Podcasts about rapamycin

Pharmaceutical drug

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Best podcasts about rapamycin

Latest podcast episodes about rapamycin

The Body Reimage Podcast
Die Young at a Very Old Age. Anti-aging strategies!

The Body Reimage Podcast

Play Episode Listen Later Sep 25, 2022 45:11


Is it possible to stay young, youthful and energetic as we age? Recent medical research is shedding light on what makes some people get old as they age while others seem to get younger. Listen in on this discussion to learn the anti aging strategies that can slow or even reverse your age at a cellulare level (not just botox for looks, but a body that is actually young!) what lifestyle changes you must do which supplements are safe and effective what prescription medications are available right now that  Personal trainer Jesse Frank and Weight Loss Dr. Charlie Seltzer discuss all topics on Nutrition, Fitness, Weight Loss, Bodybuilding, Training and more. Separating fact from fiction using evidence based research and real world experience, Jesse and Charlie answer your questions on how to best apply the most effective strategies for long term success.   https://www.drseltzerweightloss.com https://www.lvrgfit.com https://www.instagram.com/drseltzerweightloss/ https://www.instagram.com/lvrgfit/

SuperAge: Live Better
What Is Rapamycin & Why Are People Taking It?: Ross Pelton

SuperAge: Live Better

Play Episode Listen Later Sep 22, 2022 50:21


What is rapamycin? What is mTor? What is the connection between rapamycin and cancer? How does rapamycin activate autophagy? Who should and shouldn't take rapamycin? What are the benefits and risks of intermittent fasting? Thank you to our sponsor, LMNT. Listeners receive a free 8-serving sample pack with their purchase here. Thank you to our sponsor, InsideTracker. Listeners get 20% off on all products here. Ross Pelton, pharmacist and scientific director for Essential Formulas, Inc joins us to discuss rapamycin and its potential benefit for age-related diseases, its connection to cancer treatment, intermittent fasting, and more. Disclaimer: This is not medical advice. Always consult your doctor before adding any supplements or medications into your life. “Rapamycin is the most effective anti-aging drug that's ever been discovered.” “These days, people start eating at 7 in the morning and do breakfast, lunch and dinner and mid-meal snacks and dessert after supper and maybe an evening cocktail. So, from 7 in the morning until 7 at night, that's 12 hours, another 4 hours to finish digesting food, that's 16 hours. Whereas ancestral humans only had 4 hours of eating and digesting a day.” “You can't be in a go, go, go position all the time or you will burn yourself out.”“In animal studies, virtually every single type of age-related disease improves when the animals take rapamycin.” Listen to the SuperAge podcast wherever you get your pods. Connect with Ross Pelton:WebsiteBookArticles (1, 2, 3)

Health Quest Podcast with Steve Lankford
421 – Rapamycin: Extending Health Span and Lifespan

Health Quest Podcast with Steve Lankford

Play Episode Listen Later Sep 13, 2022 50:15


In this interview Ross Pelton discusses Rapamycin and autophagy. These were new terms for me. The story of Rapamycin is interesting and intriguing. Rapamycin is a drug that was developed after discovery on Easter Island led to the drug's development. This is an example of how a natural compound in nature is discovered, researched and developed as a drug. Ross covers this discovery in this interview and in his newest book: RAPAMYCIN – The Most Promising Life Extension Drug. This was all new to me and Ross' book is a powerful introduction. “Autophagy (pronounced “ah-TAH-fah-gee”) is your body's process of reusing old and damaged cell parts. Cells are the basic building blocks of every tissue and organ in your body. Each cell contains multiple parts that keep it functioning. Over time, these parts can become defective or stop working. They become litter, or junk, inside an otherwise healthy cell. Autophagy is your body's cellular recycling system. It allows a cell to disassemble its junk parts and repurpose the salvageable bits and pieces into new, usable cell parts. A cell can discard the parts it doesn't need. Autophagy is also quality control for your cells. Too many junk components in a cell take up space and can slow or prevent a cell from functioning correctly. Autophagy remakes the clutter into the selected cell components you need, optimizing your cells' performance.” Source: ClevelandClinic.org The post 421 – Rapamycin: Extending Health Span and Lifespan appeared first on Health Quest Podcast.

Nutrition Without Compromise
Rapamycin: The Key To Extending Your Healthspan and Lifespan With The Natural Pharmacist, Ross Pelton

Nutrition Without Compromise

Play Episode Listen Later Sep 12, 2022 44:16


What if there was a compound that helped you not just extend your lifespan but do it healthily as well? That compound is Rapamycin. Today's guest is an expert on the topic and has even authored a book entitled Rapamycin, mTOR, Autophagy & Treating mTOR Syndrome. Ross Pelton, aka The Natural Pharmacist, is a certified clinical nutritionist. He was named one of the top 50 most influential pharmacists in America by American Druggist Magazine for his work in natural medicine in 1999. In this episode, he joins Corinna Bellizzi to discuss the multiple health benefits of Rapamycin and how it facilitates mTOR and autophagy. Listen to their educational and informative chat to learn which simple lifestyle and nutrition habits can affect your body's anti-aging capacity. Key takeaways from this episode:- The meaning of mTOR- How Rapamycin works in the body- How the body benefits from autophagy- How intermittent fasting helps autophagy- Rapamycin optimizes the body against multiple diseases in animal models- How Rapamycin contributes to anti-aging and living a longer healthier life Guest Social Links:LinkedIn: https://www.linkedin.com/in/naturalpharmacist/ Book: https://www.lifeextension.com/rapa

The Common Sense MD
Rapamycin

The Common Sense MD

Play Episode Listen Later Sep 6, 2022 13:21


In this episode of The Common Sense MD, Dr. Rogers does a deep dive on Rapamycin and how it can be an effective tool for longevity. Hope this episode of the podcast brings you a ton of value! What did you think of this episode of the podcast? Let us know by leaving a review! Connect with Performance Medicine! Sign up for our weekly newsletter: https://performancemedicine.net/doctors-note-sign-up/ Facebook: @PMedicine Instagram: @PerformancemedicineTN YouTube: Performance Medicine

Know Your Physio
Cardiovascular Disease, Statins, Metformin, and Rapamycin with Kevin Bass

Know Your Physio

Play Episode Listen Later Aug 29, 2022 35:37


Despite what we want to believe, cardiovascular disease does not only start once we are in our 50s and 60s. As we welcome Kevin Bass back to the Know Your Physio podcast, we hear his opinions on cholesterol, the medications to take, and opinions on collected long-term genetic studies. We don't hold back on having a controversial conversation around starting the reduction of low-density lipoprotein (LDL) cholesterol in your mid to late 20s, the role of genetics in our predisposition to cardiovascular health issues, and how we need to look at things from an environmental, health, and nutrition perspective. Kevin tells us about his preferences and opinions on the different interventions for LDL cholesterol reduction and how he aims to (one day in the future) create a risk reduction calculator that will look at and create a risk-benefit profile. Plus, Kevin discusses his feelings toward Andrew Huberman, consulting medical professionals, and some signs of when it may be time to start looking at taking prescription cholesterol medication!Key Points From This Episode:People in the fitness industry who are pissing Kevin off.Different calculations people can do to determine their risk of cardiovascular disease.Interventions for LDL cholesterol (including prescription medication) and their side effects. A look at how to reduce LDL cholesterol.Kevin's opinions on Andrew Huberman.Unpacking cardiovascular disease considering your genetics and potential preventative measures. Why Kevin believes people 25 and older can start cholesterol medication.Where Kevin gets the long-term genetic studies data from.Analyzing and interpreting data on cardiovascular disease to create a relative risk reduction.Why Kevin wants to create his own risk reduction calculator and risk-benefit profile.Signs people should start looking for when deciding to take cholesterol medication.Questions to potentially ask your doctor to help you identify your cardiovascular risk (and why they may be unlikely to prescribe).A look at the purpose and benefits of statins, metformin, and rapamycin.Links Mentioned in Today's Episode:The Diet WarsKevin Bass on TwitterThe Kevin Bass Show YouTubeDebunking Andrew HubermanBiOptimizersAndrés PreschelKnow Your Physio PodcastSupport the show

The Tim Ferriss Show
#617: In Case You Missed It: July 2022 Recap of "The Tim Ferriss Show"

The Tim Ferriss Show

Play Episode Listen Later Aug 27, 2022 60:10 Very Popular


Welcome to another episode of The Tim Ferriss Show, where it is my job to deconstruct world-class performers to tease out the routines, habits, et cetera that you can apply to your own life. This is a special inbetweenisode, which serves as a recap of the episodes from last month. It features a short clip from each conversation in one place so you can easily jump around to get a feel for the episode and guest.Based on your feedback, this format has been tweaked and improved since the first recap episode. For instance, @hypersundays on Twitter suggested that the bios for each guest can slow the momentum, so we moved all the bios to the end. See it as a teaser. Something to whet your appetite. If you like what you hear, you can of course find the full episodes at tim.blog/podcast. Please enjoy! ***This episode is brought to you by 5-Bullet Friday, my very own email newsletter that every Friday features five bullet points highlighting cool things I've found that week, including apps, books, documentaries, gadgets, albums, articles, TV shows, new hacks or tricks, and—of course—all sorts of weird stuff I've dug up from around the world.It's free, it's always going to be free, and you can subscribe now at tim.blog/friday.***Full episode titles:Liv Boeree, Poker and Life — Core Strategies, Turning $500 into $1.7M, Cage Dancing, Game Theory, and Metaphysical Curiosities (#611)Luis von Ahn, Co-Founder and CEO of Duolingo — How to Be (Truly) Mission-Driven, Monetization Experiments, 10x Growth, Org Chart Iterations for Impacting Metrics, The Intricate Path to an IPO, Best Hiring Practices, Catching Exam Cheaters, The Allure of Toto Toilets, The Future of Duolingo, and How to Stand Out in Your Career (#607)Balaji S. Srinivasan — 5-10-Year Predictions, How to Start a New Country, Society-as-a-Service (SaaS), Bitcoin Maximalism, Memetic Warfare, How Prices Are Born, Moral Flippenings, The One Commandment, and The Power of Missionary over Mercenary (#606)Signal Over Noise with Noah Feldman — The War in Ukraine (Recap and Predictions), The Machiavelli of Maryland, Best Books to Understand Geopolitics, The Battles for Free Speech on Social Media, Metaverse Challenges, and More (#608)The Life-Extension Episode — Dr. Matt Kaeberlein on The Dog Aging Project, Rapamycin, Metformin, Spermidine, NAD+ Precursors, Urolithin A, Acarbose, and Much More (#610)Hamilton Morris and Dr. Mark Plotkin — Exploring the History of Psychoactive Substances, Synthetic vs. Natural Options, Microdosing, 5-MeO-DMT, The “Drunken Monkey” Hypothesis, Timothy Leary's Legacy, and More (#605)***For show notes and past guests, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsors.Sign up for Tim's email newsletter (“5-Bullet Friday”) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim's books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissFacebook: facebook.com/timferriss YouTube: youtube.com/timferrissPast guests on The Tim Ferriss Show include Jerry Seinfeld, Hugh Jackman, Dr. Jane Goodall, LeBron James, Kevin Hart, Doris Kearns Goodwin, Jamie Foxx, Matthew McConaughey, Esther Perel, Elizabeth Gilbert, Terry Crews, Sia, Yuval Noah Harari, Malcolm Gladwell, Madeleine Albright, Cheryl Strayed, Jim Collins, Mary Karr, Maria Popova, Sam Harris, Michael Phelps, Bob Iger, Edward Norton, Arnold Schwarzenegger, Neil Strauss, Ken Burns, Maria Sharapova, Marc Andreessen, Neil Gaiman, Neil de Grasse Tyson, Jocko Willink, Daniel Ek, Kelly Slater, Dr. Peter Attia, Seth Godin, Howard Marks, Dr. Brené Brown, Eric Schmidt, Michael Lewis, Joe Gebbia, Michael Pollan, Dr. Jordan Peterson, Vince Vaughn, Brian Koppelman, Ramit Sethi, Dax Shepard, Tony Robbins, Jim Dethmer, Dan Harris, Ray Dalio, Naval Ravikant, Vitalik Buterin, Elizabeth Lesser, Amanda Palmer, Katie Haun, Sir Richard Branson, Chuck Palahniuk, Arianna Huffington, Reid Hoffman, Bill Burr, Whitney Cummings, Rick Rubin, Dr. Vivek Murthy, Darren Aronofsky, Balaji Srinivasan, Sarah Silverman, Dr. Andrew Huberman, Dr. Michio Kaku, and many more.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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The Lucas Rockwood Show
530: The Truth About Reverse Aging with Morgan Levine PhD

The Lucas Rockwood Show

Play Episode Listen Later Aug 24, 2022 39:14


How long do you want to live? How healthy do you want to be in your later years? For many podcast listeners, healthspan is more important than lifespan, but it's difficult to figure out what–if anything⁠–can stack the deck in your favor. On this week's podcast, we'll meet PhD researcher and author, Morgan Levine, who is actively working to answer these questions.  Listen and learn:  Why exercise is probably the greatest anti-aging tool Metformin and rapamycin: do they work? Human age potential Heritability vs. epigenetics  Links Morgan Levine's Book ABOUT OUR GUEST Morgan Levine was an Assistant Professor in the department of Pathology at Yale University. She now works with Altos Labs, where she leads a research group on bioinformatics, cellular biology, and biostatistics. She is the author of, True Age: Cutting-Edge Research to Help Turn Back the Clock. Like the Show? Leave us a review Check out our YouTube channel Visit www.yogabody.com

Podcast Notes Playlist: Fitness
Dr. Peter Attia: Exercise, Nutrition, Hormones for Vitality & Longevity | Episode 85

Podcast Notes Playlist: Fitness

Play Episode Listen Later Aug 17, 2022 170:02


Huberman Lab Podcast Notes Only by clearly defining what you want in your last decade of life can you work backwards and put in place a plan to get thereTwo vectors of longevity: (1) lifespan: literally whether you are alive and breathing; (2) healthspan: how many healthy years you live – biomarkers matter less, physical & performance tests matter more (DEXA scan, VO2, fat oxidation, emotional state, etc.)ApoB is the single most important biomarker to measure – be proactive in obtaining this as early as possible! It's uncommon in the U.S. though used in Europe & other places as part of regular health check You should monitor weight but an annual DEXA scan is more valuable than tracking BMI“There's not one thing I'll tell patients that is more important than exercising.” – Peter Attia“Strength training is an essential part of our existence. It's never to late to start but you should never stop.” – Peter AttiaTry the back casting thought experiment: In detail, what do you want the last 10 years of life to look like? Then you can plan and live accordingly. Until you do, everything is abstract.Peter Attia on the Women's Health Initiative that deterred the medical community from hormone replacement therapy for women: “It's hands down the biggest screw up of the entire medical field in the last 25 years.” – Peter AttiaPhilosophical differences in prevention – Medicine 2.0: we'll treat you if it seems like disease is imminent in the next 5-10 years; Medicine 3.0: treat the causative agent nowRead the full notes @ podcastnotes.orgMy guest this episode is Dr. Peter Attia, M.D., who trained at Stanford University School of Medicine, Johns Hopkins Hospital and the National Institutes of Health (NIH). Dr. Attia is host of The Drive podcast and is a world expert on behavioral approaches, nutritional interventions, supplementation and pharmacological techniques to improve lifespan, healthspan and athletic performance. We discuss how best to evaluate your health status using routine blood work, body scans and regular tests of physical strength and endurance. Dr. Attia explains what he uses with his patients to “back-cast” their health goals as a way to design their exercise and nutritional programs. We also discuss hormone modulation and replacement therapy for both men and women. We explain how cholesterol and related factors contribute to cardiovascular disease risk and how to monitor and mitigate that risk. Dr. Attia details various supplementation, nutrition, exercise and prescription approaches useful to people in every decade of life to improve vitality, reduce their risk of disease and increase the number of years sustaining peak cognitive and physical health.  Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman Thesis: https://takethesis.com/huberman InsideTracker: https://insidetracker.com/huberman Helix Sleep: https://helixsleep.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman For the full show notes, visit hubermanlab.com Timestamps (00:00:00) Assessing Health Status & Improving Vitality  (00:02:51) Momentous Supplements  (00:03:46) Thesis, InsideTracker, Helix Sleep  (00:07:29) Lifespan: Bloodwork & Biomarkers Testing, The “4 Horseman of Disease”  (00:11:51) Healthspan: Functional Testing, Cognitive & Emotional States  (00:13:59) Blood Testing: Best Frequency  (00:16:01) DEXA Scan: Lean Mass & Fat, Bone Mineral Density & Osteoporosis  (00:22:33) Bone Mineral Density & Age-Related Decline, Strength Training, Corticosteroids  (00:29:24) Osteopenia & Osteoporosis Diagnosis, Strength Training (00:31:03) AG1 (Athletic Greens) (00:32:16) Back-casting: Defining Your “Marginal Decade”  (00:38:31) All-Cause Mortality: Smoking, Strength, VO2 max  (00:44:43) Attia's Rule of Supplementation, “Centenarian Decathlete” Physical Goals (00:49:24) Importance of Exercise, Brain Health, MET hours  (00:55:23) Nicotine & Cognitive Focus (01:03:12) Menstruation, PMS & Menopause  (01:10:10) Hormone Replacement Therapy, Menopause & Breast Cancer Risk (01:22:06) Estrogen, Progesterone & Testosterone Therapies in Women (01:26:35) Hormone Replacement Therapy in Men, SHBG & Testosterone, Insulin (01:37:23) Clomid, Pituitary, Testosterone & Cholesterol, Anastrozole, HCG (01:47:46) Fadogia Agrestis, Supplements, Rapamycin  (01:52:06) Testosterone Replacement Therapy & Fertility  (01:59:26) Total Testosterone vs. Free Testosterone (02:02:51) Cholesterol & Dietary Cholesterol, Saturated Fat, LDL & HDL, Apolipoprotein B (02:17:42) Apolipoprotein B, Diet, Statins & Other Cholesterol Prescriptions  (02:25:15) Cardiovascular Disease, Age & Disease Risk  (02:28:53) Peptides, Stem Cells, BPC157, PRP (Platelet-Rich Plasma), Injury Rehabilitation  (02:37:40) Metabolomics & Exercise  (02:40:44) GLP-1 & Weight Loss  (02:47:06) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, Instagram, Twitter, Neural Network Newsletter, Huberman Lab Clips Title Card Photo Credit: Mike Blabac Disclaimer

Podcast Notes Playlist: Latest Episodes
Dr. Peter Attia: Exercise, Nutrition, Hormones for Vitality & Longevity | Episode 85

Podcast Notes Playlist: Latest Episodes

Play Episode Listen Later Aug 17, 2022 170:02


Huberman Lab Podcast Notes Only by clearly defining what you want in your last decade of life can you work backwards and put in place a plan to get thereTwo vectors of longevity: (1) lifespan: literally whether you are alive and breathing; (2) healthspan: how many healthy years you live – biomarkers matter less, physical & performance tests matter more (DEXA scan, VO2, fat oxidation, emotional state, etc.)ApoB is the single most important biomarker to measure – be proactive in obtaining this as early as possible! It's uncommon in the U.S. though used in Europe & other places as part of regular health check You should monitor weight but an annual DEXA scan is more valuable than tracking BMI“There's not one thing I'll tell patients that is more important than exercising.” – Peter Attia“Strength training is an essential part of our existence. It's never to late to start but you should never stop.” – Peter AttiaTry the back casting thought experiment: In detail, what do you want the last 10 years of life to look like? Then you can plan and live accordingly. Until you do, everything is abstract.Peter Attia on the Women's Health Initiative that deterred the medical community from hormone replacement therapy for women: “It's hands down the biggest screw up of the entire medical field in the last 25 years.” – Peter AttiaPhilosophical differences in prevention – Medicine 2.0: we'll treat you if it seems like disease is imminent in the next 5-10 years; Medicine 3.0: treat the causative agent nowRead the full notes @ podcastnotes.orgMy guest this episode is Dr. Peter Attia, M.D., who trained at Stanford University School of Medicine, Johns Hopkins Hospital and the National Institutes of Health (NIH). Dr. Attia is host of The Drive podcast and is a world expert on behavioral approaches, nutritional interventions, supplementation and pharmacological techniques to improve lifespan, healthspan and athletic performance. We discuss how best to evaluate your health status using routine blood work, body scans and regular tests of physical strength and endurance. Dr. Attia explains what he uses with his patients to “back-cast” their health goals as a way to design their exercise and nutritional programs. We also discuss hormone modulation and replacement therapy for both men and women. We explain how cholesterol and related factors contribute to cardiovascular disease risk and how to monitor and mitigate that risk. Dr. Attia details various supplementation, nutrition, exercise and prescription approaches useful to people in every decade of life to improve vitality, reduce their risk of disease and increase the number of years sustaining peak cognitive and physical health.  Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman Thesis: https://takethesis.com/huberman InsideTracker: https://insidetracker.com/huberman Helix Sleep: https://helixsleep.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman For the full show notes, visit hubermanlab.com Timestamps (00:00:00) Assessing Health Status & Improving Vitality  (00:02:51) Momentous Supplements  (00:03:46) Thesis, InsideTracker, Helix Sleep  (00:07:29) Lifespan: Bloodwork & Biomarkers Testing, The “4 Horseman of Disease”  (00:11:51) Healthspan: Functional Testing, Cognitive & Emotional States  (00:13:59) Blood Testing: Best Frequency  (00:16:01) DEXA Scan: Lean Mass & Fat, Bone Mineral Density & Osteoporosis  (00:22:33) Bone Mineral Density & Age-Related Decline, Strength Training, Corticosteroids  (00:29:24) Osteopenia & Osteoporosis Diagnosis, Strength Training (00:31:03) AG1 (Athletic Greens) (00:32:16) Back-casting: Defining Your “Marginal Decade”  (00:38:31) All-Cause Mortality: Smoking, Strength, VO2 max  (00:44:43) Attia's Rule of Supplementation, “Centenarian Decathlete” Physical Goals (00:49:24) Importance of Exercise, Brain Health, MET hours  (00:55:23) Nicotine & Cognitive Focus (01:03:12) Menstruation, PMS & Menopause  (01:10:10) Hormone Replacement Therapy, Menopause & Breast Cancer Risk (01:22:06) Estrogen, Progesterone & Testosterone Therapies in Women (01:26:35) Hormone Replacement Therapy in Men, SHBG & Testosterone, Insulin (01:37:23) Clomid, Pituitary, Testosterone & Cholesterol, Anastrozole, HCG (01:47:46) Fadogia Agrestis, Supplements, Rapamycin  (01:52:06) Testosterone Replacement Therapy & Fertility  (01:59:26) Total Testosterone vs. Free Testosterone (02:02:51) Cholesterol & Dietary Cholesterol, Saturated Fat, LDL & HDL, Apolipoprotein B (02:17:42) Apolipoprotein B, Diet, Statins & Other Cholesterol Prescriptions  (02:25:15) Cardiovascular Disease, Age & Disease Risk  (02:28:53) Peptides, Stem Cells, BPC157, PRP (Platelet-Rich Plasma), Injury Rehabilitation  (02:37:40) Metabolomics & Exercise  (02:40:44) GLP-1 & Weight Loss  (02:47:06) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, Instagram, Twitter, Neural Network Newsletter, Huberman Lab Clips Title Card Photo Credit: Mike Blabac Disclaimer

Signal From The Noise: By Podcast Notes
Dr. Peter Attia: Exercise, Nutrition, Hormones for Vitality & Longevity | Episode 85

Signal From The Noise: By Podcast Notes

Play Episode Listen Later Aug 17, 2022


Huberman Lab: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- My guest this episode is Dr. Peter Attia, M.D., who trained at Stanford University School of Medicine, Johns Hopkins Hospital and the National Institutes of Health (NIH). Dr. Attia is host of The Drive podcast and is a world expert on behavioral approaches, nutritional interventions, supplementation and pharmacological techniques to improve lifespan, healthspan and athletic performance. We discuss how best to evaluate your health status using routine blood work, body scans and regular tests of physical strength and endurance. Dr. Attia explains what he uses with his patients to “back-cast” their health goals as a way to design their exercise and nutritional programs. We also discuss hormone modulation and replacement therapy for both men and women. We explain how cholesterol and related factors contribute to cardiovascular disease risk and how to monitor and mitigate that risk. Dr. Attia details various supplementation, nutrition, exercise and prescription approaches useful to people in every decade of life to improve vitality, reduce their risk of disease and increase the number of years sustaining peak cognitive and physical health.  Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman Thesis: https://takethesis.com/huberman InsideTracker: https://insidetracker.com/huberman Helix Sleep: https://helixsleep.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman For the full show notes, visit hubermanlab.com Timestamps (00:00:00) Assessing Health Status & Improving Vitality  (00:02:51) Momentous Supplements  (00:03:46) Thesis, InsideTracker, Helix Sleep  (00:07:29) Lifespan: Bloodwork & Biomarkers Testing, The “4 Horseman of Disease”  (00:11:51) Healthspan: Functional Testing, Cognitive & Emotional States  (00:13:59) Blood Testing: Best Frequency  (00:16:01) DEXA Scan: Lean Mass & Fat, Bone Mineral Density & Osteoporosis  (00:22:33) Bone Mineral Density & Age-Related Decline, Strength Training, Corticosteroids  (00:29:24) Osteopenia & Osteoporosis Diagnosis, Strength Training (00:31:03) AG1 (Athletic Greens) (00:32:16) Back-casting: Defining Your “Marginal Decade”  (00:38:31) All-Cause Mortality: Smoking, Strength, VO2 max  (00:44:43) Attia's Rule of Supplementation, “Centenarian Decathlete” Physical Goals (00:49:24) Importance of Exercise, Brain Health, MET hours  (00:55:23) Nicotine & Cognitive Focus (01:03:12) Menstruation, PMS & Menopause  (01:10:10) Hormone Replacement Therapy, Menopause & Breast Cancer Risk (01:22:06) Estrogen, Progesterone & Testosterone Therapies in Women (01:26:35) Hormone Replacement Therapy in Men, SHBG & Testosterone, Insulin (01:37:23) Clomid, Pituitary, Testosterone & Cholesterol, Anastrozole, HCG (01:47:46) Fadogia Agrestis, Supplements, Rapamycin  (01:52:06) Testosterone Replacement Therapy & Fertility  (01:59:26) Total Testosterone vs. Free Testosterone (02:02:51) Cholesterol & Dietary Cholesterol, Saturated Fat, LDL & HDL, Apolipoprotein B (02:17:42) Apolipoprotein B, Diet, Statins & Other Cholesterol Prescriptions  (02:25:15) Cardiovascular Disease, Age & Disease Risk  (02:28:53) Peptides, Stem Cells, BPC157, PRP (Platelet-Rich Plasma), Injury Rehabilitation  (02:37:40) Metabolomics & Exercise  (02:40:44) GLP-1 & Weight Loss  (02:47:06) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, Instagram, Twitter, Neural Network Newsletter, Huberman Lab Clips Title Card Photo Credit: Mike Blabac Disclaimer

Huberman Lab
Dr. Peter Attia: Exercise, Nutrition, Hormones for Vitality & Longevity | Episode 85

Huberman Lab

Play Episode Listen Later Aug 15, 2022 170:02 Very Popular


My guest this episode is Dr. Peter Attia, M.D., who trained at Stanford University School of Medicine, Johns Hopkins Hospital and the National Institutes of Health (NIH). Dr. Attia is host of The Drive podcast and is a world expert on behavioral approaches, nutritional interventions, supplementation and pharmacological techniques to improve lifespan, healthspan and athletic performance. We discuss how best to evaluate your health status using routine blood work, body scans and regular tests of physical strength and endurance. Dr. Attia explains what he uses with his patients to “back-cast” their health goals as a way to design their exercise and nutritional programs. We also discuss hormone modulation and replacement therapy for both men and women. We explain how cholesterol and related factors contribute to cardiovascular disease risk and how to monitor and mitigate that risk. Dr. Attia details various supplementation, nutrition, exercise and prescription approaches useful to people in every decade of life to improve vitality, reduce their risk of disease and increase the number of years sustaining peak cognitive and physical health.  Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman Thesis: https://takethesis.com/huberman InsideTracker: https://insidetracker.com/huberman Helix Sleep: https://helixsleep.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman For the full show notes, visit hubermanlab.com Timestamps (00:00:00) Assessing Health Status & Improving Vitality  (00:02:51) Momentous Supplements  (00:03:46) Thesis, InsideTracker, Helix Sleep  (00:07:29) Lifespan: Bloodwork & Biomarkers Testing, The “4 Horseman of Disease”  (00:11:51) Healthspan: Functional Testing, Cognitive & Emotional States  (00:13:59) Blood Testing: Best Frequency  (00:16:01) DEXA Scan: Lean Mass & Fat, Bone Mineral Density & Osteoporosis  (00:22:33) Bone Mineral Density & Age-Related Decline, Strength Training, Corticosteroids  (00:29:24) Osteopenia & Osteoporosis Diagnosis, Strength Training (00:31:03) AG1 (Athletic Greens) (00:32:16) Back-casting: Defining Your “Marginal Decade”  (00:38:31) All-Cause Mortality: Smoking, Strength, VO2 max  (00:44:43) Attia's Rule of Supplementation, “Centenarian Decathlete” Physical Goals (00:49:24) Importance of Exercise, Brain Health, MET hours  (00:55:23) Nicotine & Cognitive Focus (01:03:12) Menstruation, PMS & Menopause  (01:10:10) Hormone Replacement Therapy, Menopause & Breast Cancer Risk (01:22:06) Estrogen, Progesterone & Testosterone Therapies in Women (01:26:35) Hormone Replacement Therapy in Men, SHBG & Testosterone, Insulin (01:37:23) Clomid, Pituitary, Testosterone & Cholesterol, Anastrozole, HCG (01:47:46) Fadogia Agrestis, Supplements, Rapamycin  (01:52:06) Testosterone Replacement Therapy & Fertility  (01:59:26) Total Testosterone vs. Free Testosterone (02:02:51) Cholesterol & Dietary Cholesterol, Saturated Fat, LDL & HDL, Apolipoprotein B (02:17:42) Apolipoprotein B, Diet, Statins & Other Cholesterol Prescriptions  (02:25:15) Cardiovascular Disease, Age & Disease Risk  (02:28:53) Peptides, Stem Cells, BPC157, PRP (Platelet-Rich Plasma), Injury Rehabilitation  (02:37:40) Metabolomics & Exercise  (02:40:44) GLP-1 & Weight Loss  (02:47:06) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, Instagram, Twitter, Neural Network Newsletter, Huberman Lab Clips Title Card Photo Credit: Mike Blabac Disclaimer

Praxisflüsterer Podcast - Business Wissen für erfolgreiche Zahnärzte
Dr. Brad Stanfield | Langlebigkeit / Longevity

Praxisflüsterer Podcast - Business Wissen für erfolgreiche Zahnärzte

Play Episode Listen Later Aug 12, 2022 61:02


Dr. Brad Stanfield ist ein engagierter Arzt aus Neuseeland, der auf seinem YouTube Kanal Wissen vermittelt und Studien auseinander nimmt. Sein Thema: Longevity, also Langlebigkeit. - Wie kann man gesund und fit alt werden? - Wie kann man Krankheiten verhindern? - Welche Rolle spielen bestimmte Ernährungsweisen, Fasten, Nahrungsergänzungsmittel? Persönlich bin ich schon seit Jahren fasziniert von diesem Ansatz, aber auch beruflich ist es für mich sehr interessant. Denn: Zahnärztinnen und Zahnärzte sehen ihr Patientinnen und Patienten öfter als alle anderen Ärzte. Wie also können sie noch mehr beraten und mit Wissen weiterhelfen, das über die klassische Zahnmedizin hinausgeht, aber doch in direkter Verbindung zu ihr steht? Ein spannendes Interview! Viel Spaß beim Zuhören! Shownotes Der YouTube-Kanal von Dr. Brad Stanfield: https://www.youtube.com/c/DrBradStanfield/videos Dr. Brad Stanfield hat eine eigene Studie zu Rapamycin ins Leben gerufen. Ein sehr wichtiges Thema, das leider keinen Patentschutz hat, und somit von den großen Unternehmen nicht gefördert wird. Da es meiner Meinung nach medizinisch einer der besten Dinge ist, die man tun kann, möchte ich das Fundraising von Dr. Brad Stanfield unterstützen. Möglichkeiten zu spenden: 1) YouTube: Es gibt einen Spenden-Button auf der rechten Seite des folgenden Videos: https://youtu.be/thSvJF9Noys 2) Paypal: https://www.paypal.com/donate/?cmd=_s-xclick&hosted_button_id=4VYMP35U46KN2 Bitte “Brad Stanfield Trial” in das “Add Special Notes” Feld einfügen 3) Direkter Kontakt zu Lifespan.io: info@lifespan.io ----

Health Longevity Secrets
Bradley S Rosen MD: Rapamycin and Acarbose for Longevity in Practice

Health Longevity Secrets

Play Episode Listen Later Aug 9, 2022 47:27 Transcription Available


Pharmacological approaches to longevity using drugs like rapamycin and Acarbose via targeting signaling molecules like mTOR and insulin continue to see growing support. Today we speak with Bradley S Rosen MD whose practice focuses on Living Healthier and Longer through Biogerontology. Dr Rosen graduated with a degree in Mathematics and Statistics and an MD from the University of Florida. His residency was at Jules Stein Eye Institute at UCLA, followed by 2 Retina Fellowships at the Lions Eye Institute and the Royal Victorian Eye and Ear Hospital in Melbourne, Australia. In 2013 Dr. Rosen, M.D. joined a growing number of scientists and clinicians who are becoming increasingly interested in the fact that the hallmarks of aging themselves can and should be targeted for therapy.https://mtormd.com/ @DrBradleyRosen1Lu, Yuancheng, Benedikt Brommer, Xiao Tian, Anitha Krishnan, Margarita Meer, Chen Wang, Daniel L. Vera, et al. “Reprogramming to Recover Youthful Epigenetic Information and Restore Vision.” Nature 588, no. 7836 (December 3, 2020): 124–29. https://doi.org/10.1038/s41586-020-2975-4.Jiang, Zhou, Juan Wang, Denise Imai, Tim Snider, Jenna Klug, Ruby Mangalindan, John Morton, et al. “Short Term Treatment with a Cocktail of Rapamycin, Acarbose and Phenylbutyrate Delays Aging Phenotypes in Mice.” Scientific Reports 12, no. 1 (December 2022): 7300. https://doi.org/10.1038/s41598-022-11229-1.https://www.nature.com/articles/s41598-022-11229-1 *** CONNECT WITH ROBERT LUFKIN MD ON SOCIAL MEDIA ***Web: https://robertlufkinmd.com/ Twitter:https://twitter.com/robertlufkinmdYoutube: https://www.youtube.com/RobertLufkinMD*** MEMBERSHIP ***https://robert-lufkin.mykajabi.com/membership *** SPONSORSHIPS & BRANDS ***We do work with sponsors and brands. If you are interested in working with us for your health industry product or service, please contact us at: https://robertlufkinmd.com/contact  NOTE: This is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have. Never disregard professional medical advice or delay in seeking it because of something you have seen here. Robert Lufkin MD may at any time and at its sole discretion change or replace the information available on this channel. To the extent permitted by mandatory law, Robert Lufkin MD shall not be liable for any direct, incidental, consequential, indirect or punitive damages arising out of access to or use of any content available on this channel, including viruses, regardless of the accuracy or completeness of any such content.Disclaimer: We are ambassadors or affiliates for many of the brands we reference on the channel.Support the show

Live Longer World
#25 Caloric Restriction Deep-Dive & Longevity Secrets of Long-Lived Animals | Dr. Steven Austad

Live Longer World

Play Episode Listen Later Aug 4, 2022 68:36


All platforms / Episode Transcript: https://livelongerworld.substack.com/p/saustad Dr. Steven Austad is a professor in the Healthy Aging department at the University of Alabama and also scientific director of the American Federation for Aging research. He has a fascinating entry into the world of aging research - it all began with training lions! There are many open questions on the caloric restriction research for enhancing longevity and we dive into that. Further, a lot of Dr. Austad's work focuses on what long-lived animal species can teach us about living longer and healthier lives. His lab works on exotic species, like clams that live more than 500 years, and hydra that don't age at all, in order to discover aging treatments. He also tries to uncover the mysteries around why men and women respond differently to longevity therapeutics. Find the previous podcast episodes & subscribe to be notified: https://livelongerworld.substack.com/ Find me (Aastha) on Twitter: https://twitter.com/aasthajz DR. STEVEN AUSTAD LINKS: Website: https://www.stevenaustad.com/ Twitter: https://twitter.com/StevenAustad Faculty page: https://www.uab.edu/cas/biology/people/faculty/steven-n-austad CONNECT WITH AASTHA, LIVE LONGER WORLD: Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/aasthajz Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/aasthajz/ TIMESTAMPS: 0:00 Training lions 7:15 Learning from Long-lived species 9:55 Bowhead whales live 200 years 12:55 House sparrows & longevity 14:40 Study "successful" animals 18:10 Naked Mole Rats 20:45 What do bowhead whales die from? 26:05 Why do ocean animals live longest? 31:05 Beyond Caloric Restriction 36:00 Intermittent Fasting & Circadian Rhythm 42:40 Caloric Restriction for Healthy people? 46:24 Will coffee shorten your life? 49:43 The Blue Zone Myth 55:50 Young Blood, I can't get you of out my Mind 1:00:26 Hormones & Health (Growth Hormones for longevity?) 1:05:18 Sex differences in longevity Episode Show Notes: https://livelongerworld.substack.com/p/saustad POPULAR EPSIODES: - Richard Miller on Longevity Supplements: https://youtu.be/42PzfNs9egA - Matt Kaeberlein on Rapamycin: https://youtu.be/BL67DhNepfg - Michael Levin on Bioelectric Signals for Longevity: https://youtu.be/XboYI_wxDr8 - Nir Barzilai on Metformin & Centenarians: https://youtu.be/YlkBE8N7sl8 - Morgan Levine on Epigenetic Clocks: https://youtu.be/am3YKiTpCHo Thanks for watching & if you enjoy the episode, let's spread the message on longevity. You can support my work by sharing, subscribing, leaving a review on Apple podcasts, donating on Patreon, or signing up as a premium member. Aging is universal. Let's unite in this fight. Stay in good health - Aastha.

Parkinsons Recovery
Can Rapamycin be Helpful for Parkinson's Disease Patients?

Parkinsons Recovery

Play Episode Listen Later Aug 3, 2022 50:00


Ross Pelton, the Natural Pharmacist, discusses how the prescription drug rapamycin can increase longevity.  The discovery of rapamycin resulted in scientific studies that have enabled scientists to gain a totally new understanding of the aging process and how we might use this new information to improve health and delay the onset of age-related diseases. The topics in this book are collectively one of the most important breakthroughs in the science of life extension that has ever been discovered. The Rapamcyin Story: An interview with Ross Pelton, author of Rapamycin, mTOR, Autophagy & Treating mTOR Syndrome. https://www.lifeextension.com/magazine/2022/6/rapamycin Rapamycin: A Quantum Leap in Life Extension: Article was published in the Aug. 4, 2022 issue of the Townsend Leter. https://www.townsendletter.com/article/466-anti-aging-and-rapamycin/ Rapamycin: Extending Health Span and Life Span:  Article was published in Integrative Medicine: May 2022. http://imjournal.com/oa/index.html?fid=Pelton Order At:  LifeExtension.com/rapa

The Tim Ferriss Show
#610: The Life-Extension Episode — Dr. Matt Kaeberlein on The Dog Aging Project, Rapamycin, Metformin, Spermidine, NAD+ Precursors, Urolithin A, Acarbose, and Much More

The Tim Ferriss Show

Play Episode Listen Later Jul 27, 2022 147:44 Very Popular


The Life-Extension Episode — Dr. Matt Kaeberlein on The Dog Aging Project, Rapamycin, Metformin, Spermidine, NAD+ Precursors, Urolithin A, Acarbose, and Much More | Brought to you by Levels real-time feedback on how diet impacts your health, Athletic Greens all-in-one nutritional supplement, and LMNT electrolyte supplement. More on all three below.Dr. Matt Kaeberlein (@mkaeberlein) is a professor of Laboratory Medicine and Pathology at the University of Washington School of Medicine, with adjunct appointments in Genome Sciences and Oral Health Sciences. Dr. Kaeberlein's research interests are focused on understanding biological mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve quality of life for people and companion animals.Dr. Kaeberlein is the founding director of the University of Washington Healthy Aging and Longevity Research Institute, the director of the NIH Nathan Shock Center of Excellence in the Basic Biology of Aging at University of Washington, director of the Biological Mechanisms of Healthy Aging Training Program, and founder and co-director of the Dog Aging Project.Please enjoy!This episode is brought to you by Athletic Greens. I get asked all the time, “If you could use only one supplement, what would it be?” My answer is usually AG1 by Athletic Greens, my all-in-one nutritional insurance. I recommended it in The 4-Hour Body in 2010 and did not get paid to do so. I do my best with nutrient-dense meals, of course, but AG further covers my bases with vitamins, minerals, and whole-food-sourced micronutrients that support gut health and the immune system. Right now, Athletic Greens is offering you their Vitamin D Liquid Formula free with your first subscription purchase—a vital nutrient for a strong immune system and strong bones. Visit AthleticGreens.com/Tim to claim this special offer today and receive the free Vitamin D Liquid Formula (and five free travel packs) with your first subscription purchase! That's up to a one-year supply of Vitamin D as added value when you try their delicious and comprehensive all-in-one daily greens product.*This episode is also brought to you by LMNT! What is LMNT? It's a delicious, sugar-free electrolyte drink mix. I've stocked up on boxes and boxes of this and usually use it 1–2 times per day. LMNT is formulated to help anyone with their electrolyte needs and perfectly suited to folks following a keto, low-carb, or Paleo diet. If you are on a low-carb diet or fasting, electrolytes play a key role in relieving hunger, cramps, headaches, tiredness, and dizziness.LMNT came up with a very special offer for you, my dear listeners. For a limited time, you can get a free LMNT Sample Pack with any purchase. This special offer is available here: DrinkLMNT.com/Tim.*This episode is also brought to you by Levels! I wrote about the health benefits of using continuous glucose monitors (CGMs) more than ten years ago in The 4-Hour Body. At the time, CGMs were primitive and hard to use. Levels has now made this technology, and the unique insights that come from it, easy and available to everyone. Levels is making glucose monitoring simple, helping you see how food affects your health through real-time feedback. I started tracking my glucose years ago to learn more about what I should and shouldn't be eating (including quantities, time of day, etc.), based on objective data from my own, unique physiology. Keeping my blood sugar stable is critical to my daily and long-term health and performance goals. Furthermore, poor glucose control is associated with a number of chronic conditions like diabetes, Alzheimer's disease, heart disease, and obesity. It's important.If you're interested in learning more about Levels and trying a CGM yourself, go to Levels.link/Tim.*For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim's email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim's books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissPast guests on The Tim Ferriss Show include Jerry Seinfeld, Hugh Jackman, Dr. Jane Goodall, LeBron James, Kevin Hart, Doris Kearns Goodwin, Jamie Foxx, Matthew McConaughey, Esther Perel, Elizabeth Gilbert, Terry Crews, Sia, Yuval Noah Harari, Malcolm Gladwell, Madeleine Albright, Cheryl Strayed, Jim Collins, Mary Karr, Maria Popova, Sam Harris, Michael Phelps, Bob Iger, Edward Norton, Arnold Schwarzenegger, Neil Strauss, Ken Burns, Maria Sharapova, Marc Andreessen, Neil Gaiman, Neil de Grasse Tyson, Jocko Willink, Daniel Ek, Kelly Slater, Dr. Peter Attia, Seth Godin, Howard Marks, Dr. Brené Brown, Eric Schmidt, Michael Lewis, Joe Gebbia, Michael Pollan, Dr. Jordan Peterson, Vince Vaughn, Brian Koppelman, Ramit Sethi, Dax Shepard, Tony Robbins, Jim Dethmer, Dan Harris, Ray Dalio, Naval Ravikant, Vitalik Buterin, Elizabeth Lesser, Amanda Palmer, Katie Haun, Sir Richard Branson, Chuck Palahniuk, Arianna Huffington, Reid Hoffman, Bill Burr, Whitney Cummings, Rick Rubin, Dr. Vivek Murthy, Darren Aronofsky, and many more.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

STEM-Talk
Episode 139: Matt Kaeberlein discusses healthspan, longevity, and rapamycin

STEM-Talk

Play Episode Listen Later Jul 25, 2022 87:45 Very Popular


In response to several requests from listeners, we have as our guest today, Dr. Matt Kaeberlein, a professor of pathology at the University of Washington. Matt is well-known for his investigations into the basic mechanisms of aging. Much of his research in this area is focused on identifying interventions that promote healthspan and lifespan. In today's interview, we talk to Matt about the biology of aging and what he has learned about slowing the aging process.  In 1999, Matt and his colleague Mitch McVey discovered that overexpression of the SIR2 gene is sufficient to extend lifespan in yeast. SIR stands for silent information regulator, and we have an interesting discussion about how Matt's research and 1999 discovery have elevated SIR2 to the forefront of aging research. Also, some of Matt's most recent and fascinating investigations have been into rapamycin, the only known pharmacological agent to extend lifespan.  His research has shed new light on the role rapamycin plays in delaying age-related dysfunction in rodents, dogs, and humans. We also have a fun discussion with Matt about his research showing that rapamycin may have the potential to reduce the mortality of companion dogs. The paper that came out of this research landed Matt on the front page of the New York Times and received prominent play in the national and overseas media. Other topics we cover include: Matt's attempts to uncover the molecular mechanism behind lifespan extension via calorie restriction. His research into mTOR, which is a protein in every cell, and how inhibiting mTOR has been shown to extend the lifespan of insects, rodents, and animals. Matt's 2006 study that showed fasting extends lifespan in worms more than caloric restriction. And an article Matt published last year that summarized several of the most popular anti-aging diets, comparing them with classical caloric restriction. In addition to his work in his Kaeberlein Lab, Matt is the co-director of the Nathan Shock Center of Excellence in the Basic Biology of Aging and the founding director of the Healthy Aging and Longevity Research Institute at the University of Washington. He also is the founder and co-director of the Dog Aging Project. Show notes: [00:02:53] Dawn asks Matt and his youth and where he grew up. [00:03:06] Ken asks if it is true that Matt spent a good deal of his youth “up to no good.” [00:04:20] Dawn mentions that while Matt got decent grades in school, it wasn't until he went to college that he became studious. Dawn asks Matt if it true that he had originally decided to skip college. [00:05:42] Dawn asks how Matt ended up in Bellingham at Western Washington. [00:06:41] Dawn asks how in the world, despite not liking high school and working a morning shift at UPS for two years after graduating, Matt decided to head off for college and major in biochemistry of all things. [00:08:01] Ken asks what led Matt to travel across the country to Boston and MIT's biology program. [00:09:57] Ken asks why Matt decided to focus his research on the biology of aging. [00:11:57] Matt talks about what he did following his Ph.D. [00:13:15] Dawn asks Matt what kind of research he did at the University of Washington Department of Genome Sciences for his post-doc, and how this research related to aging. [00:15:10] Ken mentions that it was during Matt's undergrad that he decided to focus on the question, “To what extent are the mechanisms of aging evolutionarily conserved?” Ken asks Matt what caused him to arrive at that for his central focus. [00:19:36] Dawn mentions that the discovery by Matt, and Mitch McVey, that overexpression of SIR2 (Silent Information Regulator) is sufficient to extend life span in yeast is credited with promoting SIR2 to the forefront of aging research. Dawn goes on to mention that SIR genes are determinants of life span in yeast mother cells. Dawn asks Matt to give a quick primer on the SIR genes a...

Books on Pod
#266 - Nicklas Brendborg on JELLYFISH AGE BACKWARDS

Books on Pod

Play Episode Listen Later Jul 19, 2022 54:52


Molecular biologist Nicklas Brendborg chats with Trey Elling about JELLYFISH AGE BACKWARDS: NATURE'S SECRETS TO LONGEVITY. Topics include: Why we age (:51) How a certain jellyfish ages backwards (1:29) The unique aging of salmon (2:26) Large animals outliving small ones (3:17) The curious case of the naked mole rat (4:19) Genetics and lifespan (6:49) Why eradicating major diseases wouldn't extend average lifespan (9:20) Distinguishing the queen bee from worker bees (12:04) Antioxidant supplements bad for our health? (12:59) Hormesis (14:30) Heat shock proteins (16:25) Human growth hormone (19:30) Insulin-like Growth Factor 1, aka IGF-1 (21:25) Rapamycin and fungi (2:22) Spermadine (25:43) Telomeres (26:44) The epigenetic clock (28:33) Do old people benefit from young blood transfusions (34:13) The microbiome and aging (36:31) Fecal transplants (39:06) Caloric restriction (40:05) Insulin and the aging process (45:45) Metformin (48:33) Exercise (51:35)

Health Longevity Secrets
Robert Lufkin MD: Extending Life with Rapamycin

Health Longevity Secrets

Play Episode Listen Later Jul 19, 2022 10:11 Transcription Available


For this weeks episode we are going to look at a brief interview I recently did with James Strole about my upcoming presentation at the RAADFEST conference in October in San Diego.  While the interview is entitled ‘Extending Life with Rapamycin', I want to be clear that 1- the use of rapamycin is an off label use of an FDA approved prescription only drug, 2-rapamycin is a potentially dangerous drug that should only be used under the care of a physician with experience in this area, and 3- although extremely promising longevity results are present in animal models the longevity benefits of rapamycin in humans are still being determined. As you can tell I am looking forward all the great speakers at the RAADFEST conference this fall.  If are planning on attending please use code ‘LUFKIN' at checkout for 10% off any registration. https://raadfest.com/Support the show

Curiosity Daily
Rapamycin For Rover, H-Fueled Flight, Mind-Controlled Arms

Curiosity Daily

Play Episode Listen Later Jul 14, 2022 14:26


Today, you'll learn about how a drug that helps in human organ transplants might be able to extend the lives of man's best friend, the airline industry's potential but difficult switch to hydrogen fuel, and how a high school student is transforming prosthetics with brain waves.All dogs go to heaven.“New Drug May Help Dogs Live Longer” by Naomi Ruchimhttps://www.krtv.com/news/u-s-and-the-world/new-drug-may-help-dogs-live-longer“A Drug Discovered on Easter Island May Help Dogs Live up to Three Years Longer” by Tod Perryhttps://www.upworthy.com/a-drug-discovered-on-easter-island-may-help-dogs-live-up-to-three-years-longer?rebelltitem=2#rebelltitem2“Rapamycin's Secrets Unearthed” by Bethany Halfordhttps://cen.acs.org/articles/94/i29/Rapamycins-Secrets-Unearthed.html Planes, planes, planes.“The epic attempts to power planes with hydrogen” by Mark Piesingbbc.com/future/article/20220316-the-epic-attempts-to-power-planes-with-hydrogen“How close are hydrogen planes, really?” By Sabri Ben-Achourhttps://www.marketplace.org/2021/10/28/how-close-are-hydrogen-planes-really/“Hydrogen Explained” By US Energy Information Administrationhttps://www.eia.gov/energyexplained/hydrogen/use-of-hydrogen.phpMind over matter.“This High Schooler Invented a Low-Cost, Mind-Controlled Prosthetic Arm” by Margaret Osbornehttps://www.smithsonianmag.com/innovation/this-high-schooler-invented-a-low-cost-mind-controlled-prosthetic-arm-180979984/“High Schooler Invents Affordable, Mind-Controlled Prosthetic Arm” by Adrianna Ninehttps://www.extremetech.com/electronics/335384-high-schooler-invents-affordable-mind-controlled-prosthetic-arm“Creating a Working Brain-Controlled Transhumeral Prosthetic Arm (Make It Move)” by Benjamin Choihttps://www.instructables.com/Creating-a-Working-Brain-Controlled-Transhumeral-P/Follow Curiosity Daily on your favorite podcast app to get smarter with Calli and Nate — for free! Still curious? Get exclusive science shows, nature documentaries, and more real-life entertainment on discovery+! Go to https://discoveryplus.com/curiosity to start your 7-day free trial. discovery+ is currently only available for US subscribers.Find episode transcripts here: https://curiosity-daily-4e53644e.simplecast.com/episodes/rapamycin-for-rover-h-fueled-flight-mind-controlled-arms

Dr. Hotze's Wellness Revolution
Anti-Aging with Rapamycin with Donald Ellsworth, M.D.

Dr. Hotze's Wellness Revolution

Play Episode Listen Later Jul 6, 2022 24:07


Don't just live longer, live healthier! A natural medication that was discovered in the Eastern Islands centuries ago, is now being studied for its anti-aging properties. Rapamycin (also known as Sirolimus) was originally used as an antifungal medication and was known to suppress the immune system in high doses. More recent studies show its ability to enhance the immune system in lower doses, giving you energy, vitality, and enthusiasm for a longer, healthier life! Join Dr. Hotze and his guest Dr. Donald Ellsworth, as they discuss the anti-aging properties of Rapamycin and how it can improve your overall health as you age. The typical American lifestyle contributes to a host of health problems and disease. The book “Rapamycin” by Dr. Ross Pelton has been referenced in over 50,000 studies. Rapamycin is the most powerful drug today for people over 50! Listen today to learn how to increase your health span, not just your lifespan. Watch now and subscribe to our podcasts at www.HotzePodcast.com If you have any of the signs and symptoms mentioned on this podcast, take our free symptom checker test at https://www.hotzehwc.com/symptom-checker/

Animal Radio®
1178. Diseases That Humans Can Get From Their Cats, Dogs And Even Turtles.

Animal Radio®

Play Episode Listen Later Jun 30, 2022 81:11


Diseases Your Pet Can Give You Doc Halligan has some creepy news about Zoonotic disease that humans can get from their cats, dogs and even turtles. While the good doctor doesn't want you to be scared of your pet, she says it's good to be aware of the risks. And pregnant women....listen up! Listen Now The Misunderstood Pit-Bull The youthful and charismatic Bronwen Dickey has made her fight about the Pit-Bull. The years of research that went into her new book easily qualifies her as an expert on the breed that is banned from many big U.S. cities. Listen Now Drug May Slow Down A Dog's Aging Process An ongoing study out of the University of Washington now hopes to gain insight on the drug Rapamycin (which is used to prevent organ transplant rejection in humans) and its ability to slow down aging in canines. Researchers will follow 10,000 companion dogs of all kinds, as they age - not in labs, but dogs that actually live with their owners at home. Listen Now Service Animal Fraud There are now laws in many states making misrepresentation of a service animal a crime. For example, in Florida, the penalty carries a $500 fine and up to 60 days in jail. Lori Brooks will tell you how to spot a true service dog and what questions establishments are allowed to ask you if you have a service animal. Listen Now Read more about this week's show.

Cutting Edge Health: Preventing Cognitive Decline
#10 Dr. Matt Kaeberlein the ”Dog Aging Project” on Cutting Edge Health Audio Podcast

Cutting Edge Health: Preventing Cognitive Decline

Play Episode Listen Later Jun 23, 2022 39:38


The Dog Aging Project finds Rapamycin slows aging and prevents age-related disease. Are you one of the humans ready to give it a go?   

wise athletes podcast
#69 -- Longevity Longcuts & Shortcuts w/ Dr. Brad Stanfield

wise athletes podcast

Play Episode Listen Later Jun 17, 2022 61:12


Sponsor: RePowerU -- a free fitness practices assessment (a 10-minute questionnaire) Brad Stanfield, MD Today on episode #69, I talk with Dr. Brad Stanfield, a medical doctor and searcher for ways to optimize longevity. This is a impossibly complex subject fraught with wrong-headed shortcuts, snake oil, and marketing lies. What is aging?How to stop accelerated aging?Supplements to take to help offset the impact of aging? No mega dosing.. Some good ones: Vitamin D, omega 3, zinc, magnesium (threonate), creatine, collagen, glycine, Dr Stanfield's prediction of chemicals that will prove to make a big difference in longevity and healthspan: Rapamycin -- look after the protein / MTor type of issuesStains -- look after the fat / cholesterol issuesSGLT2 Inhibitors -- blood sugar related issues Contact info: https://drstanfield.com/ https://www.youtube.com/c/DrBradStanfield/about https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836174/

The Peter Attia Drive
#207 - AMA #35: "Anti-Aging" Drugs — NAD+, metformin, & rapamycin

The Peter Attia Drive

Play Episode Listen Later May 16, 2022 30:32 Very Popular


View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this “Ask Me Anything” (AMA) episode, Peter is joined by special guest, Dr. Matt Kaeberlein. Together they answer many questions around the field of aging with an emphasis on three specific molecules—NAD, metformin, and rapamycin—and their purported geroprotective qualities. They first discuss aging biomarkers and epigenetic clocks before breaking down the advantages and limitations of the most common experimental models being used today to study aging and pharmacological possibilities for extending lifespan. Next they dive deep into NAD and the much-hyped NAD precursors, nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN). They compare data from NAD precursors to studies on metformin and rapamycin, assessing how they stack up against each other and using the comparison as an opportunity to illustrate how to make sense of new experimental data and make smart decisions about how to approach future research. If you're not a subscriber and listening on a podcast player, you'll only be able to hear a preview of the AMA. If you're a subscriber, you can now listen to this full episode on your private RSS feed or on our website at the AMA #35 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here. We discuss: Logic behind comparing NAD precursors to rapamycin and metformin [3:40]; Aging biomarkers: current state, usefulness, and future promise [7:00]; Epigenetic clocks: definition, use case, and limitations [14:45];   Advantages and limitations of studying aging in non-humans and the strengths and weaknesses of different model systems [26:30]; Aging studies: importance of control lifespans and the problems with reproducibility [34:15]; Intro to NAD, potential role in aging, relationship to sirtuins, and more [48:15]; NAD precursors (NR and NMN): current data [1:10:00]; Human studies with NAD precursors [1:25:45]; Comparing NAD lifespan data to data from metformin and rapamycin [1:28:30]; Defining a “clean drug” and a “dirty drug” [1:38:00]; Reason for the lack of rapamycin studies in humans compared to NAD and metformin [1:41:00]; Ranking the geroprotective molecules in terms of risk and reward [1:48:00]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube  

Aging-US
Press Release: Altos Labs Research Perspective by Dr. Blagosklonny

Aging-US

Play Episode Listen Later May 11, 2022 2:02


BUFFALO, NY- May 11, 2022 – A new research perspective was published in Oncoscience journal by Mikhail Blagosklonny, M.D., Ph.D., entitled, “Altos Labs and the quest for immortality: but can we live longer right now?” “Here I discuss how combining rapamycin with other modalities may let us live long enough to benefit from future discoveries in cellular reprogramming and what needs to be done at Altos Labs to make this happen.” Altos Labs—a new anti-aging biotechnology company funded by multiple billionaire investors, including Jeff Bezos and Yuri Milner—has reported a focus on reprogramming cells in order to reverse the trajectory of diseases, and thus, reverse aging. In his research perspective, Dr. Blagosklonny writes that potential life-extension with rapamycin may allow us to win time while awaiting future discoveries that will reverse aging. “Rapamycin treatment is rapidly becoming a mainstream anti-aging intervention.” However, Dr. Blagosklonny also writes that rapamycin alone is unlikely to extend lifespan sufficiently to benefit from Altos Labs' future discoveries in our lifetime. “If Altos Labs would allocate a small percentage of its funding to develop rapamycin based drug combinations, then additional decades of life extension may be available 3–5 years from now.” “The number of potential combinations with rapamycin is enormous.” Read Dr. Blagosklonny's research perspective: https://www.oncoscience.us/article/552/text/ Correspondence to: Mikhail V. Blagosklonny Email: Blagosklonny@oncotarget.com, Blagosklonny@rapalogs.com Keywords: aging, longevity, lifespan, geroscience, rapalogs, gerostatics Follow Dr. Blagosklonny on Twitter: https://twitter.com/Blagosklonny For media inquiries, please contact media@impactjournals.com. Oncoscience Journal Office 6666 East Quaker Str., Suite 1D Orchard Park, NY 14127 Phone: 1-800-922-0957, option 4 ###

Live Longer World
#21 Selenium's Dual Role in Health & Aging in the Womb | Dr. Vadim Gladyshev

Live Longer World

Play Episode Listen Later May 10, 2022 60:16


All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/vgladyshev Dr. Vadim Gladyshev is a professor at Harvard Medical school and a Director of redox medicine at Brigham and Women's hospital, where he runs his own lab. We had a brilliant discussion which started off by talking about his work on selenium. Selenium is found is Brazil nuts and we discussed its connection to aging and cancer prevention, and also some of the harmful effects it can have. Dr. Gladyshev calls it the good, the bad, the ugly nature of selenium. Then, we discussed a fair bit on his theory of aging before and after development. Most people believe that the germline which is the reproductive cells do not age, but his lab's work has shown how the germline does in fact age. On this point, his lab also has interesting results on how rapamycin during development extended lifespan in mice. It's important to understand the basic science and understand more on the aging process in order to crack it. Dr. Gladyshev shares his views on this too and his research is certainly a step towards cracking the aging code. I hope you enjoy the conversation! Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast Sign up for Premium Subscriber Transcripts: https://www.livelongerworld.com/premium Support on Patreon: https://www.patreon.com/livelongerworldOne-Time support: https://www.paypal.com/paypalme/livelongerworld Find me on Twitter: https://twitter.com/livelongerworld VADIM GLADYSHEV LINKS: Website: https://gladyshevlab.bwh.harvard.edu/2022 Rapamycin During Development extends Lifespan: https://www.biorxiv.org/content/10.1101/2022.02.18.481092v1 LIVE LONGER WORLD LINKS: Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/livelongerworld Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/longevityfuture/ Patreon: https://www.patreon.com/livelongerworld YouTube: https://www.youtube.com/c/LiveLongerWorld Premium Subscriber: https://www.livelongerworld.com/premium TIMESTAMPS: 0:00 Vadim Gladyshev Intro 1:28 Live Longer World 2:17 Selenium's dual role in aging (the good, the bad, the ugly) 11:27 Antagonistic Pleiotropy 13:53 Selenium & Cancer 15:58 Selenium Dosage (don't get too much!) 18:30 Reactive Oxygen Species, Antioxidants & Aging 22:30 Fundamental basis of Aging 24:09 Aging is damage 29:20 Single cell Epigenetic Clocks 34:22 Aging in the Womb 42:16 Parent's lifestyle for aging in embryo 44:14 Rapamycin during development 49:06 Other compounds 51:53 Slowing Aging vs. Rejuvenation 56:08 New projects being worked on 57:17 Confidence level in extending lifespan within 30 years 59:17 Support Live Longer World Episode Show Notes: https://livelongerworld.substack.com/p/vgladyshev Live Longer World Season 1 Recap: https://livelongerworld.substack.com/p/season1 Thanks for watching & if you enjoy the episode, let's spread the message on longevity. You can support my work by sharing, liking, subscribing, leaving a review on Apple podcasts, donating on Patreon, or signing up as a premium member. Aging is universal. Let's unite in this fight. Stay in good health - Aastha.

The MenElite Podcast
Screw rapamycin, use this instead || 2 reasons why this compound is better than rapamycin.

The MenElite Podcast

Play Episode Listen Later Apr 19, 2022 15:37


Live Longer World
#18 Longevity Supplements - Interventions Testing Program Results | Dr. Richard Miller

Live Longer World

Play Episode Listen Later Apr 12, 2022 81:40


Dr. Richard Miller runs one of the labs for the Interventions Testing Program or the ITP, which is largely considered the gold standard for testing longevity drugs. This was one of the best conversations I've had on longevity supplements that affect lifespan and those that might me subject to mere hype. Dr. Miller is rigorous in his approach and states the data clearly. He also has opinions on lifespan vs. healthspan that are unique from those of most others and worth paying attention to. I genuinely walked away having learned so much from this conversation and feeling more awakened, and I hope it is useful to you too in parsing the data out there on longevity supplements. In today's episode, you will learn: - The 4 winning drugs that increase lifespan in mice as tested by the ITP: Rapamycin, Acarbose, 17-alpha estradiol, Canagliflozin - 3 other drugs that produce small lifespan benefits: NDGA, Glycine, Captopril - Drug combinations: Rapamycin + Acarbose, Rapamycin + Metformin - Drugs that show no lifespan increase in mice in the ITP: Resveratrol, Nicotinamide-Riboside (NR), Fisetin, Curcumin, MCT Oil, Green tea extract, Fish Oil + more - Richard's thoughts on lifespan vs. healthspan All platforms / Episode Show Notes / Timestamps: https://livelongerworld.substack.com/p/rmiller Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast Sign up for Premium Subscriber Summarized Show Notes: https://www.livelongerworld.com/premium Support on Patreon: https://www.patreon.com/livelongerworld One-Time support: https://www.paypal.com/paypalme/livelongerworld RICHARD MILLER LINKS: Website: http://www.richmillerlab.com/ Photography: https://richardmiller.zenfolio.com/ Interventions Testing Program: https://www.nia.nih.gov/research/dab/interventions-testing-program-itp LIVE LONGER WORLD LINKS: Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/livelongerworld Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/longevityfuture/ Patreon: https://www.patreon.com/livelongerworld YouTube: https://www.youtube.com/c/LiveLongerWorld Premium Subscriber: https://www.livelongerworld.com/premium TIMESTAMPS: 0:55 Richard Miller Intro 1:51 Richard Miller Wildlife photography 3:30 ITP - the gold standard for testing longevity drugs & winning drugs 10:51 Rapamycin, Rapamycin + Acarbose 18:48 Rapamycin + Acarbose Dosing Schedule 20:15 Combination of drugs, Rapamycin + Metformin 21:56 17-Alpha Estradiol 25:45 Canagaflozin 31:34 Does Richard take the 4 winning drugs? 32:46 3 Drugs that have small lifespan effects & promising 36:30 GPLD-1 & shared mechanisms in longevity drugs 44:04 Resveratrol in ITP 46:27 NR, NMN 52:34 Curcumin, Green Tea Extract, MCT Oil 54:54 Fisetin & Senolytics 56:12 Why most published research findings are false 1:00:03 Healthspan biomarkers at the ITP 1:02:38 Can you have healthspan without lifespan? 1:07:37 Fish Oil, Spermidine, Sulforophane 1:12:13 Unpublished data Richard is excited about 1:17:47 Flying Pigs & Aubrey De Grey 1:20:00 Exponential rise in aging research Episode Show Notes: https://livelongerworld.substack.com/p/rmiller Thanks for listening & if you enjoy the episode, let's spread the message on longevity. You can leave a review on Apple podcasts, subscribe and share the podcast. Aging is universal. Let's unite in this fight.

Pushing The Limits
Understanding the Role of Inflammation to Combat Arthritis with Dr Elizabeth Yurth

Pushing The Limits

Play Episode Listen Later Apr 7, 2022 80:00


Arthritis is a severe disease that's uncomfortable at best and debilitating at worst. It is a leading cause of disability worldwide. Most people think that arthritis only happens to the elderly, but it can affect anyone. It is a disease that begins in your 20s or results from injuries sustained as a child. Unfortunately, most of what the general public is misinformed about arthritis: what it is, how it starts, and how to treat it! In this episode, Dr Elizabeth Yurth addresses common misconceptions about arthritis. She defines the disease and offers realistic alternatives to established treatment options. If you want to learn more about longevity-based proactive measures to address arthritis, this episode is for you! Here are three reasons why you should listen to the full episode: Recognise arthritis as an inflammatory process rather than a wear-and-tear disease. Understand the importance of addressing arthritis early on — as early as your 20s! Learn how longevity studies-based supplements and treatments improve the immune system and combat arthritis. Get Customised Guidance for Your Genetic Make-Up For our epigenetics health programme, all about optimising your fitness, lifestyle, nutrition and mind performance to your particular genes, go to  https://www.lisatamati.com/page/epigenetics-and-health-coaching/. Customised Online Coaching for Runners CUSTOMISED RUN COACHING PLANS — How to Run Faster, Be Stronger, Run Longer  Without Burnout & Injuries Have you struggled to fit in training in your busy life? Maybe you don't know where to start, or perhaps you have done a few races but keep having motivation or injury troubles? Do you want to beat last year's time or finish at the front of the pack? Want to run your first 5-km or run a 100-miler? ​​Do you want a holistic programme that is personalised & customised to your ability, goals, and lifestyle?  Go to www.runninghotcoaching.com for our online run training coaching. Health Optimisation and Life Coaching Are you struggling with a health issue and need people who look outside the square and are connected to some of the greatest science and health minds in the world? Then reach out to us at support@lisatamati.com, we can jump on a call to see if we are a good fit for you. If you have a big challenge ahead, are dealing with adversity or want to take your performance to the next level and want to learn how to increase your mental toughness, emotional resilience, foundational health, and more, contact us at support@lisatamati.com. Order My Books My latest book Relentless chronicles the inspiring journey about how my mother and I defied the odds after an aneurysm left my mum Isobel with massive brain damage at age 74. The medical professionals told me there was absolutely no hope of any quality of life again. Still, I used every mindset tool, years of research and incredible tenacity to prove them wrong and bring my mother back to full health within three years. Get your copy here: https://shop.lisatamati.com/collections/books/products/relentless. For my other two best-selling books Running Hot and Running to Extremes, chronicling my ultrarunning adventures and expeditions all around the world, go to https://shop.lisatamati.com/collections/books. Lisa's Anti-Ageing and Longevity Supplements  NMN: Nicotinamide Mononucleotide, an NAD+ precursor Feel Healthier and Younger* Researchers have found that Nicotinamide Adenine Dinucleotide or NAD+, a master regulator of metabolism and a molecule essential for the functionality of all human cells, is being dramatically decreased over time. What is NMN? NMN Bio offers a cutting edge Vitamin B3 derivative named NMN (beta Nicotinamide Mononucleotide) that can boost the levels of NAD+ in muscle tissue and liver. Take charge of your energy levels, focus, metabolism and overall health so you can live a happy, fulfilling life. Founded by scientists, NMN Bio offers supplements of the highest purity and rigorously tested by an independent, third-party lab. Start your cellular rejuvenation journey today. Support Your Healthy Ageing We offer powerful third-party tested NAD+ boosting supplements so you can start your healthy ageing journey today. Shop now: https://nmnbio.nz/collections/all NMN (beta Nicotinamide Mononucleotide) 250mg | 30 capsules NMN (beta Nicotinamide Mononucleotide) 500mg | 30 capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 250mg | 30 Capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 500mg | 30 Capsules Quality You Can Trust — NMN Our premium range of anti-ageing nutraceuticals (supplements that combine Mother Nature with cutting edge science) combats the effects of aging while designed to boost NAD+ levels. Manufactured in an ISO9001 certified facility Boost Your NAD+ Levels — Healthy Ageing: Redefined Cellular Health Energy & Focus Bone Density Skin Elasticity DNA Repair Cardiovascular Health Brain Health  Metabolic Health My  ‘Fierce' Sports Jewellery Collection For my gorgeous and inspiring sports jewellery collection, 'Fierce', go to https://shop.lisatamati.com/collections/lisa-tamati-bespoke-jewellery-collection. Episode Highlights [03:30] Breaking the Misconceptions about Arthritis Arthritis is more than a wear-and-tear condition; it's an inflammatory disease process.  It is not limited to the elderly. The disease process can begin with minor injuries, even those sustained as a child. Arthritis is a combination of genetics and environmental factors triggered by trauma.  [08:25] Arthritis as an Inflammatory Disease Process   Arthritis is a disease process like neurodegenerative and cardiac illnesses.  Our bodies follow a balanced way to deal with injuries. It releases the level of cytokines that set off the body's response to healing and recovery. Afterwards, cytokine levels fall, and anti-inflammatory proteins take over. The disease process begins during Imbalance in any part of the process. It can be started as too many cytokines lead to zombie cells and lack of autophagy. [12:20] General Approaches to Addressing Arthritis  Turn off inflammatory cytokines through simple supplements like curcumin or epigallocatechin.  Turning down the inflammatory response allows the injury to heal better.  Inducing autophagy or knocking off the bad cells helps reduce injury as well.  [13:36]  Arthritis is a Preventable Disease  Arthritis is a disease that should be given more attention, as it has a significant impact on people's quality of life. It is the primary cause of disability among people of working age.  Arthritis is preventable to a large degree, despite genetics and other factors.  [18:32] Current Orthopedic Treatments for Arthritis  The focus in addressing arthritis is to treat the disease process. Steroid injections temporarily reduce inflammatory cytokines, but they also inhibit those that aid in healing. Arthroscopic surgery can provide immediate comfort. However, it can also inflict tears that can cause the rapid progression of arthritis. Back fusion can help cases of spinal instability. However, for degenerative discs, the long-term success rate of surgery is around 10% of those who undergo it. [24:09]  Degenerative Disc Disease as an Inflammatory Disease  Degenerative disc disease is an inflammatory disease caused by high levels of cytokines. This includes the nuclear factor kappa beta. The goal is to focus on the issues that cause disc destruction, such as elevated cytokine levels, rather than the disc itself. Ageing processes, like degeneration, should serve as a wake-up call to reconsider one's diet. This also includes reconsidering supplements, and exercise, as well as one's cardiovascular health. [27:18]  Changing the Perspective about Arthritis People should be aware that arthritis begins in their 20s, similar to brain disorders, heart ailments, and cancers.    All these immune and inflammatory diseases come down to curing ageing.  We need to take proactive steps and opt for longevity instead of a mechanical standard of care.  Opting for the ‘expensive' care earlier will save you time, stress, and money. People often exhaust traditional options first before pursuing longevity treatments.  [38:49] Pentosan Polysulfate: ‘A Cure for Arthritis' Pentosan polysulfate is a repurposed drug that reduces cytokines causing degenerative disc pain.  According to studies, even after just six weeks of using Pentosan Polysulfate, you can continue to reap the advantages for up to a year. [45:07] Vitamins and Supplements to Combat Arthritis  Another strategy to fight arthritis is to make sure your nutrients are optimised. Vitamins D and C, and zinc are critical but straightforward micronutrients. Epigallocatechin gallate, or EGCG, has many benefits that aid in addressing arthritis. Its benefits include muscle-building, fat loss, and myostatin blocking. [47:07] Benefits of Gaining Muscle Muscle, as an organ, produces endocrine glands, and myokines have very beneficial effects on joints.   Those with sarcopenia or muscle loss are more likely to develop joint arthritis. Electrical stimulation of muscles can be done for individuals who are further along in a disease process. Static contraction or contracting the muscles for three seconds every hour also helps muscle-building.  [51:03]  Inducing Autophagy Process Using Spermidine  Spermidine is a polyamine compound that comes from bacteria in certain foods.  Polyamine is produced by the human body as well. However, as we become older, we make less of it. It is an autophagy-Inducing agent that aids in getting rid of damaged cells.  Spermidine works better than steroids at reducing inflammation. It preserves the joints without making them worse. [54:06] Trehalose: The ‘Sugar Substitute' Trehalose is glucose that impacts oxidative stress and helps clean up the cells.  It has zero glycemic impact, which helps blood glucose under control.  Trehalose is looked at for neurodegenerative diseases but can benefit joint pain.  [56:57] Peptide Therapies as Simple, Inexpensive Aid  If you are looking for simple, inexpensive aid, collagen peptides can also be beneficial.  They typically are part of a mixture including Vitamin C, which helps cartilage cells.  A more expensive option is aggressive peptides, like BPC 157 or Body Protection Compound 157. These peptides can aid joint regeneration. It's vital to understand the role of inflammation in arthritis rather than jumping at treatments, like stem cell therapy. [59:54] The Role of Stressed Immune System  Almost every disease is related to over-aggressive, pro-inflammatory cytokines, disruption in mitochondrial function, and autophagy.  Ageing causes a significant number of diseases.  The immune system goes awry for many reasons, including viral exposures. [59:54] Antiviral Drugs, Hormones, and Fasting Antiviral drugs, hormones, and fasting can help the immune system fight diseases as healthy as possible.  EGCG and curcumin are natural compounds that have some antiviral properties. Acyclovir is also a safe choice for combatting the herpes virus and Epstein-Barr, among others.   Our immune system produces fewer hormones as we become older. Our bodies need hormones to function, so we need to replace them somehow. Hormones have huge immune-modulating properties that help stop oxidative stress.  The immune system benefits from the recovery period following a fast. It can be very beneficial to clear out dead cells. [1:08:55] Rapamycin and Metformin: The ‘Future' of Arthritis Rapamycin is a chemotherapeutic medication with a solid immune-modulating effect.  It is well-known for activating autophagy, which can lengthen lifespan in all mammalian species scientists have studied. Metformin is an inexpensive medication that keeps glucose control.  It has some interesting studies on arthritis. One study shows the overlapping benefits in cardiovascular, renal, cancer, and obesity protection.  7 Powerful Quotes “[Arthritis as an inflammatory disease process] is the same thing that goes on with COVID. Right? Yes. Why do some people die of COVID? [It's] usually not the virus itself -- it's the immune reaction to the virus.”   “So we know we have to treat [cytokines] and not the disc itself. That's the end game. Treat the problem that's causing the disc damage.”   “...[W]e're really trying to get into the heads of these [20-year-olds] and say, the [disease process starts when you're] 20. Yeah, like your brain diseases, your heart diseases, and your cancers are all those processes are starting in our 20s.”   “The plastic surgeons are doing fine. [P]eople are more than willing to spend that money on their facelifts and things like that [than] internally to feel better.”   “You can have no cartilage and no pain or no discs, and no gain. The pain is an inflammatory sign.” “Go back, go back up the tree. And then you had all of the diseases in mitochondria and information.” "Be it cancer, metabolic disease, cardiovascular disease, or neurologic arthritis, they're all the same disease. You've got to get the immune system as healthy as possible. You have to stop oxidative stress." Resources Gain exclusive access and bonuses to Pushing the Limits Podcast by becoming a patron!  Track your blood glucose in real-time with Levels Health.  Tripping Over the Truth: How the Metabolic Theory of Cancer Is Overturning One of Medicine's Most Entrenched Paradigms by Travis Christofferson  Curable: How an Unlikely Group of Radical Innovators is Trying to Transform our Health Care System by Travis Christofferson  How to Starve Cancer by Jane McLelland Want to learn more from Dr Dom? Check out Peter Attia's podcast episodes with him:  Episode 116 - AMA with Dom D'Agostino, PhD, Part I of II: Ketogenic diet, exogenous ketones, and exercise Episode 120 – AMA with Dom D'Agostino, PhD, Part II of II: Ketosis for cancer and chronic disease, hyperbaric oxygen therapy, and the effect of ketosis on female health  Episode 5 - Dom D'Agostino, PhD: ketosis, n=1, exogenous ketones, HBOT, seizures, and cancer       You can also check out other podcasts where Dr Dom was a guest here.  The 1-Week and 8-Month Effects of a Ketogenic Diet or Ketone Salt Supplementation on Multi-Organ Markers of Oxidative Stress and Mitochondrial Function in Rats  Press-pulse: a novel therapeutic strategy for the metabolic management of cancer  Ketone supplementation decreases tumour cell viability and prolongs the survival of mice with metastatic cancer  Moffitt Cancer Center  Get your exogenous ketones from Audacious Nutrition  Keto Nutrition: Website | Youtube | Instagram | Facebook Connect with Dr Dom: Twitter | LinkedIn | Instagram About Dr Elizabeth Dr Elizabeth Yurth, MD, FAARFM, ABAARM is a practising orthopedic. She specialises in sports, spine, and regenerative medicine and has over 25 years of professional experience as a practising orthopaedic physician. She is a double-Board Certified in Physical Medicine & Rehabilitation and Anti-Aging/Regenerative Medicine.  Dr Yurth has dedicated her life to longevity. In 2006, she founded the Boulder Longevity Institute, where she serves as the Medical Director. She has worked as the team physician for Stanford and Santa Clara Universities and consulted for the San Francisco 49ers and the San Jose Ballet. Dr Yurth has a dual-Fellowship in Anti-Aging and Regenerative Medicine (FAARM), and Anti-Aging, Regenerative and Functional Medicine (FAARFM) through the American Academy of Anti-Aging Medicine (A4M). She recently completed a Fellowship in Human Potential and Epigenetic Medicine.  You can learn more and connect with Dr Elizabeth on Twitter, LinkedIn, and Instagram. Enjoyed This Podcast? If you did, be sure to subscribe and share it with your friends! Post a review and share it! If you enjoyed tuning in, then leave us a review. You can also share this with your family and friends so they can know how to optimise sleep.  Have any questions? You can contact me through email (support@lisatamati.com) or find me on Facebook, Twitter, Instagram and YouTube. For more episode updates, visit my website. You may also tune in on Apple Podcasts. To pushing the limits, Lisa  

Mind & Matter
Joe Baur: Aging, Metabolism, Caloric Restriction, NAD, Resveratrol, Rapamycin, Sirtuins, Longer Life | #64

Mind & Matter

Play Episode Listen Later Mar 31, 2022 86:48 Transcription Available


Nick talks to biochemist Joe Baur, PhD, whose lab at the University of Pennsylvania studies the molecular mechanisms of aging and metabolism. These discuss: aging as a passive vs. regulated process; mechanisms of aging (DNA mutations, oxidative stress, etc.); NAD and its role in normal physiology; the biology of sirtuins; rapamycin as an immunosuppressant & modulator of aging; the effects of diet & caloric restriction on aging; the potential slowing and reversing aging, and more.USEFUL LINKSSign up for the weekly Mind & Matter newsletter[https://mindandmatter.substack.com/?sort=top]Follow Nick's work through Linktree:[https://linktr.ee/trikomes]Try Levels Health to monitor your blood sugar & optimize your diet[https://www.levelshealth.com/join?partner=MINDANDMATTER]Athletic Greens, comprehensive daily nutrition (Free 1-year supply Vitamin D w/ purchase)[https://www.athleticgreens.com/mindandmatter]Organize your digital highlights & notes w/ Readwise (2 months free w/ sub)[https://readwise.io/nickjikomes/]Learn more about our podcast sponsor, Dosist[https://dosist.com]Download the podcast & follow Nick at his website[https://www.nickjikomes.com]Support the show (https://www.patreon.com/nickjikomes)

Health Longevity Secrets
Daniel Tawfik: Rapamycin, Metformin, and Fisetin for Longevity

Health Longevity Secrets

Play Episode Listen Later Mar 29, 2022 50:49 Transcription Available


Rapamycin, metformin, and fisetin are all associated with improvements in markers associated with aging. We are now beginning to see them used by healthy individuals interested in longevity. Daniel Tawfik is the founder, developer, and CEO of HealthSpan. HealthSpan optimizes human performance through interventions that target cellular senescence. Healthspan was created to empower patients to regain control over the levers of aging that are at the foundation of most age-related diseases.Daniel holds a BS degree from UCLA in molecular, cellular, and developmental biology and physics. Daniel did his graduate research at UCLA's Protein Expression Technology Center where he studied neurometabolic disorders. http://dantawfik.com/Gethealthspan.com @dantawfikhttps://zenpatient.com/ Support the show (https://robert-lufkin.mykajabi.com/membership)

Inside the Cure with Dr. Charles Mok
Episode 16: Can Rapamycin Reverse Skin Aging?

Inside the Cure with Dr. Charles Mok

Play Episode Listen Later Mar 3, 2022 10:10


Dr. Charles Mok explores studies using the drug, Rapamycin, to reverse signs of aging. He discusses its potential and the details of how it effects our bodies, down to our cells.

Lifespan with Dr. David Sinclair
NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Episode 4

Lifespan with Dr. David Sinclair

Play Episode Listen Later Jan 26, 2022 70:30


In this week's episode, Dr. David Sinclair and co-host Matthew LaPlante zero in on drugs and supplements that have been reported to combat aspects of aging. They share the latest experimental and clinical data for NAD boosters, resveratrol, fisetin, quercetin, rapamycin, spermidine, metformin, and berberine. Given the abundance of data available, a special focus is placed on the NAD precursors nicotinamide riboside and nicotinamide mononucleotide. Known mechanisms, limitations, and/or side effects associated with these molecules are additionally highlighted. Correction and clarification: At time point 1:07:37, Dr. Sinclair says he takes 1 gram of Spermidine, but the active ingredient in the capsules is 1-2 milligrams. We apologize for the confusion. Thank you to our sponsors: Athletic Greens - https://athleticgreens.com/sinclair InsideTracker - https://insidetracker.com/sinclair Levels - https://levels.link/sinclair Our Patreon page: https://www.patreon.com/davidsinclair Lifespan book: https://amzn.to/3sUqurT Dr. David Sinclair Social: Instagram Twitter Facebook To stay up to date with David's work to democratize biological age testing and insights, visit tallyhealth.com. Matthew LaPlante's Social: Twitter Timestamps: (00:00:00) Kicking Off Episode Four: Longevity Molecules (00:02:15) Thanks the Sponsors (00:04:46) An An Additional Boost Beyond Adversity Mimetics (00:05:52) Drugs vs. Supplements and Highlight Points (00:09:54) Longevity Molecules Target the Survival Circuit (00:11:33) NAD Boosters (00:13:32) Nicotinamide Riboside (00:21:26) Nicotinamide Mononucleotide (00:29:22) NAD Intravenous Drips (00:32:45) Bioavailability of NAD Boosters (00:33:40) NAD and Cancer (00:35:33) Resveratrol (00:42:26) Red Wine and the French Paradox (0043:08) Fisetin and Quercetin (00:47:09) Rapamycin and Rapalogs (00:49:10) Spermidine (00:51:27) Metformin (01:00:27) Berberine (01:02:43) Dr. Sinclair's Protocol for Longevity Molecules (01:08:51) Wrap-up and Next Week's Episode: Interventions on the Cutting Edge (01:09:52) Options for Subscription and Support For the full show notes, including the peer-reviewed studies, visit the Lifespan podcast website. Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed. Title Card Photo Credit: Mike Blabac Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.

LongeCity interviews
Interview With Dr. Brad Stanfield

LongeCity interviews

Play Episode Listen Later Jan 18, 2022 17:16


Dr. Brad Stanfield discusses a research proposal involving rapamycin

Lifespan with Dr. David Sinclair
The Science Behind Why We Age | Episode 1

Lifespan with Dr. David Sinclair

Play Episode Listen Later Jan 5, 2022 62:36


In this episode, Dr. David Sinclair and co-host Matthew LaPlante discuss why we age. In doing so, they discuss organisms that have extreme longevity, the genes that control aging (mTOR, AMPK, Sirtuins), the role of sirtuin proteins as epigenetic regulators of aging, the process of "ex-differentiation" in which cells begin to lose their identity, and how all of this makes up the "Information Theory of Aging", and the difference between "biological age" and "chronological age" and how we can measure biological age through DNA methylation clocks. Thank you to our sponsors: Athletic Greens - https://athleticgreens.com/sinclair InsideTracker - https://insidetracker.com/sinclair Levels - https://levels.link/sinclair Our Patreon page: https://www.patreon.com/davidsinclair Social: Instagram - https://www.instagram.com/davidsinclairphd Twitter - https://twitter.com/davidasinclair Facebook - https://www.facebook.com/davidsinclairphd Timestamps: (00:00:00) Introduction (00:03:14) Goal of the Lifespan Podcast (00:07:11) Acknowledgement of Sponsors (00:10:45) Aging is a Controllable Process that can be Slowed & Reversed (00:16:42) Organisms with Extreme Longevity (00:21:47) Genes that Regulate Aging: mTOR, AMPK, Sirtuins (00:21:55) mTOR & Rapamycin (00:24:33) AMP-activated protein kinase (AMPK) & Metformin (00:30:57) Sirtuin Proteins as Epigenetic Regulators of Aging (00:35:33) Ex-Differentiation (00:43:30) Measuring Aging - Biological Age vs. Chronological Age (00:49:30) "No Law That Says We Have To Age" (00:50:33) Episode Summary & Key Takeaways - Why Do We Age? (00:54:00) Information Theory of Aging (00:57:59) Aging is a Medical Condition (01:01:00) Aging Myths - Telomeres & Antioxidants (01:01:55) Options for Subscription and Support Links: Weapon fragments in bowhead whales Rapamycin extends lifespan in mice Targeting Aging with Metformin (TAME) Trial Metformin improves healthspan and lifespan in mice Metformin reduces all-cause mortality Reprogramming to restore vision DNA methylation age Genome-wide methylation profiles & human aging rates Reversal of epigenetic aging in humans Danish twins study Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.