Podcasts about exposome

My guest is Dr. Mark Hyman, M.D., a physician and world leader in the field of functional medicine. We discuss a systems-based framework for diagnosing and treating the root causes of disease, rather than simply managing symptoms. We also cover cutting-edge health and longevity tools such as peptides, NAD/NMN, exosomes, proactive blood testing and cancer screening, as well as nutrition, supplementation, detoxification, and strategies for addressing specific diseases and health challenges. This discussion will benefit anyone seeking to improve their vitality or combat specific health concerns. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Joovv: https://joovv.com/huberman Eight Sleep: https://eightsleep.com/huberman Function: https://functionhealth.com/huberman ROKA: https://roka.com/huberman Timestamps 00:00:00 Dr. Mark Hyman 00:01:48 Functional Medicine, Chronic Fatigue Syndrome, Mercury; Systems Medicine 00:08:51 Metabolic Psychiatry; Medicine, Creating Health vs Treating Disease 00:12:19 Sponsors: Joovv & Eight Sleep 00:15:06 Wholistic View of Body, Root Causes 00:19:48 Medicine & Research; “Exposome”, Impediments & Ingredients for Health, Whole Foods 00:26:30 Seed Oils, Starch & Sugar, Ultra-Processed Foods; Obesity Rise 00:36:27 Sponsors: Function & ROKA 00:40:05 Tool: Ingredients for Health, Personalization; Multimodal Approach 00:46:25 Essential Supplements, Omega-3s, Vitamin D3, Multivitamin, Iodine, Methylated B12 00:56:54 Supplements & Traditional Medicine; Limited Budget & Nutrition 01:02:54 Air, Tool: Air Filters; Tap Water Filter; Tool: Health, Expense & Whole Foods 01:09:03 Food Industrialization, Processed Foods 01:14:23 Sponsor: AG1 01:16:18 Declining American Health & Nutrition, Politics, MAHA 01:26:03 Toxins, Food Additives, Generally Recognized As Safe (GRAS) 01:29:25 SNAP Program & Soda, Food Industry & Lobbying 01:36:58 Big Food, Company Consolidation, Nutrition Labels 01:44:21 GLP-1 Agonists, Doses, Risks; Food as Medicine, Ketogenic Diet 01:51:29 Cancer, Diets & Alcohol 01:54:03 Blood Markers, ApoB, Cholesterol, Tool: Test Don't Guess, Individualization 02:02:54 Mercury; Tool: Detoxification, Sulforaphane, N-Acetylcysteine (NAC) 02:04:56 Endocrine Disrupting Chemicals, Fertility, Tool: Hormone Panels; Heavy Metals 02:11:36 Upregulate Detox Pathways, Gut Cleanse, Tools: Cilantro Juice, Fiber 02:17:08 Peptides, PT-141 (Vyleesi), BPC-157, Thymosin Alpha-1; Risks, Cycling 02:22:03 Cancer Screening, Data & Personalized Health; Alzheimer's Disease 02:30:45 Longevity Switches, NAD, NMN; Exosomes, Stem Cells 02:39:50 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures

Send us a textDr. Alycia Halladay, Ph.D. is Chief Science Officer of the Autism Science Foundation ( https://autismsciencefoundation.org/teams/dr-alycia-halladay/ ), a nonprofit organization dedicated to supporting people with autism and their families by funding scientific research to understand the causes of autism and to develop better treatments, to enable individuals with autism to lead fulfilling lives with dignity.Dr. Halladay oversees the scientific activities, grants, and initiatives of ASF. She also produces a weekly podcast aimed specifically at explaining scientific information to the public. Prior to joining ASF in 2014, Dr. Halladay served as the Senior Director of Clinical and Environmental Sciences at Autism Speaks. Dr. Halladay has authored over two dozen peer reviewed papers in science journals. She also serves on the Board of Directors for the Phelan McDermid Syndrome Foundation and on the Interagency Autism Coordinating Committee.  Dr. Halladay received a Ph.D. in biopsychology from Rutgers in 2001 and completed a postdoctoral fellowship in pharmacology and toxicology at the University of Medicine and Dentistry of NJ in 2004 and is on the editorial board of Neurotoxicology and Frontiers in Pediatrics.  She still holds a faculty appointment at Rutgers. Important Episode Link - Autism BrainNet - https://www.autismbrainnet.org/ #AutismScienceFoundation #AlyciaHalladay #ChiefScienceOfficer #AutismSpectrumDisorder #Genetics #Epigenetics #Exposome #Neurotoxicology #Biopsychology #Pharmacology #Toxicology #ProgressPotentialAndPossibilities #IraPastor #Podcast #Podcaster #Podcasting #ViralPodcast #STEM #Innovation #Science #Technology #ResearchSupport the show

Could the air we breathe, the food we eat, or the chemicals in our everyday environment be accelerating our aging process? A recent study published in Aging suggests that exposure to certain environmental chemicals may be linked to faster biological aging through changes in DNA. These findings could have major implications for public health and longevity. Understanding How Scientists Measure Aging at the DNA Level Aging is not just about wrinkles and gray hair—it happens at the molecular level too. Scientists use epigenetic clocks to measure biological aging, which can differ from a person's actual chronological age. These clocks track DNA methylation, a type of chemical modification that can change over time due to environmental factors like diet, pollution, and chemical exposure. Until now, there has been little research into how widespread environmental chemicals impact these aging markers. The Study: Investigating the Impact of Environmental Pollutants on Aging A research team led by first author Dennis Khodasevich and corresponding author Andres Cardenas from Stanford University, conducted an exposome-wide association study to examine how different environmental pollutants affect epigenetic aging. Using data from the National Health and Nutrition Examination Survey (NHANES), they analyzed blood and urine samples from 2,346 adults aged 50 to 84. The study measured 64 environmental chemicals, including heavy metals, pesticides, plastics, and tobacco-related compounds, to identify potential links to accelerated aging. The study titled “Exposome-wide association study of environmental chemical exposures and epigenetic aging in the national health and nutrition examination survey,” was published in Aging on February 11, 2025. Full blog - https://aging-us.org/2025/03/how-environmental-chemicals-may-accelerate-biological-aging/ Paper DOI - https://doi.org/10.18632/aging.206201 Corresponding author - Andres Cardenas - andresca@stanford.edu Video short - https://www.youtube.com/watch?v=WcL-K399a7M Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206201 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, epigenetic aging, environmental exposures, exposome, epigenetics About Aging-US The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population. The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.) Please visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

80% of diseases are impacted by environment or lifestyle described as your exposome.  Thomas Hartung expects information from studying the exposome will bring benefits on par with those brought by studying the human genome.

This study explores how environmental exposures (exposome)

BUFFALO, NY — March 5, 2025 — A new #research paper was #published in Aging (Aging-US) on February 11, 2025, Volume 17, Issue 2, titled “Exposome-wide association study of environmental chemical exposures and epigenetic aging in the national health and nutrition examination survey.” First author Dennis Khodasevich and corresponding author Andres Cardenas from Stanford University, and colleagues from other U.S. institutions, studied how exposure to harmful chemicals in the environment affects aging. Using data from the National Health and Nutrition Examination Survey (NHANES), they discovered that cadmium, lead, and cotinine are linked to faster biological aging, a process that can increase the risk of age-related diseases. The study analyzed data from 2,346 U.S. adults aged 50 to 84 who participated in a national health survey. Researchers tested their blood and urine for 64 different chemicals, including metals, pesticides, and industrial pollutants. They assessed how these exposures influenced eight different epigenetic aging markers—biological clocks that measure how fast a person's body is aging at the DNA level. "We harnessed data from the National Health and Nutrition Examination Survey 1999-2000 and 2001-2002 cycles to examine exposome-wide associations between environmental exposures and epigenetic aging." The strongest effects were linked to cadmium, a toxic metal found in cigarette smoke and some foods. People with higher levels of cadmium in their blood showed signs of accelerated aging. Higher levels of cotinine, a chemical related to tobacco exposure, were also linked to increased biological age, reinforcing the harmful effects of smoking. Additionally, lead exposure, a heavy metal found in old paint and contaminated water, was also associated with faster aging. The researchers also found that some pollutants, including a type of PCB (PCB118) and a type of dioxin (HpCDD), were linked to slower biological aging. However, it is unclear if this fact is beneficial, as past research shows that slower aging in some cases can still be linked to health risks. This study is one of the largest to investigate how pollution affects the aging process. Unlike previous research that focused on only a few chemicals, it examined a wide range of pollutants in a diverse group of people. The findings suggest that everyday exposure to toxic substances can speed up aging at the cellular level, increasing the risk of age-related diseases. In summary, these findings raise concerns about how widespread environmental contaminants may accelerate aging and contribute to chronic diseases such as heart disease, cancer, and cognitive decline. Reducing exposure to toxic substances like cadmium and lead—found in cigarettes, polluted air, and contaminated food—could help slow biological aging and improve long-term health. These insights highlight the need for stronger environmental health policies to protect individuals from premature aging and disease. DOI - https://doi.org/10.18632/aging.206201 Corresponding author - Andres Cardenas - andresca@stanford.edu Video short - https://www.youtube.com/watch?v=WcL-K399a7M Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts About Aging-US The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population. Please visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

durée : 00:24:03 - Bienvenue chez vous : les spécialistes, ici Alsace - L'exposome, un terme encore méconnu, désigne l'ensemble des facteurs environnementaux auxquels nous sommes exposés tout au long de notre vie. De la pollution de l'air aux substances présentes dans notre alimentation, ces éléments ont un impact direct sur notre santé.

Send us a textDr. Amir Baniassadi, Ph.D. is an Instructor of Medicine at Harvard Medical School and an Assistant Scientist in Marcus Institute for Aging Research ( https://www.marcusinstituteforaging.org/who-we-are/profiles/amir-baniassadi-phd ) where he works on environmental impacts on health and well-being of older populations. Dr. Baniassadi works on the impacts of ambient air temperature and air quality (both indoors and outdoors) on outcomes related to the health and well-being of physiologically and socioeconomically vulnerable populations. His research applies novel environmental modeling and measurement techniques along with remote and long-term physiological and functional monitoring of individuals to establish relationships between exposure and outcome variables of interest outside clinical lab settings. The ultimate goal of his research is to develop environmental interventions that optimize the environment for health and longevity of older adults.Dr. Baniassadi has a Ph.D. in Civil, Environmental, and Sustainable Engineering from Arizona State University and a B.Sc. degree in Mechanical Engineering from the University of Tehran. His post-doctoral training includes a three-year T32 fellowship in Translational Research in Older adults, and a two-year postdoctoral fellowship at Harvard University Graduate School of Design. #AmirBaniassadi #HarvardMedicalSchool #MarcusInstituteForAgingResearch #EnvironmentalGerontology #VulnerabilityScience #Exposome #Health #WellBeing #Wearables #SmartHome #AgingInPlace #Thermoregulation #HeatIslands #ProgressPotentialAndPossibilities #IraPastor #Podcast #Podcaster #Podcasting #ViralPodcast #STEM #Innovation #Science #Technology #ResearchSupport the show

Manish Arora, the CEO and Co-Founder of LinusBio, is developing technologies to measure and analyze the exposome which reveals lifelong exposure to environmental factors. Their platform measures molecular signatures in hair samples for early detection and diagnosis of conditions such as autism, where traditional observational methods can be limited. LinusBio is also exploring the use of the platform for other neurological conditions like ADHD and ALS and gaining a better understanding of the role of environmental exposures in the development of diseases. The company has received Breakthrough Designation from the FDA for its autism biomarker to bring this technology to patients.   Manish explains, "Our genes are static. So if I were to measure your genes when you were a child, or measure them today, I would get the same answer pretty much. Whereas your exposome changes all the time and so does your body's reaction to it. Let me give you a very simple example. A cup of espresso in the morning has a very different reaction to you than a cup of espresso at 9:00 PM at night, which will keep you awake. So even the same environmental input can have a very different reaction within a day."   "So the technical challenge is this: how do we map something that is constantly dynamic? It's always changing in time, and unfortunately, medicine is set with these snapshot technologies. Can that snapshot really give us enough information on what is happening to me? How am I reacting to that environment over the entire year since my last blood test? And that is the big technological challenge facing us as we enter into this arena of exposomes."  "The way we're measuring the exposome is that we've developed a technology where we can map exposures and our response at almost an hourly interval. You get all this data in a few moments in more detail. Using that single strand, we get enough information that would take you a thousand blood tests. There's this massive volume of data. To put a number on it, we just recently generated 50 million data points for each patient in our study. Not all of that signal is easy to decipher. So what we do is we put many, many controls, quality controls in there to say anything below this we do not trust. And these controls have been set in place through years of good scientific practice." "So, going back to the technology to very briefly describe, we open up a strand of hair, and then we start looking inside it using lasers and these detectors that we call mass spectrometers, which can measure thousands of molecular features. So that is what we are measuring. We are measuring molecules in your body."  #LinusBio #Exposome #Biomarkers #Autism #AutismSpectrumDisorder #AutismBiomarker #ADHD #ALS #Metabolism #MedTech  linusbio.com Listen to the podcast here

Manish Arora, the CEO and Co-Founder of LinusBio, is developing technologies to measure and analyze the exposome which reveals lifelong exposure to environmental factors. Their platform measures molecular signatures in hair samples for early detection and diagnosis of conditions such as autism, where traditional observational methods can be limited. LinusBio is also exploring the use of the platform for other neurological conditions like ADHD and ALS and gaining a better understanding of the role of environmental exposures in the development of diseases. The company has received Breakthrough Designation from the FDA for its autism biomarker to bring this technology to patients.   Manish explains, "Our genes are static. So if I were to measure your genes when you were a child, or measure them today, I would get the same answer pretty much. Whereas your exposome changes all the time and so does your body's reaction to it. Let me give you a very simple example. A cup of espresso in the morning has a very different reaction to you than a cup of espresso at 9:00 PM at night, which will keep you awake. So even the same environmental input can have a very different reaction within a day."   "So the technical challenge is this: how do we map something that is constantly dynamic? It's always changing in time, and unfortunately, medicine is set with these snapshot technologies. Can that snapshot really give us enough information on what is happening to me? How am I reacting to that environment over the entire year since my last blood test? And that is the big technological challenge facing us as we enter into this arena of exposomes."  "The way we're measuring the exposome is that we've developed a technology where we can map exposures and our response at almost an hourly interval. You get all this data in a few moments in more detail. Using that single strand, we get enough information that would take you a thousand blood tests. There's this massive volume of data. To put a number on it, we just recently generated 50 million data points for each patient in our study. Not all of that signal is easy to decipher. So what we do is we put many, many controls, quality controls in there to say anything below this we do not trust. And these controls have been set in place through years of good scientific practice." "So, going back to the technology to very briefly describe, we open up a strand of hair, and then we start looking inside it using lasers and these detectors that we call mass spectrometers, which can measure thousands of molecular features. So that is what we are measuring. We are measuring molecules in your body."  #LinusBio #Exposome #Biomarkers #Autism #AutismSpectrumDisorder #AutismBiomarker #ADHD #ALS #Metabolism #MedTech  linusbio.com Download the transcript here

Dr. Mark Hyman is a renowned physician, bestselling author, and leading voice in functional medicine. As the founder of The UltraWellness Center and a senior advisor for the Cleveland Clinic's Center for Functional Medicine, he focuses on addressing the root causes of chronic disease. Dr. Hyman has authored numerous bestselling books on health and nutrition, including Food Fix and The Pegan Diet, and is a passionate advocate for food as medicine. Through his work, he empowers individuals to achieve optimal health through personalized and holistic approaches. In our conversation, we discuss:(00:46) - Dr. Hyman's Opinion on Longevity(09:13) - Functional Medicine(10:30) - Reversing Biological Age(16:22) - Anabolic Resistance(18:00) - Dr. Hyman's Fasting(18:52) - Metformin(20:54) - Longevity Switches(23:00) - Mitochondria Health(25:00) - Metabolic Health(27:24) - Reference Ranges(29:37) - What Are the Most Important Tests We Can Request For(34:07) - Growing Cancer Rate(37:44) - American Diet Problem(38:50) - Epigenetic Changes(40:40) - Exposome(42:05) - Ultra-Processed Foods(45:20) - Principles(45:50) - Superfoods(53:10) - Testosterone's Impact on Longevity(55:10) - Fats(55:32) - Personalized Medicine(57:35) - Fluoride Levels(1:00:18) - Functional Health Learn more about Dr. Hyman:https://drhyman.com/ GET EARLY ACCESS TO FUNCTION! Use code GROWTHMINDS100 to skip the 400,000+ waitlist and be one of the first 100 to join. Sign up now: https://my.functionhealth.com/signup?code=GROWTHMINDS100 Act fast—spots are limited! Watch full episodes on:https://www.youtube.com/@seankim Connect on IG:https://instagram.com/heyseankim

In this episode of UNLOCKED, we sit down with Parneet Pal, a Harvard- and Columbia-trained physician and founder of Systematically Well Advisory, Inc., to uncover the roots of holistic well-being and the transformative potential of lifestyle medicine. Parneet shares pivotal “crucible moments” that redefined her view on health, shaped by her journey from traditional medicine to a focus on lifestyle, our biology, and planetary health. Through fascinating discussions on resilience, well-being, and leadership in the workplace, she brings actionable insights to balance growth and repair within our bodies and workplaces. Join us as we explore how each choice we make is a step toward building a thriving and healthy life—one that is deeply regenerative for ourselves, our communities, and the planet.Key Moments:00:02:01 – Parneet's Journey: Parneet shares her shift from traditional medicine to lifestyle wellness.00:08:01 – True Health Defined: Parneet expands on holistic health and the "exposome."00:15:01 – Homeostasis & Energy: Discussing how cellular energy signals well-being.00:21:01 – Lifestyle Medicine Basics: Key lifestyle factors for balancing health.00:28:01 – Nature's Model: Insights from nature on sustainable well-being.00:38:01 – Workplace Well-being: Parneet on burnout and productivity in businesses.00:46:01 – Leadership & Change: How leaders can support team well-being.00:52:01 – Systematically Well Programs: Overview of Parneet's wellness programs for teams.00:56:01 – Closing Reflection: Parneet's favorite quote on creating a life that fosters life.About Parneet:Parneet Pal, MBBS, MS is a Harvard- and Columbia-trained physician-educator who teaches skills and communicates ideas that advance personal, workplace and planetary health.As the Founder of Systematically Well Advisory Inc., she works with business teams and global organizations to address leadership, performance, wellbeing and sustainability using evidence-based strategies from lifestyle medicine, neuroscience, behavioral science and psychology.Previously, she designed preventive wellbeing programs for Executive Health (including at the University of California, San Francisco), and led faculty, curriculum and content development as the Chief Science Officer of a health start-up scaling corporate mental wellbeing.Parneet speaks about the connections between Health, Leadership and Sustainability at global conferences and guest lectures at several universities. She has been a TEDMED scholar, Harvard Business Review contributor and has been featured on the cover of Mindful magazine.Connect with Parneet:Website: www.parneetpal.comLinkedIn: www.linkedin.com/in/parneetpalInstagram: @pal.parneetConnect with Owl & Key:Website: www.owlandkey.coInstagram: www.instagram.com/owl_and_key/Everything Else: linktr.ee/owlandkey

There is a study of the fascinating interplay between the cumulative effects of external exposures on our body and our genes. It is called exposomics. Learn why we need to recognize that we're exposed to hundreds or thousands of chemicals per day, and why it's important to study that complexity. Featured experts are Dr. Konstantinos Lazaridis, Director of Center for Individualized Medicine at Mayo Clinic; and Dr. Gary Miller, Vice Dean of Research Strategy and Innovation of Mailman School of Public Health and Director of the Center for Innovative Exposomics at Columbia University. 

Get in the know about female bioidentical hormone replacement therapy! therapy:https://www.udemy.com/course/draft/5505730/?referralCode=C418EDF9C393C5716D9EDiscover how your exposome—the sum of all your life's exposures—shapes your genetic expression and, in turn, your health. You can direct your genetic expression by controlling your exposome, making lifestyle changes that profoundly influence your health outcomes. From nutrition to stress management, exercise, and more, learn how to upgrade your operating system for a healthier, more vibrant life. Your health and longevity are worth the investment, and this episode provides the guidance you need to age with confidence and embrace the future with enthusiasm.My Website: www.heatlhcouragecollective.comExposome Journal Article: https://pubmed.ncbi.nlm.nih.gov/21081972/

Michelle Kelly-Irving, Director of Research at the Center for Epidemiology and Population Health Research, Faculty of Medicine, Paul Sabatier University, Toulouse, France, joins Jonathan to discuss social, economic, minority, and gender inequalities across healthcare systems and the life-course; her epidemiological research projects; and the concept of the exposome, highlighting  how environmental exposures impact biology and human health.   Use the following timestamps to navigate the content in this episode: (00:00)-Introduction (02:12)-A diverse upbringing and disciplinary mix (04:20)-Social determinants of biology (06:12)- The exposome (09:26)-Falling down the rabbit hole (11:47)-Gender and health inequalities (15:00)-Man flu! (19:52)-Social deprivation and COVID (25:35)-Health trajectories and influencing people earlier in life (28:16)-Three wishes

Transcript Eric Topol (00:00):This is a real great opportunity to speak to one of the most impressive medical informaticists and leaders in AI in the United States and worldwide. Dr. John Halamka, just by way of background, John, his baccalaureate in Stanford was at U C S F/Berkeley for combined MD PhD trained in emergency medicine at U C L A. He went on to Harvard where he, for 20 years was the Chief Information Officer at Beth Israel Deaconess. And then in 2020 he joined Mayo Clinic to head its platform to help transform Mayo Clinic to be the global leader in digital healthcare. So welcome, John. It's so great to have you. And by the way, I want to mention your recent book came out in April, one of many books you've written, redefining the Boundaries of Medicine, the High Tech High Touch Path into the Future.John Halamka (01:00):Well, a thrilled to be with you today, and you and I need to spend more time together very clearly.Eric Topol (01:06):Yeah, I really think so. Because this is the first time we've had a one-on-one conversation. We've been on panels together, but that's not enough. We've got to really do some brainstorming, the two of us. But first I wanted to get into, because you have been on a leading edge of ai and Mayo is doing big things in this space, what are you excited about? Where do you think things are right now?John Halamka (01:35):So you and I have been in academic healthcare for decades, and we know there's some brilliant people, well-meaning people, but sometimes the agility to innovate isn't quite there, whether it's a fear of failure, it's the process of getting things approved. So the question of course is can you build to scale the technology and the processes and change policies so that anyone can do what they want much more rapidly? And so what's been exciting over these last couple of years at Mayo is we started with the data and we know that anything we do, whether it's predictive or regenerative, starts with high quality curated data. And so by de-identifying all the multimodal data of Mayo and then working with other partners around the world to create a distributed federated approach for anyone to train anything, suddenly you're empowering a very large number of innovators. And then you've seen what's happened in society. I mean, culturally, people are starting to say, wow, this ai, it could actually reduce burden, it could democratize access to knowledge. I actually think that yes, there need to be guidelines and guardrails, but on the whole, this could be very good. So here we have a perfect storm, the technology, the policy, the cultural change, and therefore these next couple of years are going to be really productive.Implementing a Mayo Randomized AI TrialEric Topol (02:59):Well, and especially at Mayo, the reason I say that is not only do they recruit you, having had a couple of decades of experience in a Harvard program, but Mayo's depth of patient care is extraordinary. And so that gets me to, for example, you did a randomized trial at Mayo Clinic, which there aren't that many of by the way in AI where you gave E C G reading power of AI to half the primary care doctors and the other half you didn't for determining whether the patients had poor cardiac function that is low ejection fraction. And now as I understand it, having done that randomized trial published it, you've implemented that throughout the Mayo Clinic system as far as this AI ECG support. Is that true?John Halamka (03:56):Well, right, and let me just give you a personal example that shows you how it's used. So I have an SVT [supraventricular tachycardia] , and that means at times my resting heart rate of 55 goes to one 70. It's uncomfortable. It's not life-threatening. I was really concerned, oh, may I have underlying cardiomyopathy, valvular disease, coronary artery disease. So Paul Friedman and Peter Newsworthy said, Hey, we're going to take a six lead ECG wearable, send it to your home and just record a bunch of data and your activities of daily living. And then we buy 5G cell phone. We'll be collecting those six leads and we'll run it through all of our various validated AI systems. And then we'll tell you based on what the AI suggests, whether you're at high risk or not for various disease states. So it says your ejection fraction 70%. Oh, good. Don't have to worry about that. Your likelihood of developing AFib 3% cardiomyopathy, 2% valvular disease, 1%. So bottom line is without even going to a bricks and mortar facility here, I have these validated algorithms, at least doing a screen to see where maybe I should get additional evaluation and not.Eric Topol (05:12):Yeah, well see what you're bringing up is a whole other dimension. So on the one hand that what we talked about was you could give the primary care doctors who don't read electrocardiograms very well, you give them supercharged by having a deep learning interpretation set for them. But on the other, now you're bringing up this other patient facing story where you're taking a cardiogram when somebody's perfectly fine. But from that, from having deep learning of cardiograms, millions of cardiograms, you're telling what their risks are that they could develop things like atrial fibrillation. So this is starting to span the gamut of what the phase that we went through or still going through, which is taking medical images, whether it's a cardiogram or a scan of some sort, and seeing things with machines that humanize really can't detect or perceive. So yeah, we're just starting to get out of the block here, John. And you've already brought up a couple of major applications that we were not even potentially used three, four or five years ago that Mayo Clinics leading the charge, right?The Power of Machine EyesJohn Halamka (06:26):Well, yeah, and let me just give you two quick other examples of these are in studies now, right? So they're not ready for active patient use. The animate GI product does an overread of endoscopy. And what we're finding is that the expert human, I mean anywhere in the world, expert humans miss about 15% of small polyps. They're just hard to see. Prep may not be perfect, et cetera. The machine misses about 3%. So that's to say a human augmented with overread is five times better than a human alone pancreatic cancer, my father-in-law died about 11 years ago of stage four pancreatic cancer. So this is something that I'm very sensitive about, very often diagnosed late, and you can't do much. What we've been able to see is looking at pancreatic cancer, early films that were taken, abdominal CT scans and these sorts of things, algorithms can detect pancreatic cancer  two years before it is manifested clinically. And so here's the ethical question I'll pose to you. I know you think about a lot of this Scripps Mayo, UCSF, Stanford, we probably have thousands and thousands of abdominal CTs that were read normal. Is it an ethical imperative as these things go through clinical trials and are validated and FDA approved to rerun algorithms on previous patients to diagnose disease we didn't see?Eric Topol (08:03):Well, that is a really big important question because basically we're relieving all this stuff on the table that doesn't get diagnosed, can't be predicted because we're not even looking for it. And now whether it's retina, that is a gateway to so many systems of the body, or as you're mentioning various scans like an abdominal CT and many others that like mammography for heart disease risk and all sorts of things that weren't even contemplated that machine eyes can do. So it's really pretty striking and upending cancer diagnosis, being able to understand the risk of any individual for particular types of cancer so that you can catch it at the earliest possible time when it's microscopic before it spreads. This, of course, is a cardinal objective. People don't die of cancer per se. They die of its metastasis, of course, for the most part. So that gets me now to the next phase of ai because what we've been talking for mostly so far has been what has been brewing culminating for the last five years, which is medical images and what, there's so many things we can glean from them that humans can't including expert humans in whatever discipline of medicine.Multimodal AI and Social Determinants of Health(09:19):But the next phase, which you are starting to get at is the multimodal phase where you're not just taking the images, you're taking the medical records, the EHRs, you're getting the genomics, the gut microbiome, the sensors. You mentioned one, an ECGs, a cardiogram sensor, but other sensors like on the wrist, you're getting the environmental things like air pollution, air quality and various things. You're getting the whole ball of wax any given individual. Now, that's kind of where we're headed. Are you doing multimodal ai? Have you already embarked in that new path? Now that we have these large language modelsJohn Halamka (10:02):And we have, and so like anything we do in healthcare innovation, you need a Pareto diagram to say, what do you start with and where do you go? So in 2020, we started with all of the structured data problems, meds, allergies, labs. Then we went to the unstructured data, billions of notes, op reports, H and Ps, and then we moved to telemetry, and then we moved to CT, MRI, PET. Then we move to radiation oncology and looking at all the auto contouring profiles used in linear accelerators and then to omic, and now we're moving to an inferred social determinants of health. And let me explain that for a minute.(10:45):Exposome, as you point out, is really critical. Now, do you know if you live in a Superfund site area, do you know what risks you might have from the PM 2.5 particulates that are blowing through San Diego? Probably you don't. So you're not going to self-report this stuff. And so we have created something called the house Index where we've taken every address in the United States, and based on the latitude and longitude of where you live, we have mapped air, water, land, pollution, access to primary care, crime, education, grocery stores, stores, and therefore we can infer about 40 different things about your expose em just from where you live. And that's a mode. And then as you say, now, starting to gather remote patient monitoring. We have this acute advanced care in the home program where we're taking serious and complex illness, caring for the patient in the home, starting to instrument homes and gather a lot more telemetry. All of that multimodal data is now available to any one of the 76,000 employees of Mayo and our partners for use in algorithm development.Eric Topol (11:58):Yeah, no, that's extraordinary. And I also would say the social determinants of health, which you've really gotten into as its importance. There are so many papers now over the last several years that have emphasized that your zip code is one of the most important things of your health. And it's not even just a zip code. It's your neighborhood within that zip code for the reasons that you've mentioned. And inferring that and imputing that with other sources of data is vital. Now, this multimodal, you've again anticipated one of my questions, the possibility that we can gut hospitals as we know them today. Yes, preserving the ICUs, the emergency departments, the operating rooms, but those other people that occupy the vast majority of beds in the hospital that are not very sick, critically Ill. Do you think we're going to move as you're innovating at Mayo whereby we'll be able to keep those people at home for the most part in the years ahead? I mean, this isn't going to happen overnight, but do you think that's where we're headed?The Hospital-at-HomeJohn Halamka (13:08):So to date, Mayo and its partners have discharged about 23,000 patients from their homes. And as you can guess, we have done clinical trials and deep dive studies on every one of the patient's journeys. And what have we seen across 23,000 patients? Well, so generally, about 30% of patients that present for acute care to an emergency department come in by ambulance are appropriate for care in non-traditional settings. I mean, I think you would agree, somebody with episodic ventricular tachycardia, you're probably not going to put in a home setting, but somebody with congestive heart failure, COPD, pneumonia, I mean, these are things that, as you say, if they're going to get sicker, it will be over hours, not minutes. And therefore you can adjust in these molar than 20,000 patients. What we've seen is the outcomes are the same, the quality is the same safety, the same patient satisfaction. You get net promoter scores in the mid-nineties. You find me a hospital with a net promoter score in the mid nineties. You're eating your own food, slipping your own bed. Oh, your granddaughter's coming at 2:00 AM on a Sunday, whatever. And then ask yourself this other question, nosocomial infections,Eric Topol (14:31):Right?John Halamka (14:31):How many methicillin resistant staph infections do you have in your office? You're like, none, right? So you're infections in fall, so okay, better, stronger, cheaper, faster. And the safety of the quality are that for about 30% of the population should be a standard of care.Eric Topol (14:56):That's really big. So you don't think we have to do randomized trials to prove it?John Halamka (15:01):I mean, we have done enough studies to date, and there are organizations, Kaiser Permanente, Cleveland Clinic, all these folks who are joining us in investigating these areas. And the data is very compelling.Patients Asking Questions to LLMsEric Topol (15:17):Yeah, that's really exciting. And we may be able to jump past having to go through the large trials to prove what you just reviewed. So that's one thing of course that we're looking for in store. Another is the patient doing advanced large language model searches. So as you and everyone knows, we've done Google searches for years about symptoms, and inevitably people come up with hypochondria because they have some horrible disease that they looked up that is not a very good match specific for their condition and their background. But soon already today, we have people going into being creative mode, G P T four and other searches, and they're getting searches about their diagnosis and about what's the best literature and best treatments and expectations. That won't be FDA regulated. We don't have regulation of Google searches. So how do you see the democratization of large language models with patients having conversations with these chatbots?John Halamka (16:32):And of course, you ask a question no one has answered yet, but here are a few threads. So we know the challenge with existent commercial models as they're trained on the public internet. Some are trained on additional literature like PubMed or a mimic dataset, but none are trained on the rich clinical experience of millions and millions of patients. So therefore, they don't have the mastery of the care journey. So question, we are all asking, and again, no one knows. Then you take a GPT, BARD, a MedPaLM and additional pre-training with rich de-identified clinical experience and make it a better model for patients who are going to ask questions. We've got to try and we've got to try within guardrails and guidelines, but we definitely want to explore that. Can you or should you train a foundational model from scratch so that it doesn't have the bias of Reddit and all of the various kinds of chaff you find on the public internet? Could be very expensive, could be very time consuming. Probably society should look at doing it.Eric Topol (17:50):So this is just a review for those who are not up to speed on this, this means setting up a base model, which could be 20 to 30,000 graphic processing units, big expense. We're talking about tens of millions, but to do it right, so it isn't just a specialized fine tuning of a base model for medical purposes, but something that's de novo intended that no one's done yet. Yeah, that's I think a great idea if someone were to go down that path. Now you, early on when we were talking, you mentioned partners, not just other health systems, but one of the important partners you've established that's been out there as Google, which I think set up shop right in Rochester, Minnesota, so it could work closely with you. And obviously they have MedPaLM2, they have BARD, they published a lot in this space. They're obviously competing with Microsoft and others, but seems like it's mainly an arms race between those two and a few others. But how is that relationship going? And you also were very right spot on about the concerns of privacy, federated ai, privacy computing. Can you tell us about Mayo and Google?What is the Collaboration Between Mayo and Google?John Halamka (19:06):Well, absolutely. So Google provides storage, compute, various kinds of tools like their fire engine for moving data between various sources. Google does not have independent access to any of Mayo's data. So this isn't a situation of we have a challenging medical or engineering problem, bring 60 Google engineers to work on it. No, what they mean is they help us create the tooling and the environment so that then those with permission, Mayo employees or Mayo's partners can work through some of these things and build new models, validate models. So Google has been a great enabler on the tool set and building scale. You probably saw that Eric Horvitz gave a recent grand rounds at Stanford where he explained scale makes a difference, and that you start to see these unexpected behaviors, this emerging goodness, when you start dealing with vast amounts of multimodal data, vast amounts of compute. And so working with a cloud provider is going to give you that vast amounts of compute. So again, privacy, absolutely essential, de-identify the data, protect it, control it, but you can't as an institution, get enough computing power locally to develop some of these more.Towards Keyboard Liberation and Machine Chart ReviewEric Topol (20:36):Well, that goes back to the dilemma about building a base model with just the capital costs no less. You can't even get these GPUs scale because their supply and demand mismatch is profound. Well, the other thing, there's two other areas I want to get your impressions about. One of course is the change of interactions with patients. So today, as you well know, having all these years overseeing the informatics, Beth Israel now Mayo, the issue of the keyboard and the interference that it provides, not just as a data clerk burden to clinicians, which is horrible for morale and all the hours even after seeing patients that have to be put into charting through the EHRs and these clunky software systems that we are stuck with, but also the lack of even having face-to-face eye contact with patients in that limited time they have together. Now, there are many of these so-called ambient AI language, natural language processing, using large language models that are of course turning that conversation not just to a remarkable note, but also of course any part of the note, you could go back to the raw conversation. So it has trust embedded as what was really said. And then you have all these downstream functions like prescriptions, follow-up appointments, nudges to the patients about whatever, like their blood pressure or things that were discussed in the visit. You have translation to the patient at their level of education so they can understand the note you have things that we never had before. You have orders for the test or follow up appointment pre-authorization. What about these, John, are these the real deal or are we headed to this in the near term?John Halamka (22:41):So 10 years ago, I said all of these meaningful use criteria, all the keyboarded data entry, structured data and vocabularies. What if you had the doctor and the patient had a conversation and the conversation was the record? That was the legal record. And then AI systems extracted the structured data from the conversation. And there you would have satisfaction by both patient and doctor and a very easy source of truth. Go back to what was said. And of course, 10 years ago everyone said, that'll never happen. That's too far.(23:20):And so I'll give you a case. My mom was diagnosed with a brain abscess about a year ago. She's a cure of the brain abscess. I with ambient listening, had a conversation with my mother and it went something like this. Yes, I started to develop a fever. I said, oh, and you live alone, right? Oh, yes. My husband died 13 years ago. The note comes out, the patient is an 81 year old widow. So we're having a conversation about my father dying and she lives alone. And I didn't use the word widow, she didn't use the word widow. And so what it shows you is these systems can take detailed conversation, turn them into abstract concepts and record them in a way that's summarized and meaningful. Last example I'll give you recently, I did grand rounds at Mayo and I said, here's a challenge for all of us. It's Sunday at three in the morning. Mrs. Smith has just come in. She has a 3000 page chart, 75 hospitalizations and four or visits. Her complaint tonight is, I feel weak,Eric Topol (24:38):Right? That's a classic.John Halamka (24:43):How are you going to approach that? So we have an instance of MedPaLM2 that is containerized. So that I was able to put a prompt in it with some background data without, and it was all de-identified, but it was all very secure. So I put the 3000 pages into this MedPaLM2 container and said, audience, ask any question that you want. Oh, well, what medication should she be taking? What's her follow-up plan? Were there any complications in any of her surgeries? And within seconds, every answer to every question just appears. They say, oh my God, I can now treat the patient. And so this is real. It is absolutely. It's not perfect, but give us a couple of quarters.Eric Topol (25:31):Yeah, quarters not even years. I think you're putting the finger on something that a lot of people are not aware, which is when you have complex patients like what you just described, that woman, and you have so much information to review, no less the corpus of the medical literature, and you have help with diagnosis treatments that you might not otherwise thought of. It also gets me back to a point I was going to make the machine vision during colonoscopy where it does pick up these polyps, but it was shown that at the end of the day in the afternoon for gastroenterologists that are doing colonoscopies all day, their pickup rate drops down. They get tired, their eyes are just not working as well. And here your machines, they don't get tired. So these things are augmenting the performance of physicians, clinicians across the board potentially.(26:28):And yes, there's a concern as you touched on about confabulation or hallucinations, whatever, but this is a work in progress. There will be GPT-X, BARD-15 or whatever else right now, another area that is hot, which is still very in the earliest nascent stage, is the virtual medical coach. Whereby any of us with all our data, every visit we've ever had, plus our data that's in real time accruing or scans or slides or whatever it is, is all being fed in process with the medical literature and helping us to prevent a condition that we would have high risk to develop or manifest or better management of the various things we do have that we've already declared. What about that, John? Are we going to see virtual medical coaches like the kind we see for going to the airport, or you have an appointment such and such about your daily life, or is that something that is way out there in time?John Halamka (27:37):I know you're going to hate this answer. It depends.Eric Topol (27:41):Okay. I don't hate that. I like it actually. Yeah.John Halamka (27:44):So some years ago, one of my graduate students formed a virtual coaching company, and what he found was patients would often start with a virtual coach, but they wouldn't stick with it because the value add wasn't necessarily there. And that is it wasn't then every day there was something new or actionable. And so if it's few and far between, why do you want to go through the effort of engaging in this? So I think our answer there is we need to make sure that the person who uses it is getting something of value for using it. Reduced insurance rates, free club memberships to a gym, whatever, something of value. So it gets some stickiness.Virtual AI CoachingEric Topol (28:33):Yeah. Well, it's still early and right now, as you well know, it's really confined to certain conditions like diabetes or depression or high blood pressure. But it certainly has the chance in the years ahead to become broad for any individual. And that gets back to the patient scenario that you presented where you had all the data of that woman who presented with weakness as the inputs. And just think about that happening in real time, giving feedback to any given individual, always thinking that it's optional. And as you say, maybe it'd be more elective. There were incentives, and if people don't want it, they don't have to use it, but it's something that's out there dangling as a potential. Well, of the things we've discussed, there are many potential ways that AI can be transformative in the future, both for clinicians, for health systems, for patients. Have I missed anything that you're onto?John Halamka (29:40):Just that in predictive AI, we can judge performance against ground truth. Did you have the disease or not? Did you get a recommendation that was followed up on and it was positive? With generative ai measuring quality and accuracy, doing follow up and oversight is much harder. So I think what you're going to see is FDA and the office of the national coordinator and the White House work through generative AI oversight. It's going to start with, as we've seen voluntary oversight from some of the companies themselves. And it will evolve into maybe some use cases that are considered reasonable practices and others that we defer reasonable practices. Hey, you want an agent that will pre-draft your email and then you just edit it, that's fine. And Mayo is live with that in Epic inbox. How about help you write a letter or help you take, as you say, a very complex medical condition, explain it in eighth grade English or a foreign language. Very good at all of that differential diagnosis, not quite ready yet. And so I think we'll start with the administrative use cases, the things that reduce burden. We'll experiment with differential diagnosis. And I don't think we yet have line of sight to say, actually, we're going to have the generative ai do your diagnosis(31:09):Not there yet,Machines Promoting EmpathyEric Topol (31:10):Right? Perhaps we'll never be, particularly for important diagnoses, maybe for routine things that are not a serious matter. One thing that I didn't anticipate, and I want to get your view. When I wrote deep medicine, I was talking about restoring the patient-doctor relationship and the gift of time that could be garnered from having this machine support. But now we're seeing the evidence that the AI can promote empathy. So for example, reviewing a doctor's note and telling the doctor, you didn't show you're very sensitive. You weren't listening, making suggestions for being a more empathic physician or nurse. Did you foresee that too? Because you've been ahead of the curve on all this stuff.John Halamka (32:04):So here's an interesting question. You and I are physician, scientist, writers. How many physician scientist writers are there? Not so many. So what you get are brilliant math or brilliant science, and it is communicated very badly. So I did not anticipate this, but I'm saying the same thing you are, which is you can take a generative AI and take something that is not very digestible and turn it to something highly readable. And whether that's empathy or clarity or whatever, it actually works really well.Eric Topol (32:43):Yeah. Yeah. I mean, I kind of stunned by this because the machines don't know empathy. They can't feel empathy, but they can promote it. And that's really fascinating. So this has been an uplifting discussion. A lot of the things that's happening now give credit to you that you saw coming long before others, and it's a real joy. So we got to keep up with each other. We got to do some more brainstorming on the things that we haven't discussed today. But thanks so much, John, for joining me and for being such a bright light for the work you're doing with Mayo Clinic as a president of its platform. That's no question. Transforming the future of healthcare.John Halamka (33:25):Well, hey, thanks for having me. And I would say both you and I have taken the digital Hippocratic Oath. We will do no digital harm.Eric Topol (33:33):Love it. Get full access to Ground Truths at erictopol.substack.com/subscribe

Mathilde TouvierSanté publique 2022-2023Collège de FranceColloque - Nutritional Determinants of Health: Recent Research Discoveries and Translation into Public Health Action : An Exposome Perspective of Food ToxicologyIntervenant(s)Pr Robert Barouki, Professor Université Paris CitéRésuméThe exposome represents the set of exposures that can influence human health throughout life. It includes, according to Chris Wild, the external physical exposures, the psychological and social context and the regulations of the internal environment. This new concept actually encompasses all risk factors of non-genetic origin. The diet is one of the major vectors of the chemical exposome. Additional contributions followed that of Wild, specifying in a more concrete way what the exposome could correspond to. Price et al. have defined the functional exposome as corresponding to the biological impacts of the exposome. Thus bridges have been built between exposome and toxicology with the objective of 1) developing an integrated analysis of the various stresses (mixture of chemical substances, interaction diets and exposure to chemical substances, interaction between psychosocial stresses and chemical substances taking into account long-term and potentially multi-generational effects; 2) strengthen the study of the impact of environmental factors on epigenetic regulations and eventually develop epigenotoxicity tests; 3) introduce the exploration of the exposome in clinical medicine (dietary contamination, indoor air, work environment, endocrine disruptors, etc.).Robert BaroukiRobert Barouki, MD, PhD, is Professor of Biochemistry at Université Paris Cité and head of the Inserm unit T3S: "Toxicology, Therapeutic Targets, cellular Signaling and Biomarkers". He also heads the clinical metabolomics and proteomic biochemistry laboratory at the Necker Enfants malades hospital. His research is focused on the impact of environmental contaminants on human health, in particular POPs and EDCs and more generally on the links between the exposome and health. He is involved in several EU projects: HBM4EU and PARC (linking exposure to health), Heals and Neurosome (exposome), HERA (setting the research agenda in environment and health) and Oberon (EDC testing). He has also been involved in the networking of French and European research in the field of environment and health as well as in communicating scientific data to citizens.

“The unifying theme across our portfolio is that whatever a company we invest in is building can make a population-level health impact. For us, that means that what they're doing is going to lead to innovation that is ultimately accessible to huge portions of the global population,” says Gurdane Bhutani, co-founder and managing partner of MBX Capital, a venture capital partnership dedicated to investing in early-stage companies focused on big public health problems. As he explains to host Shiv Gaglani, that ambitious mission is focused on three main themes: accumulated environmental exposure (exposome), biosecurity and biodefense, and healthcare infrastructure. “The majority of disease pathogenesis today is environmental in nature, not genetic. So we're looking at companies that are developing exposomic sequencing technologies that help us better understand these environmental exposures.” One such company is using human-relevant tissue models to test for environmental contaminants. Others include a nurse scheduling platform and a firm that's localizing radiology systems for underdeveloped areas. Bhutani has a track record of investing in interesting and impactful companies in healthcare (in fact, he was an early backer of Osmosis!) so you won't want to miss his insightful perspective on promising ideas for improving health and healthcare systems.Mentioned in this episode: https://www.mbxcapital.com/

Autoimmune conditions are exponentially on the rise. Toxic exposures, declining food quality, stress, and unhealthy lifestyle factors are all contributors. Dr. Akil Palanisamy is a Harvard-trained physician, author, and holistic medicine expert in integrative and functional medicine. Through years of experience in root-cause medicine, he's helped thousands of patients find relief and remission of autoimmune diseases. Dr. Akil's new book The T.I.G.E.R. Protocol: An Integrative, 5-Step Program to Treat and Heal Your Autoimmunity outlines his approach using the best of conventional and holistic medicine. In today's episode, we meet Dr. Akil Palanisamy. We discuss his treatment strategies and successes in addressing autoimmunity as outlined in his new book The T.I.G.E.R. Protocol. Today on The Lab Report: 3:45 Akil Palanisamy combines integrative and holistic medicine with Ayurveda 7:20 Common misconceptions and the paleovedic diet 8:25 The rise of autoimmunity – remission vs. cure 10:35 The T.I.G.E.R. Protocol – autoimmunity treatment and prevention 14:06 Exposome and detox 15:35 Infection, gut health, and autoimmunity 20:00 Phase 1 - Phase 2 Diet, processed food quality 24:30 Rest, recovery, and stress 26:00 Success stories, mitigating pharmaceuticals, remission 27:35 The Fireball Additional Resources: The T.I.G.E.R. Protocol doctorakil.com Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week's episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don't forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: podcast@gdx.net. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.See omnystudio.com/listener for privacy information.

@michaelsalzle

Today we are talking about the exposome. This is a crucial topic that needs to be discussed. Once you understand this concept – and I get that it may not sound like a sexy topic. But trust me – once you understand this - you can't unlearn it – it will be lifechanging. We're first going to define what exactly is the exposome. Then we're going to discuss the ramifications of the exposome – why does it matter - and finally we're going to talk about what you can do to improve your odds. Just a quick disclaimer that this podcast is meant for educational purposes only and is not meant to diagnose or be a substitute for medical advice from your practitioner. **Follow me on Instagram: https://www.instagram.com/thefunctionalnursepractitioner/ ** Level up your products: https://www.ewg.org/ewgverified/ **Interesting articles for more information** The Exposome and Toxicology: A Win–Win Collaboration: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019839/pdf/kfab149.pdf Associations between the Maternal Exposome and Metabolome during Pregnancy: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901044/pdf/ehp9745.pdf The Exposome Paradigm to Understand the Environmental Origins of Mental Disorders: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9590645/pdf/ap-22-4-171.pdf Addressing Exposome: An Innovative Approach to Environmental Determinants in Pediatric Respiratory Health : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9237327/pdf/fpubh-10-871140.pdf Epigenetic Regulation in Exposome-Induced Tumorigenesis: Emerging Roles of ncRNAs: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032613/pdf/biomolecules-12-00513.pdf Exposome and Immunity Training: How Pathogen Exposure Order Influences Innate Immune Cell Lineage Commitment and Function: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697998/pdf/ijms-21-08462.pdf Advancing tools for human early lifecourse exposome research and translation (ATHLETE): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8683140/pdf/ee9-5-e166.pdf The Socio-Exposome: Advancing Exposure Science and Environmental Justice in a Post-Genomic Era: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604315/pdf/nihms838202.

The exposome refers to the sum of genetic, environmental and lifestyle factors that contribute to skin aging, the physiological process responsible for the appearance of wrinkles, loss of elasticity, irregular pigmentation, skin signs collectively described as photoaging. Photo- a reference to the sun's UVA and UVB rays that cause cell damage, the root cause of skin aging. Or is it? In this podcast episode, I tell a story about beauty and the light. Want more of our podcast? Episode Recaps and Notes: https://www.scienceofbeauty.net/; Instagram: @drteowanlin; Youtube: http://bit.ly/35rjbve; https://phygiartbeauty.com/newsletter/ If you enjoyed this podcast, we would love that you leave us a 5 star rating so more people can hear it! For more skincare tips visit: https://asianbeautywhispers.com/; https://drtwlpharmacy.com/podcast-2/

We shared this episode with doctor and musician Rupa Marya. While society requires us to pick just one path for our professional life, we need to give ourselves permission to choose many paths and find a way to make it our own. Music and Medicine are not separate, arguably, their separation might be one of the reasons we live in a sick society and a sick planet. Deep Medicine is an acknowledgment that health is really a phenomenon that emerges out of systems harmonizing well together so it specifically requires an analysis of power and an understanding of how structures are set in place that predispose certain groups to poor health. The “social determinants of health” do help in showing these relationships but they lack a deeper level of analysis, exposition and even activism. We also spoke about Death and Grieving as portals for regeneration; about the Exposome and the way that collective stories are part of it; and about the richness of ancestral knowledge and how to make space for it to co-evolve with our modern western cosmologies. Rupa´s projects can be found on her website and her book Inflamed. Dr. Rupa Marya is a physician, activist, writer, mother and composer. She is an Associate Professor of Medicine at the University of California and a co-founder of the Do No Harm Coalition. Her work sits at the nexus of climate, health and racial justice. She is the co-author of the book Inflamed: Deep Medicine and the Anatomy of Injustice.

L'impact des facteurs environnementaux sur les jeunes enfants Les brèves du jour Steve Pascolo, un spécialiste de l'ARN messager

Our health and susceptibility to disease are not wholly written in our genes. They are influenced throughout our lives by the environments in which we live, through our exposures to chemical agents, the infections we experience, to the psychosocial stresses of daily life. This appreciation of the role our environment plays in shaping our health and wellbeing is encompassed in the concept of the exposome, bringing together advanced statistical methods, exposure science and modern multi-omic techniques to better understand disease development and exacerbation. A lecture by Ian MudwayThe transcript and downloadable versions of the lecture are available from the Gresham College website: https://www.gresham.ac.uk/watch-now/exposomeGresham College has offered free public lectures for over 400 years, thanks to the generosity of our supporters. There are currently over 2,500 lectures free to access. We believe that everyone should have the opportunity to learn from some of the greatest minds. To support Gresham's mission, please consider making a donation: https://gresham.ac.uk/support/Website:  https://gresham.ac.ukTwitter:  https://twitter.com/greshamcollegeFacebook: https://facebook.com/greshamcollegeInstagram: https://instagram.com/greshamcollege

Cliquez ici pour découvrir ce qu'est l'exposome des enfants, et ce qu'on peut en tirer pour nos actions de parents (santé-environnement). L'article L'exposome des enfants, un concept utile pour les parents est apparu en premier sur Santé des Enfants et Environnement.

Quelle est l'importance des facteurs environnementaux dans la Polyarthrite Rhumatoïde ? Quel est l'impact de ces facteurs sur la survenue de la maladie et/ou de ses poussées ? Sur quels facteurs environnementaux externes est-il possible d'agir ? Comment agir au niveau des facteurs intrinsèques ? Comment intégrer les facteurs environnementaux dans la prise en charge de la Polyarthrite Rhumatoïde ? Le Pr Luca Semerano, rhumatologue au sein du service de Rhumatologie de l'Hôpital Avicenne à Bobigny, répond à vos questions.   Invité : Pr Luca Semerano – Hôpital Avicenne – Bobigny https://www.aphp.fr/service/service-22-095  Le Pr Semerano déclare ne pas avoir de lien d'intérêt en rapport avec le sujet traité.   L'équipe :
 Comité scientifique : Pr Jérémie Sellam, Pr Thao Pham, Dr Catherine Beauvais, Dr Sophie Hecquet, Dr Céline Vidal Animation :  Pyramidale Communication Production : Pyramidale Communication Soutien institutionnel : Pfizer   Crédits : Pyramidale Communication, Sonacom

In this episode, Emily speaks with physician Rupa Marya and political economist Raj Patel about their recent book Inflamed: Deep Medicine and the Anatomy of Injustice, which explores the impact of oppressive systems on our health, and how deep medicine can facilitate collective healing. The Nocturnists is partnering with VCU Health Continuing Education to offer FREE CME credits for healthcare professionals. Visit ce.vcuhealth.org/nocturnists to claim credit for this episode. Find show notes, transcript, and more at thenocturnists.com.

In light of the ongoing, world-wide death rate attributed to Covid-19, combining a healthy lifestyle with recognized medical interventions – vaccines and medications – is critical to address the current and future pandemics. Healthy interventions include physical activity, following an anti-inflammatory eating plan – emphasizing fruits, vegetables, omega-3 fish (Mediterranean diet) - minimizing the effects of Covid-associated stress (diminished social interaction), and developing healthy sleep patterns. These interventions can go a long way to support people with obesity, hypertension, diabetes, and pulmonary dysfunction, who are at higher risk of Covid severity.Researchers from Spain, reporting in the December online issue of the peer-reviewed journal Nutrients, highlight the role how holistic lifestyles interventions have proven to attenuate the effects of Covid-19 in the “exposome” – life-course exposures starting from the prenatal period onward.Roughly one-quarter of the world's population is considered inactive – not achieving 150 minutes of weekly, moderate activity, or 75 minutes of vigorous activity.  Social distancing and lockdowns have only acerbated inactivity out of necessity. The Spanish researchers comment that, “regular PA (physical activity) is associated with a 31% and 37% risk reduction of community-acquired infectious diseases and subsequent mortality, respectively, compared to inactive controls.”  According to their investigation, The Exposome and Immune Health in Times of the COVID-19 Pandemic, “even just four weeks of either moderate-or high- intensity interval exercise can lead to a remarkable improvement in natural killer (NK) cell number and function (i.e., ‘killing capacity').” The researchers further site evidence that, “elderly women who were physically active had a better immune response after vaccination than those who were less active.”From a body weight management perspective, the worldwide prevalence of obesity has almost tripled since 1975, with 39% and 13% of adults now considered to have overweight and obesity, respectively. There is meta-analytical evidence, “that individuals with obesity are not only at greater risk of COVID-19 infection, but also of having a worse prognosis (higher risk of severe disease and mortality) than their normal-weight peers,” note the Spanish researchers. The researchers conclude that, “body weight management should be a key public health concern in the prevention/management of the current COVID-19 pandemic.”Research have proven that when overweight individuals switch from a 14-hour eating window to ten to an eleven-hour eating duration over 16 weeks, they reduce their energy intake by 20% and demonstrated a reduction in body weight.Simply stated, “due to its antioxidant, anti-inflammatory and immunomodulatory benefits, and its protective effect against predictors of morbidity and mortality in patients with COVID-19, such as CVD (cardiovascular disease), the Mediterranean diet could be a promising and relatively easy-to-apply method to attenuate the severity of SARS-CoV-2 and eventual future viral pandemics.”While micronutrients, such as Vitamins A, C, B complex, and the minerals zinc and selenium deserve immune support recognition relative to Covid-19, Vitamin D may stand alone for its ability to provide adaptive and innate immune support. In fact, “there is evidence suggesting that vitamin D supplementation can have a positive effect on COVID-19 symptoms and severity. Compared with a lower dose (1000 IU), daily oral supplementation with 5000 IU of vitamin D3 for two weeks reduced the time to recovery of symptoms such as cough and gustatory sensory loss among mild-to-moderate COVID-19 patients with sub-optimal vitamin D status.”Sleep disturbances have emerged, as a consequence of the Covid-19 pandemic – due in p

Dr. Mario Thevis is Professor and head of the Centre for Preventive Doping Research at the German Sport University of Cologne. He is also Director of the European Monitoring Center for Emerging Doping Agents (EuMoCEDA), a forensic chemist, Editor and Chief of the journal Drug Testing and Analysis, and a Research Scientist with the Partnership for Clean Competition. In this episode, Mario discusses new research focusing on the athlete exposome.

This week's podcast focuses on the aging skin exposome, a fairly recent concept in dermatology research which explains the physiological processes that result in skin aging. The skin exposome encompasses external environmental factors as well as internal, biological responses which also includes the use of cosmeceutical interventions. The SkinCeuticals C E Ferulic serum represents the gold standard of an antioxidant vitamin C serum, formulated according to the Duke antioxidant patent, with specific parameters that make it an ideal formulation. Want more of our podcast? Episode Recaps and Notes:https://www.scienceofbeauty.net/; Instagram: @drteowanlin; Youtube: http://bit.ly/35rjbve This educational episode is presented by SkinCeuticals in conjunction with www.scienceofbeauty.net.

It's our first ever repeat guest! Dr. Aviva Romm is such a rich source of expertise that we had to have her back to talk about all things related to HORMONES! In this episode, she and Adrienne discuss everything you ever wanted to know about women's hormones, from concerning signs and symptoms to actionable ways to bring your hormones back into balance. Listen to learn the line between "normal" and abnormal hormonal symptoms, what factors can lead to hormone imbalances, the little-known field of science that may have the biggest impact on your hormonal health, natural ways to rebalance your hormones, and more. Join the conversation at the written version of the article here: https://getwellbe.com/aviva-romm-exposome-hormonal-irregularities

Michael Snyder Dr. Michael Snyder is the director for the Center for Genomics and Personalized Medicine at Stanford and a pioneer and advocate of "deep profiling." Deep profiling seeks to apply intelligent analysis to large data sets to yield specialized clinical insight, ranging from common consumer-grade wearables like Apple Watches to whole-body MRI, continuous glucose monitoring, and metabolomics. In this episode, you'll discover: 00:12:51 - Continuous glucose monitors 00:31:04 - Lyme disease 00:34:00 - Predicting illness with smartwatches 00:39:14 - Heart rate variability 00:40:41 - Exposome and airborne pollutants 00:51:04 - Discovering Ageotypes 00:58:05 - Exercise benefits 01:03:11 - Michael Snyder's lifestyle habits   If you're interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/michael-snyder Join over 300,000 people and get the latest distilled information on personalized medicine straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A's with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

Dr. Michael Snyder is the director for the Center for Genomics and Personalized Medicine at Stanford and a pioneer and advocate of "deep profiling." Deep profiling seeks to apply intelligent analysis to large data sets to yield specialized clinical insight, ranging from common consumer-grade wearables like Apple Watches to whole-body MRI, continuous glucose monitoring, and metabolomics. Chapters: 00:12:51 - Continuous glucose monitors 00:31:04 - Lyme disease 00:34:00 - Predicting illness with smartwatches 00:39:14 - Heart rate variability 00:40:41 - Exposome and airborne pollutants 00:51:04 - Discovering Ageotypes 00:58:05 - Exercise benefits 01:03:11 - Michael Snyder's lifestyle habits Get this show's notes, timeline, and transcript:https://www.foundmyfitness.com/episodes/michael-snyder Dr. Snyder's faculty bio page:https://profiles.med.stanford.edu/michael-snyder Dr. Snyder on Twitter:https://twitter.com/SnyderShot COVID-19 Tracking Study:https://innovations.stanford.edu/wearables Free metabolism SNP report for consumer genetic data:https://www.foundmyfitness.com/genetics/metabolism

Ohio State University's Darryl B. Hood reveals how a database with about 25,000 environmental factors and variables associated with the public health exposome may soon lead to major breakthroughs in addressing disparate public health outcomes in various communities. He also shares with co-hosts Anne Chappelle and David Faulkner his experiences from a lifetime of firsts—from being a plaintiff in Brown v. Board of Education to transitioning from an HBCU (historically black college and university) to a program where he was the only Black man. About the GuestDarryl B. Hood, PhD, is an Associate Professor and environmental neuroscientist in the Division of Environmental Health Sciences in the Ohio State University College of Public Health. Dr. Hood received a BS in biology and chemistry from Johnson C. Smith University in Charlotte, North Carolina, and a PhD in biochemistry from the Quillen-Dishner College of Medicine at East Tennessee State University. After completing a postdoctoral fellowship at the Center in Molecular Toxicology at Vanderbilt University School of Medicine in 1993, Dr. Hood accepted a position at Meharry Medical College and served meritoriously until 2013 on the faculty of both Meharry Medical College and Vanderbilt University School of Medicine in the Department of Pharmacology and Neuroscience. During this time, he received over $11.2 million dollars of research funding. From 2006 to 2011, Dr. Hood led what has come to be known as the most successful Minority S11 NIEHS-sponsored initiative, referred to as the Advanced Research Cooperation in Environmental Health (ARCH) Program. The research conducted under this consortium ultimately contributed to the scientific database that the US Environmental Protection Agency (US EPA) used to reassess the levels of polycyclic aromatic hydrocarbon emissions from smokestacks. Such reassessments have resulted in public policy changes that will serve to decrease the adverse health effects associated with environmental exposures. The Meharry Medical College-Vanderbilt University ARCH Consortium was recognized as being at the interface of successful P01-like research programs in general, and for systems toxicology research in particular. This construct served as the template that then–NIH Director Dr. Elias A. Zerhouni used as the viable, futuristic model for the development of effective scientist-to-scientist interactions between research-intensive universities and historically black colleges and universities.At the Ohio State University, Dr. Hood has continued his innovation in discovery as the co-architect of the novel Public Health Exposome framework. This paradigm-altering framework interrogates hypotheses focused on determining if there are associations between the built, natural, and social environments and disparate health outcomes observed in vulnerable populations. Collectively, Dr. Hood has 105 peer-reviewed publications, including book chapters, and has mentored over 15 MSPH/MPH candidates, 15 PhD candidates, and nine postdoctoral fellows. He continues to serve on numerous editorial and review boards for scientific journals, government agencies, and academia. Most recently, from 2010 to 2016, he served on the US EPA Exposure and Human Health Subcommittee of the Science Advisory Board.DisclaimerThe viewpoints and information presented in Adverse Reactions represent those of the participating individuals. Although the Society of Toxicology holds the copyright to the production, it does not vet or review the information presented, nor does presenting and distributing the Adverse Reactions podcast represent any proposal or endorsement of any position by the Society.

CPLF 2020 – Fil orange. A23 – Prédiction du risque de maladies respiratoires

Tom Malterre is a well-known nutrition expert and a certified functional medicine practitioner. Not only did Tom write a pivotal book on the elimination diet, but he also lectures frequently on environmental toxins, coaches groups of clinicians in functional medicine, and educates patients in his own clinical practice. In today’s episode, Tom Malterre touches on several topics including the elimination diet, the metabolic effects of environmental toxins, and using food to assist detoxification and optimize health.   Today on The Lab Report: 2:40 Meet Tom Malterre and hear about his path to functional medicine 7:20 Clinical pearls for using the elimination diet 12:35 Environmental toxic exposures and metabolic effects 17:55 Toxic foods 21:44 Promoting detoxification 24:10 Talking to patients about minimizing toxic exposures 27:45 The Fireball   Additional Resources: Tom's Website The Whole Life Nutrition Cookbook The Elimination Diet Nourishing Meals Cookbook Broccoli-the DNA whisperer TEDx   Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: podcast@gdx.net. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.   See omnystudio.com/listener for privacy information.

Podcast Editor, Liz McInnes, interviews author Brad Bolon to discuss the article, "The Exposome in Toxicologic Pathology" which can currently be found in OnlineFirst of Toxicologic Pathology. Click here to read the article

Personalised Medicine is a priority of governments and research institutes around the world. This podcast episode introduces the topic. Tomorrow we dive a little deeper...

Talk to a Dr. Berg Keto Consultant today and get the help you need on your journey (free consultation). Call 1-540-299-1557 with your questions about Keto, Intermittent Fasting or the use of Dr. Berg products. Consultants are available Monday through Friday from 8:30 am to 9 pm EST. Saturday & Sunday 9 am to 5 pm EST. USA Only. Join my FREE 30-Day Low-Carb, No-Cheat Challenge Here! http://bit.ly/30-DayKetoChallenge Take the Free Keto Mini-Course: https://bit.ly/2Cpb03l Download Keto Essentials https://m.me/drericberg?ref=w2128577 Take Dr. Berg's Advanced Evaluation Quiz: http://bit.ly/EvalQuiz Epigenetics: https://www.youtube.com/watch?v=g12kI... In this podcast, we're going to talk about genetics. How much of your disease is genetic, and how much of your health is genetic? Are diseases genetic? People often think they simply have "bad genes." But, that's not true. Only 5-10% of disease is caused by a genetic defect that has been passed on by your parents. Most gene mutations are not inherited; they're somatic mutations. Somatic mutations mean it's not inherited, but caused by your environment. Epigenetics means above genetics. For example, think of DNA as a DVD and epigenetic as the DVD player. You can select what you want to activate and control. 90-95% of your health, and whether you get a disease is epigenetics. Exposome is the accumulation of all the exposures of an individual in a lifetime and how those exposures relate to health. We're talking about the exposure to your environment, which started when you were still in the womb. Everything adds up and can trigger certain genes, which leads to certain diseases. Dr. Eric Berg DC Bio: Dr. Berg, 51 years of age is a chiropractor who specializes in weight loss through nutritional & natural methods. His private practice is located in Alexandria, Virginia. His clients include senior officials in the U.S. government & the Justice Department, ambassadors, medical doctors, high-level executives of prominent corporations, scientists, engineers, professors, and other clients from all walks of life. He is the author of The 7 Principles of Fat Burning. FACEBOOK: fb.me/DrEricBerg?utm_source=Podcast TWITTER: http://twitter.com/DrBergDC?utm_source=Podcast YOUTUBE: http://www.youtube.com/user/drericberg123?utm_source=Podcast DR. BERG'S SHOP: https://shop.drberg.com/?utm_source=Podcast MESSENGER: https://www.messenger.com/t/drericberg?utm_source=Podcast DR. BERG'S VIDEO BLOG: https://www.drberg.com/blog?utm_source=Podcast

Local Hive Report, South Africa Beekeeping, Housekeeping, Australia-Puerto Rico, Exposome, The Pollinators Film, Tattoo Mocking, Spring meeting plan

Control Your Brain and Balance your Frequency in 4 Key Steps Hi beautiful! Chances are, you’ve never “thought” about the frequency of your brain and vibes of your thoughts. I’ve found through research and as a passionate hypnotherapist, the different states of mind we experience are quite important to understand how and why we practice exercises like meditation or self hypnosis to feel better and live more consciously. We’ve all experienced that magical feeling of being hit with ‘a ah-ha’ vibe. That moment of newfound clarity, a shift in perspective, and/or we just “feel” a certain way as we float through our day. Anyone can ‘train’ their body and brain to access different energetic states—it just takes some dedicated and repeated practice. The outcome? Feeling in the “ right kind of control,” a higher emotional intelligence, living outside of our monkey brain (ego) - and helping others do the same. ENJOY THE VIBE of this MIND SHIFTING PODCAST as I explain the 4 main brain wave frequencies and how to use them to your advantage. Turn up the sound-waves! THE BASICS OF BRAIN WAVES Brain waves are generated by the building blocks of your brain -- the individual cells called neurons. Neurons communicate with each other by electrical changes.We can actually see these electrical changes in the form of brain waves as shown in an EEG. Brain waves are measured in cycles per second (Hertz; Hz is the short form). We also talk about the "frequency" of brain wave activity. The lower the number of Hz, the slower the brain activity or the slower the frequency of the activity. You’ll see the popularity of “Binaural Beats” of different Hertz, and after you review the following information - you’ll better understand the right Hertz for your current time goals and accomplishments. Understanding the MIND. There are two main aspects of mind. The Conscious Mind This is the analytical and critical part of our brain that governs our awareness or consciousness at any point in time. It is the final processing point for our decisions, actions or reactions in daily life which we are aware that we are making. The Subconscious Mind This is the 'deeper' part of the mind that is responsible for processing thousands of things at any one time and for storing everything we have experienced in our lives in differing degrees of importance. It sort of runs on 'Auto Pilot' without us even realizing it is doing so much. In this respect it is much like the hard drive of a computer that stores information that is accessed by the other parts of the computer/mind. Have You Ever Wondered What Kind Of Brain Waves You Produce? First off, we don't ever produce only "one" brain wave type. Our overall brain activity is a mix of all the frequencies at the same time, some in greater quantities and strength than others. The meaning of all this? Balance is the key. We don't want to regularly produce too much or too little of any brainwave frequency. The systems that govern the brain are the most compact and complex on earth. Despite the fact that more has been learned about the brain in the last 30 years than in all of human history, science has not come close to understanding how all the pieces fit together to create human consciousness. However we do know this: Consciousness is related to communication between the different parts of the brain. Different levels of consciousness and states of mind are the result of the different areas of the brain communicating with one another at any given time. We also know that the different areas of the brain communicate by sending electrical signals along neurons that connect one area to another. There are more than 100 billion neurons in the brain, each making from hundreds to hundreds of thousand connections which means a total of a hundred trillion connections. These electrical connections are at the heart of how well the brain functions. How Do We Achieve That Balance? We need both flexibility and resilience for optimal functioning. Flexibility generally means being able to shift ideas or activities when we need to or when something is just not working. Well, it means the same thing when we talk about the brain. We need to be able to shift our brain activity to match what we are doing. At work, we need to stay focused and attentive and those beta waves are a Good Thing. But when we get home and want to relax, we want to be able to produce less beta and alpha activity. To get to sleep, we want to be able to slow down even more. So, we run into illness and trouble when we can't shift to match the demands of our lives. We're also in trouble when we get stuck in a certain pattern. For example, after injury of some kind to the brain (and that could be physical or emotional), the brain tries to stabilize itself and it purposely slows down. Flexibility is a key goal for efficient brain functioning. Resilience generally means stability - being able to bounce back from negative events and to "bend with the wind, not break". Studies show that people who are resilient are healthier and happier than those who are not. So it comes down to - how can we become more resilient? The brain needs to be able to "bounce back" from all the unhealthy things we do to it (drinking, smoking, missing sleep, banging it, etc.) And the resilience we all need to stay healthy and happy starts in the brain. Resilience is critical for your brain to be and stay effective. When something goes wrong, likely it is because our brain is lacking either flexibility or resilience. How Flexible are you? We want our brain to be both flexible - able to adjust to whatever we are wanting to do - and resilient - able to go with the flow. To do this, it needs access to a variety of different brain states. These states are produced by different patterns and types of brain wave frequencies. The 4 Operating Frequencies of the Mind These different states are classified according to the speed of the predominant brainwave signals from one neurological point to another at any one point in time. 1. Beta: This is where our mind usually operates in daily life. In such a state we have full conscious awareness and attention of everything around us and usually only one side of brain is operating. Beta is usually typified by brainwave cycles of 15 to 40 Hz (cycles per second) Higher cycles of Beta Frequency usually equate to stress, anxiety and 'over thinking' as the conscious mind becomes misguided or reacts negatively to a given situation. High brainwave beta frequency also equates to hypertension, increased heart rate, increased blood flow, cortisone production and glucose consumption. Generally speaking, you do not want to experience the high beta state too often if you are concerned about your health. 2. Alpha: A mild daydream or light relaxation state. Operating in Alpha can be exemplified to when you are driving a car and just cruising around or when you get captivated into a good book and sort of lose track of what is happening around you. Meditation is usually aimed at achieving Alpha and the brain operates in cycles between 9Hz & 14Hz. Alpha is typified by partial conscious awareness and partial subconscious predominance at the same time. It is useful to absorb information when in Alpha and is considered to be highly desirable for more effective studying. Alpha promotes more of the left side of the brain to be used for processing. 3. Theta: Deep relaxation where the conscious mind is, for the most part, 'switched off', and the subconscious mind is left to flourish. This is usually typified by sleep, dreaming, very deep relaxation and is where most hypnotists aim at taking their clients down to. Theta shows brainwave cycles operating at 5hz to 8hz. Theta is where ideas, visualizations and suggestion are more likely to enter the subconscious mind and consciously we become less aware of what is going on around us. 4. Delta: Extremely deep relaxation/sleep with complete subconscious operation. Delta is experienced in the deepest of sleeps and is interesting because it is proven that the physical body begins to recuperate and recover at a heightened level. You can be in waking delta if you are in an advanced state of meditation. This state is associated with 'kundalini' experiences. Delta is typified by slow brain waves at 1Hz - 4Hz. What Stops Our Brain From Being In Balance All The Time? Here Are The Big 6: Injury Medications, including alcohol Fatigue Emotional distress Pain Stress These 6 states tend to create a pattern in our brain's activity that is hard to shift. So how can we optimize these 4 states of frequency through our life for optimizing our vision, to create goals and then live consciously so we can a higher frequency and state of joy? Turn up and optimize your binaural beats. Delta waves (below 4 hz) occur during sleep Theta waves (4-7 hz) are associated with sleep, deep relaxation (like hypnotic relaxation), and visualization Alpha waves (8-13 hz) occur when we are relaxed and calm Beta waves (13-38 hz) occur when we are actively thinking, problem-solving, etc. The decision is yours, use your energy - wisely dear soul. In the minds (spirit) eye. May the force be with you. Light and Love - Kassandra Share the Love: If you like The Awakened Beauty Podcast…. Subscribe, Rate & Review via iTunes Visit us at awakenedbeautyhq.com for updates. Businesses: www.evoqbeauty.com | www.beautyecology.com Instagram @awakenbeautyhq Instagram @evoqbeauty Watch on Youtube at my channel: Awaken Beauty Podcast Shop natural health and beauty products with EVOQ Here’s how! Go to awakenbeauty-hq on ITunes and write your biggest takeaway in the rate and review section. Just pretend it says “ah ha” here!! Don’t just review the episode, I would love your ah-ha moment from this episode that is more specific so you can confirm your takeaway as you write, but also help others capture your brilliance. It’ll take 3 minutes from your day. What you declare will be life to others. So remember, go to I tunes to rate and review. Comment or question you’d like to ask Kassandra. P.S! Your review is not only paramount in helping others discover the show, but we also read each and every submission personally…and they mean the world to us. Love and Light! - Kassandra In the Meantime, STAY IN THE CONVERSATION! @awakenbeautyhq | #awakenbeauty Additional Support and Proof! Listen and learn to this video more from leading PHD's from the 12th Annual SSEW Symposium, “The Exposome & Metabolic Health.” Speakers discussed the role of social relationships, chemicals found in everyday items like beauty and hair care products, and our food environments in encouraging negative health outcomes such as obesity and diabetes, breast cancer, and even Alzheimer’s. Listen Here

If the subconscious mind is responsible for 95% of our decisions and behavior - how can we listen to start to change our lives, more consciously? This episode will share the fundamentals of linguistic “why, what and how.” I'm beyond excited to welcome you to join and align frequencies and empowering energy with Dani Katz - the queen of quantum language. While I do not remember exactly where I first encountered Dani’s FABULOUS BOOK (Word Up: Little Languaging Hacks for Big Change), it made a profound impact on my life and the circle around me. While I jam out to Patti Smith, an inspiration to Dani, I jive to the high vibe frequency of our episode and the profound power that each of us women individually behold to live and enjoy and share with others - that only reciprocates itself into a self-generated life-giving frequency that expands beyond ourselves and into this infinite ecosystem. Dani Katz is a word and change maker, an LA-based writer, artist and Quantum Languaging coach/consultant and author of The New P. Handbook, Vol. 1: Little Languaging Hacks for Big Change. She is on a mission to shift the paradigm with the power of our words. Starting with Dani’s story of waking up in the middle of the night with spontaneous paralyzation that led her way out through the power of languaging and words. See the pattern? Joe Dispenza had this same profound experience back to health. The truth is weaved through many (including my own experience) as we tap into the subconscious minds and how it creates our reality. So listen in - and grab your pen, as we upgrade our beliefs, and what it takes to shift our life experience as embodied beings on Earth. Whether you feel depressed, stuck or in a pattern, this is especially for you to listen to bring light to what comes up for you and start right away in the small shifts of how your self-talk and language patterns can shift your life-eternally. About Dani Katz: Dani established her reputation as one of LA’s edgiest literary talents by way of her bold voice, and her expanded perspective and her mastery of language. Dani’s practical experience and formal studies, including a master’s degree in journalism, Dani has spent the past several years immersed in the study of quantum languaging and conscious communication, researching and perfecting the ways, whys, and hows that language influences our every human experience. She is the author of Word Up: Little Languaging Hacks for Big Change and a quantum languaging consultant in her hometown of Los Angeles. What You’ll Awaken to: What awakened Dani and inspired her to create a value system to share with the world What is Quantum Languaging? How Dani woke up in the middle of the night with paralyzation out of nowhere and creating a new reality after reading: Hidden Language Codes by R Neville Johnston The nuances of how we can empower or dis-empower ourselves and world around us. If the subconscious mind is responsible for 95% of our decisions and behavior - how can we listen to start to change our lives, more consciously? How systems and language separates us and perpetuates oligarchy. Hierarchy versus Heterarchy How “feminism” is really the antithesis of what women “want” and how it separates How language is a fundamental building block of our entire known reality How sneaky being a “victim” can creep into our lives. How can we create atrophy to words not serving us The vibrational frequency of words Words are encoded with metadata and each word vibrates with unique frequencies that affects us on all levels How the Universe takes our beliefs and patterns as directions and directives When we use the word “should” - it actually puts someone “I know more than you/I have authority over you” is steeped in hierarchy, which is a paradigm we are moving away from and into a new paradigm of unity, inclusivity, peace, and abundance The most damaging words in our language and which words to use instead The power of words in self-talk A new take on the word “Anti” and my thoughts on Anti-aging. What it literally looks like to take quantum languaging into a corporation and how it moves a whole organization. A recent relationship breakup - and what Dani awakened to (all women must listen to this insightful life giving reflection). Exciting new fronts Dani is moving into and how to stay up-to-date on her journey and mission! HERE’S an EXAMPLE OF SOME WORDS TO SHIFT TAKEN FROM DANI’S BOOK: CAN: Will, Am going to, Am committed to, Am BUT: Still, Yet, Also , While WANT: Choose , Invite, Love, Welcome NEVER: Havent Yet, Haven’t Historically, Am excited to ALWAYS: Often, Am prone to , Have a tendency to Resources: Dani's Website Instagram @something.dani Share the Love: If you like The Awakened Beauty Podcast… Subscribe, Rate & Review via iTunes Visit us at awakenedbeautyhq.com for updates. Businesses: www.evoqbeauty.com | www.beautyecology.com Instagram @awakenbeautyhq Instagram @evoqbeauty Watch on Youtube at my channel: Awaken Beauty Podcast Shop natural health and beauty products with EVOQ Here’s how! Go to awakenbeauty-hq on ITunes and write your biggest takeaway in the rate and review section. Just pretend it says “ah ha” here!! Don’t just review the episode, I would love your ah-ha moment from this episode that is more specific so you can confirm your takeaway as you write, but also help others capture your brilliance. It’ll take 3 minutes from your day. What you declare will be life to others. So remember, go to I tunes to rate and review. Comment or question you’d like to ask Kassandra. P.S! Your review is not only paramount in helping others discover the show, but we also read each and every submission personally…and they mean the world to us. Love and Light! - Kassandra In the Meantime, STAY IN THE CONVERSATION! @awakenbeautyhq | #awakenbeauty Additional Support and Proof! Listen and learn to this video more from leading PHD's from the 12th Annual SSEW Symposium, “The Exposome & Metabolic Health.” Speakers discussed the role of social relationships, chemicals found in everyday items like beauty and hair care products, and our food environments in encouraging negative health outcomes such as obesity and diabetes, breast cancer, and even Alzheimer’s. Listen Here

Have you ever wondered WHY certain skincare products work better than others? Or, what makes “this” vitamin C, different from the other on the shelf? As unapologetic truth teller, natural beauty advocate and co-formulator of Evoq Beauty, I’m well aware of the surface information and tactics for selling natural beauty. First things first, I always look at the whole of a formulation and then work backward on getting to the endpoint safely and efficiently in the results I wish to achieve for the modern gal’s skin health needs. Just like you - I get pulled into all the allure of new fancy ingredients in the skincare scheme, and sometimes it’s sooooo convincing, between the attractive imagery and emotional words - I think “it must be true?” A little more digging, a phone call with my lab - I can quickly differentiate fact from fiction. So today, I’m here to help set the record straight. Like a festering, ready to get out pesky pimple, let’s BUST the common myths now. *Sorry for the gross visual, but - maybe that will imprint the BS I’m about to help ya pop! 1. “What you apply topically is up to 60% absorbed.” Let me start with SIZE MATTERS (get your mind out of the gutter). Skin lotion and potions are made with all different weights and shapes. As a lover of truth and natural health, the truth is - the natural skincare industry has been pushing this quote of “over 60% of what you put on your skin is absorbed.” Sorry, but it is not entirely true. Let’s get-go deep- really: The skin is made of many layers, three in which a formulator focuses on. The first layer that we see on top of the skin is called the epidermis. The second is called the dermis (where collagen and your natural hyaluronic acid gets produced) The third layer is the subcutaneous tissue (or hypodermis). My awareness on delivery systems excited me - and puzzled me as I started to first learn about nanometers, daltons and a bunch of other critical needs in a formulation for an accurate delivery system - for serious results. I quickly learned and am here to tell you - it’s a challenge for skincare products to penetrate beyond the epidermis layer. You can thank your bouncer (skin) for protecting you from potential harm such as stabilizing your skin barrier from losing hydration- as well as working to protect your skin from penetrating external toxic substances. Other key factors are how ingredients work together to strategically drive into the epidermis and slightly beyond, and free of chemicals. Evoq products are composed of skin-identical ingredients such as nano organic phytocannabinoids (CBD), liposomal Vitamin C and medical-grade liquid oxygen - all scientifically prove to drive deeper for visible radiance. The conclusion. It’s VERY hard for most skin care products to actually get past the skin barrier, which is why the delivery system of products and their ingredients is just as important, if not more important than the ingredients themselves when considering efficacy. For example, our pores are approximately 50 nanometers in size. So we developed our topcial nano Cell Regenerative CBD OIL molecular weight and size at approx 20 nanometers - driving further to get to skin-glowing work. Here’s an interesting video on skin and absorption. https://youtu.be/LKiZtYffteE 2. Really? “Dermatologist tested, Non-Comedogenic, & Hypoallergenic.” In order to make these claims, companies bring a collective group together and have them use the product. However, many have it done independently and the current state of a woman with normal skin doesn’t give a in-depth valuable data set. The product may have been non-comedogenic and hypoallergenic for those individuals with really great skin and no allergies, but that doesn’t mean it would be for the greater population. The conclusion: Just because the dermatologists who “tested” the products, doesn’t mean they liked them. Yes, it’s stating that the dermatologists tested it, not that they found the product effective. I suggest being aware of each ingredient and personally trial the product on your own skin. 3. “Occlusives suffocate your skin - for bad.” This is nuanced. Occlusives have different origins. Some synthetic and others are natural. Occlusives help lock in moisture by preventing skin water loss. When you apply a very heavy-duty moisturizer, your skin still feels pretty comfortable, right? The proceed with caution is when low grade synthetic or even natural fats tend to be used. How do you know? Trial and error. Look for cold pressed oils and organic creams. Used in mall percentages, even silicones ( derived from rock) can feel great and not clog. The conclusion: Many people think that silicones are suffocating and that they clog your pores. On the contrary, silicones are one of the most breathable occlusives out there! 4. “Argan to Argan,” go for the cheaper one! Oh, my. Just because the ingredients are the same, doesn’t mean it’s the same quality of product. Sorry for the sugar crave, let’s take oatmeal chocolate chip cookies, for example. Let’s say two people use exactly the same ingredients but one uses organic materials and raw cocoa chips in the cookies and the other uses store bought premixed batter. The store baked batch burns and deploys the pan with grease while the natural healthy batter turns out perfectly delicious. This works very similarly with skincare. Hungry? Wink The conclusion: Ingredients aren’t everything, the quality and the complete formulating methodology is what makes all the difference! 5. “Apple Cider Vinegar is a cheap one trick wonder toner for clearing up acne. “ Again this one is another cautious nuance to clarify for you. ACV has a superior exfoliating property and a very potent antibacterial property, so it does have potential in helping acne. The user beware is frequency of use. I wouldn’t recommend that you use this daily since the overuse of antibacterial products can diminish or eliminate good bacteria life balancing biome that is the main protector of your skin. The conclusion: If you want to start using ACV on your skin, only use it once a week and I suggest you always dilute it with water so that the pH is more skin-friendly. 6. Using “Clarisonic” type cleansing tools or foaming cleansers are the only way to get your skin clean. This may be one of the most skin damaging advice you could follow. Surfactants do eliminate makeup, dirt, and grime from your skin when you wash your face. But surfactants can’t differentiate dirt with your natural moisture and oils, which means it can take away what’s needed for barrier repair, especially if you cleanse too often. Skin barrier disorders tend to cleanse obsessively, but doing this is likely causing more harm than good. Instead of over-cleansing, look for gentle, non-stripping pH-balanced cleansers that won’t strip the good stuff. The conclusion: Don’t cleanse more than twice a day! I personally only rinse water on my face in the morning. It has not gotten dirty overnight and keeps your skin’s pH and biome in tact prior to applying moisturizer and make up. By skipping your morning cleanse might be just what your skin craves. 7. I’m of a darker nationality or darker skin type so I don’t need to apply sunscreen. Dark skin tones thinking that they don’t have to wear sun UV protection are “false things appearing true.” This is a serious health prevention and even could save your life. I personally know because I lost my brother to skin cancer - he was 24! Everyone needs to wear sunscreen. If I told you that aging (wrinkles, lines, sun spots, etc) is 90% from previous sun damage, would that persuade you? Here are some things you should know: There are two specific UV rays that you want to protect your skin from. UVB ray burns your skin and UVA ray ages your skin. The UVA rays are why every skin color needs to have a safe barrier. UVA exists in rainy and cloudy weather, not just when the sun is out. A broad spectrum sunscreen also helps what we now know damages even more deeply - IR (infrared rays) that emit off of our digital devices. This is one of those cases where “better safe, than sorry” cannot be truer. The conclusion: Apply a broad-spectrum sunscreen every single day, no matter your skin tone, to protect yourself and your skin from UVA,UVB rays and now known IR rays. 8. “It’s best to start using anti-aging skincare early on” I suggest being in the mindset of preventative methods that women can be doing like moisturizing properly, wearing sunscreen daily, and not causing too much physical degradation to your skin. As we age after the age of 30, we want to look for more safe ways to help cellular turnover while extreme help on keeping the outer barrier strong and firm. Consider adding actives (like vitamin C) and peptides, then moving up to natural retinoids later on. The Conclusion: Love your skin! It’s smart and it knows how to take care of itself. Tired of the overwhelming choices of skin care lines? Simply want a trusted, powerfully potent skin care line? SHOP EVOQ CLEAN BEAUTY + WOMEN’S WELLNESS FORMULATING STRATEGY: FORCES OF NATURE IT’S NOT JUST A PHRASE. IT’S THE FOUNDATION TO YOUR BEAUTIFUL HEALTH. Each Evoq formula is brimming full of the “Forces of Nature,” which contains abundant amounts of fatty acids (anti-inflammatory), essential minerals, vitamins, antioxidants (cell renewal and health) and delivery system carriers (deep penetration). The result it natural, balanced, radiant skin by using the highest quality ingredients-natural, organic and sustainable- from across the world. Every product is made in small batches to maximize freshness and effectiveness without the use of chemicals, cheap fillers or toxic preservatives. SLAY CELLULAR FATIGUE - REPAIR & REJUVENATE YOUR SKIN Your skin’s collagen, elastin, and moisture barrier take a beating from everyday stressors. We stay up to date and engaged in new skin studies while exploring the power of skin solutions that target and optimize your skin's fundamental layers. By working with your skin, not against it for instant and long term skin radiance. SHOP EVOQ BEAUTY + CBD REMEDIES Share the Love: If you like The Awakened Beauty Podcast… Subscribe, Rate & Review via iTunes Visit us at awakenedbeautyhq.com for updates. Businesses: www.evoqbeauty.com | www.beautyecology.com Instagram @awakenbeautyhq Instagram @evoqbeauty Watch on Youtube at my channel: Awaken Beauty Podcast Shop natural health and beauty products with EVOQ Here’s how! Go to awakenbeauty-hq on ITunes and write your biggest takeaway in the rate and review section. Just pretend it says “ah ha” here!! Don’t just review the episode, I would love your ah-ha moment from this episode that is more specific so you can confirm your takeaway as you write, but also help others capture your brilliance. It’ll take 3 minutes from your day. What you declare will be life to others. So remember, go to I tunes to rate and review. Comment or question you’d like to ask Kassandra. P.S! Your review is not only paramount in helping others discover the show, but we also read each and every submission personally…and they mean the world to us. Love and Light! - Kassandra In the Meantime, STAY IN THE CONVERSATION! @awakenbeautyhq | #awakenbeauty Additional Support and Proof! Listen and learn to this video more from leading PHD's from the 12th Annual SSEW Symposium, “The Exposome & Metabolic Health.” Speakers discussed the role of social relationships, chemicals found in everyday items like beauty and hair care products, and our food environments in encouraging negative health outcomes such as obesity and diabetes, breast cancer, and even Alzheimer’s. Listen Here

In this bonus podcast, internationally recognized dermatologist and neuroscientist Erin Gilbert, MD, PhD, FAAD, explains how external and internal daily aggressors (called the exposome) affect your complexion, and what you can do to keep it healthy. (Hint: These factors cause 80% skin aging, so skincare matters! Mineral-rich French thermal water may be in order!). This special mini episode was produced in partnership with our friends and skincare experts at Vichy Laboratories. Visit vichyusa.com to learn more about the #1 anti-aging brand in European Pharmacies.For the episode recap and discount code: https://www.fatmascara.com/vichyFor more on Dr. Gilbert: https://www.vichyusa.com/discover-vichy/experience-vichy/meet-our-expertsFor more on the Exposome: https://www.vichyusa.com/discover-vichy/experience-vichy/vichy-exposomFor more on how our products are made: https://www.vichyusa.com/discover-vichy/experience-vichy/vichy-formulation-charterFor more info on the Mineralizing Water: https://www.vichyusa.com/discover-vichy/experience-vichy/mineralizingwater See acast.com/privacy for privacy and opt-out information.

Hormones can have a major effect on your hair growth and skin aging process. These “symptoms” readily tell a story of what is really going on beneath those layers. Do any of these symptoms sound familiar? Hair loss in clumps or strands, thinning eyebrows, dry skin, fine lines and wrinkles and acne. Contrary to popular belief, these symptoms are not from getting older. While aging causes a decline in hormones, environmental and dietary factors also have a hand in speeding up the aging process. While we can’t control our biological clock, what if we could get a handle on things we can control? It starts with our endocrine system and not as easy as mastering the latest detox or thyroid protocol. We know that hormones are the body’s chemical messengers -- and keeping them in balance and in the best communication with all parts of our body are fundamental for feeling great - BUT WHAT ABOUT THiER FUNDAMENTAL EFFECTS ON OUR HAIR AND SKIN? Today with Julie Tebben (check out our previous two episodes) we are going deep in commonly surfaced hair loss and aging skin tips found and followed from what we may read on the holy google algorithms or recent magazine snippet. After you hear today’s episode, you’ll walk away with insights that will clarify confusion, frustration and - frankly waisted money on one trick ponies when addressing hair loss and what the skin needs at its fundamental level. Here, you’ll awaken to better skin and fuller hair on hormonal nuances of everything in between. What you’ll awaken to: Three primary issues associated with skin and thinning hair abnormalities. Thyroid Imbalances that have nothing to do with the thyroid at all The shift in protein and hydration needs as women age The most important macro and micro nutrients to support thyroid function Estrogen Dominance and how it can result in acne, oily skin, and hair loss. Detoxification of estrogen and how it’s like the “I Love Lucy” episode of the Bon Bon’s on a conveyor belt. The insulin connection to PCOS The danger and nuances of a liver detox How the liver acts like Amazon fulfillment center biochemical processes Phase 1 and 2 detox pathways and how to optimize them. Menopause Effects on hair thinning, skin thinning, loss of muscle and skin tone, wrinkles The Most often related to gut health and subsequent hormonal issues Complex food sensitivities; intestinal barrier issues and upregulated immune system Gut-dysregulation and how it stops the healthy balance of hormone production The best natural alternative before stating drug based minoxidil and finasteride for hair loss and (Root Revival Hair Growth System) How exactly regenerative medicine within the Root Revival Hair Growth System formula is a multi-therapeutic approach helping optimize the growth phase, and slow down the fallout phase. A lack of good products isnt the issue - but rather how to choose the right products that work for you. How the secret to youthful skin and hair isn’t a secret - It’s a strategy with consistency - starting at the root. Resources: Julie's Website Facebook Full definition of functional medicine from the Institute of Functional Medicine Institute of Functional Medicine practitioner search Re-Find Health practitioner search Share the Love: If you like The Awakened Beauty Podcast…. Subscribe, Rate & Review via iTunes Visit us at awakenedbeautyhq.com for updates. Businesses: www.evoqbeauty.com | www.beautyecology.com Instagram @awakenbeautyhq Instagram @evoqbeauty Watch on Youtube at my channel: Awaken Beauty Podcast Shop natural health and beauty products with EVOQ Here’s how! Go to awakenbeauty-hq on ITunes and write your biggest takeaway in the rate and review section. Just pretend it says “ah ha” here!! Don’t just review the episode, I would love your ah-ha moment from this episode that is more specific so you can confirm your takeaway as you write, but also help others capture your brilliance. It’ll take 3 minutes from your day. What you declare will be life to others. So remember, go to I tunes to rate and review. Comment or question you’d like to ask Kassandra. P.S! Your review is not only paramount in helping others discover the show, but we also read each and every submission personally…and they mean the world to us. Love and Light! - Kassandra In the Meantime, STAY IN THE CONVERSATION! @awakenbeautyhq | #awakenbeauty Additional Support and Proof! Listen and learn to this video more from leading PHD's from the 12th Annual SSEW Symposium, “The Exposome & Metabolic Health.” Speakers discussed the role of social relationships, chemicals found in everyday items like beauty and hair care products, and our food environments in encouraging negative health outcomes such as obesity and diabetes, breast cancer, and even Alzheimer’s. Listen Here

Anti-aging is more than just what you put on your face. There is a whole list of factors that go into healthy, balanced skin, including genetics, overall health, pollutants and diet. In Fact: Epigenetic studies now show that approx 80 percent of our health is influenced by our lifestyle and environment, leaving only 20 percent (or less) to our genetic “genes.” When that 80 percent is broken or not working efficiently, we then manifest dis-ease and many times it is reflective on our outer skin. Many of our health issues as a society today are now being linked to a potentially endocannabinoid deficiency. Symptoms can manifest in anxiety, sleep issues to cancer. Bringing it back to lifestyle, the endocannabinoid system ( the largest regulatory system) is supported by a number of ways. Sleep, exercise, nutrition - but as of recent, healing can be addressed through phytocannabinoids from hemp and cannabis. So how about our skin? Today we’re focusing on how CBD (cannabinoids) is a potent antioxidant, and when used topically- it is an easy, low-commitment way to bring new life support into your daily skin health routine. Don’t worry, I help debunk the myths and give it to your straight so you can shop with confidence based on proven science and how it helps our neuroendocrine system. Enjoy, and make sure to use “Awaken Beauty” for 25% off your first Evoq CBD Order! Share the Love: BONUS *** Get the FULL SHOW NOTES *** in a full beautiful DOWNLOAD Take action & get the FREE PDF here! SKIN + CBD FAQ Still curious? Get all your questions answered here on a previous editorial on the Beauty Ecology blog here! If you like The Awakened Beauty Podcast…. Subscribe, Rate & Review via iTunes Visit us at awakenedbeautyhq.com for updates. Businesses: www.evoqbeauty.com | www.beautyecology.com Instagram @awakenbeautyhq Instagram @evoqbeauty Watch on Youtube at my channel: Awaken Beauty Podcast Shop natural health and beauty products with EVOQ Here’s how! Go to awakenbeauty-hq on ITunes and write your biggest takeaway in the rate and review section. Just pretend it says “ah ha” here!! Don’t just review the episode, I would love your ah-ha moment from this episode that is more specific so you can confirm your takeaway as you write, but also help others capture your brilliance. It’ll take 3 minutes from your day. What you declare will be life to others. So remember, go to I tunes to rate and review. Comment or question you’d like to ask Kassandra. P.S! Your review is not only paramount in helping others discover the show, but we also read each and every submission personally…and they mean the world to us. Love and Light! - Kassandra In the Meantime, STAY IN THE CONVERSATION! @awakenbeautyhq | #awakenbeauty Additional Support and Proof! Listen and learn to this video more from leading PHD's from the 12th Annual SSEW Symposium, “The Exposome & Metabolic Health.” Speakers discussed the role of social relationships, chemicals found in everyday items like beauty and hair care products, and our food environments in encouraging negative health outcomes such as obesity and diabetes, breast cancer, and even Alzheimer’s. Listen Here

Hi there! Excercise for ya! Please step back from what you’re currently doing right now, you may even want to close your eyes - now….. just IMAGINE: Imagine if you could live everyday in a sense of calm while having great energy. You’re able to fall to sleep effortlessly and wake up alert. Your skin is clear and your hair abundantly grows Lastly, you have a aweseome labido and can enjoy sex. This is what it feels like to have balanced hormones. But unfortunately women commonly are left feeling: Bloated Anxious Fatigued Infertile Irritable Depressed Stubborn Fat And with Hair loss Could it be excess or deficiency? Julie and I break open the hormonal cascade and the top tips to keep them in check to avoid the previously listed symptoms. Given hormones are your body’s chemical messengers, they work slowly, over time, and affect many different processes, including metabolism, sexual function, reproduction, mood and much more. Get the 101 on Hormones and their complex process and how to assure we have the building blocks to make them. Toxins containing chemicals that mimic these building blocks or that mimic the hormones (xenoestrogens) themselves are also problematic because the body can attempt to create hormones using the wrong building blocks. About Julie Julie is a certified nurse practitioner who specializes in the management of functional health and hormone imbalances in young women through women entering the menopausal transition and beyond. With a professional certification in women’s health, Julie is also a certified practitioner with the Institute of Functional Medicine. Her new clinic grew out of a desire to focus on helping women live their best and their healthiest. Julie intimately understands and empathizes with the plethora of women coming to her office being discouraged and being told that “everything looks normal, leading them to an never ending internet search to find alternative approaches. Hormones, Nutrition and the Microbiome A Man's Perspective On Hormones. Laughter heals! Here’s a joke to share with all the vagina’s you know! One day a man found an old genie lamp in his yard. After turning it over several times, a genie popped out of the lamp and landed in front of the man. “I’m an old genie,” the genie said, “so I’ll grant you only one wish.” The man thought for a while and said, “I’d like a bridge from my garage to the Bahamas.” “A bridge to the Bahamas!” the genie exclaimed, “I’m old! I can’t make a bridge to the Bahamas!” The man thought for a few more minutes and said, “Ok fine, I’d like to understand women.” The genie deliberated for a long time, floating around and muttering to himself. Finally, he walked up to the men and said, “Ok, you want this bridge to have 2 lanes or 4?” Show note guide bonus! The hormone hierarchy- adrenaline, cortisol, insulin, thyroid, and sex steroids. Cortisol- Meditation (unique to what works for each individual, not one right way to meditate, how to get started) Sleep and rest critical, how to optimize sleep when frequently interrupted Timing of meals, alcohol, caffeine Supplements to calm the brain, release GABA Insulin- Avoid the impulse to eat complex carbohydrates or sugar when energy is low Balance protein and fat with simple plant based carbohydrates Fast between dinner and breakfast Thyroid- Nutrients and factors that support production and conversion of thyroid hormones What factors increase reverse T3 and block thyroid hormones from getting into the tissues Sex Steroids- Detox to reduce estrogen metabolism Xenoestrogens Progesterone steal Issues surrounding heavy periods in peri-menopause (ablation, hysterectomy)- this leads into the next section The sex steroids patterns in mid-life, perimenopause, and menopause. Mid-life connections are more often related to PCOS types of issues, postpartum depression, cortisol or thyroid related menstrual irregularities affecting fertility. Perimenopause is the loss of progesterone and estrogen dominance that increases the frequency and flow of cycles; many women get ablations or hysterectomy which fixes the symptom, not the cause. Accelerates the timing of menopause. Menopause is a natural transition; can be a great time for women, but often cortisol affects production of sex steroids as adrenals take over for production of hormones in ovaries after menopause. And, cortisol always comes first! HRT or not? When is it needed? When symptoms affect your life. Estriol is great to use vaginally for dryness and pain with intercourse. Can be used long term. Beneficial for urinary tract health as well. Sleep, energy, mood, and vasomotor symptoms- can try to use natural methods, but if not working bioidentical hormones are a great option. The “marketing term” controversy regarding BHRT. Long term HRT often used for bone health, brain function, and CV risk reduction in some women. Stress & Adrenals The body shuts down the hormones healthy metabolism to keep the “running from the zebra” body’s perceived danger. Nearly every woman’s adrenals (hidden stress) steals from their thyroid and sex hormones. Women experience early menopause, infertility, hair loss, mood swings, lack of sex drive, and all the other “unexplainable symptoms”. So the question is - How to support your adrenals so all the other symptoms will vanish? Lifestyle factors that allows us all begin to heal now? Endocannabinoid Deficiency Syndrome: The female endocrine system is lined with CB2 receptors. This can be migranes, gut issues, PMS, to hot flashes. Look for our next podcast with Julie, where we’ll share how other core clinical imbalances affect hormones (gut, immune/inflammation, detox, energy, etc) If you missed our foundational first episode with Julie, you can find that interview back in Episode 6 where we spoke with Julie about The growth of Functional medicine The biological systems within the mind and body What the first comprehensive appointment looks like The real cost of healthcare, Insurance, HSA’s and how Julie’s fee structure works Share the Love: If you like The Awakened Beauty Podcast…. Subscribe, Rate & Review via iTunes Visit us at awakenedbeautyhq.com for updates. Businesses: www.evoqbeauty.com | www.beautyecology.com Instagram @awakenbeautyhq Instagram @evoqbeauty Watch on Youtube at my channel: Awaken Beauty Podcast Shop natural health and beauty products with EVOQ Here’s how! Go to awakenbeauty-hq on ITunes and write your biggest takeaway in the rate and review section. Just pretend it says “ah ha” here!! Don’t just review the episode, I would love your ah-ha moment from this episode that is more specific so you can confirm your takeaway as you write, but also help others capture your brilliance. It’ll take 3 minutes from your day. What you declare will be life to others. So remember, go to I tunes to rate and review. Comment or question you’d like to ask Kassandra. P.S! Your review is not only paramount in helping others discover the show, but we also read each and every submission personally…and they mean the world to us. Love and Light! - Kassandra In the Meantime, STAY IN THE CONVERSATION! @awakenbeautyhq | #awakenbeauty Additional Support and Proof! Listen and learn to this video more from leading PHD's from the 12th Annual SSEW Symposium, “The Exposome & Metabolic Health.” Speakers discussed the role of social relationships, chemicals found in everyday items like beauty and hair care products, and our food environments in encouraging negative health outcomes such as obesity and diabetes, breast cancer, and even Alzheimer’s. Listen Here