Podcast appearances and mentions of David Perlmutter

In this episode, board-certified neurologist Dr. David Perlmutter, author of Brain Defenders, reveals how your brain's immune cells, the microglia, hold the key to preventing cognitive decline and neurodegenerative disease.For decades, neurodegenerative research has fixated on amyloid plaques and tau tangles, treating the downstream smoke while ignoring the raging metabolic fire beneath. In this comprehensive masterclass, Dr. Perlmutter reveals why the real driver of brain aging lies within microglia, the brain's resident immune defenders. Under healthy conditions, microglia nurture synapses and clear debris. But when triggered by elevated blood glucose, gut dysbiosis, environmental air toxins, or lack of deep sleep, they flip into an aggressive, destructive phenotype that destroys brain connections. Dr. Perlmutter shares practical, evidence-based protocols to keep your microglia in their protective state: why a fasting glucose above 90 mg/dL poses hidden risks, how muscle-derived myokines cross the blood-brain barrier, the truth about adult hippocampal neurogenesis, and the exact supplement stack (including DHA, Akkermansia, Urolithin A, DHM, and rosmarinic acid) supported by peer-reviewed science.

Neurologist David Perlmutter MD says the beta-amyloid theory of Alzheimer's is wrong — and the real culprit is your brain's own immune cells. In this episode of Health Longevity Secrets, Robert Lufkin MD sits down with the #1 New York Times bestselling author to unpack his new book Brain Defenders: how diet, blood sugar, and metabolic health flip the brain's microglia from protective to destructive, why anti-amyloid drugs offer "trivial" benefit, and which biomarkers actually predict your brain's future.Chapters:00:00 — Introduction01:38 — Why He Left Mainstream Neurology to Prevent Brain Decline05:24 — Building the World's Largest Integrative Neurology Practice06:55 — The Common Pathway From Metabolism to Brain Degeneration08:25 — Why the Beta-Amyloid Theory of Alzheimer's Is Wrong09:11 — What Are Microglia? The Brain's Immune Cells (M1 vs M2)12:13 — From Brain "Glue" to Master Regulators of Your Synapses16:00 — How Body Inflammation and Cytokines Reach the Brain18:15 — Leaky Gut, the Microbiome, and Brain Degeneration19:46 — Ultra-Processed Foods Raise Alzheimer's Risk Up to 270%25:02 — Synaptic Pruning: The Link Between Autism, ADHD and Alzheimer's29:36 — Why Diabetics Recover Worse From Head Trauma31:51 — Anti-Amyloid Drugs: "Trivial" Benefit, Serious Harm35:37 — The Biomarkers to Track: Fasting Glucose, Insulin, A1C40:09 — On the Horizon: Mitochondrial Therapies and Microglial Transplants45:26 — Glyphosate, Air Pollution and 40Hz Light Therapy47:00 — Brain Defenders Releases August 18 — Final TakeawaysKey takeaways:Alzheimer's is increasingly understood as a "synaptopathy" — a disease of lost synapses driven by the brain's own immune cells (microglia), not simply beta-amyloid plaque.Microglia shift from supportive (M2) to destructive (M1) in response to metabolic signals: high blood sugar, insulin resistance, elevated blood pressure, excess body fat, and inflammation.A long-term cohort found each daily serving of ultra-processed food raised Alzheimer's risk ~13%, with 10+ servings/day linked to a 2.7-fold (270%) increase.A Cochrane review of anti-amyloid antibodies found "trivial" cognitive benefit alongside meaningful harm, including brain swelling and microbleeds (ARIA).The most actionable brain biomarkers are cheap and accessible: fasting glucose, fasting insulin, A1c, waist circumference, and a continuous glucose monitor — aim for optimal, not just "normal."Emerging frontiers target the mitochondria inside microglia — metformin, CoQ10, urolithin A, exercise, fasting, ketones, and 40Hz gamma light therapy.Studies & sources:Weinstein et al., J Prev Alzheimers Dis — ultra-processed food and Alzheimer's riskCochrane Review (2026) — anti-amyloid monoclonal antibodies for Alzheimer'sIaccarino, Tsai et al. (Tsai Lab, MIT) — 40Hz gamma light and microgliaDr. Lufkin's book "Lies I Taught in Medical School": https://robertlufkinmd.com/lies/⭐ Enjoying the show? Please leave a 5-star review on Apple Podcasts — it takes 30 seconds and helps more people discover the science of health and longevity. Thank you!New episodes every other Tuesday. Subscribe so you don't miss one.Continue this conversation on Substack: https://robertlufkinmd.substack.comLies I Taught In Medical School — Free sample chapter: https://www.robertlufkinmd.com/lies/Web: https://www.robertlufkinmd.comYouTube: https://www.youtube.com/robertlufkinmdX: https://x.com/robertlufkinmdInstagram: https://www.instagram.com/robertlufkinmd/TikTok: https://www.tiktok.com/@robertlufkinLinkedIn: https://www.linkedin.com/in/robertlufkinmd/

Your brain is remarkably resilient—but modern life doesn't always make protecting it easy. In Brain Defenders, neurologist David Perlmutter explains how the brain's immune cells can either preserve cognitive health or contribute to decline—and how everyday choices can influence that balance. Then, in Rewired, psychiatrist and neuroscientist Carl Marci explores what smartphones, social media, and nonstop stimulation are doing to our attention, relationships, and emotional well-being.

What if Alzheimer's doesn't begin when you start forgetting names or struggling with memory but decades earlier, when subtle changes are happening in your metabolism, inflammation, and brain?   With Alzheimer's in my own family, this conversation with Dr. David Perlmutter felt especially personal. Dr. Perlmutter is a board-certified neurologist, six-time New York Times bestselling author, and one of the leading voices challenging how we think about brain health and cognitive decline. His new book, Brain Defenders, explores emerging research around microglia — the immune cells of the brain — and why they may hold an important key to protecting our brains as we age.   We dive into why Dr. Perlmutter believes we need to start thinking about Alzheimer's prevention in our 30s and 40s, the surprising connection between metabolic health and the brain, and how our everyday choices may influence whether our brain's immune cells protect us or work against us. We also get into the role of ultra-processed foods, blood sugar and insulin, the gut microbiome, environmental toxins, sleep, inflammation, mitochondria, vitamin D, and some of the biomarkers Dr. Perlmutter believes are worth knowing. And for women, we explore what happens to the brain during menopause, the latest conversation around estrogen and hormone replacement therapy, and why women face a greater risk of Alzheimer's.   Dr. Perlmutter also shares fascinating new research that could change how we think about Alzheimer's, Parkinson's, MS, traumatic brain injury, and other neurological conditions — including why the future of brain health may look very different from the traditional “wait for symptoms, then treat” approach. This episode left me feeling incredibly hopeful about how much influence we may actually have over the future of our brains. If you've ever worried about your memory, your family history, or simply want to stay sharp and resilient as you age, this is a conversation you don't want to miss. Key Moments You'll Love ✨ :

What if the health of your brain decades from now is being shaped by what you are doing today? We tend to think about Alzheimer's and cognitive decline as problems that show up later in life, once memory starts slipping or confusion becomes noticeable. But many of the factors associated with brain decline can begin much earlier. Blood sugar, insulin resistance, sleep, inflammation, muscle mass, exercise, social connection, oral health, and even the medications you regularly take may all influence the environment your brain is aging in. This matters because brain health gives you more areas to act on than most people realize. You can pay attention to metabolic markers before they become major problems, build and preserve muscle, protect your sleep, stay socially connected, take care of your oral microbiome, and understand which emerging therapies actually have evidence behind them. The earlier you start thinking about your brain this way, the more opportunity you have to influence how well it functions later. Dr. David Perlmutter is a board-certified neurologist, six-time New York Times bestselling author, and internationally recognized expert in brain health, nutrition, and neurodegenerative disease. His latest book, Brain Defenders, explores microglia, the brain's immune cells, and how their function may influence conditions including Alzheimer's and Parkinson's. His work focuses on giving people practical ways to protect brain health through metabolism, lifestyle, and emerging neuroscience. What's Discussed: (05:51) What research suggests about slowing or even improving cognitive decline in people already diagnosed with Alzheimer's through intensive lifestyle intervention. (10:47) Why Alzheimer's should not be viewed as purely genetic and how lifestyle and metabolic health can influence risk even when genetic predispositions are present. (12:19) How loneliness and social isolation may affect brain health through stress, cortisol, oxytocin, inflammation, and changes in the brain's immune cells. (20:50) Why the biological conditions associated with cognitive decline may begin in your 40s and 50s, decades before memory problems become obvious. (30:34) How exercise supports the brain through BDNF, irisin, and other chemicals released during muscle activity, and why both cardio and strength training matter. (38:00) Why restorative sleep is an active period for memory consolidation and brain recovery, and how fragmented sleep can undermine brain health even when you spend eight hours in bed. (1:04:34) What the science currently says about NAD, NR, NMN, and IV NAD for mitochondrial function, biological aging, and cognitive health. (1:12:04) How periodontal disease, the oral microbiome, and frequent use of certain antibacterial mouthwashes may affect nitric oxide, metabolism, and long-term brain health. (1:23:05) What emerging research says about GLP-1 drugs for Parkinson's and Alzheimer's, and why using or microdosing them specifically for brain protection is still ahead of the evidence. (1:33:25) Why homocysteine and fasting insulin are two blood markers worth paying attention to when assessing metabolic and long-term brain health.   Thank You to Our Sponsors! Magic Mind: Head over to magicmind.com/jen and use code JEN at checkout. Momentous: Ready to try supplements that actually do what they claim? Head to livemomentous.com and use code JEN for 35% off your first subscription.  Therasage: Visit therasage.com and use code JEN to get 15% off your order. Your skin Prolon: Prolon is offering listeners 30% off sitewide plus a $40 bonus gift when you subscribe to their 5-Day Program! Just visit prolonlife.com/JENNIFERCOHEN and use code JENNIFERCOHEN to claim your discount and your bonus gift. Tru Niagen®: For supplements that are rigorously tested, third-party verified, and actually deliver what's on the label, head to truniagen.com Find more from Jen Cohen: Website: jennifercohen.com Instagram: @therealjencohen Books: jennifercohen.com/books Speaking: jennifercohen.com/speaking-engagements   Find more from Dr. David Perlmutter: Website: drperlmutter.com Instagram: @davidperlmutter Facebook: David Perlmutter M.D.  YouTube: @davidperlmutterMD LinkedIn: David Perlmutte, MD Book: Brain Defenders  

If you've ever wondered whether your daily habits are quietly protecting your brain, or quietly working against it, this one's for you. Some of the most powerful things you can do for your memory, your focus, and your long-term brain health aren't found in a prescription. They're in your morning coffee, your nightly sleep, and the way you help your body recover every single day.I'm joined by returning guest expert Dr. David Perlmutter, a board-certified neurologist and 6-time New York Times bestselling author, to unpack the real science on the choices that shape cognitive function, metabolism, and longevity. We get into why coffee is so much more than caffeine, how deep sleep literally washes waste out of your brain overnight, why tracking your sleep might be one of the smartest health moves you make, and what the research actually says about infrared saunas, cold plunges, and heart rate variability. It's practical, it's evidence-based, and you can start using it today.What You'll Learn:• Why coffee is far more than caffeine, and the 90-plus bioactive compounds that may help protect your brain• The daily coffee sweet spot, and the "caffeine curfew" that guards your deep sleep• How to choose cleaner coffee: organic, mold-free, water-processed decaf, and why flavored blends are a gamble• Quality over quantity: why "I slept 8 hours" tells you almost nothing about your brain• How deep sleep activates the glymphatic system to wash away waste tied to cognitive decline, and the minimum you should aim for• The everyday habits that quietly sabotage restorative sleep, and why a wearable can help you fix them• What HRV really measures, why higher means more resilient, and simple ways to raise yours• Hot & Cold therapy: What the science says about infrared saunas and cold plunges, and why heat and cold may share the same protective pathways• A crucial caution for breast cancer survivors and anyone at risk for lymphedema before starting heat or cold therapy• The Mouthwash Habit Your Didn't Realize Is Harming You: The surprising connection between your mouth bacteria, mouthwash, blood pressure, and blood sugar• Brain-Boosting Movement: Why exercise acts like medicine, turning your muscles into hormone-producing organs that support your brain...and so much more!About Our Guest Expert:Dr. David Perlmutter is a board-certified neurologist, Fellow of the American College of Nutrition, and 6-time New York Times bestselling author. Recognized as one of the world's leading voices in brain health, he has spent decades translating cutting-edge neuroscience into practical strategies that help people reduce their risk of neurodegenerative disease and support lifelong wellness. He's the author of bestsellers including Grain Brain, Brain Wash, and Drop Acid, with his newest book, Brain Defenders, released in 2026.Connect with Dr. David Perlmutter:Instagram: @davidperlmutterFacebook: Dr. David PerlmutterWebsite: drperlmutter.com_________________________________________Get Cleaner, Regulated, Better Supplements for LessDid your last order of vitamins come off a big online overnight shipping platform but you have no idea how long it was sitting in an overheated warehouse?Or maybe those Omega-3's you take are actually rancid but you wouldn't know?That's why I'm excited to have found a platform that is not only efficacious and 3rd-party lab tested, but also regulated to have the ingredients in them that are on the label!And Fullscript has 100+ brands of supplements you may already be taking…only better. Safer. What your family needs.Yup — your one-stop shop for high-quality wellness and supplement products from brands people actually trust.Better still? I have been able to secure the most awesome discounts for you. Every order. Every day of the year. Even more savings with auto-ship.Whether you're leveling up your health routine, trying to stay consistent, or just attempting to remember to take your vitamins before 11 PM, Fullscript makes the whole process way easier.✨ Easy online ordering✨ Practitioner-trusted supplement brands✨ Personalized wellness support✨ Delivered straight to your door (because leaving the house is optional)Just click HERE to set up a free account. Or visit:https://us.fullscript.com/welcome/samanthaharris_store/store-start_________________________________________Why wash clothes with toxic cleaners? Try this instead!It shocked me that our laundry rooms are often one of the most toxic places in our homes.After breast cancer, I began changing out my personal care and beauty but didn't even think about my cleaning supplies.For laundry, I found a few brands that are really clean and free of harmful ingredients, but still searched for that fresh scent without the toxic junk.Found it finally! Here is the link to it (and you can message me to check to see if there are any great offers happening with current savings!CLICK THIS LINK for the details and get 100 FREE LOADS

Women are far more likely than men to develop Alzheimer's disease, and Dr. David Perlmutter believes one of the most important pieces of that story is metabolic health.In this episode of Live Like a Girl, Dr. Perlmutter joins Dr. Mindy to explain what happens when the brain's immune cells shift from protective to destructive, why menopause may increase vulnerability, and how blood sugar, insulin resistance, visceral fat, inflammation, mitochondrial health, and lifestyle all influence brain aging.They also discuss HRT, GLP-1 medications, ketones, fasting, fiber, exercise, BNDF, sleep, and what women can begin doing in their 30s, 40s, and 50s to support long-term cognitive health.In This Episode, You'll LearnWhy women face a higher risk of Alzheimer'sHow menopause may affect brain metabolismWhy belly fat and insulin resistance matter for brain healthThe blood markers Dr. Perlmutter watches most closelyWhat emerging research says about GLP-1 drugs and the brainThe lifestyle habits Dr. Perlmutter prioritizes for preventionResources MentionedBrain DefendersTanzi StudyCochrane ReviewMore on Dr. David Perlmutterhttps://drperlmutter.com/http://braindefenders.com/https://www.instagram.com/davidperlmutter/https://www.youtube.com/user/DavidPerlmutterMDhttps://x.com/davidperlmutterlinkedin.com/in/david-perlmutter-mdFor more resources related to today's episode, visit the podcast episode page: https://www.drmindypelz.com/ep363/Connect with Dr. Mindy:Join Reset AcademyWatch the episodes on YouTubeFollow Dr. Mindy on InstagramSubscribe to Dr. Mindy's newsletterDisclaimer: This podcast is intended for educational and informational purposes only and is not a substitute for professional medical advice. Always consult a qualified healthcare professional before making changes to your diet, fasting routine, or lifestyle.

What if protecting your brain starts decades before memory problems ever appear? In this conversation, I sit down with neurologist and bestselling author Dr. David Perlmutter to talk about what current research says about dementia prevention, why metabolic health may play a much larger role than many people realize, and why waiting until cognitive symptoms develop may be waiting too long. We get into the connection between blood sugar, insulin resistance, inflammation, gut health, sleep, exercise, and brain function, along with why so many of these risk factors begin showing up in our 30s and 40s rather than later in life. We also spend time on topics that generate a lot of questions in my practice, including hormone therapy, women's brain health, alcohol, stimulants, and the current state of dementia treatments. Dr. Perlmutter shares his perspective on why prevention deserves more attention, how lifestyle interventions fit into the conversation alongside medical care, and what practical markers people can monitor to better understand their long-term brain health. Topics We Cover in This Episode:  Why brain health may be shaped long before memory loss ever begins How metabolic health and inflammation may influence cognitive function The relationship between gut health, sleep, and long-term brain resilience Why women face unique considerations when it comes to dementia risk How Dr. Perlmutter views bioidentical hormone therapy in the context of brain health What current evidence suggests about alcohol, stimulants, and cognitive wellness Which everyday health markers may provide insight into future brain health Why prevention may be more impactful than waiting for symptoms to appear If you're interested in protecting your brain health for the long term and understanding how everyday lifestyle choices fit into that picture, I think you'll love this episode. Resources & Links Connect with Dr. Perlmutter: https://drperlmutter.com/  Brain Defenders: http://braindefenders.com/  Follow on IG: https://www.instagram.com/davidperlmutter/  Follow on YouTube: https://www.youtube.com/user/DavidPerlmutterMD  Connect on X: https://x.com/davidperlmutter  Connect on LinkedIn: linkedin.com/in/david-perlmutter-md  Order Dr. Cassie's Book ‘Fix Your Gut, Fix Your Hormones': https://guthormonefix.com/ Use code LISTEN10 for 10 % off your order on shopmodernendocrine.com 

By the time memory begins to slip, the changes affecting the brain may have been developing for decades. But the trajectory isn't fixed, and many of the factors driving it are within our control. In this episode, I sit down with my longtime friend and mentor Dr. David Perlmutter, six-time New York Times bestselling author whose new book, Brain Defenders, rethinks what it really takes to protect the brain as we age. You'll learn: Why protecting your brain should begin long before memory problems appear How your daily choices influence whether the brain's immune cells shift into a protective or damaging state Which numbers to know now, including fasting insulin, blood sugar, and waist-to-hip ratio How food, exercise, sleep, gut health, and environmental toxins shape your brain's future What emerging research reveals about slowing—and even improving—cognitive decline I've always appreciated how David's work replaces fear with something far more useful: a clearer understanding of how the choices we make today can help protect our memory, independence, and quality of life for years to come. View Show Notes From This Episode Sign up for Dr. Hyman's Brainshaping Academy to learn how to nourish the biological systems that support your mental, emotional, and cognitive health https://drhyman.com/products/brainshaping?utm_source=dr_hyman_show&utm_medium=newsletter&utm_campaign=may_27&utm_content=link Get Free Weekly Health Tips from Dr. Hyman https://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Sign Up for Dr. Hyman's Weekly Longevity Journal https://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Join the 10-Day Detox to Reset Your Health https://drhyman.com/pages/10-day-detox Join the Hyman Hive for Expert Support and Real Results https://drhyman.com/pages/hyman-hive This episode is brought to you by Paleovalley, Pique, Perfect Amino, BON CHARGE, Cozy Earth, and Fatty15. Shop nutrient-rich foods and supplements at paleovalley.com/hyman and save 15% off your first order. Elevate your daily wellness ritual at piquelife.com/hyman and enjoy 20% off plus free gifts. Help fill protein gaps at bodyhealth.com and use code HYMAN20 for 20% off. Explore red light products at boncharge.com/hyman and enjoy 15% off with code HYMAN. Upgrade your sleep setup with cozyearth.com and enjoy 20% off  with code HYMAN. Head to fatty15.com/HYMAN today and use code HYMAN for 15% off your 90-day subscription Starter Kit.

In this episode, neurologist and bestselling author Dr. David Perlmutter, author of Brain Defenders, explains how metabolism, inflammation, microglia, sleep, exercise, diet, and environmental exposures may shape your risk for Alzheimer's and other neurodegenerative diseases.This episode is proudly sponsored by:BUBS Naturals makes my favorite collagen, pure and unflavored, perfect for mixing into any drink, soup, or even recipes! Your hair, skin, and nails will thank you. Visit BUBSNaturals.com and use code GENIUS for 20% off.I sleep on an Avocado mattress because real organic materials, no synthetic shortcuts, and better breathability make a noticeable difference. Go to ⁠http://avocadogreenmattress.com/MAX⁠ to check out their mattress and bedding sale.ZBiotics Pre-Alcohol Probiotic Drink is the world's first genetically engineered probiotic, designed to help you feel better the day after drinking. Head to https://zbiotics.com/max for 15% off your first order.Kion is known for their transparent and evidence-based essential amino acid (EAA) supplements which help save you calories while providing all essential amino acids for muscle growth and more. Save 20% by going to ⁠getkion.com/geniuslife⁠.

Big Pharma bet billions on one theory: clear the amyloid, cure Alzheimer's.A new Cochrane review of 20,000+ patients just proved them wrong — these drugs don't work, and they may be putting your brain at risk. So what's really driving this epidemic?My guest today, six-time New York Times bestselling author and board-certified neurologist Dr. David Perlmutter, says the answer lies in a set of cells most people have never even heard of — and he lays it all out in his new book, Brain Defenders.The good news is, you already have more control over them than any drug could ever give you.We're talking about microglia, the brain's immune cells, and why the choices you make today may matter more than anything a prescription pad can offer.For full show notes and transcript: https://drgundry.com/david-perlmutter-alzheimersOn this episode, you'll learn: All about the new study that found leading Alzheimer's drugs deliver almost no benefit (02:09)Why the so-called enemy in your brain is not what we thought at all (07:34)What microglia are, and why these overlooked immune cells may be the real gatekeepers of your brain's health (05:15)How everyday metabolic issues like blood sugar and insulin resistance can affect your brain (09:30)Why one in nine Americans over 65 is already living with dementia (and most don't know it) (14:08)The surprising connection between Parkinson's, depression, and even autism spectrum conditions (15:11)How THIS lifestyle program helped 70% of Alzheimer's patients stabilize or even improve their cognitive function — no drugs required (17:09)The one mindset shift Dr. Perlmutter says has to happen before any diet or exercise plan will actually work for your brain (22:17)Why getting quality sleep does more for your brain than you think (27:49)The simple blood test you should request NOW to gauge your Alzheimer's risk (33:25)Why women make up two-thirds of Alzheimer's patients (35:29)The critical window for starting hormone replacement therapy (40:08)The truth about antibacterial mouthwash, and why it might be quietly working against your brain health (58:14)A 25-year-old flossing study that predicted exactly what today's top neurology journals are just now confirming (01:00:05)Dr. Perlmutter's honest answer to whether you should take the newer Alzheimer's drugs your doctor may be recommending (01:05:31)More about Dr. David Perlmutter:Dr. David Perlmutter's websiteDr. David Perlmutter's InstagramNew book: Brain Defenders: Harness the Power of Your Immune Cells to Protect Your Brain for Life by Dr. David PerlmutterResearch:Cochrane ReviewTanzi StudyThank you to our sponsors! Check them out: Transform your sleep experience with Cozy Earth bedding. Go to cozyearth.com/gundry for 20% off. Go to thrivemarket.com/GUNDRYPODCAST for 30% off your first order, plus a FREE $60 gift.Go to Quince.com/gundry to upgrade your wardrobe and get free shipping on your orderGet a quote today at Progressive.com.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this episode, Dr. Jockers sits down with neurologist and bestselling author Dr. David Perlmutter to explore microglia, the brain's immune cells, and the role they may play in protecting the brain from cognitive decline. You'll learn what can shift these cells from a supportive state toward one that promotes neuroinflammation.   Discover why your metabolic health and brain health are deeply connected. Dr. Perlmutter explains how blood sugar, insulin resistance, gut health, and chronic inflammation can influence microglial function and why addressing these factors may be important long before memory problems appear.   You'll also hear practical ways to support your brain through exercise, nutrition, sleep, metabolic flexibility, and other daily habits. Dr. Perlmutter shares why protecting your brain isn't just about what happens later in life—and how the choices you make today can help shape your cognitive future.   In This Episode:  00:00 Amyloid Myth Busted 00:15 Show Intro and Guest 04:18 Book Inspiration Microglia 06:02 Symptom Care vs Root Cause 09:51 Microglia M1 vs M2 11:15 Gut Brain Inflammation Link 15:01 Metabolism Mirrors Microglia 17:57 Infections Vaccines and Triggers 19:31 CTE Diabetes and Feedforward 25:20 New Tools and Beta Amyloid Drugs 30:37 Cochrane Verdict Drugs Fail 33:28 Lifestyle Trial Reverses Decline 38:23 Microglia Lifestyle Levers 39:07 Exercise Myokines Brain Boost 42:20 Alzheimers Risk Epigenetics 45:12 Imaging Microglia TSPO 46:24 Fasting Ketones Brain Fuel 49:45 MCT Oil Memory Care 51:16 POINTER Lifestyle Trial 55:57 Fiber Polyphenols Foods 58:34 Supplements DHA Vitamin D 01:02:23 Key Labs Glucose Tau 01:06:19 Prevention Mission Wrap 01:07:43 Final Thanks Outro   Enjoy a clean, protein-packed snack with PaleoValley's Grass-Fed Beef Sticks. Made without sugar, additives, or preservatives, they're packed with healthy fats and grass-fed nutrients to help curb cravings, support steady energy, and keep you satisfied on the go. Save 15% with code DRJOCKERS at paleovalley.com/drjockers.   Give your hair and skin routine an upgrade with iRestore's advanced red light therapy devices. The iRestore Elite combines 300 lasers and 200 LEDs to support thicker, healthier-looking hair, while the cordless Illumina Face Mask uses triple-wavelength light therapy to target fine lines, breakouts, and dullness. Take advantage of iRestore's Labor Day savings and huge discounts at iRestore.com and use promo code DRJOCKERS to save. Stop guessing about your health and start understanding what's happening inside your body with Superpower Health. One simple blood draw measures 100+ biomarkers covering your heart, liver, thyroid, hormones, metabolism, vitamins, minerals, and environmental toxins, plus you'll get ongoing tracking and access to a clinician team. Head to Superpower.com and use promo code JOCKERS to get $20 off your membership for a limited time.    Support your joints, hair, nails, skin, and recovery with BUBS Naturals Collagen Peptides, a tasteless, odorless formula that mixes easily into coffee, smoothies, or juice. It has zero sugar, sweeteners, or fillers and is third-party tested, NSF Certified for Sport, Whole30 Approved, and sustainably sourced from grass-fed, pasture-raised cattle. Head to BUBSNaturals.com and use promo code DRJOCKERS to get 20% off for a limited time. "Exercise isn't just changing your body. It's changing the environment inside your brain."   Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean  TuneIn Radio   Resources:  Enjoy 15% off grass-fed beef sticks with code DRJOCKERS at paleovalley.com/drjockers. Go to iRestore.com and use promo code DRJOCKERS Visit Superpower.com and use promo code JOCKERS to get $20 off Visit BUBSNaturals.com and use promo code DRJOCKERS to get 20% off     Connect with Dr. David Perlmutter: Book - https://a.co/d/06cRZKlT Website - https://drperlmutter.com/   Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https:/www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/   If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/

For so many people, the thought of memory loss or cognitive decline feels frightening. But today's guest shares an empowering message: there is so much we can do through our daily choices to support brain health and reduce risk. I'm joined by Dr. David Perlmutter, board-certified neurologist, leading brain health expert, and bestselling author of Brain Defenders, to discuss what we can do today to protect our brains as we age.  We explore the important shift in how we understand brain health, looking at the bigger picture of immunometabolism, metabolic health, inflammation, and the environment that influences the brain long before symptoms appear. Dr. Perlmutter explains why habits that support the entire body, including blood sugar balance and reduced inflammation, can also support cognitive health.  He also shares exciting areas of research and reminds us that even small changes can create meaningful improvements over time. Just like we can take steps to support our bones, we can also support our brains through the choices we make every day.   "Your brain's destiny is in your hands. It's based upon the choices that you are going to make every single day. A cure for dementia is not going to be given to you in the form of a medication." ~ Dr. David Perlmutter   In this episode: - [03:22] - The new science of brain health and immunometabolism - [11:19] - Metabolic health and its impact on cognitive decline - [17:26] - Blood sugar, insulin resistance, and brain health - [28:35] - How to protect your brain as you age - [31:37] - Lab tests for proactive brain health - [39:15] - Environmental toxins, plastics, and brain health - [45:26] - Emerging therapies and the future of brain protection - [52:08] - Resources from Dr. Perlmutter   Resources - Osteoporosis Exercises to Strengthen Your Bones and Prevent Fractures - https://tinyurl.com/mystrongbonesexercises - Dr. Perlmutter's new book, Brain Defenders - https://drperlmutter.com/books/brain-defenders/ - Dr. Perlmutter's website - https://drperlmutter.com/   More about Margie - Website - https://margiebissinger.com/  - Facebook - https://www.facebook.com/p/Margie-Bissinger-MS-PT-CHC-100063542905332/  - Instagram - https://www.instagram.com/margiebissinger/?hl=en    DISCLAIMER – The information presented on this podcast should not be construed as medical advice. It is not intended to replace consultation with your physician or healthcare provider. The ideas shared on this podcast are the expressed opinions of the guests and do not always reflect those of Margie Bissinger and Happy Bones, Happy Life Podcast. *In compliance with the FTC guidelines, please assume the following about links on this site: Some of the links going to products are affiliate links of which I receive a small commission from sales of certain items, but the price is the same for you (sometimes, I even get to share a unique discount with you). If I post an affiliate link to a product, it is something that I personally use, support, and would recommend. I personally vet each and every product. My first priority is providing valuable information and resources to help you create positive changes in your health and bring more happiness into your life. I will only ever link to products or resources (affiliate or otherwise) that fit within this purpose.

Dr. Doug sits down with neurologist and bestselling author, Dr. David Perlmutter, to explore the surprising overlap between brain health and bone health. They discuss how nutrition, metabolic health, exercise, sleep, inflammation, and muscle all influence long-term cognitive and skeletal health. Dr. Perlmutter also shares why protecting your brain starts long before cognitive decline appears, and why lifestyle may be one of the most powerful tools we have.Dr. Perlmutter's new book available for purchase here: https://braindefenders.com/Connect with Dr. Perlmutter:https://drperlmutter.com/https://www.instagram.com/davidperlmutter/https://www.youtube.com/user/DavidPerlmutterMDhttps://x.com/davidperlmutterlinkedin.com/in/david-perlmutter-md

Episode Highlights With DavidWhy living an adventurous lifestyle is so good for your brain and bodyBeing sedentary is one of the biggest things that threatens brain health- here's whyWhy he considers brain defenders the most urgent and important thing he's ever writtenWhat the brains immune system is and why this is vital to understanding long term brain healthMicroglial cells and why these matterWhy it isn't just about beta amyloid plaques for alzheimer's and why this thinking was harmfulThe reason many drugs designed to address alzheimer's are not just ineffective but dangerousHow one study showed completely stopping the decline of alzheimer's with lifestyle intervention and actually showed improvementNurturing mitochondrial function helps the brain support M2 cells that are protectiveBrain metabolism mirrors the body's metabolism and how being metabolically healthy protects the brainEven one night of non-restorative sleep can impact the brainExercise is a tonic for the brain and bathes the brain in protective compoundsHow to protect the brain from the problems of less sleep even postpartum (there is an amazing built in protective mechanism from oxytocin)Why this means human connection is brain protective as well and community matters for brain healthWhat the latest research says about statins and what we need to understand His take one gamma light, olfactory signaling and hyperbaric for brain healthResources MentionedBrain Defenders: Harness the Power of Your Immune Cells to Protect Your Brain for Life by David Perlmutter, MDBrain Maker: The Power of Gut Microbes to Heal and Protect Your Brain for Life by David Perlmutter, MDGrain Brain: The Surprising Truth about Wheat, Carbs, and Sugar--Your Brain's Silent Killers by David Perlmutter, MDJaspr Air FilterLMNTI talk often about the health benefits of salt and electrolytes and I am a big fan of LMNT canned drinks and packets. Go to drinklmnt.com/wellnessmana for a special offer.HiyaHiya created a super powered chewable vitamin for kids that packs twelve organic fruits and vegetables plus fifteen essential vitamins and minerals into every dose. Try it at hiyahealth.com/wellnessmama.

Dr. David Perlmutter — neurologist, New York Times bestselling author, and author of the new book Brain Defenders — joins Dr. Will Cole to reveal what he believes is the most important breakthrough in brain health science in decades: the microglial cell. He explains why the amyloid hypothesis that has dominated Alzheimer's research (and pharmaceutical spending) for 30 years has been definitively disproven by a Cochrane analysis, why a Harvard lifestyle study arrested Alzheimer's decline in 70% of patients without any drug, and what the April 2024 NEJM GLP-1 Parkinson's trial means for the future of neurodegenerative disease. They also cover the practical daily habits, foods, supplements, and lab tests that shift the brain's immune cells from destructive to protective — and why you are far more the architect of your brain's destiny than anyone has told you. For all links mentioned in this episode, visit http://www.drwillcole.com/podcastPlease note that this episode may contain paid endorsements and advertisements for products and services. Individuals on the show may have a direct or indirect financial interest in products or services referred to in this episode.Sponsors:Take the first step and learn at a pace that works for you. Visit WaldenU.edu.Give them meals + snacks that are actually right for where kids are developmentally - balanced, intentional and made to support real growth. Go to littlespoon.com/WILLCOLE and enter code WILLCOLE for 30% off your first order.Get a free 8-count Sample Pack of LMNT's most popular drink mix flavors with any purchase at drinklmnt.com/artofbeingwell. Find your favorite flavor, or share with a friendQUINCE.COM/WILLCOLE for free shipping and 365 day returns. Now available in Canada too! www.jshealthvitamins.com code WILLCOLE for 15% off at checkout LIFT Oléoactif® significantly reduced the primary wrinkle by more than 200%.† OR 200% reduction in wrinkles with LIFT Oléoactif®†* Disclaimer: *Clinical test: LIFT Oléoactif® in cream, results in 28 days, compared to placebo. LIFT Oléoactif® is a trademark of HALLSTAR FRANCE SAS. 95% see a reduction in eyebag volume* with Eyeseryl® Peptide Disclaimer: *Clinical test: EYESERYL® Peptide in cream, results in 28 days. EYESERYL® Peptide is a trademark of Lubrizol Advanced Materials, Inc. or its affiliates.Produced by Dear Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

“We can choose our brain's destiny,” says David Perlmutter, MD. Perlmutter is a Board-Certified Neurologist and six-time New York Times bestselling author whose work focuses on the intersection of neurology, nutrition, and brain health. He is on the Board of Directors of the American College of Nutrition and the Editorial Board of the Journal of Alzheimer's Disease. His books, including the #1 bestseller Grain Brain, has been published in 32 languages and sold over a million copies. Perlmutter lectures globally at leading institutions and has been featured on major media outlets including 20/20, CNN, The Today Show, and Oprah. His new book, Brain Defenders, focuses on the pivotal role of microglia, the brain's immune cells, in protecting, repairing, and reprogramming the brain for lifelong resilience, and is now available for pre-order. 00:00 - Treating the symptoms, not the cause  02:37 - Microglial cells & their evil twin state  05:44 - How metabolism affects the brain  08:00 - Gut bacteria, inflammation, & brain degeneration  11:38 - Why lifestyle beats the APOE4 gene  16:25 - Perlmutter's daily routine 23:55 - Loneliness & oxytocin  26:21 - The effects of long COVID on the brain 32:18 - Glyphosate & other environmental factors  39:20 - Reprogramming microglia & mitochondrial transplants  41:35 - Own your brain's destiny Referenced in the episode:  For more about Perlmutter, visit his website: https://drperlmutter.com/  Alzheimers & UPFs study: https://doi.org/10.1016/j.tjpad.2024.100042  POINTER study - https://jamanetwork.com/journals/jama/fullarticle/2837046  20-week Alzheimer's study:  https://link.springer.com/article/10.1186/s13195-024-01482-z  Golf course & Parkinson's study: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2833716  We hope you enjoy this episode, and feel free to watch the full video on YouTube! Whether it's an article or podcast, we want to know what we can do to help here at mindbodygreen. Let us know at: podcast@mindbodygreen.com. Learn more about your ad choices. Visit megaphone.fm/adchoices

Dr. David Perlmutter is a Board-Certified Neurologist and six-time New York Times bestselling author whose work focuses on the intersection of neurology, nutrition, and brain health. A Fellow of the American College of Nutrition, he serves on its Board of Directors and on the Editorial Board of the Journal of Alzheimer's Disease. His books, including the #1 bestseller Grain Brain, have been published in 32 languages and sold over a million copies. Dr. Perlmutter lectures globally at leading institutions and has been featured on major media outlets including 20/20, CNN, The Today Show, and Oprah. His contributions have earned him numerous national and international awards for clinical innovation and leadership. Today on the show, we discuss why Alzheimer's may be driven more by lifestyle than genetics, how insulin resistance and blood sugar can quietly damage the brain, the foods and eating habits that may protect cognitive health, why sleep, exercise, and social connection are critical for preventing decline, what caffeine, nicotine, marijuana, and alcohol actually do to the brain, and the simple changes you can start making today to protect your memory for decades to come. Thank you to today's sponsor: Momentous Try Momentous Signature Spec Creatine: https://www.livemomentous.com Use code ADVERSITY for up to 35% off your entire first order Learn more about your ad choices. Visit megaphone.fm/adchoices

  In this episode of Resiliency Radio with Dr. Jill, Dr. Jill Carnahan welcomes renowned neurologist and bestselling author Dr. David Perlmutter to explore the emerging science behind brain health, neuroinflammation, and cognitive resilience. Drawing from his groundbreaking new book, Brain Defenders, Dr. Perlmutter explains how microglia—the brain's immune cells—play a central role in protecting or damaging the brain depending on our metabolism, lifestyle, and environment. Together they discuss why Alzheimer's and Parkinson's disease begin decades before symptoms appear, why inflammation and insulin resistance are major drivers of neurodegeneration, and what we can do today to protect lifelong brain health. Whether you're concerned about memory loss, dementia prevention, or optimizing cognitive performance, this episode offers science-backed strategies to build a healthier, more resilient brain.

In this episode, we sit down with neurologist Dr. David Perlmutter to explore the fascinating science behind optimal brain health. We dive deep into topics from microglial cells and immunometabolism to the importance of addressing root causes like lifestyle and diet for preventing neurodegenerative diseases.Dr. David Perlmutter shares his journey into integrative neurology, emphasizing how metabolic health, inflammation, and stress impact brain function. The conversation covers practical insights on how dietary choices, exercise, sleep, and stress management can maintain cognitive vitality and longevity. Groundbreaking concepts like biological aging, mitochondrial health, and the latest research on treatments and prevention round out an empowering and thought-provoking discussion.Ready to take control of your brain's future? Listen in, share this episode with three friends, and start applying these empowering insights to upgrade your health. Don't forget to check out Dr. Perlmutter's new book, Brain Defenders, for deeper guidance.  Dr. Navaz HabibEmail: podcast@healthupgraded.comFacebook: https://www.facebook.com/DrNavazHabib/Instagram: https://www.instagram.com/drnavazhabib/LinkedIn: https://ca.linkedin.com/in/drnavazhabibJP ErricoInstagram: https://www.instagram.com/thevnsguy/LinkedIn: https://www.linkedin.com/in/jp-errico-097629aaDr. David PerlmutterWebsite: https://drperlmutter.com/Books: https://drperlmutter.com/books/

In this episode of Revolution Health Radio, Chris Kresser sits down with renowned neurologist and bestselling author Dr. David Perlmutter to discuss the emerging science of microglia—the brain's immune cells—and why they may hold the key to preventing cognitive decline and Alzheimer's disease. Drawing from his new book, Brain Defenders, Dr. Perlmutter explains how lifestyle factors such as nutrition, exercise, sleep, metabolic health, and gut health influence whether microglia protect the brain or contribute to chronic inflammation and neurodegeneration. Together, they challenge the outdated notion that dementia is largely predetermined by genetics, highlighting growing evidence that proactive lifestyle interventions can preserve—and even improve—brain function throughout life. The post RHR: Why Microglia Are the Key to Brain Health, with Dr. David Perlmutter appeared first on Chris Kresser.

Dr. David Perlmutter is a board-certified neurologist and New York Times bestselling author known for his work on brain health.Show partners:LMNT - Claim your free LMNT Sample Pack with any purchase by using this linkJaspr - Save $200 off your Jaspr air scrubber by using this linkShow notes:jessechappus.com/717

In this new episode, Crawlspace Media's Tim Pilleri and Lance Reenstierna speak with Professor and Dr. David Perlmutter of Texas Tech University about the mysterious disappearance of Liz Waddell from Grand Anse Beach, St. George, Grenada on Wednesday, July 22, 2026. If you have any information in the disappearance of Liz Waddell please call 1-473-444-4454. Find Liz official site: https://findliz.com/. Please share any information, no matter how small, with the proper authorities or email tips@findliz.com. Check out Quince: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://quince.com/MISSING⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Check out Mint Mobile: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠mintmobile.com/missing⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Check out Kensington Publishing: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.kensingtonbooks.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Main podcast theme by Kevin Macleod. Check out his work at⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://incompetech.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Additional music by David Williams. See his work at⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠http://williamsflutes.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Follow Missing: IG: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/MissingCSM/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Youtube:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.youtube.com/missingcsm⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. FB:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.facebook.com/MissingCSM⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. X:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://twitter.com/MissingCSM⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Spotify:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://open.spotify.com/show/0yRXkJrZC85otfT7oXMcri⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Apple:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://podcasts.apple.com/us/podcast/missing/id1006974447⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Follow Crawlspace: IG:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.instagram.com/Crawlspacepodcast⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. TT:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.tiktok.com/@crawlspacepodcast⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. FB:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.facebook.com/Crawlspacepodcast⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. X:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://twitter.com/crawlspacepod.⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Spotify:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://open.spotify.com/show/7iSnqnCf27NODdz0pJ1GvJ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Youtube:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.youtube.com/crawlspace⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Apple:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://podcasts.apple.com/us/podcast/crawlspace-true-crime-mysteries/id1187326340⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Check out our entire network at⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ http://crawlspace-media.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Learn more about your ad choices. Visit megaphone.fm/adchoices

Alzheimer's disease has grown to become the most common form of dementia, and as of now, there is no cure for this devastating neurodegenerative disease. But new science shows that your brain's immune cells play an essential role in how your brain ages. Today, you're going to learn this latest science and how to put it into action.  Today's guest, Dr. David Perlmutter is a board-certified neurologist and six-time New York Times bestselling author. His new book, Brain Defenders, dives into the groundbreaking discovery that immune cells in the brain are the key to brain health and longevity. On this episode, you're going to learn about this emerging science and what you can do to protect your brain now and as you age.  In this interview, you're going to learn about the fascinating science of immunometabolism, what microglial cells are, and the specific lifestyle habits that can shape the future of your brain. We're going to talk about specific foods and exercises that can dictate the health of your brain's immune cells, and proven strategies to protect your brain from degradation. Enjoy!  In this episode you'll discover: The one fundamental mechanism that connects all neurodegenerative diseases. (2:26) What the latest science says about the efficacy of Alzheimer's medications. (3:41) The essential function of microglial cells. (6:51)  What immunometabolism is. (8:41)  How having type 2 diabetes can increase your risk of Alzheimer's disease. (11:23) What GLP-1 drugs teach us about the link between the brain and metabolism. (12:12) How exercise helps defend the brain from degeneration. (29:12) The connection between myokines and metabolism. (29:54) Why flexibility and balance training are important for longevity. (36:57) The truth about fish oil supplements for brain health. (38:14) What to eat to defend your brain. (42:21) How eating ultraprocessed foods increases your risk of brain diseases. (45:38) Why stress impacts your brain health. (57:10) The simplest way to measure your health and activity levels. (1:08:23) Items mentioned in this episode include: DrinkLMNT.com/model - Get a truly meaningful dose of electrolytes in a science-backed ratio. Free sample pack with any order. Organifi.com/Model - Organifi makes nutrition easy and delicious for everyone. Take 20% off your order with the code MODEL. Brain Defenders by Dr. David Perlmutter - Preorder your copy of Dr. Perlmutter's new book today!  Grain Brain by Dr. David Perlmutter - Read about how your diet affects your brain health!  You've Been Pooping All Wrong by Dr. Trisha Pasricha - Learn about gut health and how to poop better!  Connect with Dr. David Perlmutter Website / Podcast / Facebook / Instagram  Be sure you are subscribed to this podcast to automatically receive your episodes:  Apple Podcasts Spotify Soundcloud Pandora YouTube  This episode of The Model Health Show is brought to you by LMNT and Organifi.  Most people are underhydrated—and it's costing you energy, focus, and performance. LMNT delivers a science-backed electrolyte ratio with no sugar, no junk—just what your body actually needs. Get a free sample pack with any order at drinklmnt.com/model.  Make nutrition effortless—and actually enjoyable. Organifi's delicious, superfood blends help you boost energy, reduce stress, and feel your best every day. Get 20% off with code MODEL at organifi.com/model. 

Alzheimer's isn't just a diagnosis that shows up in old age. It's a slow metabolic unraveling that can start decades before the first symptom. In this episode, Jeff sits down with Dr. David Perlmutter, a board-certified neurologist and author of the new book Brain Defenders (out August 18), to unpack what's really driving Alzheimer's and other neurodegenerative diseases. They get into the brain's own immune system, the microglial cells that either protect or destroy your neurons, and why the beta-amyloid hypothesis may have sent decades of research down the wrong path. Why microglia, not amyloid plaques, may be the true driver of brain degeneration The link between insulin resistance, blood sugar, and neuroinflammation How the gut microbiome and oral health shape the brain's immune response Practical diet, sleep, and supplement strategies to protect your brain starting now This episode is for anyone who wants to understand Alzheimer's prevention before symptoms start, and for the millions currently caring for a parent or partner facing cognitive decline. Preorder Dr. David Perlmutter's new book “Brain Defenders” at braindefenders.com.   This episode was made possible by: CocoaVia:. Use code COMMUNE2026 for 25% off at CocoaVia.com LMNT: Get a free 8-count Sample Pack of LMNT's most popular drink mix flavors with any purchase at ⁠⁠drinklmnt.com/commune⁠⁠. Stemregen: Get 20% off your first order at stemregen.co/commune with the code COMMUNEPOD Vivobarefoot: Try Vivobarefoot risk-free with a 100-day return guarantee, and get 25% off your order at ⁠⁠vivobarefoot.com/commune⁠⁠. Stripes: Visit stripesbeauty.com and use the code COMMUNE20 for 20% off our entire product line.

While it may be simplistic to say that the Blackberry died at the hands of the iPhone, it wouldn't be entirely inaccurate. That death, however, was a very beautiful corpse as one might imagine due to Blackberry device becoming so ubiqutous as to have a nickname: "Crackberry". Join Chris, Dr. David Perlmutter, and Mark Stachiw as they talk all about the film as well as the history surrounding it and much more.Become a supporter of this podcast: https://www.spreaker.com/podcast/the-kulturecast--2883470/support.

In this new episode, Crawlspace Media's Tim Pilleri and Lance Reenstierna discuss the mysterious death of Austria's Christian Pilnacek in October of 2023 with Dr.'s Sarah Schiffecker and David Perlmutter from Texas Tech University. Christian Pilnacek was a prominent Austrian lawyer and former judge who rose to become one of the most powerful officials in the country's Ministry of Justice before being suspended amid controversy. While his October 2023 death in a Danube tributary was quickly ruled a suicide, the circumstances remain surrounded by mystery due to allegations of a sloppy investigation and suspected political interference. Check out Dr. Schiffecker's work: ⁠⁠⁠⁠⁠https://www.depts.ttu.edu/comc/faculty/faculty/sschiffecker.php⁠⁠⁠⁠⁠. Check out Dr. Perlmutter's work: ⁠⁠⁠⁠⁠⁠⁠https://www.depts.ttu.edu/comc/faculty/faculty/dperlmutter.php⁠⁠⁠⁠⁠. Check out Quince: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://quince.com/MISSING⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Check out Mint Mobile: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠mintmobile.com/missing⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Check out Kensington Publishing: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.kensingtonbooks.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Main podcast theme by Kevin Macleod. Check out his work at⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://incompetech.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Additional music by David Williams. See his work at⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠http://williamsflutes.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Follow Missing: IG: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/MissingCSM/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Youtube:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.youtube.com/missingcsm⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. FB:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.facebook.com/MissingCSM⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. X:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://twitter.com/MissingCSM⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Spotify:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://open.spotify.com/show/0yRXkJrZC85otfT7oXMcri⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Apple:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://podcasts.apple.com/us/podcast/missing/id1006974447⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Follow Crawlspace: IG:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.instagram.com/Crawlspacepodcast⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. TT:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.tiktok.com/@crawlspacepodcast⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. FB:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.facebook.com/Crawlspacepodcast⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. X:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://twitter.com/crawlspacepod.⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Spotify:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://open.spotify.com/show/7iSnqnCf27NODdz0pJ1GvJ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Youtube:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.youtube.com/crawlspace⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Apple:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://podcasts.apple.com/us/podcast/crawlspace-true-crime-mysteries/id1187326340⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Check out our entire network at⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ http://crawlspace-media.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Learn more about your ad choices. Visit megaphone.fm/adchoices

Neurologist and bestselling author Dr. David Perlmutter returns to discuss the groundbreaking science behind his new book, Brain Defenders. Together, we unpack why Alzheimer's disease may be driven less by amyloid plaques and more by chronic inflammation, metabolic dysfunction, and changes in the brain's immune cells. Dr. Perlmutter explains the critical role of microglia, how blood sugar and insulin resistance affect the brain, why gut health is directly connected to cognitive function, and what lifestyle habits have the strongest evidence for protecting memory as we age. → Leave Us A Voice Message!  Topics Discussed: → What causes Alzheimer's disease? → How do you prevent Alzheimer'? → What foods improve brain health? → Can inflammation cause dementia? → Does blood sugar affect memory? Sponsored By:  → Function | Check your health the way I do. Function provides 160+ lab tests for $1/day and member pricing on advanced imaging. Join at https://functionhealth.com/bewellbykelly and use code BEWELL25 for a $25 credit. → Be Well By Kelly Protein Powder & Essentials | Get $10 off your order with PODCAST10 at https://bewellbykelly.com. → Shop minnow's new apré-ski capsule collection at https://shopminnow.com and enter code MEETMINNOW15 at checkout to receive 15% off your first order. → LMNT | Get a free 8-count Sample Pack of LMNT's most popular drink mix flavors with any purchase at https://drinklmnt.com/Kelly. Find your favorite LMNT flavor, or share with a friend. → Branch Basics | Go to https://branchbasics.com/BEWELLPODCAST and use code: BEWELLPODCASTfor 15% off your first purchase.  Timestamps:  → 00:00:00 - Introduction → 00:03:07 - Why Alzheimer's Research Is Changing → 00:05:42 - Microglia Explained → 00:10:44 - Understanding Immunomatabolism  → 00:15:10 - Insulin Resistance + "Type 3 Diabetes" → 00:19:27 - Long COVID + Brain Recovery → 00:30:20 - Lifestyle Changes For Brain Health  → 00:35:22 - The Gut Microbiome → 00:37:27 - Tracking Gut Health  → 00:39:26 - Early Biomarkers/Testing  → 00:45:20 - Exercise + Muscle → 00:49:51 - Children's Nutrition  → 00:52:48 - Women's Dementia Risk   → 00:58:53 - GLP1s + Other Peptides   → 01:07:41 - Dr. Perlmutter's Daily Brain Health Routine Further Listening:  → Nutrition for a Healthy Brain & Body (Without Counting Calories) | Max Lugavere Check Out David: → Book | Braindefenders.com → Website → Instagram  Check Out Kelly: → Instagram → Youtube → Facebook

Neurologist Dr. David Perlmutter Explains Brain Inflammation and Alzheimer's Risk Your brain has its own immune system, and when it turns against you, it becomes the hidden driver behind Alzheimer's, Parkinson's, depression, and even long COVID. This episode hands you the science to recognize it early and reverse it. Get Dr. Perlmutter's new book Brain Defenders: https://drperlmutter.com/books/brain-defenders/ Host Dave Asprey sits down with Dr. David Perlmutter, a board-certified neurologist and six-time New York Times bestselling author whose work sits at the intersection of neurology, nutrition, and brain health. He is a Fellow of the American College of Nutrition, serves on its Board of Directors, and sits on the Editorial Board of the Journal of Alzheimer's Disease. His books, including the number one bestseller Grain Brain, span 32 languages and have sold over a million copies, and his upcoming release, Brain Defenders, explores the pivotal role of microglia, the brain's immune cells, in protecting, repairing, and reprogramming the brain for lifelong resilience. Dave and Dr. Perlmutter break down how microglia, the brain's resident immune cells, shift from a supportive state into a destructive one called M1, and why this shift, not amyloid plaque, may be the real driver of Alzheimer's, Parkinson's, and other neurodegenerative conditions. They dig into why the leading amyloid-clearing drugs fail to improve cognition, what a landmark JAMA study revealed about reversing cognitive decline through lifestyle intervention alone, and why a single daily serving of ultra-processed food raised Alzheimer's risk by 13 percent in a 12.7 year study. They also cover new research on GLP-1 drugs and brain inflammation, the surprising role of gum disease and oral bacteria in dementia risk, and why 40 hertz light therapy is emerging as a low-cost tool for clearing brain plaque and calming neuroinflammation. You'll Learn: Why the shift from supportive to destructive brain immune cells may be the true root cause of Alzheimer's and Parkinson's Why leading Alzheimer's drugs fail to improve cognition, and what the original research behind the amyloid hypothesis actually showed How one daily serving of ultra-processed food raises Alzheimer's risk, and what a landmark lifestyle intervention study found instead Whether GLP-1 drugs help or harm brain inflammation, based on new Parkinson's and Alzheimer's trial data How gum disease and oral bacteria are linked to dementia, and simple daily habits that reduce that risk Why 40 hertz light therapy is emerging as a tool to clear brain plaque and calm neuroinflammation How ketones, DHA, and metabolic health protect the brain after head injury Thank you to our sponsors! - Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com. - ZenBud | Dave's Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount. - Pique | Head over to Piquelife.com/Dave to get 20% off your order. That's P-I-Q-U-E life dot com slash DAVE - PredictiveMind™ | Get your Brain Pattern Mapping report at predictivemind.io/dave and use code DAVE for 10% off. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: microglia, brain inflammation, Alzheimer's prevention, Parkinson's disease, amyloid hypothesis, neurodegeneration, GLP-1 drugs, semaglutide, ultra-processed food, gum disease and dementia, oral microbiome, 40 hertz light therapy, ketones, DHA, mitochondria, brain fog, long COVID, David Perlmutter, Brain Defenders, Grain Brain, functional medicine, biohacking, longevity, neuroplasticity Resources: • Get Dr. Perlmutter's New Book Brain Defenders: https://drperlmutter.com/books/brain-defenders/ • Learn More About Dr. Perlmutter's Work At: https://drperlmutter.com/ • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15? • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 00:40 – Intro 02:38 – Ultra-Processed Foods 06:34 – Are Carbs Bad? 08:48 – Alcohol & Brain Health 12:28 – Microglia & Inflammation 24:37 – Head Injury & Recovery 29:27 – Oral Bacteria & Dementia 34:08 – GLP-1s & Brain Inflammation 40:20 – 40 Hertz Light Therapy 48:35 – Air Pollution vs. Lead 50:27 – David's Closing Truth See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Immune Regulation, Omega-3 Nuance, and Himalayan Tartary Buckwheat with Dr. Austin Perlmutter, chief science officer of Big Bold Health. He details immune regulation as a nuanced, multidimensional system shaped by diet and lifestyle rather than simple “boosting.” Perlmutter explains Big Bold Health's focus on immunometabolism, educating about immune complexity, and conducting studies on nutraceuticals, including use of CGMs and clinical trials. He discusses why eating fish often outperforms refined fish-oil supplements, noting conventional processing (heat, bleaching, deodorizing, esterification) and loss of other lipids and nutrients. Perlmutter highlights specialized pro-resolving mediators (resolvins, protectins, maresins) and vitamins A and D as potentially better preserved in minimally processed oils, and reviews typical omega-3 intake and target ranges. The conversation also covers immunosenescence/inflammaging and Big Bold Health research on sprouted Himalayan Tartary Buckwheat, its high polyphenols (rutin, quercetin), microbiome effects, and studies including epigenetic aging clocks and brain outcomes.

In this new episode, Crawlspace Media's Tim Pilleri and Lance Reenstierna speak with Dr.'s Sarah Schiffecker and David Perlmutter about the media circus surrounding the Karen Read case. In this episode, we explore the complex case of Karen Reed, media coverage, and the impact of technology on justice. Our experts discuss media circus, social media influence, and the evolving standards of evidence in criminal justice. Check out Dr. Schiffecker's work: ⁠⁠⁠⁠https://www.depts.ttu.edu/comc/faculty/faculty/sschiffecker.php⁠⁠⁠⁠. Check out Dr. Perlmutter's work: ⁠⁠⁠⁠⁠⁠https://www.depts.ttu.edu/comc/faculty/faculty/dperlmutter.php⁠⁠⁠⁠. Check out Quince: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://quince.com/MISSING⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Check out Mint Mobile: ⁠⁠⁠⁠⁠⁠mintmobile.com/missing⁠⁠⁠⁠⁠⁠. Check out Kensington Publishing: ⁠⁠⁠⁠⁠⁠https://www.kensingtonbooks.com⁠⁠⁠⁠⁠⁠. Main podcast theme by Kevin Macleod. Check out his work at⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://incompetech.com/⁠⁠⁠⁠⁠⁠. Additional music by David Williams. See his work at⁠⁠⁠⁠ ⁠⁠http://williamsflutes.com⁠⁠⁠⁠⁠⁠. Follow Missing: IG: ⁠⁠⁠⁠https://www.instagram.com/MissingCSM/⁠⁠⁠⁠. Youtube:⁠⁠⁠⁠⁠ https://www.youtube.com/missingcsm⁠⁠⁠⁠⁠. FB:⁠⁠⁠⁠ https://www.facebook.com/MissingCSM⁠⁠⁠⁠. X:⁠⁠⁠⁠ https://twitter.com/MissingCSM⁠⁠⁠⁠. Spotify:⁠⁠⁠⁠ https://open.spotify.com/show/0yRXkJrZC85otfT7oXMcri⁠⁠⁠⁠. Apple:⁠⁠⁠⁠ https://podcasts.apple.com/us/podcast/missing/id1006974447⁠⁠⁠⁠. Follow Crawlspace: IG:⁠⁠⁠⁠ https://www.instagram.com/Crawlspacepodcast⁠⁠⁠⁠. TT:⁠⁠⁠⁠ https://www.tiktok.com/@crawlspacepodcast⁠⁠⁠⁠. FB:⁠⁠⁠⁠ https://www.facebook.com/Crawlspacepodcast⁠⁠⁠⁠. X:⁠⁠⁠⁠ https://twitter.com/crawlspacepod.⁠⁠⁠⁠ Spotify:⁠⁠⁠⁠ https://open.spotify.com/show/7iSnqnCf27NODdz0pJ1GvJ⁠⁠⁠⁠. Youtube:⁠⁠⁠⁠ https://www.youtube.com/crawlspace⁠⁠⁠⁠. Apple:⁠⁠⁠⁠ https://podcasts.apple.com/us/podcast/crawlspace-true-crime-mysteries/id1187326340⁠⁠⁠⁠. Check out our entire network at⁠⁠⁠⁠ http://crawlspace-media.com/⁠⁠⁠⁠. Learn more about your ad choices. Visit megaphone.fm/adchoices

Here's something I keep seeing in my office that almost nobody has language for. Your body and your nervous system run on completely different timelines. Your labs can be clear. Your divorce can be final. Your treatment can be done. And your nervous system can still be living inside the chapter you just survived, because nothing about getting through a hard thing actually tells your body it is safe to stop bracing. In this episode, I sit down with Amy Kurtz, the patient advocate who spent close to two decades trying to figure out why her body kept shutting down on her. Amy is a Hachette author whose new book But You Look Fine launches the day after this episode airs, and she coined a phrase for the exact experience I just described. She calls it Medical Trauma Brain. Her message has been endorsed by Mark Hyman, her own physician, and by David Perlmutter, Kris Carr, and Sharon Salzberg. After 36 doctors and a late-stage neurological Lyme diagnosis at 35, she didn't just heal physically. She figured out the part nobody warned her about. The part that comes after. In This Episode The exact phrase Amy's husband said in their kitchen that finally named what she could not name herself Why the gap between "you should be fine now" and "I do not feel fine" is not a personal failing Why this pattern is not just for chronic illness, it shows up after divorce, postpartum, fertility, caregiving, and any long hard chapter The five non-negotiables Amy now uses to decide whether a doctor is worth her time Why women carry this harder than men, both clinically and culturally What active movement actually does for an overstimulated nervous system (it is more than you think) The one tool Amy would give a woman tonight who is recognizing herself for the first time How to stay connected to the people you love when you are the person who is not okay This episode is for anyone who has technically gotten through something hard and quietly cannot understand why she still does not feel like herself. The illness that finally has a diagnosis. The divorce that is actually final. The postpartum body that healed on paper. The job she finally left. The caregiver who buried the person she was caring for and woke up the next morning still bracing. If you have been told you should be fine by now, and you are not, this conversation is going to give you language for what is actually happening in your body and a way forward that respects the timeline. Episode Breakdown: 00:02:04 The Gap Between Sick and Well Nobody Warned You About 00:05:10 36 Doctors and One Diagnosis: Amy's Story 00:13:25 What Is Medical Trauma Brain? 00:14:54 Why Your Body Still Doesn't Feel Safe (Even Though You're Fine) 00:21:05 How to Advocate for Yourself in a System That Won't 00:45:03 How to Regulate Your Nervous System After Trauma or Illness 00:51:01 The Wider Lens: Why This Isn't Just About Illness 00:56:00 The One Tool I'd Give a Woman Tonight Resources: Read the full article on this conversation, including everything we mentioned and where to find Amy's work Wondering what is keeping you stuck? Take our free What's Holding You Back quiz Ready to talk to someone about what you are carrying? Book a free consultation If a friend has been telling you she is fine and you can tell she is not, send her this episode. She will be glad you did. XO, Dr. Lisa Marie Bobby Growing Self Special thanks to this month's sponsors of the podcast: Upwork — When you need specialized talent fast, Upwork gives you access to vetted professionals across 125+ categories, from marketing to web development to operations support. No long recruiting cycles. No guesswork. Just the right person, when you need them. Check it out at upwork.com — posting a job is free. Shopify — The all-in-one platform for building and growing your online business. Visit shopify.com/lhs to explore their tools and access exclusive listener discounts. OSEA — Amazing, clean, science-backed skincare made with the power of the sea. Use code LHS at oseamalibu.com for 10% off your first order. LNutra Prolon — A science-backed, plant-based nutrition program that supports fat loss, metabolism, cellular rejuvenation, and overall longevity. Head to ProlonLife.com/LHS for 15% off your first order + a bonus gift.

Now, most people only think about uric acid if someone has gout. You know—the painful swelling in the big toe that historically was called “the disease of kings.” That was because the kings ate rich food the poor people, who were healthier, couldn't afford the refined food. Now about all of us can eat like kings and that isn't good. According to neurologist and researcher David Perlmutter in his fascinating book Drop Acid, elevated uric acid may be quietly damaging metabolic health long before gout ever develops Uric Acid Secrets

More on “eat the rainbow” . . . or notMedical breakthroughs that we don't really needCan you discuss the order of eating macronutrients and its impact on blood glucose?What about the impact of apple cider vinegar on blood sugar?

We begin our mini-look at Taylor Sheridan's cinematic works with one of his more Western-facing screenplays Hell or High Water. It's an interesting look at violence, poverty, and what one will do for their family in the face of both. Texas Tech's professor of media and communications Dr. David Perlmutter joins the show to talk all about West Texas, the cowboys and Indians of it all, so much more.Become a supporter of this podcast: https://www.spreaker.com/podcast/the-kulturecast--2883470/support.

In this episode, Crawlspace Media's Tim Pilleri & Lance Reenstierna are joined by Dr. Sarah Schiffecker & Dr. David Perlmutter to try to solve the coldest murder in history. The discussion takes them back 5,300 years to the Italian Alps, where the legendary Ötzi became the victim of the worlds oldest documented murder. This conversation centers around questions of motive, means and opportunity. This episode was previously published on Crawlspace on March 29th, 2026. More on Ötzi: https://en.wikipedia.org/wiki/Ötzi. Check out Dr. Schiffecker's work: ⁠⁠⁠https://www.depts.ttu.edu/comc/faculty/faculty/sschiffecker.php⁠⁠⁠ Check out Dr. Perlmutter's work: ⁠⁠⁠⁠⁠https://www.depts.ttu.edu/comc/faculty/faculty/dperlmutter.php⁠⁠⁠⁠ Check out Quince: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://quince.com/MISSING⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Check out Mint Mobile: ⁠⁠⁠⁠⁠⁠mintmobile.com/missing⁠⁠⁠⁠⁠⁠. Main podcast theme by Kevin Macleod. Check out his work at⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠https://incompetech.com/⁠⁠⁠⁠⁠. Additional music by David Williams. See his work at⁠⁠⁠ ⁠⁠http://williamsflutes.com⁠⁠⁠⁠⁠. Follow Missing: IG: ⁠⁠⁠https://www.instagram.com/MissingCSM/⁠⁠⁠. Youtube:⁠⁠⁠⁠ https://www.youtube.com/missingcsm⁠⁠⁠⁠. FB:⁠⁠⁠ https://www.facebook.com/MissingCSM⁠⁠⁠. X:⁠⁠⁠ https://twitter.com/MissingCSM⁠⁠⁠. Spotify:⁠⁠⁠ https://open.spotify.com/show/0yRXkJrZC85otfT7oXMcri⁠⁠⁠. Apple:⁠⁠⁠ https://podcasts.apple.com/us/podcast/missing/id1006974447⁠⁠⁠. Follow Crawlspace: IG:⁠⁠⁠ https://www.instagram.com/Crawlspacepodcast⁠⁠⁠. TT:⁠⁠⁠ https://www.tiktok.com/@crawlspacepodcast⁠⁠⁠. FB:⁠⁠⁠ https://www.facebook.com/Crawlspacepodcast⁠⁠⁠. X:⁠⁠⁠ https://twitter.com/crawlspacepod.⁠⁠⁠ Spotify:⁠⁠⁠ https://open.spotify.com/show/7iSnqnCf27NODdz0pJ1GvJ⁠⁠⁠. Youtube:⁠⁠⁠ https://www.youtube.com/crawlspace⁠⁠⁠. Apple:⁠⁠⁠ https://podcasts.apple.com/us/podcast/crawlspace-true-crime-mysteries/id1187326340⁠⁠⁠. Check out our entire network at⁠⁠⁠ http://crawlspace-media.com/⁠⁠⁠. Learn more about your ad choices. Visit megaphone.fm/adchoices

In this new episode, ⁠Crawlspace Media⁠'s Tim Pilleri and Lance Reenstierna speak with Dr's Sarah Schiffecker and David Perlmutter from Texas Tech University about the mysterious disappearance of Air Force General William Neil McCasland from his home in Albuquerque, New Mexico on February 27th, 2026. If you have any information in General McCasland's disappearance, please text BCSO to 847411 or call 505-468-7070. Dr. Schiffecker's faculty page: https://www.depts.ttu.edu/comc/faculty/faculty/sschiffecker.php. Dr. Perlmutter's faculty page: https://www.depts.ttu.edu/comc/faculty/faculty/dperlmutter.php. Check out Quince: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://quince.com/MISSING⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Check out Mint Mobile: ⁠⁠⁠⁠mintmobile.com/missing⁠⁠⁠⁠. We have an upcoming live show with Another F*cking Horror Podcast! It's called Criminally Stupid - The Search For the World's Dumbest Criminal. For tickets, go to: ⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.eventbrite.com/e/criminally-stupid-the-search-for-the-worlds-dumbest-criminal-tickets-1984625623665⁠⁠⁠⁠⁠⁠⁠⁠. Main podcast theme by Kevin Macleod. Check out his work at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://incompetech.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Additional music by David Williams. See his work at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠http://williamsflutes.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Follow Missing: IG: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/MissingCSM/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. TT:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.tiktok.com/@missingcsm⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. FB:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.facebook.com/MissingCSM⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. X:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://twitter.com/MissingCSM⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Spotify:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://open.spotify.com/show/0yRXkJrZC85otfT7oXMcri⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Youtube:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.youtube.com/missingcsm⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Apple:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://podcasts.apple.com/us/podcast/missing/id1006974447⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Follow Crawlspace: IG:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.instagram.com/Crawlspacepodcast⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. TT:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.tiktok.com/@crawlspacepodcast⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. FB:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.facebook.com/Crawlspacepodcast⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. X:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://twitter.com/crawlspacepod.⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Spotify:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://open.spotify.com/show/7iSnqnCf27NODdz0pJ1GvJ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Youtube:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.youtube.com/crawlspace⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Apple:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://podcasts.apple.com/us/podcast/crawlspace-true-crime-mysteries/id1187326340⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Check out our entire network at⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ http://crawlspace-media.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr is joined by renowned neurologist and bestselling author Dr. David Perlmutter to explore one of the most important breakthroughs in brain health — the role of microglia. Often overlooked, microglial cells are the brain's immune system and play a central role in determining whether the brain thrives or degenerates over time. Dr. Perlmutter explains how these cells can shift between protective (M2) and destructive (M1) states — and how this shift underlies neurodegenerative diseases like Alzheimer's, Parkinson's, and more. Most importantly, this episode highlights how everyday lifestyle choices — from diet and exercise to metabolic health — directly influence brain function and long-term cognitive resilience. Join us as we delve into: What microglia are and why they control brain health The difference between M1 (destructive) and M2 (protective) states How metabolism shapes the brain's immune response Why conditions like Alzheimer's are rooted in immune dysfunction The connection between blood sugar, insulin, and brain degeneration This episode is for you if: You want to protect your brain and prevent cognitive decline You're interested in the science of Alzheimer's and neurodegeneration You want actionable strategies to improve brain health You're curious about the future of brain optimization and longevity You can also find this episode on… Youtube: https://youtu.be/EMrlchMOZKk Find more from Dr. David Perlmutter Website: https://www.drperlmutter.com Book: https://braindefenders.com LinkedIn: https://www.linkedin.com/in/david-perlmutter-md/ Instagram: https://www.instagram.com/davidperlmutter/ Facebook: https://www.facebook.com/DavidPerlmutterMd/ Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ Virtual Symposium 2026: https://homehope.org/homehope-virtual-symposium-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics Find more from Troscriptions Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

Welcome back to Crawlspace. In this new episode, Tim Pilleri & Lance Reenstierna are once again joined by Dr. Sarah Schiffecker & Dr. David Perlmutter. Their conversation takes them back 5,300 years to the Italian Alps, where the legendary Ötzi became the victim of the worlds oldest documented murder. After his discovered in 1991, the questions of motive, means and opportunity remain an elusive enigma. WE HAVE A LIVE SHOW WITH THE SHOW, ANOTHER F*CKING HORROR PODCAST. IT'S CALLED: CRIMINALLY STUPID - THE SEARCH FOR THE WORLDS DUMBEST CRIMINAL. FOR TICKETS, GO TO: ⁠⁠https://www.eventbrite.com/e/criminally-stupid-the-search-for-the-worlds-dumbest-criminal-tickets-1984625623665⁠ Check out Dr. Schiffecker's work: ⁠⁠https://www.depts.ttu.edu/comc/faculty/faculty/sschiffecker.php⁠⁠ Check out Dr. Perlmutter's work: ⁠⁠⁠⁠https://www.depts.ttu.edu/comc/faculty/faculty/dperlmutter.php⁠⁠⁠⁠ Check out Quince: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://quince.com/MISSING⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. The music for Crawlspace was produced by David Flajnik. Listen to his music here: ⁠⁠⁠⁠⁠⁠https://www.pond5.com/artist/bigdsound.⁠⁠⁠⁠⁠ Follow Crawlspace: IG:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.instagram.com/Crawlspacepodcast⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. TT:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.tiktok.com/@crawlspacepodcast⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. FB:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.facebook.com/Crawlspacepodcast⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. X:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://twitter.com/crawlspacepod.⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Spotify:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://open.spotify.com/show/7iSnqnCf27NODdz0pJ1GvJ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Youtube:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.youtube.com/crawlspace⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Apple:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://podcasts.apple.com/us/podcast/crawlspace-true-crime-mysteries/id1187326340⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Follow Missing: IG:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.instagram.com/MissingCSM/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. TT:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.tiktok.com/@missingcsm⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. FB:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.facebook.com/MissingCSM⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. X:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://twitter.com/MissingCSM⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Spotify:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://open.spotify.com/show/0yRXkJrZC85otfT7oXMcri⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Youtube:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.youtube.com/missingcsm⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Apple:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://podcasts.apple.com/us/podcast/missing/id1006974447⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Follow Private Investigations For the Missing Please donate if you can: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://investigationsforthemissing.org/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠http://piftm.org/donate⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://twitter.com/PIFortheMissing⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.facebook.com/PIFortheMissing/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/investigationsforthemissing/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Check out our entire network at⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ http://crawlspace-media.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Learn more about your ad choices. Visit megaphone.fm/adchoices

Welcome back to Crawlspace. In this new episode, Tim Pilleri & Lance Reenstierna are joined by friend of the show, Dr. David Perlmutter and new friend of the show Dr. Sarah Schiffecker. The two break down the nuances of the recent tragedy that occurred near the summit of Austria's highest mountain, Grossglockner. How does a culture rich in climbing and conquering these majestic heights, come to terms with toxic masculinity, national pride and willful neglect? Video of Grossglockner lights courtesy of: ⁠https://www.wcvb.com/article/austria-grossglockner-manslaughter-sentence/70430714⁠ Check out Dr. Schiffecker's work: ⁠https://www.depts.ttu.edu/comc/faculty/faculty/sschiffecker.php⁠ Check out Dr. Perlmutter's work: ⁠⁠⁠https://www.depts.ttu.edu/comc/faculty/faculty/dperlmutter.php⁠⁠⁠ Check out Quince: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://quince.com/MISSING⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. The music for Crawlspace was produced by David Flajnik. Listen to his music here: ⁠⁠⁠⁠⁠https://www.pond5.com/artist/bigdsound.⁠⁠⁠⁠ Follow Crawlspace: IG:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.instagram.com/Crawlspacepodcast⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. TT:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.tiktok.com/@crawlspacepodcast⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. FB:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.facebook.com/Crawlspacepodcast⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. X:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://twitter.com/crawlspacepod.⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Spotify:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://open.spotify.com/show/7iSnqnCf27NODdz0pJ1GvJ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Youtube:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.youtube.com/crawlspace⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Apple:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://podcasts.apple.com/us/podcast/crawlspace-true-crime-mysteries/id1187326340⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Follow Missing: IG:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.instagram.com/MissingCSM/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. TT:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.tiktok.com/@missingcsm⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. FB:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.facebook.com/MissingCSM⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. X:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://twitter.com/MissingCSM⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Spotify:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://open.spotify.com/show/0yRXkJrZC85otfT7oXMcri⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Youtube:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.youtube.com/missingcsm⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Apple:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://podcasts.apple.com/us/podcast/missing/id1006974447⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Follow Private Investigations For the Missing Please donate if you can: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://investigationsforthemissing.org/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠http://piftm.org/donate⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://twitter.com/PIFortheMissing⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.facebook.com/PIFortheMissing/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/investigationsforthemissing/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Check out our entire network at⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ http://crawlspace-media.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Learn more about your ad choices. Visit megaphone.fm/adchoices

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In this new episode, Crawlspace Media's Tim Pilleri & Lance Reenstierna are joined once again by friend of the show and expert in all things media + crime related, Dr. David Perlmutter. As the clock continues to tick on the abduction of Nancy Guthrie, Dr. Perlmutter helps to break down how the media releases information, what is important for the public to know and what's important for the public to not know. If you have any information please submit a tip to the FBI at 1-800-225-5324. You could also submit a tip here: ⁠https://tips.fbi.gov/home⁠. More info: ⁠https://www.fbi.gov/wanted/kidnap/nancy-guthrie⁠. Savannah's Instagram video: ⁠https://www.instagram.com/p/DUW3mpqD8qd⁠. Check out Quince: ⁠⁠⁠⁠⁠⁠⁠https://quince.com/MISSING⁠⁠⁠⁠⁠⁠⁠. Main podcast theme by Kevin Macleod. Check out his work at⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://incompetech.com/⁠⁠⁠⁠⁠⁠. Additional music by David Williams. See his work at⁠⁠⁠⁠ ⁠⁠http://williamsflutes.com⁠⁠⁠⁠⁠⁠. Follow Missing: IG: ⁠⁠⁠⁠https://www.instagram.com/MissingCSM/⁠⁠⁠⁠. TT:⁠⁠⁠⁠ https://www.tiktok.com/@missingcsm⁠⁠⁠⁠. FB:⁠⁠⁠⁠ https://www.facebook.com/MissingCSM⁠⁠⁠⁠. X:⁠⁠⁠⁠ https://twitter.com/MissingCSM⁠⁠⁠⁠. Spotify:⁠⁠⁠⁠ https://open.spotify.com/show/0yRXkJrZC85otfT7oXMcri⁠⁠⁠⁠. Youtube:⁠⁠⁠⁠ https://www.youtube.com/missingcsm⁠⁠⁠⁠. Apple:⁠⁠⁠⁠ https://podcasts.apple.com/us/podcast/missing/id1006974447⁠⁠⁠⁠. Follow Crawlspace: IG:⁠⁠⁠⁠ https://www.instagram.com/Crawlspacepodcast⁠⁠⁠⁠. TT:⁠⁠⁠⁠ https://www.tiktok.com/@crawlspacepodcast⁠⁠⁠⁠. FB:⁠⁠⁠⁠ https://www.facebook.com/Crawlspacepodcast⁠⁠⁠⁠. X:⁠⁠⁠⁠ https://twitter.com/crawlspacepod.⁠⁠⁠⁠ Spotify:⁠⁠⁠⁠ https://open.spotify.com/show/7iSnqnCf27NODdz0pJ1GvJ⁠⁠⁠⁠. Youtube:⁠⁠⁠⁠ https://www.youtube.com/crawlspace⁠⁠⁠⁠. Apple:⁠⁠⁠⁠ https://podcasts.apple.com/us/podcast/crawlspace-true-crime-mysteries/id1187326340⁠⁠⁠⁠. Check out our entire network at⁠⁠⁠⁠ http://crawlspace-media.com/⁠⁠⁠⁠. Learn more about your ad choices. Visit megaphone.fm/adchoices

Welcome back to Crawlspace. In this new episode, Tim Pilleri & Lance Reenstierna are joined once again by friend of the show and expert in all things media + crime related, Dr. David Perlmutter. As the clock continues to tick on the abduction of Nancy Guthrie, Dr. Perlmutter helps to break down how the media releases information, what is important for the public to know and what's important for the public to not know. Nancy Guthrie was taken from her home in Catalina Foothills, Arizona on February 1st, 2026. Nancy is the mother of well known broadcaster Savannah Guthrie. If you have any information please submit a tip to the FBI at 1-800-225-5324. You could also submit a tip here: ⁠⁠https://tips.fbi.gov/home⁠⁠. More info: ⁠⁠https://www.fbi.gov/wanted/kidnap/nancy-guthrie⁠⁠. Savannah's Instagram video: ⁠⁠https://www.instagram.com/p/DUW3mpqD8qd⁠⁠. Check out Quince: ⁠⁠⁠⁠⁠⁠⁠⁠https://quince.com/MISSING⁠⁠⁠⁠⁠⁠⁠⁠. The music for Crawlspace was produced by David Flajnik. Listen to his music here: https://www.pond5.com/artist/bigdsound. Follow Crawlspace: IG:⁠⁠⁠⁠⁠⁠ https://www.instagram.com/Crawlspacepodcast⁠⁠⁠⁠⁠⁠. TT:⁠⁠⁠⁠⁠⁠ https://www.tiktok.com/@crawlspacepodcast⁠⁠⁠⁠⁠⁠. FB:⁠⁠⁠⁠⁠⁠ https://www.facebook.com/Crawlspacepodcast⁠⁠⁠⁠⁠⁠. X:⁠⁠⁠⁠⁠⁠ https://twitter.com/crawlspacepod.⁠⁠⁠⁠⁠⁠ Spotify:⁠⁠⁠⁠⁠⁠ https://open.spotify.com/show/7iSnqnCf27NODdz0pJ1GvJ⁠⁠⁠⁠⁠⁠. Youtube:⁠⁠⁠⁠⁠⁠ https://www.youtube.com/crawlspace⁠⁠⁠⁠⁠⁠. Apple:⁠⁠⁠⁠⁠⁠ https://podcasts.apple.com/us/podcast/crawlspace-true-crime-mysteries/id1187326340⁠⁠⁠⁠⁠⁠. Follow Missing: IG: ⁠⁠⁠⁠⁠https://www.instagram.com/MissingCSM/⁠⁠⁠⁠⁠. TT:⁠⁠⁠⁠⁠ https://www.tiktok.com/@missingcsm⁠⁠⁠⁠⁠. FB:⁠⁠⁠⁠⁠ https://www.facebook.com/MissingCSM⁠⁠⁠⁠⁠. X:⁠⁠⁠⁠⁠ https://twitter.com/MissingCSM⁠⁠⁠⁠⁠. Spotify:⁠⁠⁠⁠⁠ https://open.spotify.com/show/0yRXkJrZC85otfT7oXMcri⁠⁠⁠⁠⁠. Youtube:⁠⁠⁠⁠⁠ https://www.youtube.com/missingcsm⁠⁠⁠⁠⁠. Apple:⁠⁠⁠⁠⁠ https://podcasts.apple.com/us/podcast/missing/id1006974447⁠⁠⁠⁠⁠. Check out our entire network at⁠⁠⁠⁠⁠ http://crawlspace-media.com/⁠⁠⁠⁠⁠. Learn more about your ad choices. Visit megaphone.fm/adchoices

Most brain decline, mood instability, and impulsive behavior start with a breakdown in how the brain's immune cells produce and use energy. This episode shows how mitochondrial health inside microglia influences cognition, emotion, and long-term brain resilience, and how everyday inputs quietly push those systems toward damage or repair. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey is joined by Dr. David Perlmutter, a board-certified neurologist and six-time New York Times bestselling author whose work focuses on the intersection of neurology, nutrition, metabolism, and brain health. A Fellow of the American College of Nutrition and member of the Editorial Board of the Journal of Alzheimer's Disease, Dr. Perlmutter brings decades of clinical and research experience to this conversation on how inflammation and mitochondrial function shape the brain across the lifespan. Together, they explore how microglial cells shift their behavior based on metabolic conditions, and how those shifts influence neurodegeneration, emotional regulation, impulse control, and cognitive performance. The discussion covers real-world inputs that shape these systems, including sleep optimization, fasting, ketosis, glucose regulation, gut signaling, environmental toxins, and tools referenced in the episode such as red and infrared light, 40 Hz light and sound, hyperbaric oxygen, lithium, nicotine, supplements, nootropics, GLP-1 agonists, and dietary approaches like carnivore and ketosis. The conversation connects brain biology to lived experience, showing how metabolism influences behavior, decision making, and long-term human performance through a Smarter Not Harder lens. You'll Learn: • How microglia shift between supportive and destructive states and why metabolism drives that change • How mitochondrial function inside immune cells influences inflammation and brain resilience • How inflammation affects the prefrontal cortex, impulse control, and reward-driven behavior • What the episode says about GLP-1 agonists and behavior changes like reduced cravings and gambling • How gut-derived signaling and short-chain fatty acid balance (butyrate vs propionate) relates to brain function • How tools like red and infrared light, hyperbaric oxygen, and 40 Hz light and sound connect to microglia • The lifestyle levers discussed in the episode: sleep optimization, fasting, ketosis, glucose control, and toxin reduction • The compounds mentioned, including lithium, nicotine, urolithin A, CoQ10, rosmarinic acid, and dihydromyricetin Dave Asprey is a four time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Thank you to our sponsors! KILLSwitch | If you're ready for the best sleep of your life, order now at https://www.switchsupplements.com/ and use code DAVE for 20% off. BodyGuardz | Visit https://www.bodyguardz.com/ and use code DAVE for 25% off. Stop cooking with toxic cookware and upgrade to Our Place today. With a 100-day risk-free trial, plus free shipping and returns, you can experience this game-changing cookware with zero risk. Visit: fromourplace.com/DAVE Use code: DAVE for 10% off sitewide Establish a powerful foundation for sustained wellness with Pique. Unlock 20% off: piquelife.com/DAVE Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: microglia brain health, brain immune system mitochondria, neuroinflammation podcast, mitochondrial dysfunction brain, david perlmutter podcast, dr david perlmutterneurologist, grain brain author podcast, alzheimers brain metabolism, parkinsons microglia, autism brain inflammation, gut brain immune signaling, short chain fatty acids brain, butyrate propionate brain, glp-1 brain behavior, glp-1 addiction research, red light therapy brain, infrared light mitochondria brain, 40 hz light sound brain, hyperbaric oxygen brain health, lithium microglia brain Resources: • Learn More About Dr. Perlmutter at: https://drperlmutter.com/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Join My Low-Oxalate 30-Day Challenge: https://daveasprey.com/2026-low-ox-reset/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com Timestamps: 0:00 - Introduction 1:45 - Autism Spectrum 4:38 - Alzheimer's & Beta Amyloid 7:02 - Brain Immune Cells 8:06 - GLP-1 & Parkinson's 10:44 - M1 vs M2 Microglia 13:08 - Pharmaceutical Microdosing 15:51 - Gene Therapy 19:09 - Mold & Toxins 21:58 - Environmental Pollution 26:05 - MPTP Discovery 29:07 - Healing Interventions 31:39 - Light & Sound Therapy 36:35 - Mitochondrial Function 44:57 - Inflammation & Prefrontal Cortex 48:00 - GLP-1 Global Impact 52:11 - Mitochondrial Community 56:05 - Consciousness & The Field 1:00:00 - Psychedelics 1:01:59 - Love & Judgment 1:06:35 - Death & Knowing 1:09:06 - Heart-Brain Connection 1:11:06 - Closing Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Welcome to Crawlspace. In this new episode, Tim Pilleri & Lance Reenstierna are again joined old friend of the show, Dr. David Perlmutter. The topic this week is trying to understand the killings of Brown University students Mukhammad Aziz Umurzokov and Ella Cook & MIT professor Dr. Nuno Loureiro. Check out Dr. Perlmutter's work: ⁠https://www.depts.ttu.edu/comc/faculty/faculty/dperlmutter.php⁠ Follow Crawlspace: IG:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.instagram.com/Crawlspacepodcast⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. TT:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.tiktok.com/@crawlspacepodcast⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. FB:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.facebook.com/Crawlspacepodcast⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. X:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://twitter.com/crawlspacepod.⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Spotify:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://open.spotify.com/show/7iSnqnCf27NODdz0pJ1GvJ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Youtube:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.youtube.com/crawlspace⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Apple:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://podcasts.apple.com/us/podcast/crawlspace-true-crime-mysteries/id1187326340⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Follow Missing: IG:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.instagram.com/MissingCSM/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. TT:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.tiktok.com/@missingcsm⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. FB:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.facebook.com/MissingCSM⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. X:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://twitter.com/MissingCSM⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Spotify:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://open.spotify.com/show/0yRXkJrZC85otfT7oXMcri⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Youtube:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.youtube.com/missingcsm⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Apple:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://podcasts.apple.com/us/podcast/missing/id1006974447⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Follow Private Investigations For the Missing Please donate if you can: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://investigationsforthemissing.org/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠http://piftm.org/donate⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://twitter.com/PIFortheMissing⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.facebook.com/PIFortheMissing/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/investigationsforthemissing/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Check out our entire network at⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ http://crawlspace-media.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Learn more about your ad choices. Visit megaphone.fm/adchoices

Welcome to Crawlspace. In this new episode, Tim Pilleri & Lance Reenstierna are joined by old friend of the show, Dr. David Perlmutter. The three of them discuss the horrific murders of Rob Reiner and his wife, Michele Singer Reiner at the hands of their son Nick. Dr. Perlmutter is a professor of Media & Communications at Texas Tech University. Check out Dr. Perlmutter's work: https://www.depts.ttu.edu/comc/faculty/faculty/dperlmutter.php Follow Crawlspace: IG:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.instagram.com/Crawlspacepodcast⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. TT:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.tiktok.com/@crawlspacepodcast⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. FB:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.facebook.com/Crawlspacepodcast⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. X:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://twitter.com/crawlspacepod.⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Spotify:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://open.spotify.com/show/7iSnqnCf27NODdz0pJ1GvJ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Youtube:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.youtube.com/crawlspace⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Apple:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://podcasts.apple.com/us/podcast/crawlspace-true-crime-mysteries/id1187326340⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Follow Missing: IG:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.instagram.com/MissingCSM/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. TT:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.tiktok.com/@missingcsm⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. FB:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.facebook.com/MissingCSM⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. X:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://twitter.com/MissingCSM⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Spotify:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://open.spotify.com/show/0yRXkJrZC85otfT7oXMcri⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Youtube:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.youtube.com/missingcsm⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Apple:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://podcasts.apple.com/us/podcast/missing/id1006974447⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Follow Private Investigations For the Missing Please donate if you can: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://investigationsforthemissing.org/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠http://piftm.org/donate⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://twitter.com/PIFortheMissing⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.facebook.com/PIFortheMissing/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/investigationsforthemissing/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Check out our entire network at⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ http://crawlspace-media.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Learn more about your ad choices. Visit megaphone.fm/adchoices