Podcasts about rapamycin

If you could take two pills (once a week) and live 30% longer, would you? Because a study on mice using drugs approved for humans suggests you may have to answer this question soon.

What if your body had built-in tools to regenerate itself but you've been looking in the wrong places? Dr. Khoshal Latifzai reveals overlooked therapies like peptides, shockwave, stem cells, & ketamine that go beyond symptom masking. He explains how athletes & longevity seekers use diagnostics, fasting, & advanced biologics to stay ahead of aging & feel better, faster. Meet our guest Dr. Khoshal Latifzai is a Yale-trained, board-certified emergency physician who founded Rocky Mountain Regenerative Medicine to focus on prevention, longevity & performance. Inspired by his humanitarian work & experience in critical care, he blends advanced biologics, hormone optimization & regenerative therapies to treat pain, enhance vitality & extend healthspan. His personalized approach serves athletes, executives & anyone seeking to thrive at every stage of life. Thank you to our partners Outliyr Biohacker's Peak Performance Shop: get exclusive discounts on cutting-edge health, wellness, & performance gear Ultimate Health Optimization Deals: a database of of all the current best biohacking deals on technology, supplements, systems and more Latest Summits, Conferences, Masterclasses, and Health Optimization Events: join me at the top events around the world FREE Outliyr Nootropics Mini-Course: gain mental clarity, energy, motivation, and focus Key takeaways Track biomarkers regularly through frequent, detailed bloodwork to personalize health strategies & catch negative effects early Cycle medications & supplements like peptides & metformin to prevent tolerance & maintain effectiveness Personalize metformin use since benefits, dosing & side effects vary Use low-dose rapamycin for potential longevity benefits, monitoring closely with regular biomarker testing Go beyond standard panels by checking ApoB, Lp(a) & homocysteine for better insight into cardiovascular risk Question outlier biomarkers like A1C by considering factors such as red blood cell lifespan before making assumptions Use ketamine therapy under supervision to address depression & anxiety when conventional treatments fall short Trigger targeted repair in joints or tissues using shockwave therapy to activate local stem cell healing Bank stem cells early while they're younger & more effective to improve outcomes for future injuries or illnesses Support stem cell health with regular fasting, exercise & optimized metabolic function to maintain potency with age Episode Highlights 09:39 Metformin & Rapamycin for Longevity 16:53 Underrated Biomarkers & Diagnostics 24:23 Ketamine Therapy for Brain Remodelling 45:30 Shockwave & Stem Cell Therapy Deep Dive   Links Watch it on YouTube: https://youtu.be/UbA4DzzNqN0  Full episode show notes: outliyr.com/214 Connect with Nick on social media Instagram Twitter (X) YouTube LinkedIn Easy ways to support Subscribe Leave an Apple Podcast review Suggest a guest Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you! Be an Outliyr, Nick

Dr. Stefanie Morgan joins Dr. Robert Dudley from AgelessRx to discuss a #research paper she co-authored that was #published in Volume 17, Issue 4 of Aging, entitled “Influence of rapamycin on safety and healthspan metrics after one year: PEARL trial results.” DOI - https://doi.org/10.18632/aging.206235 Corresponding author - Stefanie L. Morgan - stefanie@agelessrx.com Author interview - https://www.youtube.com/watch?v=2qlIiVh2OJs Video short - https://www.youtube.com/watch?v=z5j2nyK2HZ8 Abstract Design: This 48-week decentralized, double-blinded, randomized, placebo-controlled trial (NCT04488601) evaluated the long-term safety of intermittent low-dose rapamycin in a healthy, normative-aging human cohort. Participants received placebo, 5 mg or 10 mg compounded rapamycin weekly. The primary outcome measure was visceral adiposity (by DXA scan), secondary outcomes were blood biomarkers, and lean tissue and bone mineral content (by DXA scan). Established surveys were utilized to evaluate health and well-being. Safety was assessed through adverse events and blood biomarker monitoring. Results: Adverse and serious adverse events were similar across all groups. Visceral adiposity did not change significantly (ηp2 = 0.001, p = 0.942), and changes in blood biomarkers remained within normal ranges. Lean tissue mass (ηp2 = 0.202, p = 0.013) and self-reported pain (ηp2 = 0.168, p = 0.015) improved significantly for women using 10 mg rapamycin. Self-reported emotional well-being (ηp2 = 0.108, p = 0.023) and general health (ηp2 = 0.166, p = 0.004) also improved for those using 5 mg rapamycin. No other significant effects were observed. Conclusions: Low-dose, intermittent rapamycin administration over 48 weeks is relatively safe in healthy, normative-aging adults, and was associated with significant improvements in lean tissue mass and pain in women. Future work will evaluate benefits of a broader range of rapamycin doses on healthspan metrics for longevity, and will aim to more comprehensively establish efficacy. Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206235 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, rapamycin, geroscience, longevity, healthspan To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Everyone wants to live longer and feel better, but the flood of information on supplements, drugs, and fitness can feel overwhelming.I invited Siim Land, an expert and 8-time bestselling author on longevity, to cut through the noise and share simple, evidence-based strategies that really move the needle when it comes to health and lifespan.Siim shares incredible, science-based tips on how we can enhance our healthspan and lifespan without getting lost in the hype.We dig into why exercise, especially combining strength training with cardio, is the single most powerful anti-aging tool. Siim explains how even small changes in daily activity can dramatically reduce your risk of chronic disease and help you live longer.We also talk about what everyone is curious about - Rapamycin, Metformin, Senolytics, and more - and I'm excited to share what the research really says about these popular longevity compounds. Siim also shares why having strong social relationships may be even more important than any pill.If you want clear, practical guidance on living healthier and longer, this episode is for you. Click play and join us for a deep dive into real, sustainable longevity strategies!Key Takeaways:Introduction (00:00)Siim Land's background and journey to longevity (00:30)Exercise is the top anti-aging intervention (05:31)Benefits of moderate daily activity (08:38)Importance of resistance training for muscle and metabolism (10:42)Cardiorespiratory fitness explained with heart rate zones (15:24)Thoughts on supplement overload and key supplements (26:19)Concerns about fish oil oxidation (29:06)Sunscreen vs antioxidants debate (35:53)Senolytics and longevity drugs overview (39:05)Metformin benefits (43:15)Calorie restriction and body composition for longevity (47:11)Social relationships are key to life satisfaction (50:18)Additional Resources: ✨ Connect with Siim LandBooks: https://www.amazon.com/stores/Siim-Land/author/B019H1Z14M?Instagram: https://www.instagram.com/siimland/?hl=enFacebook: https://www.facebook.com/thesiimlandYouTube: https://www.youtube.com/c/siimland—✨ Learn more about how to live a long and pain-free life: https://joykongmd.com/ ✨ Follow me on Facebook: https://www.facebook.com/stemcelldrjoy/ ✨ Follow me on Instagram: https://www.instagram.com/dr_joy_kong/ —Dr. Joy Kong is a regenerative medicine and anti-aging expert. Her podcast is part of her mission to reduce suffering and elevate happiness. Join us every week for the latest holistic health insights that will help you live a long and pain-free life.

I'm diving deep with Regan Archibald, an absolute peptide and regenerative medicine genius to unearth mind-blowing therapies that fight aging, melt fat, heal your body, and sometimes even help you skip surgery entirely. If you're tired, feeling older than your age, or frustrated that traditional protocols aren't moving the needle, you need to hear this. We break down why most people barely scratch the surface when it comes to peptides and why these little protein messengers are the secret to amplifying your results—think faster gut healing, squashing mold toxicity, supercharging immune resilience, and getting you vibrant again on a cellular level. From innovative gut-healing protocols to stacking the right peptides for real transformation, Reagan drops gems that will completely shift your expectations about how fast and radically you can upgrade your health. We also talk muscle preserving, fat-burning, body composition-boosting peptide stacks, and why Rapamycin and Metformin could be sabotaging your muscle building goals as you age. Think next level breakthroughs: exosomes, stem cells and the new world of plasma renewal therapy that's basically an oil change for your blood. Whether you're struggling with pain, aiming for a killer physique, or curious about brain optimization and the future of longevity medicine, this episode is packed with protocols, client stories and takeaways that just might blow your current health plan out of the water. Work with Regan Archibald and his Team https://acueastwest.com/ WHAT DO MY LABS MEAN?! Try the ultimate tool to Decode Your Labs: Understand your thyroid, hormones, and blood sugar numbers to transform your health https://dramie.com/labs/ We prescribe to all 50 states!  When you're ready to FINALLY get the help you deserve… Book a free application call: https://dramie.com/book-a-call/ Shop ALL of Dr. Amie's Fixxr® Supplements: https://betterlifedoctor.com/ EARN CE Credits: "Nurses, hold-on  – here comes the exciting part: you can earn nursing CE credits by listening to our podcasts! That's right—RNegade has teamed up with podcast hosts like me who are delivering amazing content that doesn't limit you to “thinking outside-the box,” it challenges you to BLOW-UP the box by learning from innovators, pioneers, and RENEGADES in the field of health and medicine WHILE EARNING YOUR CEs!” https://rnegade.thinkific.com/?ref=4d98d0 RATE, REVIEW AND FOLLOW ON APPLE PODCASTS If you made it this far I'm impressed! That means you really love the show and I love you for that!  So I'm going to ask you for a favor. Would you please leave a quick review or even 5⭐️. I DO read them and can't tell you how much I appreciate it! Thank you in advance!❤️  Just click here it's quick and easy : https://podcasts.apple.com/us/podcast/the-thyroid-fixer/id1529800263,  Ok ONE MORE favor…would you please subscribe and follow the show? This is a win-win! It tells the podcast powers that be that you like The Thyroid Fixer Podcast AND it lets you catch all the new episodes that come out every week. Follow with this link: https://podcasts.apple.com/us/podcast/the-thyroid-fixer/id1529800263 and never miss out on a moment of the journey! CONNECT WITH ME ON SOCIAL MEDIA: Want to get your labs reviewed and your questions answered LIVE by me? Join my exclusive Facebook group, Just Fix Your Thyroid – a supportive and empowering community designed to give you the tools, guidance, and HOPE you need on your thyroid and hormone journey.

In this episode, Dr. Adam Rinde welcomes back microbiologist and PolyBio Research Foundation co-founder Dr. Amy Proal. Together, they unravel a framework for understanding chronic illnesses through the lens of persistent infections and their impact on mitochondria, immunity, and neurological health.Dr. Proal shares cutting-edge research linking pathogens like herpesviruses, cytomegalovirus, Epstein-Barr, and even latent parasites to conditions like Alzheimer's, long COVID, chronic fatigue syndrome, POTS, and more. Discover how stealth microbes can disrupt the vagus nerve, hijack mitochondrial energy systems, and weaken immune responses, setting the stage for a cascade of chronic dysfunctions.The conversation dives deep into the role of immune modulation, including promising findings around low-dose rapamycin and its potential to restore immune signaling and combat viral persistence. They also explore diet, metabolic interventions, and new clinical trials shaping the future of treatment.Whether you're a patient, practitioner, or curious mind, this episode offers profound insight into the evolving science of chronic illness and hope for emerging therapies.

0:00- Intro 1:00- Dr. Brad's background 6:00- Longevity clinics and medical tests 8:00- Vitamin D 15:00- Common supplements to avoid 18:30- Creatine 20:10- Rapamycin 37:45- Statins 48:40- High blood pressure and sodium 50:50- The future of AI and technology in medicine 57:40- Where to find Dr. Stanfield

BUFFALO, NY — May 7, 2025 — A new #research paper was #published in Aging (Aging-US) Volume 17, Issue 4, on April 4, 2025, titled “Influence of rapamycin on safety and healthspan metrics after one year: PEARL trial results.” A research team led by first author Mauricio Moel and corresponding author Stefanie L. Morgan from AgelessRx conducted a clinical trial to determine whether low-dose, intermittent rapamycin could safely improve healthspan in older adults. The findings suggest rapamycin may offer measurable benefits for physical function and overall well-being, reinforcing its potential as a safe intervention to support healthy aging. Aging remains the leading cause of chronic conditions such as heart disease, diabetes, and dementia. While medical advances have extended lifespan, many people still experience declining health and reduced mobility in later years. This growing gap between lifespan and healthspan has driven interest in therapies that target aging itself. Rapamycin, an FDA-approved drug originally used in transplant medicine, has drawn attention for its ability to influence aging-related pathways in animal studies. Until recently, its safety and benefits in healthy human populations were largely unknown. The PEARL trial is the longest study so far to explore rapamycin's use for longevity in healthy aging adults. Researchers followed 114 participants aged 50 to 85 over 48 weeks in a randomized, double-blind, placebo-controlled design. Participants received either a placebo or 5 mg or 10 mg of compounded rapamycin once per week. The study's primary goal was to measure changes in visceral fat, while secondary outcomes included lean muscle mass, blood markers, and quality-of-life assessments. The trial found that low-dose rapamycin was safe and well-tolerated, with serious side effects reported at similar rates across all groups. The most frequent minor issue among rapamycin users was mild gastrointestinal discomfort. While no significant reductions in visceral fat were observed, women taking 10 mg of rapamycin showed significant gains in lean muscle and reported reduced pain. In addition, participants taking 5 mg weekly reported improvements in emotional well-being and general health, as measured by validated surveys. “Our findings provide evidence that these rapamycin regimens are well tolerated with minimal adverse effects when administered for at least one year within normative aging individuals.” Researchers noted some limitations, including the relatively small and health-conscious participant group, which may have limited the ability to detect larger effects. The compounded form of rapamycin used also had lower absorption than commercial versions, possibly reducing its impact. Overall, the PEARL trial provides early clinical evidence that low-dose rapamycin may help support physical and emotional well-being in older adults. Further studies with larger and more diverse populations will be essential to confirm the study results and refine dosing strategies for broader application. DOI: https://doi.org/10.18632/aging.206235 Corresponding author: Stefanie L. Morgan – stefanie@agelessrx.com Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords: rapamycin, aging, healthspan, longevity, geroscience To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter: https://www.optispan.life/Dr. Matt Kaeberlein fact-checks Dr. Chris Masterjohn's essay calling rapamycin the "Worst Longevity Idea Ever," correcting misinformation about side effects (cataracts, glucose, heart) and benefits using scientific data from mouse and human studies.0:00 Intro: Tackling the "Worst Longevity Idea Ever" Essay1:06 Who is Dr. Chris Masterjohn? Expertise Questioned3:20 Debunking Mouse Claims: Cataracts, Testicular Atrophy, Glucose Metabolism12:45 Fact Check: Rapamycin's Impact on Health Span (Benefits Ignored)17:02 mTOR, Fasting Cycles & Flawed Nutrient Signaling Arguments23:26 Debunking Claims: Heart Scarring, Fatty Liver, Shrinking Testicles27:28 Dose Comparisons, Marmoset Data & Keeping Up With Science31:27 Misleading Comparisons: Organ Transplant vs. Off-Label Use33:44 Correcting Claims on Testosterone, Wound Healing & Oral Inflammation36:55 The Real Rapamycin Data, Safety Profile & Final ThoughtsProduction: Tara Mei, Nicholas Arapis, https://videocastproductions.comDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://twitter.com/optispanpodcastTwitter: https://twitter.com/optispanTwitter: https://twitter.com/mkaeberleinLinkedin: https://www.linkedin.com/company/optispanInstagram: https://www.instagram.com/optispanpodcast/TikTok: https://www.tiktok.com/@optispanhttps://www.optispan.life/Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

This rerun episode from our Greatest Hits series is all about the exciting field of longevity and biohacking. These areas are often beyond the scope of standard modern medicine for the general population but hold immense potential for those who can access them.Dr. Jeffrey Galvin from the Vitality Medical Wellness Institute joined us to share some health information you've probably never heard of before. With board certifications in Emergency Medicine and Obesity Medicine, and experience as a former Emergency Physician in the United States Air Force, Dr. Galvin founded his institute out of a desire to move beyond symptom management and address the root causes of illness, focusing on proactive prevention.He unveils the innovative work being done at the Vitality Wellness Institute and shares practical lifestyle adjustments that can significantly impact your longevity. He astutely points out that while conventional medicine aims to bring you to the average, true health optimization involves pushing beyond that.Don't miss this rerun episode to get a sneak peek into the fascinating world of longevity and how you can take proactive steps toward a healthier future!Key TakeawaysIntro (00:00)Meet Dr. Jeffrey Galvin (02:46)The dirty little secret in modern medicine (06:37)How simple lifestyle changes make all the difference (16:45)The markers of metabolic syndrome (29:02)Tools at our disposal to help with metabolic syndrome (35:45)The 5 pillars of health (39:55)The difference between normal and optimal hormone levels (41:43)Testosterone effects on both men and women (49:55)Rapamycin for longevity enhancement (1:00:51)The burgeoning world of longevity health and biohacking (1:09:07)Additional Resources- Dr. Galvin's email: drgalvin@vitalitymwi.com-  Vitality Medical Wellness Institute: https://www.vitalitymwi.com/-  A Longevity Masterclass: Emerging Science & Timeless Wisdom of Healthy Aging | Rich Roll Podcast: https://www.youtube.com/watch?v=pxEnH00YcGY—- Register for the OrthoPreneurs Summit 2025: http://opsummit2025.com/- For more information, visit: https://orthopreneurs.com/- Join our FREE Facebook group here: https://www.facebook.com/groups/OrthoPreneurs

What if aging isn't just inevitable—but modifiable? In this episode of Longevity Roadmap, Dr. Matt Kaeberlein breaks down the science of biological aging, with a focus on mTOR, epigenetics, and the hallmarks of aging like cellular senescence, mitochondrial dysfunction, and epigenetic drift. He explores the role of genetics vs. environment, the promise and pitfalls of metformin, NAD boosters, and senolytics, and why interventions like rapamycin and caloric restriction may extend health span. From the limitations of biological age tests to the importance of lean muscle mass, this conversation is a masterclass in evidence-based longevity research. Watch the full episode to understand the mechanisms of aging—and what current science says about slowing them down. Learn more about Dr. Matt Kaeberlein and Optisan: https://www.optispan.life/ - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/

Dr. Gillett, James O'Hara and Jim Lavalle scientifically dismantle biohacking, longevity, & peptides. Jim Lavalle: James LaValle is an internationally recognized clinical pharmacist, author, board-certified clinical nutritionist, and expert and educator in integrative and precision health. James is best known for his expertise in personalized integrative therapies uncovering the underlying metabolic issues that keep people from feeling healthy and vital. A thought leader in drug/nutrient depletion issues he has published 4 books and 3 databases in this area alone. He has over 35 years of experience integrating natural and integrative therapies into various medical and business models. His latest research is in drug-induced microbiome disruption.Follow Jim:► https://www.instagram.com/therealjimlavalle/► https://www.instagram.com/metabolic_elite/More about Jim:► https://www.jimlavalle.com/► http://www.metaboliccode.com/► www.metabolicelite.co00:00 Intro01:47

Dr. Stephanie Venn-Watson, a veterinary epidemiologist for the Navy, joins us again today for the second half of a two-part series. Dr. Venn Watson is passionate about raising awareness about the benefits of C15. In Part 2 today, she dives into the dangers of C15 deficiency, highlighting the differences between omega 3s and C15. She also explains why we need both and how to get C15 from our diet or by taking Fatty 15. Please listen to Part 1 first to hear about the Navy dolphins and the discovery of this fatty acid before joining us for Part 2 of our exciting interview series. Why we need C15s: For longevity To fight aging To boost energy levels To strengthen cells To reduce inflammation and the risk of heart disease, diabetes, and neurodegeneration To improve metabolic health To support brain health For better pregnancy health Dr. Venn Watson Bio: Dr. Stephanie Venn-Watson is the CEO of Seraphina Therapeutics. A seasoned veterinary epidemiologist and public health scientist, Stephanie previously served at the World Health Organization and U.S. Navy. With a life-long mission of helping people (and our fellow animals) age better, Stephanie's award-winning approach to improving human and animal health has been featured on NPR, BBC, CBS, and National Geographic. In her time as CEO, Seraphina Therapeutics has been recognized for its extensive research and education on pentadecanoic acid (C15:0). Stephanie received her B.S. in Animal Physiology and Neuroscience from UC San Diego, D.V.M. from Tufts University, M.P .H. from Emory University, and she was a National Research Council Associate with the Armed Forces Medical Intelligence Center. She is an Albert Schweitzer Fellow for Life. In this episode: Why Fatty 15 is better for us than Rapamycin or Metformin What a C15 deficiency looks like Using blood spot testing to ensure optimum C15 levels How C15s differ from Omega 3 fatty acids The many benefits of supplementing with C15s How the Fatty 15 supplement gets made, and where the ingredients are sourced   Links and Resources: Use code LONGEVITYBLUEPRINT for 15% off your first purchase of fatty15 Or use this link  Use code ENERGY to get 10% off MITOCHONDRIAL COMPLEX Use code “DRGRAY” for 10% off Danger Coffee Use code OMEGA3S to get 10% off OMEGA3S Follow Your Longevity Blueprint  On Instagram| Facebook| Twitter| YouTube | LinkedIn Get your copy of the Your Longevity Blueprint book and claim your bonuses here Find Dr. Stephanie Gray and Your Longevity Blueprint online   Follow Dr. Stephanie Gray  on Facebook| Instagram| Youtube | Twitter | LinkedIn Integrative Health and Hormone Clinic Podcast production by Team Podcast Relative Links for This Show: The Longevity Nutrient: The Unexpected Fat That Holds the Key to Healthy Aging by Stephanie Venn-Watson Guest Social Media Links: TEDx: Save the dolphins. Save the world  Discover C15 fatty15 | C15:0 Supplement on Instagram

In this first-ever AMA episode, Dave tackles your biggest biohacking questions—straight from The Upgrade Collective! From optimizing brain power to pushing the limits of cold therapy, this episode is packed with cutting-edge hacks to supercharge your body and mind. If you'd like to have your questions answered on the next AMA, click the link below for details on The Upgrade Collective membership, and get all sorts of extra biohacking add-ons for your life! In today's episode: What if you could amplify oxytocin—the “love hormone”—to build stronger relationships and lower stress? Or upgrade your cold plunge routine for max benefits in less time? Dave reveals the science behind these powerful biohacks, plus his take on rapamycin for longevity, the right way to supplement for thyroid health (without a prescription), and even how he personally overcame Asperger's traits through neuroplasticity and mitochondrial upgrades. There's even some great advice for all the parents out there! What You'll Learn: • How to naturally boost oxytocin for better relationships and emotional health • The fastest way to upgrade your cold plunge for heat shock benefits • Is rapamycin really a longevity miracle? Dave's personal take • How mitochondria impact brain power, mood, and aging—and how to fix them today! • The shocking reason some people can't process reality correctly (and how to retrain your brain) • The real truth about stem cells, exosomes, and V-cells for regeneration • The hidden dangers of selenium, thyroid supplements, and over-fasting SPONSORS -Puori | Visit https://puori.com/dave and use code DAVE for 20% storewide. -Calroy | Head to https://calroy.com/dave for an exclusive discount. Resources: • Upgrade Collective Membership: https://www.ourupgradecollective.com • Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey's Website: https://daveasprey.com • Dave Asprey's Linktree: https://linktr.ee/daveasprey • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 – Intro • 00:37 – Welcome to the Human Upgrade AMA • 01:13 – Cold Plunges and Alpha Lipoic Acid for Health • 03:11 – Hot and Cold Therapy for Optimal Health • 07:29 – Understanding Thyroid Health and Treatment • 09:09 – The Importance of Selenium • 14:41 – Stem Cells vs. Exosomes • 16:27 – Rapamycin for Longevity • 18:07 – Asperger's Syndrome and Neuroinflammation • 28:53 – Understanding Asperger's and Self-Awareness • 29:24 – The Challenge of Offering Help • 30:06 – The Importance of Reconnection Work • 31:34 – Personal Development Journey • 34:42 – The Role of Emotions in Biohacking • 35:55 – Dealing with Flashbacks and Trauma • 45:46 – The Power of Oxytocin • 49:48 – The Truth About Kale and Oxalates • 54:25 – Teaching Kids to Regulate Their Nervous System See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this episode of "Ditch the Lab Coat," Dr. Mark Bonta welcomes Dr. Behnam Banihashemi, a cardiologist specializing in cardiovascular prevention, wellness, and longevity. Dr. Banihashemi discusses the concept of Medicine 2.0, which includes advancements in pharmaceuticals and interventions that have extended life expectancy in the Western world, along with a focus on improving lifestyle choices to further enhance longevity. However, he emphasizes that the real key to living a longer, healthier life lies in addressing lifestyle factors such as fitness, nutrition, sleep, and mental health.Dr. Banihashemi explains that although cardiac procedures like stents can be life-saving during heart attacks, they do not necessarily improve life expectancy for those with stable angina. Instead, lifestyle changes have a more significant impact. He highlights the influence of pharmaceutical funding on medical research and practice, leading to an emphasis on treatments rather than preventive care.The conversation also covers the limitations of the Canadian healthcare system, which does not incentivize primary prevention, and the potential benefits of certain quick fixes like metformin or supplements like protein and creatine. Dr. Banihashemi stresses that small, consistent actions, despite not being marketable, are essential for longevity and that the healthcare system often focuses more on managing diseases than preventing them. Ultimately, individuals hold the power to take charge of their health through day-by-day lifestyle decisions, adding life to their years, not just years to their lives.Get Dr. Banihashemi's 8 Steps to Conquer Chronic Pain: A Doctor's Guide to Lifelong Relief : https://www.amazon.ca/Steps-Conquer-Chronic-Pain-Lifelong/dp/0778807118 Episode Highlights:Longevity Myths Debunked: Dr. Ben sheds light on the widespread misconception that a magic pill exists for living longer. Spoiler alert: it doesn't! Discover the habits that truly make a difference in extending not only your lifespan but also your health span.Four Pillars of Health: Learn about the core areas that Dr. Ben advocates for—Fitness, Nutrition, Sleep, and Mental Health—and how these simple, intentional choices can vastly improve your quality of life.Real Talk on Medical Interventions: Are cardiac stents the ultimate fix? Dr. Ben discusses the harsh realities of current medical practices focused on quick fixes and how lifestyle changes offer more significant benefits.The Canadian Healthcare Perspective: Ever wondered how the Canadian healthcare system affects patient care? Dr. Ben gives an insider's look into the challenges doctors face and how his new venture, the Cardiac Longevity Clinic, is pioneering a shift towards proactive, personalized healthcare.00:00 - Cardiologist Ben's Holistic Heart Health06:00 - Longevity trends in the Western world.09:08 - Impact of non-chronic mortality factors.12:04 - Cardiac stents save lives in heart attacks.16:53 - Biased pharmaceutical research investments.18:49 - Cardiology's focus: Band-Aids over causes.21:13 - Research bias in health studies.27:03 - Primary prevention system failures.28:43 - The Four Pillars for Longevity.34:43 - Integrative health consultation process.37:42 - Sustainable change through consistency.40:46 - Longevity drugs: Metformin vs. Rapamycin.45:28 - Red wine popularity: Study misinterpretations.47:00 - Wine, longevity, and confounding factors.51:13 - Patient responsibility in medication adherence.53:22 - Reflecting on longevity and lifestyle.DISCLAMER >>>>>>    The Ditch Lab Coat podcast serves solely for general informational purposes and does not serve as a substitute for professional medical services such as medicine or nursing. It does not establish a doctor/patient relationship, and the use of information from the podcast or linked materials is at the user's own risk. The content does not aim to replace professional medical advice, diagnosis, or treatment, and users should promptly seek guidance from healthcare professionals for any medical conditions.   >>>>>> The expressed opinions belong solely to the hosts and guests, and they do not necessarily reflect the views or opinions of the Hospitals, Clinics, Universities, or any other organization associated with the host or guests.       Disclosures: Ditch The Lab Coat podcast is produced by (Podkind.co) and is independent of Dr. Bonta's teaching and research roles at McMaster University, Temerty Faculty of Medicine and Queens University. 

Dr. Keith Baar is a Professor at the University of California, Davis in the Department of Physiology and Membrane Biology. During his Ph.D. studies, his research revealed that mechanical strain on muscle fibers activates the mammalian target of rapamycin (mTOR) signaling pathway, a crucial regulator of muscular hypertrophy. Subsequently, he studied the molecular dynamics of skeletal muscle adaptation to endurance training under the guidance of Dr. John Holloszy, a legend in the field of exercise physiology, considered the father of modern exercise biochemistry. Building on all of this experience, he conducted research into tendon health and the potential for engineering ligaments, which could have implications for treatment and recovery from injuries.Sponsors:Cresset prestigious family office for CEOs, founders, and entrepreneurs: https://cressetcapital.com/tim (book a call today)AG1 all-in-one nutritional supplement: https://DrinkAG1.com/Tim (1-year supply of Vitamin D (and 5 free AG1 travel packs) with your first subscription purchase.)Shopify global commerce platform, providing tools to start, grow, market, and manage a retail business: https://shopify.com/tim (one-dollar-per-month trial period)*Links to everything discussed: https://tim.blog/2025/02/26/dr-keith-baar/Timestamps:[00:00:00] Start [00:07:12] How I discovered Keith's work through a tweet about tennis elbow and rock climbing.[00:07:54] Emil Abrahamsson's hangboard training protocol.[00:09:20] The fundamental principles of strength training and connective tissue adaptation.[00:10:36] mTOR complex 1 and its role in muscle growth.[00:12:06] Engineered ligaments and the discovery of minimal effective doses for tendon adaptation.[00:13:50] The refractory period between optimal tendon loading sessions.[00:16:42] Rapamycin's effects on muscle hypertrophy.[00:18:49] Protocols for tennis elbow rehabilitation.[00:20:28] Why isometrics work better than eccentrics for tendon healing.[00:22:14] Stress shielding and how load distribution affects tendon healing.[00:29:07] The misconception about eccentric loading for tendon injuries and why velocity matters.[00:29:58] Ideal duration for isometric holds (10-30 seconds) based on injury status.[00:33:50] My elbow issues and current rehab approach.[00:36:02] Overcoming vs. yielding isometrics and optimal loading strategies.[00:47:11] Dr. Barr's movement prescription for my tennis elbow.[00:52:18] Loading timing post-surgery and RICE protocol criticism.[00:56:58] Achilles tendon rehabilitation after surgery.[01:00:18] Critique of orthopedic suturing techniques and recommendation for resorbable sutures.[01:04:02] Multiple position isometrics for tennis elbow rehabilitation.[01:07:26] Collagen synthesis, supplementation, and vitamin C timing.[01:12:59] Critique of BPC-157 and other injectable peptides for tendon healing.[01:18:19] Evaluation of orthobiologics' (PRP, prolotherapy, stem cells) effectiveness.[01:21:37] JAK-STAT inhibitor drugs and their effects on tendon growth.[01:25:35] Drugs that increase risk of tendon ruptures (fluoroquinolones, AT-1 receptor drugs).[01:29:33] How estrogen affects tendon stiffness and injury risk in women.[01:32:48] Testosterone's opposite effects on tendon compared to estrogen.[01:35:31] Protein intake recommendations and timing.[01:40:11] Ketogenic diet effects on mitochondrial biogenesis and longevity.[01:41:57] Comparison of ketogenic diet, low protein diet, and rapamycin for longevity.[01:47:19] Inflammation's role in adaptation and when to reduce it.[01:51:17] Timing of ice baths relative to training for optimal recovery.[01:52:33] Parting thoughts.*For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim's email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim's books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissPast guests on The Tim Ferriss Show include Jerry Seinfeld, Hugh Jackman, Dr. Jane Goodall, LeBron James, Kevin Hart, Doris Kearns Goodwin, Jamie Foxx, Matthew McConaughey, Esther Perel, Elizabeth Gilbert, Terry Crews, Sia, Yuval Noah Harari, Malcolm Gladwell, Madeleine Albright, Cheryl Strayed, Jim Collins, Mary Karr, Maria Popova, Sam Harris, Michael Phelps, Bob Iger, Edward Norton, Arnold Schwarzenegger, Neil Strauss, Ken Burns, Maria Sharapova, Marc Andreessen, Neil Gaiman, Neil de Grasse Tyson, Jocko Willink, Daniel Ek, Kelly Slater, Dr. Peter Attia, Seth Godin, Howard Marks, Dr. Brené Brown, Eric Schmidt, Michael Lewis, Joe Gebbia, Michael Pollan, Dr. Jordan Peterson, Vince Vaughn, Brian Koppelman, Ramit Sethi, Dax Shepard, Tony Robbins, Jim Dethmer, Dan Harris, Ray Dalio, Naval Ravikant, Vitalik Buterin, Elizabeth Lesser, Amanda Palmer, Katie Haun, Sir Richard Branson, Chuck Palahniuk, Arianna Huffington, Reid Hoffman, Bill Burr, Whitney Cummings, Rick Rubin, Dr. Vivek Murthy, Darren Aronofsky, Margaret Atwood, Mark Zuckerberg, Peter Thiel, Dr. Gabor Maté, Anne Lamott, Sarah Silverman, Dr. Andrew Huberman, and many more.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Can You Mimic Fasting—Without Actually Fasting? Chris Rhodes, a biochemist and longevity researcher, joins Dave to reveal a groundbreaking fasting mimetic that could revolutionize how we approach aging, metabolism, and health. Fasting is one of the most powerful tools for longevity, but what if you could achieve the same benefits without hunger, energy crashes, or social sacrifices? Scientists have identified key compounds that mimic fasting at the cellular level—offering a way to extend lifespan, boost metabolism, and enhance cognitive function without giving up food. Enter Mimio, a blend of four key molecules naturally produced during fasting, is engineered to deliver the life-extending benefits of fasting—without starvation. For decades, fasting has been the gold standard for longevity, but over-fasting can wreck hormones, metabolism, and muscle mass. So, what if you could get the benefits of a 36-hour fast without the downsides? Chris breaks down the science behind fasting, autophagy, and the game-changing compounds that trick your body into entering a fasted state—even while eating. What You'll Learn: • The optimal fasting window for maximizing lifespan (Hint: It's not 16 hours) • The four fasting metabolites that extend life by 96% • How Mimio mimics fasting benefits—without giving up food • The real reason over-fasting destroys your metabolism and hormones • Why traditional longevity drugs (Metformin, Rapamycin) fall short • Can you build muscle and burn fat at the same time? The science of mTOR & AMPK • Why Big Pharma doesn't want you to know about this breakthrough *** Get 20% off Mimio at mimiohealth.sjv.io/3J9abX with code: DAVE *** Sponsors:Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial.Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order.Resources: • Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Mimio Instagram: https://www.instagram.com/mimiohealth/ • Mimio Website: https://mimiohealth.com/ • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey's Website: https://daveasprey.com • Dave Asprey's Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 – Intro • 00:58 – Fasting & Longevity • 01:88 – Optimal Fasting Length • 03:39 – Alternate Day Fasting: Pros & Cons • 05:50 – Key Fasting Compounds • 07:34 – Spermidine & Longevity Molecules • 11:41 – FDA Roadblocks on Natural Compounds • 15:37 – AI, Big Data & Longevity Research • 31:19 – Mimio's Impact on Testosterone & Aging • 35:16 – Longevity & Death Philosophy • 36:48 – Biohacking Origins • 37:03 – Metabolism & Cognitive Function • 38:35 – Unexpected Effects of Fasting • 40:43 – Fasting & Circadian Rhythms • 43:09 – Mimio Science & Benefits • 45:14 – Mimio in a Daily Routine • 55:05 – Men vs. Women: Fasting Differences • 01:02:23 – Future of Nutrition & Biohacking • 01:07:21 – Conclusion & Discount Code See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Learn more about rapamycin here.https://www.alluremedical.com/exploring-rapamycin-cream-a-breakthrough-in-anti-aging-skincare/In one of our most memorable episodes, Dr. Charles Mok delves into the ins and outs of topical rapamycin, also known as sirolimus cream, and how it promotes youthful skin. Rapamycin pills are FDA-approved for certain conditions, and their topical forms are used to suppress the growth of tumors.In a split-body study conducted by Drexel University, which used a very weak strength of rapamycin cream to examine signs of aging on the skin, the treated side produced younger-looking skin with fewer wrinkles, smaller pores, and less damage to the elastin.Another remarkable benefit of sirolimus cream is its ability to lessen senescent or zombie cells, which are cells that have stopped dividing and replicating and can lead to organ dysfunction and organ failure. Tune in to the Inside the Cure Podcast -  Topical Rapamycin for Younger-Looking Skin.————————————————————————————————Subscribe to Inside the Cure on Apple Podcasts and leave a 5-star review! https://podcasts.apple.com/us/podcast/inside-the-cure-with-dr-charles-mok/id1495870043?uo=4Read the latest research and advice from the doctors at Allure Medical:https://www.alluremedical.com/books/Dr. Charles Mok received his medical degree from Chicago College of Osteopathic Medicine, Chicago, Illinois in 1989. He completed his medical residency at Mount Clemens General Hospital, Mt. Clemens, Michigan. He has worked with laser manufacturing companies to improve their technologies; he has performed clinical research studies and has taught physicians from numerous other states. His professionalism and personal attention to detail have contributed to the success of one of the first medical spas in Michigan.LinkedIn: https://www.linkedin.com/in/charles-mok-4a0432114/Instagram: https://www.instagram.com/alluremedicals/Website: https://www.alluremedical.com/YouTube: https://www.youtube.com/@AllureMedical Amazon Store: https://www.amazon.com/stores/Dr.-Charles-Mok/author/B0791M9FZQ?ref=ap_rdr&store_ref=ap_rdr&isDramIntegrated=true&shoppingPortalEnabled=true #Rapamycin #TopicalRapamycin #AntiAging #SkinCare #YoungerLookingSkin #YouthfulSkin #Longevity #LongLife #SenescentCells #CellRejuvenation #AestheticMedicine #Health #Wellness #HealthPodcast

Subscribe to our channel: https://www.youtube.com/@optispanDr. Greg Fahy discusses his groundbreaking research on thymus regeneration, immune system rejuvenation, and the role of growth hormone, DHEA, and metformin in reversing aging-related immune decline. He explains the TRIM protocol, the impact of thymic involution on longevity, and the potential for improving vaccine response and overall health. This conversation explores immune function, senescent cell clearance, and epigenetic aging clocks.0:00 - Introduction & Guest Introduction2:05 - The Origins of the TRIM Protocol6:30 - Growth Hormone & Thymus Regeneration in Rats12:40 - Growth Hormone, Insulin Resistance & DHEA20:10 - Why Thymus Regeneration Matters for Longevity27:50 - Thymic Involution & Its Role in Aging35:45 - Measuring Thymic Function & Immune Rejuvenation42:15 - Rapamycin, Thymus, and Immune System Enhancement50:20 - Human Trials: Thymus Regeneration & Exercise Performance1:03:00 - The Future of Anti-Aging & Immune RestorationProducers: Tara Mei, Nicholas ArapisVideo Editor: Jacob KeliikoaDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://twitter.com/optispanpodcastTwitter: https://twitter.com/optispanTwitter: https://twitter.com/mkaeberleinLinkedin: https://www.linkedin.com/company/optispanInstagram: https://www.instagram.com/optispanpodcast/TikTok: https://www.tiktok.com/@optispanhttps://www.optispan.life/Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

In this episode, I sit down with Dr. Adam Bataineh, a top expert in preventative healthcare and longevity. If you've ever wondered whether aging is really inevitable or if there's a way to slow it down (or even reverse it), this is the episode for you.We're talking cutting-edge science, biohacking tricks, and real-world strategies to help you live longer, healthier, and stronger. Dr. Adam breaks down everything from why aging is the root cause of most diseases to how to track your biological age like a pro.So, grab your coffee, matcha, or protein shake, and let's dive in.What You'll Learn in This EpisodeAging and disease – Why aging is behind diseases like cancer, heart disease, and metabolic issuesMuscle vs. longevity – Should you build more muscle or focus on calorie restriction? (Spoiler: balance is key)VO2 max and lifespan – The one fitness metric that predicts how long and well you'll liveBiohacking and longevity drugs – Rapamycin, Ozempic, and other tools that could change the gameWhy one-size-fits-all health advice doesn't work – How personalized medicine is the futureBig Takeaways from the EpisodeAging is not set in stone. Science is proving that we can slow it down or even reverse it with the right strategies.Muscle is a longevity cheat code. It's not just about looking strong; muscle mass helps regulate blood sugar and metabolic health.VO2 max is king. Want to know your true health status? Start tracking your cardio fitness level.Timing is everything. Sleep in a cool, dark room, get sunlight early in the day, and avoid late-night meals for better health.Supplements and drugs can help, but lifestyle is key. Tools like rapamycin, GLP-1 agonists, and omega-3s are promising, but they're not magic.5 Things You Can Do Today to Improve Your Health and LongevityTrack your biomarkers. Get regular blood tests, check your VO2 max, and monitor your health like a biohacker.Move more, sit less. Strength training and cardio are the best anti-aging formulas.Align with your circadian rhythm. Get morning sunlight, avoid blue light at night, and optimize your sleep.Be mindful of mTOR and calories. Fasting, eating protein at the right times, and avoiding overeating can boost longevity.Dial in your supplements. If you're lacking key nutrients, consider omega-3s, magnesium, or creatine to support your health.

In this fascinating episode, I dive into an incredible chat with the renowned Dr. Elizabeth Yurth. Known for her expertise in longevity, biohacking, and cellular medicine, Dr. Yurth shares game-changing insights into how repurposed drugs and peptides can enhance weight loss and promote longevity. We tackle the secrets behind microdosing treatments and repurposing drugs like Cialis for vastly improved vascular health, cognitive function, and even better orgasms for women! Trust me, you'll be jotting down notes at lightning speed as she breaks down how these unconventional methods can transform your health journey. But wait, there's more! We also discuss the mystery of peptides and bioregulators, crucial allies in the quest for enhanced healing and immunity. And yes, we even dive into hormones and anabolics, revealing how they can be your secret weapon to achieve peak physical and mental performance. Whether you're battling weight gain, fatigue, or just want to boost your badass meter during perimenopause and menopause, Dr. Yurth's insights are pure gold. Episode Key Insights: The role of repurposed drugs like Cialis in improving vascular and mitochondrial health. Metformin's impact on longevity and its downsides related to muscle loss. The use of GLP1 agonists for metabolic health and longevity without muscle loss. Rapamycin's potential as a powerful longevity drug when cycled properly. The benefits and potential side effects of low dose naltrexone for autoimmune diseases. Amlaxinox's role in reducing inflammation and its unexpected weight loss benefit. The importance of peptides, especially thymus-derived ones, for maintaining health and longevity. The versatility of peptides like BPC and Thymus beta 4 in promoting healing and repair. Anabolic steroids like oxandrolone and nandrolone for muscle and bone health, with less androgenic effects. The emerging role of bioregulators and their potential benefits for circadian rhythm and adrenal support. Connect with Dr. Elizabeth Yurth: Boulder Longevity Institute (BLI): https://boulderlongevity.com/ BLI's Human Optimization Academy: https://bli.academy/ Follow @dryurth Podcast Ad: Hormone Solutions by Karen Martel https://karenmartel.com/shop/?wpam_id=5 Use Code: DRAMIE for 10% off WHAT DO MY LABS MEAN?! Try the ultimate tool to Decode Your Labs: Understand your thyroid, hormones, and blood sugar numbers to transform your health https://dramie.com/labs/ We prescribe to all 50 states!  When you're ready to FINALLY get the help you deserve… Book a free application call: https://dramie.com/book-a-call/ Shop ALL of Dr. Amie's Fixxr® Supplements: https://betterlifedoctor.com/ EARN CE Credits: "Nurses, hold-on – here comes the exciting part: you can earn nursing CE credits by listening to our podcasts! That's right—RNegade has teamed up with podcast hosts like me who are delivering amazing content that doesn't limit you to “thinking outside-the box,” it challenges you to BLOW-UP the box by learning from innovators, pioneers, and RENEGADES in the field of health and medicine WHILE EARNING YOUR CEs!” https://rnegade.thinkific.com/?ref=4d98d0 CONNECT WITH ME ON SOCIAL MEDIA: Want to get your labs reviewed and your questions answered LIVE by me? Join my exclusive Facebook group, Just Fix Your Thyroid – a supportive and empowering community designed to give you the tools, guidance, and HOPE you need on your thyroid and hormone journey.

Subscribe to our channel: https://www.youtube.com/@optispanIn this video we discuss current studies relating to Rapamycin use and it's effects on brain function, specifically for APOE4 carriers. This data may (or may not) provide evidence to support the claim that Rapamycin can be beneficial for those with the APOE4 variant.0:00 - Introduction1:58 - Should APOE4 Carriers Take Rapamycin? 3:30 - What is APOE and APOE4? 13:06 - Why Knowing Your APOE Status Matters 15:03 - The Case for Rapamycin and APOE4 Carriers 22:52 - Study Findings32:53 - Comparing Rapamycin to Lifestyle Interventions 37:40 - Could Rapamycin Benefit E3/E3 Carriers? 38:44 - Speculation: Rapamycin and Traumatic Brain Injury Producers: Tara Mei, Nicholas ArapisVideo Editor: Jacob KeliikoaDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://twitter.com/optispanpodcastTwitter: https://twitter.com/optispanTwitter: https://twitter.com/mkaeberleinLinkedin: https://www.linkedin.com/company/optispanInstagram: https://www.instagram.com/optispanpodcast/TikTok: https://www.tiktok.com/@optispanhttps://www.optispan.life/Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

Curious how you can improve your health span? Dr Harpal Bains, an expert in longevity medicine, joins Liz to reveal the effect hormones, vitamins and medical supplements can have on longevity.Harpal and Liz discuss how we can shift from cure to prevention when it comes to age-related diseases., normalising versus optimising testosterone levels as we age, and the importance of cholesterol for our brain health.They also cover other surprising lifestyle changes that can help to support longevity and health span.Links mentioned in the episode:Visit the Harpal Clinic websiteLearn more about Rapamycin and longevityPurchase A Better Second Half by Liz EarleEmail us your questions at podcast@lizearlewellbeing.com OR leave a voicemail, text, WhatsApp message or WhatsApp voicenote our number - 07518 471846 for the chance to be featured on the show Hosted on Acast. See acast.com/privacy for more information.

Can personalized medicine unlock the secrets to living longer and healthier lives? In this episode of Longevity by Design, host Dr. Gil Blander sits down with Dr. David Barzilai, a renowned longevity physician and founder of Barzilai Longevity Consulting, to explore the science of extending healthspan through precision and innovation.Dr. Barzilai shares his journey into biogerontology and longevity science, unpacking key concepts like the hallmarks of aging, the potential of lifestyle interventions, and the translation of findings from animal models to human health. He highlights how evidence-based lifestyle medicine—centered on nutrition, exercise, sleep, and stress management—can be tailored to individual needs using biomarker-driven strategies for maximum impact.The conversation delves into some of the most promising longevity interventions, from gerotherapeutics to cutting-edge supplements. Dr. Barzilai emphasizes the power of personalized approaches in optimizing healthspan and lifespan, offering listeners practical, science-backed insights to take charge of their longevity journey.Engaging and informative, this episode is essential listening for anyone curious about the future of longevity medicine and the innovations shaping how we age. Guest-at-a-Glance

BUFFALO, NY- January 15, 2025 – A new priority #review was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) on January 12, 2025, entitled “Mikhail ‘Misha' Blagosklonny's enduring legacy in geroscience: the hyperfunction theory and the therapeutic potential of rapamycin.” This review, written by Dr. David A. Barzilai, from Geneva College of Longevity Science and Healthspan Coaching LLC, summarizes the outstanding scientific contributions of the late Dr. Mikhail "Misha" Blagosklonny, Founding Editor-in-Chief of Aging. Dr. Blagosklonny's research changed how researchers and scientists think about aging by introducing a new theory and promoting the use of rapamycin, an mTOR inhibitor, to slow aging and extend healthy life. Published shortly after his passing, this review honors Dr. Blagosklonny's work and highlights how it challenged the traditional belief that aging is caused mainly by accumulated damage in the body. Instead of describing aging as an accumulation of cellular damage, Dr. Blagosklonny's Hyperfunction Theory redefined it as an ongoing biological process that goes into "overdrive" and leads to age-related diseases such as cancer, cardiovascular problems, and memory loss. He identified the mTOR pathway—an important growth signal in the body—as a key driver of this process. His research showed that by using rapamycin, which slows down mTOR activity, it is possible to reduce aging-related diseases and promote longer, healthier lives. Research supports many of Dr. Blagosklonny's predictions about rapamycin's benefits. Studies show that it can improve immune responses in older adults, making vaccines more effective. Other studies suggest rapamycin may help protect the heart, reduce harmful brain inflammation, and prevent the buildup of proteins linked to Alzheimer's disease. Dr. Blagosklonny also proposed that rapamycin could reduce cancer risk by preventing excessive growth signals that contribute to tumor development. Believing in rapamycin's potential as a “longevity drug," Dr. Blagosklonny advocated for its careful use with medical supervision and precise dosing. He called for further research and even envisioned “longevity clinics” where personalized anti-aging treatments could be provided. The review also highlights ongoing scientific efforts to refine rapamycin therapies and explore new options with fewer side effects. In conclusion, Dr. Blagosklonny has inspired a global shift toward viewing aging as a condition that can be managed rather than an inevitable decline. His research has left a legacy in the fields of geroscience, aging, and cancer prevention. “This contribution will undoubtedly be remembered in the coming decades and beyond as an innovative contribution to our theoretical grasp of the aging process and a foundation for exploring effective therapeutic approaches.” DOI - https://doi.org/10.18632/aging.206189 Corresponding author - David A. Barzilai - david.longevity@gmail.com Video short - https://www.youtube.com/watch?v=3iOcIqfQdyI Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts About Aging-US The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.) Please visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Third week of January, what'd you miss in vet med?AI hits Animal Health Drug CreationTexas A&M pursues Rapamycin for agingMars invests in IndiaTax Laws in Spain, and US counterpartsHelpful links:The Bird Bath substackDog Aging Project2025 Animal Health Summit Emerging Company Application

  Originally developed as an immunosuppressant, rapamycin is now being studied for its wide-ranging potential in oral health—particularly in treating periodontitis, oral dysbiosis, and oral cancer. Anne O. Rice, BS, RDH, CDP, FAAOSH   Read by Jackie Sanders Link: https://www.rdhmag.com/pathology/oral-systemic/article/55237017/is-rapamycin-the-next-big-breakthrough-in-periodontitis-and-oral-cancer-treatment 

In this episode, Dr. Peter Dobias sits down with Dr. Kevin Toman, a veterinarian with nearly four decades of experience, to discuss the evolving world of pet healthcare. Dr. Toman shares his personal journey from practicing conventional veterinary medicine to adopting a more integrative approach — combining traditional methods with innovative therapies like herbal medicine, acupuncture, and laser therapy.The conversation highlights Rapamycin and how it has the potential to help extend a dogs lifespan. Dr. Toman explains how Rapamycin, along with other personalized care strategies, is changing how chronic conditions, heart disease, cancer, and aging, are managed in pets.Key Topics Include:Annual vaccinations and early spays/neuters.Treating cancer and chronic conditions with RapamycinThe importance of focusing on a pet's health span to enhance quality of life during aging.This episode is essential listening for pet owners interested in holistic, forward-thinking approaches to pet care. Gain insights into how integrative medicine can revolutionize your pet's well-being and learn actionable strategies for supporting your aging companion's health and happiness.__________________________________________ An article that you won't want to miss:https://peterdobias.com/blogs/blog/is-spay-and-neuter-really-the-best-choice-for-your-dogCheck out the Fab4 essential supplements here:https://peterdobias.com/products/fab4-bundle__________________________________________Visit our website:https://peterdobias.comVisit us on social media:FacebookInstagramTwitter#PetHealth #Rapamycin #HealthandLongevity

In today's VETgirl online veterinary continuing education podcast, Dr. Amy Kaplan, CVMA, DACVECC, MRCVS discusses the important question, does rapamycin halt progression of left ventricular hypertrophy in feline HCM? Listen to find out!

Professor David Putrino is a physiotherapist with a PhD in Neuroscience. He is currently the Director of Rehabilitation Innovation for the Mount Sinai Health System, and a Professor in the Department of Rehabilitation and Human Performance at the Icahn School of Medicine at Mount Sinai. Professor Putrino recently opened the Mount Sinai Cohen Center for Recovery from Complex Chronic Illness in New York also known as (CoRE) and serves as CoRE's Family Director and is also a member of PolyBio's Long COVID Research Consortium.Today we talk about the pathophysiology of Long COVID in the context of describing research into targeted treatments for the disease.REFERENCES1 Proal AD, VanElzakkerMB, Aleman S, Bach K, Boribong BP, Buggert M, Cherry S, Chertow DS, Davies HE, Dupont CL, Deeks SG. SARS-CoV-2 reservoir in post-acute sequelae of COVID-19(PASC). Nature Immunology. 2023 Oct;24(10):1616-27.2 Klein J, Wood J,Jaycox JR, Dhodapkar RM, Lu P, Gehlhausen JR, Tabachnikova A, Greene K, Tabacof L, Malik AA, Silva Monteiro V. Distinguishing features of Long COVID identified through immune profiling. Nature. 2023 Nov 2;623(7985):139-48.3 Long COVID low-dose Rapamycin clinical trial4 Lumbrokinase LongCOVID & ME/CFS clinical trial5 Silva J, Takahashi T, Wood J, Lu P, Tabachnikova A, Gehlhausen JR, Greene K,Bhattacharjee B, Monteiro VS, Lucas C, Dhodapkar RM. Sex differences insymptomatology and immune profiles of Long COVID. medRxiv. 2024 Mar 2:2024-02.6 VanElzakker MB, Bues HF, Brusaferri L, Kim M, Saadi D, Ratai EM, Dougherty DD, Loggia ML. Neuroinflammation in post-acute sequelae of COVID-19 (PASC) as assessed by [11C] PBR28 PET correlates with vascular disease measures. Brain, Behavior, and Immunity.7 Fernández-CastañedaA, Lu P, Geraghty AC, Song E, Lee MH, Wood J, O'Dea MR, Dutton S, Shamardani K, Nwangwu K, Mancusi R. Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation. Cell. 2022 Jul 7;185(14):2452-68.

Subscribe to our channel: https://www.youtube.com/@optispan In this episode, Matt and Brian Kennedy delve into the potential benefits and side effects of interventions like Rapamycin, the role of biomarkers, and optimal approaches to enhancing healthspan and cognitive function. Together they highlight the challenges of supplement use, aging research methodologies, and regulatory hurdles like the FDA's stance on aging. They address emerging ideas such as leveraging AI for aging research, the importance of lifestyle factors like diet and sleep, and the need for actionable biomarkers. The session is a candid exchange of expert opinions, tackling scientific controversies and practical strategies for healthy aging. Producers: Tara Mei, Nicholas Arapis Video Editor: Jacob Keliikoa DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices. More places to find us: Twitter: https://twitter.com/optispanpodcast Twitter: https://twitter.com/optispan Twitter: https://twitter.com/mkaeberlein Linkedin: https://www.linkedin.com/company/optispan Instagram: https://www.instagram.com/optispanpodcast/ TikTok: https://www.tiktok.com/@optispan https://www.optispan.life/

Learn more about Rapamycin and book your first session with Allure Medical.https://www.alluremedical.com/promising-anti-aging-drugs-may-reverse-skin-aging/Can Rapamycin prolong human life?In this episode, Dr. Charles Mok talks about topical Sirolimus (Rapamycin) and its skincare benefits. He discusses why it is studied to expand the length of healthspan and lifespan in animals, including humans, and why a lot of doctors use Rapamycin as part of an anti-aging regimen.Discover scientific studies that prove how Sirolimus can improve the quality of the skin to look better and younger. He also walks us through the proper timing of medication when taking it as part of a skincare regimen for quick improvement of the skin. Tune in to the Inside The Cure Podcast — Sirolimus (Rapamycin): Skin Care Benefits.————————————————————————————————Subscribe to Inside the Cure on Apple Podcasts and leave a 5-star review! https://podcasts.apple.com/us/podcast/inside-the-cure-with-dr-charles-mok/id1495870043?uo=4Read the latest research and advice from the doctors at Allure Medical: https://www.alluremedical.com/books/ Dr. Charles Mok received his medical degree from Chicago College of Osteopathic Medicine, Chicago, Illinois in 1989. He completed his medical residency at Mount Clemens General Hospital, Mt. Clemens, Michigan. He has worked with laser manufacturing companies to improve their technologies; he has performed clinical research studies and has taught physicians from numerous other states. His professionalism and personal attention to detail have contributed to the success of one of the first medical spas in Michigan.LinkedIn: https://www.linkedin.com/in/charles-mok-4a0432114/Instagram: https://www.instagram.com/alluremedicals/Website: https://www.alluremedical.com/YouTube: https://www.youtube.com/@AllureMedical Amazon Store: https://www.amazon.com/stores/Dr.-Charles-Mok/author/B0791M9FZQ?ref=ap_rdr&store_ref=ap_rdr&isDramIntegrated=true&shoppingPortalEnabled=true #Skincare #Rapamycin #Sirolimus #AntiAging #GlowingSkin #Longevity #Healthspan #SkinQuality #SkinCareRegimen #SkinMedication #Wellness #AestheticMedicine #LongLife #HealthPodcast

Welcome to episode 400 of Heart Doc VIP! Dr. Kahn discusses Zepbound injections for weight loss and sleep apnea, the impact of low-carb diets on cholesterol, coffee for longevity and memory benefits, red wine for heart health, Omega-3 fatty acids for heart failure prevention, and, finally, ultraprocessed (junk) foods and semen quality. The main topic is a reassessment of two potential longevity medications: rapamycin and metformin. Dr. Kahn reviews a new and important study on the impact of metformin on aging in older monkeys, providing detailed and impressive results regarding overall aging and brain health. Is it time to consider adding metformin to an anti-aging program?  This week's podcast is sponsored by Igennus Healthcare Nutrition, with the discount code DrKahn.

Subscribe to our channel: https://www.youtube.com/@optispan In this Q&A, Matt and Brian Kennedy cover a range of topics on caloric restriction, lifespan studies, interventions like rapamycin, and the importance of control groups in research. They critique the validity of certain longevity claims, discusses the complexities of aging mechanisms, and questions the effectiveness of supplements. The conversation also touches on dietary impacts, the role of exercise, and the significance of personalized medicine in aging research, emphasizing the need for careful interpretation of scientific data. 00:00:00 - Should Matt be skeptical of the 40% life extension figure for caloric restriction? 00:06:43 - Can calorie restriction be combined with other interventions like Rapamycin or Senolytics? 00:11:30 - Does metformin or berberine have significant effects on longevity? 00:14:51 - Is pea protein powder a good dietary choice for a complete protein? 00:17:33 - What are the best ways to increase VO2 max? 00:20:12 - Longevity Fads? 00:22:45 - How does cold exposure affect inflammation? 00:26:05 - How does NAD+ supplementation compare to NMN for longevity? 00:29:11 - What role does sleep quality play in overall lifespan? 00:32:00 - Can mindfulness or meditation improve biomarkers related to aging? 00:35:22 - Is there evidence that probiotics can extend lifespan? 00:38:45 - How does alcohol consumption affect aging and longevity? 00:41:10 - What are the best supplements for improving cognitive health with age? 00:45:00 - Are there specific dietary patterns proven to slow biological aging? 00:48:25 - How effective is Rapamycin when started later in life? 00:52:10 - Can exercise offset the negative effects of a poor diet? 00:55:34 - Is there a link between gut health and lifespan? 00:58:20 - What are the biggest misconceptions about anti-aging interventions? 01:06:33 - Do you track fiber intake? 01:07:45 - What's the common misconception about mTOR? 01:09:33 - Are there ongoing studies comparing rapamycin to other mTOR inhibitors in terms of safety and effect? 01:11:48 - Favorite band? 01:11:52 - How can a non-scientifically trained person tell good science from bad? Producers: Tara Mei, Nicholas Arapis Video Editor: Jacob Keliikoa DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices. More places to find us: Twitter: https://twitter.com/optispanpodcast Twitter: https://twitter.com/optispan Twitter: https://twitter.com/mkaeberlein Linkedin: https://www.linkedin.com/company/optispan Instagram: https://www.instagram.com/optispanpodcast/ TikTok: https://www.tiktok.com/@optispan https://www.optispan.life/

TARGET IV International Multicenter Randomized Assessment of the Firehawk® Rapamycin Eluting Coronary Stent System

There are a variety of area offering away to diversify in the crypto asset class which includes not only bitcoin but also other cryptocurrencies, crypto companies, crypto funds, and ETFs. And while cancer deaths are declining, the number of cancer cases, particularly among adults under 50, is rising, especially for breast and colorectal cancer. Behavior changes, including unhealthy consumption habits, can prevent up to 40% of cancer cases, with a positive attitude also contributing to improved health and longevity. #CryptoInvesting, #Bitcoin, #Diversification, #CryptoPortfolio, #Blockchain, #CryptoAssets, #ETFInvesting, #CryptoFunds, #RicEdelman, #DigitalAssets #CancerPrevention, #HealthyLiving, #AlcoholAndCancer, #BreastCancer, #ColorectalCancer, #PositiveMentalAttitude, #Longevity, #HealthyHabits, #Rapamycin, #CancerAwareness ----- Stay Connected on Ric's Distribution List https://bit.ly/ric_edelman Ask Ric: https://www.thetayf.com/pages/ask-ric  -----   Links from today's show:   1/15 Webinar - Your Crypto Questions Answered: https://dacfp.com/events/your-crypto-questions-answered 12/10 Webinar Replay - The Retirement Revolution: ETF Solutions for Modern Retirement Planning: https://www.thetayf.com/pages/the-retirement-revolution-etf-solutions-for-modern-retirement-planning 12/9 Webinar Replay - What the Election Results Mean for Crypto:  https://dacfp.com/events/what-the-election-results-mean-for-crypto 2/24-2/26 Wealth Management Convergence-2025: https://www.thetayf.com/pages/convergence 11/13 Webinar Replay - An Innovative Way to Generate Income in a World of Declining Rates: https://www.thetayf.com/pages/november-13-2024-an-innovative-way-to-generate-income 10/9 Webinar Replay - Crypto for RIAs: Yield, Staking, Lending and Custody. What's beyond the ETFs? https://dacfp.com/events/crypto-for-rias-yield-staking-lending-and-custody-whats-beyond-the-etfs/ -----   Follow Ric on social media:   Facebook: https://www.facebook.com/RicEdelman Instagram: https://www.instagram.com/ric_edelman/ LinkedIn: https://www.linkedin.com/in/ricedelman/ X: https://twitter.com/ricedelman YouTube: https://www.youtube.com/@RicEdelman -----   Brought to you by:   Invesco QQQ: https://www.invesco.com/qqq-etf/en/home.html State Street Global Advisors: https://www.ssga.com/us/en/intermediary/etfs/capabilities/spdr-core-equity-etfs/spy-sp-500/cornerstones Schwab: https://www.schwab.com/ TAYF Disclosure page: https://www.thetayf.com/pages/sponsorship-disclosure-fee

Self-experimentation with the anti-aging drug rapamycin continues to be strongly discouraged.

Rapamycin appears to be a universal anti-aging drug, extending the lifespan of all animals tested to date; it's the only known drug to do so.

“Nutrition cannot be underestimated – it is the medicine we take everyday,” says Robert Lufkin, M.D.  Robert Lufkin, physician, medical school professor, and New York Times bestselling author, joins us to discuss everything from lifestyle modifications to reversing chronic diseases and how to reimagine the current healthcare system, plus:  - The obesity lie (~2:02) - The calorie model (~3:10) - The impact of ultra-processed foods (~6:47) - 3 nutritional guidelines (~11:53) - Reversing chronic diseases (~15:40) - The importance of nutrition (~22:13) - Pharmaceutical use with lifestyle modifications (~26:18) - Rapamycin and mTOR (~28:15) - When to start making changes (~35:54) - The future of longevity (~38:20) - The importance of mindset (~40:55) - Final message of hope (~41:40) Referenced in the episode:  - Connect with Robert Lufkin online (https://www.robertlufkinmd.com/) - Follow him on X, Instagram, and LinkedIn (@robertlufkinmd)  - Pick up his book, Lies I Taught In Medical School  - Read the first chapter of his book (https://www.robertlufkinmd.com/lies/) - Research on rapamycin for longevity (doi: 10.1007/s11357-020-00274-1)  - Visit shop.mindbodygreen.com/coffee20 to get 20% off your first order.  We hope you enjoy this episode, and feel free to watch the full video on YouTube! Whether it's an article or podcast, we want to know what we can do to help here at mindbodygreen. Let us know at: podcast@mindbodygreen.com. Learn more about your ad choices. Visit megaphone.fm/adchoices

We are in the era of "longevity science". Are there medications that can extend your life and stop you from aging? Rapamycin, canagliflozin, dapagliflozin, empagliflozin, dasatinib, quercentin, ozempic, wegovy or flavanols. These are all medications that are being studied in rats, mice, worms, and some primates and it extends life in all of them. It decreases disease - and humans are starting to take them - is this the insane ways that we will live to 150? Some scientists think this is happening right nowSTUDYTIME: the new drugs that will make you live to 150WDWLTW:a new nasal spray to stop you from getting the flu or coldschickadee hybrids are blowing my mind Hosted on Acast. See acast.com/privacy for more information.

I'm excited to be joining Dr. Lorne Brown on the Conscious Fertility Podcast to dive into a fascinating topic—Rapamycin. While it's started to be used as an anti-aging drug, I've been exploring its potential for reproductive health, especially in improving fertility and delaying menopause.  In this episode, I share my personal experience taking Rapamycin, including how it's affected my skin, menstrual cycles, and overall health. We'll also get into the science behind it and how it may be beneficial for women going through menopause or undergoing fertility treatments like IVF.  While I'm passionate about this topic, I want to emphasize that this is not medical advice—always consult your doctor before considering any new treatments. I also share how my alcohol-free lifestyle supports my approach to healthy aging and fertility. Key points covered include: How Rapamycin may help delay menopause, reverse its effects, and support fertility treatments. Some of the potential side effects, like cystic acne and mouth sores. Why I started using and prescribing Rapamycin for longevity and helping women improve fertility later in life. My personal experience with Rapamycin, including smoother skin, regular cycles, and no gray hair at 48. The importance of consulting your doctor before trying Rapamycin, as this podcast is informational and not meant as medical advice. Get the full show notes on Dr. Aimee's website. Listen to Dr. Aimee interview Dr. Lorne Brown about about conscious fertility and psychoneuroimmunology. You can find Dr. Brown here Conscious Fertility Podcast Dr. Lorne Brown On Instagram Dr. Aimee's list of supplements Do you have questions about IVF?Click here to join Dr. Aimee for The IVF Class where Dr. Aimee will explain IVF and there will be time to ask her your questions live on Zoom.   Subscribe to my YouTube channel for more fertility tips! Subscribe to the newsletter to get updates   Dr. Aimee Eyvazzadeh is one of America's most well known fertility doctors. Her success rate at baby-making is what gives future parents hope when all hope is lost. She pioneered the TUSHY Method and BALLS Method to decrease your time to pregnancy. Learn more about the TUSHY Method and find a wealth of fertility resources at www.draimee.org.

David Fajgenbaum was in his third year of medical school when he was diagnosed with a rare and life-threatening disease that began shutting down his organs, bringing him perilously close to death. Although he survived the initial episode, he faced four additional relapses, each pushing him to the brink of death. In this episode, we speak with David about his relentless journey to discover the treatment that ultimately put his disease into remission. We also explore how his personal battle inspired the creation of a groundbreaking approach to help others suffering from rare diseases.Follow us on LinkedIn, X, Facebook and Instagram. Visit us at https://www.bio.org/

Today's show is brought to you by MYOXCIENCE Nutrition. In this episode Matt Kaeberlein, PhD, CEO of Optispan, discusses the significance of enhancing health span through interventions like rapamycin and highlights the role of senescent cells in chronic inflammation and age-related diseases. Crush your workouts with the Creatine+ Electrolyte Combo by MYOXCIENCE: https://bit.ly/Electrolyte-Stix-Jar *Save with code podcast at checkout Link to show notes: https://bit.ly/4gdmxES Key Takeaways:  02:44 Pillars of health: eat, sleep, move, connect. 10:30 Eating protein and exercise can turn up mTOR. 15:20 High dietary protein and resistance training preserves muscle while aging. 19:20 Longevity research is underfunded. 25:10 Obesity was rare 50 years ago. 26:25 Fasting, and time restricting eating may not increase longevity. 30:45 Smoking, sedentary life, alcohol consumption and obesity shorten lifespan. 34:40 Resveratrol is not a longevity drug. 36:45 Spermidine is an autophagy booster. 38:10 Alpha ketoglutarate, urolithin A, and NAD precursors, may increase lifespan. 42:45 Acarbose, SGLT-2 inhibitors, and estrogens can increase lifespan. 44:45 Metformin does not corelate to reduced all-cause mortality. 47:30 NAD is a co-factor required for thousands of metabolic reactions. 52:55 Some epigenetic signatures are predictive of future health outcomes. 54:17 Facial imaging using AI can predict future health outcomes. 58:17 Dunedin Pace measures the rate of aging. 59:40 Optispan looks at epigenetics, blood glycan, and immune resilience/aging. 01:04:00 Senescent cells are cells that do not do their job and refuse to die. 01:07:50 Rapamycin impacts senescent cells, autoimmunity, and inflammation.    

In this episode, Dr. Anthony Youn, America's holistic plastic surgeon, converses with Dr. Emily Levin, a dermatologist from Metro Detroit. They explore various topics in cosmetic medicine and dermatology, including the controversial use of "salmon sperm facials" by Kim Kardashian, Steve-O's comedic plans for breast augmentation, and the dynamics between plastic surgeons and dermatologists. They also discuss the ethical considerations of body modifications, the impact of online reviews on medical practices, and the potential anti-aging benefits of rapamycin. The episode emphasizes the importance of collaboration, patient education, and ethical standards in cosmetic medicine. Links and Resources: Northwest Dermatology Northwest Dermatology Instagram Where can you find more information about how to autojuvenate your skin to a younger you? Check out my new book, Younger For Life! It's available at https://autojuvenation.com, and if you buy it now, you will receive over $100 in FREE gifts, including a $30 gift certificate for my online store younbeauty.com! Check out Dr. Youn's skincare products and nutritional supplements - younbeauty.com Download his FREE eGuide: "What to Eat to Look Younger" - dryoun.com/eat-look-younger Follow Dr. Youn on Instagram - @tonyyounmd Follow Dr. Youn on YouTube - youtube.com/tonyyounmd Follow Dr. Youn on TikTok - @doctoryoun Follow Dr. Youn on Facebook - @dryoun

In this episode, my guest is Dr. Peter Attia, M.D., a Stanford and Johns Hopkins School of Medicine-trained physician expert in improving human healthspan and lifespan. Dr. Attia is also the host of The Drive podcast and author of the best-selling book Outlive.  We discuss the NAD pathway in human cells and its possible links to aging and health. We evaluate how supplementation can augment molecules in the NAD pathway; we compare NAD, NMN, and NR, different routes of administration, their safety, and bioavailability. Then, we discuss the broader research and clinical literature on longevity to decide if supplementation with NAD, NR, NMN, rapamycin, or resveratrol can indeed extend lifespan.  Finally, we each describe our supplement regimens and compare the role of supplementation to behaviors such as sleep, nutrition, and exercise for longevity. We also discuss whether tests of biological age are true indicators of aging and whether normal radiation levels increase cancer risk.  Listeners of this episode will learn if supplements purported to improve lifespan show any efficacy and the behaviors and other factors that can prevent disease and extend lifespan. Access the full show notes for this episode at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman LMNT: https://drinklmnt.com/huberman Levels: https://levels.link/huberman Eight Sleep: https://eightsleep.com/huberman Timestamps 00:00:00 Dr. Peter Attia, NAD Pathway 00:02:31 Sponsors: LMNT, Levels & Eight Sleep 00:06:38 Categories of Longevity Approaches 00:17:22 Peter's Supplements; Rapamycin & Research Data 00:25:01 NAD Pathway: Energy & DNA Repair; Knock-Out & Knock-In, Klotho 00:30:35 Sponsor: AG1 00:32:25 Yeast, Sirtuins, Caloric Restriction & Lifespan 00:38:56 Sirtuins, Transgenic Mice, Gender & Lifespan 00:43:42 DNA Repair, Sirtuins, Cancer; Resveratrol 00:53:31 Perform with Dr. Andy Galpin Podcast 00:54:18 NAD & NADH, Reactive Oxygen Species (ROS), Mitochondrial Health 01:02:17 NAD vs NR vs NMN Supplementation; IV & Oral Routes 01:11:33 NR vs. NMN, Doses, Side Effects; Interventions Testing Program 01:17:43 Fatty Liver Disease & NR; NMN & Glucose; Clinical Significance 01:25:17 Safety & FDA, NMN & NR Supplementation; Skin Cancer Benefits 01:30:38 Longevity, NR & NMN Supplementation, Inflammation 01:41:00 Rapamycin & Immune Function 01:44:37 Biological Aging Tests, Chronologic & Biologic Age; Vigor  01:55:24 Radiation & Cancer Risk 01:58:12 Tool: Self-Care in 50s-70s & Aging; Energy Decline 02:07:12 Tool: Exercise Timing & Energy Levels 02:11:22 Peter's Supplements 02:18:46 Andrew's Supplements 02:24:34 Tool: Supplement Use vs. Critical Behaviors; Titanic Analogy  02:26:52 NAD Pathway Supplementation for Longevity? 02:28:52 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, YouTube Feedback, Social Media, Neural Network Newsletter Disclaimer

Dr. Zinkov discusses ways to use peptides therapeutically to improve tissue rejuvenation and repair, promote longevity, enhance muscle growth, and boost mood, vitality, and libido. She discusses the benefits and risks, sourcing, dosages, cycling, administration routes, and how they work in combination w/ hormone optimization. Support your Workout Sessions and Healthy Hydration with the Electrolyte + Creatine Combo by MYOXCIENCE: https://bit.ly/electrolyte-stix *Save 12% with code podcast at checkout Link to Video, Show Notes and Research: https://bit.ly/4bcEks6 Show Notes: 02:45 Peptides stimulate your endogenous production of growth hormone. 03:10 Sermorelin does not increase growth hormone beyond super physiologic levels. 04:35 Peptides can improve hormone health, longevity, reverse aging-related processes of inflammation and injury recovery. 08:45 Growth hormone improves cell function. 11:05 Sermorelin stimulates growth hormone secretion for about 12 minutes. 12:30 Growth hormone peaks are nighttime and post-workout. 14:30 Symptoms of suboptimal growth hormone. 15:45 IGF-1 is a biproduct of growth hormone breakdown. 18:30 Additional strategies. 22:05 Poor diet and lifestyle choices reduce growth hormone. 25:10 Women in their teens and 20s may have suboptimal production of hormones. 30:30 Progesterone receptors can be stimulated with herbal treatments. 31:30 Xenoestrogens cause more disruptive receptor stimulation. 33:15 Obesity is one of the biggest risk factors for breast cancer. 34:30 Growth hormone stimulates collagen production. 37:15 Low dose Rapamycin slows the aging process. 40:30 Methylene Blue has been used as a nootropic. 43:55 Nicotine directly and quickly stimulates the vagal nerve. 53:00 Growth hormone does not cause cancer.      

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this special edition celebrating 300 episodes of The Drive, Peter discusses a variety of popular topics and health interventions and classifies them based on their level of evidence and relevance using the following categories: proven, promising, fuzzy, noise, and nonsense. Peter first delves into the topic of geroprotective molecules, covering rapamycin, metformin, NAD and its precursors, and resveratrol. Next, he explores the significance of metrics like VO2 max and muscle mass, as well as emerging concepts like blood flow restriction and stem cells. The conversation extends to nutrition, addressing questions surrounding long-term fasting, sugar consumption, sugar substitutes, and the contentious role of red meat in cancer. Peter not only provides his current stance on each topic—most of which have been covered in great detail in the previous 300 episodes—but also reflects on how his opinion may have evolved over the years. We discuss: Defining the categories of “proven, promising, fuzzy, noise, and nonsense” [3:15]; Rapamycin [9:30]; Metformin [17:00]; NAD and its precursors [24:30]; Resveratrol [32:45]; The importance of VO2 max, muscle mass, and muscular strength for lifespan [38:15]; Blood flow restriction (BFR) training [44:00]; Using stem cells to treat osteoarthritis or injury [51:30]; Fasting as a tool for longevity (and why Peter stopped his fasting protocol) [55:45]; The energy balance theory [1:06:30]; The idea that sugar is poison [1:12:00]; The idea that sugar substitutes are dangerous [1:22:15]; The debate on red meat and cancer [1:28:45]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube