighting how these habits support midlife health and glowing skin. TIMESTAMPS AND KEY TOPICS 0:05 - Liz Earle: Cellular health and senescence.0:49 - Angela Foster: Introduction to longevity and biohacks.4:08 - Julie Gibson Clark: Practical tips for eating more vegetables.15:02 - Julie Gibson Clark: Stress management and meditation routines.26:00 - Dr. Andrew Steele: Advancements in anti-aging science.35:56 - Hallmarks of aging explained.47:03 - Liz Earle: Women's biohacks and morning routines.52:11 - Liz Earle: Supplements for longevity.59:24 - Liz Earle: Skincare inside-out approach.1:06:14 - Angela Foster: Closing thoughts and actionable advice. VALUABLE RESOURCES Get a free snapshot of your health and personalised report at www.yourtotalhealthcheck.com Join The High Performance Health Community Visit Just Thrive and use CODE ANGELA20 at www.justthrivehealth.com Julie Gibson Clark Episode - https://omny.fm/shows/high-performance-health/reverse-aging-on-a-budget-the-simple-practices-a-s Liz Earle Episode - https://omny.fm/shows/high-performance-health/a-better-second-half-how-to-live-a-longer-healthie Andrew Steele Episode - https://omny.fm/shows/high-performance-health/the-science-of-staying-young-dr-andrew-steele-on-r CONTACT DETAILS Instagram Facebook LinkedIn Affiliate Disclaimer: Note this description contains affiliate links that allow you to find the items mentioned in this video and support the channel at no cost to you. While this channel may earn minimal sums when the viewer uses the links, the viewer is under no obligation to use these links. Thank you for supporting the show! Disclaimer: The High Performance Health Podcast is for general information purposes only and do not constitute the practice of professional or coaching advice and no client relationship is formed. The use of information on this podcast, or materials linked from this podcast is at the user's own risk. The content of this podcast is not intended to be a substitute for medical or other professional advice, diagnosis, or treatment. Users should seek the assistance of their medical doctor or other health care professional for before taking any steps to implement any of the items discussed in this podcast.

DJ Brian Foss (and his wife/DJ assistant Cyndi) deliver a fun holiday edition of In Our Headphones, featuring everything from pop to soul to psych. Brian is KEXP’s longtime Christmas guy, having hosted the “Punk Rock X-Mess” for over 20 years on the punk show Sonic Reducer, and hosting “No Standards Christmas” on December 25th for over a decade. Music Director Chris Sanley closes out this Christmas episode with a melancholy track for the season. Thanks Light - “Dirtbag Christmas” Toddy - “Hold On Holly (I Want Your Mom)” DeRobert & The Half-Truths - “Peace on Earth” The Hallmarks - “Soul Shakin' Psychedelic Santa” Madi Diaz - “Kid on Christmas” Listen to the full songs on KEXP's "In Our Headphones 2024" playlist on Spotify or the “What's In Our Headphones” playlist on YouTube. Hosted and produced by: Janice Headley and Isabel KhaliliMixed by: Emily FoxMastered by: William MyersEditorial Director: Larry Mizell Jr. Our theme music is “好吗 (Hao Ma)” by Chinese American Bear Support the show at: kexp.org/headphonesContact us at headphones@kexp.orgSupport the show: https://www.kexp.org/donateSee omnystudio.com/listener for privacy information.

“Mitochondrial health is key to whole body health,” says Anurag Singh, M.D., Ph.D.   Singh, Chief Medical Officer at Timeline Nutrition and doctor of internal medicine, joins us to dive deep into the importance of mitochondrial health, the power of Urolithin A, and the impact of lifestyle, plus:  - What is mitochondrial dysfunction (~1:55) - Lifestyle factors impacting mitochondrial health (~3:35) - Exercise & fasting (~5:20) - Autophagy vs mitophagy (~6:18) - Environmental factors & mitochondrial health (~8:35) - Diet & nutrients (~9:40) - Urolithin A (~11:45) - Muscle health & Urolithin A (~17:55) - Recovery and resilience (~23:15) - Inflammation & Urolithin A (~28:55) - The future of mitochondrial research (~30:30) - Brain health & mitochondria (~34:50) - How to test mitochondrial health (~37:30) - Singh's take home message (~40:35) Referenced in the episode:  - Follow Singh on LinkedIn (linkedin.com/in/asingh041)  - Check out Timeline Nutrition (https://www.timeline.com/)  - Learn more about his research (https://www.researchgate.net/profile/Anurag-Singh-89)  - Hallmarks of Aging (DOI: 10.1016/j.cell.2022.11.001)  With Timeline's clinically tested, doctor-recommended supplements you'll see improvements in cellular energy, muscle strength, and endurance.* For listeners of this podcast: Get 10% off your first order of 1, 2 or 4 month Timeline offers. Use code MBG10 at timeline.com/mbg. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. We hope you enjoy this episode, and feel free to watch the full video on YouTube! Whether it's an article or podcast, we want to know what we can do to help here at mindbodygreen. Let us know at: podcast@mindbodygreen.com. Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode, Dr. Jessica Steier and Dr. Sarah Scheinman discuss the complexities of cancer with Dr. Joe Zundell, a cancer biologist. They explore the definition of cancer, its prevalence, and the hallmarks that characterize cancer cells. The conversation delves into the mechanisms of cancer growth, including sustaining proliferative signaling, evading growth suppression through the P53 gene, and the process of apoptosis. The discussion aims to make these complex topics accessible to a broader audience while highlighting the importance of understanding cancer biology. In this conversation, Dr. Joe Zundell discusses the complexities of cancer biology, focusing on key hallmarks such as immune response, replicative immortality, angiogenesis, and metastasis. He emphasizes the importance of early detection and the challenges of targeting cancer cells without affecting healthy cells. The discussion highlights the need for careful consideration of information regarding cancer treatment and the significance of working with healthcare professionals. All our sources from this episode are available at: https://www.unbiasedscipod.com/episodes/ (00:00) Introduction  (05:28) Understanding Cancer: Definitions and Statistics (10:15) The Hallmarks of Cancer: An Overview (15:14) Sustaining Proliferative Signaling in Cancer (20:07) Evading Growth Suppression: The Role of P53 (25:17) Apoptosis: The Controlled Cell Death Mechanism (30:21) Understanding Cancer: Immune Response and Cell Death (33:31) Replicative Immortality: The Hayflick Limit (38:27) Angiogenesis: Blood Vessel Formation in Tumors (46:32) Invasion and Metastasis: The Spread of Cancer (54:22) Final Thoughts: The Complexity of Cancer Treatment and Early Detection Interested in advertising with us? Please reach out to advertising@airwavemedia.com, with “Unbiased Science” in the subject line. PLEASE NOTE: The discussion and information provided in this podcast are for general educational, scientific, and informational purposes only and are not intended as, and should not be treated as, medical or other professional advice for any particular individual or individuals. Every person and medical issue is different, and diagnosis and treatment requires consideration of specific facts often unique to the individual. As such, the information contained in this podcast should not be used as a substitute for consultation with and/or treatment by a doctor or other medical professional. If you are experiencing any medical issue or have any medical concern, you should consult with a doctor or other medical professional. Further, due to the inherent limitations of a podcast such as this as well as ongoing scientific developments, we do not guarantee the completeness or accuracy of the information or analysis provided in this podcast, although, of course we always endeavor to provide comprehensive information and analysis. In no event may Unbiased Science or any of the participants in this podcast be held liable to the listener or anyone else for any decision allegedly made or action allegedly taken or not taken allegedly in reliance on the discussion or information in this podcast or for any damages allegedly resulting from such reliance. The information provided herein do not represent the views of our employers. Learn more about your ad choices. Visit megaphone.fm/adchoices

While I've discussed longevity and aging in multiple episodes on this platform, I thought it was time for a deep dive and explain some of the nuanced details about aging and lifespan. We'll cover the primary theory of aging, the hallmarks of aging, the physiological process of AMPK and mTOR and their relationship, and much more! Topics include:   - Simplifying the Science of Aging - What We'll Cover Today - Primary Theory of Aging - The 9 Hallmarks of Aging - Stem Cell Therapy - Explaining DNA Further - Remember CD's? - 2 Pathways to Aging - Are Sacrifices and Tradeoffs Necessary? - AMPK and mTOR Relationship - Measuring Aging - Longevity Supplements ----------  My Live Program for Coaches: The Functional Nutrition and Metabolism Specialization  www.metabolismschool.com ----------  Subscribe to My Youtube Channel:  https://youtube.com/@sammillerscience?si=s1jcR6Im4GDHbw_1 ----------     [Free] Metabolism School 101: The Video Series http://www.metabolismschool.com/metabolism-101     ----------     Grab a Copy of My New Book - Metabolism Made Simple     ----------   Stay Connected:     Instagram: @sammillerscience     Youtube: SamMillerScience     Facebook: The Nutrition Coaching Collaborative Community     TikTok: @sammillerscience       ---------- “This Podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast and the show notes or the reliance on the information provided is to be done at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment and is for educational purposes only. Always consult your physician before beginning any exercise program and users should not disregard, or delay in obtaining, medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions. By accessing this Podcast, the listener acknowledges that the entire contents and design of this Podcast, are the property of Oracle Athletic Science LLC, or used by Oracle Athletic Science LLC with permission, and are protected under U.S. and international copyright and trademark laws. Except as otherwise provided herein, users of this Podcast may save and use information contained in the Podcast only for personal or other non-commercial, educational purposes. No other use, including, without limitation, reproduction, retransmission or editing, of this Podcast may be made without the prior written permission of Oracle Athletic Science LLC, which may be requested by contacting the Oracle Athletic Science LLC by email at team@sammillerscience.com. By accessing this Podcast, the listener acknowledges that Oracle Athletic Science LLC makes no warranty, guarantee, or representation as to the accuracy or sufficiency of the information featured in this Podcast."

It's gala season for Chris and Jessie. Chris is getting ready for his big night at Bette Midler's party. Jessie is getting ready for the season with the best tailor in town. Hallmarks make their triumphant return for a very spooky love story in honor of halloween. 

Today we have Dr. Rudolph E. Tanzi, who is perhaps best known for co-discovering all three familial early-onset Alzheimer's disease genes. In addition, Rudy's lab was the first to use human stem cells to create three-dimensional human brain organoids and three-dimensional neural-glial culture models of Alzheimer's disease, which became known as “Alzheimer's-in-a-Dish.” These models were the first to recapitulate all three of the key pathological hallmarks of Alzheimer's disease and have made drug screenings faster and cheaper. Rudy is the director of the Genetics and Aging Research Unit as well as the director of the Henry and Allison McCance Center for Brain Health. Rudy is also co-Director of the Massachusetts General Institute for Neurodegenerative Disease at Massachusetts General Hospital and serves as the Joseph P. and Rose F. Kennedy Professor of Neurology at Harvard Medical School. Rudy has published more than 700 research papers and is one of the top 50 most cited neuroscientists in the world. He is author of “Decoding Darkness,” and a co-author of two books with Deepak Chopra, “Super Brain” and “The Healing Self.” Show notes: [00:03:18] Ken opens the interview mentioning that Rudy began playing the accordion when he was just seven years old. Ken goes on to ask Rudy about the time his father gave him a Jimmy Smith album and some advice. [00:05:51] Ken mentions that, in addition to Rudy's musical talents, he was also interested in science growing up. Ken asks about Rudy's participation in the Westinghouse Science Talent Search and what that experience was like. [00:07:09] Ken asks Rudy about growing up in Cranston, Road Island. [00:08:39] Rudy talks about how he ended up at the University of Rochester after high school. [00:09:51] Ken mentions that both Rudy's grandfather and father passed away at the age of 45. Ken asks Rudy if this played a role in his pursuit of a career in genetics research. [00:10:57] Rudy explains how he chose Harvard Medical School for his Ph.D. [00:12:47] Ken pivots to ask Rudy about his time working with Jim Gusella in the early 80's at Mass General, where they were the first to ever find a disease gene. Family studies at the time had shown that the Huntington's disease gene was linked to a polymorphic DNA marker. Rudy talks about this discovery and how the chromosomal localization of the Huntington's disease gene was the first step in using recombinant DNA technology to identify the primary genetic defect in this disorder. [00:16:07] Ken asks Rudy about his work in 1987, when he discovered the first Alzheimer's gene, recombinant DNA technology, which causes the production of amyloid. Ken goes on to explain that mutations in the APP gene can cause a rare form of early onset Alzheimer's. Rudy talks about the paper that came out in “Science” that detailed this discovery. [00:18:38] Rudy discusses his personal philosophy and approach to research. [00:19:43] Ken mentions that in Rudy's book, Decoding Darkness, he writes that few nightmares on Earth can compare to Alzheimer's disease. Ken asks Rudy to talk more about this book. [00:21:50] Ken explains that in the same way our physical capabilities will suffer some form of decline with age, it is also expected that we have some decline in memory and cognitive ability as we age as well. However, Ken goes on to say that when people begin to experience age-related memory lapses, it can lead to a lot of anxiety about their genetic predisposition to Alzheimer's. Ken asks Rudy to talk about the lifestyle factors that play into whether someone predisposed to develop Alzheimer's can stave off or avoid disease development. [00:26:09] Ken explains that aging appears to intensify when people stop challenging themselves with new things. Given this, Ken asks Rudy what his thoughts are on challenging our brains as they age to protect our cognitive abilities. [00:29:08] Ken asks Rudy about the principal advances in...