Podcast appearances and mentions of David Sinclair

Send us a textThe mountain running world turns its attention to Palisades Tahoe this week for what promises to be an epic showdown at the Broken Arrow 46K. This isn't just any race – it's a Team USA selection event that has attracted virtually every elite mountain runner in the country, creating what might be the most competitive field ever assembled on American soil.The race itself presents a formidable challenge: approximately 28 miles with a punishing 9,000 feet of vertical gain over two loops. Course record holder David Sinclair's time of roughly four hours could be under threat this year, with perfect weather conditions and extraordinary talent at the starting line. Unlike previous years where scorching heat played a factor, this year's forecast calls for cooler temperatures in the 60s, potentially setting the stage for blistering performances.What makes this race particularly fascinating is the strategic complexity surrounding Team USA selection. Several favorites, including Eli and Tabor Hemming, have indicated they may decline team spots even if they qualify, preferring to focus on European races like OCC and CCC. This creates a dynamic where some athletes are racing purely for personal achievement while others see this as their golden opportunity to represent their country internationally. With limited spots available and such depth of talent, expect fierce competition down to the final descent.The women's field features multiple former champions including Helen Mino Faulkner and Jennifer Lichter, with Grayson Murphy's potential participation looming large over the competition. On the men's side, Eli Hemming enters as the clear favorite after dominant performances this season, with Garrett Corcoran, David Norris, Brian Whitfield, and John Aziz among those battling for podium positions. For mountain running fans, Saturday's race represents a rare opportunity to witness America's best athletes pushing their limits on one of the sport's most challenging and prestigious courses.Follow James on IG - @jameslaurielloFollow the Steep Stuff Podcast on IG - @steepstuff_podUse code steepstuffpod for 25% off your cart at UltimateDirection.com! 

Join Sub Hub Podcast hosts Dani Moreno and Emkay Sullivan as they preview the 2025 Team USA Selection race happening this weekend at Sunapee Scramble in New Hampshire. This Six03 Endurance event was an incredible selection race for the 2023 USA Team.The course features a challenging 9.3-mile route with 3300 feet of elevation gain. Lap One begins with a 2.3-mile climb up the service road, gaining 1500 feet of ascent, followed by a fast 1.75-mile descent on ski trails. Lap Two covers 3.5 miles of total ascent, starting on the service road before transitioning to the technical Newbury Trail on the way to the summit, with 1800 feet of ascent. The descent for this lap is the same as the first.With Team Spots on the Line, the top competitors will secure their places on the US Mountain Running Team to compete at the World Mountain and Trail Running Championships in Canfranc, Spain, from September 25-28. For the men, the top 4 eligible runners will earn spots on the US team, while the top 3 eligible women will secure spots on the US Women's Mountain Running Team. Additionally, there is an auto-spot for Grayson Murphy (2023 World Champion).On the men's side, expect to see top contenders like Dan Curts, Andy Wacker, Christian Allen, Morgan Elliot, and David Sinclair, among others. The women's field features standout athletes such as Lauren Gregory, Allie McLaughlin, Rachel Tomajczyk, Anna Gibson, and more, promising two exciting races this Sunday.Tune in to the live stream here: https://www.youtube.com/watch?v=6vSY_7yh4dE

A gente vive mais, mas vive melhor? Esse foi o ponto de partida de uma palestra que virou obsessão da Ju — e deu origem a esse episódio do Mamilos. Dr. David Sinclair, geneticista de Harvard e uma das maiores referências em longevidade, fez a nossa cabeça ferver.. A promessa? Um futuro em que poderemos reverter o envelhecimento, restaurar a visão, recuperar memórias perdidas e viver com o corpo em estado de juventude por muito mais tempo. Parece ficção científica, mas as pesquisas estão avançando — e já deram resultados impressionantes em animais. Mas se a ciência ainda não entregou a pílula da juventude eterna, o que podemos fazer no presente para envelhecer com saúde, autonomia e qualidade de vida? A partir dessa provocação, o episódio mergulha numa conversa cheia de descobertas sobre os hábitos, escolhas e práticas que já estão ao nosso alcance e que fazem toda a diferença na forma como vivemos os nossos anos. Afinal, a forma como a gente dorme, come, se exercita, trabalha, se relaciona e até respira pode acelerar — ou desacelerar — o nosso envelhecimento. A boa notícia é que não se trata de seguir regras mirabolantes, mas de cultivar rotinas possíveis e consistentes, que respeitem o corpo e a mente como aliados no processo de envelhecer bem. Nesse episódio, não vendemos promessas milagrosas. Mas oferecemos um mapa: das descobertas mais futuristas às atitudes mais cotidianas, traçamos um caminho para quem quer viver mais e melhor — com lucidez, autonomia e prazer. Participam com a gente: Natália Gomes Gonçalves: Bióloga, professora do Departamento de Medicina Preventiva da Faculdade de Medicina da USP; Milton Crenitte: Médico geriatra, doutor em Ciências pela Faculdade de Medicina da USP (FMUSP) e Diretor Técnico do ILC-BR; Anuncie no Mamilos ou contrate a consultoria Milos: mamilos@mamilos.me Saiba mais em Mamilos.me

In this enlightening episode of the Neuroscience Meets Social and Emotional Learning podcast, we delve into groundbreaking territory with Dr. Fred Jordan, CEO and co-founder of Alt Vision and FinalSpark, as he joins us from Switzerland. Dr. Jordan introduces us to a revolutionary emerging technology where living neurons—nature's own processors—are set to transform the landscape of technology and artificial intelligence. Explore how bioprocessors, derived from human stem cells using advanced lab techniques, could potentially outperform traditional semiconductor devices by significantly reducing power consumption, particularly in AI computations. Understand the implications of such innovations and the ethical considerations they entail, as we navigate a future where biocomputers might fundamentally alter our technological capabilities. Join us in opening our minds to the possibilities of neuroscience-driven tech advancements, as we discuss the practical applications and visionary future that Dr. Jordan and his team are shaping, inviting curiosity and critical thinking into our evolving technological world. Watch our Interview on YouTube here https://www.youtube.com/watch?v=8D3eKkd3L4w For today's episode #363, we meet with Dr Fred Jordan, where we looked at: ✔ What is the biocomputer? ✔ What does this NEW innovative technology, make obsolete, from our past? ✔ What are the benefits of a biocomputer, and how exactly does it work? ✔ What is the vision of FinalSpark, and how can this change the future of AI? Welcome back to SEASON 13 of The Neuroscience Meets Social and Emotional Learning Podcast, where we connect the science-based evidence behind social and emotional learning and emotional intelligence training for improved well-being, achievement, productivity and results—using what I saw as the missing link (since we weren't taught this when we were growing up in school), the application of practical neuroscience. I'm Andrea Samadi, an author, and an educator with a passion for learning and launched this podcast 7 years ago now, with the goal of bringing ALL the leading experts together (in one place) to help us to APPLY this research in our daily lives. For today's episode #363, we meet with the CEO and Co-Founder of AlpVision and FinalSpark, Dr. Fred Jordan who will be joining us all the way from Switzerland. I met Dr. Jordan through LinkedIn, where he introduced his work to me, and my attention was caught. When I asked him what he does in his lab at FinalSpark, he wrote back to me that his lab has developed an emerging technology that would redefine the status quo in technology and in the ways that people work. Of course I asked him if he could explain this to me, and he wrote back that “we use living neurons, the building blocks in the brain, for processing information” and sent me the link to his website[i] where there is a live camera view of living neurons placed on electrodes, and you can see the signal from them. He went on to explain that neurons in the brain communicate using electrical and chemical stimulations and that his lab was focused on building a new generation of bioprocessors. At this point, I am sure he would know that I'm interested to learn more, mostly to understand what exactly does this mean? I wonder: Does Dr. Jordan mean that his lab is building a computer processor out of living neurons (cells from our brain)? How do they do this? What are the advantages of a bioprocessor vs using transistors (that are semiconductor devices used to amplify or switch electrical signals and power)? How does this connect to AI? What does his lab envision for the future? I have a lot of questions for Dr. Jordan, and I am coming from the point of view that I really want to learn and understand what his lab has created. I want to be able to explain his idea to our audience in a way that we can all come away with some new knowledge and understanding about the future, and how keeping an open mind while learning can set us apart from others, and even give us a razor's edge advantage in whatever work we are doing in the world. Let's meet Dr. Fred Jordan, and together, learn about the work they are doing at FinalSpark in Switzerland, and see if it can expand of thinking, and take us to new heights with the new awareness we will gain today. INTRO Q: Welcome Dr. Fred Jordan. Thank you for reaching out to me, and opening up my mind to something that while writing these questions, I still didn't completely understand. Can you explain what exactly is a biocomputer and why would anyone want to have a computer that uses living neurons instead of transistors to process information? Q1: As someone who loves entrepreneurship, or those people in the world who create new ideas that change the world, can you tell me how where this idea began? Q2: I did listen to one of your podcast episodes[ii] about “The Future of AI: How Biocomputers Will Change Everything” so I could wrap my head around what you do at FinalSpark, and it brought me to something I heard longevity researcher Dr. David Sinclair say that I will never forget. He said “we can make a mouse in a lab out of stem cells.” Can you explain where these neurons come that you are using come from and also help me to understand what Dr. Sinclair meant when he said they can make a mouse out of stem cells? Q3: For someone who doesn't have a formal background in science, but I want to learn difficult concepts, and be able to explain them to others, can you explain how these living neurons work? Q4: What is the advantage of using a biocomputer and what problems does this solve? They consume 1 million X less than digital computers, quantum computers still in R&D stage Q5: What industries will be changed with the biocomputer? (semi-conductor industry) or what other applications can you think of that this type of computer can have (maybe medical applications)? Q6: What types of feedback are you hearing about the biocomputer? Do people think it's acceptable to use living neurons for computation? Q7: Who are the leaders in this type of research? What other countries do you know of, where labs are working on this type of computer? Q8: What Universities have approached you to learn more about this neuro-platform? Q9: What is your vision for FinalSpark, and how do you think this will change the future workforce? Q10: This topic made me think and I found it difficult to grasp, but am very interested in learning more about how this concept could change everything that we know about the way we work and use computers. What would you say to me to show me that having an open mind will set me apart from others, or give me an advantage maybe in the future? Q11: Is there anything I have missed, or anything important that our listeners should know about?  Dr. Jordan, I want to thank you for taking the time to speak with me about what you have created at FinalSpark. I'm very interested in NEW ideas, especially those that will change the way we operate and live our lives, exponentially. I remember hearing a quote from Gordon Moore, Intel's co-founder and the author of Moore's law many years ago in reference to the fact that “the number of transistors in an integrated circuit doubles roughly every 2 years” and this trend has driven the exponential growth of computing power and efficiency , leading to faster processors and smaller devices. He said “frankly, I didn't expect to be so precise” with his prediction. What do you think when you have the power of the biocomputer, and George Moore's quote, of the potential of what you have created at FinalSpark? For people to connect with you and learn more, what is the best way? CONNECT with Dr. Fred Jordan   LinkedIn https://www.linkedin.com/in/fred-jordan-anticounterfeiting-brandprotection-authentication/   REFERENCES:   [i] https://finalspark.com/live/   [ii] Dr. Fred Jordan on the Future of AI: How Bio-Computers Will Change Everything https://podcasts.apple.com/us/podcast/season-5-ep1-dr-fred-jordan-co-founder-of-finalspark/id1756198461?i=1000686503506    

➡️ Join 321,000 people who read my free weekly newsletter: https://newsletter.scottdclary.com➡️ Like The Podcast? Leave A Rating: https://ratethispodcast.com/successstoryDr. Kyle Landry is the President and Co-Founder of Delavie Sciences, a skincare company dedicated to developing innovative, science-backed products. He earned his Master's and Ph.D. in Food Science from the University of Massachusetts Amherst. Dr. Landry conducted postdoctoral research on extremophiles—organisms that thrive in extreme environments—at Harvard Medical School under the mentorship of Dr. David Sinclair. Their collaboration led to a partnership with government space agencies to address challenges associated with long-duration space travel, resulting in the discovery of novel extremophiles, including Bacillus Lysate. This research inspired the founding of Delavie Sciences, aiming to tackle common skin concerns, particularly aging.➡️ Show Linkshttps://www.instagram.com/kylelandryphd/https://www.linkedin.com/in/kyle-landry-phd-44513a40/ https://www.delaviesciences.com/ ➡️ Podcast SponsorsHubspot - https://hubspot.com/ Delavie Sciences - https://www.delaviesciences.com/ (Code: Success for 25% off on all products *not including bundles or the flex wand)Vanta - https://www.vanta.com/scott Federated Computer - https://www.federated.computer Cornbread Hemp - https://cornbreadhemp.com/success (Code: Success)Create Like The Greats Podcast - https://podcasts.apple.com/lu/podcast/create-like-the-greats/id1653650073 FreshBooks - https://www.freshbooks.com/pricing-offer/ Bank On Yourself - https://www.bankonyourself.com/scott Stash - https://get.stash.com/successstory NetSuite — https://netsuite.com/scottclary/ Indeed - https://indeed.com/clary➡️ Talking Points00:00 - Intro05:11 - Kyle's Journey & Origin Story10:28 - Alternate Career Paths13:00 - Solving Big Problems with Food Science16:32 - Shocking Food Realities20:53 - The Bean Sprout Breakthrough26:52 - Reinventing Sunscreen31:37 - A Scientist's Daily Routine35:11 - NASA-Level Bean Sprouts42:30 - Health & Fitness Hacks45:58 - Sponsor Break48:36 - Supplement Industry Secrets56:39 - Must-Have Skincare Ingredients59:52 - Hidden Dangers in Ingredients1:09:25 - Challenges in Launching New Research1:13:41 - Where to Invest Time & Energy1:15:54 - Sponsor Break1:18:06 - Advice for Ambitious Entrepreneurs1:26:36 - Kyle's Weakness as an Entrepreneur1:28:33 - Facing Imposter Syndrome1:31:06 - Balancing Work & Family2:00:00 - Breaking Out as an Artist2:08:28 - Kyle's Ultimate Life LessonSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Exklusives Coaching und Webinare mit Dr. Bredehorst: https://cellsciencepodcast.de/Dr. Kay Bredehorst über Bryan Johnson und David Sinclair und was wirklich dran ist.mTOR, Sirt Gene und Longevity sindBioverfügbares Kurkuma: https://mitocare.de/products/lipo-curcumin-boosterCode: V60014Achtung: Iss Getreide, Hülsenfrüchte oder Mais niemals roh. Die besten Ernährungstipps für einen gesunden Darm und warum Kurkuma zu 99% nicht aufgenommen wird, erfährst du in diesem Video.Inhaltsverzeichnis:00:00 Intro04:30 Vorteile pflanzlicher Ernährung07:20 SIRT - Zellen die ständig im Betrieb sind, gehen kaputt10:30 Fasten13:00 NMN ist Novel Food (In Deutschland verboten!!)15:00 NAD wird hier genutzt. SIRT arbeitet danach schneller19:00 mTOR POWER (Zucker und Protein)22:30 Gesunde Lebensmittel und sekundäre Pflanzenstoffe29:30 AMPK Gen und Bewegung34:30 RegenerationsphasenMehr Infos zu ….–Mehr von Mr. Broccoli:Homepage: https://www.vegan-athletes.comAbonniere meinen YouTube Kanal: https://www.youtube.com/@mrbroccoliInstagram: https://www.instagram.com/mrbroccoli.official/Telegram (für besonders brisante Themen): https://t.me/mrbroccoli_veganNewsletter: https://www.vegan-athletes.com/newsletter-vegan-athletes/➤➤➤ Meine 10 Favoriten für mehr Gesundheit: https://www.vegan-athletes.com/empfehlungen/

Send us a textWhat does it take to transform from a competitive tennis player into one of trail running's most exciting uphill specialists? Remy Leroux shares his remarkable journey with refreshing candor and scientific precision in this wide-ranging conversation about the evolution of mountain running.Fresh off his impressive third-place finish at the Big Alta 50K against elite competition, Remy opens up about finding running after his tennis career ended at age 19. Without the traditional track background of many elites, he's carved out a unique path to success through methodical training and race analysis. His approach to the sport combines meticulous preparation with genuine passion – monitoring heart rate variability before races to determine his caffeine intake and music selection, while remaining childlike in his enthusiasm for exploring endless dirt roads during Quebec's harsh winters.Remy's recent signing with Brooks reflects the growing investment in sub-ultra mountain running, joining a stacked roster of specialists in a discipline that's gaining momentum in North America. He offers fascinating insights into the differences between European and American race cultures, revealing why standardized courses and distinct race categorizations might help sub-ultra racing gain the popularity it enjoys overseas.What makes Remy particularly compelling is his specialized uphill ability – twice defeating mountain running legend David Sinclair – combined with his analytical approach to improvement. He breaks down his race strategy for iconic events like Broken Arrow and Sierra-Zinal with the precision of someone who studies every aspect of his craft while maintaining genuine joy in the process.Ready to discover what separates ultra from sub-ultra racing psychology and why the latter might provide more thrilling competition? Listen now and follow Remy's journey as he prepares to represent Canada at the World Mountain Running Championships and take on the Golden Trail Series against the world's best.Follow Remi Leroux on IG - @remi_leroux_Follow Remi Leroux on Youtube - @RemiLerouxFollow James on IG - @jameslaurielloFollow the Steep Stuff Podcast on IG - @steepstuff_podThis episode is proudly supported by Ultimate Direction. Head over to UltimateDirection.com to check out UD's new Race Vest 6L & Ultra Vest 12L packs that just dropped last week ! Use code steepstuffpod for 25% off ! 

David Sinclair is a professional trail runner and ski mountaineer based in Vermont. David recently signed a contract with Craft Sportswear following a phenomenal 2024. David won and broke the course records at Broken Arrow 46K, Speedgoat 50K and JFK 50 Mile last year. We talk with David about transitioning to becoming a full time athlete, his upcoming ski mountaineering season and what he plans to do in 2025. Follow David:⁠Instagram: @david.a.sinclair.92Follow us:Instagram:⁠⁠ @emkaysulli ⁠⁠| ⁠⁠@dan_yell_a⁠⁠Podcast: ⁠⁠@the_subhub_pod⁠⁠ Episode Sponsors:Neversecond: Use code SUBHUB25 for 25% off your purchase-- ⁠⁠never2.com⁠⁠Beekeepers Natural: Use code SUBHUB20 for 20% off your purchase-- ⁠⁠www.beekeepersnaturals.com⁠⁠Pit Viper:⁠⁠⁠⁠Click this link for 20% off at checkout

Matt previews public hearings for the week of March 10, 2025.LD 369, SP0161An Act to Grant or Extend Conditional Teaching Certificates Under Certain Circumstances - Sen. James Libby of CumberlandLD 470, SP0209An Act to Require School Administrative Units to Adopt Mentoring Programs for Teachers and to Improve Existing Programs - Sen. Joseph Rafferty of YorkLD 696, SP0313An Act to Bolster the Maine Teacher Residency Program - Sen. Teresa Pierce of CumberlandLD 734, HP0476An Act to Promote Voter Registration for Students in Maine's High Schools - Rep. Julie McCabe of LewistonLD 220, HP0143An Act to Establish the Hope and Inclusion Scholarship Program in Order to Provide Funding for Students Attending Certain Private Schools and Students Receiving Home Instruction - Rep. Barbara Bagshaw of WindhamLD 282, HP0182An Act to Raise the Limit on the Total Number of Public Charter Schools - Rep. Gary Drinkwater of MilfordLD 420, HP0274An Act to Fund the Carleton Project to Provide Additional Access to a Nontraditional Secondary School - Rep. Gregg Swallow of HoultonLD 482, HP0311An Act to Expand Educational Opportunities and Broaden Educational Services for Students Enrolled in Equivalent Instruction Programs - Rep. Barbara Bagshaw of WindhamLD 512, SP0230An Act to Provide Educational Opportunities for Students in Secondary Schools with 200 or Fewer Students - Sen. Stacey Guerin of PenobscotLD 21, SP0034An Act to Update the Provision of Law Concerning Student Codes of Conduct in Order to Reflect Best Practices Regarding Behavioral Threat Assessment and Response - Sen. Joseph Rafferty of YorkLD 168, HP0101An Act to Improve Safety in Public Schools by Requiring Silent Electronic Notification Systems in Classrooms - Rep. David Sinclair of BathLD 808, HP0515An Act to Require School Boards and Governing Bodies of Approved Private Schools to Implement Wearable Panic Alert Systems - Rep. Anne-Marie Mastraccio of Sanford1:00 pm Public HearingLD 165, HP0098An Act to Allow School Boards to Expel or Suspend Students Regardless of Grade Level - Rep. Will Tuell of East MachiasLD 513, SP0232An Act to Allow the Spouse of a School Board Member to Serve as a Stipend Employee Within the School Board's Jurisdiction - Sen. Marianne Moore of WashingtonLD 817, HP0524An Act to Remove Restrictions That Prohibit School Administrative Units from Making Purchases Through Cooperatives - Rep. Christina Mitchell of Cumberland

It's likely different from your chronological age. And it has a huge impact on how long you're going to live. You learn that your lifespan is determined 80% by your lifestyle choices, 20% by your genetics. Learn the power of metformin as a longevity drug. Also the power of Resveratrol.

In this interview, Andrea Donsky, nutritionist, menopause educator, published menopause research, and co-founder of wearemorphus.com explores the topics of healthspan and lifespan with special guest Chris Burris. Chris is a published author and founder of My Vital C.He shares insights from his extensive research and interviews with 55 longevity, including the critical roles of sleep, diet, exercise, and mindset in extending life quality and lifespan.Chris discusses his entrepreneurial journey to developing supplements that may support better health and longevity. Whether you're in perimenopause, menopause, or simply interested in living a healthier, longer life, this episode is packed with valuable tips and breakthroughs. Don't miss it!Topics Covered: The importance of healthspan and lifespan and how mindset plays a key role in determining the behaviors that can improve outcomes. Why sleep is on the list for many biohacking experts. There are no silver bullets or easy answers regarding healthspan, but many lifestyle and nutrition choices can be made to enhance it.The unexpected benefits of carbon molecules and how to integrate them daily.The science behind ESS 60 and how it is safe for human consumption.Carbon has many benefits, including inflammation from overtraining or over-exertion, and its antioxidant properties.The future of carbon science, research, and human studies. Conclusion and final thoughtsBooks Mentioned:Live Longer and Better: Your Journey to Living Longer and Better Has Never Been More Achievable Than Today by Chris Burres: https://amzn.to/41pDF3RLifespan: Why We Age – and Why We Don't Have To by Dr. David Sinclair: https://amzn.to/4k6xgTmWhy We Sleep: Unlocking the Power of Sleep and Dreams by Dr. Matthew Walker: https://amzn.to/4k5EgjtMyVitalC https://bit.ly/3EQ9bAf save 15% with CODE MORPHUS15Send us a text ✅ Fill out our surveys Support our SPONSORS: Qualia https://bit.ly/42mtvmx CODE MORPHUS15 BEAM Minerals https://bit.ly/41DCG1w Code MORPHUS EnergyBits https://bit.ly/49f05YV Code MORPHUS Livon: https://bit.ly/3EjrcGG CODE MORPHUS Order 1 carton of Lypo-Spheric® Vitamin C at LivOnLabs.com & get 1 carton of B Complex Plus FREE ($56 value) just by adding both products to the cart Timeline: timeline.com/morphus CODE MORPHUS MyVitalC https://bit.ly/3EQ9bAf CODE MORPHUS15

This is a replay of a preview taken from our sister podcast Brave New World. Is it possible to live forever – and would you even want to? Evgeny Lebedev is joined by David Walliams to explore the science and ethics of age reversal. He also meets longevity pioneer Dr David Sinclair, who gives advice on how to extend lifespans - and tells David Walliams how to reverse his biological clock.To hear the whole episode search 'Brave New World Evening Standard' on your podcast provider. Hosted on Acast. See acast.com/privacy for more information.

We're getting deeper into our series on Aging Reversed. As I say at the beginning of every episode, my goal is to live a long, healthy, happy, active life right up to the end. This year I want to focus more on these simple topics and this series is about the "long" part. I take my inspiration from the book "Lifespan" by David Sinclair, which, if you have the stomach for some deep technical stuff, I recommend you read. The theory is that aging can be halted, or even turned in reverse, if we devote enough resources to the effort. That's what this series is trying to decode for you. Read the full post at http://RunningAFEVER.com/390  

A Note from James: I've done about a dozen podcasts in the past few years about anti-aging and longevity—how to live to be 10,000 years old or whatever. Some great episodes with Brian Johnson (who spends $2 million a year trying to reverse his aging), David Sinclair (author of Lifespan and one of the top scientists researching aging), and even Tony Robbins and Peter Diamandis, who co-wrote Life Force. But Peter just did something incredible. He wrote The Longevity Guidebook, which is basically the ultimate summary of everything we know about anti-aging. If he hadn't done it, I was tempted to, but he knows everything there is to know on the subject. He's even sponsoring a $101 million XPRIZE for reversing aging, with 600 teams competing, so he has direct insight into the best, cutting-edge research. In this episode, we break down longevity strategies into three categories: common sense (stuff you already know), unconventional methods (less obvious but promising), and the future (what's coming next). And honestly, some of it is wild—like whether we can reach "escape velocity," where science extends life faster than we age. Peter's book lays out exactly what's possible, what we can do today, and what's coming. So let's get into it. Episode Description: Peter Diamandis joins James to talk about the future of human longevity. With advancements in AI, biotech, and medicine, Peter believes we're on the verge of a health revolution that could drastically extend our lifespans. He shares insights from his latest book, The Longevity Guidebook, and discusses why mindset plays a critical role in aging well. They also discuss cutting-edge developments like whole-body scans for early disease detection, upcoming longevity treatments, and how AI is accelerating medical breakthroughs. Peter even talks about his $101 million XPRIZE for reversing aging, with over 600 teams competing. If you want to live longer and healthier, this is an episode you can't afford to miss. What You'll Learn: Why mindset is a crucial factor in longevity and health The latest advancements in early disease detection and preventative medicine How AI and biotech are accelerating anti-aging breakthroughs What the $101 million XPRIZE is doing to push longevity science forward The importance of continuous health monitoring and personalized medicine Timestamped Chapters: [00:01:30] Introduction to Anti-Aging and Longevity [00:03:18] Interview Start – James and Peter talk about skiing and mindset [00:06:32] How mindset influences longevity and health [00:09:37] The future of health and the concept of longevity escape velocity [00:14:08] Breaking down common sense vs. non-common sense longevity strategies [00:19:00] The importance of early disease detection and whole-body scans [00:25:35] Why insurance companies don't cover preventative health measures [00:31:00] The role of AI in diagnosing and preventing diseases [00:36:27] How Fountain Life is changing personalized healthcare [00:41:00] Supplements, treatments, and the future of longevity drugs [00:50:12] Peter's $101 million XPRIZE and its impact on longevity research [00:56:26] The future of healthspan and whether we can stop aging [01:03:07] Peter's personal longevity routine and final thoughts Additional Resources:

Are You Making the #1 Mistake That's Holding Back Your Growth? In this episode, I'm joined by some of the brightest minds in business and entrepreneurship to tackle one of the most common challenges: the critical mistake entrepreneurs make that stunts their success. Featuring Marc Randolph, Gunnar Peterson, Billy Gene, David Novak, and David Sinclair, this episode is packed with transformative lessons you can implement immediately to grow your business and yourself. Marc Randolph, the co-founder of Netflix, shares his insights on embracing failure and falling in love with the problem, not the solution. His story about testing ideas quickly and creatively—like mailing a CD to prove Netflix's original concept—will inspire you to take bold, decisive action without overthinking. Gunnar Peterson brings his unique perspective from the fitness industry, emphasizing how every interaction with a customer or client is an opportunity to create a positive experience they'll remember. Billy Gene explains his journey from struggling entrepreneur to marketing guru, highlighting how ignorance and arrogance can derail your business. His raw and relatable stories of early mistakes remind us of the importance of learning from others and embracing humility. David Novak dives into the art of leadership, explaining the concept of managing "two up and two down" to ensure you're building strong relationships with your team and the higher-ups who can influence your career. Finally, David Sinclair offers a glimpse into the future of longevity and how entrepreneurs can position themselves in emerging industries by focusing on trends and surrounding themselves with exceptional people. Key Takeaways: - Fail Forward: Learn how to treat failure as a stepping stone rather than a setback. - Client Experience Matters: Gunnar's advice on making every customer interaction exceptional. - Learn Before You Leap: Billy Gene's journey underscores the value of mentorship and humility. - Lead with Vision: David Novak's strategies for managing relationships and motivating teams. - Future-Proof Your Business: David Sinclair's insights on trends and innovation in emerging industries. As entrepreneurs, the choices we make every day determine the trajectory of our businesses. This conversation is your blueprint for identifying and correcting the mistakes that may be holding you back. Don't just listen—apply these lessons and watch your business thrive. Let's take your growth to the next level. You're capable of more than you realize. Thank you for watching this video—Please Share it and get the word out! What part of this video resonated with you the most? Comment below! Learn more about your ad choices. Visit podcastchoices.com/adchoices

In this special episode, Jeff Garmire and Derrick Lytle bring the laughs with The Jeffrey Awards—trail running's greatest trophy! Join us as we hilariously crown winners in outrageous categories celebrating the best, worst, and downright weirdest moments of the trail running and ultra community. Support us on Patreon. Patreon.com/freeoutside

Hoy vamos a hablar de cómo podría ser ese futuro gracias a las investigaciones del profesor David Sinclair, de la Universidad de Harvard, quien sostiene que el envejecimiento no solo puede ralentizarse, ¡sino incluso revertirse! ¿Te imaginas un futuro donde envejecer ya no sea una barrera para disfrutar la vida al máximo? Donde puedas mantenerte joven, fuerte y lleno de energía durante más años. Por otro lado, aquí está te dejo un regalo para Transformar tu 2025: ¿Estás listo para transformar tu vida en 7 pasos?

Send us a textTrail running enthusiasts and adventure seekers, you're in for a treat! Join us as we chat with the phenomenal David Sinclair, a mountain running and ski mountaineering powerhouse who has been making waves with his record-breaking performances. Discover the secrets behind his awe-inspiring run at the JFK 50 and his ambitions for the ski mountaineering season as the 2026 Olympic cycle approaches. David opens up about the strategic choices that have shaped his career, including his move back to Vermont to fully commit to his athletic pursuits.Explore the dual sporting world of David Sinclair as he shares his journey from competitive cross-country skiing to dominating the ultra-running and ski mountaineering scenes. Hear firsthand how he transitioned from a coaching role in California to focus entirely on his athletic career, leading to impressive achievements at events like the Broken Arrow Skyrace and Speedgoat. David's unique training methods, which involve balancing high-altitude skiing with reduced running mileage, offer fascinating insights into the crossover success of skiers in the world of ultra-running.What drives a champion? David Sinclair's competitive mindset offers a glimpse into what it takes to excel at both ultra distances and ski racing. Learn about his thoughts on competing against some of the world's top athletes and his aspirations for Olympic participation in ski mountaineering. As you listen to this episode, you'll be inspired by David's dedication to pushing the boundaries of mountain sports, and you'll gain valuable takeaways on balancing performance with the joy of adventure. Don't miss this chance to get inside the mind of a true mountain legend!David Sinclair - https://www.instagram.com/david.a.sinclair.92/?hl=en

On this episode of The Kara Goldin Show, I'm joined by Dr. Kyle Landry, Co-Founder and President of Delavie Sciences, a brand on a mission to revolutionize skincare through cutting-edge science. Their first product, Aeonia, is terrific and uses Bacillus Lysate, a groundbreaking skincare ingredient that's making waves in the beauty industry for its age-defying properties.In our conversation, Dr. Landry shares his journey from academia to entrepreneurship, his partnership with renowned scientist Dr. David Sinclair, and the rigorous research and testing that went into developing Delavie's signature ingredient. We discuss the future of skincare, the role of science in developing truly innovative products, and how Delavie Sciences is poised to disrupt the skincare market with its commitment to transparency and proven results. If you're interested in the intersection of science, skincare, and innovation, this is an episode you won't want to miss. Tune in now on The Kara Goldin Show! Are you interested in sponsoring and advertising on The Kara Goldin Show, which is now in the Top 1% of Entrepreneur podcasts in the world? Let me know by contacting me at karagoldin@gmail.com. You can also find me @‌KaraGoldin on all networks. The Delavie Sciences team is giving listeners of The Kara Goldin Show a special discount. Use code KARA15 for 15% off your order at checkout!To learn more about Dr. Kyle Landry and Delavie Sciences:https://www.linkedin.com/company/delavie-sciences/https://www.instagram.com/delaviesciences/https://www.delaviesciences.com/ Sponsored By:ShipStation - Get a 60-day free trial at ShipStation.com/KARA. Thanks to ShipStation for sponsoring The Kara Goldin Show!Shopify - Sign up for your one-dollar-per-month trial period at Shopify.com/karaGrammarly - Head to Grammarly.com/enterprise to learn more about Grammarly Enterprise-ready AI. Check out our website to view this episode's show notes: https://karagoldin.com/podcast/620

We brought some joyful and fluid-tastic vibes to this great episode! The main topic involved us picking our jaws off the floor as records were absolutely annihilated at the JFK 50 Mile, America's oldest ultramarathon. We have some inside info on how David Sinclair set the record, which we think could be Ultra Performance of the Year. Plus we worship the queen, Rachel Drake. Why are we seeing record after record get smashed at every major race? The answer likely lies at the intersection of training, shoes, and most of all--fueling. We also talked about a breakthrough new study from the Boston Marathon. Researchers found that the prevalence of low energy availability indicators was associated with worse performance and health outcomes. Find your strong, and you will find your fast! And this one was full of fun topics! Other topics: David recording through fluid adversity, Megan taking one for the team because she loves the podcast mornings, the "Shoot Your Shot" mini-documentary on the Javelina 100, the frontiers of lubrication, lessons from Ryan Sullivan's incredible long-term progression, Shelby Houlihan returning from her ban, why we want to uplift forgiveness, a question on embracing competition, and Listener Corner. We love you all! HUZZAH! Click "Claim Reward" for $80 at The Feed here: thefeed.com/swap Buy a "SLURP" hat: https://thefeed.com/products/the-feed-some-work-all-play-hat Watch the "Shoot Your Shot" mini-documentary: https://www.youtube.com/watch?v=5pzUKGEmvqk Buy Janji's amazing gear: https://janji.com/ (code "SWAP") For weekly bonus podcasts, articles, and videos (plus hat purchases): patreon.com/swap

David Sinclair may have a case for Trail Runner of the Year after the most impressive race of the year. He broke the course record at JFK 50 miler. This is a race that Jim Walmsley, Adam Peterman, and Zach Miller have run, and he broke Hayden Hawks record by 10 minutes! We discuss his race strategy, the importance of nutrition, and the unique challenges of transitioning between trail and road shoes. Sinclair reflects on his journey to recognition and sponsorship in the ultra-running community, balancing his passions for skiing and trail running. He emphasizes the significance of strength training and shares insights into his training regimen. The conversation also touches on the distinct challenges of East Coast trails compared to their West Coast counterparts, the role of heat training in performance, and his aspirations for the future. Sound Bites "Winning the JFK 50 was surreal for me." "Grit and resilience define my journey." takeaways David Sinclair set a course record at the JFK 50 miler. He emphasizes the importance of head-to-head competition over time goals. Transitioning between trail and road shoes is a unique challenge. Nutrition planning is crucial for long races. Winning the JFK 50 was a surreal experience for Sinclair. Recognition and sponsorship in ultra running can be slow to come. Balancing skiing and trail running is a key focus for Sinclair. Strength training plays a significant role in his training regimen. Sinclair aims for Olympic aspirations in ski mountaineering. East Coast trails present unique challenges compared to West Coast trails. Chapters 00:00 David Sinclair's JFK 50 Victory and Course Record 07:55 Transitioning Between Trail and Road Shoes 13:45 The Thrill of Winning and Breaking Records 19:28 Navigating Sponsorship and Career Decisions 24:57 The Road to the Olympics and Team Dynamics 33:53 Overcoming Challenges in Competition 40:42 Training Structure and Recovery 45:42 Threshold Workouts and Race Preparation 51:28 Heat Training and Its Benefits 57:25 Weekly Mileage and Training Volume keywords: David Sinclair, JFK 50, ultra running, race strategy, nutrition, sponsorship, trail running, skiing, training regimen, strength training

With special guest: David Sinclair PhD AO… in conversation with Bill Kable Lifespan: Why We Age – and Why We Don’t Have To is a visionary book in a fast moving field. In fact when we talk to Dr David Sinclair for today’s program we discover that there have been some amazing developments in the scientific research of aging even since the book was written. The immediate response of some people to aging research is that death at a certain age is the natural order of things. Perhaps you might hear that someone has had a look at old age and now does not want to lengthen this time in that person’s life. But would we want to go back to the time not so long ago when life expectancy was more like 40 than the current 80? What if by controlling aging we could reduce rather than extend time spent in total dependency in a nursing home? Podcast (mp3)

Aging (Aging-US) was a proud sponsor of the “Future of Aging Research Mixer 2024” hosted by the Aging Initiative at Harvard University on November 15 in Boston. This event united a vibrant community of students, researchers and technologists, all driven by a shared mission: advancing innovations in aging research and longevity science. Key Highlights from the Future of Aging Research Mixer 2024 The event kicked off with inspiring opening remarks and a keynote by George Church, professor at Harvard Medical School, founding member of the Wyss Institute, and co-founder of over 50 biotech companies. He was joined by Kat Kajderowicz, an MIT PhD student and Principal at age1. Together, they highlighted the interdisciplinary nature of aging research and its immense potential to drive transformative advancements. Jesse Poganik, HMS Instructor in Medicine and Executive Co-Director of the Biomarkers of Aging Consortium, discussed the evolution of aging science and the critical role biomarkers play in understanding aging processes and assessing the effectiveness of interventions aimed at slowing or reversing age-related changes. Alex Colville, co-founder and general partner at age1, explained how venture capital can accelerate innovation in longevity biotechnology. He shared career advice for aspiring researchers and paid tribute to his mentor, Dr. David Sinclair, a pioneer in aging research. These talks highlighted the importance of mentorship, interdisciplinary collaboration, and investment in driving progress in the aging research field. Read the full summary - https://aging-us.org/2024/11/agings-commitment-to-advancing-research-sponsoring-the-future-of-aging-research-mixer/ About Aging-US The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population. The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.) Please visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Is biohacking your sweat the secret to vitality? Dave Asprey dives into the transformative world of infrared saunas with Connie Zak, founder of Sunlighten and a 25-year innovator in the space. Together, they uncover how targeted light and heat therapy can unlock unparalleled health benefits, from detoxing heavy metals to energizing your body at the cellular level. Here's what you'll learn in this episode: • Why infrared saunas excel at detoxing heavy metals and toxins • How they mimic exercise to boost cardiovascular health and recovery • The science behind infrared's impact on mitochondrial energy and longevity • Surprising benefits for gut health, inflammation, and hormone balance • Hacks to get the most out of your infrared sauna sessions Connie shares cutting-edge research and personal insights, offering practical ways to integrate infrared therapy into your routine. Whether you're looking to recover faster, improve your mood, or support long-term health, this episode delivers the tools you need to take your biohacking game to the next level. Special Offer: Use code “DAVE” at sunlighten.com to get up to $1,000 off until December 6th! Sponsors:-ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order. -fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. Resources: • Sunlighten Saunas Website – https://www.sunlighten.com/dave/?utm_source=DaveAsprey&utm_medium=Partner&utm_content=Podcast&leadsource=DaveAsprey&utm_campaign=DaveAsprey • Sunlighten Saunas on Instagram – https://www.instagram.com/sunlightensaunas/ • 2025 Biohacking Conference – https://biohackingconference.com/2025 • Dave Asprey's Website – https://daveasprey.com • Dave Asprey's Book: Smarter Not Harder – https://daveasprey.com/books • Danger Coffee – https://dangercoffee.com • Danger Coffee Instagram – https://www.instagram.com/dangercoffeeofficial/ • Dave Asprey's Linktree – https://linktr.ee/daveasprey • Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com • Own an Upgrade Labs – https://ownanupgradelabs.com • Upgrade Labs – https://upgradelabs.com • 40 Years of Zen – Neurofeedback training for advanced cognitive enhancement – https://40yearsofzen.com Timestamps • 00:00 Introduction to Infrared Saunas • 00:27 Meet Connie Zak: Leading Voice in Infrared Saunas • 00:50 The Science Behind Infrared Saunas • 02:35 Infrared Saunas vs. Traditional Saunas • 05:41 Health Benefits of Infrared Saunas • 08:14 Technological Advancements in Infrared Saunas • 17:36 The Role of LEDs in Infrared Saunas • 22:37 Practical Tips and Personal Experiences • 28:14 Detoxing and Energizing with Glutathione • 28:40 Pre and Post-Sauna Rituals • 29:05 Habit Stacking in the Sauna • 29:41 Managing Overheating Devices • 31:05 Creative Breakthroughs in the Sauna • 32:14 Scientific Method and Personal Experience • 36:05 Understanding Glucose Spikes • 38:44 Longevity Benefits of Infrared Saunas • 43:27 Infrared Saunas and Skin Health • 45:29 Extreme Detox Protocols • 48:28 Grip Strength and Longevity • 50:34 Customizing Your Sauna Experience See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Why are we so obsessed with trying to live forever? This week, special guest Chandler Saunders joins Jess and Joey to talk about adult superlatives, aging, the soul, compounding experience, afterlife FOMO, and aging reversal. They don't talk about Irene Cara. references Piaget's 4 Stages of Cognitive Development Explained Ray Kurzweil Ship of Theseus Fermi paradox Spin by Robert Charles Wilson Kardashev scale Telomere Dr. David Sinclair 

Josie Fisher and David Sinclair are mountain athletes based out of New Hampshire and Vermont. They are each incredibly accomplished in both the mountain running and skimo worlds, and they threw down great times during the Run the Whites TRT throw-down challenge, minting new fastest known male and female ascents of Mount Washington. Find them on Instagram @josephinefisher and @david.a.sinclair.92Check out the Craft Pure Trail running shoe: https://www.craftsports.us/products/mens-pure-trail-running-shoeUse code fromthebackcountry at infinitnutrition.us and hyperlitemountaingear.com for 15% off your entire orderpodcast Instagram: https://www.instagram.com/fromthebackcountry/

Today, I'm going to tell you about some important foods and nutrients that should be part of a healthy diet for people over 50. Dr. David Sinclair, an expert on longevity, has researched longevity genes called sirtuins. NAD can increase sirtuins! NAD is derived from niacin. It works inside your mitochondria, converting food to energy. As we age, our NAD decreases. Many people take supplements and get injections to boost NAD. Dr. Abram Hoffer wrote a book about the diseases caused by too little niacin and how many diseases can be cured with mega doses. He's one of the doctors who started the Orthomolecular Medicine Group, which used high doses of nutrients to create therapeutic dosages. The following foods can increase NAD and should be part of a healthy diet for people over 50: 1. Beef liver 2. Grass-fed red meat 3. Probiotic-rich foods—raw sauerkraut, yogurt 4. Parsley (celery or chamomile tea can also work) 5. Curcumin—turmeric 6. Quercetin—onions 7. Omega-3 fatty acids—wild-caught fatty fish, cod liver Sulforaphane, found in cruciferous vegetables, is also beneficial for healthy aging. Broccoli sprouts and radish sprouts are great to add to salads! Anthocyanins, found in blue and purple foods like blueberries, blackberries, and purple cabbage, are also good for anti-aging. Niacin: The Real Story BOOK LINK: https://www.amazon.com/Niacin-Story-W... A Plague of Corn BOOK LINK: https://www.amazon.com/Plague-Corn-So...

This week we uncover the secret to a longer, healthier life as we sit down with Dr Buck Joffrey, a former neurosurgery and otolaryngology resident turned cosmetic surgeon and serial entrepreneur. Buck's journey from the operating room to the forefront of longevity science was ignited by a personal health scare and fueled by the pioneering work of David Sinclair. Join us as Buck shares his transformative story, emphasizing the profound impact of lifestyle changes like diet, exercise, and sleep on extending our lifespans, and even hints at the tantalizing possibility of age reversal.Explore the groundbreaking science of epigenetics and its crucial role in the aging process. We dissect how chemical modifications such as DNA methylation can alter gene expression and affect our biological clocks. With insights from researchers like Steve Horvath, we delve into how epigenetic clocks can predict biological age and mortality risk. Discover the potential of reversing epigenetic age through lifestyle choices, proper nutrition, and medications like rapamycin. Buck also underscores the vital need to manage inflammation and metabolic syndrome to mitigate age-related diseases.This episode also delves into holistic health optimization, covering the interplay between nutrition, exercise, and sleep. We discuss the alarming decline in testosterone levels in men and its implications for metabolic health and longevity. The conversation navigates the delicate balance between optimizing for longevity versus performance, shedding light on the Goldilocks effect of exercise. To top it off, we emphasize the importance of educating the public on these critical insights, ensuring that more people have access to life-extending knowledge.https://www.sapiopodcast.com/These sponsors support this podcast: Siphox Health, at-home health testing for all (15% off with this link):https://pathlongevity.com/Prolon, maker of the Fasting Mimicking Diet (20% off with this link):https://prolonlife.com/Lufkin Download a free sample chapter of Lies I Taught In Medical School here:https://www.robertlufkinmd.com/lies/ *** CONNECT WITH DR ROB ON SOCIAL MEDIA ***Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmdInstagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/Facebook: https://www.facebook.com/robertlufkinmd Threads: https://www.threads.net/@robertlufkinmd...

In this episode of Longevity by Design, our host Dr. Gil Blander speaks with Dr. David Sinclair, a professor of genetics at Harvard Medical School, about the science behind aging and how we can extend both lifespan and healthspan. Dr. Sinclair shares his groundbreaking research on the role of epigenetic changes in aging and the potential to reverse this process.He explains how lifestyle factors, such as diet and exercise, can greatly impact our longevity, and highlights the importance of regularly monitoring health markers like blood glucose and cholesterol. Dr. Sinclair emphasizes the power of technology, including blood tests and personalized health tracking, to help individuals live healthier, longer lives.The conversation also dives into cutting-edge research on longevity drugs and therapies, including gene therapy and reprogramming cells to a younger state. Dr. Sinclair discusses the promising future of treatments aimed at reversing aging and improving the quality of life well into old age.Episode highlights:Introduction: 00:00:00Why have you decided to be a scientist and not a painter: 00:02:40What is the difference between healthspan and lifespan: 00:06:00Can we extend our lifespan: 00:07:10What should you do to increase your healthspan: 00:09:40How can we increase our lifespan: 00:14:45Upcoming Season of David's Podcast: 00:19:40GLP-1 as a longevity drug: 00:21:40The information theory of aging: 00:25:40How are cells and organisms reprogrammed in the lab: 00:30:10What are the future opportunities in cell reprogramming: 00:32:50What is the effect of reprogramming on cancer cells: 00:36:00What is the effect of reprogramming on senescent cells: 00:38:50David's top tip for healthspan: 00:42:10Epigenetic Changes Drive the Aging ProcessDavid Sinclair explains that aging is not just wear and tear on the body, but a loss of information within cells. This concept, known as epigenetic aging, involves cells losing their ability to read the right genes at the right time. As cells age, they lose their identity, leading to aging and age-related diseases. The exciting part of this discovery is that these changes may be reversible. Dr. Sinclair's research focuses on reprogramming cells to restore their youthful function, potentially turning back the biological clock and extending healthspan and lifespan.Lifestyle Choices Are Key to LongevityDavid Sinclair emphasizes that simple lifestyle choices—like diet, exercise, and regular health monitoring—can have a profound impact on both healthspan and lifespan. He stresses the importance of moving regularly, avoiding processed foods, and maintaining a healthy weight. These actions, along with monitoring key biomarkers such as glucose and cholesterol, are crucial in delaying the onset of age-related diseases. Sinclair's father, who at 85 is in excellent health, serves as a prime example of how these practices can help people live healthier, longer lives.Reversing Aging with Genetic ReprogrammingOne of the most exciting advances in aging research is the potential to reverse aging at the cellular level through genetic reprogramming. Dr. Sinclair discusses his work using a combination of three genes—known as OSK—that can restore cells to a more youthful state. This breakthrough technology has already shown success in animals and is now being tested in humans. The hope is that genetic reprogramming could be used to treat age-related diseases, such as blindness, by resetting the clock on damaged cells, potentially revolutionizing the way we treat aging and extending human healthspan.  We Appreciate You!As a token of our gratitude, we're excited to offer you 15% off your next purchase. Simply click the link below to redeem your d

Today I sit down with fellow Las Vegan Sales Leader Justin Freishtat to discuss his entrepreneurial journey, which began with door-to-door direct sales, plus three subjects we are both very passionate about - health, nutrition and biohacking - and Justin shares his eating, workout and biohacking routine. 01:12:52   Show Notes: 01:30 - Eric welcomes entrepreneur Justin Freishtat to The Excellence Project and they discuss why they love living in Las Vegas. 08:58 - Justin shares that while playing hockey in college he sustained a serious injury. 11:47 - While still in college Justin starts in direct sales by selling organic food door-to-door. 16:00 - Justin reveals that after becoming very successful in direct sales in his 20's he bought a boat and lived on it.  22:07 - Justin recounts some crazy things that happened when he was selling door-to-door. 26:25 - Justin divulges one of the biggest secrets of his success. 28:03 - Justin leaves direct sales and realizes he needs to reinvent himself. 31:18 - Justin's health journey started with changing his eating habits. 40:45 - Justin details his exercise routine, which does not include cardio. 44:51 - Justin believes testing is the key to successful biohacking and also follows various biohacking protocols. 57:35 - Justin explains what an “intrapreneur” is and why it's the most comfortable position for him. 58:50 - Justin pulls back the curtain on forced innovation and how it has worked in his favor. 01:11:40 - Justin shares why choosing the right business vehicle is so important and explains how to choose the right one.   Resources From This Podcast:  Dr. Rewire https://drrewire.com/ Dave Shettler Texas??? Gary Brecka https://www.garybrecka.com/ Peter Attia https://peterattiamd.com/ Andrew Huberman https://www.hubermanlab.com/ David Sinclair https://sinclair.hms.harvard.edu/people/david-sinclair Joe Dispenza https://drjoedispenza.com/ 8 Sleep https://www.eightsleep.com/   Your Next Steps:   Purchase tickets for Go Pro Xperience 2024: https://nmpro.link/gpx24-pc   Get more likes and comments with engaging, unique posts written by AI in one click & access the AI version of the #1 Network Marketing expert, Eric Worre: https://nmpro.link/nmproai-pc   Visit Go Pro Academy for the best online Network Marketing courses: goproacademy.com/gpa2024   Go Pro: 7 Steps to Becoming a Network Marketing Professional - Purchase Eric's Book: https://nmpro.link/goprobook-pc   Hire Eric, the #1 Network Marketing Expert, to inspire and train your team! https://nmpro.link/hireeric-pc   For the latest (Free!) Network Marketing tips, tactics and strategies visit: https://nmpro.link/yt-subscribe   Questions or Comments?  Do you have questions you would like me to answer in future podcasts or comments on the show you'd like to share?  Email me at podcast@networkmarketingpro.com

What if you could turn back the clock—not just in terms of looking younger, but by actually reversing your biological age? Imagine a world where diseases like Alzheimer's or heart disease could be prevented, vision restored, and muscles rejuvenated, all by tapping into the hidden power of your DNA. This isn't a sci-fi dream, but a possibility being explored right now through epigenetics, a field of research that controls how your genes are expressed over time. Leading scientists, like Dr. David Sinclair from Harvard, believe that by reprogramming the way our genes behave, we could one day reverse aging and live longer, healthier lives. In today's podcast, Dr. Bray will dive into the exciting breakthroughs that are bringing age reversal closer to reality. From the Nobel Prize-winning discovery that turned back time in cells, to Sinclair's revolutionary work restoring vision in aging mice, the science of epigenetic reprogramming is poised to transform our understanding of aging. But while we wait for full-body rejuvenation therapies, there are already practical steps you can take to slow down your biological clock today. Listen in to find out how the future of aging might be under your control sooner than you think. QUOTES BY DR. BRAY  “Our genes are like a script; epigenetics is the director.” “Simple lifestyle changes can make a HUGE difference.” “High stress causes issues to your body and your brain; don't stress out so much!!” “Take naps!”

Episode 48: Today we are diving into the science of skincare and aging with Dr. Kyle Landry, President of Delavie Skincare. Dr. Kyle shares his journey from food scientist to postdoctoral researcher, working alongside renowned anti-aging expert Dr. David Sinclair. Together, they discovered groundbreaking ingredients like Bacillus Lysate that combat skin aging at the cellular level.Dr. Kyle uncovers how your diet, gut health, and even the bacteria in your mouth impacts your skin. He also explores the compounding negative effects of chronic, low-dose exposure to toxins and pollution, showing how everyday environmental factors accelerate aging. Dr. Kyle shares the red flags to watch out for when choosing products, explaining why many skincare claims don't hold up to scientific scrutiny. Plus, we get his expert advice on proper product application, the impact of stress and sleep on skin health, and what small, science-backed changes you can make to lay the foundation for lasting, healthy, youthful skin. He even leaves us with thoughts on red light therapy masks, what to know when it comes to skincare labels, and why he believes a simplified, efficient skincare routine is the key to slowing the aging process!USE CODE “GRACIE” FOR 25% OFF Delavie Skincare: https://www.delaviesciences.com/Keep up with Dr. Kyle & Delavie by following his accounts below:Dr. Kyle Landry https://www.instagram.com/kylelandryphd/Delavie Skincare https://www.instagram.com/delaviesciences/?hl=enCONNECT WITH ME:Follow Wellness Her Way on Instagram for podcast updates: HERE Connect with me on TikTok: HEREConnect with me on Instagram: HERESee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Send us a textMichelino Sunseri, the North Face athlete who just shattered the Fastest Known Time (FKT) on the Grand Teton, joins us for a thrilling episode. Discover the journey of this extraordinary runner, from his early days setting records at the RUT to his life-changing victories at races like Broken Arrow 46k and SpeedGoat 50K. Michelino opens up about his Italian roots, growing up, and his post-pandemic move to Driggs, Idaho. His unwavering spirit and infectious passion for the mountains will leave you inspired to pursue your own outdoor adventures.We also take a lighthearted yet profound look at the world of trail running, unraveling Michelino's transition from mountain trails to the concrete jungles of college life. Listen to amusing stories like running home from bars after losing a driver's license and the influence of an unconventional high school coach who emphasized trail running. Michelino shares his journey through ultra-marathons, the mentorship of Peter Fane, and his exhilarating races against elite competitors like Hayden Hawks and David Sinclair. The chapter reveals the mental fortitude and competitive spirit that drive Michelino's success in mountain running.On top of epic running tales, we explore technical skiing and outdoor gear innovations, highlighting the creative genius of Kyle Siegel's belt design. This episode also delves into wildlife encounters, from grizzly bear run-ins to the rich fauna of Wyoming. Finally, we venture into cosmic debates about aliens, living in a simulation, and the Mandela Effect. Don't miss our preview of the elite athlete press conference and live race commentary at Pike's Peak Week. This episode is an adventure-packed blend of inspiration, humor, and a deep appreciation for the great outdoors.

Dr. David Sinclair is a leading world authority on aging and longevity. He is Professor of Genetics at Harvard Medical School. David is the author of Lifespan: Why We Age - and Why We Don't Have To & the host of Lifespan podcast. Show sponsor: LMNT - Claim your free LMNT Sample Pack with any purchase by using this link Show notes: https://ultimatehealthpodcast.com/617

Prepare to dive into the groundbreaking realm of reversing aging! In this electrifying mashup episode, I'm joined by visionary scientists David Sinclair and Sergey Young, as we unravel the secrets behind scientific advancements that promise to turn back our biological clocks. This isn't just science fiction—it's the dawn of a new era in longevity research. We'll explore cutting-edge discoveries like the Horvath clock, a revolutionary method that predicts biological aging more accurately than ever before. Here's what you'll discover: - The Importance of Biological Markers: David Sinclair sheds light on how we might not just slow down aging but potentially reverse it, using interventions that modify our biological markers. - Understanding Biological Aging: Learn the mechanisms that signal our biological age and the pioneering techniques to manipulate these markers. - The Power of Caloric Restriction: Sergey Young breaks down why reducing caloric intake isn't just about losing weight—it's about gaining years of healthy life. - Future of Longevity: We'll discuss the potential of emerging technologies and lifestyle changes that could extend our healthy lifespan by decades. This episode is a must-listen for anyone fascinated by the potential to enhance their healthspan and challenge the traditional boundaries of aging. Join us as we decode the science that could redefine old age, offering a future where living healthily into our 100s might just be the norm. Tune in to transform your understanding of aging and learn how to embrace the promising future of longevity! Learn more about your ad choices. Visit podcastchoices.com/adchoices

Send us a textAbout the guest: Austin Argentieri, PhD is a researcher in the Analytic & Translational Genetics Unit at the Massachusetts General Hospital with academic appointments at Harvard & the Broad Institute. His research focuses on large-scale analyses to to understand human aging.Episode summary: Nick and Dr. Argentieri discuss: chronological vs. biological age; DNA methylation and aging clocks; proteomics and protein measurements in aging research; health, longevity, and human healthspan; and more.Related episodes:Aging, mTOR, Sirtuins, Rapamycin, Metformin, the Truth of Resveratrol & Longevity Supplements, David Sinclair & Anti-Aging Myths | Matt Kaeberlein | #151Cellular Aging, Taurine, Nutrition, Senescence, Longevity, Mitochondria, Metabolism | Vijay Yadav | #122*This content is never meant to serve as medical advice.Support the Show.All episodes (audio & video), show notes, transcripts, and more at the M&M Substack Try Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase.Try SiPhox Health—Affordable, at-home bloodwork w/ a comprehensive set of key health marker. Use code TRIKOMES for a 10% discount.Try the Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off.Learn all the ways you can support my efforts

David Sinclair is a professional trail runner and ski mountaineer living in Vermont. Though he flies under the radar, David is as talented and capable of a mountain runner as anyone in the USA. This summer he's registered two very impressive victories at the Broken Arrow 46k and the Speedgoat 50k, in addition to an FKT on Mt. Shasta.    Follow David Sinclair on Strava   REGISTER FOR THE BIG ALTA   Sponsors: Join our Nutrition Club with The Feed and get $80 to spend on nutrition Use code freetrail10 for 10% off Speedland Footwear Grab a trail running pack from Osprey Use code FT15 for 15% off Gnarly Nutrition Go to ketone.com/freetrail30 for 30% off a subscription of Ketone IQ Freetrail Links: Website | Freetrail Pro | Patreon | Instagram | YouTube | Freetrail Experts   Dylan Links: Instagram | Twitter | LinkedIn | Strava   ________________________   Other Freetrail podcast episodes you might enjoy: Courtney Dauwalter | Hardrock 100 Post-Race Interview Jasmin Paris | Barkley Marathon Finisher Jim Walmsley | UTMB Post-Race Interview Also, please check out our other podcast, Second Nature: https://podcasts.apple.com/us/podcast/second-nature/id1737242598

The Harvard geneticist sold a fake miracle pill to GlaxoSmithKline for $720,000,000, and now wants the world to believe that he has discovered a new immortality molecule. Everyone wants to live a long and healthy life. No one wants to die. The oldest scam in history is the longevity lie. The first writing recorded on Sumerian clay tablets recounts the story of Gilgamesh's failed quest to bring his friend back from the dead. The immutable fact of mortality has dogged human kind since its very beginning. And yet every age has brought with it its own crop of magicians, alchemists and scientists promising eternal life. Their pitch is always the same: everyone who came before them was a charlatan, but they have the secret sauce. The most famous longevity grifter of our age is no different. If you've ever heard a news story that a glass of red wine might make you live longer, it was because of his groundbreaking research. Harvard geneticist David Sinclair is one of the most decorated scientists on the planet. He's listed as an author on more than 500 papers, his work has been cited more than 96,000 times and he holds 50 patents. He was the editor of the journal Aging. Resume aside, David Sinclair is no different than any other health grifter throughout the ages, and great fortunes have been squandered in pursuit of his “science.” In this week's video I dive into his 25 year history of scientific mistakes, lies and fraud. I show how he used disproven research on the chemical “resveratrol” to sell a best selling book and, ultimately, a company to the pharmaceutical drug maker GlaxoSmithKlein for $720,000,000. Two years after the sale, the research was proven to not work, and Sinclair became one of the richest scientists in America. Now, ten years after that work fell apart, Sinclair is at it again selling the idea of a new immortality molecule called NMN. This video took me three weeks to put together, but it was worth the wait.

About the Guest(s): Serena Poon is an acclaimed wellness and longevity nutritional practitioner based out of Los Angeles. With an extensive travel itinerary that takes her across the globe, Serena works tirelessly to help her clients achieve optimal health. After completing a degree at UC Berkeley, her father's cancer diagnosis pivoted her career trajectory from pre-law to nutrition and holistic health. Serena's unique method, “Culinary Alchemy,” integrates food, energy work, and mindfulness practices to promote holistic healing. She has furthered her expertise by becoming a Reiki master and partnering with world-renowned longevity experts at Harvard Medical School. Episode Summary: In this captivating episode of the Laser Light Show, Doctors Chad Woolner and Andrew Wells sit down with wellness expert Serena Poon to delve into her extraordinary journey and the holistic practices she uses to optimize health and longevity. From a promising pre-law student to a highly sought-after nutritional practitioner, Serena shares her transformative path marked by personal tragedy and professional triumphs. Throughout the episode, Serena discusses the critical role of holistic health practices, including low-level laser therapy, in enhancing patients' wellbeing. Her story underscores the importance of integrating various healing modalities like nutrition, energy work, and light therapy. Serena also touches on the future of healthcare, emphasizing the profound impact advanced technologies like AI and biotech will have on healthspan and longevity. Her philosophy champions the synchronization of Eastern and Western medical practices to provide patients with a more comprehensive and individualized healthcare approach. Key Takeaways: Holistic Healing Approach: Serena's method, "Culinary Alchemy," combines nutrition with energy work and mindfulness to enhance overall health and healing. Managing Health During Travel: Serena shares practical tips and rituals for maintaining health while managing an extensive travel schedule. Importance of Healthspan: Extending not just lifespan but the quality and vibrancy of life years through holistic practices and cutting-edge health technologies. Combining Eastern and Western Medicine: Advocacy for an integrated healthcare approach that leverages the strengths of both conventional and alternative practices. Future of Healthcare: Optimistic outlook on how AI and biotech innovations can revolutionize health preservation and disease management. Notable Quotes: “Home is an amazing place, that's your sanctuary, but I think the best part is just wherever you are, it's your home.” “Getting older doesn't mean getting sick. Getting older doesn't necessarily mean frailty.” “The answer isn't that there is no answer. It's just that we haven't figured out what that answer is yet.” "I really believe in quantum physics, quantum, light, waves, and frequencies, and there's so many different ways to capture that." "We really have to shift our perception of what living longer means ... it's not being miserable and suffering." Resources: Serena Poon's Official Website Dr. David Sinclair's Research and Publications Tune in to this enlightening episode to uncover more about Serena Poon's innovative holistic health strategies and discover how integrating various healing modalities can significantly impact your quality of life. Stay inspired and uplifted by following the Laser Light Show for more groundbreaking insights on enhancing your health and wellbeing.

Former House Speaker Newt Gingrich, author of March to the Majority and host of Newt's World, joins Jamie to debate foreign policy, Donald Trump, the media, and coup d'états. The Agenda: —The preservation of Israel —Going all in on Ukraine —What Never Trumpers miss about Donald Trump —Who is the “establishment” and who is not? —The assassination attempt —How will history remember January 6 —The left-wing drift of the media —Was Joe Biden forced out by a coup? —Technological and biological advances Show Notes: —Letters of Jonathan Netanyahu —A trio of books on real age: Michael F. Roizen's The Great Age Reboot, Nir Barzilai's Age Later, and David Sinclair's Lifespan —Peter Drucker's The Effective Executive —Arnold Toynbee's A Study of History The Dispatch Podcast is a production of The Dispatch, a digital media company covering politics, policy, and culture from a non-partisan, conservative perspective. To access all of The Dispatch's offerings—including members-only newsletters, bonus podcast episodes, and weekly livestreams—click here. Learn more about your ad choices. Visit megaphone.fm/adchoices

Have you listened to the FULL EPISODE yet?"We can actually grow little brains in the dish too... And we can age them forwards, make them older... And then we reverse it." - Dr. David SinclairPrepare for a journey into the cutting edge of longevity science as Lewis sits down with world-renowned geneticist and aging expert, Dr. David Sinclair. In this electrifying episode, Sinclair unveils the revolutionary concept that aging isn't just a natural process - it's a disease we can potentially cure. From the secrets of 'longevity genes' to the mind-bending ability to grow and reverse-age human brain cells in a lab, Sinclair's insights will challenge everything you thought you knew about getting older.But this isn't just about extending life - it's about reimagining what it means to be human. Sinclair dives deep into the ethical implications and practical possibilities of his work, offering a tantalizing glimpse into a future where age-related diseases could become a thing of the past. Whether you're a science enthusiast or simply someone who wants to live their best life for as long as possible, this episode is a must-listen. Tune in now and discover how the fountain of youth might just be hiding in your own DNA!Sign up for the Greatness newsletter!

Have you listened to the FULL EPISODE yet?"The way to think of this is, if you've ever heard of the epigenome, these are the control systems that control our DNA. It turns out that that system you can measure. It's chemicals on your DNA that change over time predictably. And we've just developed a way to measure that 100 times cheaper than it was before. And I'm gonna bring this test to the public so that people can test their biological age." - Dr. David SinclairIn this fascinating episode, renowned longevity expert Dr. David Sinclair reveals groundbreaking insights into the science of aging and how our lifestyle choices directly impact our biological age. Dr. Sinclair introduces the concept of biological age versus chronological age, explaining how advanced testing methods can now determine how quickly or slowly our bodies are aging at a cellular level.Dr. Sinclair shares his personal experience with optimizing his own health, discussing how he's managed to maintain a biological age significantly younger than his chronological age. He details the development of new, more accessible testing methods, including a cheek swab DNA methylation test, that could revolutionize how we monitor and manage our health. Throughout the conversation, Dr. Sinclair emphasizes the importance of understanding the impact of our daily habits - from smoking and alcohol consumption to exercise and diet - on our biological age. His insights offer listeners a roadmap to potentially slow down or even reverse their aging process, providing hope and practical strategies for those seeking to extend their healthspan and lifespan.Sign up for the Greatness newsletter!

A Note from James:I particularly want to reverse my aging. I'm not concerned about being able to run a mile or anything like that; I just want to reverse the aging of my brain. I feel there's a definite difference between my brain now and when I was younger. By the way, culturally, we acknowledge that the brain ages. Not only medically, but culturally, you have to adapt to being the wise older person rather than the sharp young person.We had a great conversation with Arthur Brooks about this. He wrote an excellent book, which I can't recommend enough, called "From Strength to Strength." That podcast with Arthur Brooks changed my life in how I view my brain aging. Additionally, several podcasts with David Sinclair about the aging process have also been life-changing.I have used the supplements he recommended and made the lifestyle changes he suggested back in 2019. David has conducted a lot of research in the five years since his book "Lifespan" was released, and I wanted to see what the current state of his research was. So, he came on the podcast.I'm very grateful; he doesn't do many podcasts. He shared some incredible discoveries and new information, giving me real insight. We discussed everything related to what he's doing in anti-aging and what he's discovered since the last time I had him on. At the special request of our listeners, I also asked him about testosterone.Towards the end of the podcast, I asked him about that, and his answer was very interesting. Here's David.Episode Description:Today, James discusses personal motivations for wanting to reverse aging, specifically targeting brain aging. The conversation moves into the broader cultural and scientific understandings of aging, touching on insights from Arthur Brooks and David Sinclair's research. Sinclair's work on anti-aging, including lifestyle changes and supplement use recommended by him, is highlighted, mentioning his book 'Lifespan' and the progress in his research over the past five years. Key discussions include the information theory of aging, the role of DNA and epigenetics in aging, and the concept of age reversal through maintaining or restoring the epigenome's integrity. The episode covers the potential of using Yamanaka factors for age reversal, the challenges in translating these findings from mice to humans, and regulatory considerations for human trials. Sinclair also touches on his ongoing work in developing chemical cocktails for age reversal, comparing lifestyle changes to these scientific advances.  Episode Summary:00:00 The Quest for Age Reversal: Personal Motivations and Influential Conversations01:11 Diving Deep into David Sinclair's Research on Anti-Aging02:24 Exploring the Information Theory of Aging and DNA's Role04:30 The Potential of Epigenetics in Reversing Aging07:14 The Challenges and Ethics of Age Reversal Technologies09:01 The Future of Anti-Aging: From Gene Therapy to Accessible Pills10:53 Debunking Myths and Addressing Controversies in Anti-Aging Supplements15:13 The Cutting-Edge of Aging Research: Yamanaka Factors and Epigenetic Reset25:05 The Philosophical and Practical Implications of Rejuvenation Research27:57 Unveiling New Breakthroughs in Cellular Biology28:19 Decoding the Mystery of Emanarcha Factors29:18 Exploring the Potential of Yamanaka Factors in Age Reversal29:43 The Future of Age Reversal: From Theory to Practice30:52 Innovative Approaches to Rejuvenation and Safety Measures31:52 Understanding the Complexity of Aging Across Different Organs34:57 The Fascinating World of Epigenetic Aging and Brain Plasticity37:20 Pushing the Boundaries: Chemical Cocktails for Rejuvenation39:46 Comparing Lifestyle Factors and Chemical Interventions in Aging40:56 Exploring the Possibilities of Reversing Menopause in Mice45:09 Navigating the Path to Human Trials and Regulatory Approval49:18 The Potential and Ethics of Off-Label Uses for...

A Note from James:I particularly want to reverse my aging. I'm not concerned about being able to run a mile or anything like that; I just want to reverse the aging of my brain. I feel there's a definite difference between my brain now and when I was younger. By the way, culturally, we acknowledge that the brain ages. Not only medically, but culturally, you have to adapt to being the wise older person rather than the sharp young person.We had a great conversation with Arthur Brooks about this. He wrote an excellent book, which I can't recommend enough, called "From Strength to Strength." That podcast with Arthur Brooks changed my life in how I view my brain aging. Additionally, several podcasts with David Sinclair about the aging process have also been life-changing.I have used the supplements he recommended and made the lifestyle changes he suggested back in 2019. David has conducted a lot of research in the five years since his book "Lifespan" was released, and I wanted to see what the current state of his research was. So, he came on the podcast.I'm very grateful; he doesn't do many podcasts. He shared some incredible discoveries and new information, giving me real insight. We discussed everything related to what he's doing in anti-aging and what he's discovered since the last time I had him on. At the special request of our listeners, I also asked him about testosterone.Towards the end of the podcast, I asked him about that, and his answer was very interesting. Here's David.Episode Description:Today, James discusses personal motivations for wanting to reverse aging, specifically targeting brain aging. The conversation moves into the broader cultural and scientific understandings of aging, touching on insights from Arthur Brooks and David Sinclair's research. Sinclair's work on anti-aging, including lifestyle changes and supplement use recommended by him, is highlighted, mentioning his book 'Lifespan' and the progress in his research over the past five years. Key discussions include the information theory of aging, the role of DNA and epigenetics in aging, and the concept of age reversal through maintaining or restoring the epigenome's integrity. The episode covers the potential of using Yamanaka factors for age reversal, the challenges in translating these findings from mice to humans, and regulatory considerations for human trials. Sinclair also touches on his ongoing work in developing chemical cocktails for age reversal, comparing lifestyle changes to these scientific advances.  Episode Summary:00:00 The Quest for Age Reversal: Personal Motivations and Influential Conversations01:11 Diving Deep into David Sinclair's Research on Anti-Aging02:24 Exploring the Information Theory of Aging and DNA's Role04:30 The Potential of Epigenetics in Reversing Aging07:14 The Challenges and Ethics of Age Reversal Technologies09:01 The Future of Anti-Aging: From Gene Therapy to Accessible Pills10:53 Debunking Myths and Addressing Controversies in Anti-Aging Supplements15:13 The Cutting-Edge of Aging Research: Yamanaka Factors and Epigenetic Reset25:05 The Philosophical and Practical Implications of Rejuvenation Research27:57 Unveiling New Breakthroughs in Cellular Biology28:19 Decoding the Mystery of Emanarcha Factors29:18 Exploring the Potential of Yamanaka Factors in Age Reversal29:43 The Future of Age Reversal: From Theory to Practice30:52 Innovative Approaches to Rejuvenation and Safety Measures31:52 Understanding the Complexity of Aging Across Different Organs34:57 The Fascinating World of Epigenetic Aging and Brain Plasticity37:20 Pushing the Boundaries: Chemical Cocktails for Rejuvenation39:46 Comparing Lifestyle Factors and Chemical Interventions in Aging40:56 Exploring the Possibilities of Reversing Menopause in Mice45:09 Navigating the Path to Human Trials and Regulatory Approval49:18 The Potential and Ethics of Off-Label Uses for Gene Therapy53:53 Personal Insights and Experiments in Anti-Aging ------------What do YOU think of the show? Head to JamesAltucherShow.com/listeners and fill out a short survey that will help us better tailor the podcast to our audience!Are you interested in getting direct answers from James about your question on a podcast? Go to JamesAltucherShow.com/AskAltucher and send in your questions to be answered on the air!------------Visit Notepd.com to read our idea lists & sign up to create your own!My new book, Skip the Line, is out! Make sure you get a copy wherever books are sold!Join the You Should Run for President 2.0 Facebook Group, where we discuss why you should run for President.I write about all my podcasts! Check out the full post and learn what I learned at jamesaltuchershow.com------------Thank you so much for listening! If you like this episode, please rate, review, and subscribe to “The James Altucher Show” wherever you get your podcasts: Apple PodcastsiHeart RadioSpotifyFollow me on social media:YouTubeTwitterFacebookLinkedIn

“We have to spend time on our health rather than spend time on diseases," says Nir Barzilai, M.D. Nir, a renowned longevity researcher, joins us to discuss pharmaceutical interventions to delay aging, plus: - What are gerotherapeutics? (~00:19) - What you need to know about antagonistic nutrients (~04:25) - Why healthcare costs don't have to increase as people live longer (~08:55) - SuperAgers vs. Blue Zones (~12:40) - What are some science-backed longevity genes? (~15:14) - The hallmarks of aging (~19:54) - How metformin extends longevity (~22:46) - Who is the right candidate for longevity drugs? (~25:03) - The best age to take a longevity drug (~31:55) - Lifestyle interventions for healthy aging (~34:17) - Is fasting actually necessary? (~38:18) - What to know about mTOR (~41:19) - How to test your biological age (~43:10) - What to do in your 20s and 30s for healthy aging (~48:16) - The role of mindset in aging (~53:45) - How repurposing drugs has saved lives (~57:45) - Why women have the aging advantage (~01:03:42) Take 25% off vitamin D3 potency+ with code D3POD. Cannot combine with gift cards or other discount codes. Apply code at checkout. Referenced in the episode: - Nir's book, Age Later - Nir's SuperAger study - The SuperAgers family study - Learn about the antagonistic pleiotropy hypothesis of aging - Nir's study on metformin & aging - TAME trial - A study on metformin & COVID outcomes - A study on metformin & muscle hypertrophy - Nir's study on organ aging - A study on metformin & IGF1 - A study on centenarians & IGF1 - Episodes #363, #217 & #170, with David Sinclair, Ph.D. - Episode #207, with David Fajgenbaum, M.D., MBA, M.Sc., FCPP We hope you enjoy this episode, and feel free to watch the full video on YouTube! Whether it's an article or podcast, we want to know what we can do to help here at mindbodygreen. Let us know at: podcast@mindbodygreen.com. Learn more about your ad choices. Visit megaphone.fm/adchoices

What makes a food – a comfort food? Are you actually comforted by these foods? This episode begins by revealing why people crave certain comfort foods and what eating those foods does for you. https://www.theatlantic.com/health/archive/2015/04/why-comfort-food-comforts/389613/  Is it really possible to slow down the aging process and increase how long you live? There are a lot of products offered that supposedly do that. And while some of it may be hype, there is a lot of serious research into how to increase lifespan by slowing the process of aging. One of the people on the cutting edge of this research is Dr. David Sinclair. He is a leading longevity expert, professor at Harvard University and author of the book Lifespan: Why we Age and Why We Don't Have To (https://amzn.to/3KXpzN8). Listen to our conversation as he explores proven ways to turn back the clock and add years to your life. A day is 24 hours long. Humans have 5 senses. It is lack of gravity that allows astronauts on the International Space Station to float in the air. These are a few examples of things most people believe to be true that are not. Or, they may have a little truth to them but not as much as you think. That is what Philip Bouchard is here to discuss. He is a software engineer, educator and author of the book The Stickler's Guide to Science in the Age of Misinformation: The Real Science Behind Hacky Headlines, Crappy Clickbait, and Suspect Sources (https://amzn.to/3tH5swJ).  Your stomach growls when you are hungry. But hunger is not the reason it growls. In fact, it isn't even your stomach that is growling. Listen as I explore what is really going on to make all that noise at exactly the wrong time. https://www.medicalnewstoday.com/articles/319901 PLEASE SUPPORT OUR SPONSORS! Indeed is offering SYSK listeners a $75 Sponsored Job Credit to get your jobs more visibility at https://Indeed.com/SOMETHING We love the Think Fast, Talk Smart podcast! https://www.gsb.stanford.edu/business-podcasts/think-fast-talk-smart-podcast Go to https://uscellular.com/TryUS and download the USCellular TryUS app to get 30 days of FREE service! Keep you current phone, carrier & number while testing a new network! NerdWallet lets you compare top travel credit cards side-by-side to maximize your spending! Compare & find smarter credit cards, savings accounts, & more https://NerdWallet.com TurboTax Experts make all your moves count — filing with 100% accuracy and getting your max refund, guaranteed! See guarantee details at https://TurboTax.com/Guarantees Dell TechFest starts now! To thank you for 40 unforgettable years, Dell Technologies is celebrating with anniversary savings on their most popular tech. Shop at https://Dell.com/deals Learn more about your ad choices. Visit podcastchoices.com/adchoices

Is aging a disease that can be cured? Neil deGrasse Tyson and cohosts Chuck Nice and Gary O'Reilly discover the field of epigenetics, the Information Theory of Aging, and curing blindness for mice with Professor of Genetics at Harvard Medical School, David Sinclair.NOTE: StarTalk+ Patrons can listen to this entire episode commercial-free here: https://startalkmedia.com/show/is-aging-a-disease-epigenetics-with-david-sinclair/Thanks to our Patrons Jason L, Daniel Holzmann, Anne P Vance, Unknown, Myles G Blanton, Paul A. Straus, and Gregory Dees for supporting us this week.

Dr. Susanna Søberg is a leading expert in the world of cold and heat exposure therapy. With years of dedicated research, she has become a trailblazer in understanding the profound effects of deliberate temperature exposure on the human body and mind. Her groundbreaking findings and contributions to the field have positioned her as a visionary in the realm of metabolism, psychology, and holistic well-being. Dr. Søberg's expertise is not only shaping our understanding of cold and heat therapy but also empowering individuals to optimize their physical and mental health through these transformative practices.Learn more about Dr. Søberg's research and programs at soeberginstitute.comIn this episode you will learnHow Dr. Susanna Søberg's groundbreaking research is changing the way we view cold and heat therapy.The key findings in her research that can revolutionize your metabolism.The distinction between white fat and brown fat, and how cold therapy affects both.The profound psychological effects of cold therapy on your mood and mental well-being.The optimal frequency, duration, and benefits of cold plunges and saunas for your health.For more information go to www.lewishowes.com/1558For more Greatness text PODCAST to +1 (614) 350-3960More SOG episodes we think you'll love:Wim Hof – https://link.chtbl.com/1043-guestDr. David Sinclair – https://link.chtbl.com/1232-pod

Sleep is powerful. You've probably heard this statement a thousand times. It's all over the books, media, podcasts, videos, everywhere. But many of us still lack a deep understanding of its power and how to use it for our benefit. In today's episode, 3 guests dive deeper into understanding the amazing human mind and how sleep is critical to operating at 100% mental capacity. We talk about how to unlock its power — particularly during really hectic seasons of life.Andrew Huberman is a neuroscientist at Stanford University. He also runs the Huberman Lab, which studies how the brain functions, how it changes through experiences, and how to repair the brain after injury or disease. David Sinclair is a tenured Professor in the Department of Genetics at the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School and serves as President of the Academy for Health and Lifespan Research. He is best known for his work on understanding why we age and how to slow its effects.Dr. Matthew Walker earned his degree in neuroscience from Nottingham University, UK, and his Ph.D. in neurophysiology from the Medical Research Council in London. Dr. Walker researches the impact of sleep on human health and disease, and he's written the international bestseller, Why We Sleep, unlocking the power of sleep and dreams.In this episode you will learnHow inadequate sleep impacts brain function and overall mental health.The ideal amount of sleep necessary for optimal health and well-being.The effects of a poor diet on sleep quality, even when you're getting sufficient sleep, compared to the impact of a good diet on nights of poor sleep.Ways to influence and potentially control the nature of your dreams.Techniques to train your brain for more frequent lucid dreaming experiences.For more information go to www.lewishowes.com/1545For more Greatness text PODCAST to +1 (614) 350-3960Listen to the full episodes here:Andrew Huberman – https://link.chtbl.com/1219-podDavid Sinclair – https://link.chtbl.com/1004-guestMatthew Walker – https://link.chtbl.com/1476-pod