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Your brain is remarkably resilient—but modern life doesn't always make protecting it easy. In Brain Defenders, neurologist David Perlmutter explains how the brain's immune cells can either preserve cognitive health or contribute to decline—and how everyday choices can influence that balance. Then, in Rewired, psychiatrist and neuroscientist Carl Marci explores what smartphones, social media, and nonstop stimulation are doing to our attention, relationships, and emotional well-being.
What if Alzheimer's doesn't begin when you start forgetting names or struggling with memory but decades earlier, when subtle changes are happening in your metabolism, inflammation, and brain? With Alzheimer's in my own family, this conversation with Dr. David Perlmutter felt especially personal. Dr. Perlmutter is a board-certified neurologist, six-time New York Times bestselling author, and one of the leading voices challenging how we think about brain health and cognitive decline. His new book, Brain Defenders, explores emerging research around microglia — the immune cells of the brain — and why they may hold an important key to protecting our brains as we age. We dive into why Dr. Perlmutter believes we need to start thinking about Alzheimer's prevention in our 30s and 40s, the surprising connection between metabolic health and the brain, and how our everyday choices may influence whether our brain's immune cells protect us or work against us. We also get into the role of ultra-processed foods, blood sugar and insulin, the gut microbiome, environmental toxins, sleep, inflammation, mitochondria, vitamin D, and some of the biomarkers Dr. Perlmutter believes are worth knowing. And for women, we explore what happens to the brain during menopause, the latest conversation around estrogen and hormone replacement therapy, and why women face a greater risk of Alzheimer's. Dr. Perlmutter also shares fascinating new research that could change how we think about Alzheimer's, Parkinson's, MS, traumatic brain injury, and other neurological conditions — including why the future of brain health may look very different from the traditional “wait for symptoms, then treat” approach. This episode left me feeling incredibly hopeful about how much influence we may actually have over the future of our brains. If you've ever worried about your memory, your family history, or simply want to stay sharp and resilient as you age, this is a conversation you don't want to miss. Key Moments You'll Love ✨ :
What if the health of your brain decades from now is being shaped by what you are doing today? We tend to think about Alzheimer's and cognitive decline as problems that show up later in life, once memory starts slipping or confusion becomes noticeable. But many of the factors associated with brain decline can begin much earlier. Blood sugar, insulin resistance, sleep, inflammation, muscle mass, exercise, social connection, oral health, and even the medications you regularly take may all influence the environment your brain is aging in. This matters because brain health gives you more areas to act on than most people realize. You can pay attention to metabolic markers before they become major problems, build and preserve muscle, protect your sleep, stay socially connected, take care of your oral microbiome, and understand which emerging therapies actually have evidence behind them. The earlier you start thinking about your brain this way, the more opportunity you have to influence how well it functions later. Dr. David Perlmutter is a board-certified neurologist, six-time New York Times bestselling author, and internationally recognized expert in brain health, nutrition, and neurodegenerative disease. His latest book, Brain Defenders, explores microglia, the brain's immune cells, and how their function may influence conditions including Alzheimer's and Parkinson's. His work focuses on giving people practical ways to protect brain health through metabolism, lifestyle, and emerging neuroscience. What's Discussed: (05:51) What research suggests about slowing or even improving cognitive decline in people already diagnosed with Alzheimer's through intensive lifestyle intervention. (10:47) Why Alzheimer's should not be viewed as purely genetic and how lifestyle and metabolic health can influence risk even when genetic predispositions are present. (12:19) How loneliness and social isolation may affect brain health through stress, cortisol, oxytocin, inflammation, and changes in the brain's immune cells. (20:50) Why the biological conditions associated with cognitive decline may begin in your 40s and 50s, decades before memory problems become obvious. (30:34) How exercise supports the brain through BDNF, irisin, and other chemicals released during muscle activity, and why both cardio and strength training matter. (38:00) Why restorative sleep is an active period for memory consolidation and brain recovery, and how fragmented sleep can undermine brain health even when you spend eight hours in bed. (1:04:34) What the science currently says about NAD, NR, NMN, and IV NAD for mitochondrial function, biological aging, and cognitive health. (1:12:04) How periodontal disease, the oral microbiome, and frequent use of certain antibacterial mouthwashes may affect nitric oxide, metabolism, and long-term brain health. (1:23:05) What emerging research says about GLP-1 drugs for Parkinson's and Alzheimer's, and why using or microdosing them specifically for brain protection is still ahead of the evidence. (1:33:25) Why homocysteine and fasting insulin are two blood markers worth paying attention to when assessing metabolic and long-term brain health. Thank You to Our Sponsors! Magic Mind: Head over to magicmind.com/jen and use code JEN at checkout. Momentous: Ready to try supplements that actually do what they claim? Head to livemomentous.com and use code JEN for 35% off your first subscription. Therasage: Visit therasage.com and use code JEN to get 15% off your order. Your skin Prolon: Prolon is offering listeners 30% off sitewide plus a $40 bonus gift when you subscribe to their 5-Day Program! Just visit prolonlife.com/JENNIFERCOHEN and use code JENNIFERCOHEN to claim your discount and your bonus gift. Tru Niagen®: For supplements that are rigorously tested, third-party verified, and actually deliver what's on the label, head to truniagen.com Find more from Jen Cohen: Website: jennifercohen.com Instagram: @therealjencohen Books: jennifercohen.com/books Speaking: jennifercohen.com/speaking-engagements Find more from Dr. David Perlmutter: Website: drperlmutter.com Instagram: @davidperlmutter Facebook: David Perlmutter M.D. YouTube: @davidperlmutterMD LinkedIn: David Perlmutte, MD Book: Brain Defenders
If you've ever wondered whether your daily habits are quietly protecting your brain, or quietly working against it, this one's for you. Some of the most powerful things you can do for your memory, your focus, and your long-term brain health aren't found in a prescription. They're in your morning coffee, your nightly sleep, and the way you help your body recover every single day.I'm joined by returning guest expert Dr. David Perlmutter, a board-certified neurologist and 6-time New York Times bestselling author, to unpack the real science on the choices that shape cognitive function, metabolism, and longevity. We get into why coffee is so much more than caffeine, how deep sleep literally washes waste out of your brain overnight, why tracking your sleep might be one of the smartest health moves you make, and what the research actually says about infrared saunas, cold plunges, and heart rate variability. It's practical, it's evidence-based, and you can start using it today.What You'll Learn:• Why coffee is far more than caffeine, and the 90-plus bioactive compounds that may help protect your brain• The daily coffee sweet spot, and the "caffeine curfew" that guards your deep sleep• How to choose cleaner coffee: organic, mold-free, water-processed decaf, and why flavored blends are a gamble• Quality over quantity: why "I slept 8 hours" tells you almost nothing about your brain• How deep sleep activates the glymphatic system to wash away waste tied to cognitive decline, and the minimum you should aim for• The everyday habits that quietly sabotage restorative sleep, and why a wearable can help you fix them• What HRV really measures, why higher means more resilient, and simple ways to raise yours• Hot & Cold therapy: What the science says about infrared saunas and cold plunges, and why heat and cold may share the same protective pathways• A crucial caution for breast cancer survivors and anyone at risk for lymphedema before starting heat or cold therapy• The Mouthwash Habit Your Didn't Realize Is Harming You: The surprising connection between your mouth bacteria, mouthwash, blood pressure, and blood sugar• Brain-Boosting Movement: Why exercise acts like medicine, turning your muscles into hormone-producing organs that support your brain...and so much more!About Our Guest Expert:Dr. David Perlmutter is a board-certified neurologist, Fellow of the American College of Nutrition, and 6-time New York Times bestselling author. Recognized as one of the world's leading voices in brain health, he has spent decades translating cutting-edge neuroscience into practical strategies that help people reduce their risk of neurodegenerative disease and support lifelong wellness. He's the author of bestsellers including Grain Brain, Brain Wash, and Drop Acid, with his newest book, Brain Defenders, released in 2026.Connect with Dr. David Perlmutter:Instagram: @davidperlmutterFacebook: Dr. David PerlmutterWebsite: drperlmutter.com_________________________________________Get Cleaner, Regulated, Better Supplements for LessDid your last order of vitamins come off a big online overnight shipping platform but you have no idea how long it was sitting in an overheated warehouse?Or maybe those Omega-3's you take are actually rancid but you wouldn't know?That's why I'm excited to have found a platform that is not only efficacious and 3rd-party lab tested, but also regulated to have the ingredients in them that are on the label!And Fullscript has 100+ brands of supplements you may already be taking…only better. Safer. What your family needs.Yup — your one-stop shop for high-quality wellness and supplement products from brands people actually trust.Better still? I have been able to secure the most awesome discounts for you. Every order. Every day of the year. Even more savings with auto-ship.Whether you're leveling up your health routine, trying to stay consistent, or just attempting to remember to take your vitamins before 11 PM, Fullscript makes the whole process way easier.✨ Easy online ordering✨ Practitioner-trusted supplement brands✨ Personalized wellness support✨ Delivered straight to your door (because leaving the house is optional)Just click HERE to set up a free account. Or visit:https://us.fullscript.com/welcome/samanthaharris_store/store-start_________________________________________Why wash clothes with toxic cleaners? Try this instead!It shocked me that our laundry rooms are often one of the most toxic places in our homes.After breast cancer, I began changing out my personal care and beauty but didn't even think about my cleaning supplies.For laundry, I found a few brands that are really clean and free of harmful ingredients, but still searched for that fresh scent without the toxic junk.Found it finally! Here is the link to it (and you can message me to check to see if there are any great offers happening with current savings!CLICK THIS LINK for the details and get 100 FREE LOADS
Women are far more likely than men to develop Alzheimer's disease, and Dr. David Perlmutter believes one of the most important pieces of that story is metabolic health.In this episode of Live Like a Girl, Dr. Perlmutter joins Dr. Mindy to explain what happens when the brain's immune cells shift from protective to destructive, why menopause may increase vulnerability, and how blood sugar, insulin resistance, visceral fat, inflammation, mitochondrial health, and lifestyle all influence brain aging.They also discuss HRT, GLP-1 medications, ketones, fasting, fiber, exercise, BNDF, sleep, and what women can begin doing in their 30s, 40s, and 50s to support long-term cognitive health.In This Episode, You'll LearnWhy women face a higher risk of Alzheimer'sHow menopause may affect brain metabolismWhy belly fat and insulin resistance matter for brain healthThe blood markers Dr. Perlmutter watches most closelyWhat emerging research says about GLP-1 drugs and the brainThe lifestyle habits Dr. Perlmutter prioritizes for preventionResources MentionedBrain DefendersTanzi StudyCochrane ReviewMore on Dr. David Perlmutterhttps://drperlmutter.com/http://braindefenders.com/https://www.instagram.com/davidperlmutter/https://www.youtube.com/user/DavidPerlmutterMDhttps://x.com/davidperlmutterlinkedin.com/in/david-perlmutter-mdFor more resources related to today's episode, visit the podcast episode page: https://www.drmindypelz.com/ep363/Connect with Dr. Mindy:Join Reset AcademyWatch the episodes on YouTubeFollow Dr. Mindy on InstagramSubscribe to Dr. Mindy's newsletterDisclaimer: This podcast is intended for educational and informational purposes only and is not a substitute for professional medical advice. Always consult a qualified healthcare professional before making changes to your diet, fasting routine, or lifestyle.
By the time memory begins to slip, the changes affecting the brain may have been developing for decades. But the trajectory isn't fixed, and many of the factors driving it are within our control. In this episode, I sit down with my longtime friend and mentor Dr. David Perlmutter, six-time New York Times bestselling author whose new book, Brain Defenders, rethinks what it really takes to protect the brain as we age. You'll learn: Why protecting your brain should begin long before memory problems appear How your daily choices influence whether the brain's immune cells shift into a protective or damaging state Which numbers to know now, including fasting insulin, blood sugar, and waist-to-hip ratio How food, exercise, sleep, gut health, and environmental toxins shape your brain's future What emerging research reveals about slowing—and even improving—cognitive decline I've always appreciated how David's work replaces fear with something far more useful: a clearer understanding of how the choices we make today can help protect our memory, independence, and quality of life for years to come. View Show Notes From This Episode Sign up for Dr. Hyman's Brainshaping Academy to learn how to nourish the biological systems that support your mental, emotional, and cognitive health https://drhyman.com/products/brainshaping?utm_source=dr_hyman_show&utm_medium=newsletter&utm_campaign=may_27&utm_content=link Get Free Weekly Health Tips from Dr. Hyman https://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Sign Up for Dr. Hyman's Weekly Longevity Journal https://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Join the 10-Day Detox to Reset Your Health https://drhyman.com/pages/10-day-detox Join the Hyman Hive for Expert Support and Real Results https://drhyman.com/pages/hyman-hive This episode is brought to you by Paleovalley, Pique, Perfect Amino, BON CHARGE, Cozy Earth, and Fatty15. Shop nutrient-rich foods and supplements at paleovalley.com/hyman and save 15% off your first order. Elevate your daily wellness ritual at piquelife.com/hyman and enjoy 20% off plus free gifts. Help fill protein gaps at bodyhealth.com and use code HYMAN20 for 20% off. Explore red light products at boncharge.com/hyman and enjoy 15% off with code HYMAN. Upgrade your sleep setup with cozyearth.com and enjoy 20% off with code HYMAN. Head to fatty15.com/HYMAN today and use code HYMAN for 15% off your 90-day subscription Starter Kit.
In this episode, neurologist and bestselling author Dr. David Perlmutter, author of Brain Defenders, explains how metabolism, inflammation, microglia, sleep, exercise, diet, and environmental exposures may shape your risk for Alzheimer's and other neurodegenerative diseases.This episode is proudly sponsored by:BUBS Naturals makes my favorite collagen, pure and unflavored, perfect for mixing into any drink, soup, or even recipes! Your hair, skin, and nails will thank you. Visit BUBSNaturals.com and use code GENIUS for 20% off.I sleep on an Avocado mattress because real organic materials, no synthetic shortcuts, and better breathability make a noticeable difference. Go to http://avocadogreenmattress.com/MAX to check out their mattress and bedding sale.ZBiotics Pre-Alcohol Probiotic Drink is the world's first genetically engineered probiotic, designed to help you feel better the day after drinking. Head to https://zbiotics.com/max for 15% off your first order.Kion is known for their transparent and evidence-based essential amino acid (EAA) supplements which help save you calories while providing all essential amino acids for muscle growth and more. Save 20% by going to getkion.com/geniuslife.
Big Pharma bet billions on one theory: clear the amyloid, cure Alzheimer's.A new Cochrane review of 20,000+ patients just proved them wrong — these drugs don't work, and they may be putting your brain at risk. So what's really driving this epidemic?My guest today, six-time New York Times bestselling author and board-certified neurologist Dr. David Perlmutter, says the answer lies in a set of cells most people have never even heard of — and he lays it all out in his new book, Brain Defenders.The good news is, you already have more control over them than any drug could ever give you.We're talking about microglia, the brain's immune cells, and why the choices you make today may matter more than anything a prescription pad can offer.For full show notes and transcript: https://drgundry.com/david-perlmutter-alzheimersOn this episode, you'll learn: All about the new study that found leading Alzheimer's drugs deliver almost no benefit (02:09)Why the so-called enemy in your brain is not what we thought at all (07:34)What microglia are, and why these overlooked immune cells may be the real gatekeepers of your brain's health (05:15)How everyday metabolic issues like blood sugar and insulin resistance can affect your brain (09:30)Why one in nine Americans over 65 is already living with dementia (and most don't know it) (14:08)The surprising connection between Parkinson's, depression, and even autism spectrum conditions (15:11)How THIS lifestyle program helped 70% of Alzheimer's patients stabilize or even improve their cognitive function — no drugs required (17:09)The one mindset shift Dr. Perlmutter says has to happen before any diet or exercise plan will actually work for your brain (22:17)Why getting quality sleep does more for your brain than you think (27:49)The simple blood test you should request NOW to gauge your Alzheimer's risk (33:25)Why women make up two-thirds of Alzheimer's patients (35:29)The critical window for starting hormone replacement therapy (40:08)The truth about antibacterial mouthwash, and why it might be quietly working against your brain health (58:14)A 25-year-old flossing study that predicted exactly what today's top neurology journals are just now confirming (01:00:05)Dr. Perlmutter's honest answer to whether you should take the newer Alzheimer's drugs your doctor may be recommending (01:05:31)More about Dr. David Perlmutter:Dr. David Perlmutter's websiteDr. David Perlmutter's InstagramNew book: Brain Defenders: Harness the Power of Your Immune Cells to Protect Your Brain for Life by Dr. David PerlmutterResearch:Cochrane ReviewTanzi StudyThank you to our sponsors! Check them out: Transform your sleep experience with Cozy Earth bedding. Go to cozyearth.com/gundry for 20% off. Go to thrivemarket.com/GUNDRYPODCAST for 30% off your first order, plus a FREE $60 gift.Go to Quince.com/gundry to upgrade your wardrobe and get free shipping on your orderGet a quote today at Progressive.com.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
In this episode, Dr. Jockers sits down with neurologist and bestselling author Dr. David Perlmutter to explore microglia, the brain's immune cells, and the role they may play in protecting the brain from cognitive decline. You'll learn what can shift these cells from a supportive state toward one that promotes neuroinflammation. Discover why your metabolic health and brain health are deeply connected. Dr. Perlmutter explains how blood sugar, insulin resistance, gut health, and chronic inflammation can influence microglial function and why addressing these factors may be important long before memory problems appear. You'll also hear practical ways to support your brain through exercise, nutrition, sleep, metabolic flexibility, and other daily habits. Dr. Perlmutter shares why protecting your brain isn't just about what happens later in life—and how the choices you make today can help shape your cognitive future. In This Episode: 00:00 Amyloid Myth Busted 00:15 Show Intro and Guest 04:18 Book Inspiration Microglia 06:02 Symptom Care vs Root Cause 09:51 Microglia M1 vs M2 11:15 Gut Brain Inflammation Link 15:01 Metabolism Mirrors Microglia 17:57 Infections Vaccines and Triggers 19:31 CTE Diabetes and Feedforward 25:20 New Tools and Beta Amyloid Drugs 30:37 Cochrane Verdict Drugs Fail 33:28 Lifestyle Trial Reverses Decline 38:23 Microglia Lifestyle Levers 39:07 Exercise Myokines Brain Boost 42:20 Alzheimers Risk Epigenetics 45:12 Imaging Microglia TSPO 46:24 Fasting Ketones Brain Fuel 49:45 MCT Oil Memory Care 51:16 POINTER Lifestyle Trial 55:57 Fiber Polyphenols Foods 58:34 Supplements DHA Vitamin D 01:02:23 Key Labs Glucose Tau 01:06:19 Prevention Mission Wrap 01:07:43 Final Thanks Outro Enjoy a clean, protein-packed snack with PaleoValley's Grass-Fed Beef Sticks. Made without sugar, additives, or preservatives, they're packed with healthy fats and grass-fed nutrients to help curb cravings, support steady energy, and keep you satisfied on the go. Save 15% with code DRJOCKERS at paleovalley.com/drjockers. Give your hair and skin routine an upgrade with iRestore's advanced red light therapy devices. The iRestore Elite combines 300 lasers and 200 LEDs to support thicker, healthier-looking hair, while the cordless Illumina Face Mask uses triple-wavelength light therapy to target fine lines, breakouts, and dullness. Take advantage of iRestore's Labor Day savings and huge discounts at iRestore.com and use promo code DRJOCKERS to save. Stop guessing about your health and start understanding what's happening inside your body with Superpower Health. One simple blood draw measures 100+ biomarkers covering your heart, liver, thyroid, hormones, metabolism, vitamins, minerals, and environmental toxins, plus you'll get ongoing tracking and access to a clinician team. Head to Superpower.com and use promo code JOCKERS to get $20 off your membership for a limited time. Support your joints, hair, nails, skin, and recovery with BUBS Naturals Collagen Peptides, a tasteless, odorless formula that mixes easily into coffee, smoothies, or juice. It has zero sugar, sweeteners, or fillers and is third-party tested, NSF Certified for Sport, Whole30 Approved, and sustainably sourced from grass-fed, pasture-raised cattle. Head to BUBSNaturals.com and use promo code DRJOCKERS to get 20% off for a limited time. "Exercise isn't just changing your body. It's changing the environment inside your brain." Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean TuneIn Radio Resources: Enjoy 15% off grass-fed beef sticks with code DRJOCKERS at paleovalley.com/drjockers. Go to iRestore.com and use promo code DRJOCKERS Visit Superpower.com and use promo code JOCKERS to get $20 off Visit BUBSNaturals.com and use promo code DRJOCKERS to get 20% off Connect with Dr. David Perlmutter: Book - https://a.co/d/06cRZKlT Website - https://drperlmutter.com/ Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https:/www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/ If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/
For so many people, the thought of memory loss or cognitive decline feels frightening. But today's guest shares an empowering message: there is so much we can do through our daily choices to support brain health and reduce risk. I'm joined by Dr. David Perlmutter, board-certified neurologist, leading brain health expert, and bestselling author of Brain Defenders, to discuss what we can do today to protect our brains as we age. We explore the important shift in how we understand brain health, looking at the bigger picture of immunometabolism, metabolic health, inflammation, and the environment that influences the brain long before symptoms appear. Dr. Perlmutter explains why habits that support the entire body, including blood sugar balance and reduced inflammation, can also support cognitive health. He also shares exciting areas of research and reminds us that even small changes can create meaningful improvements over time. Just like we can take steps to support our bones, we can also support our brains through the choices we make every day. "Your brain's destiny is in your hands. It's based upon the choices that you are going to make every single day. A cure for dementia is not going to be given to you in the form of a medication." ~ Dr. David Perlmutter In this episode: - [03:22] - The new science of brain health and immunometabolism - [11:19] - Metabolic health and its impact on cognitive decline - [17:26] - Blood sugar, insulin resistance, and brain health - [28:35] - How to protect your brain as you age - [31:37] - Lab tests for proactive brain health - [39:15] - Environmental toxins, plastics, and brain health - [45:26] - Emerging therapies and the future of brain protection - [52:08] - Resources from Dr. Perlmutter Resources - Osteoporosis Exercises to Strengthen Your Bones and Prevent Fractures - https://tinyurl.com/mystrongbonesexercises - Dr. Perlmutter's new book, Brain Defenders - https://drperlmutter.com/books/brain-defenders/ - Dr. Perlmutter's website - https://drperlmutter.com/ More about Margie - Website - https://margiebissinger.com/ - Facebook - https://www.facebook.com/p/Margie-Bissinger-MS-PT-CHC-100063542905332/ - Instagram - https://www.instagram.com/margiebissinger/?hl=en DISCLAIMER – The information presented on this podcast should not be construed as medical advice. It is not intended to replace consultation with your physician or healthcare provider. The ideas shared on this podcast are the expressed opinions of the guests and do not always reflect those of Margie Bissinger and Happy Bones, Happy Life Podcast. *In compliance with the FTC guidelines, please assume the following about links on this site: Some of the links going to products are affiliate links of which I receive a small commission from sales of certain items, but the price is the same for you (sometimes, I even get to share a unique discount with you). If I post an affiliate link to a product, it is something that I personally use, support, and would recommend. I personally vet each and every product. My first priority is providing valuable information and resources to help you create positive changes in your health and bring more happiness into your life. I will only ever link to products or resources (affiliate or otherwise) that fit within this purpose.
Episode Highlights With DavidWhy living an adventurous lifestyle is so good for your brain and bodyBeing sedentary is one of the biggest things that threatens brain health- here's whyWhy he considers brain defenders the most urgent and important thing he's ever writtenWhat the brains immune system is and why this is vital to understanding long term brain healthMicroglial cells and why these matterWhy it isn't just about beta amyloid plaques for alzheimer's and why this thinking was harmfulThe reason many drugs designed to address alzheimer's are not just ineffective but dangerousHow one study showed completely stopping the decline of alzheimer's with lifestyle intervention and actually showed improvementNurturing mitochondrial function helps the brain support M2 cells that are protectiveBrain metabolism mirrors the body's metabolism and how being metabolically healthy protects the brainEven one night of non-restorative sleep can impact the brainExercise is a tonic for the brain and bathes the brain in protective compoundsHow to protect the brain from the problems of less sleep even postpartum (there is an amazing built in protective mechanism from oxytocin)Why this means human connection is brain protective as well and community matters for brain healthWhat the latest research says about statins and what we need to understand His take one gamma light, olfactory signaling and hyperbaric for brain healthResources MentionedBrain Defenders: Harness the Power of Your Immune Cells to Protect Your Brain for Life by David Perlmutter, MDBrain Maker: The Power of Gut Microbes to Heal and Protect Your Brain for Life by David Perlmutter, MDGrain Brain: The Surprising Truth about Wheat, Carbs, and Sugar--Your Brain's Silent Killers by David Perlmutter, MDJaspr Air FilterLMNTI talk often about the health benefits of salt and electrolytes and I am a big fan of LMNT canned drinks and packets. Go to drinklmnt.com/wellnessmana for a special offer.HiyaHiya created a super powered chewable vitamin for kids that packs twelve organic fruits and vegetables plus fifteen essential vitamins and minerals into every dose. Try it at hiyahealth.com/wellnessmama.
Dr. David Perlmutter — neurologist, New York Times bestselling author, and author of the new book Brain Defenders — joins Dr. Will Cole to reveal what he believes is the most important breakthrough in brain health science in decades: the microglial cell. He explains why the amyloid hypothesis that has dominated Alzheimer's research (and pharmaceutical spending) for 30 years has been definitively disproven by a Cochrane analysis, why a Harvard lifestyle study arrested Alzheimer's decline in 70% of patients without any drug, and what the April 2024 NEJM GLP-1 Parkinson's trial means for the future of neurodegenerative disease. They also cover the practical daily habits, foods, supplements, and lab tests that shift the brain's immune cells from destructive to protective — and why you are far more the architect of your brain's destiny than anyone has told you. For all links mentioned in this episode, visit http://www.drwillcole.com/podcastPlease note that this episode may contain paid endorsements and advertisements for products and services. Individuals on the show may have a direct or indirect financial interest in products or services referred to in this episode.Sponsors:Take the first step and learn at a pace that works for you. Visit WaldenU.edu.Give them meals + snacks that are actually right for where kids are developmentally - balanced, intentional and made to support real growth. Go to littlespoon.com/WILLCOLE and enter code WILLCOLE for 30% off your first order.Get a free 8-count Sample Pack of LMNT's most popular drink mix flavors with any purchase at drinklmnt.com/artofbeingwell. Find your favorite flavor, or share with a friendQUINCE.COM/WILLCOLE for free shipping and 365 day returns. Now available in Canada too! www.jshealthvitamins.com code WILLCOLE for 15% off at checkout LIFT Oléoactif® significantly reduced the primary wrinkle by more than 200%.† OR 200% reduction in wrinkles with LIFT Oléoactif®†* Disclaimer: *Clinical test: LIFT Oléoactif® in cream, results in 28 days, compared to placebo. LIFT Oléoactif® is a trademark of HALLSTAR FRANCE SAS. 95% see a reduction in eyebag volume* with Eyeseryl® Peptide Disclaimer: *Clinical test: EYESERYL® Peptide in cream, results in 28 days. EYESERYL® Peptide is a trademark of Lubrizol Advanced Materials, Inc. or its affiliates.Produced by Dear Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
“We can choose our brain's destiny,” says David Perlmutter, MD. Perlmutter is a Board-Certified Neurologist and six-time New York Times bestselling author whose work focuses on the intersection of neurology, nutrition, and brain health. He is on the Board of Directors of the American College of Nutrition and the Editorial Board of the Journal of Alzheimer's Disease. His books, including the #1 bestseller Grain Brain, has been published in 32 languages and sold over a million copies. Perlmutter lectures globally at leading institutions and has been featured on major media outlets including 20/20, CNN, The Today Show, and Oprah. His new book, Brain Defenders, focuses on the pivotal role of microglia, the brain's immune cells, in protecting, repairing, and reprogramming the brain for lifelong resilience, and is now available for pre-order. 00:00 - Treating the symptoms, not the cause 02:37 - Microglial cells & their evil twin state 05:44 - How metabolism affects the brain 08:00 - Gut bacteria, inflammation, & brain degeneration 11:38 - Why lifestyle beats the APOE4 gene 16:25 - Perlmutter's daily routine 23:55 - Loneliness & oxytocin 26:21 - The effects of long COVID on the brain 32:18 - Glyphosate & other environmental factors 39:20 - Reprogramming microglia & mitochondrial transplants 41:35 - Own your brain's destiny Referenced in the episode: For more about Perlmutter, visit his website: https://drperlmutter.com/ Alzheimers & UPFs study: https://doi.org/10.1016/j.tjpad.2024.100042 POINTER study - https://jamanetwork.com/journals/jama/fullarticle/2837046 20-week Alzheimer's study: https://link.springer.com/article/10.1186/s13195-024-01482-z Golf course & Parkinson's study: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2833716 We hope you enjoy this episode, and feel free to watch the full video on YouTube! Whether it's an article or podcast, we want to know what we can do to help here at mindbodygreen. Let us know at: podcast@mindbodygreen.com. Learn more about your ad choices. Visit megaphone.fm/adchoices
Dr. David Perlmutter is a Board-Certified Neurologist and six-time New York Times bestselling author whose work focuses on the intersection of neurology, nutrition, and brain health. A Fellow of the American College of Nutrition, he serves on its Board of Directors and on the Editorial Board of the Journal of Alzheimer's Disease. His books, including the #1 bestseller Grain Brain, have been published in 32 languages and sold over a million copies. Dr. Perlmutter lectures globally at leading institutions and has been featured on major media outlets including 20/20, CNN, The Today Show, and Oprah. His contributions have earned him numerous national and international awards for clinical innovation and leadership. Today on the show, we discuss why Alzheimer's may be driven more by lifestyle than genetics, how insulin resistance and blood sugar can quietly damage the brain, the foods and eating habits that may protect cognitive health, why sleep, exercise, and social connection are critical for preventing decline, what caffeine, nicotine, marijuana, and alcohol actually do to the brain, and the simple changes you can start making today to protect your memory for decades to come. Thank you to today's sponsor: Momentous Try Momentous Signature Spec Creatine: https://www.livemomentous.com Use code ADVERSITY for up to 35% off your entire first order Learn more about your ad choices. Visit megaphone.fm/adchoices
In this episode of Resiliency Radio with Dr. Jill, Dr. Jill Carnahan welcomes renowned neurologist and bestselling author Dr. David Perlmutter to explore the emerging science behind brain health, neuroinflammation, and cognitive resilience. Drawing from his groundbreaking new book, Brain Defenders, Dr. Perlmutter explains how microglia—the brain's immune cells—play a central role in protecting or damaging the brain depending on our metabolism, lifestyle, and environment. Together they discuss why Alzheimer's and Parkinson's disease begin decades before symptoms appear, why inflammation and insulin resistance are major drivers of neurodegeneration, and what we can do today to protect lifelong brain health. Whether you're concerned about memory loss, dementia prevention, or optimizing cognitive performance, this episode offers science-backed strategies to build a healthier, more resilient brain.
In this episode, we sit down with neurologist Dr. David Perlmutter to explore the fascinating science behind optimal brain health. We dive deep into topics from microglial cells and immunometabolism to the importance of addressing root causes like lifestyle and diet for preventing neurodegenerative diseases.Dr. David Perlmutter shares his journey into integrative neurology, emphasizing how metabolic health, inflammation, and stress impact brain function. The conversation covers practical insights on how dietary choices, exercise, sleep, and stress management can maintain cognitive vitality and longevity. Groundbreaking concepts like biological aging, mitochondrial health, and the latest research on treatments and prevention round out an empowering and thought-provoking discussion.Ready to take control of your brain's future? Listen in, share this episode with three friends, and start applying these empowering insights to upgrade your health. Don't forget to check out Dr. Perlmutter's new book, Brain Defenders, for deeper guidance. Dr. Navaz HabibEmail: podcast@healthupgraded.comFacebook: https://www.facebook.com/DrNavazHabib/Instagram: https://www.instagram.com/drnavazhabib/LinkedIn: https://ca.linkedin.com/in/drnavazhabibJP ErricoInstagram: https://www.instagram.com/thevnsguy/LinkedIn: https://www.linkedin.com/in/jp-errico-097629aaDr. David PerlmutterWebsite: https://drperlmutter.com/Books: https://drperlmutter.com/books/
In this episode of Revolution Health Radio, Chris Kresser sits down with renowned neurologist and bestselling author Dr. David Perlmutter to discuss the emerging science of microglia—the brain's immune cells—and why they may hold the key to preventing cognitive decline and Alzheimer's disease. Drawing from his new book, Brain Defenders, Dr. Perlmutter explains how lifestyle factors such as nutrition, exercise, sleep, metabolic health, and gut health influence whether microglia protect the brain or contribute to chronic inflammation and neurodegeneration. Together, they challenge the outdated notion that dementia is largely predetermined by genetics, highlighting growing evidence that proactive lifestyle interventions can preserve—and even improve—brain function throughout life. The post RHR: Why Microglia Are the Key to Brain Health, with Dr. David Perlmutter appeared first on Chris Kresser.
Dr. David Perlmutter is a board-certified neurologist and New York Times bestselling author known for his work on brain health.Show partners:LMNT - Claim your free LMNT Sample Pack with any purchase by using this linkJaspr - Save $200 off your Jaspr air scrubber by using this linkShow notes:jessechappus.com/717
In this new episode, Crawlspace Media's Tim Pilleri and Lance Reenstierna speak with Professor and Dr. David Perlmutter of Texas Tech University about the mysterious disappearance of Liz Waddell from Grand Anse Beach, St. George, Grenada on Wednesday, July 22, 2026. If you have any information in the disappearance of Liz Waddell please call 1-473-444-4454. Find Liz official site: https://findliz.com/. Please share any information, no matter how small, with the proper authorities or email tips@findliz.com. Check out Quince: https://quince.com/MISSING. Check out Mint Mobile: mintmobile.com/missing. Check out Kensington Publishing: https://www.kensingtonbooks.com. Main podcast theme by Kevin Macleod. Check out his work at https://incompetech.com/. Additional music by David Williams. See his work at http://williamsflutes.com. Follow Missing: IG: https://www.instagram.com/MissingCSM/. Youtube: https://www.youtube.com/missingcsm. FB: https://www.facebook.com/MissingCSM. X: https://twitter.com/MissingCSM. Spotify: https://open.spotify.com/show/0yRXkJrZC85otfT7oXMcri. Apple: https://podcasts.apple.com/us/podcast/missing/id1006974447. Follow Crawlspace: IG: https://www.instagram.com/Crawlspacepodcast. TT: https://www.tiktok.com/@crawlspacepodcast. FB: https://www.facebook.com/Crawlspacepodcast. X: https://twitter.com/crawlspacepod. Spotify: https://open.spotify.com/show/7iSnqnCf27NODdz0pJ1GvJ. Youtube: https://www.youtube.com/crawlspace. Apple: https://podcasts.apple.com/us/podcast/crawlspace-true-crime-mysteries/id1187326340. Check out our entire network at http://crawlspace-media.com/. Learn more about your ad choices. Visit megaphone.fm/adchoices
Alzheimer's disease has grown to become the most common form of dementia, and as of now, there is no cure for this devastating neurodegenerative disease. But new science shows that your brain's immune cells play an essential role in how your brain ages. Today, you're going to learn this latest science and how to put it into action. Today's guest, Dr. David Perlmutter is a board-certified neurologist and six-time New York Times bestselling author. His new book, Brain Defenders, dives into the groundbreaking discovery that immune cells in the brain are the key to brain health and longevity. On this episode, you're going to learn about this emerging science and what you can do to protect your brain now and as you age. In this interview, you're going to learn about the fascinating science of immunometabolism, what microglial cells are, and the specific lifestyle habits that can shape the future of your brain. We're going to talk about specific foods and exercises that can dictate the health of your brain's immune cells, and proven strategies to protect your brain from degradation. Enjoy! In this episode you'll discover: The one fundamental mechanism that connects all neurodegenerative diseases. (2:26) What the latest science says about the efficacy of Alzheimer's medications. (3:41) The essential function of microglial cells. (6:51) What immunometabolism is. (8:41) How having type 2 diabetes can increase your risk of Alzheimer's disease. (11:23) What GLP-1 drugs teach us about the link between the brain and metabolism. (12:12) How exercise helps defend the brain from degeneration. (29:12) The connection between myokines and metabolism. (29:54) Why flexibility and balance training are important for longevity. (36:57) The truth about fish oil supplements for brain health. (38:14) What to eat to defend your brain. (42:21) How eating ultraprocessed foods increases your risk of brain diseases. (45:38) Why stress impacts your brain health. (57:10) The simplest way to measure your health and activity levels. (1:08:23) Items mentioned in this episode include: DrinkLMNT.com/model - Get a truly meaningful dose of electrolytes in a science-backed ratio. Free sample pack with any order. Organifi.com/Model - Organifi makes nutrition easy and delicious for everyone. Take 20% off your order with the code MODEL. Brain Defenders by Dr. David Perlmutter - Preorder your copy of Dr. Perlmutter's new book today! Grain Brain by Dr. David Perlmutter - Read about how your diet affects your brain health! You've Been Pooping All Wrong by Dr. Trisha Pasricha - Learn about gut health and how to poop better! Connect with Dr. David Perlmutter Website / Podcast / Facebook / Instagram Be sure you are subscribed to this podcast to automatically receive your episodes: Apple Podcasts Spotify Soundcloud Pandora YouTube This episode of The Model Health Show is brought to you by LMNT and Organifi. Most people are underhydrated—and it's costing you energy, focus, and performance. LMNT delivers a science-backed electrolyte ratio with no sugar, no junk—just what your body actually needs. Get a free sample pack with any order at drinklmnt.com/model. Make nutrition effortless—and actually enjoyable. Organifi's delicious, superfood blends help you boost energy, reduce stress, and feel your best every day. Get 20% off with code MODEL at organifi.com/model.
Alzheimer's isn't just a diagnosis that shows up in old age. It's a slow metabolic unraveling that can start decades before the first symptom. In this episode, Jeff sits down with Dr. David Perlmutter, a board-certified neurologist and author of the new book Brain Defenders (out August 18), to unpack what's really driving Alzheimer's and other neurodegenerative diseases. They get into the brain's own immune system, the microglial cells that either protect or destroy your neurons, and why the beta-amyloid hypothesis may have sent decades of research down the wrong path. Why microglia, not amyloid plaques, may be the true driver of brain degeneration The link between insulin resistance, blood sugar, and neuroinflammation How the gut microbiome and oral health shape the brain's immune response Practical diet, sleep, and supplement strategies to protect your brain starting now This episode is for anyone who wants to understand Alzheimer's prevention before symptoms start, and for the millions currently caring for a parent or partner facing cognitive decline. Preorder Dr. David Perlmutter's new book “Brain Defenders” at braindefenders.com. This episode was made possible by: CocoaVia:. Use code COMMUNE2026 for 25% off at CocoaVia.com LMNT: Get a free 8-count Sample Pack of LMNT's most popular drink mix flavors with any purchase at drinklmnt.com/commune. Stemregen: Get 20% off your first order at stemregen.co/commune with the code COMMUNEPOD Vivobarefoot: Try Vivobarefoot risk-free with a 100-day return guarantee, and get 25% off your order at vivobarefoot.com/commune. Stripes: Visit stripesbeauty.com and use the code COMMUNE20 for 20% off our entire product line.
While it may be simplistic to say that the Blackberry died at the hands of the iPhone, it wouldn't be entirely inaccurate. That death, however, was a very beautiful corpse as one might imagine due to Blackberry device becoming so ubiqutous as to have a nickname: "Crackberry". Join Chris, Dr. David Perlmutter, and Mark Stachiw as they talk all about the film as well as the history surrounding it and much more.Become a supporter of this podcast: https://www.spreaker.com/podcast/the-kulturecast--2883470/support.
In this new episode, Crawlspace Media's Tim Pilleri and Lance Reenstierna discuss the mysterious death of Austria's Christian Pilnacek in October of 2023 with Dr.'s Sarah Schiffecker and David Perlmutter from Texas Tech University. Christian Pilnacek was a prominent Austrian lawyer and former judge who rose to become one of the most powerful officials in the country's Ministry of Justice before being suspended amid controversy. While his October 2023 death in a Danube tributary was quickly ruled a suicide, the circumstances remain surrounded by mystery due to allegations of a sloppy investigation and suspected political interference. Check out Dr. Schiffecker's work: https://www.depts.ttu.edu/comc/faculty/faculty/sschiffecker.php. Check out Dr. Perlmutter's work: https://www.depts.ttu.edu/comc/faculty/faculty/dperlmutter.php. Check out Quince: https://quince.com/MISSING. Check out Mint Mobile: mintmobile.com/missing. Check out Kensington Publishing: https://www.kensingtonbooks.com. Main podcast theme by Kevin Macleod. Check out his work at https://incompetech.com/. Additional music by David Williams. See his work at http://williamsflutes.com. Follow Missing: IG: https://www.instagram.com/MissingCSM/. Youtube: https://www.youtube.com/missingcsm. FB: https://www.facebook.com/MissingCSM. X: https://twitter.com/MissingCSM. Spotify: https://open.spotify.com/show/0yRXkJrZC85otfT7oXMcri. Apple: https://podcasts.apple.com/us/podcast/missing/id1006974447. Follow Crawlspace: IG: https://www.instagram.com/Crawlspacepodcast. TT: https://www.tiktok.com/@crawlspacepodcast. FB: https://www.facebook.com/Crawlspacepodcast. X: https://twitter.com/crawlspacepod. Spotify: https://open.spotify.com/show/7iSnqnCf27NODdz0pJ1GvJ. Youtube: https://www.youtube.com/crawlspace. Apple: https://podcasts.apple.com/us/podcast/crawlspace-true-crime-mysteries/id1187326340. Check out our entire network at http://crawlspace-media.com/. Learn more about your ad choices. Visit megaphone.fm/adchoices
Neurologist and bestselling author Dr. David Perlmutter returns to discuss the groundbreaking science behind his new book, Brain Defenders. Together, we unpack why Alzheimer's disease may be driven less by amyloid plaques and more by chronic inflammation, metabolic dysfunction, and changes in the brain's immune cells. Dr. Perlmutter explains the critical role of microglia, how blood sugar and insulin resistance affect the brain, why gut health is directly connected to cognitive function, and what lifestyle habits have the strongest evidence for protecting memory as we age. → Leave Us A Voice Message! Topics Discussed: → What causes Alzheimer's disease? → How do you prevent Alzheimer'? → What foods improve brain health? → Can inflammation cause dementia? → Does blood sugar affect memory? Sponsored By: → Function | Check your health the way I do. Function provides 160+ lab tests for $1/day and member pricing on advanced imaging. Join at https://functionhealth.com/bewellbykelly and use code BEWELL25 for a $25 credit. → Be Well By Kelly Protein Powder & Essentials | Get $10 off your order with PODCAST10 at https://bewellbykelly.com. → Shop minnow's new apré-ski capsule collection at https://shopminnow.com and enter code MEETMINNOW15 at checkout to receive 15% off your first order. → LMNT | Get a free 8-count Sample Pack of LMNT's most popular drink mix flavors with any purchase at https://drinklmnt.com/Kelly. Find your favorite LMNT flavor, or share with a friend. → Branch Basics | Go to https://branchbasics.com/BEWELLPODCAST and use code: BEWELLPODCASTfor 15% off your first purchase. Timestamps: → 00:00:00 - Introduction → 00:03:07 - Why Alzheimer's Research Is Changing → 00:05:42 - Microglia Explained → 00:10:44 - Understanding Immunomatabolism → 00:15:10 - Insulin Resistance + "Type 3 Diabetes" → 00:19:27 - Long COVID + Brain Recovery → 00:30:20 - Lifestyle Changes For Brain Health → 00:35:22 - The Gut Microbiome → 00:37:27 - Tracking Gut Health → 00:39:26 - Early Biomarkers/Testing → 00:45:20 - Exercise + Muscle → 00:49:51 - Children's Nutrition → 00:52:48 - Women's Dementia Risk → 00:58:53 - GLP1s + Other Peptides → 01:07:41 - Dr. Perlmutter's Daily Brain Health Routine Further Listening: → Nutrition for a Healthy Brain & Body (Without Counting Calories) | Max Lugavere Check Out David: → Book | Braindefenders.com → Website → Instagram Check Out Kelly: → Instagram → Youtube → Facebook
Neurologist Dr. David Perlmutter Explains Brain Inflammation and Alzheimer's Risk Your brain has its own immune system, and when it turns against you, it becomes the hidden driver behind Alzheimer's, Parkinson's, depression, and even long COVID. This episode hands you the science to recognize it early and reverse it. Get Dr. Perlmutter's new book Brain Defenders: https://drperlmutter.com/books/brain-defenders/ Host Dave Asprey sits down with Dr. David Perlmutter, a board-certified neurologist and six-time New York Times bestselling author whose work sits at the intersection of neurology, nutrition, and brain health. He is a Fellow of the American College of Nutrition, serves on its Board of Directors, and sits on the Editorial Board of the Journal of Alzheimer's Disease. His books, including the number one bestseller Grain Brain, span 32 languages and have sold over a million copies, and his upcoming release, Brain Defenders, explores the pivotal role of microglia, the brain's immune cells, in protecting, repairing, and reprogramming the brain for lifelong resilience. Dave and Dr. Perlmutter break down how microglia, the brain's resident immune cells, shift from a supportive state into a destructive one called M1, and why this shift, not amyloid plaque, may be the real driver of Alzheimer's, Parkinson's, and other neurodegenerative conditions. They dig into why the leading amyloid-clearing drugs fail to improve cognition, what a landmark JAMA study revealed about reversing cognitive decline through lifestyle intervention alone, and why a single daily serving of ultra-processed food raised Alzheimer's risk by 13 percent in a 12.7 year study. They also cover new research on GLP-1 drugs and brain inflammation, the surprising role of gum disease and oral bacteria in dementia risk, and why 40 hertz light therapy is emerging as a low-cost tool for clearing brain plaque and calming neuroinflammation. You'll Learn: Why the shift from supportive to destructive brain immune cells may be the true root cause of Alzheimer's and Parkinson's Why leading Alzheimer's drugs fail to improve cognition, and what the original research behind the amyloid hypothesis actually showed How one daily serving of ultra-processed food raises Alzheimer's risk, and what a landmark lifestyle intervention study found instead Whether GLP-1 drugs help or harm brain inflammation, based on new Parkinson's and Alzheimer's trial data How gum disease and oral bacteria are linked to dementia, and simple daily habits that reduce that risk Why 40 hertz light therapy is emerging as a tool to clear brain plaque and calm neuroinflammation How ketones, DHA, and metabolic health protect the brain after head injury Thank you to our sponsors! - Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com. - ZenBud | Dave's Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount. - Pique | Head over to Piquelife.com/Dave to get 20% off your order. That's P-I-Q-U-E life dot com slash DAVE - PredictiveMind™ | Get your Brain Pattern Mapping report at predictivemind.io/dave and use code DAVE for 10% off. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: microglia, brain inflammation, Alzheimer's prevention, Parkinson's disease, amyloid hypothesis, neurodegeneration, GLP-1 drugs, semaglutide, ultra-processed food, gum disease and dementia, oral microbiome, 40 hertz light therapy, ketones, DHA, mitochondria, brain fog, long COVID, David Perlmutter, Brain Defenders, Grain Brain, functional medicine, biohacking, longevity, neuroplasticity Resources: • Get Dr. Perlmutter's New Book Brain Defenders: https://drperlmutter.com/books/brain-defenders/ • Learn More About Dr. Perlmutter's Work At: https://drperlmutter.com/ • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15? • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 00:40 – Intro 02:38 – Ultra-Processed Foods 06:34 – Are Carbs Bad? 08:48 – Alcohol & Brain Health 12:28 – Microglia & Inflammation 24:37 – Head Injury & Recovery 29:27 – Oral Bacteria & Dementia 34:08 – GLP-1s & Brain Inflammation 40:20 – 40 Hertz Light Therapy 48:35 – Air Pollution vs. Lead 50:27 – David's Closing Truth See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Immune Regulation, Omega-3 Nuance, and Himalayan Tartary Buckwheat with Dr. Austin Perlmutter, chief science officer of Big Bold Health. He details immune regulation as a nuanced, multidimensional system shaped by diet and lifestyle rather than simple “boosting.” Perlmutter explains Big Bold Health's focus on immunometabolism, educating about immune complexity, and conducting studies on nutraceuticals, including use of CGMs and clinical trials. He discusses why eating fish often outperforms refined fish-oil supplements, noting conventional processing (heat, bleaching, deodorizing, esterification) and loss of other lipids and nutrients. Perlmutter highlights specialized pro-resolving mediators (resolvins, protectins, maresins) and vitamins A and D as potentially better preserved in minimally processed oils, and reviews typical omega-3 intake and target ranges. The conversation also covers immunosenescence/inflammaging and Big Bold Health research on sprouted Himalayan Tartary Buckwheat, its high polyphenols (rutin, quercetin), microbiome effects, and studies including epigenetic aging clocks and brain outcomes.
In this new episode, Crawlspace Media's Tim Pilleri and Lance Reenstierna speak with Dr.'s Sarah Schiffecker and David Perlmutter about the media circus surrounding the Karen Read case. In this episode, we explore the complex case of Karen Reed, media coverage, and the impact of technology on justice. Our experts discuss media circus, social media influence, and the evolving standards of evidence in criminal justice. Check out Dr. Schiffecker's work: https://www.depts.ttu.edu/comc/faculty/faculty/sschiffecker.php. Check out Dr. Perlmutter's work: https://www.depts.ttu.edu/comc/faculty/faculty/dperlmutter.php. Check out Quince: https://quince.com/MISSING. Check out Mint Mobile: mintmobile.com/missing. Check out Kensington Publishing: https://www.kensingtonbooks.com. Main podcast theme by Kevin Macleod. Check out his work at https://incompetech.com/. Additional music by David Williams. See his work at http://williamsflutes.com. Follow Missing: IG: https://www.instagram.com/MissingCSM/. Youtube: https://www.youtube.com/missingcsm. FB: https://www.facebook.com/MissingCSM. X: https://twitter.com/MissingCSM. Spotify: https://open.spotify.com/show/0yRXkJrZC85otfT7oXMcri. Apple: https://podcasts.apple.com/us/podcast/missing/id1006974447. Follow Crawlspace: IG: https://www.instagram.com/Crawlspacepodcast. TT: https://www.tiktok.com/@crawlspacepodcast. FB: https://www.facebook.com/Crawlspacepodcast. X: https://twitter.com/crawlspacepod. Spotify: https://open.spotify.com/show/7iSnqnCf27NODdz0pJ1GvJ. Youtube: https://www.youtube.com/crawlspace. Apple: https://podcasts.apple.com/us/podcast/crawlspace-true-crime-mysteries/id1187326340. Check out our entire network at http://crawlspace-media.com/. Learn more about your ad choices. Visit megaphone.fm/adchoices
The Love, Happiness and Success Podcast With Dr. Lisa Marie Bobby
Here's something I keep seeing in my office that almost nobody has language for. Your body and your nervous system run on completely different timelines. Your labs can be clear. Your divorce can be final. Your treatment can be done. And your nervous system can still be living inside the chapter you just survived, because nothing about getting through a hard thing actually tells your body it is safe to stop bracing. In this episode, I sit down with Amy Kurtz, the patient advocate who spent close to two decades trying to figure out why her body kept shutting down on her. Amy is a Hachette author whose new book But You Look Fine launches the day after this episode airs, and she coined a phrase for the exact experience I just described. She calls it Medical Trauma Brain. Her message has been endorsed by Mark Hyman, her own physician, and by David Perlmutter, Kris Carr, and Sharon Salzberg. After 36 doctors and a late-stage neurological Lyme diagnosis at 35, she didn't just heal physically. She figured out the part nobody warned her about. The part that comes after. In This Episode The exact phrase Amy's husband said in their kitchen that finally named what she could not name herself Why the gap between "you should be fine now" and "I do not feel fine" is not a personal failing Why this pattern is not just for chronic illness, it shows up after divorce, postpartum, fertility, caregiving, and any long hard chapter The five non-negotiables Amy now uses to decide whether a doctor is worth her time Why women carry this harder than men, both clinically and culturally What active movement actually does for an overstimulated nervous system (it is more than you think) The one tool Amy would give a woman tonight who is recognizing herself for the first time How to stay connected to the people you love when you are the person who is not okay This episode is for anyone who has technically gotten through something hard and quietly cannot understand why she still does not feel like herself. The illness that finally has a diagnosis. The divorce that is actually final. The postpartum body that healed on paper. The job she finally left. The caregiver who buried the person she was caring for and woke up the next morning still bracing. If you have been told you should be fine by now, and you are not, this conversation is going to give you language for what is actually happening in your body and a way forward that respects the timeline. Episode Breakdown: 00:02:04 The Gap Between Sick and Well Nobody Warned You About 00:05:10 36 Doctors and One Diagnosis: Amy's Story 00:13:25 What Is Medical Trauma Brain? 00:14:54 Why Your Body Still Doesn't Feel Safe (Even Though You're Fine) 00:21:05 How to Advocate for Yourself in a System That Won't 00:45:03 How to Regulate Your Nervous System After Trauma or Illness 00:51:01 The Wider Lens: Why This Isn't Just About Illness 00:56:00 The One Tool I'd Give a Woman Tonight Resources: Read the full article on this conversation, including everything we mentioned and where to find Amy's work Wondering what is keeping you stuck? Take our free What's Holding You Back quiz Ready to talk to someone about what you are carrying? Book a free consultation If a friend has been telling you she is fine and you can tell she is not, send her this episode. She will be glad you did. XO, Dr. Lisa Marie Bobby Growing Self Special thanks to this month's sponsors of the podcast: Upwork — When you need specialized talent fast, Upwork gives you access to vetted professionals across 125+ categories, from marketing to web development to operations support. No long recruiting cycles. No guesswork. Just the right person, when you need them. Check it out at upwork.com — posting a job is free. Shopify — The all-in-one platform for building and growing your online business. Visit shopify.com/lhs to explore their tools and access exclusive listener discounts. OSEA — Amazing, clean, science-backed skincare made with the power of the sea. Use code LHS at oseamalibu.com for 10% off your first order. LNutra Prolon — A science-backed, plant-based nutrition program that supports fat loss, metabolism, cellular rejuvenation, and overall longevity. Head to ProlonLife.com/LHS for 15% off your first order + a bonus gift.
Now, most people only think about uric acid if someone has gout. You know—the painful swelling in the big toe that historically was called “the disease of kings.” That was because the kings ate rich food the poor people, who were healthier, couldn't afford the refined food. Now about all of us can eat like kings and that isn't good. According to neurologist and researcher David Perlmutter in his fascinating book Drop Acid, elevated uric acid may be quietly damaging metabolic health long before gout ever develops Uric Acid Secrets
More on “eat the rainbow” . . . or notMedical breakthroughs that we don't really needCan you discuss the order of eating macronutrients and its impact on blood glucose?What about the impact of apple cider vinegar on blood sugar?
We begin our mini-look at Taylor Sheridan's cinematic works with one of his more Western-facing screenplays Hell or High Water. It's an interesting look at violence, poverty, and what one will do for their family in the face of both. Texas Tech's professor of media and communications Dr. David Perlmutter joins the show to talk all about West Texas, the cowboys and Indians of it all, so much more.Become a supporter of this podcast: https://www.spreaker.com/podcast/the-kulturecast--2883470/support.
In this episode, Crawlspace Media's Tim Pilleri & Lance Reenstierna are joined by Dr. Sarah Schiffecker & Dr. David Perlmutter to try to solve the coldest murder in history. The discussion takes them back 5,300 years to the Italian Alps, where the legendary Ötzi became the victim of the worlds oldest documented murder. This conversation centers around questions of motive, means and opportunity. This episode was previously published on Crawlspace on March 29th, 2026. More on Ötzi: https://en.wikipedia.org/wiki/Ötzi. Check out Dr. Schiffecker's work: https://www.depts.ttu.edu/comc/faculty/faculty/sschiffecker.php Check out Dr. Perlmutter's work: https://www.depts.ttu.edu/comc/faculty/faculty/dperlmutter.php Check out Quince: https://quince.com/MISSING. Check out Mint Mobile: mintmobile.com/missing. Main podcast theme by Kevin Macleod. Check out his work at https://incompetech.com/. Additional music by David Williams. See his work at http://williamsflutes.com. Follow Missing: IG: https://www.instagram.com/MissingCSM/. Youtube: https://www.youtube.com/missingcsm. FB: https://www.facebook.com/MissingCSM. X: https://twitter.com/MissingCSM. Spotify: https://open.spotify.com/show/0yRXkJrZC85otfT7oXMcri. Apple: https://podcasts.apple.com/us/podcast/missing/id1006974447. Follow Crawlspace: IG: https://www.instagram.com/Crawlspacepodcast. TT: https://www.tiktok.com/@crawlspacepodcast. FB: https://www.facebook.com/Crawlspacepodcast. X: https://twitter.com/crawlspacepod. Spotify: https://open.spotify.com/show/7iSnqnCf27NODdz0pJ1GvJ. Youtube: https://www.youtube.com/crawlspace. Apple: https://podcasts.apple.com/us/podcast/crawlspace-true-crime-mysteries/id1187326340. Check out our entire network at http://crawlspace-media.com/. Learn more about your ad choices. Visit megaphone.fm/adchoices
In this new episode, Crawlspace Media's Tim Pilleri and Lance Reenstierna speak with Dr's Sarah Schiffecker and David Perlmutter from Texas Tech University about the mysterious disappearance of Air Force General William Neil McCasland from his home in Albuquerque, New Mexico on February 27th, 2026. If you have any information in General McCasland's disappearance, please text BCSO to 847411 or call 505-468-7070. Dr. Schiffecker's faculty page: https://www.depts.ttu.edu/comc/faculty/faculty/sschiffecker.php. Dr. Perlmutter's faculty page: https://www.depts.ttu.edu/comc/faculty/faculty/dperlmutter.php. Check out Quince: https://quince.com/MISSING. Check out Mint Mobile: mintmobile.com/missing. We have an upcoming live show with Another F*cking Horror Podcast! It's called Criminally Stupid - The Search For the World's Dumbest Criminal. For tickets, go to: https://www.eventbrite.com/e/criminally-stupid-the-search-for-the-worlds-dumbest-criminal-tickets-1984625623665. Main podcast theme by Kevin Macleod. Check out his work at https://incompetech.com/. Additional music by David Williams. See his work at http://williamsflutes.com. Follow Missing: IG: https://www.instagram.com/MissingCSM/. TT: https://www.tiktok.com/@missingcsm. FB: https://www.facebook.com/MissingCSM. X: https://twitter.com/MissingCSM. Spotify: https://open.spotify.com/show/0yRXkJrZC85otfT7oXMcri. Youtube: https://www.youtube.com/missingcsm. Apple: https://podcasts.apple.com/us/podcast/missing/id1006974447. Follow Crawlspace: IG: https://www.instagram.com/Crawlspacepodcast. TT: https://www.tiktok.com/@crawlspacepodcast. FB: https://www.facebook.com/Crawlspacepodcast. X: https://twitter.com/crawlspacepod. Spotify: https://open.spotify.com/show/7iSnqnCf27NODdz0pJ1GvJ. Youtube: https://www.youtube.com/crawlspace. Apple: https://podcasts.apple.com/us/podcast/crawlspace-true-crime-mysteries/id1187326340. Check out our entire network at http://crawlspace-media.com/. Learn more about your ad choices. Visit megaphone.fm/adchoices
In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr is joined by renowned neurologist and bestselling author Dr. David Perlmutter to explore one of the most important breakthroughs in brain health — the role of microglia. Often overlooked, microglial cells are the brain's immune system and play a central role in determining whether the brain thrives or degenerates over time. Dr. Perlmutter explains how these cells can shift between protective (M2) and destructive (M1) states — and how this shift underlies neurodegenerative diseases like Alzheimer's, Parkinson's, and more. Most importantly, this episode highlights how everyday lifestyle choices — from diet and exercise to metabolic health — directly influence brain function and long-term cognitive resilience. Join us as we delve into: What microglia are and why they control brain health The difference between M1 (destructive) and M2 (protective) states How metabolism shapes the brain's immune response Why conditions like Alzheimer's are rooted in immune dysfunction The connection between blood sugar, insulin, and brain degeneration This episode is for you if: You want to protect your brain and prevent cognitive decline You're interested in the science of Alzheimer's and neurodegeneration You want actionable strategies to improve brain health You're curious about the future of brain optimization and longevity You can also find this episode on… Youtube: https://youtu.be/EMrlchMOZKk Find more from Dr. David Perlmutter Website: https://www.drperlmutter.com Book: https://braindefenders.com LinkedIn: https://www.linkedin.com/in/david-perlmutter-md/ Instagram: https://www.instagram.com/davidperlmutter/ Facebook: https://www.facebook.com/DavidPerlmutterMd/ Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ Virtual Symposium 2026: https://homehope.org/homehope-virtual-symposium-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics Find more from Troscriptions Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products
While it may not have won Best Picture or Best Actress at the most recent Academy Awards, Bugonia was not only one of the best films of the last year but also one of the most thought-provoking. Featuring Emma Stone and Jesse Plemons, the film is a character study as well as being a musing on the state of the world and the way humans have left it. Professor of Media and Communications Dr. David Perlmutter joins the show to talk all about the wild film.Become a supporter of this podcast: https://www.spreaker.com/podcast/the-kulturecast--2883470/support.
Welcome back to Crawlspace. In this new episode, Tim Pilleri & Lance Reenstierna are once again joined by Dr. Sarah Schiffecker & Dr. David Perlmutter. Their conversation takes them back 5,300 years to the Italian Alps, where the legendary Ötzi became the victim of the worlds oldest documented murder. After his discovered in 1991, the questions of motive, means and opportunity remain an elusive enigma. WE HAVE A LIVE SHOW WITH THE SHOW, ANOTHER F*CKING HORROR PODCAST. IT'S CALLED: CRIMINALLY STUPID - THE SEARCH FOR THE WORLDS DUMBEST CRIMINAL. FOR TICKETS, GO TO: https://www.eventbrite.com/e/criminally-stupid-the-search-for-the-worlds-dumbest-criminal-tickets-1984625623665 Check out Dr. Schiffecker's work: https://www.depts.ttu.edu/comc/faculty/faculty/sschiffecker.php Check out Dr. Perlmutter's work: https://www.depts.ttu.edu/comc/faculty/faculty/dperlmutter.php Check out Quince: https://quince.com/MISSING. The music for Crawlspace was produced by David Flajnik. Listen to his music here: https://www.pond5.com/artist/bigdsound. Follow Crawlspace: IG: https://www.instagram.com/Crawlspacepodcast. TT: https://www.tiktok.com/@crawlspacepodcast. FB: https://www.facebook.com/Crawlspacepodcast. X: https://twitter.com/crawlspacepod. Spotify: https://open.spotify.com/show/7iSnqnCf27NODdz0pJ1GvJ. Youtube: https://www.youtube.com/crawlspace. Apple: https://podcasts.apple.com/us/podcast/crawlspace-true-crime-mysteries/id1187326340. Follow Missing: IG: https://www.instagram.com/MissingCSM/. TT: https://www.tiktok.com/@missingcsm. FB: https://www.facebook.com/MissingCSM. X: https://twitter.com/MissingCSM. Spotify: https://open.spotify.com/show/0yRXkJrZC85otfT7oXMcri. Youtube: https://www.youtube.com/missingcsm. Apple: https://podcasts.apple.com/us/podcast/missing/id1006974447. Follow Private Investigations For the Missing Please donate if you can: https://investigationsforthemissing.org/. http://piftm.org/donate. https://twitter.com/PIFortheMissing. https://www.facebook.com/PIFortheMissing/. https://www.instagram.com/investigationsforthemissing/. Check out our entire network at http://crawlspace-media.com/. Learn more about your ad choices. Visit megaphone.fm/adchoices
We're joined by Dr. David Perlmutter of Perlmutter Eye Center. Ray Graf hosts.
Big unga bunga energy abound on this episode of the Kulturecast, Chris is joined by Dr. David Perlmutter and Richard Hatem of Richard Hatem's Paranormal Bookshelf to talk all about Otzi the Iceman and a story told in a dead language all about him: Iceman (2017). If you're not a fan of dialogue and cavemen, this is the film for you.Become a supporter of this podcast: https://www.spreaker.com/podcast/the-kulturecast--2883470/support.
Welcome back to Crawlspace. In this new episode, Tim Pilleri & Lance Reenstierna are joined by friend of the show, Dr. David Perlmutter and new friend of the show Dr. Sarah Schiffecker. The two break down the nuances of the recent tragedy that occurred near the summit of Austria's highest mountain, Grossglockner. How does a culture rich in climbing and conquering these majestic heights, come to terms with toxic masculinity, national pride and willful neglect? Video of Grossglockner lights courtesy of: https://www.wcvb.com/article/austria-grossglockner-manslaughter-sentence/70430714 Check out Dr. Schiffecker's work: https://www.depts.ttu.edu/comc/faculty/faculty/sschiffecker.php Check out Dr. Perlmutter's work: https://www.depts.ttu.edu/comc/faculty/faculty/dperlmutter.php Check out Quince: https://quince.com/MISSING. The music for Crawlspace was produced by David Flajnik. Listen to his music here: https://www.pond5.com/artist/bigdsound. Follow Crawlspace: IG: https://www.instagram.com/Crawlspacepodcast. TT: https://www.tiktok.com/@crawlspacepodcast. FB: https://www.facebook.com/Crawlspacepodcast. X: https://twitter.com/crawlspacepod. Spotify: https://open.spotify.com/show/7iSnqnCf27NODdz0pJ1GvJ. Youtube: https://www.youtube.com/crawlspace. Apple: https://podcasts.apple.com/us/podcast/crawlspace-true-crime-mysteries/id1187326340. Follow Missing: IG: https://www.instagram.com/MissingCSM/. TT: https://www.tiktok.com/@missingcsm. FB: https://www.facebook.com/MissingCSM. X: https://twitter.com/MissingCSM. Spotify: https://open.spotify.com/show/0yRXkJrZC85otfT7oXMcri. Youtube: https://www.youtube.com/missingcsm. Apple: https://podcasts.apple.com/us/podcast/missing/id1006974447. Follow Private Investigations For the Missing Please donate if you can: https://investigationsforthemissing.org/. http://piftm.org/donate. https://twitter.com/PIFortheMissing. https://www.facebook.com/PIFortheMissing/. https://www.instagram.com/investigationsforthemissing/. Check out our entire network at http://crawlspace-media.com/. Learn more about your ad choices. Visit megaphone.fm/adchoices
Life 3 Years After Stroke: Three years ago, Pete Rumple was in a hospital bed, weighing 337 pounds, unable to walk, unable to talk, and completely paralysed down his right side following a massive hemorrhagic stroke. He was on 17 medications and had just spent his first night as a wheelchair user. By his own admission, the first year was so dark that he didn’t want to live. Today, Pete does CrossFit every day, has lost 150 pounds, is off 15 of his 17 medications, and is about to launch a new business at 61 years old. This is what life 3 years after a stroke can look like and, more importantly, how Pete got there. The First Decision: Control What You Can Within days of his stroke, while still in the hospital, Pete made a choice. He couldn’t walk. He couldn’t use his right arm. Doctors were managing everything around him. But he could control one thing: what he ate. “I got to change everything,” he says. “And as I lay there, this was one thing I could control with all the things I couldn’t.” Pete reduced his intake to two or three bites of food per day. By the time he left the hospital 30 days later, he had lost 40 pounds. That single decision became the foundation of everything that followed. For anyone newly out of the hospital and feeling overwhelmed, this is perhaps the most important message: you don’t have to fix everything at once. Find one controllable. Start there. Books like Grain Brain by Dr David Perlmutter and Why We Get Sick by Benjamin Bikman are excellent starting points for understanding the role of nutrition in brain recovery; both are recommended in this episode. Movement: From Water to CrossFit Pete’s physical recovery moved in deliberate stages. With right-side proprioception severely affected, his body couldn’t properly sense where it was in space land-based exercise felt impossible at first. The solution was water. “The water surrounds you,” Pete explains. “It’s easier to move with what we both have.” He spent nearly a year in the pool doing aquatic therapy, then transitioned to a gym with a personal trainer for four months, then, in April 2024, ditched his cane and started CrossFit. He now attends every day, with about 30% modification. The journey from wheelchair to CrossFit wasn’t fast, and it wasn’t linear. But it was intentional. The Brain Science Behind Doing Hard Things One of the most fascinating parts of Pete’s recovery is how he used neuroscience to drive his progress. After watching a Huberman Lab episode featuring David Goggins, he learned about the anterior mid-cingulate cortex (AMCC), a region of the brain that grows and strengthens specifically when you do things that are difficult and unpleasant. “Everything I did not enjoy or created pain, I’m doing it.” This wasn’t masochism. It was a strategy. Pete began deliberately choosing the exercises, behaviours, and tasks he least wanted to do and watched his recovery accelerate as a result. His speech improved. His movement improved. His cognitive function came back faster. Bill adds important context here: when you visualise movement, your brain fires the same neural pathways as when you physically perform it. Pete used this daily, studying his CrossFit workout the night before, visualising each exercise, then arriving 30 minutes early to breathe and mentally rehearse before training. This is neuroplasticity working for you, not against you. The choice is yours: choose the hard that rewards you, or endure the hard that doesn’t. Identity: Three Words That Changed Everything Beyond the physical, Pete’s recovery demanded a complete rebuild of who he was. An executive career was gone. Independence had been stripped away. The personality and habits that contributed to the stroke, such as overworking, overeating, and using alcohol to manage stress, needed to be replaced, not just removed. He approached this the way he’d approached business: with a framework. At any given time, Pete identifies three words that define who he is. Right now: resilient, consistent, and unafraid. “I try to be honest with myself and say, where am I now?” he explains. “And it may change, but it gives me something to triangulate toward.” This kind of identity-based self-management, knowing who you are deciding to be, not just what you are trying to do, is one of the most transferable lessons from Pete’s story. What Life 3 Years After Stroke Really Looks Like Pete’s neurologist, who once saw him quarterly, recently told him she doesn’t need to see him annually anymore. “We have not seen this kind of recovery before from what you had,” she said. He’s about to start a fractional leadership business with a former CFO. He does CrossFit every day. He sleeps well. He volunteers. He uses AI tools to stay sharp and curious. He is, as he puts it, “on the other side of it.” But he’s also clear-eyed about what’s ahead: returning to high-stakes work, managing the stressors that contributed to his stroke in the first place, and monitoring the potholes that come with re-entering a demanding professional world. “I realise that is a very real risk,” he says. “I’m going to test and learn.” The Lily Pad Principle When asked how to frame the journey for people still in the early stages, Pete offers one of the most useful images in this entire conversation: “It’s like lily pads across the lake. Get to a lily pad, then get to the next one. Don’t worry about boiling the ocean. Don’t worry about what it’s going to be in months or a year. Step by step. Keep pushing.” That is life 3 years after stroke, not a finish line, but a direction. And for Pete Rumple, the direction is forward. Want more stories like this? Read Bill’s book recoveryafterstroke.com/book | Support the show: patreon.com/recoveryafterstroke Disclaimer This blog is for informational purposes only and does not constitute medical advice. Please consult your doctor before making any changes to your health or recovery plan. From Wheelchair to CrossFit: Life 3 Years After a Massive Hemorrhagic Stroke Pete Rumple lost 150 lbs, ditched the wheelchair, and now does CrossFit at 61. Here’s what life 3 years after a stroke really looks like. Turnto.ai InterviewPeter Rumple Interview EP 332Turnto.ai discount code: Bill10Highlights: 00:00 Introduction to Life 3 Years After Stroke Recovery Journey05:31 Physical Recovery and Rehabilitation11:05 Dietary Changes and Weight Loss15:42 Medication Management and Health Improvements21:29 The Role of Visualisation in Recovery26:03 Embracing Discomfort for Growth33:31 The Power of Hard Work and Persistence40:53 The Journey Back to Work50:48 Navigating Health Challenges56:25 Resilience and Consistency in Recovery01:04:38 Proactive Health Management01:15:11 Defining Identity Through Resilience Transcript: Introduction to Life 3 Years After Stroke Recovery Journey Pete Rumple (00:00)And Bill, I want to take a second and plug your book back in the first ⁓ the first session I did with you, I referenced a number of things you taught me through the podcast that I did to make to start building momentum like the cooking dinner every day was the to do. That was your mission. Yeah. so much of what I’ve learned from you, the podcast and what’s inevitably in the book was a great starting point for me. And I built my, my stuff on top of it, but it was really great to stand on your shoulders and get, and get that lift. Bill Gasiamis (00:44)Hi everyone, before we get into Pete’s story and you are definitely going to want to hear this one. I want to share something I’ve been using myself that I genuinely think could help a lot of you. It’s called turn2.ai and it’s an AI health sidekick that keeps you up to date with personalized updates every single week. Did you know there were over 800 new things published every week related to stroke? Research, expert discussions. patient stories, clinical trials, events. It’s an enormous amount of information. Turn2 finds what’s most relevant to you and delivers it straight to your inbox. I use it myself and it’s genuinely my favorite tool for 2026 for staying across what’s new in stroke recovery. It’s low cost and completely patient first. You can try it for free. And when you’re ready to subscribe, you can use my code, BILL10, at turn2.ai slash sidekick slash stroke to get a discount. I earn a small commission if you use that link at no extra cost to you. And that helps keep this podcast going. Also, if you haven’t yet, pick up a copy of my book, head to recoveryafterstroke.com/book. Real stories, real tools. The same stuff Pete and I talk about today and a huge thank you to everyone supporting us on Patreon and in the other ways that you support the show and myself. You’re the reason this content stays free for the people who need it You can support the show at patreon.com/recoveryafterstroke. Right. Let’s get into Pete Rumple’s story. Massive hemorrhagic stroke. Wheelchair couldn’t walk or talk 337 pounds three years later. He does CrossFit every day So you’re gonna want to hear this one. Let’s get into it Bill Gasiamis (02:35)Pete Rumpel, hello, welcome back. Pete Rumple (02:38)Hey Bill, it’s great to see you again. Bill Gasiamis (02:41)Great to see you too, my friend. ⁓ Last time we met was about a year ago. And this is gonna be a slightly different episode because we’re gonna talk about what things were like then and then what they’re like now, just so that we can paint a picture for people about how recovery has gone, what happened in the last 12 or so months. And in the previous episode, by the way, that was episode… 338 or something. And now we’re nearing episode 394, 395. will be. So I’ve been pretty consistent. So it means that it’s been over a year because I try and release one episode a week, et cetera. So it’d be a really good thing to do for people is to give them a bit of a guide of. some of the setbacks, some of the challenges, some of the things that have changed, improved. And now everyone’s different, okay? So this is Pete’s version. And what we’re hoping to do is kind of inspire hope, Pete, right? We wanna give people hope that things can change and improve. And even if it’s slower for you than other people, there can be a reward for putting in a lot of effort, hard work, re-educating yourself about what it means to live healthily. and all that kind of thing. And give us just a little bit of an insight because there’ll be a link to the original video where you can find out Pete’s complete story, but give us a little bit of an insight into the stroke, the day that it happened, what it was like. Pete Rumple (04:24)Okay, you bet Bill it was about 38 months ago. The stroke, was, it was a massive hemorrhagic stroke. ⁓ eight months in a wheelchair had to learn to talk again, walk again, all that. And, ⁓ so we had, ⁓ had the call about a little over a year and a half through it. And then, ⁓ now I’m further through it and, it’s gone amazing. I’m so lucky. So whatever we want to dig into that’ll be great. Bill Gasiamis (05:04)So your deficits were your right arm wasn’t working properly. Initially you weren’t able to walk. You were wheelchair bound for nearly six months. ⁓ So what are the physical deficits like now? What has changed? What has improved? And how did that go? what were the things that you did that helped you improve in that way? Physical Recovery and Rehabilitation Pete Rumple (05:31)Yeah. So Bill, I, um, it was my right side that I lost, which I forget what the term is, but, uh, it was my whole right side. So, um, when I, what, what I did that was important is first of all, totally overhauled my diet. And I, um, I had lost about 150 pounds. Um, I then, when I started about a year into it, I started, um, doing aquatics, the water aerobics to start dealing with their proprioception and the, um, and just movement. couldn’t, I couldn’t do that in, the ether. I couldn’t do it in the air. had to do it with the water. Bill Gasiamis (06:27)Okay, why is that? Because that’s interesting, because I have a similar problem with proprioception. My left side kind of doesn’t know where it is. There’s not enough information telling it where it is. And sometimes it overcompensates and I get off balance, etc. It feels strange. In the water, I also calmly, I felt calmly different, like I felt ⁓ more supported, even though the water wasn’t really supporting me. How was it for you? Pete Rumple (06:56)You’re absolutely right, Bill, because the water surrounds you, right? So it’s easy to move in the water with what we both have. So I spent almost a year in the water. then I started to, then what I did is I moved to a gym with someone helping me work out for about four months. And then in April, so almost a year ago, in April, I got rid of my cane and I went to CrossFit. And so now I do CrossFit every day. And that was really ugly at first, Bill, and I had to do a lot of modification. But now I modify probably 30%. But Bill Gasiamis (07:42)Uh-huh. Pete Rumple (07:54)row bike. can’t run yet. I’m still walking, but I’m getting ready to go to the beach and practice running for about a month. Bill Gasiamis (08:05)Okay, where in the head was the hemorrhagic stroke? Where did it happen? Do you know? Pete Rumple (08:14)The where, ⁓ I forget. Bill Gasiamis (08:18)That’s all right. It’s not important to remember. So also then, ⁓ when you had the hemorrhagic stroke, how was it rectified or resolved? Did they operate? What did they do? Pete Rumple (08:30)They didn’t have to operate. Bill Gasiamis (08:32)Uh-huh. Pete Rumple (08:33)They just, I got in there, they did things to make sure the bleeding stopped, ⁓ but it was no operation. Bill Gasiamis (08:45)what caused the bleed? Was it ⁓ high blood pressure as a result of your weight? Pete Rumple (08:50)It was a number of things, was high blood pressure, it was a lot of stress. They have a scale bill called the Holmes Raw Scale, Holmes with an L and Raw, R-A-H-E, where you can, it has like 42 major stress events. If you score under 150, you’re fine, 150, 300s. pretty bad and then over 300 is devastating like it’s predicts a major stroke or heart attack within a year. And I was 360 on that scale. I’d gone through the divorce, I had the kids, I had a job change, you name it, I had it. ⁓ Weight was not good, drank too much. So that was my wake up call. if you will, which was severe. And it’s been, it’s great now. Bill Gasiamis (09:53)Yeah, so your arm was completely flaccid, I think, when we spoke last. So where is it now? Pete Rumple (10:03)I can do everything with it. This is the, so I can lift and I’m lifting more weight, not where I was, but about probably 50%. I’m doing pull-ups with the arm and my legs are, I’ve worked them a lot. I’m very strong there. So it’s getting there. Bill Gasiamis (10:25)Okay, cool. When we spoke, you mentioned that in hospital alone, you’d lost 40 pounds. That kind of makes sense. A lot of people say that things change in hospital food relation. When you’re unwell, ⁓ how you consume food completely changes, as well as how hospitals ⁓ treat people with regards to the food, how it’s terrible, how often you get to eat. and how accessible it is. So, but earlier, a little earlier, you said that you lost 150 pounds all up. Dietary Changes and Weight Loss Pete Rumple (11:05)Yeah, Bill. So when I was in the hospital, which was obvious, I was there 30 days from the stroke. And that was where I had to make a choice. And it was like, if am I going to try and get better or not. And so what I did is I ate two to three bites of food a day. That was it because I was in a wheelchair, Bill, I couldn’t move. So coming out 40 pounds lighter was ⁓ a lot of work and a lot of fasting, if you will. Bill Gasiamis (11:42)Why did you decide that that was what you needed to do? How did you conclude that? I know I’m gonna be in hospital. I’ve had a hemorrhagic stroke. There’s nothing else I can do. What I’m gonna do is fast and stop eating food. How does that? Pete Rumple (12:01)was a first step, Bill. Absolutely. was like, I got to change everything. And so as I lay here, this is one thing I can control with all the things I can’t. Bill Gasiamis (12:14)In hospital though, most people in hospital don’t have that realization. I mean, that would have been days out from a hemorrhagic stroke. They’re telling you all these things. Like how did you get to that conclusion? Were you cognizant of needing to do that earlier before you got sick and then you thought, well, now I have to do it or was it an aha moment of some other kind? Pete Rumple (12:40)No, you’re absolutely right. And it was something I knew was getting out of control, Bill. And I couldn’t, I couldn’t resolve it. It was just, it was really tough. And I’m like, this is it. I mean, this is the ultimate wake up call. The other one, Bill, was I had, when I came into the hospital, I was on 17 meds. I now have two. and I’m at 20 milligrams and I’m probably off those in the next four to five months. So it’s been a long programmatic diet, nutrition, health, and it’s been three years. I mean, it’s not insignificant for sure. Bill Gasiamis (13:27)⁓ What was the 17 medications treating or or or managing? Pete Rumple (13:37)I think Bill, it’s almost like, like, what do you do with this guy? You got to throw everything at him to keep on going. I don’t think it would have been 17 for very long. It was probably stop gap measures. Some were pain, but even the pain bill second day. I said, I want no more pain meds, take them away. And it was brutal, right? Cause you know, the way you feel and the, my scapula, my legs, was, it was awful, but I was like, I found my way here, I got to find my way out and let me get off as much as I can and start the pilgrimage back. Bill Gasiamis (14:20)Before the stroke, would you have been somebody who would have taken a device to change your diet? Pete Rumple (14:28)I would have taken every hack I could have, Bill, before the stroke. Bill Gasiamis (14:34)Anything to avoid doing the hard work? that what you mean? Yes. Pete Rumple (14:38)Yes, sir. And look, I was always a hard worker. And I would work out and do stuff. But this is a whole other level. This became life or death. I mean, because you know, the stats bill, like, when I looked at the stats that about 75 % of people are gone in year one, there’s 25%, especially hemorrhagic, 25 % at the time. 25 % a month later, 25 % at the end of the year, another 20 at the end of year two. I’m like, I’m gonna go through all this and then I still have so little chance. So I just went for it and I went really hardcore. Bill Gasiamis (15:25)Did you eat, drink too much to manage emotional ⁓ stress, challenges? What do you think was behind it? Or was it just bad habits? Or did you think you were bulletproof? What was the reason behind it? Medication Management and Health Improvements Pete Rumple (15:42)Everything you just said, Bill, everything you just said. Yeah. I mean, it’s everything, right? You start justifying bad behavior. You have a reason for why things happen. And I just like, even when I try to lose weight, though, I might lose a couple pounds, but then I eat again and what I was eating, how I was eating. So in that first year, I went super deep on nutrition. and how your body works. And I went from, at the stroke I was 337 pounds. And then when I did my podcast with you, I was 180. Bill Gasiamis (16:25)Yeah, well, ⁓ one of the books that I’ll mention to people, you might have read different ones, and that’s cool. But the one that always comes to mind that I always recommend is Grain Brain by Dr. David Pelmutter. So if you’re in the very early stages of recovery and you want to make some changes like Pete did, read or listen to the book Grain Brain by Dr. David Pelmutter, and then ⁓ read a book called ⁓ Why We Get Sick. ⁓ I’m going to quickly do a search on ⁓ online because I keep forgetting the person’s name. ⁓ And what it’s going to do is going to why we get sick by Benjamin Bickman. And what it’s going to do is going to give people an insight into the. ⁓ I one of the things is the first book is the food that you can avoid and stop eating and the reasons why and how they benefit the brain and then ⁓ why we get sick is an insight into, in fact, exactly that why we get sick. so that you have an understanding of what might have got you into that real bad state. And then also before that, ⁓ the food component of it, because those two things, if you know why you got somewhere and then you know what the trigger was, what the thing was that made you get there, so the food, for example, then you’ve got a great foundation for taking the next step forward ⁓ and reversing it. Pete Rumple (18:02)Absolutely. Bill Gasiamis (18:04)and improving your health and improving your diet, losing weight and decreasing your risks of heart attack, stroke, cancer, all that kind of stuff. ⁓ So I love that you got curious. That’s what I did. I was in hospital reading and watching YouTube videos about how I’m going to recover, how I’m going to overcome things, all sorts of stuff like that. And it was… Pete Rumple (18:19)I remember. Bill Gasiamis (18:31)in a situation where control is given over to medics, doctors, surgeons, all that kind of stuff, you feel like you’re a little bit of a, you’re just floating in the wind and you’re not really stable and you don’t have an anchor point, right? So when you, if you want to feel like you’re a little more anchored, what you could do is you could take control of the controllables and Nutrition is one of those controllables and it doesn’t cost you any extra. You don’t have to spend money. Pete Rumple (19:04)You’re absolutely right, Bill. It’s a huge point. By the way, there’s a great app, and I know there are many, but there’s a great app called Yuka, Y-U-K-A. You can scan any barcode in the store and it will tell you the score and what’s wrong with it and the amount of food I was eating that was, especially in the U.S., Bill, heavily processed, additives, dyes. It’s like toxic. And so you can scan it and know what’s really in it. And it tells you what’s good, what’s bad. And it was a huge help. Bill Gasiamis (19:44)Yeah. So we’re going to have some of these links in the show notes for anyone who wants to find them. I’ll put a link to the books. I’ll put a link to Pete’s previous episode. We’ll put a link to that Yuka app. Pete, that’s your homework. You have to send me that link when we’re chatting. ⁓ When you say you’ve lost 150 pounds, like that is 50 kilograms. That is almost two-thirds of my weight. Well, it’s actually, yeah, it’s about two-thirds of my weight. That means that if I lost 50 pounds, I would just be a bag of bones. Pete Rumple (20:30)Well, and Bill, I was a bigger guy to begin with. have a big frame and I played a lot of US football, American football. So I had a lot of weight to lose, Bill, and it’s gone now. And I’m back up to about 205 and it’s all muscle life, about a 32 inch waist now. really, really fit and I go for it. And by the way, by the way, I want to make one point to all listeners that took a long time, Bill, like between being the wheelchair for eight months and then getting the pool. It took a long time. I used to go and sit and watch people work out to just reacquaint myself. Bill Gasiamis (21:03)How old are you? The Role of Visualisation in Recovery Pete Rumple (21:29)what it looked like and inspire myself. It has been a long road, but my goodness, is absolutely I’m on the other side of it now. Cause as I had said in the first podcast, the first 18 months, I did not want to live, especially year one, ⁓ immense amount of pain. had been a successful executive that was gone. Like it was really really rough. And so now it’s beautiful. And I want people to know that because it it’s so worth it. Delay gratification, you learn a lot about it. And it’s ⁓ Yeah. Bill Gasiamis (22:14)I love that delayed gratification, but also you went into a gym watching other people train when you couldn’t train, just so you can be around it and familiarize yourself with it again. That’s really interesting. That’s probably one thing I’ve never done is go to a gymnasium and watch other people train. It’s a bit creepy Pete. Pete Rumple (22:32)Yeah, it is. It’s weird. And people would look at me like, what’s he doing? And by and by the way, Bill, I did a lot of work on how to breathe, which was really helpful, how to how to manifest and to really sit and get mentally so I go even today, Bill, I go in a half hour before my workout to work on breathing and visualizing my exercises, because I get the the list of what my workout is before I get there the night before. So I study and I prepare and then go. Bill Gasiamis (23:10)What I love about visualizing is that if you visualize the brain actually fires off the exact same neuron and pathways that it does if you actually physically do that thing. And there’s been studies in the past that have showed that you can take an average guy like me and you can make them watch a video of somebody doing archery, for example, and you can ⁓ take them through a number of repetitions of this person, this champion doing archery. And just with that information and the visualization techniques later, you can take somebody who has basically never shot ⁓ an arrow through a bow and you can get them to a certain level of competence far more rapidly than you would have if you just got that person out of a crowd and sent to him. Have you ever shot an arrow? If they said no and they took the shot, they probably wouldn’t be able to do it as well as the person who was trained by just watching what the other person, the champion was doing. And when I was in hospital wanting to walk again, I’m sitting in my bed between sessions because I had a wheelchair as well. And I was visualizing myself doing the perfect walk, what the perfect walk would look like. And then I would take myself later to ⁓ therapy where I would be walking and I would be trying to replicate what I was seeing in my head so that we could get a similar result. And of course at the beginning, your leg is now doing it physically and it needs to catch up to the brain. The brain has ⁓ the pathway, but the leg needs to catch up. So then what the leg does is it goes, this feels a bit weird or this is a bit strange or this is not how I expected it. But it has a reference point for where to get to and how to do the perfect step, right? And then you’re closer to the perfect step than you were if you were just relying on therapists to ⁓ train you through that. Pete Rumple (25:22)You’re absolutely right, Bill. And the brain is amazing. Look, it can work for you or against you depending on what you’re thinking and how you’re doing things. And it was really amazing, Bill, because as I built my capability through CrossFit, it was amazing how my brain would start to take over. Like I wasn’t sure, but my brain was already, I got it, and so grew. It started carrying me and just getting it done. It’s amazing. Bill Gasiamis (25:58)Yeah, yeah. Embracing Discomfort for Growth But how did you know to do that? That’s the thing that I’m interested in understanding because I didn’t know the guy before stroke didn’t know about doing like magic like this. know, how do you, I don’t know, like, can you explain how you found yourself in that situation? Cause I can’t, people go to me like, well, how did you know to do that? Or how did you do that? And I’m like, I don’t know what happened, but something clicked. that made me stumble onto, discover, find all the necessary tools that I needed to get me to the next stage. I’ve never been able to do that before and I can do that now. Pete Rumple (26:46)Yep, me too, Bill, me too. And you know what? I think it’s how desperate we are for answers. And especially you can read all these blogs about what doesn’t work and what’s a waste of time, but you find the nuggets and you go for it. Here’s a great one, Bill. And I’ll send this in the link. Andrew Huberman, he runs a podcast called Huberman Lab. He had David Goggins on and he purposely waited for Goggins to share with him the research around the AMCC, which is the anterior mid-cruciate cortex, which is a part of the brain. And when you do things that are hard and you don’t enjoy it, that part of your brain grows and gets stronger. So I sat there, Bill, and I’m like, well, damn, if I can start to make my brain stronger, I’m going to do it. So I did all the stuff I hate to do. And I started doing it. And I started even faster, talking better, walking better, and really doing everything I did not like to do. And he even brings up the point when he describes it. He brings up that if you like running every day, It doesn’t work. But if you hate running and you have to go run, it works and it makes sure and make, they’ve learned so much that was, that was about three to four years ago. They found it, but this is a massive find in the brain. And I started using it, Bill. And what I started to do was everything I did not enjoy or created pain. I’m like, I’m doing it. And it took me from averting it to leaning into it. And it was amazing. it’s, you’d think it’s BS, it’s not. And Huberman, you know, he works at Stanford. He knows his stuff. It was really, really impactful. Bill Gasiamis (29:03)Yeah, it’s about being comfortable being uncomfortable, isn’t it? Like it’s realizing that you’re probably not killing yourself by paying in a little bit of pain exercising. also, yeah. Pete Rumple (29:16)And Bill, I will just say, I did a very good job for the first time in my life of listening to my body. So I go hard, I push, but when I wasn’t feeling it or didn’t feel right, I take the day, relax, and then come back stronger next. Bill Gasiamis (29:38)I want to pause there for a second because what Pete just described is exactly the kind of thing I wrote about in my book. The idea that the obstacle is the path, the doing the hard stuff in recovery. If you haven’t grabbed the copy yet, it’s called the unexpected way that a stroke became the best thing that happened. You can find it at recoveryafterstroke.com/book. The link is in the show notes and in the YouTube description. So let’s get packed. to Pete. Bill Gasiamis (30:08)Yeah, yeah, agreed. And it’s important to listen to your body after a stroke, because you don’t want to make things worse, especially when you’re still healing and still recovering and you’re still fragile, you know, there’s a lot of things that you need to take into consideration. However, being uncomfortable and being comfortable with that is really a good skill to master. ⁓ It is, ⁓ it reminds me of the saying that we hear that’s often attributed to the old great Roman Emperor Marcus Aurelius, which is the obstacle is the way, you know, when you get to something that’s really hard, you go for it, because that’s what you’re to be. That’s the purpose of the obstacle. It’s to overcome it, to find the way around it, under it, over it, through it, whatever it is. And Goggins is a scary guy. He’s a scary guy, because he runs without, without cartilage in his knees or something. I don’t know what he’s missing. but he shouldn’t be able to run, he shouldn’t be running and somehow he still runs. I think his version of running is a little toxic. I think he’s just a slight too far, ⁓ but nonetheless, it’s still proof of ⁓ what you’re capable of and how much people can push and go beyond their comfort zone. And if you’ve never pushed beyond your comfort zone, there’s no better time to do it. You really have to do it now because you want to activate the right neuroplasticity. You don’t want to activate negative neuroplasticity, which rewires your brain to be more comfortable, less willing to do hard things. ⁓ And therefore, you get the results of that. You get the decrease in your recovery or the ⁓ overcoming of your deficits. So I appreciate that whole ⁓ mentality of finding what’s hard and you’re probably in the right place. That’s probably what you need to do. Pete Rumple (32:07)Absolutely right, Bill. And I agree with everything you said. And look, I love Goggins, but it’s not to be like a warrior like him. The point is, like with Huberman, it was cool because Goggins thinks that way so much. He wanted to launch the foundational research with Goggins there with him. He purposely waited. So it was pretty cool. Bill Gasiamis (32:35)Yeah. And that that’s the thing, right? It’s like you get rewarded for doing hard things. ⁓ Stroke is hard. And if you ⁓ take the easy route, the comfortable route, the hard part of your stroke remains hard. Like it doesn’t get better. If you choose the other hard, the recovery Pete Rumple (32:59)right. Bill Gasiamis (33:04)benefits that you get from choosing hard of exercise, the hard of changing your diet, the hard of changing your mindset, et cetera. Like then that version of hard gets you a reward that is beneficial. The other hard just gets you more suffering. And that’s the hard you wanna avoid. Suffering without purpose. Well, suffering for a purpose gets you a payoff. The Power of Hard Work and Persistence Pete Rumple (33:31)That’s right. That’s exactly right, Bill. And look, with the, when you put it all together between the diet, though, increasingly working out, going after the deficits, all that, day by day, painful, hard, depressing, but you start looking three months, six months, a year later, you’re like, you start building your will and your ability. to do things you did not think you could do, and then it starts feeding on itself, and it becomes so powerful. Bill Gasiamis (34:09)Yeah, that’s my experience too. ⁓ Somebody put it in my head that I should start a podcast 10 years ago. It’s been 14 years since my first stroke this month, February, 14 years. It’s just gone like that. And then about three years in, a friend of mine said, should start a podcast type of thing. So I did. And it has been more than 10 years that I’ve been doing this podcast. ⁓ And I never thought that I’d be doing a podcast, let alone for 10 years. We’re talking about at the beginning, not a lot of episodes because I was too unwell to put a lot of episodes out. it’s ramped up now in the last four or five years, doing an episode a week, most weeks. And then the other thing I never ended up, I never thought I’d end up doing is writing a book here. Here’s the plug for the book. Pete Rumple (35:01)love it. I love it. Bill Gasiamis (35:03)The title is mental, like it’s the unexpected way that a stroke became the best thing that happened. ⁓ But the book is exactly the things that you’ve said. And I thought initially when I discovered those things about my book that I needed to put in my book, I thought that I was rediscovering these for the first time. Like at the very beginning, diets, ⁓ mindset, ⁓ exercise, sleep. ⁓ ⁓ meditation, hanging around other people who are positive, all that kind of stuff, doing stuff for other people, ⁓ like volunteering, that kind of thing. I thought I was discovering these things ⁓ for the first time ever, but turns out these are things that humans have always done. That’s what they default to. They default to all of these things when it’s necessary, and that’s where they get lost from. They kind of move away from there because they get diverted from there, from say, marketing or advertising or what somebody else is doing or through a lack of ⁓ focus from being distracted from work, from relationship issues, whatever the situation is. I didn’t write anything different in my book than has been written in the hundreds and thousands of books on this topic that have come before it. I just reorganized that and set it in my own words. But the reality is, is this is what people do when they’re trying to recover. They default back to the bare basics and they’re things that you can implement without ⁓ spending any extra money buying a course or anything like that. Of course, you might need to read it in a book for the first time to remind you or you might need to hear it on a YouTube video, but the reality is, is that nothing new in this book. Pete Rumple (36:51)And Bill, I want to take a second and plug your book because I have not read it yet. But back in the first ⁓ the first session I did with you, I referenced a number of things you taught me through the podcast that I did to make to start building momentum like the cooking dinner every day was the to do. That was your mission. Yeah. so much of what I’ve learned from you, the podcast and what’s inevitably in the book was a great starting point for me. And I built my, my stuff on top of it, but it was really great to stand on your shoulders and get, and get that lift. Bill Gasiamis (37:38)Yeah, isn’t it weird? Like it was just one thing, but it was the most important one thing. My whole world revolved around that. If I could put dinner on the table for the family in any capacity, it didn’t have to be like a five star meal or three courses or anything like that. It just had to be dinner. If I could do that, then that was kind of how I rehabilitated myself. I needed to be healthy enough, good enough, fit enough, have enough energy to just put a meal on the table for everyone when they came home from. work. was such a it’s such a it was it was important for many reasons. But it was also what I didn’t realize the underlying benefits that it was creating, which were the ones that ⁓ I noticed later after Pete Rumple (38:25)Yep. And you were re-engaging and you were pushing yourself. And I remember you go to the store to buy the stuff you needed sometimes. like all that stuff, Bill, when I look at the beginning, I couldn’t watch a TV for over a year. I couldn’t listen and did not listen to music for two years. It was, and now I’m like back in the fold, but it’s the push, the push, the push and just, you know, listening to the body, but going for it all the time. Bill Gasiamis (39:03)Yeah, exposure, like exposure, exposure, exposure, small, then larger, then more and more. I remember going to the stores to the local mall here, and we call it a shopping center, and parking the car, and then not being able to remember where I parked the car, walking around the entire car park, and talking to my brother, and going to him, he rang me just out of blue and I said to him, he goes, what are you doing? I said, I’m walking around the car park. He what are you doing that for? That’s because I don’t know where my car is. I’ve been looking for it for half an hour and I’ve got no idea where it is. I parked it and I just got no idea where. I don’t know which car park. I don’t know where I came in from. I don’t know what level it was on. And I was just walking around the car park talking to my brother, just telling him, I came and got a few things, but now I can’t get back to my car. Pete Rumple (39:55)Yeah, and there’s definitely you know bill once I got out of the darkness There’s definitely some really funny stories That that happened especially like the way The way I would walk people would see me I might be in a restaurant and i’m going to the bathroom and they think i’m drunk Yeah, and they’re like making fun of him like hey i’m not drunk, but ⁓ I get you know, I’m all right, I got it. And they’d be like horrified and I’d just start laughing. It was funny, but you gotta have some fun with it too, you know? Bill Gasiamis (40:34)Absolutely, you have to, you gotta laugh. you don’t laugh, well, it’s gonna be difficult time. You, ⁓ I remember when we spoke last time, you mentioned about trying to get back to work. ⁓ How did that go? Was it successful? Did you have some challenges? What was going back to work like? The Journey Back to Work Life 3 Years After Stroke Pete Rumple (40:53)So Bill, I’m gonna start back in June. I’ve done some projects, work projects, but I have not officially started working, but I’m going to. I’m starting a business with a close friend of mine, my former CFO, and we’re gonna start a new business. Bill Gasiamis (41:18)Tell me about the new business. What is it about? Can you share anything about it? Pete Rumple (41:22)Yeah, it’s called fractional leadership bill will probably go to companies that are ⁓ getting funded, trying to grow. They got a good idea. They can’t afford the people they need. So you basically it’s less consulting. It’s more you’re operating it for them and you work with multiple customers and it’s called fractional leadership is becoming a really pretty popular model. And, ⁓ and also for companies that have that have their revenue is stalled or shrinking, get them turned around. That was my background. My background was ⁓ running chief revenue officer. So everything that drives revenue in a company and I was a CEO twice. Bill Gasiamis (42:06)Uh-huh. Soon. Did you have a specific industry that you worked in? Pete Rumple (42:23)Yet a lot of times I call it TMT for telecom media and tech so tech companies and media and That kind of stuff Rosetta Stone was his language learning company. I was I ran all our institutional business education government and and ⁓ Corporate Bill Gasiamis (42:49)Wow, what a challenge. mean, technology is changing so rapidly. ⁓ I Pete Rumple (42:55)love it, Bill. And look, I’m sorry, I just had to make this point and not forget it. That was another thing I’ve done, Bill is I’ve gone heavy into AI. And I did it, not just because it’s the buzzword. But I’m like, Hey, if I’m going through this process, if I’m retraining my brain, why not try to get good at stuff that I either didn’t do or need to know. And it’s been so rewarding, Bill. Bill Gasiamis (43:24)out. Pete Rumple (43:25)It’s just crazy. Like AI, use chat chat, GBT, and it’s like my, my best friend. now work with chat daily and it’s amazing how the tech technology works. Not only can it be really helpful for figuring things out and having a partner, but it also remembers things about you in how it builds the profile. So it’ll basically say, Pete, don’t forget this, this, and this. And it’s awesome. It’s really killer. Bill Gasiamis (44:02)So here comes another plug, Pete. Okay, so this is not a sponsor, but it’s something that I truly believe in, okay? Because the person who contacted me, A, is an Australian, B, is a mother, ⁓ C, is a mother of two children with cerebral palsy. And she was looking for solutions to all the challenges that they faced as a family, especially to help her children, right? parent would do. So then ⁓ she used to do research like you and me jump on the computer, do some research, find out about all the things that ⁓ she needed to know with regards to what was most current in cerebral palsy right now. And she’s the struggle because ⁓ imagine like the time that it takes when you have a stroke brain to research, read, comprehend, determine whether Pete Rumple (45:01)We know. Yeah. Yeah. Yeah. Bill Gasiamis (45:04)whether or not that is applicable. Okay, that’s not applicable. Put that to the side, do another search. And then also going to doctors and researchers and all these other people and saying to them, what about this? What about that? And then them not being aware of anything that was new because they’re too swamped. They’ve got a massive workload. They don’t have time to be up to date with all the research, right? And this is a hundred percent a full on plug. I’m not apologizing for that. However, what this lady did, Jess from turn2.ai, I have a link to her interview as well, because I interviewed her, is she created an ⁓ AI that goes and does the research, the searching for you, and then sends you an email every week with everything new in your particular topic, for example, stroke. And then it tells you, I found seven, nine, 10 things for you this week that are new on stroke. It could be a podcast. It could be a research document. could be ⁓ whatever it is. It could be a book. It could be anything. It just finds it and sends you that information. And as your recovery continues, right, ⁓ what happens is ⁓ you might say, okay, now is there any information about food related to stroke recovery and healing the brain? And then it adds that to the search list. And then it comes back at the end of the next week with all the new information from food and brain. And then also whatever it was that you previously prompted it to find you. And it just keeps finding information and you build it and you build it and you build it. And then next week you get interested in meditation and you type, what can you tell me about meditation and healing the brain? And then it’s going to bring you all that information to your inbox. I spent hours and hours and days and days trying to find information about what I needed to know about stroke recovery. And when I found that little piece of paper, I had to go through the rabbit hole. I had to go down the rabbit hole and try and find ⁓ where ⁓ where it kind of where the exit point was where it led to so that I can discover whether I need to implement this, do this. So this just saves so much time and the guys are selling it for two bucks a week. Like you can get a month free and two, and then after that it’s two bucks a week just to find and do all the searching for you and bring you specific and relevant stuff. And we’re talking about scientifically relevant and specific like PubMed articles, like scientifically proven stuff, not what Bill ⁓ concocted up in his bedroom. you know, in suburban Melbourne, like proper things. So I love that you said that you’ve turned to AI. I’ve been using chat as well. Chat helps me with so many things, but what’s important is to learn how to interact with it. And that’s another, that’s another thing, another skill to discover. And it’s important that we jump on the bandwagon. AI is not going away. You need to learn about it, how to interact with it, and how to use it to benefit you and decrease the amount of time it takes to do something and get to recovery. Pete Rumple (48:37)You’re absolutely, absolutely right, Bill. I mean, it is, and even if you just use it for basic stuff to begin with, and you start learning how to create the right prompts to get the kind of answers you’re looking for, it’s a great skill. And the biggest thing is not being afraid and leaning into it. Bill Gasiamis (49:00)Yeah, not bad. Well, there’s nothing to be afraid of. They can get them all for free. At the beginning, you can get a free subscription. It doesn’t cost anything. And it’s just as useful. Perfect for that early training kind of phase in your chat, in your chat, JBT kind of discovery. There’s also Claude, there’s also the Elon Musk one. There’s hundreds of them now. Yeah, there’s heaps of them now, right? So I really encourage people to do that because If you ask it one question like, you know, what is one of the most ⁓ best books that I can read for, we’ll call it nutrition for nutrition and stroke recovery. That’s just going to decrease the amount of time it takes to find those books and bring that to you. Jump on Amazon, find it, get it sent to your house. ⁓ So I think it’s a great time for people. and it’s never been a better time to recover from a stroke. I mean, it’s a shit ⁓ group to become a part of at the beginning and it’s difficult and it’s painful. But if somebody has a stroke today compared to a stroke 30 years ago. Pete Rumple (50:17)⁓ my goodness. Bill Gasiamis (50:19)Like it’s a completely different experience. ⁓ I think we’re kind of lucky to be living in the time that we’re living. ⁓ Even though I know that people hear about AI and what it could potentially do in some other situations. ⁓ Let’s use it for good. Like let’s break the work. Pete Rumple (50:21)That’s all we’ll That’s right. That’s exactly right, Bill. It can be used for evil, but it can be used for good. So use it. That’s right. Navigating Health Challenges Bill Gasiamis (50:48)Yeah, just like any technology, right? Like you hear all these things, but any technology can be used for good or evil. So let’s just use it for good. Let’s just make the most of it. So before your stroke, you were going through a divorce or had you already been divorced? Pete Rumple (51:08)I was already divorced. Yeah, it had been it had been a couple of years earlier. I had a bad car accident a bunch of but you know the kids live with me. It was just a stress sandwich and I did not go out the right way. Bill Gasiamis (51:27)Yeah. You didn’t go out at the right way because what do you think was behind that? Like, it’s hard to make really good decisions in very stressful times anyway. You have to have an opportunity or the insight to pause, step out of that situation for a little bit, reflect and then try and make decisions. how did you get into that stage where you found yourself not being ⁓ not going about things appropriately, for example, perhaps. Pete Rumple (52:02)For me, Bill, it was like I didn’t have a choice. I was now in a wheelchair. I was in pain and I had nothing I could do but think. And at first that was very negative. It was, I didn’t handle it well. I didn’t accept it. And once I went through that process and I got like, okay, I’m going to get holistic about this. And by the way, I don’t want to, I don’t want to just fix the physical and then I get done and everything else is a wreck. So went after all of it and just started carving up my day, spiritual, cognitive, physical, mental, every day, a block of each practicing writing, all that stuff. So I just started doing it and rebuilt my life. probably like I should have in the first place, but stuff happens. I had to, you sometimes, you know, we, you and I laughed about this before. Sometimes we’re a little thick. takes a little longer. So it took me a while, but I’m there now. Bill Gasiamis (53:18)Yeah. And reflecting on that version of yourself from the past, does that does that person ever come up again, every so often, because we’re talking about all these positive things, all these amazing changes. And I don’t want to paint a picture that it’s only ever fantastic you and I like what we go through after our initial stroke has been all just roses. Is there moments of that things rearing their ugly head and you reverting back, how do you catch yourself when you’re there? Pete Rumple (53:57)Yeah, I mean bill that’s why what’s really good about this is my first podcast with you because we went really deep in the in the darkness of that now bill is beautiful man. It is beautiful. I am almost I almost don’t talk to people about it because My life is so much better because I had a stroke. It’s crazy. It sounds nuts, but it’s so true. Everything’s sweeter. I just, it’s hard to describe. It’s a blessing. Bill Gasiamis (54:38)Yeah, that’s crazy. It is probably crazy. Pete Rumple (54:42)It is? Bill Gasiamis (54:45)I find myself, ⁓ I find myself obviously having bad days. My bad days are related to stress, ⁓ you know, work, if they’re related to ⁓ interactions with people that don’t go the way that I preferred. They’re related to ⁓ what the stroke still does to me after 14 years. ⁓ It still causes neurological imbalances. still causes tightness on my left side, know, that tightness causes dysfunction on my right side, you know, the body goes out of whack. And if I catch it, if I have a bad night’s sleep, things get thrown out and it’s hard to, ⁓ it’s hard to always navigate it and be effective at catching it and then doing something about it, you know, cause you’re human, you get distracted, et cetera. Pete Rumple (55:38)Well, and Bill, you’re bringing up great points because as I transition back to work, I’ll have some potential potholes that I don’t have right now. So I’m very, I’m very conscious of what I’m going to go back into. Now. I love, I love work. It’s my sport and I love it. But, ⁓ and today I have now. bad moments, not bad days. Maybe those occurred, but I’m going to try to stave that off. But that’s just how it is now. as of as of now, that’s that’s the update, if you will. Yeah. Resilience and Consistency in Recovery Bill Gasiamis (56:25)Yeah. Okay. I like that you said that about work, like there’s gonna be some potholes with if you’re doing the type of work that you’re doing. ⁓ That’s pretty high level and high stress and intense for ⁓ at some stages, it could be right, you’re talking at organizations that are going through a hard time that are looking to you to solve their problems, so to speak, or to support them solve their own problems. So ⁓ You know, the ramping that up is gonna need a little bit of thought so that you don’t go too far into that type of work without realizing how far in you’ve gotten. Pete Rumple (57:10)Absolutely right, Bill. You’re absolutely right. And look, I’m going to try to be as bulletproof as I can. The good news is I’ve been doing this work my whole career. So it’s been 40 years. So I don’t think I have to micromanage or get to like, I think I can find the right balance if I can’t. I’ll go to a lesser job and do something else. But so I realize, especially because I can get pretty intense. So ⁓ I realized that is a risk, a very real risk. I’m not shying away from it. I’m not saying, don’t worry. yes, there is stuff to worry about, but I’m gonna, I’m gonna test and learn. Test and learn is what I always do. Test it and learn, can I do it, not do it, do I have to do different, do I have to do something else? Bill Gasiamis (58:14)Yeah, brilliant. How old are you now? Pete Rumple (58:17)61. Bill Gasiamis (58:18)Okay, so at 61, most people are thinking about retiring. What are you thinking starting a new business at 61? Pete Rumple (58:25)Well, mean, Bill, look, let’s be honest, I think the last three years off. So I have some ⁓ room left in the battery. But I mean, part of the reason for this type of job, Bill, is because if we do this, we run it. And we’ll decide how we take care of clients, how we work and all that. And if I have to take on less, take on less. If I can take on more, take on more. And I’m gonna, like everything else, I’m gonna figure it out one step at a time, Bill. And I, you know, I don’t have the answers, but I’m gonna find them. Bill Gasiamis (59:11)And retirement’s not really in the frame for you. Like it’s not something that you’re thinking about, like to ⁓ officially retire, know, step away from the day to day and just, you know, go and sail off into the sunset type of thing. Pete Rumple (59:24)Yeah, I think to your point, Bill, like if I can make this work, I’ll probably work through my 60s. If I can’t, then I’ll have to probably hang it up earlier or do something lighter. And if that’s the way to be healthy, so be it. I’ll do that. Bill Gasiamis (59:43)What else does work bring you though? Because it doesn’t just bring work income. Like it brings more than that. Like for you, I feel like it’s more than just I’m making a wage or bringing in some money or whatever. What else does it bring? Pete Rumple (1:00:02)Yeah, it’s it’s competitive, Bill. It’s it’s my sport. You know, so hitting the numbers in a month and a quarter and a year. That is the scoreboard for what I do. And if you if you do it well, you can do really well and be very happy and influence a lot of people’s lives in a positive way. And if you don’t, it can be really awful. So Fortunately, I’ve been on the right side of that for a long time and I want to get back to it and no ego stuff I just I want to I want to I want to have an impact and I want to enjoy my sport. Bill Gasiamis (1:00:48)Fair enough. Even in your unhealthiest and heaviest before the stroke, were you this energetic? Did you have this same amount of energy? Pete Rumple (1:01:00)I’ve always been energetic, Bill, but I couldn’t operate like I do now. Like my sleep is wonderful. I go hard at the gym. I do projects. I volunteer. Like I’ve been readying myself for coming back in. And look, if I can, great. If I can’t, I’ll adapt. Bill Gasiamis (1:01:27)Yeah. I know when I went back to work, uh, well, I had to, I had to pause my business. have a painting and maintenance. Yeah. I had to pause it. I had to go back into an office, very basic admin role, like low level, but it was so hard being at work, sitting in front of a computer for eight hours a day. We started, I started that job in 2016 and finished in 2019. By the time I got to 2019. Pete Rumple (1:01:36)I remember. Bill Gasiamis (1:01:57)I was way more capable of going in focusing on the task at hand and doing the work that needed to be done and then being able to be okay to do the drive home because at some point at the beginning I wasn’t really able or up to the task. But I kind of built ⁓ the muscle again and then got to that stage where by 2019 it was fine. So some people might find going back to work like You know, retraining that muscle of being at work and working and focusing and all that kind of stuff. They might find that it’s gonna take a little bit of time to get there and you might have to step back. You might have to decrease the days, decrease the hours and then go again and then try and find where the threshold is, see if you can exceed it and then see how far you can push it and reflect a year, 18 months, two years. Pete Rumple (1:02:38)That’s right. Bill Gasiamis (1:02:56)down the track back to notice how far you’ve come. Pete Rumple (1:03:00)Yeah, right on Bill. I mean, I’m gonna have been out of it for 42 months, probably when I go back. So I hear you loud and clear, and it would have been really tough to do it. before now. Bill Gasiamis (1:03:20)Yeah. Yeah. And you did have a you had a goal to get back to work a lot earlier. Pete Rumple (1:03:29)Yes, that’s right. And ⁓ that’s another thing, Bill, like I’ll set an intention to do something. I’ll go for it. I’m not ready. I’m not gonna, I’m not gonna do it wrong. I’m not gonna hurt myself. So I set a goal. I try to manifest it, but if I have to push it, I push it. Bill Gasiamis (1:03:51)Yeah. Just before we spoke and started this episode, you’re you apologize for wearing a hat, which is was unnecessary ⁓ because you have a scar on your head because there was a skin cancer found. And before it became a thing, the you got you had it removed. That’s right. So now when So I wanna understand like your mindset now compared to before when you come across ⁓ an issue like that, a health, potentially health issue for people. How do you navigate that now compared to how you might have done things before? ⁓ Proactive Health Management Pete Rumple (1:04:38)Beautiful question. Yeah, I used to avoid all that stuff. I avoided the doctor. I don’t want to do this. I want to there’s always a reason to do something else. Now I lean in, I pay attention, I learn I go in, I may agree or not agree with the doctor on certain things. But especially now because I can think again, took me a couple years. But yeah, I lean in. I want to I want to get in there. I want to know what’s wrong. What’s right. What have you just had my annual exam two days ago ago. It went great. Labs came back great. I I my neurologist that I used to have to ⁓ visit quarterly said Pete I don’t even need to see you annually now. Just if you need me call me. Other than that you’re good to go. And she said, we have not seen this kind of recovery before from what you had. Bill Gasiamis (1:05:43)Yeah, I have a similar experience when I was in hospital. They booked me in for two months. I was out in a month ⁓ in rehab and I feel like they should have asked me what I was doing because It’s really important for people to know the difference between being passive and waiting for somebody to rehabilitate you or being the person who’s driving your own rehabilitation. Like there’s a massive difference and Pete Rumple (1:06:13)Huge difference, Bill. You’re right. Huge difference. mean, last last call, I talked to you from my sister’s house in December, just a couple months, few months after it, I made the decision to move out on my own, which I did, which really stunk, Bill. That was hard. Like, I there were some nights I couldn’t eat. I was like, I can’t I’m either gonna make the the bed or the kitchen, which am I doing? Bed. And I just do it. And but it was important. It was important to start knowing where I could push and not being too reliant. Bill Gasiamis (1:06:59)Yeah, yeah, the less reliant you can be the better, but still also good to be able to rely on people when you need a little bit of support. Pete Rumple (1:07:05)Right on. Absolutely. don’t, you know, it was, there’s not a right or wrong. It’s like, what do you think? What’s your gut? Bill Gasiamis (1:07:14)Yeah. Now let’s do a little bit of a community service announcement about this skin cancer. A, how did you notice it? ⁓ What were the steps that you took after you noticed it? How long did you take? Why did they remove it? And so on. Give us a little bit of information. There’ll be people listening here who ⁓ may have noticed a little bump or a lesion or something on their face, their head, their arm, whatever. Give us a little bit of an understanding of how that came to be. Pete Rumple (1:07:43)absolutely the one thing I’ve done Bill through my life as I’ve stayed disciplined on the dermatologist and I don’t know why I think it’s how I was raised everything else I skipped but the dermatologist I stayed on top of and to your point if I notice something and it seems pervasive like it’s not going away I have it looked at a
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In this new episode, Crawlspace Media's Tim Pilleri & Lance Reenstierna are joined once again by friend of the show and expert in all things media + crime related, Dr. David Perlmutter. As the clock continues to tick on the abduction of Nancy Guthrie, Dr. Perlmutter helps to break down how the media releases information, what is important for the public to know and what's important for the public to not know. If you have any information please submit a tip to the FBI at 1-800-225-5324. You could also submit a tip here: https://tips.fbi.gov/home. More info: https://www.fbi.gov/wanted/kidnap/nancy-guthrie. Savannah's Instagram video: https://www.instagram.com/p/DUW3mpqD8qd. Check out Quince: https://quince.com/MISSING. Main podcast theme by Kevin Macleod. Check out his work at https://incompetech.com/. Additional music by David Williams. See his work at http://williamsflutes.com. Follow Missing: IG: https://www.instagram.com/MissingCSM/. TT: https://www.tiktok.com/@missingcsm. FB: https://www.facebook.com/MissingCSM. X: https://twitter.com/MissingCSM. Spotify: https://open.spotify.com/show/0yRXkJrZC85otfT7oXMcri. Youtube: https://www.youtube.com/missingcsm. Apple: https://podcasts.apple.com/us/podcast/missing/id1006974447. Follow Crawlspace: IG: https://www.instagram.com/Crawlspacepodcast. TT: https://www.tiktok.com/@crawlspacepodcast. FB: https://www.facebook.com/Crawlspacepodcast. X: https://twitter.com/crawlspacepod. Spotify: https://open.spotify.com/show/7iSnqnCf27NODdz0pJ1GvJ. Youtube: https://www.youtube.com/crawlspace. Apple: https://podcasts.apple.com/us/podcast/crawlspace-true-crime-mysteries/id1187326340. Check out our entire network at http://crawlspace-media.com/. Learn more about your ad choices. Visit megaphone.fm/adchoices
Welcome back to Crawlspace. In this new episode, Tim Pilleri & Lance Reenstierna are joined once again by friend of the show and expert in all things media + crime related, Dr. David Perlmutter. As the clock continues to tick on the abduction of Nancy Guthrie, Dr. Perlmutter helps to break down how the media releases information, what is important for the public to know and what's important for the public to not know. Nancy Guthrie was taken from her home in Catalina Foothills, Arizona on February 1st, 2026. Nancy is the mother of well known broadcaster Savannah Guthrie. If you have any information please submit a tip to the FBI at 1-800-225-5324. You could also submit a tip here: https://tips.fbi.gov/home. More info: https://www.fbi.gov/wanted/kidnap/nancy-guthrie. Savannah's Instagram video: https://www.instagram.com/p/DUW3mpqD8qd. Check out Quince: https://quince.com/MISSING. The music for Crawlspace was produced by David Flajnik. Listen to his music here: https://www.pond5.com/artist/bigdsound. Follow Crawlspace: IG: https://www.instagram.com/Crawlspacepodcast. TT: https://www.tiktok.com/@crawlspacepodcast. FB: https://www.facebook.com/Crawlspacepodcast. X: https://twitter.com/crawlspacepod. Spotify: https://open.spotify.com/show/7iSnqnCf27NODdz0pJ1GvJ. Youtube: https://www.youtube.com/crawlspace. Apple: https://podcasts.apple.com/us/podcast/crawlspace-true-crime-mysteries/id1187326340. Follow Missing: IG: https://www.instagram.com/MissingCSM/. TT: https://www.tiktok.com/@missingcsm. FB: https://www.facebook.com/MissingCSM. X: https://twitter.com/MissingCSM. Spotify: https://open.spotify.com/show/0yRXkJrZC85otfT7oXMcri. Youtube: https://www.youtube.com/missingcsm. Apple: https://podcasts.apple.com/us/podcast/missing/id1006974447. Check out our entire network at http://crawlspace-media.com/. Learn more about your ad choices. Visit megaphone.fm/adchoices
Most brain decline, mood instability, and impulsive behavior start with a breakdown in how the brain's immune cells produce and use energy. This episode shows how mitochondrial health inside microglia influences cognition, emotion, and long-term brain resilience, and how everyday inputs quietly push those systems toward damage or repair. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey is joined by Dr. David Perlmutter, a board-certified neurologist and six-time New York Times bestselling author whose work focuses on the intersection of neurology, nutrition, metabolism, and brain health. A Fellow of the American College of Nutrition and member of the Editorial Board of the Journal of Alzheimer's Disease, Dr. Perlmutter brings decades of clinical and research experience to this conversation on how inflammation and mitochondrial function shape the brain across the lifespan. Together, they explore how microglial cells shift their behavior based on metabolic conditions, and how those shifts influence neurodegeneration, emotional regulation, impulse control, and cognitive performance. The discussion covers real-world inputs that shape these systems, including sleep optimization, fasting, ketosis, glucose regulation, gut signaling, environmental toxins, and tools referenced in the episode such as red and infrared light, 40 Hz light and sound, hyperbaric oxygen, lithium, nicotine, supplements, nootropics, GLP-1 agonists, and dietary approaches like carnivore and ketosis. The conversation connects brain biology to lived experience, showing how metabolism influences behavior, decision making, and long-term human performance through a Smarter Not Harder lens. You'll Learn: • How microglia shift between supportive and destructive states and why metabolism drives that change • How mitochondrial function inside immune cells influences inflammation and brain resilience • How inflammation affects the prefrontal cortex, impulse control, and reward-driven behavior • What the episode says about GLP-1 agonists and behavior changes like reduced cravings and gambling • How gut-derived signaling and short-chain fatty acid balance (butyrate vs propionate) relates to brain function • How tools like red and infrared light, hyperbaric oxygen, and 40 Hz light and sound connect to microglia • The lifestyle levers discussed in the episode: sleep optimization, fasting, ketosis, glucose control, and toxin reduction • The compounds mentioned, including lithium, nicotine, urolithin A, CoQ10, rosmarinic acid, and dihydromyricetin Dave Asprey is a four time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Thank you to our sponsors! KILLSwitch | If you're ready for the best sleep of your life, order now at https://www.switchsupplements.com/ and use code DAVE for 20% off. BodyGuardz | Visit https://www.bodyguardz.com/ and use code DAVE for 25% off. Stop cooking with toxic cookware and upgrade to Our Place today. With a 100-day risk-free trial, plus free shipping and returns, you can experience this game-changing cookware with zero risk. Visit: fromourplace.com/DAVE Use code: DAVE for 10% off sitewide Establish a powerful foundation for sustained wellness with Pique. Unlock 20% off: piquelife.com/DAVE Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: microglia brain health, brain immune system mitochondria, neuroinflammation podcast, mitochondrial dysfunction brain, david perlmutter podcast, dr david perlmutterneurologist, grain brain author podcast, alzheimers brain metabolism, parkinsons microglia, autism brain inflammation, gut brain immune signaling, short chain fatty acids brain, butyrate propionate brain, glp-1 brain behavior, glp-1 addiction research, red light therapy brain, infrared light mitochondria brain, 40 hz light sound brain, hyperbaric oxygen brain health, lithium microglia brain Resources: • Learn More About Dr. Perlmutter at: https://drperlmutter.com/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Join My Low-Oxalate 30-Day Challenge: https://daveasprey.com/2026-low-ox-reset/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com Timestamps: 0:00 - Introduction 1:45 - Autism Spectrum 4:38 - Alzheimer's & Beta Amyloid 7:02 - Brain Immune Cells 8:06 - GLP-1 & Parkinson's 10:44 - M1 vs M2 Microglia 13:08 - Pharmaceutical Microdosing 15:51 - Gene Therapy 19:09 - Mold & Toxins 21:58 - Environmental Pollution 26:05 - MPTP Discovery 29:07 - Healing Interventions 31:39 - Light & Sound Therapy 36:35 - Mitochondrial Function 44:57 - Inflammation & Prefrontal Cortex 48:00 - GLP-1 Global Impact 52:11 - Mitochondrial Community 56:05 - Consciousness & The Field 1:00:00 - Psychedelics 1:01:59 - Love & Judgment 1:06:35 - Death & Knowing 1:09:06 - Heart-Brain Connection 1:11:06 - Closing Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Welcome to Crawlspace. In this new episode, Tim Pilleri & Lance Reenstierna are again joined old friend of the show, Dr. David Perlmutter. The topic this week is trying to understand the killings of Brown University students Mukhammad Aziz Umurzokov and Ella Cook & MIT professor Dr. Nuno Loureiro. Check out Dr. Perlmutter's work: https://www.depts.ttu.edu/comc/faculty/faculty/dperlmutter.php Follow Crawlspace: IG: https://www.instagram.com/Crawlspacepodcast. TT: https://www.tiktok.com/@crawlspacepodcast. FB: https://www.facebook.com/Crawlspacepodcast. X: https://twitter.com/crawlspacepod. Spotify: https://open.spotify.com/show/7iSnqnCf27NODdz0pJ1GvJ. Youtube: https://www.youtube.com/crawlspace. Apple: https://podcasts.apple.com/us/podcast/crawlspace-true-crime-mysteries/id1187326340. Follow Missing: IG: https://www.instagram.com/MissingCSM/. TT: https://www.tiktok.com/@missingcsm. FB: https://www.facebook.com/MissingCSM. X: https://twitter.com/MissingCSM. Spotify: https://open.spotify.com/show/0yRXkJrZC85otfT7oXMcri. Youtube: https://www.youtube.com/missingcsm. Apple: https://podcasts.apple.com/us/podcast/missing/id1006974447. Follow Private Investigations For the Missing Please donate if you can: https://investigationsforthemissing.org/. http://piftm.org/donate. https://twitter.com/PIFortheMissing. https://www.facebook.com/PIFortheMissing/. https://www.instagram.com/investigationsforthemissing/. Check out our entire network at http://crawlspace-media.com/. Learn more about your ad choices. Visit megaphone.fm/adchoices
Welcome to Crawlspace. In this new episode, Tim Pilleri & Lance Reenstierna are joined by old friend of the show, Dr. David Perlmutter. The three of them discuss the horrific murders of Rob Reiner and his wife, Michele Singer Reiner at the hands of their son Nick. Dr. Perlmutter is a professor of Media & Communications at Texas Tech University. Check out Dr. Perlmutter's work: https://www.depts.ttu.edu/comc/faculty/faculty/dperlmutter.php Follow Crawlspace: IG: https://www.instagram.com/Crawlspacepodcast. TT: https://www.tiktok.com/@crawlspacepodcast. FB: https://www.facebook.com/Crawlspacepodcast. X: https://twitter.com/crawlspacepod. Spotify: https://open.spotify.com/show/7iSnqnCf27NODdz0pJ1GvJ. Youtube: https://www.youtube.com/crawlspace. Apple: https://podcasts.apple.com/us/podcast/crawlspace-true-crime-mysteries/id1187326340. Follow Missing: IG: https://www.instagram.com/MissingCSM/. TT: https://www.tiktok.com/@missingcsm. FB: https://www.facebook.com/MissingCSM. X: https://twitter.com/MissingCSM. Spotify: https://open.spotify.com/show/0yRXkJrZC85otfT7oXMcri. Youtube: https://www.youtube.com/missingcsm. Apple: https://podcasts.apple.com/us/podcast/missing/id1006974447. Follow Private Investigations For the Missing Please donate if you can: https://investigationsforthemissing.org/. http://piftm.org/donate. https://twitter.com/PIFortheMissing. https://www.facebook.com/PIFortheMissing/. https://www.instagram.com/investigationsforthemissing/. Check out our entire network at http://crawlspace-media.com/. Learn more about your ad choices. Visit megaphone.fm/adchoices
Week four of the Ending Well series lands right at the halfway mark. This episode is a look back over a three-year road (starting in 2022) of how God helped me fight inflammation, feel like myself again, and regain my "glow." This is not a weight-loss talk, not a quick-fix list, and not medical advice. It's a redemption story about healing from the inside out — spiritually, emotionally, and physically. "Beloved, I pray that you may prosper in all things and be in health, just as your soul prospers." — 3 John 1:2 Key Themes Redemption doesn't just cover salvation; it keeps working through sanctification and healing. Inflammation wasn't just a food problem — it was also a soul and nervous system problem. Real health change is slow, layered, and personal. Your timeline will not look like mine. The glow came as a byproduct of feeling better and living freer, not chasing beauty. Important Disclaimers This episode is descriptive, not prescriptive. Not medical advice. Always talk with a qualified professional for your situation. Do not try to do everything at once. This was a year of foundations plus a total three-year process. One percent better beats perfect overnight. The Story: How the Dominoes Fell 1. August 2022: Stepping Back From Fear-Driven "Crunchy" Culture I was drowning in rules, guilt, and constant fear of what might be harming me. The anxiety and striving became more toxic than the ingredients I was avoiding. First domino: I quit trying to do it all perfectly and started living with grace, budget reality, and peace. Lowering my standards for myself lowered my inflammation. "Come to me, all who are weary and burdened, and I will give you rest." — Matthew 11:28 2. October 2022: A Major Boundary With a Toxic Relationship I set a serious boundary with someone whose presence fueled self-hatred. Went no contact for about six months. The inner tape of shame and criticism began to quiet. I learned that giving up self-hatred is profoundly anti-inflammatory. Recommended resource mentioned: When to Walk Away by Gary Thomas (plus podcast interview) "Guard your heart above all else, for it determines the course of your life." — Proverbs 4:23 3. Early 2023: Changing How I Worked Out I stopped high-intensity workouts that were spiking cortisol daily. Switched to lifting heavy and slow, more functional strength training. Worked out less, recovered more. Energy improved, inflammation eased, confidence rose. Current favorite: Nourish Move Love workouts on YouTube. Big takeaway: exercise is a gift, not punishment. 4. February to May 2023: Going Gluten-Free and Cutting Back on Alcohol Grain Brain by Dr. David Perlmutter was a turning point. I tried going gluten-free (cold turkey, not ideal but it worked). Brain fog cleared, bloat dropped, inflammation noticeably reduced. Cutting alcohol alongside gluten made a huge difference. I don't need to understand every mechanism to honor what clearly helps my body. Reminder: everyone has a "thing" — gluten, dairy, sugar, alcohol, stress. Find yours with grace. 5. August 2023: Getting Off SSRIs After 15 Years A massive milestone with a full story in episode 267. For me, SSRIs were not helping inflammation or overall vitality anymore. The drop in facial inflammation from August to December was dramatic. I'm not shaming anyone on SSRIs — I was on them a long time. This was my path. "It is for freedom that Christ has set us free." — Galatians 5:1 What Actually Healed Me This part matters: the glow wasn't mainly from products. Lowering impossible expectations Creating boundaries Learning to like myself Getting out of fight-or-flight Moving my body in a gentler way Removing gluten and minimizing alcohol Walking in obedience even when it felt backwards Healing was spiritual and emotional first, physical second. "Be transformed by the renewing of your mind." — Romans 12:2 Simple "Glow Back" Skin Habits These are the practical, easy wins that helped the outside catch up to the inside. Dermaplaning at home Removes dead skin and peach fuzz. Skin care and makeup apply better. Big difference in glow and smoothness. Learn carefully through YouTube tutorials and use a quality razor. Stopping skin picking Picking was aggravating redness and irritation. I prayed about it and replaced the habit. New habit: brush my hair when the urge hits. Asking God for help in small things counts. Sponsor Spotlight: PreBorn A free ultrasound can double a mother's chance of choosing life. PreBorn offers ultrasounds plus ongoing support for mothers for up to two years. It costs 28 dollars to sponsor one ultrasound. Donate at preborn.com/speakeasy. Takeaways to Sit With If you're overwhelmed, start with one domino. God often heals from the root, not just the symptom. Your body listens to your beliefs. Peace, obedience, and self-kindness are deeply practical health tools. The goal isn't prettier; it's freer, healthier, and more whole. Reflective Questions What is one area where fear or perfectionism is inflaming your life? Who or what might need a boundary so you can heal? What small change feels like the next right step, not the whole staircase? How would your health shift if you treated yourself like someone God deeply loves? Closing Encouragement This glow-back story is really a "come back to life" story. It wasn't a sprint; it was obedience in baby steps. If you're in the thick of it today, don't despise the slow fade. God redeems years, bodies, minds, and hearts — and He's patient in the process. "He restores my soul." — Psalm 23:3