Podcasts about rapamycin

I del 2 med Professor Maria Strömme riktar vi fokuset mot vetenskapen bakom ett längre, friskare och starkare liv. Varför har evolutionen egentligen slutat bry sig om oss efter 30? Kan träning fungera som ett läkemedel? Och finns det redan idag behandlingar som skulle kunna förlänga människans livslängd avsevärt?Maria förklarar hur högintensiv träning stimulerar hjärnans nybildning av nervceller, varför lågintensiv träning bygger kroppens energifabriker och hur periodisk fasta kan aktivera kroppens egna städprocesser. Vi pratar också om mTOR – ett av kroppens viktigaste system för åldrande – och det omtalade läkemedlet Rapamycin som i studier visat stor potential för ökad livslängd.Dessutom avslöjar Maria hur blodsockret påverkar våra gener, varför fibrer kan vara ett av de enklaste biohacken för bättre hälsa och hur missförstånd kring östrogenbehandling har påverkat miljontals kvinnor i klimakteriet. Hon riktar även kritik mot dagens sjukvård och menar att vi måste gå från att behandla sjukdomar till att förebygga dem långt innan de uppstår.Vi pratar också om varför blodprover inte alltid berättar hela sanningen, hur vagusnerven kan hjälpa oss att hantera stress, varför ensamhet är en av våra största hälsorisker och hur en varierad kost med många olika växter kan stärka både tarmflora och immunförsvar.Ett fullmatat avsnitt om longevity, biohacking och framtidens hälsa – med konkreta råd som kan hjälpa dig att må bättre redan idag.Läs mer om Maria här Lyssna på första avsnittet med Maria härLäs mer om Framgångsakademin här.Ta del av Framgångsakademins kurser.Beställ "Mitt Framgångsår".Följ Alexander Pärleros på Instagram.Följ Alexander Pärleros på Tiktok.Bästa tipsen från avsnittet i Nyhetsbrevet. Hosted on Acast. See acast.com/privacy for more information.

I del 2 med Professor Maria Strömme riktar vi fokuset mot vetenskapen bakom ett längre, friskare och starkare liv. Varför har evolutionen egentligen slutat bry sig om oss efter 30? Kan träning fungera som ett läkemedel? Och finns det redan idag behandlingar som skulle kunna förlänga människans livslängd avsevärt?Maria förklarar hur högintensiv träning stimulerar hjärnans nybildning av nervceller, varför lågintensiv träning bygger kroppens energifabriker och hur periodisk fasta kan aktivera kroppens egna städprocesser. Vi pratar också om mTOR – ett av kroppens viktigaste system för åldrande – och det omtalade läkemedlet Rapamycin som i studier visat stor potential för ökad livslängd.Dessutom avslöjar Maria hur blodsockret påverkar våra gener, varför fibrer kan vara ett av de enklaste biohacken för bättre hälsa och hur missförstånd kring östrogenbehandling har påverkat miljontals kvinnor i klimakteriet. Hon riktar även kritik mot dagens sjukvård och menar att vi måste gå från att behandla sjukdomar till att förebygga dem långt innan de uppstår.Vi pratar också om varför blodprover inte alltid berättar hela sanningen, hur vagusnerven kan hjälpa oss att hantera stress, varför ensamhet är en av våra största hälsorisker och hur en varierad kost med många olika växter kan stärka både tarmflora och immunförsvar.Ett fullmatat avsnitt om longevity, biohacking och framtidens hälsa – med konkreta råd som kan hjälpa dig att må bättre redan idag.Läs mer om Maria här Lyssna på första avsnittet med Maria härLäs mer om Framgångsakademin här.Ta del av Framgångsakademins kurser.Beställ "Mitt Framgångsår".Följ Alexander Pärleros på Instagram.Följ Alexander Pärleros på Tiktok.Bästa tipsen från avsnittet i Nyhetsbrevet. Hosted on Acast. See acast.com/privacy for more information.

Rapamycin may be able to help older adults live longer, healthier lives. Studies of mice suggest the drug may even reverse hardening of the arteries. Researchers at UT Health San Antonio have launched a clinical trial to see if the drug can restore the biological activity of older adults to levels more typical of younger people, and, if so, how much does it take to do it?

Finally, it's here. Dr Brad Stanfield 2026 Study on rapamycin.A drug that consistently extends lifespan in lab mice was just tested in humans. Combined with exercise. In people over 65.Did it work?The answer surprised even the researchers running the study.What did they find? Did rapamycin fail? If so, why? And what's my analysis of the result?

00:00 Einführung: Sarcopenie als Problem 01:24 Der Müll wird nicht mehr abgeholt 04:08 Wenn der Muskel vernarbt 06:26 Stammzellen: Ursache oder Folge? 08:01 Das Nervensystem – der vergessene Faktor 09:13 Hormone – komplizierter als gedacht 10:41 Was das alles bedeutet 12:22 Outro ________ Patreon mit exklusive Folgen: https://www.patreon.com/thecoachcoachcorner Mein Instagram: https://instagram.com/hybridathlet Individuelle Coachings: http://www.become-fit.de Meine Bücher: https://www.amazon.de/kindle-dbs/entity/author/B01MG4H6WB Die Untersuchung: https://pubmed.ncbi.nlm.nih.gov/41837678/ In der Podcast-Folge von KWMIB geht es um Sarkopenie, also den altersbedingten Verlust von Muskelmasse und Kraft. Dabei wird deutlich gemacht, dass es sich nicht um ein Randproblem handelt, sondern um einen Prozess, der nahezu jeden Menschen im Alter betrifft, wenn nicht aktiv gegengesteuert wird. Da bislang kein zugelassenes Medikament existiert, richtet sich der Blick auf die biologischen Ursachen und auf praktikable Gegenmaßnahmen. Im Mittelpunkt steht zunächst der gestörte Muskelstoffwechsel im Alter. Ein zentrales Problem ist das dauerhaft überaktive Signalprotein mTORC1. Obwohl es grundsätzlich am Muskelaufbau beteiligt ist, verhindert seine chronische Aktivierung wichtige Selbstreinigungsprozesse der Zelle, insbesondere die Autophagie. Die Folge ist, dass sich beschädigte Proteine und Zellbestandteile ansammeln. Gleichzeitig verändert sich die extrazelluläre Matrix des Muskels: Das Gewebe wird steifer, lagert mehr Kollagen ein und vernarbt zunehmend. Diese Fibrose verschlechtert nicht nur die Muskelkontraktion, sondern beeinträchtigt auch die Funktion von Stammzellen, die für Reparatur und Regeneration wichtig wären. Hinzu kommt, dass mit zunehmendem Alter motorische Nervenzellen verloren gehen. Dadurch werden Muskelfasern schlechter angesteuert, was zu Atrophie führt. Auch die Muskelstammzellen selbst verlieren an Funktionsfähigkeit, weil sie im Alter oft zu früh aktiviert werden und bei echtem Reparaturbedarf bereits erschöpft sind. Zusätzlich spielt ein gestörter Aminosäurestoffwechsel eine Rolle: Aminosäuren werden nicht mehr effizient verarbeitet, was das ohnehin überaktive mTORC1-System weiter antreibt. Bei den Hormonen wird zwischen Männern und Frauen unterschieden. Testosteron spielt für Männer eine wichtige Rolle, bei Frauen ist eher Östrogen relevant. Allerdings zeigen Hormonersatztherapien nicht automatisch eine Verbesserung der alltagsrelevanten Muskelfunktion. Als wirksamste Strategie gegen Sarkopenie nennt der Podcast weiterhin klassisches Krafttraining kombiniert mit einer ausreichenden Proteinzufuhr von etwa 1,2 bis 1,6 Gramm pro Kilogramm Körpergewicht. Ergänzend werden Kreatin, Urolithin A und experimentell auch Rapamycin diskutiert. Das Fazit: Sarkopenie ist komplex, lässt sich aber durch Training und Ernährung deutlich bremsen.

More on “eat the rainbow” . . . or notMedical breakthroughs that we don't really needCan you discuss the order of eating macronutrients and its impact on blood glucose?What about the impact of apple cider vinegar on blood sugar?

What if an AI could run centuries of aging experiments in a year? Dr. Daniel Ives, CEO of Shift Bioscience, explains how his team used a virtual cell to discover SB000 — a single gene that matches Yamanaka factor rejuvenation without cancer risk.CHAPTERS:00:00 — Centuries of experiments in a year02:03 — Daniel's journey: physics → Aubrey de Grey10:08 — The epigenetic clock breakthrough12:09 — The 13 mitochondrial genes20:09 — Yamanaka factors (OSKM) explained22:10 — Partial reprogramming: the weekend analogy24:11 — The cancer risk problem26:11 — AI virtual cell: how it works32:12 — AI-driven dark labs40:16 — Single-gene interventions42:17 — Shift's discovery: genes that reverse aging50:19 — Animal testing begins62:20 — Hearing loss: the unexpected aging connection66:21 — Rapamycin reverses hearing loss in animals78:25 — N=1 medicine and wearables84:26 — ClosingREFERENCES:Shift Bioscience: shiftbioscience.comPartial Reprogramming (Nature Comms, 2024): NatureEpigenetic Clock (Frontiers in Aging, 2024): FrontiersGUEST: Dr. Daniel Ives, PhD — CEO, Shift Bioscience, Cambridge UKHOST: Dr. Robert Lufkin MD | robertlufkinmd.com⭐ Enjoying the show? Please leave a 5-star review on Apple Podcasts — it takes 30 seconds and helps more people discover the science of health and longevity. Thank you!New episodes every Tuesday & Thursday. Subscribe so you don't miss one.Continue this conversation on Substack: https://robertlufkinmd.substack.comLies I Taught In Medical School — Free sample chapter: https://www.robertlufkinmd.com/lies/Web: https://www.robertlufkinmd.comYouTube: https://www.youtube.com/robertlufkinmdX: https://x.com/robertlufkinmdInstagram: https://www.instagram.com/robertlufkinmd/TikTok: https://www.tiktok.com/@robertlufkinLinkedIn: https://www.linkedin.com/in/robertlufkinmd/

Brian Kennedy is one of the world's leading researchers studying the biology of aging.In this conversation, we break down what longevity science actually shows about extending healthy lifespan and the everyday habits that appear to influence how we age.Dr. Brian shares insights from decades of aging research, explaining how scientists study longevity, how interventions like rapamycin and biological age testing are evaluated, and how lifestyle factors such as exercise, nutrition, fasting, and sleep continue to shape the foundation of long-term health.Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women's health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you'll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.https://kayla-barnes-lentz.circle.so/checkout/become-a-member5 key longevity habits discussed in this episode:- Exercise and physical activity- Nutrition and metabolic health- Energy balance and fasting- Sleep and recovery- Longevity interventions and emerging therapiesTogether, these factors form the foundation researchers believe will have the greatest impact on healthspan as longevity science continues to evolve.Connect with Kayla:Instagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter:https://x.com/femalelongevityWebsite:https://www.kaylabarnes.com/Spotify:https://open.spotify.com/show/4OLWWn22...Apple: https://podcasts.apple.com/us/podcast...Follow Her Female Protocol: https://www.protocol.kaylabarnes.comLearn more about Dr. Brian Kennedy:LinkedIn: https://www.linkedin.com/in/brian-kennedy-69777318/Website: https://medicine.nus.edu.sg/trp/healthy-longevity/

Send us Fan MailMost pet owners trust that regular vet visits, decent food, and a joint supplement are enough. Dr. Kevin Toman spent 35 years practicing that model. He doesn't believe it anymore.After four decades in clinical medicine, a personal MGUS diagnosis that pushed him toward integrative care, and a growing awareness of how poorly the profession was serving aging pets, he rebuilt his practice entirely around longevity. He now runs one of the only concierge veterinary practices in the country focused on extending healthspan, not just managing disease.If you don't have a pet, stay with this one. The conversation keeps landing back in the same place: the principles driving longevity in dogs and cats are the same ones driving it in humans. Rapamycin, caloric restriction, early cancer diagnostics, dental inflammation as a systemic disease driver, the failure of reactive medicine. Dr. Toman is applying an identical framework to a different patient population, and in some cases the data is cleaner because the studies are easier to run.Dr. Kevin White sits down with Dr. Toman to cover rapamycin's role in preventing and treating cancer in dogs and cats, why he's using it preventively in asymptomatic patients, why glucosamine and chondroitin don't work and what the research actually supports, how breed-specific risk changes everything about how a patient should be managed, the cancer navigation crisis facing pet owners in rural areas, and where early cancer diagnostics are heading for both species."The relationships and the holistic care that are so important to lifestyle and longevity have disappeared from the veterinary lexicon."This one covers more ground than most pet health conversations get anywhere near.Find more from Dr. Toman at helpingpetslivelonger.com and freevetcall.comAnd follow The Daily Apple and leave a review to help more people find the show. Instagram: @KevinWhiteMD YouTube: @KevinWhiteMDwww.primehealthassociates.com  Prime Health Associates

Bérénice Benayoun, PhD, explains why ovarian aging may be one of the earliest and most important drivers of female aging, influencing the brain, immune system, metabolism, and long-term disease risk far beyond reproduction. She breaks down what we actually know so far, including DNA damage, mitochondrial dysfunction, fibrosis, hormonal signaling, and why the ovary appears to age faster than other tissues.We also get into one of the most surprising findings in the field right now: a brand new study from her lab found that post-reproductive gut microbiota unexpectedly improved ovarian reserve and lowered inflammatory signals in young mice, raising a completely new set of questions about the gut-ovary connection and what may eventually be possible for ovarian health.Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women's health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you'll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.https://kayla-barnes-lentz.circle.so/female-longevity-communityIn this conversation:-Why the ovary may be the fastest aging organ in the female body-Why menopause is a healthspan issue, not just a fertility issue-DNA damage, mitochondria, fibrosis, and the hallmarks of ovarian aging-The new microbiome finding that surprised even the researchers-Why later menopause predicts longer and healthier life-Rapamycin, hormone therapy, and what may actually helpIf you're already paying attention to food, sleep, and overall health, cleaning products are another place where exposure adds up quickly. Branch Basics is a simple way to clean your home with fewer unnecessary ingredients and less clutter under the sink.Check them out: https://branchbasics.com/KAYLA15For 15% off use code: KAYLA15Connect with Kayla:Instagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter:https://x.com/femalelongevityWebsite:https://www.kaylabarnes.com/Spotify:https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ?si=8e91b3c9e0ce4054Apple:https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227Follow Her Female Protocol: https://www.protocol.kaylabarnes.comLearn more about Bérénice Benayoun:LinkedIn: https://www.linkedin.com/in/b%C3%A9r%C3%A9nice-benayoun-a374a74b/en/Website: https://gero.usc.edu/labs/benayounlab/Her New Study (Estropausal gut microbiota transplant improves measures of ovarian function in adult mice): https://pubmed.ncbi.nlm.nih.gov/41776310/

What if you had more control over your brain's future than you think? Dr. Tommy Wood, neuroscientist, Associate Professor of Pediatrics at the University of Washington, and head of science for motorsport at Hintsa Performance, joins Dr. Matt Kaeberlein to discuss his new book, The Stimulated Mind. From the science of neuroplasticity to the real drivers of dementia prevention, this episode is packed with evidence-based, actionable insight.Timestamps:0:00 — Introduction: Brain fog, burnout & why our brains feel under strain1:42 — Age-specific dementia incidence has been declining — why no one talks about it2:05 — Why Dr. Wood wrote The Stimulated Mind4:59 — Dr. Wood's background: Cambridge, Oxford, Oslo, and UW8:30 — How a PhD in neonatal brain injury led to elite athlete performance work11:20 — The Keto CTA Trial: ApoB, LDL, and plaque formation on a ketogenic diet15:50 — Can you still have metabolic dysfunction on a long-term keto diet?17:17 — What the keto trial actually found — and why the original results were retracted23:53 — Working with Formula One drivers: biomarkers, blood panels & performance29:51 — Magnesium: is everyone actually deficient?30:33 — The zinc-copper problem in athletes — and why B6 stacks up in their blood34:03 — Why elite athletes use fewer supplements than you'd expect35:19 — Sleep tracking with wearables: HRV, respiratory rate & what actually predicts performance39:53 — Why Dr. Wood wrote The Stimulated Mind (deeper dive)42:16 — Dementia: confluence of factors, individual trajectories & the Lancet projections44:23 — GLP-1s, metabolic disease & shifting dementia projections49:00 — The adult brain is NOT fixed: neuroplasticity across the lifespan52:44 — Is promoting neuroplasticity always beneficial? TMS and the "sledgehammer" problem57:02 — Exercise as a neuroplasticity tool: the 20–30 minute jog protocol58:26 — Arousal, the Yerkes-Dodson curve & how mistakes drive learning1:01:17 — Cold exposure, bright light & breathwork as arousal tools1:04:11 — Psilocybin and neuroplasticity: therapeutic promise vs. open questions1:06:39 — Can grief induce neuroplasticity? An unexpected connection1:08:03 — The 3S Model: Stimulus, Supply & Support for brain health1:15:26 — Education, cognitively stimulating jobs & making up for early deficits1:17:49 — The ACTIVE Study: the brain training game with 20-year dementia data1:23:31 — Video games, exercise & what's actually building cognitive reserve1:25:03 — Supply: why cardiovascular and metabolic health are critical for the brain1:26:29 — Key nutrients for brain health: omega-3s, B vitamins, vitamin D & iron1:27:14 — The Vitacog study: why omega-3 index and homocysteine must be optimized together1:29:59 — PDE5 inhibitors (Viagra/Cialis) and dementia risk — what the data says1:32:30 — Cognitive supplements: what actually has evidence (and what doesn't)1:35:41 — Rapamycin and cognitive function: cerebral blood flow & immune resilience1:38:43 — The best exercise for your brain: Zone 2, HIIT, resistance training & sport1:44:34 — Nutrition strategy for cognitive aging: whole foods, polyphenols & berries1:47:46 — Support: sleep, trophic factors & hormonal health1:48:31 — Testosterone, estrogen & menopause: what hormone therapy can and can't do for the brain1:52:21 — Air quality, chronic stress & environmental exposures as dementia risk factors1:54:19 — Chronic stress as "overtraining" for the brain

On today's episode of The Wholesome Fertility Podcast, Michelle sits down with Aimee Raupp (@aimeeraupp) to explore the latest breakthroughs in fertility science and ovarian rejuvenation. From PRP (platelet-rich plasma) therapy and rapamycin to senolytics, peptides, and low-dose naltrexone (LDN), this conversation dives into emerging tools that may support egg quality, ovarian function, and fertility after 35. They also challenge long-standing scientific dogma around ovarian aging and discuss whether women are truly born with all the eggs they'll ever have. If you're navigating diminished ovarian reserve, PCOS, endometriosis, insulin resistance, or age-related fertility concerns, this episode offers cutting-edge insights and practical hope grounded in evolving research. Key Takeaways: PRP ovarian rejuvenation may improve ovarian function and support natural conception in some women. Emerging research questions the belief that women are born with all their eggs, opening new conversations about ovarian aging and regeneration. Rapamycin and senolytics (like fisetin) are being studied for their potential role in delaying ovarian aging and reducing inflammation. Peptide therapy may support hormonal balance, egg quality, insulin sensitivity, and conditions like PCOS. Low Dose Naltrexone (LDN) may help regulate immune function, reduce inflammation, and support fertility outcomes in certain cases. Guest Bio: Aimee Raupp (@aimeeraupp) , MS, LAc, is a leading fertility expert, licensed acupuncturist, women's health advocate, and bestselling author dedicated to helping women improve egg quality, balance hormones, and optimize their ability to get and stay pregnant, naturally or with IVF. She is the author of Chill Out & Get Healthy, Yes, You Can Get Pregnant, Body Belief, and The Egg Quality Diet, a clinically proven 100-day fertility program designed to reduce inflammation and enhance reproductive health. With over 20 years of clinical experience, Aimee works with clients worldwide through virtual fertility coaching and treats patients at her New York and Connecticut clinics. She is the founder of Aimee Raupp Beauty and co-founder of Rejoova, a science-backed fertility supplement company supporting egg and sperm health. Her work has been featured on The View and in Glamour, Allure, Shape, Well + Good, MindBodyGreen, and GOOP, with endorsements from leaders in wellness and personal development. Connect with Aimee Raupp: Visit her websiteFollow her on Instagram Follow her on Tiktok Learn more Healthgevity here For more information on working with Aimee and her team of fertility coaches and acupuncturists, email info@aimeeraupp.com Disclaimer: The information shared on this podcast is for educational and informational purposes only and is not intended as medical advice. Please consult with your healthcare provider before making any changes to your health or fertility care. Ready to discover what your body needs most on your fertility journey? Take the personalized quiz inside The Wholesome Fertility Journey and get tailored resources to meet you exactly where you are:  https://www.michelleoravitz.com/the-wholesome-fertility-journey For more about my work and offerings, visit: www.michelleoravitz.com Curious about ancient wisdom for fertility? Grab my book The Way of Fertility: https://www.michelleoravitz.com/thewayoffertility Join the Wholesome Fertility Facebook Group for free resources & community support: https://www.facebook.com/groups/2149554308396504/ Connect with me on social: Instagram: @thewholesomelotusfertilityFacebook: The Wholesome Lotus  

Matters Microbial #125: Antibiotics, Streptomyces and Evolution March 15, 2026 Today Professor Paul Hoskisson, Royal Academy of Engineering Research Chair in Engineering Biology at the University of Strathclyde joins the Quality Quorum to discuss his research group's adventures studying how the bacterium Streptomyces develops, produces antibiotics, and evolves! Host: Mark O. Martin Guest: Paul Hoskisson Subscribe: Apple Podcasts, Spotify Become a patron of Matters Microbial! Links for this episode Here is a biographical sketch of the impact of Carl Woese on microbiology. Here is a fine (if dated) video describing Woese's impact and work.  It's truly wonderful to hear Woese himself discuss his work and challenges. Yours truly wrote an essay on Carl Woese and undergraduate education. An article on geosmin and actinobacteria.  It may smell like soil, but it has other functions, like attracting springtails! An overview of the genus Streptomyces. A video showing the beauty of the life cycle of Streptomyces and various interactions. Linear genomes in bacteria. An overview of antibiotics. Selman Waksman and early antibiotics.  And a Nobel Prize! The remarkable Julian Davies and antibiotic function. Davies' concept of small molecules with functions:  the parvome. A wonderful collection of articles in honor of Julian Davies. The antibiotic resistance crisis that we all face.   Rapamycin and the organism that synthesizes that compound, which is an immunosuppressant helpful in organ transplantation. The concept of Biosynthetic Gene Clusters (BGC). Rich Lenski and the LTEE program to study evolution in bacteria. A wonderful video of Dr. Lenski discussing that program. The use of "evolution in the lab" with bacteria to develop new functions and activities. Possibility of "evolution proof" antibiotics. Work discussed during this podcast from Dr. Hoskisson's laboratory group exploring experimental evolution in Streptomyces. Work discussed during this podcast from Dr. Hoskisson's laboratory group investigating the evolution of natural product synthesis.  Work discussed during this podcast from Dr. Hoskisson's laboratory group investigating the known and unknown genes involved with secondary metabolite production.  Dr. Hoskisson's laboratory group website. Dr. Hoskisson's faculty website. Intro music is by Reber Clark Send your questions and comments to mattersmicrobial@gmail.com

In this insightful episode of Fertility in Focus, Dr. Christina Burns sits down with Dr. Jennifer Kulp-Makarov, MD, FACOG, Board-Certified OB/GYN & REI Specialist, founder of Fleura Fertility. With over 16 years of experience and training at Johns Hopkins and Yale, Dr. Kulp-Makarov shares her patient-centered approach to IVF, individualized protocols, and cutting-edge fertility treatments. Discover how she is transforming the patient experience, optimizing egg quality, and supporting couples, women, and LGBTQIA+ families through a more personalized, stress-free, and effective IVF journey.In This Episode, You'll Learn:How a boutique, patient-focused approach improves IVF outcomes.The benefits of mini IVF and the Goldilocks method for women over 40 or with low AMH.Why individualized FSH monitoring matters for egg quality and success.The importance of considering sperm quality and male fertility in IVF.Advances in PRP and emerging treatments to enhance egg quality.How to set realistic expectations for IVF cycles, stress management, and long-term family planning.How to assess whether a center has a good labThe scoop on rapamycinIns and outs of IVF for egg quality challengesShould you consider Ovarian PRPTimestamps:[00:01] Introduction: Meet Dr. Jennifer Kulp-Makarov and her patient-first philosophy.[01:48] Moving from large IVF centers to a boutique practice: Why patient experience matters.[03:17] The impact of stress, billing, and communication on IVF success.[05:42] Mini IVF and the Goldilocks approach: Personalized, lower-dose protocols.[14:50] Monitoring FSH levels: How adjusting doses improves egg quality.[19:10] Optimizing outcomes for challenging cases: Sperm quality, egg quality, and individualized care.[29:43] Experimental and promising treatments: Rapamycin, ovarian PRP, and future innovations.[32:43] PRP procedures and how they enhance ovarian function.[35:00] Supporting patients emotionally: The importance of a tailored, long-term IVF plan.Connect with Dr. Jennifer Kulp-Makarov & Fleura Fertility:Website: Fleura Fertility Instagram: @FleuraFertility Location: New York City, NYAbout Dr. Christina Burns:Dr. Christina Burns is the founder and Doctor of Chinese Medicine at the Naturna Institute. Committed, compassionate, and highly skilled in multiple disciplines, Dr. Burns has been in practice since 2004. She empowers both women and men to achieve their optimal life and health goals through natural medicine practices, integrative nutrition, lifestyle management, and personalized mind-body programs. Dr. Burns holds advanced certifications in acupuncture, herbs, nutrition, life coaching, and yoga therapy. She is also the best-selling author of "The Ultimate Fertility Guidebook."Connect with Dr. Christina Burns:Website: https://www.christinaburns.com/Instagram: https://www.instagram.com/drchristinaburns/Order the Ultimate Fertility Guidebook: https://a.co/d/hq0nFOoJoin the Eating for Optimal Fertility Course: https://naturna.mn.co/Order Junk Juice: https://junkjuicemagic.com/Follow along with the Naturna Institute:Book an Appointment: https://naturna.janeapp.com/#/listInstagram: https://www.instagram.com/naturna_life/

Cytomegalovirus (CMV) infection is one of the most significant infectious complications after hematopoietic cell transplant (HCT). In this podcast, featuring curated audio from a live satellite symposium, experts Roy F. Chemaly, MD, MPH, FIDSA, FACP, FESCMID and Marcus Pereira, MD, MPH, FAST, discuss the burden of CMV in HCT recipients and explore strategies effectively identify and monitor high-risk patients. Topics include: Epidemiology of CMV among HCT recipients Direct and indirect effects of CMV after HCT Dynamics of risk factors for CMV infection  Strategies for prevention of CMV infection To view the full educational program and download the accompanying slides, visit our website:https://bit.ly/4lfrDTT Presenters: Roy F. Chemaly, MD, MPH, FIDSA, FACP, FESCMID Professor and Chair G.P. Bodey, Sr. Distinguished Professorship in Infectious Diseases President, The International Immunocompromised Host Society (ICHS) Director, Clinical Virology Research Department of ID/IC/EH UT MD Anderson Cancer Center Houston, Texas Marcus Pereira, MD, MPH, FAST Associate Professor of Medicine Director of Clinical Services, Division of Infectious Diseases Medical Director, Transplant Infectious Disease Program Columbia University Irving Medical Center New York, New York Get access to all of our new podcasts by subscribing to the Decera Clinical Education Infectious Disease Podcast on Apple Podcasts, YouTube Music, or Spotify. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Cytomegalovirus (CMV) infection is one of the most significant infectious complications after hematopoietic cell transplant (HCT), but there have been major advances in CMV management to date. In this podcast, featuring curated audio from a live satellite symposium, experts Roy F. Chemaly, MD, MPH, FIDSA, FACP, FESCMID, and Marcus Pereira, MD, MPH, FAST, discuss considerations for CMV treatment in HCT recipients and examine treatment options for refractory/resistant CMV. Topics include: Considerations for CMV management in HCT recipients New definitions of refractory and resistant CMV  Risk factors for refractory and resistant CMV infections Identifying drug-resistant CMV  Treatment options for refractory/resistant CMV To view the full educational program and download the accompanying slides, visit our website:https://bit.ly/4lfrDTT Presenters: Roy F. Chemaly, MD, MPH, FIDSA, FACP, FESCMID Professor and Chair G.P. Bodey, Sr. Distinguished Professorship in Infectious Diseases President, The International Immunocompromised Host Society (ICHS) Director, Clinical Virology Research Department of ID/IC/EH UT MD Anderson Cancer Center Houston, Texas Marcus Pereira, MD, MPH, FAST Associate Professor of Medicine Director of Clinical Services, Division of Infectious Diseases Medical Director, Transplant Infectious Disease Program Columbia University Irving Medical Center New York, New York Get access to all of our new podcasts by subscribing to the Decera Clinical Education Infectious Disease Podcast on Apple Podcasts, YouTube Music, or Spotify. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

 ChatGPT has been in the news a lot lately and, as a result, quite a few STEM-Talk listeners have tossed us questions about the reliability and limitations of generative-artificial intelligence chatbots as well as large-language models more broadly.  Ken and Dawn tackle this question and a number of others in today's Ask Me Anything episode. We have listeners wondering why astronauts train in underwater conditions for spacewalks; icebreakers in antarctica; the value of supplementing with urolithin-A; and the effectiveness of L-citrulline in helping aging blood vessels. Ken also weights in on questions related to lithium deficiency and the onset of Alzheimer's disease; a study that found mTOR activation may not be necessary for ketamine's beneficial effects in the context of depression; and a paper that demonstrated short-term mTOR inhibition by rapamycin improved cardiac and endothelial function in older men. Show notes: [00:02:49] Ken opens our AMA with a listener question for Dawn, which asks why, despite the differences between diving and zero-gravity environments, why do astronauts train in underwater conditions for spacewalks. The listener goes on to mention an article they read about NASA's neutral buoyancy lab in Houston, which contains a partial replica of the International Space Station. [00:07:42] A listener asks Ken if he is still optimistic about the value of supplementing with urolithin-A, and if so, is there a brand he recommends. Ken mentions episodes 118, with Julie Anderson, and 173, with Anurag Singh. Ken also discusses a paper titled “Effect of the mitophagy inducer urolithin A on age related immune decline, a randomized placebo-controlled trial” co-authored by Anurag. Ken also mentions clinical research supporting the urolithin-A supplement Mitopure. [00:10:53] A listener asks Ken about a paper titled “Short-term mTOR inhibition by rapamycin improves cardiac and endothelial function in older men: a proof-of-concept pilot study.” [00:14:29] Ken discusses a 2020 paper from a research group at Yale, which suggested that mTOR activation may not be necessary for ketamine's beneficial effects in the context of depression. The paper also reported that m-TOR suppression via rapamycin might prolong ketamine's antidepressant effects. [00:18:47] A research scientist formerly working in Antarctica asks Ken about Russia's dominance in the realm of ice breakers. [00:23:55] A listener mentions that for some people, when they used ChatGPT to ask about the assassination of political commentator Charlie Kirk, ChatGPT sometimes responded by denying the assassination occurred. The listener asks Ken about the credibility and reliability of generative AI and large-language models. [00:28:49] Several listeners have submitted questions for Ken regarding a paper published in Nature in August of last year titled “Lithium deficiency in the onset of Alzheimer's disease.” Ken gives his thoughts on this paper. [00:31:56] For our final question this AMA, a listener asks Ken about the arginine paradox, which regards L-arginine, which is used by the body to make nitric oxide, which is necessary to relax and maintain flexibility of blood vessels. However, several papers have reported that supplementation of arginine does not reliably improve aging blood vessels. In contrast, recent research suggests that L-citrulline might be more effective. The listeners sent questions asking about the possible effects of citrulline in vascular health and aging. In his answer, Ken cites the following papers: — Administration of L-arginine plus L-citrulline or L-citrulline alone successfully retarded endothelial senescence. — Effects of L-Citrulline Supplementation on Endothelial Function, Arterial Stiffness, and Blood Glucose Level in the Fasted and Acute Hyperglycemic States in Middle-Aged and Older Adults with Type 2 Diabetes. — Citrulline Supplementation Improves Microvascular Function and Muscle Strength in Middle-Aged and Older Adults with Type 2 Diabetes. — Effects of L-citrulline supplementation and watermelon intake on arterial stiffness and endothelial function in middle-aged and older adults: a systematic review and meta-analysis of randomized controlled trials. — Citrulline regulates macrophage metabolism and inflammation to counter aging in mice. If you have questions for Ken and Dawn after listening to today's episode or any episode of STEM-Talk, please email our producer, Randy Hammer, at rhammer@ihmc.org.  Links: Learn more about IHMC STEM-Talk homepage Ken Ford bio Ken Ford Wikipedia page Dawn Kernagis bio    

In this episode of the Egg Whisperer Show, I'm joined by Dr. Steven Palter, founder and medical director of Gold Coast IVF, to explore what happens when fertility care goes beyond quick fixes and becomes true detective work.  Dr. Palter is internationally recognized for his innovative Palter Fertility Method - a systematic, personalized approach that treats infertility as a multilevel disease rather than a one-size-fits-all diagnosis. We discuss how metabolic health, emerging technologies, and surgical precision are transforming outcomes for patients who've been told they're out of options. Read the full show notes on my website. In this episode, we cover: The Palter Fertility Method: diagnostic deep dives, success maps, and the "success spiral" approach to personalized fertility care How insulin resistance drives PCOS and why treating it like "diabetes of the ovary" can reverse infertility The PCOS to Pregnancy Protocol: using continuous glucose monitors, metabolic coaching, and low-carb interventions to restore ovulation PGT-P (preimplantation genetic testing for polygenic conditions): what it is, how it works, and the ethics of screening embryos for complex diseases like autism, Alzheimer's, and diabetes Rapamycin therapy for egg quality: the science behind this longevity drug and why it's showing remarkable results in women over 40 Advanced imaging and surgical techniques that uncover hidden causes of infertility like endometriosis, fibroids, and uterine abnormalities The importance of resistance training, zone-two exercise, and metabolic health for fertility and longevity Resources: Gold Coast IVF: https://www.goldcoastivf.com Dr. Steven Palter on Instagram/TikTok/Facebook: @stevenpaltermd Dr. Aimee's website: https://www.draimee.org/ Do you have questions about IVF?Click here to join Dr. Aimee for The IVF Class. The next live class call is on Monday, March 9, 2026 at 4pm PST, where Dr. Aimee will explain IVF and there will be time to ask her your questions live on Zoom.   Dr. Aimee Eyvazzadeh is one of America's most well known fertility doctors. Her success rate at baby-making is what gives future parents hope when all hope is lost. She pioneered the TUSHY Method and BALLS Method to decrease your time to pregnancy. Learn more about the TUSHY Method and find a wealth of fertility resources at www.draimee.org. Other ways to connect with Dr. Aimee and The Egg Whisperer Show: Subscribe to my YouTube channel for more fertility tips!Subscribe to the newsletter to get updates   Keywords: PCOS treatment, insulin resistance and fertility, Palter Fertility Method, PGT-P polygenic testing, rapamycin for egg quality, embryo genetic screening, metabolic fertility, continuous glucose monitor for PCOS, IVF success rates, unexplained infertility, endometriosis diagnosis, advanced reproductive technology, egg quality improvement, fertility over 40, low carb diet for PCOS, personalized fertility care, Dr. Steven Palter, Gold Coast IVF, reproductive endocrinology, fertility detective work, root cause infertility

As pharmaceutical companies begin rolling out anti-aging drugs for dogs, many pet parents are being told these medications can extend lifespan and prevent cognitive decline. But what are these drugs actually doing inside the body, and at what cost?In this episode, Angela sits down with Carter Easler, Director of Research and Education for CBD Dog Health and MycoDog, to break down the science behind emerging longevity drugs like rapamycin and Loyal. Carter also shares insights from coordinating the Senior Dog Study on cognitive decline, as they explore how pharmaceutical interventions compare to natural strategies that work with the body's own repair systems, including fasting, adaptogens, medicinal mushrooms, and support for the endocannabinoid system.If you have a senior dog, or want to learn about supporting your aging dog before their golden years, this is an episode you won't want to miss.Episode Recap:Angela and Carter talk about the rise of anti-aging drugs for dogs on the market, and why aging is at its core, a loss of homeostasis. (00:00)Rapamycin for dogs, what it does and why it was originally developed. (04:41)Do anti-aging drugs support longevity, or interfere with the body's natural repair processes like autophagy and cellular balance? (07:48)How fasting and restricted feeding windows naturally activate autophagy, support cellular cleanup, and may help extend lifespan in dogs. (11:10)Telomeres, “zombie cells,” and mTOR: how adaptogens, medicinal mushrooms, and hemp modulate aging pathways to support cellular balance instead of blocking the body's natural repair systems. (16:41)Why pharmaceutical “one-target” drugs can create a narrow therapeutic window and unintended side effects, while adaptogens and medicinal mushrooms support all 12 hallmarks of aging. (20:59)The 12 hallmarks of aging explained, from telomere shortening and mitochondrial dysfunction to microbiome imbalance, and how these anti aging drugs are targeting just one of these. (26:06)Why supporting the endocannabinoid system becomes increasingly important as pets grow older. (31:09)Loyal, the upcoming “anti-aging” injection for dogs, undisclosed mechanisms of action, and the importance of informed consent before new veterinary drugs reach the market. (35:20)Why proactive pet wellness should prioritize food, lifestyle, and adaptogenic plant support first, and where pharmaceuticals truly belong in veterinary care. (41:20)They dive into the science behind specific adaptogens and plant compounds, from mitochondrial support and telomere health to metabolic balance and autophagy, and why full-spectrum, whole-plant synergy matters more than isolated compounds. (44:28)Episode Resources:Download Angela's Resources including her Senior Dog Protocol and more at AngelaArdolino.com/podcast-downloads Prospective Evaluation of a Mushroom Derived Nutraceutical in Dogs with Cognitive DeclineWhat We Learned from the Senior Dog StudyMushrooms and Adaptogens for Canine Cognitive DysfunctionHave a question about your pet that you want answered on the podcast? Email us at Angela@AngelaArdolino.com Sign up for episode reminders and updates from Your Natural Dog with Angela ArdolinoVisit Angela Ardolino's website for more holistic pet health education: www.AngelaArdolino.comFollow Your Natural Dog on Facebook and Instagram and if you want to see what Angela is up to, follow her on Facebook or join our CBD & Holistic Pet Advice Facebook Group.

Subscribe to our channel:    / @optispan  Get Our Newsletter (It's Free): https://www.optispan.life/Join Matt and Dr. Nicole (Nicki) Byrne, Clinic Director at Optispan, for a deep dive into preventative Healthspan Medicine. In this episode, they discuss why traditional reactive healthcare is failing us, what true preventative care looks like, and the comprehensive, data-driven approach used at Optispan to catch risks early and optimize long-term health. From advanced diagnostics to lifestyle pillars and evidence-based medications, learn how to shift from treating disease to building resilience.

Pre-Order The Forever Strong PLAYBOOK and receive exclusive bonuses: https://drgabriellelyon.com/playbook/Want ad-free episodes, exclusives and access to community Q&As? Subscribe to Forever Strong Insider: https://foreverstrong.supercast.comAre your immune cells aging faster than you are? In this episode, Dr. Gabrielle Lyon sits down with Dr. Anurag Singh, a leading physician-researcher and Chief Medical Officer at Timeline, to discuss a groundbreaking discovery: the gut-muscle-immune axis. While we often focus on muscle mass for longevity, new research published in Nature Aging reveals that our immune system undergoes a similar decline, with youthful sentinel cells (naive CD8 T-cells) dropping by 75% as we reach age 50. Dr. Singh explains how mitophagy —the targeted recycling of damaged mitochondria—is the key to "rewiring" an aging immune system to fight infection 20% more effectively. In this episode: Alzheimer's of the Muscle: Why sporadic inclusion body myositis (sIBM) is often misdiagnosed as simple aging. The Power of Urolithin A: How this postbiotic compound induces mitophagy to increase mitochondrial abundance by 20% in just 28 days. Immune Imprinting: Why children get 6-8 colds a year while adults only average 2-4. Repurposing Longevity Drugs: Dr. Singh's take on Metformin, Rapamycin, and GLP-1s for life extension. The 1:1 Exercise Rule:Why 150 minutes of moderate activity is the threshold for mitochondrial biogenesis. Thank you to our sponsors: BodyHealth - Use the code LYON 20 to get 20% off your first order https://www.bodyhealthaffiliates.com/73L4QL3/7XDN2/ Timeline - Get 35% off a Mitopure subscription at https://www.timeline.com/drlyon Manukora - Go to https://www.MANUKORA.com/DRLYON to save 31% plus $25 worth of free gifts. Chapters: 0:00 - Can You Tell If Your Immune System Is Healthy? 1:37 - Alzheimer's of the Muscle: Muscle-Immune Dysfunction 5:59 - The Thymus Design Flaw: Why Our Immune "Ammo" Disappears 8:44 - Naive CD8 T-Cells: The Elite Forces of Immunity 12:24 - The Axis of Aging: Mitochondria and Immune Cells in Muscle 16:15 - Mitophagy vs. Autophagy: Targeted Cellular Recycling 19:11 - Study Review: Rewiring the Immune System with Urolithin A 24:13 - Mitochondrial Remodeling: Switching from Glucose to Fatty Acids 27:45 - The Trifecta: Gut-Muscle-Immune Axis Connection 31:13 - Parkinson's and the PINK1/Parkin Mitophagy Pathway 35:04 - Clinical Results: Improving Leg Strength in 4 Months 38:51 - Joint Health: Can We Remodel Cartilage with Mitophagy? 43:34 - Targeted Mitophagy Inducers: Exercise vs. Postbiotics 46:44 - Precision Nutrition: The Ideal Muscle Longevity Supplement 53:33 - Why Alzheimer's is Now Considered an Inflammatory Disease 1:00:13 - The Placebo Effect: You Cannot Deceive the Immune System 1:03:13 - Lymphocyte Counts: The Clinical Marker for Immune Aging 1:08:14 - Rapamycin and Metformin: The Future of Longevity Drugs 1:11:42 - Optimal Dosing: Why 1,000mg of Urolithin A is the Standard 1:15:13 - Sports Medicine: Reducing Muscle Damage Markers (Creatine Kinase) 1:20:03 - The Final Frontier: Brain Aging and Selenium Repair Connect with Dr. Anurag Singh Instagram: @timeline_longevity Website: https://www.timeline.comFind Dr. Gabrielle Lyon at: Instagram:@drgabriellelyon TikTok: @drgabriellelyon

Most conversations about longevity focus on tactics. This episode breaks down the biology underneath them. You'll hear a systems level analysis of how insulin signaling, mTOR, mitochondrial function, inflammation, and nutrient sensing interact to determine biological age, disease risk, and long term human performance. This is not surface level biohacking. It is a deep dive into the mechanisms that actually control aging, metabolism, muscle preservation, and brain optimization, and why most anti aging strategies fail when they ignore these foundations. This all-time classic episode from 2024, has host Dave Asprey joined by Mark Hyman, a practicing physician and one of the most respected leaders in functional medicine. Dr. Hyman is the founder and senior advisor of The UltraWellnessCenter, the founder and former head of strategy and innovation at the Cleveland Clinic Center for Functional Medicine, and a long time advocate for treating root causes instead of managing disease. With over 30 years of clinical experience, his work focuses on restoring mitochondrial health, optimizing metabolism, reversing chronic disease, and slowing biological aging using science backed interventions. Together, Dave and Mark dismantle common myths around protein, carnivore diets, ketosis, fasting, supplements, and longevity drugs. They explain why sugar accelerates aging faster than protein, how mTOR must cycle instead of staying suppressed, and why muscle, mitochondria, and metabolic flexibility matter more than calorie restriction. The conversation also covers nootropics, sleep optimization, neuroplasticity, AI driven diagnostics, and how functional medicine reframes aging as a reversible biological process rather than an inevitable decline. You'll learn: • How insulin and nutrient sensing control aging speed • Why mitochondria sit at the center of longevity and disease • The truth about mTOR, fasting, and protein intake • How ketosis and metabolic flexibility protect long term health • Where supplements and nootropics actually fit in brain optimization • Why functional medicine outperforms symptom based care • How AI and advanced testing are reshaping modern medicine Thank you to our sponsors! - MASA Chips | Go to https://www.masachips.com/DAVEASPREY and use code DAVEASPREY for 25% off your first order. -ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order. -OneSkin | Try OneSkin for 15% off with code DAVE at https://www.oneskin.co/DAVE. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: longevity biohacking, functional medicine longevity, biological age reversal, mitochondria and aging, mTOR pathway aging, insulin resistance and aging, metabolic flexibility, fasting and longevity, ketosis and metabolism, protein intake and mTOR, muscle and longevity, inflammaging, chronic inflammation aging, mitochondrial dysfunction, nutrient sensing pathways, rapamycin longevity, metformin longevity debate, carnivore diet longevity, sugar and aging, brain optimization longevity, neuroplasticity and aging, sleep optimization biohacking, supplements for longevity, anti aging metabolism, human performance optimization, Dave Asprey longevity, Mark Hyman longevity Resources: • Mark's Website: https://drhyman.com/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 - Trailer 0:45 - Introduction 4:49 - Aging as a Treatable Disease 7:50 - The Hallmarks of Aging 14:23 - Nutrient Sensing and Longevity Switches 17:37 - Time Restricted Eating and Autophagy 20:44 - The Four Longevity Pathways 21:49 - Metformin Debate 25:30 - Ozempic and Weight Loss 28:42 - Rapamycin and mTOR 36:23 - Meat, Protein, and Aging 39:46 - Protein Quality and Muscle Synthesis 45:50 - Protein Timing for Muscle Building 48:08 - Metabolic Flexibility 51:32 - Inflammaging 55:26 - Zombie Cells and Senescence See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This is an AMA episode where Dr Matt answers the pressing questions audience had. In this episode, Matt shares candid updates on his TRT journey and physique, debates rapamycin protocols vs. extreme fasting, and separates the scary headlines from the science on microplastics and "magic" mushrooms. Plus: why he wakes up at 4:30 AM, the truth about HBOT, and a surprising update on his books.Timestamps0:00 Intro1:00 Is Matt Still Taking Rapamycin?6:09 Best Time of Day to Take Rapamycin8:29 48-Hour Fasting vs. Rapamycin for Longevity11:44 Why Matt Wakes Up at 4:30 AM14:43 Supplement Updates: Creatine, Astaxanthin & Glycine19:27 Hyperbaric Oxygen Therapy for Brain Health26:04 Epigenetic Clocks vs. Functional Biomarkers30:54 Microplastics: How Worried Should You Be?37:55 Matt's TRT Results After 6 Months43:00 TRT Side Effects: Hair Loss, Blood Work & HDL ChangesThis video was produced by One Billion Media, an agency that specializes in YouTube virality for health brands and experts. Learn more about their work here:https://onebillionmedia.com/DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://x.com/Optispan_IncTwitter:   / mkaeberlein  Linkedin:   / optispan  Instagram:   / optispan_  TikTok:   / optispan  https://www.optispan.life/

Exploring the Microbiome and Longevity with Dr. Ross Pelton, Director of Science & Education for Essential Formulas Inc., which specializes in premium probiotic products. He's known as the Natural Pharmacist. He details the pivotal role of the gut in chronic disease, referencing the ancient insights of Hippocrates, and explores the concept of postbiotics. The conversation touches on the influence of gut health on various organ systems, the importance of diversity in the gut microbiome, and how lifestyle choices like diet, exercise, and sleep contribute to healthy aging. They also tackle cutting-edge topics such as the implications of GLP-1 medications, anabolic resistance, and the potential benefits of rapamycin for longevity.

Dr. Hoffman continues his conversation with Dr. Ross Pelton, Director of Science & Education for Essential Formulas Inc., which specializes in premium probiotic products. He's known as the Natural Pharmacist. 

Join me for a fascinating deep dive into the science of immune aging with Dr. Natalia Mitin, founder and CEO of Sapere Bio. We explore why the aging of the immune system is the primary driver of aging for the entire body and unpack the concept of cellular senescence—often called "zombie cells"—where stressed cells persist and create chronic inflammation. Dr. Mitin explains why consumer tests that assign a specific "biological age" in years are often scientifically lacking compared to measuring where you stand within a population's trajectory. We also discuss cutting-edge longevity targets, including T-cell exhaustion (and how drugs like Rapamycin and SGLT2 inhibitors address it), the critical role of gut health (where 70% of the immune system resides), and how mitochondrial function in stem cells can correlate with an extra 15 years of healthspan.

One on One Video Call W/George https://tidycal.com/georgepmonty/60-minute-meetingSupport the show:https://www.paypal.me/Truelifepodcast?locale.x=en_USThe Lila Code: https://orcid.org/0009-0008-4612-3942

Subscribe to our channel:    / @optispan  Get Our Newsletter (It's Free): https://www.optispan.life/Dive into the future of longevity research with Dr. Ben Blue, CEO of Ora Biomedical. We explore how Ora's high-throughput "Wormbot" platform is conducting the world's largest unbiased search for longevity interventions, moving beyond the narrow focus on established pathways like mTOR.In this episode, we discuss:• The ambitious Million Molecule Challenge and why it could revolutionize the field.• Surprising discoveries already made, including molecules that outperform rapamycin.• Ora's strategic pivot to radiation resistance, with applications for astronauts, pilots, and human health.• How their data-driven approach is uncovering interventions for resilience against toxins and other stresses.• The journey from worm models to potential clinical trials and what's next for the company.Learn how Ora is scaling drug discovery to tackle aging and age-related diseases.https://orabiomedical.com/https://x.com/OraBiomedical  / ora-biomedical-inc  This video was produced by One Billion Media, an agency that specializes in YouTube virality for health brands and experts. Learn more about their work here:https://onebillionmedia.com/Timestamps00:00 – Intro01:13 – Welcome & Disclosure02:40 – Ora Biomedical & the Longevity Mission04:04 – How the Wormbot Was Born06:43 – Matt's Perspective on the Wormbot09:22 – Automating Lifespan Experiments at Scale12:29 – The Million Molecule Challenge15:03 – Success Stories from the Challenge16:10 – A Better mTOR Inhibitor Than Rapamycin19:05 – Ora's Molecule Beats Rapamycin20:08 – 60% Lifespan Extension Discovery24:03 – Ivermectin & Surprising Findings24:55 – From Longevity to Anti-Parasite Drugs31:09 – Hot Take: Discovery vs. Mechanism35:22 – The Million Molecule Challenge Database40:45 – Radiation Resistance: A New Focus44:57 – Space Travel & Longevity Medicine49:18 – Testing Resilience to Toxins & Stress56:54 – What Thousands of Tests Reveal About Aging Pathways01:00:41 – False Positives vs. False Negatives in Screening01:04:45 – Skin Health & Anti-Aging Potential01:07:59 – What's Next for Ora BiomedicalDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://x.com/Optispan_IncTwitter:   / mkaeberlein  Linkedin:   / optispan  Instagram:   / optispan_  TikTok:   / optispan  https://www.optispan.life/

Can science really help us live longer - and feel better while we age? In this episode, longevity expert Kayla Barnes-Lentz joins Jonathan and Dr Federica Amati to explore how daily behaviours, emerging science, and personalised data may shape our health span. Many people believe longevity requires extreme routines or expensive treatments, but new evidence suggests simple habits may have a powerful impact. This conversation asks one central question: how can we age well while still enjoying life? Together, Kayla, Jonathan and Federica explore what longevity science currently understands… and what it still doesn't. Kayla shares her personal journey from chronic fatigue and brain fog to measurable improvements after changing her diet, sleep routine and lifestyle. The discussion covers nutrition, sleep, oral health, fasting, environmental toxins, supplements, wearable tracking, personalised lab testing, and why women may need different guidance based on physiology and life stage. For listeners wanting practical steps, this episode includes guidance on five foundational habits such as consistent sleep timing, reducing late-evening eating, flossing and dental check-ins, supporting your gut and oral microbiome, and increasing plant diversity in meals.  As science continues to uncover how and why we age, what small behaviour could you change today that your future self may thank you for? And if you could meaningfully extend your healthy years, how differently might you live now? Unwrap the truth about your food

Just 4 simple lifestyle measures deliver 9 additional years of disease-free healthspan; Study underscores protein's role in staving off cancer, heart disease, and death; CoQ10 scores vs. neurodegeneration; Urolithin A (Mitopure®️) found to support athletic performance, immune function; Why you should ignore some influencers' advice to avoid fish oil. 

My guest is Dr. David Fajgenbaum, MD, professor of translational medicine and human genetics at the University of Pennsylvania. He explains how, unbeknownst to most doctors, many approved medications can successfully treat or even cure diseases other than the ones they are typically used to treat. He shares his story of escaping death from Castleman's disease by discovering a life-saving treatment using repurposed drugs that were approved for other purposes. Our conversation explores how researchers, physicians, and you—the general public—can explore novel treatments and cures to conditions the medical profession has deemed untreatable, including cancers. We also discuss the crucial role of mindset in battling diseases and the lesser-known use of compounds to promote health and longevity. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AGZ by AG1: https://drinkagz.com/huberman Eight Sleep: https://eightsleep.com/huberman Rorra: https://rorra.com/huberman David: https://davidprotein.com/huberman Function: https://functionhealth.com/huberman Timestamps (0:00) David Fajgenbaum (4:06) Self-Agency in Healthcare; New Uses for Old Medicines (6:44) Other Uses of Aspirin & Viagra; Drug Development & Approved Use (8:53) Lidocaine & Breast Cancer; Pharmaceutical Companies & Incentives (11:36) Sponsors: Eight Sleep & Rorra (14:16) Pharmaceutical Companies, Patents & New Uses; Lithium (18:40) Tools: Finding Reliable Health Sources, Asking Questions & Disease Organizations; DADA2 Treatment (21:53) Medical Community & Connections; Integrated Medical Databases (24:36) Drug Repurposing, Thalidomide, Pembrolizumab (28:45) Medical Research Databases, Mapping Disease Connections (33:51) Every Cure Database & Programs, Bachmann-Bupp Syndrome; Colchicine & Heart Disease (37:57) Sponsors: AGZ by AG1 & David (40:41) David's Medical & Career Journey, Glioblastoma, Castleman Disease (49:10) Autoimmune Disease, Driven Personality, Stress & Immune System (52:52) Castleman Disease, Treatment, Chemotherapy (55:54) Physician Continuing Education, Santa Claus Theory of Civilization; Science Collaboration (1:03:32) Medical School, Relapse & “Overtime”, Finding a New Treatment, Rapamycin (1:12:46) Sport, Football & Resilience; Challenge & Personal Growth, Family (1:18:41) Sponsor: Function (1:20:29) Social Support; “Overtime”, Gratitude (1:23:19) Business School, Castleman Disease Treatment; Repurposing Drugs & AI (1:28:29) Drug Repurposing, POEMS Syndrome; Mitigating Risk (1:35:32) Nicotine, Compounds for Preventive Health; GLP-1 Agonists (1:40:51) Bioprospecting, Drug Development; AI, Prioritization & Novel Connections (1:46:18) Healthcare & Children; Hope, Action & Impact Circuit; Challenge & Super-Agers (1:52:50) Get Involved with Every Cure (1:56:20) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

In this podcast, I sit down with Dr. Jon Berner to explore two of the most promising yet misunderstood therapeutic agents: Lithium and Rapamycin.We begin with a groundbreaking discussion on Lithium, moving far beyond its traditional use in psychiatry. We break down the recent landmark study in Nature that positions lithium as a potential powerhouse for combating Alzheimer's disease, delve into the different salts (orotate vs. carbonate), and discuss who might benefit, who should be cautious, and the practical realities of dosing and side effects.In the second half, we shifted to Rapamycin, focusing on an exciting new preprint study on its use for Chronic Fatigue Syndrome (ME/CFS). We explore the compelling "hyperinflammatory" hypothesis for ME/CFS and long COVID, question whether current off-label dosing is too low, and debate the classic mTORC1 vs. mTORC2 model. The conversation also covers radical new ideas like high-dose pulse therapy, its potential use in IVF, and the powerful synergy of combining rapamycin with ketamine for treatment-resistant conditions.Throughout, we tackle the larger themes of personalized medicine, the limitations of the FDA, and how new AI-driven tools are beginning to map the complex, N-dimensional biochemical space of human health.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this “Ask Me Anything” (AMA) episode, Peter revisits the “proven, promising, fuzzy, noise, nonsense” scale and applies it to a variety of popular topics. He begins with a refresher on what each category represents before classifying a range of interventions based on the strength of their supporting evidence. The conversation spans three main areas: drugs for geroprotection (including GLP-1 receptor agonists, SGLT2 inhibitors, methylene blue, and telomere-lengthening supplements), the use of low-dose aspirin for cardiovascular disease prevention, and strategies to improve muscle mass through optimal protein intake and follistatin gene therapy. This episode provides a clear, evidence-based overview for listeners seeking to understand where these popular health and longevity interventions stand on the spectrum of scientific credibility. If you're not a subscriber and are listening on a podcast player, you'll only be able to hear a preview of the AMA. If you're a subscriber, you can now listen to this full episode on your private RSS feed or our website at the AMA #76 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here. We discuss: A scale for evaluating scientific claims: proven, promising, fuzzy, noise, or nonsense [1:30]; Strong convictions, loosely held: the mindset that separates great scientists from the rest [7:30]; GLP-1 receptor agonists: are there benefits beyond improving metabolic health and promoting weight loss? [12:45]; GLP-1 drugs and the brain: exploring the potential cognitive benefits [18:45]; GLP-1 drugs and lifespan: examining the evidence for potential geroprotective effects [23:00]; Rapamycin and geroprotection: why it remains in the “promising” category [25:45]; SGLT2 inhibitors and their potential geroprotective effect [27:30]; Methylene blue: examining the evidence of an anti-aging effect [34:45]; Methylene blue's potential neuroprotective effects: limited and inconsistent evidence in humans, and the challenges of dosing and safety [41:15]; Telomeres: what they are, how they relate to aging, and why telomere-lengthening supplements lack credible scientific evidence [43:45]; Does the idea of targeting telomere length to extend lifespan have scientific merit? [50:15]; Low-dose aspirin for cardiovascular disease prevention: weighing its clot-prevention benefits against bleeding risks across different populations [55:00]; Rethinking the protein RDA: why most people need twice the recommended amount for muscle health [1:00:45]; Debunking the protein–cancer myth: why higher protein intake doesn't promote tumor growth [1:06:15]; The biology of follistatin and myostatin, and why follistatin gene therapy has become an emerging topic of interest for muscle growth [1:13:15]; Follistatin gene therapy for muscle growth: state of the evidence in animals and humans, and the technical challenges and regulatory barriers [1:17:00]; Why injectable follistatin is theoretically possible but impractical for real-world use [1:23:15]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

Subscribe to our channel:    / @optispan  Get Our Newsletter (It's Free): https://www.optispan.life/Join me for an in-depth conversation with Dr. Alex and Dr. Jan from the YEARS Healthspan Clinic in Berlin. They pull back the curtain on what a truly evidence-based, scientific approach to longevity medicine looks like, moving beyond the hype and "snake oil" to focus on rigorous diagnostics, personalized interventions, and the critical collection of high-quality data.In this episode, they delve into the comprehensive 6+ hour diagnostic workup I am about to undergo, discuss the hierarchy of interventions (from lifestyle as the foundation to the careful use of pharmaceuticals), and debate the role of supplements, peptides, and more experimental therapies. This is a masterclass in the practical application of healthspan medicine from leading clinicians in the field.This video was produced by One Billion Media, an agency that specializes in YouTube virality for health brands and experts. Learn more about their work here:https://onebillionmedia.com/Timestamps:00:00 – Trailer01:12 – Introduction02:19 – Inside the 6-Hour Health Assessment05:00 – Full-Body MRI & Advanced Testing11:57 – Biological Age Tests & Organ-Specific Clocks17:10 – "Scientific Healthspan" vs. Longevity Medicine25:50 – Reversing Type 2 Diabetes: A Real-World Case31:42 – Supplements: Separating Facts from Fads43:20 – Rapamycin, GLP-1s & Metformin: What's Proven?54:00 – Muscle Loss, Brain Health & Alzheimer's Prevention01:05:11 – Stem Cells, Exosomes & Peptides: Hype or Hope?01:12:57 – No Shortcuts: The Need for Clinical Trials01:17:47 – Preventive Cardiology & Lipid Management01:26:52 – Hormone Therapy: Men, Women & Misconceptions01:33:12 – The Longevity Field's Biggest Problem01:39:05 – "Dr. ChatGPT" & The Self-Diagnosis Dilemma01:43:14 – Why Healthcare Must Change Now01:45:26 – Closing ThoughtsDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://x.com/Optispan_IncTwitter:   / mkaeberlein  Linkedin:   / optispan  Instagram:   / optispan_  TikTok:   / optispan  https://www.optispan.life/Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

“The Evolution of Cancer and Ageing: A History of Constraint” (Nature Reviews Cancer). Fascinating perspective on how tumour suppression mechanisms that protect us early in life may ironically fuel age-related decline later on. ⚖️   From telomeres

Read the full show notes on Dr. Aimee's website. I'm excited to be joining Dr. Lorne Brown on the Conscious Fertility Podcast to dive into a fascinating topic: Rapamycin. While it's started to be used as an anti-aging drug, I've been exploring its potential for reproductive health, especially in improving fertility and delaying menopause.  In this episode, I share my personal experience taking Rapamycin, including how it's affected my skin, menstrual cycles, and overall health. We'll also get into the science behind it and how it may be beneficial for women going through menopause or undergoing fertility treatments like IVF.  While I'm passionate about this topic, I want to emphasize that this is not medical advice—always consult your doctor before considering any new treatments. I also share how my alcohol-free lifestyle supports my approach to healthy aging and fertility. Key points covered include: How Rapamycin may help delay menopause, reverse its effects, and support fertility treatments. Some of the potential side effects, like cystic acne and mouth sores. Why I started using and prescribing Rapamycin for longevity and helping women improve fertility later in life. My personal experience with Rapamycin, including smoother skin, regular cycles, and no gray hair at 48. The importance of consulting your doctor before trying Rapamycin, as this podcast is informational and not meant as medical advice. Get the full show notes on Dr. Aimee's website. Listen to Dr. Aimee interview Dr. Lorne Brown about about conscious fertility and psychoneuroimmunology. You can find Dr. Brown here Conscious Fertility Podcast Dr. Lorne Brown On Instagram Dr. Aimee's list of supplements Do you have questions about IVF?Click here to join Dr. Aimee for The IVF Class where Dr. Aimee will explain IVF and there will be time to ask her your questions live on Zoom.   Subscribe to my YouTube channel for more fertility tips!Subscribe to the newsletter to get updates  Dr. Aimee Eyvazzadeh is one of America's most well known fertility doctors. Her success rate at baby-making is what gives future parents hope when all hope is lost. She pioneered the TUSHY Method and BALLS Method to decrease your time to pregnancy. Learn more about the TUSHY Method and find a wealth of fertility resources at www.draimee.org.

Upgrade your week in just 10 minutes with D(AI)ve Asprey's essential rundown on what matters most in longevity, biohacking, AI health tech, and medical freedom. Each story includes trusted source links—so you can check the facts. This episode covers: - Rapamycin's Reality Check: A sweeping new review (September 24) finds that the promise of rapamycin for longevity in healthy adults is still weak and inconsistent. Dave shares why lifestyle levers (fasting, protein timing, smart training) come first, and any rapamycin experiment should be clinician-guided and tracked with labs. Source: Aging-US press release – September 24, 2025 and EurekAlert science brief – September 24, 2025 - Senolytics Get Precise: New research (September 23) shows that not all “zombie cells” (senescent cells) are equal in how they respond to anti-aging drugs—so future protocols will be timed and typed, not one-size-fits-all. Source: Aging-US research stream – September 23, 2025 - AI Healthcare: Promise and Pause: The latest market outlook (September 23) says AI in healthcare is surging toward a $100B+ market by 2030, but 70% of doctors still want humans in the loop for diagnosis. Dave shares how to use AI as your copilot—not your captain. Source: Crescendo.ai – September 23, 2025 - Medical Policy Meets Machine Logic: A new federal pilot now lets AI approve or deny Medicare coverage, possibly cutting off therapies before a human review happens. Dave explains how to demand explainability, fair appeals, and human override to protect access. Source: KFF Health News policy rundown – September 25, 2025 - Longevity Headlines You Can Use: Forest bathing wins renewed praise for helping with blood pressure and stress. Northwestern's SuperAger project links strong social ties to resilient brain health. Human trials now test an antibody therapy to regrow lost teeth. Source: XandroLab Longevity Roundup – Week of Sept 22–25, 2025 Action steps for the week: Try fasting windows and smart protein clustering for mTOR modulation. Let AI help summarize your health data—but get decisions confirmed by your clinician. If you or your family touch Medicare, keep thorough documentation and demand human review. Soak in green spaces, reconnect socially, and watch for cutting-edge therapies. All source links provided for easy reference to the original reporting and research above. This is essential listening for fans of biohacking, hacking human performance, functional medicine, and longevity who want actionable tools from Host Dave Asprey and a guest who embodies what it means to age with energy, clarity, and vitality. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday (audio-only), and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Rapamycin, mTOR modulation, longevity, biohacking, senolytics, zombie cells, AI healthcare, Medicare coverage, human trials, forest bathing, SuperAger, brain health, fasting, protein cycling, medical freedom, anti-aging, personalized medicine, health tech, Dave Asprey, Human Upgrade podcast Thank you to our sponsors! LYMA | Go to https://lyma.sjv.io/gOQ545 and use code DAVE10 for 10% off the LYMA Laser. KILLSwitch | If you're ready for the best sleep of your life, order now at https://www.switchsupplements.com/ and use code DAVE for 20% off. Resources: • Danger Coffee: https://dangercoffee.com/discount/dave15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Intro 0:18 — Rapamycin Hype Check 1:07 — Senolytics Leveled Up 2:41 — AI in Healthcare 3:11 — AI Between You and Your Doctor 5:50 — Three Longevity Angles 7:59 — Outro See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

SummaryIn this episode of the Neuroveda podcast, host Gillian Ehrlich engages with Dr. John Berner, a Harvard-trained psychologist and neuroscientist, to explore the intricate relationship between mind and body in the context of mental health. They discuss the limitations of traditional medical silos, the importance of cellular communication, and the role of hormones in health. Dr. Berner introduces the concept of intersectionality in psychiatric treatment, emphasizing the need for personalized approaches. The conversation also delves into innovative treatments like rapamycin and the significance of understanding cellular interactions through advanced technologies.TakeawaysMind-body medicine should not separate mental and physical health.The shift from Newtonian to quantum thinking is crucial in medicine.Cellular communication is a localized and complex process.Hormones play a central role in coordinating bodily functions.Understanding evolutionary constraints can inform health practices.Intersectionality is key in treating mental health conditions.Rapamycin shows promise in extending lifespan and improving health.Eavesdropping on cellular conversations can enhance treatment strategies.Innovative technologies can measure cellular responses effectively.Biology is complex and cannot be simplified into binary categories.BioDr. Jon Berner, a Harvard-trained psychologist, UCLA-trained neuroscientist and physician, and University of Washington–trained psychiatrist. With over 25 years in clinical practice, his work bridges rigorous neuroscience, psychiatry, and compassionate patient care. Dr. Berner's publications span from the cognitive effects of cocaine and memory in schizophrenia to pioneering treatments with ketamine, rapamycin, and novel metabolomic approaches for mood and pain disorders. He brings a unique lens—uniting neural networks, biochemistry, and clinical psychiatry—to reimagine how we treat complex mental health conditions with both precision and humanity.

Can a decades-old drug unlock new possibilities for longevity? Rapamycin, originally discovered in the 1970s on Easter Island, was once used solely as an anti-rejection medication for organ transplants. Today, at much lower and less frequent doses, it is being studied and repurposed for its potential to extend health span, reduce inflammation, and support overall vitality. In this episode, Bryana Gregory, pharmacist and physician liaison, breaks down the history of rapamycin, the design and findings of the 2024 Pearl Study, and why proper compounding matters for bioavailability and effectiveness. She also explains how this drug works on the mTOR pathway, helping improve cellular function, brain clarity, skin health, and even bone density and lean muscle mass in some patients. If you're curious about repurposed drugs, longevity, or ways to reduce inflammation naturally, this discussion sheds light on how rapamycin may become an important tool for the future of wellness. Watch now and subscribe to our podcasts at www.HotzePodcast.com. To receive a FREE copy of Dr. Hotze's best-selling book, “Hormones, Health, and Happiness,” call 281-698-8698 and mention this podcast. Includes free shipping!

The Breaking Point: When Stress Nearly Killed a Doctor Dr. King's wake-up call came when blood work revealed she was pre-diabetic with microvascular heart disease and stage 3 kidney dysfunction - all from the chronic stress of insurance-based practice.00:00 The Final Straw: 18 Years to Rock Bottom 01:00 From GYN Surgeon to Longevity Medicine Pioneer02:14 The Importance of Having a Backup Plan: A4M Fellowship 02:42 Personal Catalyst: Mother's Cancer Journey and Medical System Failures 04:32 Why Generic Concierge Franchises Fall Short 06:45 Breaking Free from Insurance Constraints 08:43 Quality of Care: From 15-Minute Visits to 2-Hour Consultations 10:38 The Insurance Punishment System in Action 12:29 Market Analysis: 73% of Patients Could Afford Concierge Care 14:00 Detective Medicine: The Acid Blocker Case Study 15:30 Advanced Testing Reveals Universal Toxicity 16:13 The Plasticizer Mystery: Salon Paw Patches 19:25 Evolution of Regenerative Medicine: From Bone Marrow to PDGF 22:28 Legal vs. Underground Stem Cell Treatments 24:26 The Future: Joint Regeneration vs. Replacement 28:14 Root Cause Medicine vs. Pharmaceutical Band-Aids 31:16 Personal Health Transformation: 75 Pounds and Optimal Markers 36:04 The Longevity Vision: Banking on Escape Velocity 42:40 Advanced Longevity Protocols: Rapamycin and Personalized Medicine 45:12 The Aristotle Test: AI-Powered Metabolic Optimization 49:00 Life's Too Short: Why Waiting Is the Biggest Risk 51:48 The Glyphosate Reality: Even Organic Farms Show Toxicity 52:50 The Fit 40-Year-Old Pre-Diabetic Epidemic

Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Longevity scientist Dr. Matt Kaeberlein systematically breaks down ten of the most persistent myths in the health and aging space. From the truth about biological age tests and resveratrol to the real role of genetics and supplements, this episode separates scientific fact from expensive fiction.0:00 - Intro: A New Series on Longevity Myths0:49 - Myth 1: Can You Actually "Measure" Biological Age?5:05 - Myth 2: Are Supplements a "Core" Longevity Strategy?6:29 - Myth 3 & 7: "I'm Too Old" & The Role of Your Genes8:16 - Myth 4 & 6: The FDA & The Truth About Research Funding10:49 - Myth 5: The Resveratrol Lie20:24 - Myth 8: The Caloric Restriction Misconception23:52 - Myth 9 & 10: The Reality of Rapamycin & PeptidesProduction: Nicholas Arapis, https://videocastproductions.comDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://x.com/Optispan_IncTwitter: https://twitter.com/mkaeberleinLinkedin: https://www.linkedin.com/company/optispanInstagram: https://www.instagram.com/optispan_/TikTok: https://www.tiktok.com/@optispanhttps://www.optispan.life/Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

As he finished his medical school exam, David Fajgenbaum felt off.  He walked down to the ER and checked himself in.  Soon he was in the ICU with multiple organ failure.  The only drug for his condition didn't work. He had months to live, if that.  If he was going to survive, he was going to have to find his own cure. Miraculously, he pulled it off in the nick of time. From that ordeal, he realized that our system of discovering and approving drugs is far from perfect, and that he might be able to use AI to find dozens, hundreds, even thousands of cures, hidden in plain sight, for as-yet untreatable diseases. EPISODE CREDITS:Reported by - Latif NasserProduced by - Maria Paz Gutiérrezwith mixing help from - Jeremy S. BloomFact-checking by - Natalie A. MiddletonVISIT:Everycure.org (https://www.everycure.org)EPISODE CITATIONS:Books -Blair Bigham -  Death Interrupted: How Modern Medicine is Complicating the Way We DieDavid Fajgenbaum - Chasing My Cure, (https://davidfajgenbaum.com/)Radiolab | Lateral Cuts:Check out Death Interrupted (https://radiolab.org/podcast/death-interrupted), a conversation with Blair Bigham about a worldview shifting change of heart.The Dirty Drug and the Ice Cream Tub (https://radiolab.org/podcast/dirty-drug-and-ice-cream-tub) to hear the crazy story about how Rapamycin was discovered.Signup for our newsletter!! It includes short essays, recommendations, and details about other ways to interact with the show. Sign up (https://radiolab.org/newsletter)!Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today.Follow our show on Instagram, Twitter and Facebook @radiolab, and share your thoughts with us by emailing radiolab@wnyc.org.Leadership support for Radiolab's science programming is provided by the Simons Foundation and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.

Dive into the fascinating world of longevity research as we explore rapamycin, potentially the most powerful anti-aging pharmaceutical currently known. Dr. Rick Cohen, longevity physician with over 25 years of experience, reveals how this natural molecule discovered on Easter Island targets a fundamental cellular pathway called mTOR that acts as our body's metabolic switch between growth and repair.This episode is sponsored by Gatlan who makes rapamycin that we will be discussing available in their program. I am an advisor to Gatlan but I only advise companies that I believe in and would use for myself and my family. The conversation uncovers the remarkable story behind rapamycin's discovery - how it sat forgotten in a researcher's freezer for years before its life-extending properties were recognized. Dr. Rick explains that mTOR has been conserved through billions of years of evolution precisely because it's so critical to survival, sensing nutrient availability and telling cells whether to grow or repair themselves.What makes this discussion particularly valuable is Dr. Rick's practical approach to using rapamycin as a metabolic health tool rather than a miracle drug. He shares insights on proper dosing strategies, emphasizing the importance of cycling between periods of mTOR suppression and activation to mimic natural patterns our bodies evolved with. This cycling approach - perhaps taking rapamycin for a few months, then taking a month off for anabolic growth through strength training - may be key to optimizing its benefits.The breadth of rapamycin's benefits is truly remarkable - from hair regrowth and skin rejuvenation to improvements in hearing, fertility, and protection against diseases ranging from Alzheimer's to atherosclerosis. This suggests rapamycin isn't just treating symptoms but addressing a fundamental mechanism of aging itself.Ready to understand how this single pathway could influence every aspect of how we age? Listen now to discover why balancing growth and repair cycles might be the key to extending your healthspan and potentially your healthspan and potentially your lifespan.https://www.gatlan.com/Lies I Taught In Medical School : Free sample chapter- https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (LUFKIN20 for 20% off) https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (20% off) https://siphoxhealth.com/lufkinMimio Health (LUFKIN for 15% off) https://mimiohealth.sjv.io/c/5810114/2745519/30611 Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmdInstagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/TikTok: https://www.tiktok.com/@robertlufkinThreads: https://www.threads.net/@robertlufkinmdFacebook: ...

Interview with Ehsan Rahimy, MD, author of Mammalian Target Rapamycin Inhibition as a Therapeutic Target for Prevention of Proliferative Vitreoretinopathy. Hosted by Neil Bressler, MD. Related Content: Mammalian Target Rapamycin Inhibition as a Therapeutic Target for Prevention of Proliferative Vitreoretinopathy

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Brian Kennedy is a renowned biologist, leader in aging research, and director of the Center for Healthy Longevity at the National University of Singapore. In this episode, Brian shares insights from ongoing human aging studies, including clinical trials of rapamycin and how dosing strategies, timing, and exercise may influence outcomes. He presents two key models of aging—one as a linear accumulation of biological decline and the other as an exponential rise in mortality risk—and explains why traditional models of aging fall short. He also explains why most current aging biomarkers lack clinical utility and describes how his team is working to develop a more actionable biological clock. Additional topics include the potential of compounds like alpha-ketoglutarate, urolithin A, and NAD boosters, along with how lifestyle interventions—such as VO2 max training, strength building, and the use of GLP-1 and SGLT2 drugs—may contribute to longer, healthier lives. We discuss: Brian's journey from the Buck Institute to Singapore, and the global evolution of aging research [2:45]; Rethinking the biology of aging: why models like the hallmarks of aging fall short [9:45]; How inflammation and mTOR signaling may play a central, causal role in aging [14:15]; The biological role of mTOR in aging, and the potential of rapamycin to slow aging and enhance immune resilience [17:30]; Aging as a linear decline in resilience overlaid with non-linear health fluctuations [22:30]; Speculating on the future of longevity: slowing biological aging through noise reduction and reprogramming [33:30]; Evaluating the role of the epigenome in aging, and the limits of methylation clocks [39:00]; Balancing the quest for immortality with the urgent need to improve late-life healthspan [43:00]; Comparing the big 4 chronic diseases: which are the most inevitable and modifiable? [47:15]; Exploring potential benefits of rapamycin: how Brian is testing this and other interventions in humans [51:45]; Testing alpha-ketoglutarate (AKG) for healthspan benefits in aging [1:01:45]; Exploring urolithin A's potential to enhance mitochondrial health, reduce frailty, and slow aging [1:05:30]; The potential of sublingual NAD for longevity, and the combination of NAD and AKG for metabolic and exercise enhancement [1:09:00]; Other interventions that may promote longevity: spermidine, 17

Gil and Eric discuss Eric's book, Super Agers, and the inspiration behind it: a 98-year-old patient who exemplified healthy aging. They explore the five dimensions of healthspan optimization: lifestyle, omics, the immune system, and the role of data and AI in personalized medicine. Eric highlights how AI can analyze multi-layered data to provide personalized recommendations for preventing age-related diseases.The conversation also explores the importance of exercise, sleep, and social connection for healthy aging, as well as the risks associated with high-dose statins. Eric emphasizes the need for a shift towards preventative care, using data and AI to identify and address individual risks. He stresses the power of lifestyle changes, rather than supplements, in improving long-term health outcomes.  Guest-at-a-Glance 

I'm diving deep with Regan Archibald, an absolute peptide and regenerative medicine genius to unearth mind-blowing therapies that fight aging, melt fat, heal your body, and sometimes even help you skip surgery entirely. If you're tired, feeling older than your age, or frustrated that traditional protocols aren't moving the needle, you need to hear this. We break down why most people barely scratch the surface when it comes to peptides and why these little protein messengers are the secret to amplifying your results—think faster gut healing, squashing mold toxicity, supercharging immune resilience, and getting you vibrant again on a cellular level. From innovative gut-healing protocols to stacking the right peptides for real transformation, Reagan drops gems that will completely shift your expectations about how fast and radically you can upgrade your health. We also talk muscle preserving, fat-burning, body composition-boosting peptide stacks, and why Rapamycin and Metformin could be sabotaging your muscle building goals as you age. Think next level breakthroughs: exosomes, stem cells and the new world of plasma renewal therapy that's basically an oil change for your blood. Whether you're struggling with pain, aiming for a killer physique, or curious about brain optimization and the future of longevity medicine, this episode is packed with protocols, client stories and takeaways that just might blow your current health plan out of the water. Work with Regan Archibald and his Team https://acueastwest.com/ WHAT DO MY LABS MEAN?! Try the ultimate tool to Decode Your Labs: Understand your thyroid, hormones, and blood sugar numbers to transform your health https://dramie.com/labs/ We prescribe to all 50 states!  When you're ready to FINALLY get the help you deserve… Book a free application call: https://dramie.com/book-a-call/ Shop ALL of Dr. Amie's Fixxr® Supplements: https://betterlifedoctor.com/ EARN CE Credits: "Nurses, hold-on  – here comes the exciting part: you can earn nursing CE credits by listening to our podcasts! That's right—RNegade has teamed up with podcast hosts like me who are delivering amazing content that doesn't limit you to “thinking outside-the box,” it challenges you to BLOW-UP the box by learning from innovators, pioneers, and RENEGADES in the field of health and medicine WHILE EARNING YOUR CEs!” https://rnegade.thinkific.com/?ref=4d98d0 RATE, REVIEW AND FOLLOW ON APPLE PODCASTS If you made it this far I'm impressed! That means you really love the show and I love you for that!  So I'm going to ask you for a favor. Would you please leave a quick review or even 5⭐️. I DO read them and can't tell you how much I appreciate it! Thank you in advance!❤️  Just click here it's quick and easy : https://podcasts.apple.com/us/podcast/the-thyroid-fixer/id1529800263,  Ok ONE MORE favor…would you please subscribe and follow the show? This is a win-win! It tells the podcast powers that be that you like The Thyroid Fixer Podcast AND it lets you catch all the new episodes that come out every week. Follow with this link: https://podcasts.apple.com/us/podcast/the-thyroid-fixer/id1529800263 and never miss out on a moment of the journey! CONNECT WITH ME ON SOCIAL MEDIA: Want to get your labs reviewed and your questions answered LIVE by me? Join my exclusive Facebook group, Just Fix Your Thyroid – a supportive and empowering community designed to give you the tools, guidance, and HOPE you need on your thyroid and hormone journey.

In this first-ever AMA episode, Dave tackles your biggest biohacking questions—straight from The Upgrade Collective! From optimizing brain power to pushing the limits of cold therapy, this episode is packed with cutting-edge hacks to supercharge your body and mind. If you'd like to have your questions answered on the next AMA, click the link below for details on The Upgrade Collective membership, and get all sorts of extra biohacking add-ons for your life! In today's episode: What if you could amplify oxytocin—the “love hormone”—to build stronger relationships and lower stress? Or upgrade your cold plunge routine for max benefits in less time? Dave reveals the science behind these powerful biohacks, plus his take on rapamycin for longevity, the right way to supplement for thyroid health (without a prescription), and even how he personally overcame Asperger's traits through neuroplasticity and mitochondrial upgrades. There's even some great advice for all the parents out there! What You'll Learn: • How to naturally boost oxytocin for better relationships and emotional health • The fastest way to upgrade your cold plunge for heat shock benefits • Is rapamycin really a longevity miracle? Dave's personal take • How mitochondria impact brain power, mood, and aging—and how to fix them today! • The shocking reason some people can't process reality correctly (and how to retrain your brain) • The real truth about stem cells, exosomes, and V-cells for regeneration • The hidden dangers of selenium, thyroid supplements, and over-fasting SPONSORS -Puori | Visit https://puori.com/dave and use code DAVE for 20% storewide. -Calroy | Head to https://calroy.com/dave for an exclusive discount. Resources: • Upgrade Collective Membership: https://www.ourupgradecollective.com • Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey's Website: https://daveasprey.com • Dave Asprey's Linktree: https://linktr.ee/daveasprey • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 – Intro • 00:37 – Welcome to the Human Upgrade AMA • 01:13 – Cold Plunges and Alpha Lipoic Acid for Health • 03:11 – Hot and Cold Therapy for Optimal Health • 07:29 – Understanding Thyroid Health and Treatment • 09:09 – The Importance of Selenium • 14:41 – Stem Cells vs. Exosomes • 16:27 – Rapamycin for Longevity • 18:07 – Asperger's Syndrome and Neuroinflammation • 28:53 – Understanding Asperger's and Self-Awareness • 29:24 – The Challenge of Offering Help • 30:06 – The Importance of Reconnection Work • 31:34 – Personal Development Journey • 34:42 – The Role of Emotions in Biohacking • 35:55 – Dealing with Flashbacks and Trauma • 45:46 – The Power of Oxytocin • 49:48 – The Truth About Kale and Oxalates • 54:25 – Teaching Kids to Regulate Their Nervous System See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Dr. Keith Baar is a Professor at the University of California, Davis in the Department of Physiology and Membrane Biology. During his Ph.D. studies, his research revealed that mechanical strain on muscle fibers activates the mammalian target of rapamycin (mTOR) signaling pathway, a crucial regulator of muscular hypertrophy. Subsequently, he studied the molecular dynamics of skeletal muscle adaptation to endurance training under the guidance of Dr. John Holloszy, a legend in the field of exercise physiology, considered the father of modern exercise biochemistry. Building on all of this experience, he conducted research into tendon health and the potential for engineering ligaments, which could have implications for treatment and recovery from injuries.Sponsors:Cresset prestigious family office for CEOs, founders, and entrepreneurs: https://cressetcapital.com/tim (book a call today)AG1 all-in-one nutritional supplement: https://DrinkAG1.com/Tim (1-year supply of Vitamin D (and 5 free AG1 travel packs) with your first subscription purchase.)Shopify global commerce platform, providing tools to start, grow, market, and manage a retail business: https://shopify.com/tim (one-dollar-per-month trial period)*Links to everything discussed: https://tim.blog/2025/02/26/dr-keith-baar/Timestamps:[00:00:00] Start [00:07:12] How I discovered Keith's work through a tweet about tennis elbow and rock climbing.[00:07:54] Emil Abrahamsson's hangboard training protocol.[00:09:20] The fundamental principles of strength training and connective tissue adaptation.[00:10:36] mTOR complex 1 and its role in muscle growth.[00:12:06] Engineered ligaments and the discovery of minimal effective doses for tendon adaptation.[00:13:50] The refractory period between optimal tendon loading sessions.[00:16:42] Rapamycin's effects on muscle hypertrophy.[00:18:49] Protocols for tennis elbow rehabilitation.[00:20:28] Why isometrics work better than eccentrics for tendon healing.[00:22:14] Stress shielding and how load distribution affects tendon healing.[00:29:07] The misconception about eccentric loading for tendon injuries and why velocity matters.[00:29:58] Ideal duration for isometric holds (10-30 seconds) based on injury status.[00:33:50] My elbow issues and current rehab approach.[00:36:02] Overcoming vs. yielding isometrics and optimal loading strategies.[00:47:11] Dr. Barr's movement prescription for my tennis elbow.[00:52:18] Loading timing post-surgery and RICE protocol criticism.[00:56:58] Achilles tendon rehabilitation after surgery.[01:00:18] Critique of orthopedic suturing techniques and recommendation for resorbable sutures.[01:04:02] Multiple position isometrics for tennis elbow rehabilitation.[01:07:26] Collagen synthesis, supplementation, and vitamin C timing.[01:12:59] Critique of BPC-157 and other injectable peptides for tendon healing.[01:18:19] Evaluation of orthobiologics' (PRP, prolotherapy, stem cells) effectiveness.[01:21:37] JAK-STAT inhibitor drugs and their effects on tendon growth.[01:25:35] Drugs that increase risk of tendon ruptures (fluoroquinolones, AT-1 receptor drugs).[01:29:33] How estrogen affects tendon stiffness and injury risk in women.[01:32:48] Testosterone's opposite effects on tendon compared to estrogen.[01:35:31] Protein intake recommendations and timing.[01:40:11] Ketogenic diet effects on mitochondrial biogenesis and longevity.[01:41:57] Comparison of ketogenic diet, low protein diet, and rapamycin for longevity.[01:47:19] Inflammation's role in adaptation and when to reduce it.[01:51:17] Timing of ice baths relative to training for optimal recovery.[01:52:33] Parting thoughts.*For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim's email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim's books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissPast guests on The Tim Ferriss Show include Jerry Seinfeld, Hugh Jackman, Dr. Jane Goodall, LeBron James, Kevin Hart, Doris Kearns Goodwin, Jamie Foxx, Matthew McConaughey, Esther Perel, Elizabeth Gilbert, Terry Crews, Sia, Yuval Noah Harari, Malcolm Gladwell, Madeleine Albright, Cheryl Strayed, Jim Collins, Mary Karr, Maria Popova, Sam Harris, Michael Phelps, Bob Iger, Edward Norton, Arnold Schwarzenegger, Neil Strauss, Ken Burns, Maria Sharapova, Marc Andreessen, Neil Gaiman, Neil de Grasse Tyson, Jocko Willink, Daniel Ek, Kelly Slater, Dr. Peter Attia, Seth Godin, Howard Marks, Dr. Brené Brown, Eric Schmidt, Michael Lewis, Joe Gebbia, Michael Pollan, Dr. Jordan Peterson, Vince Vaughn, Brian Koppelman, Ramit Sethi, Dax Shepard, Tony Robbins, Jim Dethmer, Dan Harris, Ray Dalio, Naval Ravikant, Vitalik Buterin, Elizabeth Lesser, Amanda Palmer, Katie Haun, Sir Richard Branson, Chuck Palahniuk, Arianna Huffington, Reid Hoffman, Bill Burr, Whitney Cummings, Rick Rubin, Dr. Vivek Murthy, Darren Aronofsky, Margaret Atwood, Mark Zuckerberg, Peter Thiel, Dr. Gabor Maté, Anne Lamott, Sarah Silverman, Dr. Andrew Huberman, and many more.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Can You Mimic Fasting—Without Actually Fasting? Chris Rhodes, a biochemist and longevity researcher, joins Dave to reveal a groundbreaking fasting mimetic that could revolutionize how we approach aging, metabolism, and health. Fasting is one of the most powerful tools for longevity, but what if you could achieve the same benefits without hunger, energy crashes, or social sacrifices? Scientists have identified key compounds that mimic fasting at the cellular level—offering a way to extend lifespan, boost metabolism, and enhance cognitive function without giving up food. Enter Mimio, a blend of four key molecules naturally produced during fasting, is engineered to deliver the life-extending benefits of fasting—without starvation. For decades, fasting has been the gold standard for longevity, but over-fasting can wreck hormones, metabolism, and muscle mass. So, what if you could get the benefits of a 36-hour fast without the downsides? Chris breaks down the science behind fasting, autophagy, and the game-changing compounds that trick your body into entering a fasted state—even while eating. What You'll Learn: • The optimal fasting window for maximizing lifespan (Hint: It's not 16 hours) • The four fasting metabolites that extend life by 96% • How Mimio mimics fasting benefits—without giving up food • The real reason over-fasting destroys your metabolism and hormones • Why traditional longevity drugs (Metformin, Rapamycin) fall short • Can you build muscle and burn fat at the same time? The science of mTOR & AMPK • Why Big Pharma doesn't want you to know about this breakthrough *** Get 20% off Mimio at mimiohealth.sjv.io/3J9abX with code: DAVE *** Sponsors:Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial.Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order.Resources: • Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Mimio Instagram: https://www.instagram.com/mimiohealth/ • Mimio Website: https://mimiohealth.com/ • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey's Website: https://daveasprey.com • Dave Asprey's Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 – Intro • 00:58 – Fasting & Longevity • 01:88 – Optimal Fasting Length • 03:39 – Alternate Day Fasting: Pros & Cons • 05:50 – Key Fasting Compounds • 07:34 – Spermidine & Longevity Molecules • 11:41 – FDA Roadblocks on Natural Compounds • 15:37 – AI, Big Data & Longevity Research • 31:19 – Mimio's Impact on Testosterone & Aging • 35:16 – Longevity & Death Philosophy • 36:48 – Biohacking Origins • 37:03 – Metabolism & Cognitive Function • 38:35 – Unexpected Effects of Fasting • 40:43 – Fasting & Circadian Rhythms • 43:09 – Mimio Science & Benefits • 45:14 – Mimio in a Daily Routine • 55:05 – Men vs. Women: Fasting Differences • 01:02:23 – Future of Nutrition & Biohacking • 01:07:21 – Conclusion & Discount Code See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.