Podcasts about Nir Barzilai

Send us a textIn this fascinating episode, Dr. Debbie Ozment, DDS, sits down with Dr. Nir Barzilai, a leading researcher in aging, to explore the science behind longevity and what truly influences our health as we age.Dr. Barzilai explains why biological age—rather than chronological age—is the key factor in determining health and lifespan. He discusses how aging drives diseases and how targeting aging at a biological level could help prevent many chronic conditions.The episode explores the interconnected hallmarks of aging, including metabolism, inflammation, immunity, epigenetics, and the microbiome. Dr. Barzilai highlights how addressing any of these hallmarks can positively affect others, paving the way for healthier aging.Dr. Barzilai also discusses the role of metformin, not as a miracle cure but as proof that aging can be targeted. He shares insights into its potential benefits beyond glucose control, such as its effects on immunity and inflammation.Beyond medications, he emphasizes the importance of lifestyle choices, such as exercise, diet (including intermittent fasting), sleep, and social connectivity, in slowing down the aging process. He shares his personal habits and the wisdom he has gathered from studying centenarians.Looking ahead, Dr. Barzilai is focused on advancing research to measure biological age through biomarkers and protein analysis. He also explores emerging discoveries, such as the impact of stress as a new hallmark of aging and the influential role of social connections in extending lifespan.Tune in to discover the latest scientific breakthroughs in aging and practical strategies to enhance your healthspan!Visit my website DrDebbieOzment.com for valuable free downloads. Additionally, you will find shopping links which I have curated on the website. Please follow me on instagram at drdebbieozment.

“Dead butt syndrome”—you probably already have it; Over half of Americans with uncontrolled hypertension are unaware of their condition; Is a smartwatch app for continuous blood pressure monitoring ready for primetime? What are frequent causes of errors in blood pressure measurement? How long can you continue to take Prolia? What's the likelihood of a colon adenoma turning cancerous? Metformin scores cognitive and anti-aging benefits in monkeys—human trials underway. 

Welcome to the Green Rush, a weekly conversation at the intersection of cannabis, psychedelics, the capital markets, and culture, produced by KCSA Podcast Labs. Today, we have a special episode featuring our newest production, Alternatively Speaking. In our debut season, we're diving into a revolutionary concept in health span, longevity, and healthcare. We met with Dr. Nir Barzilai, director of the Institute for Aging Research at the Albert Einstein College of Medicine and the Director of the Paul F. Glenn Center for the Biology of Human Aging Research and of the National Institutes of Health's (NIH) Nathan Shock Centers of Excellence in the Basic Biology of Aging. Dr. Barzilai discovered the first “longevity gene” in humans. His research established that the gene variant that leads to high HDL, or “good cholesterol,” is linked to healthy aging and extreme longevity.  Treatments for age-related diseases like type 2 diabetes are being developed based on Dr. Barzilai's work and are currently in clinical trials. In addition to his “longevity gene” research, Dr. Barzilai studies key mechanisms involved in the biology of aging, including how nutrients and genetics influence lifespan. He is also investigating the physical and mental declines associated with aging and how they affect longevity. Dr. Barzilai is professor of medicine (endocrinology) and of genetics, a member of the Diabetes Research Center, and director of the Diabetes Research and Training Center's Animal Physiology core. Podcast Highlights: Introduction & Dr. Nir Barzilai's Groundbreaking Discovery (00:00 - 03:15): Overview of Dr. Nir Barzilai's discovery of the first “longevity gene” in humans and its link to healthy aging. Discussion on the significance of high HDL cholesterol and how it relates to extreme longevity. The Science Behind Longevity Genes (03:16 - 08:32): Dive into the specific genetic markers that contribute to longevity. Dr. Barzilai shares insights on the mechanisms of aging and the potential to delay or reverse age-related diseases. Current Clinical Trials on Age-Related Diseases (08:33 - 12:10): An exploration of the treatments for type 2 diabetes and other age-related conditions that are being developed from Dr. Barzilai's research, with an update on the progress of these clinical trials. Nutritional and Genetic Influence on Lifespan (12:11 - 17:48): How both genetics and nutrition shape our healthspan and longevity. Dr. Barzilai explains the latest findings on how diet can influence aging and the role of genetics in extending life. Mental and Physical Decline in Aging (17:49 - 21:22): Discussion on the common declines in physical and mental health with aging, and how they impact longevity. Dr. Barzilai talks about ongoing research into mitigating these declines. Future of Longevity Research (21:23 - 26:55): Dr. Barzilai shares his vision for the future of aging research, focusing on potential breakthroughs in longevity science. Social Media: @NirBarzilaiMD: https://x.com/nirbarzilaimd?lang=en  https://www.linkedin.com/in/nir-barzilai-7a86a7212/  Other Links/Mentions/Resources: Age Later by Nir Barzilai, M.D. https://us.macmillan.com/books/9781250230867/agelater  Albert Einstein College of Medicine https://einsteinmed.edu/faculty/484/nir-barzilai  American Federation for Aging Research (AFAR) https://www.afar.org/ Aging is a Treatable Condition - Worth.com The 4 most promising anti-aging drugs investors are sleeping on, according to a leading longevity researcher - Business Insider What is your Biological Age? - The New York Times Show Credits: This episode was hosted by Anne Donohoe and Phil Carlson of KCSA Strategic Communications.  Special thanks to our Program Director, Shea Gunther, and Executive Producer, Maria Petsanas. You can learn more about how KCSA can help your cannabis and psychedelic companies by visiting www.kcsa.com or emailing greenrush@kcsa.com.

Today I have a special episode with Marc Bernegger. We are discussing an event that I am going to be speaking at, The Longevity Investors Conference later this month in Switzerland! Other incredible speakers will be: David A. Sinclair, A.O., Ph.D. Dr. Nir Barzilai, MD Dr. Aubrey de Grey Bryan Johnson Dr. David Furman + so many more! About Longevity Investors Conference ​ ​Longevity Investors Conference is the world's most private investor conference in the longevity space.  The main aim of the event is to bring together the world's top longevity key opinion leaders, institutional and private investors, wealthy private investors, family offices and funds to discuss the latest trends, and opportunities and to provide relevant insights into the longevity and rejuvenation subject. The 2.5 day conference is taking place in a private and exclusive setting of a 5* luxury hotel in Gstaad. Longevity will be one of the largest, if not the largest, investment opportunity in the decades to come. Learn more here!

Kim takes you to the next level of health and performance without the standard prescription of hours of cardio or chicken and broccoli.With laser focus on what has been proven to work for improved performance, sleep, cognitive function, metabolic health and stress levels, you will get maximum results with minimum effort. Work smarter, not harder to make your body look and perform the way you intend it to.The Fabulous in 15 approach is a minimalist protocol that takes you from stressed and tired to vibrant and energetic in the shortest possible amount of time. Check out these other great views as well:Interview with Aubrey De Grey: https://youtu.be/DHvoPlcWwg4Interview with George Church: https://youtu.be/yNplpykf0B4Interview with Lisa Fabiny-Kiser: https://youtu.be/bE5jEGE5-OMInterview with Matt Kaeberlein: https://youtu.be/9QJ_ak3a05QInterview with Nir Barzilai : https://youtu.be/LuOAShcjOt0Interview with Michael Levin : https://youtu.be/5XvDdbYzwf8. PODCAST INFO:The Learning With Lowell show is a series for the everyday mammal. In this show we'll learn about leadership, science, and people building their change into the world. The goal is to dig deeply into people who most of us wouldn't normally ever get to hear. The Host of the show – Lowell Thompson- is a lifelong autodidact, serial problem solver, and founder of startups. LINKSSpotify: https://open.spotify.com/show/66eFLHQclKe5p3bMXsCTRHRSS: https://www.learningwithlowell.com/feed/podcast/Youtube: https://www.youtube.com/channel/UCzri06unR-lMXbl6sqWP_-QYoutube clips: https://www.youtube.com/channel/UC-B5x371AzTGgK-_q3U_KfAWebsite: https://www.learningwithlowell.com Kim rahir linkshttps://kimrahir.com/https://www.linkedin.com/in/kim-rahir/?originalSubdomain=eshttps://www.instagram.com/kim.rahir/?hl=en Timestamps / chapters00:00 Start00:05 Kim Rahir00:50 Accomplishments after MS diagnosis / Olympic weight lifting02:04 Olympic weight lifting03:00 Deadlift04:30 Powerlifting07:55 Mike Tyson, Adversity and training10:10 Rejuvenating after training13:00 Getting through lack of motivations / 5 minute rule16:55 Only 5 minutes19:15 Lifelong learning24:20 Wheelchair to power lifting29:40 MS32:55 202434:55 Dream number36:55 Meditation / mindfulness39:00 Learn mediation / headspace41:45 Strength training43:40 Weeks until getting better45:55 Train to failure48:00 Health and energy focused49:30 Time intensity52:40 Diet / food!54:55 Family dinners and not over eating57:55 Celebrities / interesting meals01:01:45 Community01:05:10 Saying what you want01:08:55 how to get family on board01:11:30 Women vs men advantages and disadvantages01:13:10 Adversity01:14:30 Self Advocacy / MS diagnosis01:22:00 Post having kids01:23:55 One thing you can do right now01:24:55 Her Clients01:25:40 Thank you for all the fish weightlifting #multiplesclerosis #olympicweightlifting

Dr. Peter Lidsky posits that aging is not merely a process of accumulating damages, as commonly believed, but rather a programmed adaptation akin to a part of the immune system. His hypothesis suggests that aging evolved to eliminate older individuals who might be susceptible to severe chronic diseases. Check out these other great views as well:Interview with Aubrey De Grey: https://youtu.be/DHvoPlcWwg4Interview with George Church: https://youtu.be/yNplpykf0B4Interview with Lisa Fabiny-Kiser: https://youtu.be/bE5jEGE5-OMInterview with Matt Kaeberlein: https://youtu.be/9QJ_ak3a05QInterview with Nir Barzilai : https://youtu.be/LuOAShcjOt0Interview with Michael Levin : https://youtu.be/5XvDdbYzwf8 About the showThe Learning With Lowell show is a series for the everyday mammal. In this show we'll learn about leadership, science, and people building their change into the world. The goal is to dig deeply into people who most of us wouldn't normally ever get to hear. The Host of the show – Lowell Thompson- is a lifelong autodidact, serial problem solver, and founder of startups. Learning with lowell linksYoutube: https://www.youtube.com/channel/UCzri06unR-lMXbl6sqWP_-QYoutube clips:https://www.youtube.com/channel/UC-B5x371AzTGgK-_q3U_KfAWebsite: https://www.learningwithlowell.com/ Peter Lidsky linkshttps://twitter.com/LidskyPeterhttps://www.linkedin.com/in/peter-lidsky-71997540 Timestamps00:00 Start00:10 who is Peter Lidsky / research / longevity01:30 Academia differences04:20 Aging explained and the Squirrel test07:20 Pathogen control hypothesis15:50 Lifespans different organisms (fanq)17:55 Natural experiments to prove/disprove (fanq)24:30 Implications of Theory of aging25:00 Senescent cells31:32 Therapeutics / interventions from his research33:00 Implications of his theory37:50 Limits of aging40:10 What do people need to see to believe his theory44:30 Show him the drug that is better than rapamycin46:40 Data sharing / organization to push forward48:50 What is slowing aging research49:50 Pleiotropic genes / aging52:00 Research at Hong Kong52:40 Focus of future research53:55 Devices for research56:00 Bryan Johnson Blueprint59:20 People to follow01:00:00 place to stay up to date01:01:30 Thanks for all the fish longevity #aging #agingresearch

“My long-term goal is to model the pathways involved in human aging in order to develop therapeutic interventions. I organize an annual aging conference in the Midwestern United States with the dual goal of promoting the aging as an adaptation theory and promoting the aging as a disease mindset. The conference website is curing-aging.com.” Check out these other great views as well:Interview with Aubrey De Grey: https://youtu.be/DHvoPlcWwg4Interview with George Church: https://youtu.be/yNplpykf0B4Interview with Lisa Fabiny-Kiser: https://youtu.be/bE5jEGE5-OMInterview with Matt Kaeberlein: https://youtu.be/9QJ_ak3a05QInterview with Nir Barzilai : https://youtu.be/LuOAShcjOt0Interview with Michael Levin : https://youtu.be/5XvDdbYzwf8. PODCAST INFO:The Learning With Lowell show is a series for the everyday mammal. In this show we'll learn about leadership, science, and people building their change into the world. The goal is to dig deeply into people who most of us wouldn't normally ever get to hear. The Host of the show – Lowell Thompson- is a lifelong autodidact, serial problem solver, and founder of startups. LINKSSpotify: https://open.spotify.com/show/66eFLHQclKe5p3bMXsCTRHRSS: https://www.learningwithlowell.com/feed/podcast/Youtube: https://www.youtube.com/channel/UCzri06unR-lMXbl6sqWP_-QYoutube clips: https://www.youtube.com/channel/UC-B5x371AzTGgK-_q3U_KfAWebsite: https://www.learningwithlowell.com David Katz linkshttps://www.linkedin.com/in/davidwarrenkatz/https://www.youtube.com/watch?v=zhbOo_INMwg&t=65s&ab_channel=CuringAginghttps://www.curing-aging.com/ Timestamps00:00 start00:20 Programed aging hypothesis explained01:20 Michael Levin / bioelectricity02:15 Telomerase / concerns around copies of copies04:15 Ability for immortality in animals04:44 Immortal jellyfish06:02 Butterfly brains06:40 Programmed aging in practice for therapies07:16 FDA aging as a disease08:33 Curing aging objectionable09:15 We need to work against our bodies10:18 Fasting / Michael Rae / Caloric restriction11:55 Highly against Richard Dawkins selfish gene and ideas around evolution13:20 Start of slides13:50 Why do we age / David's argument18:20 Different types of aging23:20 Induce damage to test hypothesis25:10 David St Clair work26:20 Evolution has consistently selected for aging29:20 Aging and cancer30:00 exponential population growth31:00 Evolution as an ecological thing32:00 Animals getting bigger and smaller on small island / evolution as multivariable equation35:11 Mole Rats and rats36:25 people who get castrated live longer37:22 Bryan Johnson / interfering with body38:00 Testosterone / women live longer39:22 Mechanism of the body working against itself40:15 Easy interventions / keeping track of time for puberty, death, etc44:30 Squirrels having a year long internal clock46:00 Uniform life events / aging clock / evidence that convinces people50:50 ATF4 Pathway / muscle mass52:00 Not even trying to make therapies ATF454:40 Developing therapies against the body55:30 VCs at conference56:10 Exploring this hypothesis58:40 Tricking body to “think” it's younger59:10 Aubrey De Grey like hallmarks of aging clock1:00:00 Epigenetic clocks / biologic clocks01:01:30 Disrupting dreams / sleep01:02:50 Sleep affecting aging01:04:08 People who stop sleeping die within a number of weeks01:04:40 Does the biological clock have state and turning it back01:10:20 Steel man argument against the Programed aging hypothesis01:10:55 A good case for the clock / time of day, year, and stage of year01:13:00 Dolphins and sleep01:13:30 Target therapy with this theory01:15:40 Children's hospital01:16:05 Kids better able to fight off cancer / medicine divided01:17:11 PhD Tensor decomposition presentation / fundamental relationship of matrices01:18:40 implications and pushback for the tensor decomposition01:19:30 What are the trade offs / stop measuring algorithms based off complexity01:21:18 Real life example / chromosomes01:24:30 SENS and the human genome li...

Former House Speaker Newt Gingrich, author of March to the Majority and host of Newt's World, joins Jamie to debate foreign policy, Donald Trump, the media, and coup d'états. The Agenda: —The preservation of Israel —Going all in on Ukraine —What Never Trumpers miss about Donald Trump —Who is the “establishment” and who is not? —The assassination attempt —How will history remember January 6 —The left-wing drift of the media —Was Joe Biden forced out by a coup? —Technological and biological advances Show Notes: —Letters of Jonathan Netanyahu —A trio of books on real age: Michael F. Roizen's The Great Age Reboot, Nir Barzilai's Age Later, and David Sinclair's Lifespan —Peter Drucker's The Effective Executive —Arnold Toynbee's A Study of History The Dispatch Podcast is a production of The Dispatch, a digital media company covering politics, policy, and culture from a non-partisan, conservative perspective. To access all of The Dispatch's offerings—including members-only newsletters, bonus podcast episodes, and weekly livestreams—click here. Learn more about your ad choices. Visit megaphone.fm/adchoices

This week Dr. Johanan Rand makes his fourth appearance on the Industrial Strength Show. Dr. Rand is the founder of Healthy Aging Medical Centers, located in NJ. He trained at the prestigious Albert Einstein Medical Center in N.Y. and only practices Peer-Review evidence based medicine. On today's show you'll hear Dr. Rand discuss a number of important topics. HIGHLIGHTS INCLUDE: Why do "healthy" people [who get routine blood work] have heart attacks?; Is there a better way to screen people and assess their risk for CV disease [compared to what most doctors are currently doing]?; Is "ApoB" the new gold standard for assessing CV disease risk?; What's the difference between "ApoA" & "ApoB"?; The optimal triglyceride to HDL ratio; Knowing your calcium score; Does Dr. Rand ever prescribe statins?; The history of rapamycin and why it's linked to longevity; How mTOR drives aging...And Much MORE! *For a full list of Show Notes + Timestamps visit www.IndustrialStrengthShow.com. IMPORTANT LINKS / PEOPLE MENTIONED Healthy Aging Medical Centers Cleerly test GlycanAge test Age Later (by Nir Barzilai, M.D.) Rapamycin: mTOR, Autophagy & Treating mTOR Syndrome (by Ross Pelton) Peter Attia (@peterattiamd) BON CHARGE [Use code: JOED]

This week Dr. Johanan Rand makes his fourth appearance on the Industrial Strength Show. Dr. Rand is the founder of Healthy Aging Medical Centers, located in NJ. He trained at the prestigious Albert Einstein Medical Center in N.Y. and only practices Peer-Review evidence based medicine. On today's show you'll hear Dr. Rand discuss a number of important topics. HIGHLIGHTS INCLUDE: Why do "healthy" people [who get routine blood work] have heart attacks?; Is there a better way to screen people and assess their risk for CV disease [compared to what most doctors are currently doing]?; Is "ApoB" the new gold standard for assessing CV disease risk?; What's the difference between "ApoA" & "ApoB"?; The optimal triglyceride to HDL ratio; Knowing your calcium score; Does Dr. Rand ever prescribe statins?; The history of rapamycin and why it's linked to longevity; How mTOR drives aging...And Much MORE! *For a full list of Show Notes + Timestamps visit www.IndustrialStrengthShow.com. IMPORTANT LINKS / PEOPLE MENTIONED Healthy Aging Medical Centers Cleerly test GlycanAge test Age Later (by Nir Barzilai, M.D.) Rapamycin: mTOR, Autophagy & Treating mTOR Syndrome (by Ross Pelton) Peter Attia (@peterattiamd) BON CHARGE [Use code: JOED]

“We have to spend time on our health rather than spend time on diseases," says Nir Barzilai, M.D. Nir, a renowned longevity researcher, joins us to discuss pharmaceutical interventions to delay aging, plus: - What are gerotherapeutics? (~00:19) - What you need to know about antagonistic nutrients (~04:25) - Why healthcare costs don't have to increase as people live longer (~08:55) - SuperAgers vs. Blue Zones (~12:40) - What are some science-backed longevity genes? (~15:14) - The hallmarks of aging (~19:54) - How metformin extends longevity (~22:46) - Who is the right candidate for longevity drugs? (~25:03) - The best age to take a longevity drug (~31:55) - Lifestyle interventions for healthy aging (~34:17) - Is fasting actually necessary? (~38:18) - What to know about mTOR (~41:19) - How to test your biological age (~43:10) - What to do in your 20s and 30s for healthy aging (~48:16) - The role of mindset in aging (~53:45) - How repurposing drugs has saved lives (~57:45) - Why women have the aging advantage (~01:03:42) Take 25% off vitamin D3 potency+ with code D3POD. Cannot combine with gift cards or other discount codes. Apply code at checkout. Referenced in the episode: - Nir's book, Age Later - Nir's SuperAger study - The SuperAgers family study - Learn about the antagonistic pleiotropy hypothesis of aging - Nir's study on metformin & aging - TAME trial - A study on metformin & COVID outcomes - A study on metformin & muscle hypertrophy - Nir's study on organ aging - A study on metformin & IGF1 - A study on centenarians & IGF1 - Episodes #363, #217 & #170, with David Sinclair, Ph.D. - Episode #207, with David Fajgenbaum, M.D., MBA, M.Sc., FCPP We hope you enjoy this episode, and feel free to watch the full video on YouTube! Whether it's an article or podcast, we want to know what we can do to help here at mindbodygreen. Let us know at: podcast@mindbodygreen.com. Learn more about your ad choices. Visit megaphone.fm/adchoices

Unlock the mysteries of aging with our fascinating guest, Dr. Nir Barzilai, as we embark on a journey through the science of longevity. This episode promises to reveal the biological secrets that could redefine your approach to living a long, healthy life. Dr. Barzilai, with his wealth of knowledge, decodes the process of antagonistic pleiotropy where the very mechanisms that protect us in youth may become our foes in old age. Together we scrutinize inflammation's role in aging, explore the intertwining of nutrition and longevity, and ponder the potential of targeting aging to preempt age-related diseases. Our conversation navigates through the nuances of intermittent fasting and the surprising health benefits of a 16:8 fasting routine, offering personal insights and strategies that have become integral to our lives.Some of the topics we will discuss are:- Secrets of Longevity- Tips on how to slow down aging- Does intermittent fasting help with longevity?When it comes to the tapestry of longevity, the threads are as complex as they are colorful. Dr. Barzilai sheds light on the unexpected shifts in personality among centenarians and the enigmatic cerebellum, which suggests a mind-boggling 400-year lifespan prediction according to epigenetic markers. We traverse the landscape of aging biomarkers, debating the merits of proteomics over methylation and the transformative potential of metformin beyond its conventional uses. The episode is studded with revelations—from the role of the TAME trial in ushering in a new era of gerotherapeutics to the promise held by mitochondrial derived peptides and hyperbaric oxygen therapy. This is the frontier of science where the aging process itself is the adversary we learn to outmaneuver.Lastly, we venture into the realm of personal health strategies, where sleep, fasting, and the judicious use of supplements play starring roles. With Dr. Barzilai's guidance, we confront the challenges of achieving ketosis and navigate the complexities of the supplement industry in search of reliable data. Through the lens of the Healthy Longevity Medicine Society, we glimpse into the future of longevity biotech—a future rife with opportunities for both medical professionals and investors. This episode isn't merely a treasure trove of information; it's a call to action for anyone intent on curating a healthier, more vibrant life. Join us as we map out the steps toward not just a longer*** CONNECT WITH ROB ON SOCIAL MEDIA ( 250k++)*** Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/RobertLufkinMDInstagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/Facebook: https://www.facebook.com/robertlufkinmd Threads: https://www.threads.net/@robertlufkinmd *** SPONSORSHIPS & BRANDS ***We do work with sponsors and brands. If you are interested in working with us for your health industry product or service, please contact us at: https://www.robertlufkinmd.com/contact/NOTE: This is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have. Never disregard professional medical advice or delay in seeking it becaus...

We've been hunting for the fountain of youth for millennia, but if you go online, it looks like the search is over! So we're looking at some of the buzziest anti-aging hacks out there: the potential powers of young blood, the latest supplements, and a drug that has some scientists really pumped. We talk to researchers Dr. Jim White, Dr. Melanie McReynolds and Prof. Nir Barzilai.  Find our transcript here: https://bit.ly/ScienceVsAnti-Aging In this episode, we cover: (00:00) The Hunt for the Fountain of Youth (03:07) Can Young Blood Keep Us Sprightly? (13:05) Do NAD Boosters Work?  (21:25) Is Metformin a Game-Changer? (27:50) How the Nerds Stay Young This episode was produced by Michelle Dang and Wendy Zukerman, with help from Meryl Horn, Rose Rimler, and Joel Werner. We're edited by Blythe Terrell. Research help from Timmy Broderick. Fact checking by Eva Dasher. Mix and sound design by Bobby Lord. Music written by Bumi Hidaka, Emma Munger, Peter Leonard, So Wylie and Bobby Lord. A special thanks to all of the researchers we spoke to for this episode, including Dr. Janet Choi, Dr. Gideon Meyerowitz-Katz, and Dr. Xue Li. A special thanks to the Zukerman Family and Joseph Lavelle Wilson. Science Vs is a Spotify Studios Original. Listen for free on Spotify or wherever you get your podcasts. Follow us and tap the bell for episode notifications.  Learn more about your ad choices. Visit podcastchoices.com/adchoices

Aging is inevitable, but can we influence how we age? In this episode of Longevity by Design, hosts Dr. Gil Blander and Ashley Reaver, MS, RD, CSSD,  interview Dr. Nir Barzilai—the Director of the Institute for Aging Research at the Albert Einstein College of Medicine and the Director of the Paul F. Glenn Center for the Biology of Human Aging Research and of the National Institutes of Health's (NIH) Nathan Shock Centers of Excellence in the Basic Biology of Aging—during which he discusses groundbreaking research on aging. This is an enlightening discussion with Dr. Barzilai on factors influencing healthspan and lifespan, and the paradigm-shifting idea of targeting aging to extend healthspan and lifespan. He shares fascinating insights from his research on the influence of genetics and lifestyle on healthspan and lifespan, and blood biomarkers of aging. The conversation sheds light on the emerging scientific evidence and paradigm-shifting concept for medical interventions (gerotherapeutics) to extend healthspan and lifespan by targeting the underlying biology of aging.The episode wraps up with actionable insights for listeners interested in enhancing their healthspan and longevity. Dr. Barzilai discusses the importance of personalized health strategies, integrating cutting-edge research with everyday health practices while emphasizing the importance of a holistic approach. As a listener, you will leave equipped with knowledge and science-backed ways to navigate your personal health journey and help you live healthier longer.Timestamps:Introduction: 00:00-04:13Why Dr. Barzilai's studies centenarians and their children?: 04:14-10:07 Do centenarians live longer with poor health or live healthier longer? 10:08-13:07Does becoming a centenarian have a strong genetic influence?: 13:08-15:41How do growth hormone and IGF-1 affect healthspan and lifespan?: 15:32-23:39What other genes affect healthspan and lifespan?: 23:40- 26:51Does low IGF-1 negatively impact muscle and physical functioning?: 26:52-28:40What are the effects of ethnicity and socioeconomic status on longevity: 28:41-30:57What is the effect of lifestyle, nutrition, and exercise on the longevity of centenarians?: 30:58-34:07Do women or men live longer?: 34:08-37:55Why do women live longer than men?: 37:56-41:38Biomarkers of aging and biomarkers of organ aging: 41:39-47:07What is metformin, and what is the purpose of the TAME trial?: 47:08-51:37Do you think metformin will improve healthspan and lifespan?: 51:38-54:20Does metformin only improve blood glucose control, or does it benefit health and aging in other ways? 54:21-56:50Is metformin good for older adults but not young adults?: 56:51-57:45How does the combination of metformin and exercise impact muscle size (hypertrophy) and strength?: 57:46-01:00:45Should everyone take metformin?: 01:00:46-01:03:13Dr. Gil Blander's and Dr. Nir Barzilai's personal humorous anecdotes on exercise: 01:03:14-01:04:32Is there a reason and explanation for why metformin did not show an effect on lifespan in mice in the Interventions Testing Program (ITP)?: 01:04:33-01:07:01Are GLP-1 agonists beneficial for healthspan and lifespan?: 01:07:02-01:10:55Are there tradeoffs with using GLP-1 agonists?: 01:10:56-01:11:43What are the top 5 gerotherapeutic candidates for improving healthspan and lifespan?: 01:11:44-01:15:10Dr. Nir Barzilai's top tip for improving health: 01:15:11-01:19:29

View the Show Notes For This EpisodeGet Free Weekly Health Tips from Dr. HymanSign Up for Dr. Hyman's Weekly Longevity JournalGet Ad-free Episodes & Dr. Hyman+ Audio ExclusivesDr. Nir Barzilai is a geroscientist, Chaired Professor of Medicine and Genetics, and the founder and principal investigator of the Einstein Nathan Shock Center and the Glenn Center for Excellence in Biology of Aging. He also studies families of centenarians that have provided genetic and biological insights on the protection against aging—with several drugs developed based, in part, on these paradigm-changing studies. He is also leading the TAME (Targeting/Taming Aging with Metformin) trial to prove to the FDA that aging can be delayed and to allow for next-generation interventions. This episode is brought to you by Sunlighten, Cozy Earth, BiOptimizers, and Fatty 15.For a limited time, you can save up to $600 on a Sunlighten infrared sauna. Just go to sunlighten.com/mark-hyman and mention my name.Right now, you can save 40% when you upgrade to Cozy Earth sheets. Just head over to CozyEarth.com and use code DRHYMAN.Tackle an overlooked root cause of stress with Magnesium Breakthrough. Visit bioptimizers.com/hyman and use code HYMAN10 to save 10% and get a free gift with purchase.Fatty15 contains pure, award-winning C15:0 in a bioavailable form. Get an exclusive 10% off a 90-day starter kit subscription. Just visit Fatty15.com and use code DRHYMAN10 to get started.In this episode we discuss (audio version / Apple Subscriber version):The hallmarks of aging (9:01 / 7:10)What causes the hallmarks of aging? (15:40 / 13:49)Dr. Barzilai's research on centenarians (23:16 / 21:25)Why living to 100+ years is good for the economy (24:54 / 23:03)What enables someone to live to 100 years old? (29:30 / 25:20)Taking growth hormone and Metformin have different effects based on your age (36:58 / 32:48)The connection between HDL cholesterol and longevity (43:36 / 39:26)Dr. Barzilai's research on Metformin (56:23 / 52:13)How Metformin works in the body and on muscle growth (1:04:51 / 1:00:41)Dr. Barzilai's personal longevity (1:42:05 / 1:37:55)Learn more about the Longevity Genes Project and the TAME Trial. Get a copy of Age Later: Health Span, Life Span, and the New Science of Longevity Hosted on Acast. See acast.com/privacy for more information.

Here's hoping you and yours enjoyed a lovely Halloween! This episode is going live on November 1, traditionally the Day of the Dead: so I've been overthinking about a news article I read not long ago about a very rich, very determined man who is convinced he's got a plan that will allow him to beat the Grim Reaper — forever.Not only that, but his body — including his man parts — are going to revert to age 18 and stay that way. That is, if his algorithm works the way it's supposed to.Most of the information  and quotes in this episode are taken from a profile of Bryan Johnson written by Time correspondent Charlotte Alter:"The Man Who Thinks He Can Live Forever", Time Magazine, September 20, 2023Also referenced:Nir Barzilai, M.D., Albert Einstein College of MedicinePinchas Cohen, M.D., Dean, Leonard Davis School of Gerontology, University of Southern California Blueprint Protocol: BryanJohnson.comarguably immortal jellyfish: Turritopsis dorhrniiOpening Music by Pixabay MusicSupport the showDo you have comments to share or an idea for an upcoming episode? Need something overthought? I'd love to hear from you!Email me at HeresAThought8@gmail.comOr, contact me on my website at www.JanMFlynn.netOr, DM me on Twitter: @JanMFlynnAuthorTheme music courtesy of Pixabay Music

Dr. Sofiya Milman, MD, MS ( https://www.einsteinmed.edu/faculty/12865/sofiya-milman/ ) is an Associate Professor of Medicine in the Division of Endocrinology and Geriatrics, and is the Director of Human Longevity Studies at the Institute for Aging Research, at Albert Einstein College of Medicine. Dr. Milman's research focuses on a unique population of centenarians and their families ( https://www.superagersstudy.org/ ) who are generally free of age-related diseases, where extreme healthy longevity runs in most of these families, suggesting a heritable basis for this phenomenon. Dr. Milman's team conducts translational research focused on the discovery of genomic mechanisms that regulate endocrine and metabolic pathways that protect against common age-related diseases, like diabetes, cardiovascular disease and Alzheimer's. Dr. Milman became fascinated by both physiology and genetics during her college years and at SUNY Stonybrook School of Medicine, from which she received her medical degree. Following internal medicine residency and fellowship in endocrinology, both at Montefiore, the opportunity arose to combine her passions for physiology and genetics through work with Dr. Nir Barzilai, MD, Director of Institute for Aging Research, the Nathan Shock Center of Excellence in the Biology of Aging, and of the Glenn Center for the Biology of Human Aging at Einstein. During her two years of post-doctoral training in translational gerontology and genetics at Einstein's Institute for Aging Research under Dr. Barzilai's mentorship, she got hooked on the study of aging and found what has become her life's work. Support the show

Jan Vijg, a foremost expert on DNA, aging, and the cutting edge of innovation. His lab at  Albert Einstein College of Medicine studies the process of human aging, its causal mechanisms, and how these mechanisms limit the life span of our species. They are particularly interested in the role of genome instability in aging and cancer. Newsletter sign up (new and exciting developments) https://learningwithlowell.us12.list-manage.com/subscribe?u=08ed8a56013d8b3a3c01e27fc&id=6ecaa9189b Join this channel to get access to perks: https://www.youtube.com/channel/UCzri06unR-lMXbl6sqWP_-Q/join Over 321 books from 170 plus interviews over 5 years https://www.learningwithlowell.com/over-321-books-from-170-interviews-over-5-years-for-autodidacts/ https://youtu.be/UBD9V5oRQdM PODCAST INFO: The Learning With Lowell show is a series for the everyday mammal. In this show we'll learn about leadership, science, and people building their change into the world. The goal is to dig deeply into people who most of us wouldn't normally ever get to hear. The Host of the show – Lowell Thompson- is a lifelong autodidact, serial problem solver, and founder of startups. LINKS Spotify: https://open.spotify.com/show/66eFLHQclKe5p3bMXsCTRH RSS: https://www.learningwithlowell.com/feed/podcast/ Youtube: https://www.youtube.com/channel/UCzri06unR-lMXbl6sqWP_-Q Youtube clips: https://www.youtube.com/channel/UC-B5x371AzTGgK-_q3U_KfA Website: https://www.learningwithlowell.com/ Jan Vijg links https://www.einsteinmed.edu/faculty/11318/jan-vijg/ https://www.vijglab.org/jan Timestamps 01:00 Greatest Achievements 07:10 AI/ML  Innovation / stagnation 12:30 Profitability and innovation  17:30 Outliers / Elon Musk / Steve Jobs 21:30 Complexity and innovation 23:40 Science and incremental innovation / CRISPR 24:50 Full Funding affecting research 26:10 Team members needed for his research 29:30 Errors, trust system, and proper research 32:10 Complex parts of Jan's research / DNA artifacts & mutations 34:15 Advantage of error rate / mutation in dna  39:10 Cells being naturally immortal / Aging / Longevity 45:00 Centaurians, Nir Barzilai, DNA error rate / animal frequency DNA errors  46:40 Results of increasing mutation rate to determine affects on longevity and aging 52:30 Research partnerships /projects since 1999 55:05 10 more years of research 56:30 His research and determining diagnostics / spin offs / treatments  01:01:50 Dieting, aging, life span differences  01:06:30 Science evolving humans 01:09:30 Eye surgery feeling 01:11:50 Oppenheimer as greatest scientist  01:12:14 Book Recommendations 01:19:45 India and China science institutions  01:22:20 Warring state period / world wars 01:23:15 Book release date / Kissenger  01:27:30 Structures of society  01:32:20 Modern china, culture, organ harvesting 01:36:30 Ways to stay up to date

In this episode, discover the intriguing world of longevity and biohacking with Dr. Sanjeev Goel, an expert in anti-aging, to explore the potential of Metformin for extending lifespan. Should we embrace its potential benefits? We address this burning question and discuss Metformin's origin, popularity as a diabetes treatment, and its role in potentially extending lifespan. Discover how this medication, discovered in the 1920s, is now being explored beyond diabetes. We touch on the TAME trial led by Dr. Nir Barzilai, aimed at unraveling Metformin's impact on longevity. Before considering its use, remember that Metformin is a prescription medication, and expert consultation is advised. Join us at peakhuman.ca to stay updated on groundbreaking discoveries. Explore our rewards program for exclusive benefits. Tune in as we continue our quest for peak human well-being!  

Use Code SIIMLAND for 20% OFF InsideTracker: https://info.insidetracker.com/siimland Timestamps: 02:00 Nir's Beginning in Longevity Research 05:00 Fasting and Calorie Restriction in Mice 10:55 Similarities Between Animal and Human Aging 18:25 Tradeoffs in Longevity and Frailty 23:50 Secrets of Long-Living Centenarians 28:20 Genes That Make You Live Longer 32:05 How to Turn On Your Longevity Genes 32:21 Can Metformin Slow Down Aging 43:45 Metformin Side-Effects Nir's Book Age Later: https://amzn.to/44BqX1n The Supplements That Lowered My Age by 12 Years: https://youtu.be/VsZRKvb1Fuo The Diet & Routine That Lowered My Age by 12 Years: https://youtu.be/5KNsfEBXKMg The Workout Plan That Lowered My Age by 12 Years: https://youtu.be/OsVXAW-Tc3Y

In today's episode, I want to share with you the book "Age Later" by Dr. Nir Barzilai.About the Host:Melissa is an Integrative Health Practitioner and Master Practitioner in NLP and Timeline Therapy and a Board Designated Hypnotherapy Teacher Trainer, helping people get to the root cause of their health issues and then get lasting results. Melissa neither diagnoses nor cures but helps bring your body back into balance by helping discover your “toxic load” and then removing the toxins. Melissa offers functional medicine lab testing that helps you “see inside” to know exactly what is going on, and then provides a personalized wellness protocol using natural herbs and supplements. Melissa's business is 100% virtual – the lab tests are mailed directly to your home and she specializes in holding your hand and guiding the way to healing so that you don't have to figure it all out on your own.Melissa is the winner of the 2021 & 2022 Quality Care Award by Business From The Heart and is also the recipient of the Alignable “Local Business Person of the Year “Award 2022 for Whistler.Melissa has been featured at a number of Health & Wellness Summits, such as the Health, Wealth & Wisdom Summit, The Power To Profit Summit, The Feel Fan-freaking-tas-tic Summit, the Aim Higher Summit and many more! She has also guested on over 60 different podcasts teaching people about the importance of prioritizing our health and how to get get started. Linktree: https://linktr.ee/yourguidedhealthjourney Thanks for listening!If you know somebody who would benefit from this message, or would be an awesome addition to our community, please share it using the social media buttons on this page.Do you have some feedback or questions about this episode? Leave a note in the comment section below! Subscribe to the podcast!If you would like to get automatic updates of new podcast episodes, you can subscribe on the podcast app on your mobile device.Leave us a review!We appreciate every bit of feedback to make this a value-adding part of your day. Ratings and reviews from our listeners not only help us improve, but also help others find us in their podcast app. If you have a minute, an honest review on Apple Podcasts/iTunes goes a long way! Thank You!!

Caloric restriction. Blood transfusions. Hormetic stress. Off-label meds. As CNN's Chief Medical Correspondent, Dr. Sanjay Gupta is often asked about the latest “hacks” for longevity that pop up in the news. But do any of these interventions actually work? Can aging actually be stopped, much less reversed? In this episode, Sanjay speaks with Dr. Nir Barzilai, the director of the Institute for Aging Research at the Albert Einstein College of Medicine. He believes one of the keys to battling aging lies in our cells and genetic makeup. Plus, we hear from self-professed “biohackers,” who have some tips we can all try to extend our healthy years.To learn more about how CNN protects listener privacy, visit cnn.com/privacy

We tend to think of getting older as inevitable, but what if it's actually something we can control? Researchers like David Sinclair and Nir Barzilai have discovered some of the secrets to reversing aging, found animals who defy our understandings of life, and turned old mice young again. But even if humans could live forever, should we?

Nir Barzilai is the founding director of the Institute for Aging Research, the Nathan Shock Center of Excellence in the Basic Biology of Aging and the Paul F. Glenn Center for the Biology of Human... Source

In today's podcast episode, I talk with Nir Barzilai, a geroscientist, which means he studies the biology of aging. Barzilai directs the Institute for Aging Research at the Albert Einstein College of Medicine.My first question for Dr. Barzilai was: why do we age? And do we have to age? His answers were encouraging. We can't live forever, but there are a few things we can do to age later, as he argues in the book.He explained that centenarians differ from the rest of us because they have unique gene mutations that help them stay healthy longer. For most of us, the words “gene mutations” spell trouble—we associate these words with cancer or neurodegenerative diseases, but apparently not all mutations are bad. Centenarians may have essentially won the genetic lottery, but that doesn't mean the rest of us are predestined to have a specific lifespan and health span—the amount of time spend living productively and enjoyably. “Aging is a mother of all diseases,” Dr. Barzilai told me. And as a disease, it can be targeted by therapeutics. Dr. Barzilai's team is already running clinical trials on such therapeutics—and the results are promising. More about Dr. Barzilai: He is scientific director of AFAR, American Federation for Aging Research. He is also the author of Age Later.  As part of his work, Barzilai studies families of centenarians and their genetics to learn how the rest of us can learn and benefit from their super-aging. He also organizing a clinical trial that is testing a specific drug that may slow aging. Show LinksAge Later: Health Span, Life Span, and the New Science of Longevity  https://www.amazon.com/Age-Later-Healthiest-Sharpest-Centenarians/dp/1250230853American Federation for Aging Research  https://www.afar.orghttps://www.afar.org/nir-barzilaihttps://www.einsteinmed.edu/faculty/484/nir-barzilai/Metformin as a Tool to Target Aginghttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943638/Benefits of Metformin in Attenuating the Hallmarks of Aging  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347426/The Longevity Genes Project https://www.einsteinmed.edu/centers/aging/longevity-genes-project/Leaps.org is a not-for-profit initiative that publishes award-winning journalism, popularizes scientific progress on social media, and hosts events about bioethics and the future of humanity. Visit the platform at www.leaps.org. Podcast host Matt Fuchs is editor-in-chief of Leaps.org.

Is a miracle drug to reverse aging in the near future? In this second part of a two-part Age Wise interview, Silver Solutions CEO Dan Lagani speaks to Dr. Nir Barzilai, the Scientific Director of AFAR (American Federation for Aging Research), about his revolutionary work to reverse the aging process. Find out about the latest anti-aging research involving Metformin as well as the top three things everyone should be doing to extend their healthspan today (hint: you might want to get out of your right chair now).

In this captivating two-part Age Wise interview, Silver Solutions CEO Dan Lagani delves into the revolutionary thinking of Dr. Nir Barzilai, the Scientific Director of AFAR (American Federation for Aging Research) and the visionary behind the Institute for Aging Research at Albert Einstein College of Medicine. Find out about not only slowing down the aging process but actually reversing it altogether.

We tend to think of getting older as inevitable, but what if it's actually something we can control? Researchers like David Sinclair and Nir Barzilai have discovered some of the secrets to reversing aging, found animals who defy our understandings of life, and turned old mice young again. But even if humans could live forever, should we?

Dr. Nir Barzilai discovered the first “longevity gene” in humans and pioneered key research around the biology of aging. He's the founding director of the Institute for Aging Research at the Albert Einstein College of Medicine in New York and the author of the book Age Later. Nir and Auren discuss the most promising studies and treatments in the field of anti-aging research and break down the major takeaways from Nir's seminal studies on centenarians— why they live longer, and what the rest of us can learn from them. Nir also explains the role of genetics vs. environment in longevity and makes some data-backed recommendations for anyone who wants to live a longer, healthier life. World of DaaS is brought to you by SafeGraph. For more episodes, visit safegraph.com/podcasts.You can find Auren Hoffman on Twitter at @auren and‍ Nir Barzilai on Twitter @NirBarzilaiMD.

Few have a pulse on the science and genetics of aging as Dr. Nir Barzilai. As the director of the Institute of Aging Research at the Albert Einstein College of Medicine, he was the first to discover the “longevity gene” in humans; and in so doing began to hypothesize and demonstrate why centenarians with protective genes live longer, healthier lives and experience far fewer age-related disease. In our conversation, we focus on understanding the correlation between genes, lifestyle, and the resilience of predictable longevity™. Modern science and technology has made it far easier for each of us to take charge of our health; still it requires a major shift in perspective - away from preventing sickness and more towards optimizing well+being. Here are a few of the topics we explore: The barriers to predictable longevity™. The misconceptions of aging. Why anti-aging is its own disease. The genetic code of centenarians. The lifestyle habits that delay aging.

Dr. Nir Barzilai, MD ( https://www.einsteinmed.edu/faculty/484/nir-barzilai/ ) is the Director of the Institute for Aging Research at the Albert Einstein College of Medicine and the Director of the Paul F. Glenn Center for the Biology of Human Aging Research and of the National Institutes of Health's (NIH) Nathan Shock Centers of Excellence in the Basic Biology of Aging. He is the Ingeborg and Ira Leon Rennert Chair of Aging Research, professor in the Departments of Medicine and Genetics, and member of the Diabetes Research Center and of the Divisions of Endocrinology & Diabetes and Geriatrics. Dr. Barzilai's research interests are in the biology and genetics of aging, with one focus of his team on the genetics of exceptional longevity, where they hypothesize and demonstrate that centenarians (those aged 100 and above) may have novel protective genes, which allow the delay of aging or for the protection against age-related diseases. The second focus of his work, for which Dr. Barzilai holds an NIH Merit award, is on the metabolic decline that occurs during aging, and his team hypothesizes that the brain leads this decline with some very interesting neuro-endocrine connections. Dr. Barzilai is currently leading an international effort to approve drugs that can target aging (Gerotherapeutics). Targeting Aging with METformin (TAME) is a specific study designed to prove the concept that a basket of diseases (multi-morbidities) of aging can be delayed simultaneously, in this protocol by the drug metformin, working with the FDA to approve this approach which will serve as a template for future efforts to delay aging and its diseases in humans. Dr. Barzilai has received numerous grants, among them ones from the National Institute on Aging (NIA), American Federation for Aging Research, the Ellison Medical Foundation and The Glenn Medical foundation. He has published over 280 peer-reviewed papers, reviews, and textbook chapters. He is an advisor to the NIH on several projects and serves on several editorial boards and is a reviewer for numerous other journals. Dr. Barzilai is on the board of the American Federation for Aging Research, is it's co-scientific director, and has served on several NIA study sections. He is also a founder of CohBar Inc., a biotech company that develops mitochondrial derived peptides as therapy for aging and it's diseases, and of Life Biosciences. Dr. Barzilai has been the recipient of numerous prestigious awards, including the Beeson Fellow for Aging Research, the Ellison Medical Foundation Senior Scholar in Aging Award, the Paul F. Glenn Foundation Award, the NIA Nathan Shock Award, the 2010 Irving S. Wright Award of Distinction in Aging Research and the IPSEN Longevity Prize (2016). Born in Israel, Dr. Barzilai served as chief medic and physician in the Israel Defense Forces. He graduated from The Ruth and Bruce Rappaport Faculty of Medicine at the Technion-Israel Institute of Technology in Haifa and completed his residency in internal medicine at Hadassah Medical Center in Jerusalem. He served in a refugee camp during the war in Cambodia (1979-1980) and built a nutritional village in the homeland of the Zulu (1983 – Kwazulu). He has completed 2 fellowships at Yale (Metabolism) and Cornell (Endocrinoology and Molecular Medicine).  He has also taken part in Global initiatives and spoke at The Milken Global Institute, Asian Megatrends and is an advisor for the Prime Minister of Singapore on Aging. Dr. Barzilai has been on the ‘Forward 50, top 50 influence Jews" in the US (2011). His work has been profiled by major outlets, including the New York Times, the BBC and PBS' NOVA science now, TEDMED and several TEDx talks, and is the leading feature on the Ron Howard/Jonathan Silberberg/National Geographic film about the Age of Aging. He also authored the book Age Later (2019). Support the show

Christin Glorioso MD, Phd, & founder of NeuroAge Therapeutics and Longevity Global. Today we are digging into the drama of supplements and specifically metformin & Nir Barzilai, research into Alzheimer's, Aubrey De Grey concerns, David Sinclair Yamanaka factor mouse studies explained, Bryan Johnson 2 million a year longevity blueprint, brain age, books, and more.   Also, … Brain Longevity, Supplement concerns, & Alzheimers Drama w/Dr. Christin Glorioso CEO of NeuroAge 156 Read More »

After a wide-ranging conversation with Nir Barzilai, Gordon and show editor Stella discuss efforts to turn research on geroprotective mechanisms into effective interventions, and look forward to the next episode with neuroscientist Monica Driscoll.Support the show

Is aging truly inevitable? Can we study the genetics of long-lived people to learn how to delay or reverse aging? In this episode, Gordon talks with Dr. Nir Barzilai about his research on centenarians, insulin signaling pathways, and moving aging interventions out of the lab and into the clinic. Support the show

Gordon and show editor Stella revisit key concepts from the conversation with Linda Partridge, such as what we can learn from evolutionary biology and how to harness biological processes like autophagy. Looking ahead, they anticipate discussing human clinical trials in the next episode with Nir Barzilai.Support the show

What do we know about the process of aging? What makes some people age quicker than others?  How do we prolong our lives? Newt's guest is Dr. Nir Barzilai. He is a Professor in the Department of Medicine and the Department of Genetics at Albert Einstein College of Medicine.  He is also the Director of the Institute for Aging Research. In the “Longevity Genes Project”, Dr. Barzilai and his team conducted genetic research on more than 500 healthy elderly people between the ages of 95 and 112 and on their children. He is the author of “Age Later: Health Span, Life Span, and the New Science of Longevity.” See omnystudio.com/listener for privacy information.

Start listening to our third audio podcast with Nir Barzilai,The Founding Director of Aging Research at the Albert Einstein College of Medicine in New York.

A rare MD at the cutting edge of the longevity field, Dr. Barzilai heads the Institute for Longevity Research at Einstein. We cover his unique contributions, especially the currently buzzy topic of metformin, as well as his work on the genetic luck of centenarians.

It's typical for athletic performance to decline with age. (And, athletes may experience signs of accelerated aging caused by intense training.) If you're worried about your declining performance, start looking at how you train and what you eat. We may not be able to reverse our chronological age, but we can guide our bodies through the ageing process.  Did you know that there are longevity strategies specifically for athletes? These strategies consider long-term performance, health, and muscle growth!  In this episode, Dr. Elena Seranova joins us to discuss how ageing can affect our bodies and our athletic performance. She shares her strategies, from supplements to lifestyle changes, that can help athletes combat the effects of ageing. If you're overwhelmed by all of the information out there, remember: you need to build a good foundation first. Start with eating right and sleeping well; from there, you can eventually incorporate Dr. Elena's other recommendations. If you want to learn longevity strategies for athletes and how to improve athletic performance, then this episode is for you! Here are three reasons why you should listen to the full episode: Discover how ageing affects athletic performance and why athletes may experience signs of accelerated ageing.  Learn longevity strategies that will support athletic performance and your general health, like how to activate your autophagy pathways. Understand that longevity is a process of building good habits; you can start out by focusing on the basics, like diet and sleep.  Get Customised Guidance for Your Genetic Make-Up For our epigenetics health programme, which is all about optimising your fitness, lifestyle, nutrition and mental performance for your particular genes, go to  https://www.lisatamati.com/page/epigenetics-and-health-coaching/. Customised Online Coaching for Runners CUSTOMISED RUN COACHING PLANS — How to Run Faster, Be Stronger, and Run Longer  Without Burnout or Injuries Have you struggled to fit training into your busy life? Maybe you don't know where to start, or you have done a few races but struggle with motivation or injuries? Do you want to beat last year's time, or finish at the front of the pack? Do you want to run your first 5-km, or run a 100-miler? ​​Do you want a holistic programme that is personalised & customised to your ability, goals, and lifestyle?  Go to www.runninghotcoaching.com for our online run training coaching. Health Optimisation and Life Coaching Are you struggling with a health issue and need people who look outside the square and are connected to some of the greatest science and health minds in the world? Then reach out to us at support@lisatamati.com, we can jump on a call to see if we are a good fit for you. If you have a big challenge ahead, are dealing with adversity or want to take your performance to the next level and want to learn how to increase your mental toughness, emotional resilience, foundational health, and more, contact us at support@lisatamati.com. Order My Books My latest book, Relentless, chronicles the inspiring journey about how my mother and I defied the odds after an aneurysm left my mum, Isobel, with massive brain damage at age 74. The medical professionals told me there was absolutely no hope of any quality of life again. Still, I used every mindset tool, years of research and incredible tenacity to prove them wrong and bring my mother back to full health within three years. Get your copy here: https://shop.lisatamati.com/collections/books/products/relentless. For my other two best-selling books Running Hot and Running to Extremes, chronicling my ultrarunning adventures and expeditions all around the world, go to https://shop.lisatamati.com/collections/books. Lisa's Anti-Ageing and Longevity Supplements  NMN: Nicotinamide Mononucleotide, an NAD+ precursor Feel Healthier and Younger* Researchers have found that Nicotinamide Adenine Dinucleotide or NAD+, a master regulator of metabolism and a molecule essential for the functionality of all human cells, is being dramatically decreased over time. What is NMN? NMN Bio offers a cutting edge Vitamin B3 derivative named NMN (beta Nicotinamide Mononucleotide) that can boost the levels of NAD+ in muscle tissue and liver. Take charge of your energy levels, focus, metabolism and overall health so you can live a happy, fulfilling life. NMN Bio offers pure supplements that are rigorously tested by an independent, third-party lab. Start your cellular rejuvenation journey today. Support Your Healthy Ageing We offer powerful third-party-tested NAD+ boosting supplements so you can start your healthy ageing journey today. Shop now: https://nmnbio.nz/collections/all NMN (beta Nicotinamide Mononucleotide) 250mg | 30 capsules NMN (beta Nicotinamide Mononucleotide) 500mg | 30 capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 250mg | 30 Capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 500mg | 30 Capsules Quality You Can Trust — NMN Our premium range of anti-ageing nutraceuticals (supplements that combine Mother Nature with cutting edge science) combats the effects of ageing, and is designed to boost NAD+ levels. Manufactured in an ISO9001 certified facility. Boost Your NAD+ Levels — Healthy Ageing: Redefined Cellular Health Energy & Focus Bone Density Skin Elasticity DNA Repair Cardiovascular Health Brain Health  Metabolic Health Episode Highlights [02:32] Why Athletic Performance Drops as We Age The main cause of athletic performance decline is mitochondrial decline. Mitochondrial decline is linked to senescence cells.  Senescence cells stop dividing and do nothing. As we age, we may have 5-20% senescence cells in different tissues.  This causes inflammation and causes the mitochondria to function improperly, thus increasing reactive oxygen species within cells.  Nuclear DNA is usually packed in histones, which preserve genetic material. However, mitochondrial DNAs lack histones, making it prone to oxidative stress and mutations.    As we age, our epigenetic processes become less efficient; it becomes a vicious cycle with more reactive oxygen species and less capacity to deal with them.  [08:23] How Else Do Our Bodies Respond to Ageing Ageing declines autophagy, which recycles cellular organelles.  When there's nothing to clean up dysfunctional mitochondria, problems with energy generation arise. Athletes who have exercised intensely their whole life will have worn-off tissues and lactic acid buildup.  Remember, exercise is good, since we want some level of oxidative stress; however, we don't want more oxidative stress than what our body can cope with.  Lisa shares how running ultramarathons accelerated her ageing process, wear and tear, and inflammation.  [12:29] How to Support Autophagy and Athletic Performance?  Intermittent fasting is when people have a certain feeding window a day. After eating, mTOR switches off and AMPK is activated which allows for autophagy.   If you want to build muscle, Dr. Elena recommends eating after exercising so you can activate mTOR which helps with muscle growth.    You need to create a cycle going of mTOR and AMPK since autophagy recycles cells back into amino acids, which can help cells build new proteins.  Don't create a feeding window that's too narrow; you need to have enough fuel for your body. Eat chicken, meat, and foods rich in amino acids.  Make sure you're sleeping properly, as this can affect your muscle growth.  [18:30] Supplements to Support Autophagy and Longevity You can also support autophagy through supplements like berberine.  Dr. Elena recommends adding supplements to specifically target senescence cells. Senolytics help kill senescence cells while senomorphics modify the senescence cells.  Quercetin added with Vitamin C can help kill senescence cells. By itself, quercetin can produce toxic metabolites, so it needs Vitamin C to serve as an antioxidant.  She also recommends taking their quercetin product with NAC and acetylcysteine to boost glutathione, a potent antioxidant.  Quercetin has many benefits including anti-inflammatory properties, and can be used to combat cardiovascular disease, fight seasonal allergies, and can fight cancer.     [26:51] How to Take Quercetin Quercetin can be found naturally in fruits and vegetables like strawberries and onions.  If you've never taken compounds for their senescent action before, start by taking quercetin at 500 mg every day. After a month of taking it, check in on how you feel.  You can also implement detox protocols with a higher dosage of quercetin(around 2 - 2 ½ grams). If you want to implement this protocol, start with 5 days first.  Quercetin can be combined with 500mg of chlorella to boost the detoxifying reaction. People with kidney diseases should consult with a doctor before taking quercetin.   [32:43] How NMN Can Help Athletes  In addition to mitochondrial decline, athletes can experience loss of endurance and muscle loss as they age.  Dr. Elena recommends increasing your fasting window depending on your goals.  You want more oxygenation in your tissues to preserve endurance and muscle.  Dr. Elena offers an NMN product that can increase both endurance and prevent age-related muscle loss.    This can help increase insulin sensitivity, activating longevity genes and DNA repair.  [36:37] How to Optimise NMN  NMN functions optimally when it's attached to a methyl group. Unfortunately, our body's methylation process also declines with age.  NMN should be paired with TMG, as it is a rich methyl donor.  When you combine NMN, TMG, and quercetin, you'll optimise your performance and endurance. [39:11] Longevity is Your Biological Age, Not Your Chronological Age Many people over 40 are insulin resistant. Insulin resistance is a gateway to biological decline.  You can check your insulin resistance by checking your waist to hip ratio.  After the age of 40, it's much easier to experience hormonal dysfunction.  We need to make a conscious effort to improve our health. Ageing can cause issues to spiral if left uncontrolled.   [42:50] Be Careful With Your Food 80% of adults in the west are insulin resistant.  The food industry worsens the condition by offering so many processed carbohydrates.  Many people have false ideas about what a healthy diet is. You can't have too many carbohydrates and sugar, even if they're coming from fruits.  Cut down on carbohydrates, avoid processed foods, and take good oils.  [45:21] Start with the Basics Start with the basics. You don't need to add supplements immediately.  Just eat clean and good food. There's no such thing as a universal diet.  Taking cold showers in the morning can improve hormonal balance. You can start with just 10 seconds of cold exposure.  Manage your stress levels and make sure you move regularly.  You don't need to be perfect.  [50:47] How Some People Live to 100  There were two hypotheses surrounding centenarians: good habits and the absence of high-risk genes. However, some centenarians were found to have bad habits and mutations for Alzheimer's disease.  Centenarians have genes that mitigate risks from bad mutations. They also have low IGF 1 levels.  When people are young, IGF 1 can improve muscle and tissue growth, but it can be harmful when people grow older. Centenarians' genetic combination allowed for IGF to decrease as they grow older. Listen to the episode to learn more about how centenarians' hormonal processes are being regulated. Commit to regularly regulating and balancing your hormones. This process starts with clean food, caloric restriction, and exercise.     About Dr. Elena Dr. Elena Seranova is a scientist, serial entrepreneur, and business mentor. She has now founded multiple innovative biotechnological businesses. She first studied at the University of Ioannina with a major in Psychology. Dr. Elena then started a private practice before developing an interest in neuroscience. Dr. Elena continued her studies and earned her Master's Degree in Translational Neuroscience at the University of Sheffield. She now also holds a Doctorate Degree in Stem Cell Biology and Autophagy from the University of Birmingham. Dr. Elena's expertise in these fields led her to co-found the biotech start-up SkyLab Bio. She has written several peer-reviewed articles on autophagy. Her latest business is NMN Bio. Her own experiences with supplements have inspired her to expand the market to include cutting-edge anti-ageing supplements. NMN Bio reaches New Zealand, the UK, and Europe. Dr. Elena found her passion for drug discovery and autophagy. She has endeavoured to share this with the public through her research and work as an entrepreneur.  To learn more about Dr. Elena and her work, visit NMN Bio. Resources Gain exclusive access and bonuses to Pushing the Limits Podcast by becoming a patron!  Want to learn more from Dr Dom? Check out our previous episode with her:  Episode 238 - Reverse Ageing to Live Longer and Healthier with Dr. Elena Seranova Episode 189: Understanding Autophagy and Increasing Your Longevity with Dr Elena Seranova  Episode 183: Sirtuins and NAD Supplements for Longevity with Dr Elena Seranova        Want to dive deeper into longevity and work out a protocol for yourself? Take the Foundations of Longevity and Life Extension Online Course by Dr Elena Seranova and Jesse Coomer  Deep Nutrition: Why Your Genes Need Traditional Food by Catherine Shanahan, M.D.  Centenarians, metformin, and longevity | Nir Barzilai, M.D., Episode 204 from the Peter Attia podcast  Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38 Therapeutic Potential of Quercetin: New Insights and Perspectives for Human Health Visit NMN Bio to know more about NMN supplements!  

Dr Nir Barzilai is Professor and Founding Director of the Institute for Aging Research at the Albert Einstein College of Medicine and the Director of the Paul F. Glenn Center for the Biology of Human Aging Research and of the National Institutes of Health's (NIH) Nathan Shock Centers of Excellence in the Basic Biology of Aging. Essentially he is an OG (original gangster) in human longevity research. When describing him, David Sinclair writes “Not only is he a world leader in aging research, but also happens to be one of the best science communicators on the planet”. Barzilai is also the author of Age Later: Secrets of the Healthiest, Sharpest Centenarians. He has over 270 peer reviewed papers and also co-founded CohBar, a publicly listed biotech company developing mitochondrial therapies for ageing. In his quest to fight ageing — he has consulted or presented to institutions such as the Vatican, PepsiCo and Singapore's Prime Minister's Office. He also leads the TAME Trial which is looking at a cheap and commonly used diabetes drug called Metformin — to see if it can slow down the process of ageing. Metformin first gained interest in the longevity space, when people began to notice that diabetics on metformin seemed to have lower mortalities than diabetes on other drugs. In fact, diabetics on metformin had lower death rates than similar people — who didn't have diabetes and so were not on metformin. Just to be clear, diabetics on metformin with a serious medical condition — which is one of the big four killers in the developed world — appear to have lower death rates than non-diabetics who aren't taking metformin. That's crazy. In his TAME trial he's investigating if metformin can delay the progression of age related diseases in older adults. Barzilai is part of a movement in longevity research or geroscience, who aim to treat ageing as a disease in itself — instead of treating one disease, only for another to take its place. In a 1990 paper in Science, it was estimated that if we cured all cancers — we would extend the average lifespan by just three years. That's not to say that developing therapies for cancers is wrong, but to really move the needle on health and lifespan extension — we need to think of tackling ageing and not just individual manifestations of ageing such as cancer, diabetes, heart disease and Alzheimers. You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Nir Barzilai, Director of the Institute for Aging Research at the Albert Einstein College of Medicine, is back for his third appearance on The Drive. In this episode, Nir divulges insights into lifespan and healthspan through the lens of his extensive research on centenarians as well as the latest from the TAME trial (Targeting/Taming Aging with Metformin), a multi-center study investigating the concept that the multi-morbidities of aging can be delayed in humans. He discusses common gene variants found in centenarians, important pathways for longevity, and ultimately what we can learn from centenarians about extending lifespan while also trying to improve healthspan. Additionally, Nir goes into depth on metformin as a longevity tool for humans, including studies with positive and negative results. He discusses the impact metformin can have on exercise for both strength training and cardiovascular training, as well as future research facilitated by data from the TAME Trial. He also touches on epigenetic clocks and concludes with his take on the usefulness of NAD precursors as a potential gero-protective agent. We discuss: Insights from genetic studies of centenarians and twins [3:00]; Genes with protective variants that aid longevity [13:00]; The relationship between growth hormone and IGF-1 [22:45]; Use of growth hormone as a longevity tool [34:00]; Longevity genotypes: the role of APOE e2, Lp(a), Klotho, and CETP [41:45]; The correlation between high TSH and longevity [46:30]; Important pathways for longevity [52:00]; Insights from centenarian studies, nature vs. nurture, and more [59:00]; The contraction of morbidity that comes with improved healthspan [1:08:00]; Defining healthspan [1:13:13]; Unique perspectives and positive attitudes of centenarians [1:17:30]; Lessons to take away from centenarians [1:24:00]; Metformin overview: history, studies, and potential for gero-protection [1:28:45]; The TAME trial (Targeting Aging with Metformin) [1:39:00]; The challenge of studying metformin in animals models [1:46:45]; How data from the TAME trial could provide insights into biomarkers of aging and facilitate a future study on proteomics [1:53:30]; The search for biomarkers to identify who can benefit from treatment [2:00:30]; The impact of metformin on exercise, and finding the right indication for the use of metformin [2:10:30]; Are NAD precursors geroprotective? [2:21:30]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube  

Nir Barzilai, M.D. is the director of the Institute for Aging Research at the Albert Einstein College of Medicine. He is also the Director of the Paul F. Glenn Center for the Biology of Human Aging Research and of the National Institutes of Health's (NIH) Nathan Shock Centers of Excellence in the Basic Biology of Aging. Dr. Barzilai's research interests are in the biology and genetics of aging. He is currently leading an international effort to approve drugs that can target aging. Targeting Aging with METformin (TAME) is a specific study designed to prove the concept that multi-morbidities of aging can be delayed by metformin, working with the FDA to approve this approach which will serve as a template for future efforts to delay aging and its diseases in humans. Nir and I Discussed: What is Metformin and what was it previously used for? What does he mean by "cure aging"? Why do your chances of getting sick increase as you grow old Why do women live longer The longevity effects of intermittent fasting How to decipher between good & bad information Can we really extend human life to 200 years or more? And much more... Nir Barzilai My Take: Technology has allowed us all the luxuries that we currently enjoy. Our food, transportation, entertainment, clothes, medicine, communication - and everything else we can think of. Can technology extend human life? Well, it already has. 100 years ago the median age was half what it is now. It will be interesting to see what science will accomplish in the next few years, or decades, with age-related diseases and human longevity. How To Start A Podcast Support The Podcast

As you get older, your chances of getting sick and developing diseases get higher. But what if aging itself is the condition we should be treating? Dr. Nir Barzilai is the founding director of the Institute for Aging Research at the Albert Einstein College of Medicine and the world's leading expert on metformin. Here, he joins host Shaun Francis to discuss the potential of metformin to fight aging, and his new trial that could change the way we view and treat old age.

Aging research is quickly evolving to understand how we can live healthier, longer lives. Scientists are looking to centenarians and their family members to reveal how their environment, lifestyle, and genetics contribute to their delayed aging.In this episode of Longevity by Design, our co-hosts, Dr. Gil Blander and Ashley Reaver, are joined by Dr. Nir Barzilai,  Director of the Institute for Aging Research at the Albert Einstein College of Medicine. Tune in as Dr. Nir Barzilai describes how he pursued a career in aging, where the research stands on metformin and longevity, and the Longevity Genes Project, genome mapping 750 centenarians and their family members to understand the genetic component of aging.To learn more about science-backed ways to live a healthier, longer life, download InsideTracker's InnerAge eBook at insidetracker.com/podcast

Thanks to the application of data and scientific rigor, remarkable gains are being made against one of mankind's most formidable foes: aging. Today's guest is Dr. Nir Barzilai, the founding director for the Institute of Aging Research. In his conversation with host Gregg Fisher, Barzilai breaks down the latest insights in our treatment of the human aging process. Dr. Barzilai distinguishes biological age from chronological age, sharing that the actual number of years healthy human beings are designed to spend on earth is much greater than you think.

The TAME trial and beyond (Dr. Nir Barzilai) Dr. Nir Barzilai is the founding director of the Institute for Aging Research, the Nathan Shock Center of Excellence in the Basic Biology of Aging, and the Paul F. Glenn Center for the Biology of Human Aging Research at Albert Einstein College of Medicine of Yeshiva University. He is also the author of the book Age Later. Today, Dr. Nir brings his expertise to the podcast for a discussion regarding longevity and aging. Nir starts the conversation with a discussion on the existing regulatory frameworks that create impediments to the longevity biotech sector such as the FDA regulations. He also explores the use of metformin in combating age-related diseases, the clinical trials surrounding metformin being carried out in the Longevity Biotech Association, dealing with members of  the government, and his perspective regarding what longevity biotech will be like in 5 years. In this episode, you'll learn the uses of metformin and its relation to age-related diseases and what Nir hopes to see in the longevity industry in years to come . Episode Highlights: The existing regulatory frameworks that create impediments to the longevity biotech sector What is metformin and its relationship with age-related disease? Targeting aging with metformin — the TAME trial How other biomarkers would be tracked in the study The future of the trials and what is set to happen after it ends Examining the economics The mission of the Longevity Biotech Association The longevity industry in 5 years Challenges that come with conversing with the Government concerning longevity and aging Quotes: “Aging drives diseases and those diseases can be delayed.” “If aging drives all diseases, then it's the mother of diseases.” “After all, what are we trying to do? We are trying to prevent a cluster of age related diseases.” “Even if metformin doubles in price because of demand, it's still going to be the cheapest drug in the pharmacy.” “There are nine studies that show that people on metformin had less hospitalization, and less mortality from COVID if they were on metformin.” “Science is not a bipartisan issue.” “We need to extend the field and extend the actual funding to do it.” Links: Email questions, comments, and feedback to podcast@bioagelabs.com Translating Aging on Twitter:https://twitter.com/BioAgePodcast ( @bioagepodcast) BIOAGE Labs Websitehttps://bioagelabs.com/ ( BIOAGELabs.com) BIOAGE Labs Twitterhttps://twitter.com/bioagelabs?lang=en ( @bioagelabs) BIOAGE Labshttps://www.linkedin.com/company/bioage-labs/ ( LinkedIn) Dr. Nir Barzilai'shttps://twitter.com/NirBarzilaiMD ( Twitter)

Dr. Nir Barzilai is well-known in the field of longevity and beyond and is the director and chair of several institutes focused on Aging research. Just to name a few, he is the director of the Institute for Aging Research at the Albert Einstein College of Medicine and of the National Institutes of Health's (NIH) Nathan Shock Centers of Excellence in the Basic Biology of Aging. Dr. Barzilai's research interests are in the biology and genetics of aging, so he has done extensive work studying centenarians and supercentenarians some of which he discusses in today's episode and also in his book Age Later. He is currently leading an international effort to approve drugs that can target aging. Targeting Aging with METformin (TAME) is a specific study designed to prove the concept that multi-morbidities of aging can be delayed by metformin, working with the FDA to approve this approach which will serve as a template for future efforts to delay aging and its diseases in humans. In today's episode, we discuss centenarian longevity genes, what makes centenarians live so long and the role of growth hormones in longevity. We also dive into metformin's healthspan benefits for longevity, metformin & COVID, if metformin blunts muscle mass and causes hypoglycemia, and metformin dosage. Episode Show Notes + Timestamps: https://livelongerworld.substack.com/p/snbarzilai FOLLOW NIR BARZILAI: Profile: https://einsteinmed.edu/faculty/484/nir-barzilai/ Twitter: https://twitter.com/NirBarzilaiMD Book: https://us.macmillan.com/books/9781250230867 FOLLOW LIVE LONGER WORLD: Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/livelongerworld Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/longevityfuture/ Podcast All Platforms: https://anchor.fm/livelongerworld Patreon: https://www.patreon.com/livelongerworld YouTube: https://www.youtube.com/c/LiveLongerWorld Apple Podcasts: https://podcasts.apple.com/us/podcast/live-longer-world/id1588806541 Spotify: https://open.spotify.com/show/2Zc65BZb02msGuF9ujBThC

Dr. Nir Barzilai is the director of the Institute for Aging Research at the Albert Einstein College of Medicine and the Director of the Paul F. Glenn Center for the Biology of Human Aging Research and of the National Institutes of Health's (NIH) Nathan Shock Centers of Excellence in the Basic Biology of Aging. He is the Ingeborg and Ira Leon Rennert Chair of Aging Research, professor in the Departments of Medicine and Genetics, and member of the Diabetes Research Center and of the Divisions of Endocrinology & Diabetes and Geriatrics. Speakers: Nir Barzilai and Tim Peterson Hosts: Max Unfried and Morten Scheibye-Knudsen VitaDAO is the world's first decentralized intellectual property collective, funding and commissioning research into human longevity

Methuselah lived to 969 years old, according to the Bible. In our recent age, Jeanne Calmet holds the title of the oldest person who ever lived. She lived to be 122 years and 164 days old. There's a woman in Japan, Kane Tanaka, who is currently 118. Jiroemon Kimuri, also from Japan, is the oldest man of all time, living to 116 years and 54 days. How did they do it? How do some people avoid the deterioration and weakness that plagues many of their peers decades early? Is it luck, or something else? Is it possible to grow older without getting sicker? Could a 90-year-old not look a day over 50? In Age Later, Dr. Nir Barzilai, a pioneer in aging research, looked both at the four age-related diseases that take most of us (diabetes, cancer, heart disease, and Alzheimer's) and at SuperAgers (people who have maintained active lives well into their 90s who've never experienced any of those diseases). What can we learn from these subjects, who have not only reached a ripe old age but have further ripened the older they get? Dr. Barzilai revealed the secrets of these SuperAgers and the scientific discoveries so that we can mimic some of their natural resistance to the aging process. This isn't to say we'll live to 969, but there's still plenty of life yet to live for all of us. Dr. Nir Barzilai is the founding Director of the Institute for Aging Research at Albert Einstein College of Medicine, and is Director of the Nathan Shock Center for Excellence in the Basic Biology of Aging and the Einstein Glenn Center for the Biology of Human Aging. He is also the Scientific Director of the American Federation for Aging Research (AFAR). Lee Hood, MD, PhD is a world-renowned scientist who co-founded Seattle's Institute for Systems Biology (ISB) in 2000 and served as its first President from 2000-2017. When ISB affiliated with Providence in 2016, Dr. Hood became Providence's Senior Vice President and Chief Science Officer. He is also Chief Strategy Officer and Professor at ISB. Buy the Book: Age Later: Health Span, Life Span, and the New Science of Longevity (Hardcover) Third Place Books  Presented by Town Hall Seattle and Institute for Systems Biology. 

On this episode, Kennedy speaks with the Director of the Institute for Aging Research at the Albert Einstein College of Medicine and the author of the book Age Later Dr. Nir Barzilai.  Dr. Barzilai discusses the benefits of intermittent fasting on aging and long-term health and shares with Kennedy the many variations of intermittent fasting and determining which regiment is best fit for you. Later, Kennedy shares her experience with intermittent fasting vs. the keto diet. Follow Kennedy on Twitter: @kennedynation

Dr. Nir Barzilai, aging and longevity, author of "Age Later: Health Span, Life Span, and the New Science of Longevity", on Ashkenazic populations of extremely long lives

“We are here representing the field of the science of aging. And we think that this is a historical day for us, because we're going to offer something that will be paradigm changing.”Dr. Nir Barzilai is the director of the Institute for Aging Research at the Albert Einstein College of Medicine and the Director of the Paul F. Glenn Center for the Biology of Human Aging Research.In this episode, Dr. Nir Barzilai presents the current state of the groundbreaking TAME trial serving as a framework and data springboard for the whole longevity field, as well as the future plans for other TAME-like trials with other drugs with high potential for repurposing for aging. At the end, he also answers questions about the trial itself and why it is designed the way it is, but also some frequently asked questions about Metformin, like its effect on muscle building with exercise, the ideal dosing, and others.Music:Candlepower by Chris Zabriskie is licensed under a Creative Commons Attribution 4.0 license. https://creativecommons.org/licenses/by/4.0/Session summary: TAME Q&A: Lessons for Progress on Aging | Nir Barzilai, Albert Einstein School of Medicine - Foresight InstituteThe Foresight Institute is a research organization and non-profit that supports the beneficial development of high-impact technologies. Since our founding in 1987 on a vision of guiding powerful technologies, we have continued to evolve into a many-armed organization that focuses on several fields of science and technology that are too ambitious for legacy institutions to support.Allison Duettmann is the president and CEO of Foresight Institute. She directs the Intelligent Cooperation, Molecular Machines, Biotech & Health Extension, Neurotech, and Space Programs, Fellowships, Prizes, and Tech Trees, and shares this work with the public. She founded Existentialhope.com, co-edited Superintelligence: Coordination & Strategy, co-authored Gaming the Future, and co-initiated The Longevity Prize. Apply to Foresight's virtual salons and in person workshops here!We are entirely funded by your donations. If you enjoy what we do please consider donating through our donation page.Visit our website for more content, or join us here:TwitterFacebookLinkedInEvery word ever spoken on this podcast is now AI-searchable using Fathom.fm, a search engine for podcasts.  Hosted on Acast. See acast.com/privacy for more information.

Our second monthly Future of Longevity panel discussion featuring: George Church (Harvard Medical School) Nir Barzilai (Albert Einstein College of Medicine) Kristen Fortney (BioAge Labs) Jim Mellon (Juvenescence) Jay Olshansky (University of Illinois at Chicago) Alejandro Ocampo (University of Lausanne)

@michaelsalzle Exercising for longevity, feeding our longevity, preventing obesity, time restricted eating, using your DNA to your advantage, and bright horizons.

@michaelsalzle In this episode, we focus on the different hallmarks of aging as well as the TAME study, the study showing that meteformin can improve age related diseases such as CVD, diabetes, cancer, and dementia.

#nirbarzilai #humanlongevity #healthspan #agereversal #tame #metformin #livelong #livehealthier Dr. Nir Barzilai is the founding director of the Institute for Aging Research, the Nathan Shock Center of Excellence in the Basic Biology of Aging and the Paul F. Glenn Center for the Biology of Human Aging Research at Albert Einstein College of Medicine of Yeshiva University Dr Nir has studied over 600 centenarians to understand the biology and genetics of exceptional longevity. With this knowledge, Nir has spearheaded a randomized controlled trial of a medicine that interferes with the aging process to see if he can extend both the quantity and quality of life. TAME- is the worlds 1st FDA Approved anti-aging trial repurposing the drug #metformin & #rapamycin to control, stop & reverse aging. Dr Nir is also the author of the Book, Age Later: HealthSpan, Life Span, and the New Science of Longevity https://mstp.einstein.yu.edu/faculty/484/nir-barzilai/ https://www.cohbar.com/

Age Later: Health Span, Life Span, and the New Science of Longevity In Age Later Dr. Barzilai's New Book - https://amzn.to/30MOsGT Aging and Centenarian Studies : This is the part 2 of our interview series with Dr. Nir Brazilai from Albert Einstein College of Medicine. Dr. Barzilai is the founding director of the Institute for Aging Research at the Albert Einstein College of Medicine and the Director of the Paul F. Glenn Center for the Biology of Human Aging Research and of the National Institutes of Health's (NIH) Nathan Shock Centers of Excellence in the Basic Biology of Aging. Dr. Barzilai discovered the first longevity gene in humans and has since discovered several others. In addition to his “longevity gene” research, Dr. Barzilai studies key mechanisms involved in the biology of aging, including how nutrients and genetics influence lifespan. He is also investigating the physical and mental declines associated with aging and how they affect longevity. He is the author of over 270 peer-reviewed papers and a recipient of numerous prestigious awards,including the recipient of the 2010 Irving S. Wright Award of Distinction in Aging Research and is the 2018 recipient of the IPSEN Longevity award. Dr. Barzilai's New Book - Age Later: Health Span, Life Span, and the New Science of Longevity In Age Later, the No.1 Best Sellers in Physiology section in Amazon, reveals the secrets his team has unlocked about SuperAgers and the scientific discoveries that show we can mimic some of their natural resistance to the aging process. In this interview Dr. Barzilai discusses his Metformin, rapamycin and the TAME trial, a large scale clinical trial of Metformin to see if it can reduce or delay the effects of aging. Health claims Disclosure: Information provided on this video is not a substitute for direct, individual medical treatment or advice. It is the responsibility of you and your healthcare providers to make all decisions regarding your health. Products or services mentioned in this video are not a recommendation. Disclosure: Some of the links provided are affiliate links. Although we may receive a small commission from the affiliate, the cost of the product for you will always be the same, or often discounted. Thank you for supporting our channel!

In this episode, Daniel Belkin and Mitch Belkin interview Dr. Nir Barzilai, the founding director of the Institute for Aging Research and an expert in the genetics of longevity. Nir Barzilai is a professor in the departments of Medicine and Genetics at the Albert Einstein College of Medicine. He is the recipient of numerous awards and grants. He has published over 230 peer-reviewed papers, reviews, and textbook chapters, as well as the book Age Later. In this interview, we discuss the field of gero-therapeutics, the hallmarks of aging, and gender differences in aging. We review his work on centenarians and what they can teach us about the genetics of longevity. Finally, we delve into metformin, its use as an anti-aging therapy, its mechanism of action and the TAME trial, on which he is the primary investigator. To learn more about the latest in aging-related research, check out the American Federation of Aging.   This interview was recorded on March 26, 2021. Centenarian studies:The Longevity Genes Project is geared at understanding which genetic factors contribute to exceptionally long life. The project focuses on Ashkenazi “super agers”–people between the ages of 95 and 112–to determine how their genetics differ from controls without exceptional longevity. In addition, the study follows the children of “super agers” with matched controls.What is Metformin?Metformin (Glucophage) is a biguanide that is a first-line treatment for type 2 diabetes. While it has many mechanisms of action, its primary mechanisms of action are believed to be (1)  decreasing hepatic glucose production by inhibiting gluconeogenesis, (2) inhibiting complex I of the electron transport chain, and (3) inhibiting the mammalian target of rapamycin (mTOR) signaling pathway. It is the 4th most prescribed medication in the United States. Metformin use is associated with a reduction in the incidence of cancer. It is also associated with reductions in cognitive decline and Alzheimer's among diabetics. If you are interested in learning more about how metformin attenuates the hallmarks of aging, Nir Barzilai wrote a paper in cell metabolism: Benefits of Metformin in Attenuating the Hallmarks of Aging (2020).What is the TAME Trial?The Targeting Aging with Metformin (TAME) Trial is a placebo-controlled clinical trial designed to determine whether taking metformin delays the development or progression of age-related chronic diseases, including heart disease, cancer, and dementia. The study population will include 3,000 individuals at 14 sites across the U.S. who are between the ages of 65-79. Patients will receive either 1500mg Metformin daily or a placebo for up to 6 years.

@michaelsalzle. Cholesterol, GH, and our mitochondria.

Age Later: Health Span, Life Span, and the New Science of Longevity In Age Later Dr. Barzilai's New Book - https://amzn.to/30MOsGT Aging and Centenarian Studies : This is the part 3 of our interview series with Dr. Nir Brazilai from Albert Einstein College of Medicine. Dr. Barzilai is the founding director of the Institute for Aging Research at the Albert Einstein College of Medicine and the Director of the Paul F. Glenn Center for the Biology of Human Aging Research and of the National Institutes of Health's (NIH) Nathan Shock Centers of Excellence in the Basic Biology of Aging. Dr. Barzilai discovered the first longevity gene in humans and has since discovered several others. In addition to his “longevity gene” research, Dr. Barzilai studies key mechanisms involved in the biology of aging, including how nutrients and genetics influence lifespan. He is also investigating the physical and mental declines associated with aging and how they affect longevity. He is the author of over 270 peer-reviewed papers and a recipient of numerous prestigious awards,including the recipient of the 2010 Irving S. Wright Award of Distinction in Aging Research and is the 2018 recipient of the IPSEN Longevity award. Dr. Barzilai's New Book - Age Later: Health Span, Life Span, and the New Science of Longevity In Age Later, the No.1 Best Sellers in Physiology section in Amazon, reveals the secrets his team has unlocked about SuperAgers and the scientific discoveries that show we can mimic some of their natural resistance to the aging process. In this video Dr. Barzilai draws on his long experience working in the aging field to talk about some of the ways that we can improve our healthspan. His data provides some, perhaps, surprising advice on the ideal BMI and exercise with metformin. Health claims Disclosure: Information provided on this video is not a substitute for direct, individual medical treatment or advice. It is the responsibility of you and your healthcare providers to make all decisions regarding your health. Products or services mentioned in this video are not a recommendation. Disclosure: Some of the links provided are affiliate links. Although we may receive a small commission from the affiliate, the cost of the product for you will always be the same, or often discounted. Thank you for supporting our channel!

Age Later: Health Span, Life Span, and the New Science of Longevity In Age Later Dr. Barzilai's New Book - https://amzn.to/30MOsGT Aging and Centenarian Studies : This is the part 1 of our interview series with Dr. Nir Brazilai from Albert Einstein College of Medicine. Dr. Barzilai is the founding director of the Institute for Aging Research at the Albert Einstein College of Medicine and the Director of the Paul F. Glenn Center for the Biology of Human Aging Research and of the National Institutes of Health's (NIH) Nathan Shock Centers of Excellence in the Basic Biology of Aging. Dr. Barzilai discovered the first longevity gene in humans and has since discovered several others. In addition to his “longevity gene” research, Dr. Barzilai studies key mechanisms involved in the biology of aging, including how nutrients and genetics influence lifespan. He is also investigating the physical and mental declines associated with aging and how they affect longevity. He is the author of over 270 peer-reviewed papers and a recipient of numerous prestigious awards,including the recipient of the 2010 Irving S. Wright Award of Distinction in Aging Research and is the 2018 recipient of the IPSEN Longevity award. Dr. Barzilai's New Book - Age Later: Health Span, Life Span, and the New Science of Longevity In Age Later, the No.1 Best Sellers in Physiology section in Amazon, reveals the secrets his team has unlocked about SuperAgers and the scientific discoveries that show we can mimic some of their natural resistance to the aging process. In this interview Dr. Barzilai discusses his study of centenarians, what he learnt from that and how it can be applied. By studying centenarians and the mechanisms that keep them healthy he hopes to short cut years research and animal trials. Health claims Disclosure: Information provided on this video is not a substitute for direct, individual medical treatment or advice. It is the responsibility of you and your healthcare providers to make all decisions regarding your health. Products or services mentioned in this video are not a recommendation. Disclosure: Some of the links provided are affiliate links. Although we may receive a small commission from the affiliate, the cost of the product for you will always be the same, or often discounted. Thank you for supporting our channel!

@michaelsalzle. The mysteries of aging, what makes superagers stay healthy, a perfect genome, centenarians interactions with their environment, good genes, why we age, theories of aging, and how caloric restriction leads to longevity

TAME (Targeting Aging with Metformin) aims to slow the aging process. It has been developed and approved by the National Institute of Aging and the FDA. The principal investigator, Nir Barzilai, is excited about changing the paradigm and getting big PHARMA to actually fund research for drugs (like metformin) for anti-aging.  Getting older is associated with heart disease, kidney disease, cancer, dementia, among other things. This is where metformin comes in. It helps slow down the major biochemical challenge of aging: glucose metabolism. Enzymes like insulin membrane receptors, mTOR, AMPK, and SIRT1 are implicated. And they are positively impacted by metformin.  Metformin is cheap (free at many pharmacies now). It's been used for decades. It's popular (the #1 oral drug for early type 2 diabetes). And it's safer than you think.  Some medical sites (like Mayo) still incorrectly list lactic acidosis as a problem with metformin. But look up the multiple Cochrane analyses on this. For more information, contact us at 859-721-1414 or myhealth@prevmedheartrisk.com. Also, check out the following resources: PrevMed's article on metforminPrevMed's websitePrevMed's YouTube channelPrevMed's Facebook page

The concept of healthspan - the number of years that we enjoy optimum health - has come a long way, in recent years. In fact, Dr. Nir Barzilai, founding director of the Institute for Aging Research at Albert Einstein College of Medicine, believes we are "ushering in a future where the norm will be for people to be healthy, active and mentally sharp, during the last quarter of their lives." In his new book, Age Later: Healthspan, Life Span, and the New Science of Longevity, he argues that aging can be "targeted, improved and even cured," and that it should be thought of as not "as a certainty but as a phenomenon." In this LLAMA podcast episode, with Peter Bowes, Dr Barzilai, discusses his life's work studying some of the world's super agers, people who are enjoying active and productive lives well into their nineties and beyond. Recorded: September 21st, 2020 | Read a transcript and show notes at the LLAMA podcast website.Topics covered in this interview include:Dr Barzilai's lifelong interest in longevity and healthspanThe impact of Covid 19 and why it has highlighted issues surrounding agism. Post-covid and finding the right balance with social interactions. The TAME (Targeting Aging with Metformin) study and wider uses for the anti-diabetic drug, relating to aging, coronavirus and cancer. Should we all be taking metformin? The ethical dilemmas. Why "flexible" biology of aging. What has been learned through the study of 750 centenarians?Learning lessons from Frieda - the grandmother of Dr. Barzilai's wife. Why we should not put off our dreams. The longevity dividend.Caloric restriction, fasting and time-restricted eating.Getting enough sleep.Earlier LLAMA podcast in with Dr. Barzilai: Researching the genetics of exceptional longevity and drugs that could target agingThe Live Long and Master Aging podcast shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

Kathryn interviews Scientific Director of the American Federation for Aging Research Nir Barzilai MD, author of “Age Later: Health Span, Life Span, and the New Science of Longevity.” He outlines how a combination of lifestyle changes and medication may help older people become less susceptible to illnesses like COVID by increasing not only their immunity but also the overall ability for their body to be able to survive a serious illness. Kathryn also interviews Journalist Reid Forgrave, author of “Love, Zac: Small-Town Football and the Life and Death of an American Boy.” He explores Zac's tight-knit, football-obsessed Midwestern community; he interviews leading brain scientists, psychologists and sports historians; and he takes a deep dive into the triumphs and sins of the sports entertainment industry. Forgrave has covered the NFL and college football for FoxSports.com and CBS Sports and has been featured in GQ, the NY Times Magazine and Mother Jones.

Kathryn interviews Scientific Director of the American Federation for Aging Research Nir Barzilai MD, author of “Age Later: Health Span, Life Span, and the New Science of Longevity.” He outlines how a combination of lifestyle changes and medication may help older people become less susceptible to illnesses like COVID by increasing not only their immunity but also the overall ability for their body to be able to survive a serious illness. Kathryn also interviews Journalist Reid Forgrave, author of “Love, Zac: Small-Town Football and the Life and Death of an American Boy.” He explores Zac's tight-knit, football-obsessed Midwestern community; he interviews leading brain scientists, psychologists and sports historians; and he takes a deep dive into the triumphs and sins of the sports entertainment industry. Forgrave has covered the NFL and college football for FoxSports.com and CBS Sports and has been featured in GQ, the NY Times Magazine and Mother Jones.

“Ageing is, simply and clearly, the accumulation of damage in the body. That’s all that ageing is.–Aubrey de Grey It’s that simple. Or so say Aubrey de Grey and his many followers in the gerontological and biotech communities. But the sixty-four dollar question is: how does the message disseminate to the rest of the world? […]

Dr. Nir Barzilai is working to find the genes that cause us to age faster and slower. He's put what we know in his new book, Age Later: Healthspan, Life Span, and the New Science of Longevity. You can find the full show notes at 40plusfitnesspodcast.com/449.  

Podcast Notes Key Takeaways When taking rapalog, innate immune function is augmented possibly driving enhanced adaptive immune system when vaccinatedStudies have shown that people on metformin who were diabetic and obese still had significantly less mortality than otherwise metabolically healthy individualsRapalogs and metformin both address a critical piece of fighting a virus: reducing comorbidities  There’s some evidence that a direct antiviral effect between mTor inhibition and SARS-CoV-2 exists“We’re not fighting the virus, we’re reinforcing the host.” – Nir BarzilaiRead the full notes @ podcastnotes.orgIn this episode, Joan and Nir discuss their extensive research into rapamycin (including the category of analogs to rapamycin known as rapalogs) and metformin, respectively. Based on his work with metformin, Nir shares how he believes it could be a pro-longevity drug and the clinical trial he’s leading to test this belief. Joan discusses her work with rapalogs, their ability to suppress the immune system as well as provide immune-enhancement, and the clinical trials she has led that inform her insights. We also talk about the potential beneficial roles of both metformin and rapamycin in reducing mortality from COVID-19, reducing the risk of neurodegenerative diseases, and delaying aging as well as its related diseases.    We discuss: Joan’s career, interest in aging, and work with rapamycin analogs [3:45]; When Nir became convinced metformin could be a pro-longevity agent [15:00]; How metformin and rapamycin impact the hallmarks of aging and extend lifespan [24:15]; Enhancing the immune system with rapalogs and metformin [34:15]; Potential of metformin and rapamycin in reducing mortality from COVID-19 [41:30]; Insights from Joan’s studies investigating the immune-enhancing effects of rapalogs [59:30]; Vaccines and treatments strategies for COVID-19, and the likelihood of long-term immunity [1:08:15]; The potential role of rapalogs and metformin in neurodegenerative disease [1:14:30]; Nir’s TAME trial—primary objectives and latest updates [1:18:00]; Potential synergistic effect when combining metformin with rapamycin [1:25:45]; Why Peter stopped taking metformin and started taking rapamycin [1:27:30]; Story from Nir’s book that demonstrates the challenge of doing good scientific studies [1:37:30]; The biology of aging—epigenetic clocks, proteomics, and Nir’s centenarian data [1:42:00]; Joan’s dream experiment to test immune-enhancing effect of RTB101 [1:57:15]; Concluding thoughts on COVID-19 [1:59:45]; and More. Learn more: https://peterattiamd.com/ Show notes page for this episode: http://peterattiamd.com/joanmannick-nirbarzilai/ Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.

The founder of the Institute for Aging Research at the Albert Einstein College of Medicine, Nir Barzilai is one of the leading pioneers of longevity research and a proponent of regarding aging as a treatable disease, just like any other disease. Nir has a new book Age Later: Health Span, Life Span and the New Science of Longevity. He is a strong advocate for using Metformin and intermittent fasting as proven methods of extending health span and life span. The future of aging will be to erase it at a cellular level. We discuss how COVID has brought all this into focus and what the heck the COVID toe is that I had. Let's get into some science.

In this episode, Joan and Nir discuss their extensive research into rapamycin (including the category of analogs to rapamycin known as rapalogs) and metformin, respectively. Based on his work with metformin, Nir shares how he believes it could be a pro-longevity drug and the clinical trial he’s leading to test this belief. Joan discusses her work with rapalogs, their ability to suppress the immune system as well as provide immune-enhancement, and the clinical trials she has led that inform her insights. We also talk about the potential beneficial roles of both metformin and rapamycin in reducing mortality from COVID-19, reducing the risk of neurodegenerative diseases, and delaying aging as well as its related diseases.    We discuss: Joan’s career, interest in aging, and work with rapamycin analogs [3:45]; When Nir became convinced metformin could be a pro-longevity agent [15:00]; How metformin and rapamycin impact the hallmarks of aging and extend lifespan [24:15]; Enhancing the immune system with rapalogs and metformin [34:15]; Potential of metformin and rapamycin in reducing mortality from COVID-19 [41:30]; Insights from Joan’s studies investigating the immune-enhancing effects of rapalogs [59:30]; Vaccines and treatments strategies for COVID-19, and the likelihood of long-term immunity [1:08:15]; The potential role of rapalogs and metformin in neurodegenerative disease [1:14:30]; Nir’s TAME trial—primary objectives and latest updates [1:18:00]; Potential synergistic effect when combining metformin with rapamycin [1:25:45]; Why Peter stopped taking metformin and started taking rapamycin [1:27:30]; Story from Nir’s book that demonstrates the challenge of doing good scientific studies [1:37:30]; The biology of aging—epigenetic clocks, proteomics, and Nir’s centenarian data [1:42:00]; Joan’s dream experiment to test immune-enhancing effect of RTB101 [1:57:15]; Concluding thoughts on COVID-19 [1:59:45]; and More. Learn more: https://peterattiamd.com/ Show notes page for this episode: http://peterattiamd.com/joanmannick-nirbarzilai/ Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.

This week, Micky & Quinn sit down with Dr. Nir Barzilai of Albert Einstein College of Medicine. The author of Age Later, Dr. Barzilai is a physician and gerontology researcher who has made important contributions to the molecular and behavioral understanding of the aging process in humans. The discussion examines not only the biology of aging, but also the future of medicine, how to stay healthier later in life, and how tomorrow's humans might become better incentivized to take care of one another. Support us & Dr. Barzilai when you buy his book: Age Later: https://amzn.to/30lguJs More readings from us: https://demystifyingscience.com Let's talk! @DemystifySci Twitter: https://twitter.com/demystifysci Instagram: https://www.instagram.com/demystifysci Facebook: https://www.facebook.com/demystifysci Music by Our own Shilo Delay: https://soundcloud.com/laterisgone --- Support this podcast: https://anchor.fm/demystifying-science/support

Connecticut Today with Paul Pacelli opened the week with a great interview with Dr. Nir Barzilai, founding director of the Institute for Aging Research, the Nathan Shock Center of Excellence in the Basic Biology of Aging and the Paul F. Glenn Center for the Biology of Human Aging Research at Albert Einstein College of Medicine of Yeshiva University. He spoke to Paul about things that even older people can do in terms of activity and nutrition that can help fight the Coronavirus. Also we carried part of Governor Ned Lamont's meeting with the media.

Attorney-CPA Joe Cordell and co-host Jill Enders are joined by Dr. Nir Barzilai, author, aging expert, founder of the Institute for Aging Research at the Albert Einstein College of Medicine, and Scientific Director of the American Federation for Aging. They discuss what steps seniors can take to protect themselves from exposure to COVID-19, while combating […] The post Targeting Aging With Dr. Nir Barzilai [Episode 156] appeared first on Joseph E. Cordell.

We get the Businessweek Agenda with Bloomberg News International Economics & Policy Correspondent Michael McKee and Jeffrey Cleveland, Chief Economist at Payden & Rygel. Bloomberg Businessweek Editor Joel Weber and Bloomberg Businessweek Writer Claire Suddath talk about a case of empty frames remaining the art world’s biggest mystery. Dr. Nir Barzilai, Founder of the Institute for Aging Research at the Albert Einstein College of Medicine, discusses protecting those most vulnerable to COVID-19. We get the Businessweek Small Business Survival Guide with Bloomberg News Editor Dimitra Kessenides and Abigail Chapin, Owner of Abigail Rose & Lily, Too. They walk through reopening in NYC. And we Drive to the Close with Hilary Kramer, President and CIO at A&G Capital. Hosts: Carol Massar and Jason Kelly. Producer: Doni Holloway. 

We get the Businessweek Agenda with Bloomberg News International Economics & Policy Correspondent Michael McKee and Jeffrey Cleveland, Chief Economist at Payden & Rygel. Bloomberg Businessweek Editor Joel Weber and Bloomberg Businessweek Writer Claire Suddath talk about a case of empty frames remaining the art world's biggest mystery. Dr. Nir Barzilai, Founder of the Institute for Aging Research at the Albert Einstein College of Medicine, discusses protecting those most vulnerable to COVID-19. We get the Businessweek Small Business Survival Guide with Bloomberg News Editor Dimitra Kessenides and Abigail Chapin, Owner of Abigail Rose & Lily, Too. They walk through reopening in NYC. And we Drive to the Close with Hilary Kramer, President and CIO at A&G Capital. Hosts: Carol Massar and Jason Kelly. Producer: Doni Holloway.  Learn more about your ad-choices at https://www.iheartpodcastnetwork.com

Aging expert Dr. Nir Barzilai, author of “Age Later: Health Span, Life Span, and the New Science of Longevity,” joins host Ryan Wrecker to explain the evolution of health and recommendations to slow down aging. Next, Attorney and KMOX Personality Brad Young shares his knowledge and expertise on the businesses that are now suing city government over tolerance of the occupied protest zone in Seattle.

Nir Barzilai shares his expertise on how ageing can be targeted and reversed. Dr Barzilai is a chaired Professor of Medicine and Genetics and Director of the biggest Centre in the world to study the Biology of Ageing, Institute for Aging at The Albert Einstein College of Medicine.

Incredible new breakthroughs in research reveal that we can slow down, or even reverse aging. Newt’s guests are Dr. David Sinclair, author of Lifespan: Why We Age – and Why We Don’t Have To and Dr. Nir Barzilai from National Institutes of Health.

Dr. Nir Barzilai discusses his clinical studies with centenarians and their families. How do sleep, diet, exercise, medication, childbirth, and more affect aging? How can we live longer? Norma will find out!

Maybe you've heard drinking coffee will keep you alive longer, that antioxidants will slow down the aging process, or that jogging will add 10 years to your life. But is there really a secret to living longer? Whatever the secret is, we're talking about the latest research with Dr. Nir Barzilai. He joins us to discuss his research on human lifespan and longevity, and to take your calls about the mysteries of aging! This episode is sponsored by The Great Courses Plus (www.thegreatcoursesplus.com/SCIENCERULES), MagellanTV (www.magellantv.com/sciencerules), and KiwiCo (www.kiwico.com/SCIENCERULES).

In this episode, Nir Barzilai, director of the Institute for Aging Research and expert in the genetics of longevity, discusses the evidence that metformin and rapamycin have anti-aging properties and how his TAME study aims to support this hypothesis in humans. Additionally, he describes the role of genetics in lifespan/healthspan and how it might affect important pathways such as IGF and insulin sensitivity. We discuss: Nir’s background and interest in aging and endocrinology [3:30]; History of metformin, and understanding the mechanism [11:15]; Attempting to define insulin resistance [21:15]; Metformin as a possible anti-aging drug [48:45]; The TAME trial: Targeting Aging with MEtformin [57:45]; Why Nir believes metformin can slow aging [1:16:30]; The genetic gift of centenarians [1:28:00]; IGF/GH and its impact on aging and chronic diseases [1:34:15]; Genetics/epigenetics of centenarians, gene sequencing, CETP-VV, Lp(a) [1:49:15]; Should you be taking HGH? [2:05:30]; NAD and NAD precursors (NR and NMN) [2:30:00]; Parting thoughts on metformin [2:36:15]; Possible blind spots in Nir and Peter’s thinking? [2:43:00]; and More. Learn more at www.PeterAttiaMD.com Connect with Peter on Facebook | Twitter | Instagram.

Nir Barzilai is a professor of medicine and genetics at the Albert Einstein College of Medicine and the director of the Institute for Aging Research. He is best known for his work with some of the world’s oldest populations and is currently leading an international effort to aprove drugs that could target aging. Dr. Barzilai was born in Isreal and has had a life-long interest in the mechanisms that control the aging process. He hypothesizes that centenarians have protective genes which delay aging or protect against age-related diseases.

August 3, 2011 - New research from scientists at Albert Einstein College of Medicine of Yeshiva University suggests that centenarians' lifestyle choices have little to no impact on their extreme longevity and healthy aging. The study was published in the August 3 online edition of the Journal of the American Geriatrics Society.

May 24, 2012 – Researchers at Albert Einstein College of Medicine and Ferkauf Graduate School of Psychology of Yeshiva University have found that personality traits like being extroverted, enjoying laughter and staying engaged may also be part of the longevity genes mix that allows some people to reach age 100 and beyond. The findings published online May 21 in the journal Aging.

Nir Barzilai, M.D., Principal Investigator The Longevity Genes Project at Einstein is a study of more than 500 healthy centenarians, near-centenarians and their children. In this video, principal investigator Dr. Nir Barzilai, director of the Institute for Aging Research and director of the Nathan Shock Center of Excellence in the Basic Biology of Aging, discusses the findings to date. Dr. Barzilai also explains his personal and professional quest for ways to significantly delay age-related diseases such as Alzheimer’s disease and to help people live longer, healthier lives. To watch all of the videos in the series, please visit www.superagers.com.

The Longevity Genes Project at Einstein is a study of more than 500 healthy centenarians, near-centenarians and their children. Learn more about this exciting research project whose aim is to unlock the genetic keys to healthier, longer life. Dr. Nir Barzilai, who leads the project, explains his quest to significantly delay age-related diseases such as Alzheimer’s disease and cardiovascular disease. You’ll also meet four centenarians or near-centenarians whose stories will inspire you. To watch all of the videos in the series, please visit www.superagers.com. (Trailer runs 1:37)

July 22, 2009 — A cellular protein that may prevent nerve cells from dying also helps to improve insulin action and lower blood glucose levels, according to a study by researchers at Albert Einstein College of Medicine of Yeshiva University in collaboration with scientists at University of California, Los Angeles (UCLA).

Guest: Nir Barzilai, MD Host: Maurice Pickard, MD What does the latest research tell us about longevity? Dr. Nir Barzilai, director of the Institute for Aging Research at the Albert Einstein College of Medicine and chaired professor of medicine and molecular genetics, discusses the development of a study in a homogenous founder population in order to identify the biological and genetic underpinnings of exceptional longevity. The genotype and associated phenotype may modulate aging processes and disease susceptibility. Hosted by Dr. Maurice Pickard.

Guest: Nir Barzilai, MD Host: Maurice Pickard, MD What is the role of insulin growth factor in longevity? Dr. Nir Barzilai, director of the Institute for Aging Research at the Albert Einstein College of Medicine and chaired professor of medicine and molecular genetics, speaks about changes in insulin-like growth factor pathways in relation to longevity. The genotype of exceptional age is also associated with improved cognitive function.

Audio Journal of Global Health Issues reporting from American College of Physicians Annual Meeting: Internal Medicine 2007; San Diego April 19-21 Study on Longevity Genes And Aging Raises Prospects for Therapy REFERENCE: ABSTRACT ERA 001 ACP 2007, San Diego NIR BARZILAI, Albert Einstein College of Medicine, New York The prospect of modulating the activity of "longevity genes" to extend life was held out at a special session of the ACP Internal Medicine annual meeting in San Diego. Nir Barzilai, Director of the Institute for Aging Research in New York, presented data from his group's study of patients up to 100 years old and over which have shown that specific genes are related to longevity and freedom from physical illness. Afterwards he talked about his findings and the clinical opportunities they present with Peter Goodwin.