Podcasts about Autophagy

Dr. Deb Muth 00:00:09 Hi there, how are you? Bob Miller 00:00:10 Excellent! Pedaling as fast as humanly possible, but doing okay. Dr. Deb Muth 00:00:14 Good, good. Well, I’m looking forward to our conversation today. This should be amazing. Bob Miller 00:00:20 Yeah, it should be a lot of fun. Dr. Deb Muth 00:00:22 Yeah, anything that’s off-limits for you in, our conversation? Bob Miller 00:00:28 No. Dr. Deb Muth 00:00:29 Okay, anything you want me to make sure we cover for you? Bob Miller 00:00:33 Well, I mean, is it okay if we put a little plug-in for our software? Dr. Deb Muth 00:00:35 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:38 Hey, can we… can we do a screen share? Yes, we can. Yeah, because I want to show you some maps, and… Dr. Deb Muth 00:00:43 Okay. Things like that, yeah, so… Perfect. So just let me know when you want to do screen share. Bob Miller 00:00:48 Okay. Dr. Deb Muth 00:00:49 And yeah, feel free to plug your software wherever you want to. Bob Miller 00:00:53 Okay, well, good. Let me pull up a, a slide for that, and give me one second, I just want to shut the door to my office to get the noise down. Dr. Deb Muth 00:01:01 No worries. Bob Miller 00:01:16 And, how should I refer to you? Dr. Debb? Dr. Muth, what do you like? Dr. Deb Muth 00:01:18 Dr. Deb is great, or Deb, either way, I’m pretty informal, so… Bob Miller 00:01:22 Yeah, and… Bob is fine for me. Okay. Yeah. Yeah, there you go. Why people feel like they need this, son. Special name, it’s like, seriously. Dr. Deb Muth 00:01:33 Right? I agree. Bob Miller 00:01:35 When I work with my clients, it’s like, Dr. Millison, just, just bop, just, just bop. Dr. Deb Muth 00:01:41 Yep, that’s how I am, too. Just call me Deb, it’s good. Dr. Deb Muth 00:01:44 They feel a little awkward with that, you know? They’re not used to that, but… Bob Miller 00:01:48 Alright. And you’re a naturopath, medical doctor. Dr. Deb Muth 00:01:52 A nastropathic doctor and a nurse practitioner. Oh, nice. Yeah, so I got the best of both worlds, right? Bob Miller 00:01:58 Yeah, damn. Okay. Alright, so here we go… There we go. Alright, so I got that ready, and then I will do a, I will do a screen share. I think you’re gonna really, appreciate what we’ve come up with. We’ve come up with the concept of, Cellular CPR. Dr. Deb Muth 00:02:23 Oh, nice! Bob Miller 00:02:24 And that is, construct the cell membrane, Protect the cell membrane. And restore it if it’s damaged. Dr. Deb Muth 00:02:32 Love that. Bob Miller 00:02:34 I love that. Yeah, so that’s what we’re focusing on, and then how, You know, we want to get to the point that, you know, most people think of genetics, they think of, like, 23andMe or Ancestry. Dr. Deb Muth 00:02:44 Yeah. Bob Miller 00:02:45 And then you have the professional geneticists who are looking at, you know, odd things that could create a disease. We’re looking at functional genomics. Dr. Deb Muth 00:02:54 Which is so much better. Bob Miller 00:02:56 Yeah. Are you familiar with what we do here, or… Dr. Deb Muth 00:02:58 A little bit, a little bit. So, it’ll be new to me, too, so I’m excited. Bob Miller 00:03:03 And how much time do we have? Dr. Deb Muth 00:03:04 We have an hour, give or take a little bit on either side. Do you have a hard stop anywhere? Bob Miller 00:03:10 No, no, I put a, I moved my clients around, and I don’t have anybody till, 3.30, so we’re good. Okay. Dr. Deb Muth 00:03:16 Perfect. Alright. Bob Miller 00:03:18 It’s like we’re getting started early as well, so… Dr. Deb Muth 00:03:19 Yeah, we’re getting started a little bit early, so that’s good. Bob Miller 00:03:22 Yeah, I just got my office cleaned up, so… Dr. Deb Muth 00:03:23 Okay, good. All right, are you all set to get started? Bob Miller 00:03:28 I’m good to go, my friend. Dr. Deb Muth 00:03:29 I’m gonna just record a little intro and a little bit of a, hook for people, and then we’ll get started. I’ll ask you to kind of tell us a little bit about yourself, and then we’ll just take this conversation wherever it’s supposed to go. Bob Miller 00:03:39 Okay, you got it. Dr. Deb Muth 00:03:40 Alright, sounds good. So what if the reason you’re not healing isn’t your diet, your supplements, or your labs, but it’s actually your genes? Dr. Bob Miller is uncovering how genetic variants, when combined with modern toxins, explain why some of us stay sick no matter what we try. Today, we’re talking genetic pathways, detox blocks, and the new science every wellness warrior needs to know. Welcome back to Let’s Talk Wellness Now, the show where we uncover the root causes of chronic illness, exploring cutting-edge regenerative medicine, and empower you to heal from the inside out. I’m Dr. Deb, your medical detective, and today, our guest, Dr. Bob Miller, is a true pioneer in functional genomics. He’s a board-certified traditional naturopath and the founder of Neutrogenetic Research Institute. And he’s the leading groundbreaking research on how genetic variants influence chronic illness, inflammation, and detoxification. His work has been recognized on international stages, uncovering links between genetic expression and conditions like Lyme disease, mast cell activation, or MCAS, and mitochondrial dysfunction. I’m so excited to talk to Dr. Bob today. He is gonna reveal some things that even I don’t know about, so I’m excited to learn alongside of you guys. So… Dr. Bob, let’s get started. Tell us a little bit about yourself, and kind of how you got on this journey. Bob Miller 00:05:04 Well, that’s, that’s interesting. I was sort of like a mid-career coming to the natural health field, because in my early 30s, I found myself with a severe case of ulcerative colitis. Bob Miller 00:05:15 And I was in the hospital for 21 days. probably within hours of death, pleading to death. And they told me I’ve got one option, and that is cut out the colon and wear a bag. Didn’t sound like a lot of fun. Dr. Deb Muth 00:05:27 Not an option I would want. Bob Miller 00:05:29 So, you know, the medical folks wasn’t real happy with me, but I said, yeah, I’d like to explore some alternative things.Never thinking that I’d get into this field, and then I just, you know, worked with some herbalists and things that I found absolutely fascinating. So, that’s how I got into this around 30 years ago. And, haven’t looked back since, and just having a… having a blast as we now move into how our genetics impacts things. So, that’s what we’re gonna… that’s what we’re gonna talk about today. Dr. Deb Muth 00:05:58 I’m excited to talk about this genetic thing. When you started over 30 years ago, what kind of patience and problems first inspired you to dig deeper into that root cause healing and kind of get into the genetic piece of it? Bob Miller 00:06:10 Sure. Well, you know, as a… now, I’m in a part of the country called Lancaster County, Pennsylvania, where there’s a lot of Amish and Mennonite, and they gravitate towards these things.So, this is their first thing to do, and that doesn’t work, then they’ll go other routes. So, you know, back then, we just saw typical, you know, a little tired, constipation. You know, a little bit of fatigue, arthritis, those kind of things. But things have changed dramatically over the years, as people are now getting more chronically sick. You know, it’s worse than it’s ever been. And what we’re finding is the, the culprits Primarily is mold exposure and Lyme disease. When people get those two together, they’re just… it’s an inflammatory cascade that nobody can seem to unravel. So that’s where we spend a lot of our time. And we’re also spending a lot of time looking at mental health, like ADD, ADHD. And, we give… this year I’ll be speaking at three autism conferences. And we can dig into that a little bit as to why we think we’re seeing such a dramatic increase. And aside from autism, that used to be 1 out of 1,000, now it’s 1 out of 33, or 23. You know, we’re also seeing dramatic increases in ADD, ADHD. People are stressed out. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. Dr. Deb Muth 00:07:37 This should be a fun visit. We can cover lots of topics. I am so excited. So, you founded Nutri Genetic Research Institute in 2015. What did you hope to accomplish, and what kind of surprised you in your findings so far about that? Bob Miller 00:07:51 Well, you know, let’s back up at what, you know, genetics is used for. Everybody’s familiar with 23andMe and Ancestry that, you know, tells you where your ancestors came from. Then you have your professional geneticists. I mean, these are people with a degree in genetics. And they’ll look for, you know, very odd sort of things that are prone to relate to a disease. So there are disease-related genetics. Well, in functional, we don’t look at either of those. We look at For example, how you’re breaking down your fats and utilizing them. How you’re recycling your glutathione. How you might be handling your iron. And none of those are disease-causing on their own.And none of those are disease-causing on their own. But when they pile up on you, and then combine that with environmental factors, that’s when things start to go south on us. So, that’s what we’re doing, we’re looking at patterns. And our first foray into this was, we did studies on Lyme disease. And our first foray into this was, we did studies on Lyme disease. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. Others have a little more struggle, and then others are struggling terribly for years. So there’s an old adage of genetics loads the gun, environment pulls the trigger. Dr. Deb Muth 00:09:14 Yeah, that is so true, and I think when we’re talking about Lyme and mold and things like that, we forget sometimes that our genetics can predispose us to be more sensitive to those things, and if we have genetic pathways where we don’t clear things properly, it’s harder for us to get them out of the body. And then you add on that whole rain barrel effect that we’ve always used as a functional medicine term, right? If the barrel’s half full, you’re okay. If it’s full, and now it’s spilling over, it’s a bigger problem. Have you guys found, too, that some of these environmental things actually are changing the genetics of people, or how they’re processing their own genetics? Bob Miller 00:09:53 Well, let’s go back to, Genetics 101. But we’ll go back a little bit further. So, what an interesting mechanism, what a miracle the body is. Bob Miller 00:10:03 Fats, carbohydrates, proteins, drink water, breathe air, expose the sunlight, and somehow everything gets made. I mean, when you just step back and think about that, it’s like, It’s pretty darn amazing. Dr. Deb Muth 00:10:15 I always tell women, you know, the fact that we get pregnant and we have healthy pregnancies and births is a miracle, because if we had to try to control that, that wouldn’t work so well. Bob Miller 00:10:25 Right. Well, that’s another miracle. These microscopic sperm and egg, human being, 9 months later, it’s like. But even inside of us. We are making our hair, our skin, our nails, our blood vessels, our ATP, our energy, it’s all being created. Well, that gets created by enzymes. So, enzymes take one substance, combine it with something else, and make something new. Then another enzyme comes along and does the same thing. Your DNA is the instructions on how to make the enzymes. So, when we are conceived. If it’s a, if it’s a female, of course, it’s the XX, the two chromosomes. You know, we’ve… everybody’s seen those… the genetics that… Listed pair. So, if it’s a female, the father donated the X enzyme. And the mother has no choice but to give the eggs, so that’s female. If the father donates the Y, you have a male that’s in chromosome number 1. Then 2 through 23 is the rest of the instructions on how to make enzymes. So, what can happen? We can get what are called SNPs, single nucleotide polymorphisms. And SNPs just mean that the instructions to make the enzyme’s not quite as good. So, if one parent gives a SNP on the making of an enzyme, The enzyme’s fine. It works. But, general rule of thumb, It may only work at 70-80% of efficiency. Now, a good analogy is think of an 8-cylinder and a 6-cylinder car. If parents give you good information, that’s like having an 8-cylinder car. If one parent gives you that snip, it’s like having a 6-cylinder car. Now, is a 6-cylinder car a fine car? Sure. It’ll get you from point A to point B, but it’s just going to have the power of an 8-cylinder. Then if both parents give you a SNP on the same enzyme, it may be 30-40%, and that’s like having a 4-cylinder car. Sits in the driveway, looks the same, puts gas in it, everything. But if you’ve got a 4-cylinder car. Probably not a good idea to go cross-country pulling a trailer behind you up and down mountains. Dr. Deb Muth 00:12:29 This is true. Bob Miller 00:12:32 So… We can get an 8-cylinder, 6-cylinder, or 4-cylinder enzyme. Now, if it’s not under a lot of stress, if that 4-cylinder car is just taking you to the bank and the grocery store. It’s just as good as an 8-cylinder car. But if you gotta pull that trailer, and there’s a lot of stress on it, being mountains, it’s gonna struggle. Now, there’s one other little caveat to this, and that is some genetic mutations are gain-of-function. They actually work faster. Now, we have enzymes that do all kinds of things. We have enzymes that make and recycle our antioxidants, but we also have enzymes that make inflammation. No, that’s a good thing, because if we get a virus or bacteria, if you didn’t make inflammation to kill it, well, we’d all die of infection. So, you know, we tend to think of free radicals as bad, antioxidants as good. They both play an important role. But interestingly, some of the major enzymes that make inflammation, they can be overactive. They can be turbocharged. And when they’re stimulated by environmental toxins, they overreact. Bob Miller 00:13:40 And therein lies the problem. When they overreact, we have a problem. Bob Miller 00:13:46 So, if we have genes that overreact when stimulated. And then the enzymes that take care of inflammation are underactive. Then you’re gonna be more inflamed. You know, the majority of people that, you know, come for functional medicine Or naturopathic help, or… Inflammation that they can’t seem to get under control. Dr. Deb Muth 00:14:06 Right. Bob Miller 00:14:07 And we will be, you know, during this hour, we’re going to look at some of the pathways that make that happen. So, what we can do then, we can’t change our genetics. When you’re conceived, that’s the hand you’re dealt. When your life would be over, if someone would take some tissue and measure, it’d be exactly the same as conception. Does it change. Bob Miller 00:14:28 The enzyme’s ability to do its job may be compromised. Because remember I said there’s a, the enzyme takes a cofactor. So an enzyme takes substance A, cofactor, make substance B. Well, if that cofactor’s not there, the enzyme’s not going to work either. So, you could have an 8-cylinder car, and if there’s no gas in it, it’s not going anywhere. So… It’s the strength of the enzyme, it’s the cofactor to do the A to B conversion. And that’s what we’re going to get into. So, many people say, well, where did these SNPs come from? Nobody knows for sure. Sometimes they’re what’s just called de novo, when the sperm and egg go together, the instructions get mixed up a little bit. We do believe a lot of it came from a long time ago, when we were almost wiped out by sexually transmitted diseases. And those STDs were altering the genes when the conception, in other words, when the sperm went into the egg, the STDs were interfering. And causing the problem, so… I often joke, if you want to blame somebody. Blame your great-great-great-great-great-great-great-grandparents for, being a bit promiscuous, so… Dr. Deb Muth 00:15:31 Yeah, for being… having a little too much fun, right? Bob Miller 00:15:35 So, we don’t know for sure, but, you know, there are some that, But most of the SNPs that we get inherit from our parents. So, if you look at a child. And you look at the SNPs. 99.9% of the time, it came from one of the parents. Dr. Deb Muth 00:15:50 In identical twins, do they have the exact same identical makeup? Bob Miller 00:15:54 Yep, Dr. Deb Muth 00:15:56 But not in fraternal twins, correct? Bob Miller 00:15:59 No, no, those could be different, Jeff. Dr. Deb Muth 00:16:00 It could be different because they have different sacs, they’re not sharing that same genetic makeup. Bob Miller 00:16:04 Yeah, so keep in mind, both your mother and your father have, you know, the two And so you get one from one parent, one from another. Dr. Deb Muth 00:16:13 So… Bob Miller 00:16:14 Interesting situation. I had, 3, 3 boys. And, we were looking at an enzyme related to breaking down oxalates. Now, the mother and father each had one SNP, and that’s called heterozygous. Three boys, and they all come together, they’re Amish boys, they’re a lot of fun. And I looked at their genomes, and the one boy didn’t have any SNPs at all. And one had won. And the other one had two. Dr. Deb Muth 00:16:41 Interesting. Bob Miller 00:16:42 So, we don’t quite know how these things get handed off, but with the parents each having one, you could have a child with none, one, or two. So, the one, his ability to break down oxalates, which is fine. The other one was slightly impaired, and the other one was dramatically impaired. So, you can have 3 children, and it all depends what the parents have. Now, if a parent has a homozygous, or 2 copies. And the other parent has nothing. Every child will have one. Okay. If both parents are homozygous, that they both have two, Every child will have two. Dr. Deb Muth 00:17:19 too. Bob Miller 00:17:20 Yes, so that’s the way it works, but, you know, but it’s somewhat rare that both parents are homozygous on an enzyme, but it can happen. Dr. Deb Muth 00:17:27 Do we think that infections today, like Lyme disease or mold exposure, things like that, if the parent, the woman, primarily, I’m thinking, is pregnant, and she actively has these infections. Can those infections affect the genetics, kind of like a past sexual transmission did where we thought back in the day? Bob Miller 00:17:47 Yeah, I… I mean, I’m not that much of a geneticist to answer that for sure, but my thought would be no, that at conception, the pattern’s made. Dr. Deb Muth 00:17:55 Okay. And then that’s… that’s the hand you’re dealt. Bob Miller 00:17:58 Yeah. So, I tell people we have good news and bad news. The good news is we can compensate for the weakness. The bad news is we can compensate for the weakness. Dr. Deb Muth 00:18:09 That is so very true. Bob Miller 00:18:11 Yeah, we can’t, because I often get asked, so we’ll do some things now, and we’ll check my genes again, and they’ll be better. It’s like, nope. Dr. Deb Muth 00:18:18 Oh, – – Bob Miller 00:18:19 You gotta play the hands you’re dealt, so… Dr. Deb Muth 00:18:21 That’s right. Bob Miller 00:18:22 You can test your genetics… if you’re looking at the same enzyme, you can test it every year. It’s not gonna change. It’s like the blueprint. Dr. Deb Muth 00:18:30 It’s good and bad, right? It’s the one test you only have to do once in your lifetime. Bob Miller 00:18:34 No, unless, you know, like, our. Dr. Deb Muth 00:18:36 All the time. Bob Miller 00:18:37 Yeah, now our test looks at, called the Functional Genomic Analysis Test of your genomic Resource. We look at 220,000 steps. Dr. Deb Muth 00:18:46 Wow, that’s a lot. Bob Miller 00:18:47 That’s not all of them. Dr. Deb Muth 00:18:49 Right. Bob Miller 00:18:50 So, maybe in the next year, we’re gonna come out with our third version of the chip. And then, if someone wants to get those new things that weren’t on it, they’d have to repeat. But whatever we measured is gonna stay the same. Dr. Deb Muth 00:19:03 That’s a lot of SNPs to look at. Bob Miller 00:19:05 Keeps us busy. Dr. Deb Muth 00:19:06 But there’s still, but there’s still SNPs that we. Bob Miller 00:19:09 That we’d like to have that we don’t have, so… Bob Miller 00:19:11 We started out with version 1 on our genetic test, then we worked with version 2, and we’re already compiling a list of what version 3 would look like. So if somebody has our version 2, And we’re saying, you know what, it’d be nice if we could see these, well, then you’d repeat, but it won’t change what you already know, so… Dr. Deb Muth 00:19:29 Got it, got it. So, when you started out, and you started looking at the research of Lyme disease and chronic infections, which detox pathways are most important for people who struggle with those conditions? Bob Miller 00:19:43 Okay. You know what might make sense as we do a screen share, and I’ll actually show you the pathway. Does that make sense? Bob Miller 00:19:48 Alright, so… let’s see if I… let me just press the share… Dr. Deb Muth 00:19:52 Yep, you should just be able to press share. Bob Miller 00:19:54 And… number 2. Okay. Are we seeing the screen there? Bob Miller 00:20:01 Okay. Dr. Deb Muth 00:20:02 So, this is a map that we made. Bob Miller 00:20:05 And by the way, this is not… All-inclusive of all the things we look at, but we believe this is a core issue. So, where we’re going to start here, there’s something called the microglia. And the microglia are glial cells. They’re in the brain and the central nervous system. And they’re very interesting little creatures, because most of the time, and this is just a drawing of what they sort of look like. Most of the time, they’re in what’s called the M2 anti-inflammatory mood. What that means, these little guys pick up dirt, debris, Recycle them. Turns on an enzyme called interleukin-10 that’s anti-inflammatory. And just kind of does general housekeeping. And just kind of does general housekeeping. However, when a trigger comes along. However, when a trigger comes along. They… it’s the same glial cell, but it moves over to a very pro-inflammatory enzyme. A pro-inflammatory glial cell. And it triggers these 3 enzymes, Actually, these four. That are pro-inflammatory. Tumor necrosis vector alpha, Interleukin-6. NF Kappa B, Inos. Now, these create inflammation. So you might think, well, why is that good? Well, if you have some foreign invader, virus, bacteria coming in, parasite. If you didn’t have these guys coming to the rescue, you would just die of infection. So, these guys are your friend unless they’re your worst enemy. Because TNFA, and we’ll show you when we actually do a demo account, TNFA can be overactive. So, in other words, it over-responds. Interleukin-6 can be overactive. And if Kappa-B can be overactive. The INOS, and I’ll explain each of these as we go through a demo, can be overactive. Now, what that means is, you’re very good at killing virus and bacteria. But this is where autoimmune disease comes in, and just inflammatory conditions. Now, this is just speculation, but we think what happened is, as you know. Thousands of years ago, we didn’t have refrigeration, we didn’t have sewer, we didn’t have pure water, and we didn’t have antibiotics. So, if you made it to 40, you were an old-timer, because everybody was dying of infection. So, what we believe happened is, by what’s called natural selection, Having these overactive. A thousand years ago was to your advantage. Dr. Deb Muth 00:22:31 Hmm. Bob Miller 00:22:32 But now… We have pure water, we have refrigeration, we have sewers, we have antibiotics. But now we have environmental factors that are stimulating them. Now it’s to our disadvantage. And we’ll talk about that a little bit as it relates to the hemochromatosis genes and maybe the G6PD. Dr. Deb Muth 00:22:48 Yep. Bob Miller 00:22:49 Now, why are we becoming so inflamed? Let’s look at the triggers. Now, one of my, favorite expressions is. I was born all the way back in 1954. Dr. Deb Muth 00:23:01 And it was a different world back then. Bob Miller 00:23:05 These are some of the triggers. And we’ll get into these, but right now, high fructose corn syrup, And the high-fat diet. High fructose corn syrup only came about in 1968. So now we’re being exposed to high fructose corn syrup. Then… we didn’t have these, these viruses like COVID. Dr. Deb Muth 00:23:26 Yeah. Bob Miller 00:23:27 Now, there’s now pretty strong evidence that COVID Was actually, you know, made as a gain of function. It’s debated, and I’m not taking an opinion on it, but there’s some people who believe Lyme disease was also a part of experimentation. Dr. Deb Muth 00:23:40 Go. Bob Miller 00:23:41 Then we have molds, and it appears as though mold is getting stronger. you know, 20 years ago, when I was seeing folks, mold wasn’t on the radar. I would say 7 out of the 10 folks we speak to today have mold problems. Yeah, 20 years ago, we talked more about mold allergy being an issue versus mold toxicity being an issue. Right. So… I know some folks are, you know, speculating what’s happening, but one of the theories out there is that EMF is strengthening mold. I don’t know if you ever heard that theory, and I don’t… Dr. Deb Muth 00:24:13 I have. Bob Miller 00:24:14 I’m not claiming it’s true, but it’s an interesting theory. Then even, you know, your black mold from water-damaged buildings. Then our air pollution is getting worse. We’re getting more toxic metals. Dr. Deb Muth 00:24:26 You know, if we have a… Bob Miller 00:24:27 You know, we’re gonna look back someday and say, what were we thinking, smearing aluminum into our armpits? The, what were we doing putting mercury in our teeth? Then, you know, glyphosate. When I was a kid, there was no glyphosate. So, all of these herbicides and pesticides. Polychlorinated biphenols, And then EMF. So, we love our cell phones, you know, and I think unless you, or in the middle of the desert, or down in a cave, you’re being exposed to EMF somewhere. So, you know, we have our cell phones with us, we have, We have Wi-Fi, the towers are everywhere. And we don’t know long-term, but we may find that this can… this creates some inflammation. And I don’t know if you get any folks, but do you have any folks that have… are they EMF sensitive? Dr. Deb Muth 00:25:16 Oh yeah, we have a whole bunch of them. Bob Miller 00:25:18 Yeah, and then if you have any TBIs, So, plenty of things here. that will stimulate into the microglia, M1. Now, you could say, well. We’re all pretty much exposed to the same thing. Why do some people get hit harder than others? So here’s where we’re gonna start. There’s an enzyme called Nrf2 and RF2. And Nrf2 is the enzyme that senses when there’s inflammation. And turns on hundreds of anti-inflammatory enzymes. We’ll show when we do the demo, you can have genetic weakness on NERF2. And NERF2 inhibits and slows down microglia M1. supports M2. Now, if it’s not complicated enough, there’s an enzyme called KEEP1. And KEEP1 inhibits NRF2. And you can actually have gain of function on keep 1, that makes Keap 1 stronger. So… A lot of the people who land on my doorstep So… A lot of the people who land on my doorstep Both parents gave a mutation on KEEP1, making it overactive. Both parents gave a mutation on KEEP1, making it overactive. Dr. Deb Muth 00:26:31 Hmm. Dr. Deb Muth 00:26:31 Hmm. Bob Miller 00:26:32 Suppressing Nrf2, nerve 2 might be weak. So, nobody’s putting the brakes on, M1. And by the same token, Nerve 2 supports M2. Then there’s a process called mTOR and autophagy. mTOR stands for mammalian tard of rapamycin, the growth of new cells. And then autophagy, taking our dead cells and recycling them. We need a balance between the two of them. If we didn’t have mTOR, the sperm and the egg would never become the baby, the baby would never become the adult, we wouldn’t make new cells. But our cells are constantly, you know, the old cells dying off. Autophagy is where we take that debris from the cell and recycle it, just like a farmer Plows the crop under at the end of the year. The dead plant then becomes the fuel for the spring, your dead cell becomes the fuel for the spring, and that’s autophagy. So we’re gonna look back someday and say, what were we thinking? We give our animals growth hormones so they get fatter faster. Oh my. So, we consume those animals, and inventory runs faster. Now, for anybody who’s, You know, maybe above 40, 45 years old. Think back when you were 12, and what did girls look like? They were primarily flat-chested little girls. Now they look like 16-year-olds. Because environmentally, we’re jacking up mTOR. So, mTOR stimulates microglia M1, suppresses microglia M2. Probably 80% of the folks we visit with. This is the part of the problem. NRF2 is weak. mTOR is strong. Environmental factors come along. And this guy gets carried away. He doesn’t do that burst and move back. Stays here. We’re calling that How environmental factors create a locked-in, pro-inflammatory. and neurotoxic phenotype. In other words, once it starts, it just keeps… Feeding upon itself. Alright, so what happens now when microglia is overactive. it triggers these 3 enzymes, TNFA, N of kappa B, And interleukin-6. Each one of these can have genetics that make them run stronger. Then it stimulates an enzyme called NLRP3, Which makes what are called inflammasomes. Now, guess what inflammasomes can be? Your best friend or your worst enemy? Because they will, if you’ve got, again, a virus or bacteria, or possibly even some bad cells in the body. They will zap them. Well, that’s good. Unless it’s overactive. Unless it’s overactive. And then what it does, through interleukin-1 beta, makes excess glutamate. And then what it does, through interleukin-1 beta, makes excess glutamate. Anxiety, gut inflammation, OCD, ADD, autism. And, you know, glutamate, we’ll talk about that a little bit, but glutamate makes you intelligent, highly motivated go-getter. but can also be excitatory. And then, look what it does. Let’s see, do I have the drawing tool here? Yes, I do. Okay. So, it comes down through here, Makes the glutamate. Comes back up through here. through the ADORA 2A enzyme, Then we’ve got a feedback loop that feeds upon itself. Then, through interleukin-18, we make histamine. and mast cells. And then through histamine receptor site number 1, we come back and spin it. And now you’ve just got this spinning feedback loop. So, the glutamate will make you anxious, the histamine will give you allergies and make you anxious. And you’re allergic to everything, and you’re feeling horrible. Now, it doesn’t end there, Dr. Dad. It then goes on to make something called gast dermins that creates pyroptosis, where it actually starts punching a hole in the cell membrane. And you’re only going to be as healthy as your cells are. Just a little background. You know, we’re made up of trillions of cells, and each one of them has what’s called a lipid bilayer, made from lipids, which comes from fats. And you’re only going to be as healthy as those membranes are. So that’s why we coined an interesting phrase. Cellular CPR. Construct the cell. Protect the cell. And restore the cell membrane. And we believe that’s going to be revolutionary in the functional medicine world. So… It’s not hard to figure out that if you start punching holes in the cell membrane, that’s not a good thing, okay? Bob Miller 00:31:22 Now… There’s an interesting molecule called NAD. Thicotide adenoside dinucleotide. And anybody who’s in the, you know, listening to the health podcasts and things, they’re… They’re, they’re learning about NAD. And I’m going to show you a chart later, all the good things that NAD does, but For the most part, it helps what’s called sirtuins. And sirtuins are quite interesting. If anybody’s looking at longevity. The sirtuins is where they’re looking at.Because sirtuins turn on good things. Turn off bad things. And I’ll show some charts on that later. So for right here, this sirtuin uses NAD, to slow down NF-kappa-B. CERT 2 uses NAD to slow down an ORP3. So, if we’ve got genetic weakness on these, or we don’t have enough NAD, We don’t hold this pathway back. Make sense? Dr. Deb Muth 00:32:24 Yeah, makes perfect sense. Bob Miller 00:32:25 Now, I’ll show this a little bit later. So, people are like, oh, well, I’m gonna start taking some NAD. Dr. Deb Muth 00:32:31 Right. Bob Miller 00:32:32 And there’s functional doctors who give NAD intravenous. It was just this morning, I was talking to a woman who said, Oh my gosh. I went and got intravenous NAD, and it took me a month to recover from that. Dr. Deb Muth 00:32:45 Hmm. Bob Miller 00:32:46 what happens is, and I’ll show this in a little more detail, there’s an enzyme called CD38, that’s stimulated by NF-kappa-B. And it takes NAD, To make intracellular calcium. that stimulates NLRP3 and actually makes things worse. So, if we have this guy upregulated, and I’ll show a chart what does that. taking NAD will make you worse. Again, when I go into the software, I’ll show you that whole pathway, so… I would encourage people, you know, just don’t go out and start taking massive amounts of NAD, you know, stick your toe in the water, see how you do. Because everything you’ve heard about, how good it is, is true, unless this guy says, oh, thank you very much, let me make more inflammation. Now, this might be part of our innate immune system, that if we have some pathogen that’s gonna kill us. By golly, we want that to happen. But if this is happening by environmental factors, Then it’s detrimental. So the immune system that protected us a thousand years ago now might be turning on us because of the environmental factors that we showed earlier. All right. Then there’s an enzyme called PARP that’s NAD-dependent, and that actually repairs strain breaks in your DNA. Now, the next thing that happens… is there’s an enzyme called NADPH oxidase that gets stimulated. and something called INOS. Now, I’m sure most people know about nitric oxide. It’s a gas that dilates your blood vessels. That’s why sometimes they’ll even give people drugs, nitroglycerin, to boost their nitric oxide. That’s why people are doing beetroots and other things to boost their nitric oxide. But there’s an OS3 enzyme that makes the nitric oxide that’s good for blood flow. But there’s an INOS That makes nitric oxide to kill pathogens. probably might be the third or fourth time I’ve said this. That’s a good thing, unless it isn’t. So, if it’s killing some pathogen, great. It was just misfiring. it combines… With superoxide that’s made by this enzyme, and makes something called peroxynitrite, which is one nasty free radical that chews you up and spits you out. So, the NOx enzyme, NADPH oxidase, uses NADPH, To make this free radical called superoxide. If we have time, we’ll get into it. NADPH is what your body needs to recycle your antioxidants.So, I coined the phrase, the NADPH steel. Where the NOX enzyme takes this very important NADPH, And rather than being useful, makes superoxide. Now, again, is that fine if you’ve got some bacteria to kill? Of course. But if it’s just chronically running, it’s just making all this chronic inflammation. Then it makes something called hydrogen peroxide. And we need to clear hydrogen peroxide by 3 enzymes, catalase, thyroid reduction. And glutathione peroxidase. If we have genetic issues on here, or we don’t have the cofactors. There’s something called the Fenton reaction, discovered in 1895 by Dr. Fenton. Where hydrogen peroxide combines with iron to make what are called hydroxyl radicals. And guess what they do? They create lipid peroxides, That damages your cell membranes. Now, again, the body’s pretty darn amazing. We have glutathione, And here’s where your body’s taking glutathione and recycling it. But look who’s needed to recycle it. NADPH. So, if this guy up here is chewing it up, We don’t recycle our glutathione. And then an enzyme called glufon peroxidase 4, Takes this damaged lipid and repairs it. So, here we’ve got this protecting, we want to protect it by not having this happen. But then we also need this guy to do the restoration. So, there’s a lot that can go wrong in here, Dr. Deb. Dr. Deb Muth 00:37:07 There’s a lot that could go wrong. And I can imagine some of my listeners are thinking that lipid peroxidase, is that the same thing as what they’re thinking of when we talk about lipids and cholesterol? Is that the same process that’s happening there? Bob Miller 00:37:22 Well, no, no, the lipids can be used to make cholesterol, but here we’re talking about where they’re going to build the cell membrane. And they’re being… and they’re being, destroyed. If anybody would like to see a visual representation of this, just go on YouTube. And type in, ferrooptosis Animation. cool little video, it’s about 3 minutes long, and it shows the lipids coming over, being oxidized, and now GPX4 fixes them, so… YouTube, Pharaoptosis Animation, cute little video. It’s just that really… Shows vividly what we’re… what we’re talking about here. Now, this is… Dr. Deb Muth 00:37:59 And so this is very common, too. Like, a lot of people do hydrogen peroxide IVs. Dr. Deb Muth 00:38:04 And so, if somebody doesn’t know their genetics, they could have a problem with doing those, just like they could doing the NADHIVs, correct? Bob Miller 00:38:13 Sure, yeah, yeah, yeah. So, I’ve talked to so many, you know, of course, the hydrogen peroxide kills pathogens. I mean, that’s what it does. So… but I’ve spoken to so many people that said. I had one client that said they’ve never been the same after having one hydrogen peroxide infusion. Dr. Deb Muth 00:38:30 Interesting. Bob Miller 00:38:31 Yeah. So… it can be… I see why people use it, because it. Bob Miller 00:38:36 pathogens, But on the other hand. And now’s a good time to speak about… I don’t have it on here, but there’s a, there’s an enzyme called the HFE gene. And that is what causes you to absorb iron. And there’s mutations in it that cause something called hemochromatosis. Were you overabsorb iron? Now, true hemochromatosis is when both parents give you a mutation. But there’s now growing evidence even a heterozygous can cause a little bit more iron absorption, not to the human chromatosis point, but overabsorption. So, if you overabsorb iron, And you have too much hydrogen peroxide that’s not cleared, All kinds of inflammation. Now, what’s happened is sometimes this inflammation Will damage the red blood cells. And some well-meaning doctor says, oh, you need some iron. And they take iron and it makes it worse. So, can’t tell you how many people I’ve said, you’ve got the overabsorption of iron, and they say, well, that can’t be right, because I’m low in iron. Well, that could be because it’s being chewed up here. Dr. Deb Muth 00:39:40 Sure. GPX1 and TXN turn it into, to water. The, catalase turns it into water and oxygen. Dr. Deb Muth 00:39:58 Now, I see a lot of my clients who have mutations or SNPs on that GPX gene, on that glutathione gene. And they really struggle to clear a lot of their toxins. Bob Miller 00:40:12 Sure. Dr. Deb Muth 00:40:14 Yeah, absolutely. Well, GPX4. Bob Miller 00:40:18 is what, repairs, but you can see GPX1 Is what uses glutathione. To turn hydrogen peroxide. So, but it all depends upon having enough glutathione. Dr. Deb Muth 00:40:30 Yeah. Bob Miller 00:40:31 Well, guess who controls making a glutathione? Dr. Deb Muth 00:40:34 Nerf 2. Bob Miller 00:40:37 So, if you have a keep one weakness, or strength to two… I’m sorry, keep one is too strong. Nrf2 is too weak. You don’t make glutathione. So, when a lot of people do that, it’s like, well, I’m gonna take glutathione. Dr. Deb Muth 00:40:51 Right. Bob Miller 00:40:52 And some do great, and some do poorly. You know, because… and I’ll show this on one of the other charts. You can see here that the, The glutathione has to be recycled. And if we don’t recycle it, it actually turns into superoxide free radical. So… NADPH are the cofactors, For taking the oxidi… here’s oxidized glutathione, here’s reduced. So, this is a good glutathione. After it does its job, you can see it becomes oxidized.We need to recycle it. Well, if we have weakness on the enzyme that does that, or a weakness in Nrf2, or not enough NADPH. The oxidized glutathione never gets recycled. So, I’ve talked to a lot of people who said, oh, glutathione made me so sick, and say, well. Dr. Deb Muth 00:41:43 Yeah. Bob Miller 00:41:44 You need it, but you need to recycle it. Dr. Deb Muth 00:41:46 Can you speak for just a brief moment, too, about MTHFR? That is a very popular gene, it’s all over social media as the major gene, but can you speak to a little bit about that, and how that fits into this whole process of things? Because it is just such a small piece. Dr. Deb Muth 00:42:04 understanding genetics. Bob Miller 00:42:06 Yeah, to be honest, it drives me nuts. Dr. Deb Muth 00:42:08 Me too. Bob Miller 00:42:11 Alright, so… You know, there are people on social media I won’t say what I think, I’ll be kind. But… But the, And, you know, they might mean well. But they talk about, if you have MTHFR and COMT and PEMT, that’s… oh my goodness, that’s horrible, and we’ll fix that for you, and you’ll be fine. Bob Miller 00:42:36 it just irritates me to no end. And it really could get anybody who’s doing this legitimately in trouble. I mean, I’m afraid someday, you know, there might be some cracking down on this kind of nonsense. Now, to answer your question about MTHFR. Dr. Deb Muth 00:42:51 I mean, it really is, but I’ll tell you what, why don’t we hold that thought until I go to another map and I can actually… Okay. Bob Miller 00:42:56 But the real… the cliff notes is the MTHFR puts a methyl group on your folate, which is needed, but it has gotten way, way, way too much attention. And people learn they have MTHFR, and they start taking a multivitamin with methylfolate, then they take a B vitamin with methylfolate. Dr. Deb Muth 00:43:13 And they’re pushing it too hard. Bob Miller 00:43:15 Yeah. So I can’t tell you how many people I’ve helped by saying, stop it. Dr. Deb Muth 00:43:20 Yeah, take less of it. Bob Miller 00:43:21 Take less of it, yeah. So, yeah. Yeah, there’s a… If somebody, say, ranked the enzymes at their level of importance, MTHFR might be 40 or 50 on a scale of 100, you know. Keep one Nerf two. big deals. Dr. Deb Muth 00:43:40 deals. Bob Miller 00:43:41 NQO1 that I didn’t even talk about yet, NQO1, takes your, NA… your NAD goes into NADH, To make electrons for the electron transport chain. you need NQ01 to bring that back. If that’s not working, and I’ll show you on the NAD map how disastrous that can be. Now, the next piece is here, and I think You know, if you talk to any school teachers and say, if you’ve taught for more than 10 years, how are the kids today? Every one of them says, more ADD, ADHD, more autism. Just look at human beings, we’ve never been so agitated. You know, everybody, and it might be a social media thing, but people take a position on something, and if anybody doesn’t share that position, they view them as the enemy. Dr. Deb Muth 00:44:29 And it’s kind of scary what’s happening to us. Bob Miller 00:44:33 So, we can’t agree to disagree anymore. We see anybody who has a differing opinion as the enemy. And, you know, there was… there’s people that didn’t have Christmas dinners together, because they had political differences, like… Dr. Deb Muth 00:44:44 Excuse me. Bob Miller 00:44:45 can’t you put your political differences aside to have Christmas together, you know? Dr. Deb Muth 00:44:49 Right? Bob Miller 00:44:50 become that, you know, no matter what your position is, and I’m not saying anyone’s right or wrong, I’m just saying. You know, in the old days, they used to say that the Republicans and Democrats in Congress would argue policy and then go have dinner together. And now everybody’s all up in arms, angry. Dr. Deb Muth 00:45:05 Yeah. Bob Miller 00:45:06 So… There’s likely multiple reasons for that. But let me show you one of them. That, you know, to what degree this is… very important, we don’t know, but I think We’re beginning to believe this is very important. So, there’s something… there’s a neurotransmitter called GABA. And God buys the don’t worry, relax, be happy. Chill. Okay. Dr. Deb Muth 00:45:31 Nobody has enough of that anymore. Bob Miller 00:45:33 Well, yeah, you’ll be surprised what I’m gonna show you. So, let me see if I can find a, Let me see if I can find the right slide here. Let me look for it here. So, there’s something called a GABA receptor site. And here you can see… This is a neuron, and this is where you, The neuron normally is excitatory. However, there’s normally low chloride in the neuron. Dr. Deb Muth 00:46:09 Hmm. Bob Miller 00:46:10 So, GABA itself is neither relaxing. For excitatory, all GABA does, it opens up what’s called a chloride channel. And then chloride, which has a negative charge, will flow into the neuron. Follow me there? Dr. Deb Muth 00:46:26 Yep. Bob Miller 00:46:27 And as it does, it changes this from a positive charge to a negative charge, And it’s relaxing. and inhibitory. Dr. Deb Muth 00:46:34 Hmm. Bob Miller 00:46:36 Now, on the other hand, there’s enzymes called NKCC1, That will push chloride in. and KCC2 that will bring chlor… oops and bring chloride out. And then there’s a sodium channel. And, sodium has a positive charge. And glutamate will push that in. So, as long as this is happening. And GABA says, receptor sites, open, chloride goes in, Chill. However, If NKCC1 Pushes extra chloride in. KCC2 doesn’t pull it out. and GABA hits the receptor site, the GABA comes flowing out, Sodium comes in, And now it’s excitatory. So Gabba didn’t change. GABA just opened the receptor site, that’s all it does. Dr. Deb Muth 00:47:33 Yeah. Bob Miller 00:47:34 But it’s the chloride balance that’s going to determine whether this is relaxing or not. Now, these are the things that go along with when they lose that KCC2 or gain NKCC1. Pain and sensitivity, burning electrical, neuropathic pain. Normal touch hurts. Sound and light sensitivity. Tinnitus can flare. Headaches and migraines. Seizure tendency. Body jolts. Spasticity, cramps, stiffness, startle reflex. Trouble falling asleep, non-restorative sleep. Anxiety, stress, reactivity, that’s what we have now. Hyperarousal, panic-like surges, irritability, racing thoughts. Brain fog, slowed processing, working memory slip-ups. Mental fatigue. Episodes of racing hearts, sweaty palms, guts on edge. Those are all the things that happen when this GABA switch occurs. Now, here’s what happens, and this is what I’m going to be presenting at an autism conference. When you have a newborn, they need that NKCC dominant to develop. By early childhood, it should… or, sorry, early adulthood. we should move over to the KCC dominant, that’s the taking the chloride out. Nice-looking 25-year-old boys, functioning very well. However, when we get microglia M1 upregulated. Because of environmental toxins, processed foods, Tylenol, aluminum. they stay in NKCC1 dominant, and there’s ADD, ADHD, Autism, the whole spectrum. because… They’ve not moved over to the… They’ve not moved over to the KCC2. And again, this is caused by… Environmental factors. Stimulating the microglia. And then, interleukin-1, interleukin-18 weakens KCC2, interleukin-1 beta, Strengthens NKCC1. high chloride. We open up the chloride channel, In Rebell Excitatory. So, I think when, When the pediatricians get ahold of this, they’re going to be very excited to know that This could be why we’re seeing such a rise, and not just autism, but ADD, ADHD, anxiety, the whole shit mess. Dr. Deb Muth 00:49:58 thing. Bob Miller 00:49:59 Yeah, so… and you can see NF-kappa-B stimulates that. These stimulate it, and I think that’s why everyone’s getting so anxious. Now, there’s a little bit more to it, and we’ll get into this when we look at some of the maps, but… The, the glutamate, Which is excitatory. will stimulate the NMDA receptor, make more glutamate, And glutamate will inhibit KCC2. And then we also need an astrocyte To, take both ammonia And glutamate, and… Turn them back into glutamine. And I’m going to talk to you a little bit about arachidenic acid, and if we have too much arachidenic acid. or TNFA is upregulated, that doesn’t happen. Ammonia goes up, and there may be multiple reasons for this, but this is a reason why some of the autistic kids do flapping. Dr. Deb Muth 00:50:49 Hmm. Bob Miller 00:50:50 Because they’re not clearing their ammonia. And you can tell if somebody has high ammonia by… they get that old person smell, you know. Dr. Deb Muth 00:51:00 Yup. Bob Miller 00:51:01 your vehicle cycle’s not taking out the, the ammonia. Now, last pathway here. There’s growing interest in mast cell activation. So, back here, we talked about peroxynitride. And that will stimulate mast cells, and those are white blood cells that are your best friend, unless they’re your worst enemy. Then it’ll make histamine. And there’s enzymes called histidine decarboxylase that’ll make more. Dr. Deb Muth 00:51:28 I’m sure everybody’s heard of DAO, the enzyme that degrades histamine. Yep. Bob Miller 00:51:31 We can have genetic weakness, we don’t make that. There’s an enzyme called histamine and methyltransferase, That, That breaks down the histamine. Then if we don’t do that, it’ll get stuck in the histamine receptor site. And then it’ll make something called, renin. Which will cause angiotensinogen to turn into angiotensin. One, that turns into angiotensin II,And that’s where people make aldosterone, where they’ll get the, The swollen ankles and high blood pressure. But interestingly, there’s an enzyme called ACE2, that takes this guy and turns it into angiotensin 1-7, Which is anti-inflammatory and also inhibits… TNFA. Now, you can have weakness on ACE2, But… and anybody’s saying, that sounds familiar? Dr. Deb Muth 00:52:25 That’s where COVID comes in, using ACE2. Bob Miller 00:52:28 And now we just found there’s literature that if you get COVID long enough, it can actually make ACE2 not be able to work as well. So look what it does. It comes down here, stimulates the NADPH oxidase, More superoxide. More peroxynitrite. And we’re on a cycle here. We’ve actually named this the Home Cycle Hypothesis, the proposed feed-forward loop. That just keeps feeding on itself. All being caused by… Primarily, The environmental factors. But hitting those who have genetic weakness the hardest. That’s why. Dr. Deb Muth 00:53:08 To the people. Bob Miller 00:53:09 Don’t live in a moldy house. One person is sick as can be, and the other person says, well, you must be imagining things, because I don’t feel anything. Dr. Deb Muth Yeah. Same thing with long haul, right? Two people can both get sick, one gets sick and never seems to recover, and somebody else gets sick, and they have absolutely no problems with it at all. Bob Miller 00:53:30 Sure. Well, think about it, if you get COVID, and ACE2 is weak, and some of this other stuff is going on. This thing just starts feeding upon itself. Dr. Deb Muth 00:53:38 Keep creating more inflammation, more complications, nothing’s calming down. Bob Miller 00:53:43 Yeah. Now, you, you ask about, MTHFR. So, this is the, this is the, the software called Functional Genomic Analysis. There’s a demo report we have. So, let’s talk a little bit about, MTHFR. So, we actually have a map called a methylation map. Now, what happens is, when you do your saliva test, you, you know, you spit, you put some saliva. in a collection kit, goes to a lab, takes out the DNA data, sends it to the computer, and now you can actually see it visually. Okay. So, it’s gonna take a second for this, data to load up, it’s, and each of these Circles, each of these ovals, is an enzyme. And the data gets loaded up to see where it is. So, until it gets loaded up here, I didn’t preload this. There it goes. So… The primary thing about methylation is There’s a nasty substance called homocysteine that, if it’s too high, can really be detrimental. The body takes methylfolate, and combines with methyl B12, To bring this back up to methionine. And then through the MAT genes, we make SAMI, S-adml methionine. Which is involved in so many processes. Then after it does its thing, it turns back into homocysteine. And this thing needs to keep spinning around. That’s why, you know, it’s a good idea to keep homocysteine at, do you have a number that you’d like? 7, 8? What do you like for a number? Dr. Deb Muth 00:55:24 Yeah, I like mine below 7. Bob Miller 00:55:26 Yeah. So if the homocysteine goes too high. It, caused all kinds of problems. So, here’s where you ask about the MTHFR. So, here you can see on this individual. I click on MTHFR, and you can see it comes up here, here’s the C677. And you can see here where it says, variants. I’ll… I’ll draw in case somebody’s having a hard time seeing that. So, you can see there’s nothing in there. That means there’s no genetic mutations. If one parent would have given a mutation, there’d be a 1. If both parents did, there’d be a 2. Now, here’s why Yes, methylation is important, I’m not saying it isn’t important, but look at this MTHFRC677. In my software. Only 42.5% of the population does not have a mutation. 44.7% have won. 12.9 have 2. So, this isn’t some rare, oh my god, I’m gonna die… Kind of thing, yeah. Dr. Deb Muth 00:56:27 Right. Bob Miller 00:56:28 So, And then what happens is that, and again, I’m not dismissing methylation, I… we could do a whole show on methylation. Bob Miller 00:56:36 get it. But I think that what people are doing is they’re, they’re learning about MTHFR, they get it measured, they panic. They start taking massive amounts of methylfolate, which many times is to their detriment. Dr. Deb Muth 00:56:50 Well, it’s… and isn’t it true, too, with MTHFR, like, you have to also look at MTR, MTRR, and the more we stack up of those, the more complicated than MTHFR can be. It’s not… it’s not as simple as just saying MTHFR 677 versus 1298. It’s more complex than that, kind of like what you’ve already shown with some of the other things. There’s more to it than just that one little sliver. Bob Miller 00:57:17 Oh, sure, well, let’s take a look. So, remember I said there’s a cofactor? One of the cofactors is called FAD. Just a Bob Miller observation, that’s all. But when people have trouble with their riboflavin and they don’t have enough FAD, They’re doing much worse than people who have just a C677. So, right here, you could have perfect C677th. And if you don’t have the cofactor, it’s not gonna work, okay? Dr. Deb Muth 00:57:48 And as you said, there’s an MTR enzyme. Bob Miller 00:57:51 that takes methylfolate and methyl B12, to spin it around. So, here on this individual. here’s your… here’s your B vitamins, or I’m sorry, your B12s. There’s an enzyme called TCN1 that takes it from the stomach into the blood. Then there’s other enzymes that take it from the blood into the tissue. And if you’re having trouble here. Well, then you’re not going to have this working, so… Even if you don’t have MTHFR, And you have MTR, like this, no, I’m sorry, this person doesn’t. But they have the MTRR, and then they don’t have enough B12, this isn’t gonna work, aside from that. And then there’s a middle pathway. And then there’s enzymes called the MAT1. they take the methionine to the salmon. If that’s not working, we stick… we get stuck in methionine. So, it’s, it’s not just an MTHFR. And then, one of the things that people forget about. is through these CBS enzymes and CTH, We make cysteine, which is needed to make glutathione. The master antioxidant. So, it really is that… I call it the, The 3D chess game played underwater. Dr. Deb Muth 00:59:07 It really is. I mean, I see people who have CVS, COMT, glutathione, MGHFR genes. And some of them function just fine. Like, they have Like, I look at this person and I’m like, oh my gosh, I don’t know how they’re functioning because they’re double mutated on so many pathways, but yet they don’t have a lot of symptoms, they don’t have a lot of complications. Somehow their body has figured out a way to adapt to what it has so it can stay alive and it can function at a high functioning level. Bob Miller 00:59:36 Yeah, and they may be, you know, eating right? Yeah. Staying out of a moldy house. reducing stress. So, it’s diet, it’s stress, it’s genetics, environmental factors. So, yeah, we can’t just say somebody’s gonna be good or somebody’s gonna be bad. You know, some people get scared, oh, I got all these, it’s like, well… Bob Miller 00:59:56 Are you living in a moldy house? You know, and if you live in a moldy house and your glucuronidation pathway doesn’t do well, or if you’re, you know, a smoker, or you’re constantly eating junk food, I mean, all. Bob Miller 01:00:07 things come together. Although, you know, when we focus on genetics, we’re well aware that this is just a piece of it. You know, you could have identical twins, Genetically, and if one… Is exposed to mold and smokes and drinks and stressed out. They’re gonna be a whole lot sicker than their sibling. Bob Miller 01:00:28 Yep. Dr. Deb Muth 01:00:29 Yeah, it’s that concept of taking twins, and one gets raced with one family, and one gets raced with another family, and they don’t have the same… problems that… that each other have, you know? It’s a very unique situation, we don’t think about that enough. Bob Miller 01:00:44 Alright, so again, genetics loads the gun, environment pulls the trigger. So, if you’ve got a loaded gun, but you don’t have the triggers, you’re okay. Dr. Deb Muth 01:00:53 Yeah. Bob Miller 01:00:54 Yeah. So, remember I said I was going to talk about NAD? So, here’s NAD, and what it does, it turns into NADH. And what NADH does, it, Comes down this pathway, what’s called the electron transport chain. And that makes your ATP, that’s your energy. So, if this wasn’t working, we wouldn’t be alive, because we wouldn’t have energy. So it donates an electron, that’s why it’s called electron transport chain. So, we need NAD, To make this, to make the energy. But remember I said that NQ01, this would probably be, like, on my top 10 list of… Bob Miller 01:01:36 Much more important than MTHFR. This one takes NADH back to NAD. If we’re stuck over here, We’re low in this NAD+, But what happens is, NQO1 also provides CoQ10. And CoQ10 Is what’s needed for the electron transport chain to flow. So if we get too many electrons up here. And they don’t turn them into energy. They make a nasty free radical called superoxide. Okay. Now, NAD plus also makes NADPH, And that is needed. Remember I said we need to recycle our antioxidants. So, if we have a problem with FAD from riboflavin. Yeah, we don’t have enough NADPH, Glutathione’s not getting recycled, and you’re gonna be inflamed. And you take glutathione, you’ll feel worse. There’s another enzyme called thimoredoxin. Same thing, needs NADPH and FAD. And same way with your nitric oxide, there’s an enzyme called NOS3, That makes the nitric oxide that dilates your blood vessels. And if we don’t have enough NADPH or fat, You’re gonna make superoxide. Rather than nitric oxide. Now, remember

This episode is brought to you by the⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Primal Tallow Soaps & Balms.⁠⁠⁠⁠⁠⁠⁠⁠ Join us as cardiologist Dr. Pradip Jamnadas (MD) explains the link between chronic inflammation and visceral fat. In this episode, we explore how high insulin levels act as a metabolic brake, preventing fat oxidation and cellular renewal. Dr. Jamnadas shares his vast cardiovascular expertise to explain the science of cellular autophagy and why prolonged fasting is a clinical powerhouse for cellular repair. By shifting the focus from calories to hormonal optimization, this episode offers a masterclass in preventative medicine. This episode is essential for anyone interested in the science of fasting, both intermittent fasting and the magic of the 36 hour fast, and how it can improve metabolic flexibility. In This Episode, We Reveal:The Dangers of Visceral Fat: A clinical review of why ectopic fat storage in the abdominal cavity is the primary driver of systemic inflammation and cardiovascular disease.The Insulin-Adipose Connection: Understanding the hormonal "lock" that prevents the mobilization of stored energy and how fasting restores insulin sensitivity.Autophagy & Cellular Maintenance: A scientific breakdown of the body's innate repair mechanism and the specific fasting durations required to trigger protein recycling.The "Starvation" Myth vs. Clinical Fasting: Differentiating between nutrient deprivation and the controlled, physiological state of metabolic switching.Electrolytes & Metabolic Support: Why sodium, magnesium, and potassium are non-negotiable for maintaining cardiovascular stability during extended fasting windows.Worst foods: Identifying the "healthy" processed foods that trigger metabolic dysfunction and the four nutrient-dense pillars of health.

Dr. Fuhrman explains the healing power of time-restricted eating, meal timing, and how proper digestion supports long-term recovery. #FastingBenefits #SleepAndDiet #MealTiming

The melanocytes giving pigment to your skin right now might be older than your car. They have been sitting in your dermis for decades, and unlike the cells on your skin's surface, they do not get replaced. They have to keep themselves clean which happens through autophagy.In Part 2 of our autophagy deep dive, we get specific about how skin handles autophagy differently from other parts of the body. We unpack why long-lived cells like fibroblasts and melanocytes depend on this cleanup process, what happens when it fails, and how it ties directly to gray hair, hyperpigmentation, sagging skin, and that brownish dullness no serum seems to fix.We also introduce one of the most overlooked players in this entire conversation, and explain why we believe it is the next NAD. If you want to understand what is actually happening underneath your skin as it ages, and what tools we have to intervene at the cellular level, this episode is for you.What's Discussed:(01:06) Why skin needs autophagy more than almost any other organ(03:07) The cells on your face that may be older than your car(04:25) The 2013 paper that linked autophagy failure to dermatitis(08:44) Zombie mitochondria and why photo-aged skin makes bad collagen(12:25) Senescent cells, SASP, and how a few bad cells poison the dermis(18:38) The 2019 Drexel rapamycin trial that proved this works in humans(23:22) The 2024 spermidine study that changes how we think about autophagy(29:51) Why your skin barrier collapses without this one moleculeResources Mentioned:Biohacking Beauty Podcast with Dr. Scott Sherr: Stress & Light on Your Skin Are Aging Your Entire Body Podcast/dr-scott-sherr-stress-light-on-your-skin-are-aging/2024 Study on endogenous spermidine as essential for rapamycin-induced autophagy and longevity: pubmed.ncbi.nlm.nih.gov/39212197/Young Goose Companion Booklet: younggoose.com/pages/autophagy-skin-activate-your-bodys-anti-aging-system Find more from Young Goose:Use code PODCAST10 to get 10% OFF your first purchase, and if you're a returning customer use the code PODCAST5 to get 5% OFF at younggoose.comInstagram: @young_goose_skincare

Dr. Saupe explains how restoring mitochondrial function can reverse cancer by reactivating natural cell death and cooperation. #MetabolicHealing #Mitochondria #CancerReversal #HealthTalks

In this episode of Accelerated Health with Sara Banta, I'm joined by Melanie Avalon to talk about how intermittent fasting can supercharge your biohacking journey and transform your energy, metabolism, brain function, and longevity.Intermittent fasting has become one of the most powerful tools for optimizing health, but many people still misunderstand how to use it effectively. Melanie and I explain what really happens inside the body during fasting, how it impacts fat burning, insulin sensitivity, inflammation, cellular repair, and mental clarity, and why fasting may be one of the most effective longevity strategies available today.We also discuss common fasting mistakes, who should approach fasting carefully, and how to personalize fasting for your unique health goals and lifestyle.If you've been curious about intermittent fasting, biohacking, metabolism, anti-aging strategies, or natural ways to improve your energy and health, this episode is for you.Follow Melanie Avalon:• Instagram: https://www.instagram.com/melanieavalon • Website: https://melanieavalon.com/ Supplements Featured In This Episode:• Acceleradine® Iodine https://www.acceleratedhealthproducts.com/products/acceleradine-iodine-supplement  • Accelerated AMINOS® https://www.acceleratedhealthproducts.com/products/accelerated-aminos • Accelerated Ancient Salt® https://www.acceleratedhealthproducts.com/products/accelerated-ancient-salt-4-oz Not sure what food to eat and avoid? This guide is for you.⬇️

What if your skin could literally rebuild itself from the inside out? In this episode, we break down one of the most powerful and misunderstood biological processes in the human body: autophagy.From its Nobel Prize-winning discovery to the molecular machinery that drives it, we walk you through exactly what autophagy is, how it works at the cellular level, and why it matters far more than most people realize for skin aging.We explore the two master switches that control autophagy, mTOR and AMPK, and how the constant tug of war between them determines whether your cells are in build mode or cleanup mode. We also explain why most people in the modern world are stuck in permanent mTOR activation, and what that means for how their skin ages over time.This is Part 1 of our deep dive. In Part 2, we go skin-specific and break down exactly how autophagy renews your skin at the tissue level.What's Discussed:(0:19) The "phoenix process": the cellular mechanism rebuilding your skin from the inside out(3:14) What autophagy actually means, and why the science world ignored it for 30 years(4:47) How baker's yeast cracked the code that won the 2016 Nobel Prize(7:14) Inside a single skin cell: the step-by-step breakdown of how autophagy actually works(10:22) Why autophagy is not destruction, and what this means for your collagen supplements(16:44) The two master switches controlling whether your cells build or clean(20:10) The everyday habit silencing your body's most powerful anti-aging system(26:17) Why aging skin isn't broken, it has just never been told to cleanResources Mentioned:Biohacking Beauty Podcast: Ben Azadi: Why 93% of Americans Are Aging Too Fast + What to Do About It: podcasts.apple.com/us/podcast/ben-azadiFind more from Young Goose:Use code PODCAST10 to get 10% OFF your first purchase, and if you're a returning customer use the code PODCAST5 to get 5% OFF at younggoose.comInstagram: @young_goose_skincare

In this episode, Dr. Jockers breaks down the science of autophagy and mTOR, two crucial processes for cellular repair and growth. Learn how balancing these pathways is key to slowing down aging and optimizing longevity. Discover the powerful impact of fasting, exercise, and ketosis on activating autophagy and inhibiting mTOR. Dr. Jockers explains how these strategies help reduce inflammation and promote healthy muscle mass. You'll also hear about the best foods and supplements to support your body's natural healing processes. From polyphenols to intermittent fasting, this episode gives you the tools to boost cellular regeneration and maintain vitality. In This Episode:  00:00 Autophagy Basics 00:23 Podcast Intro and Resources 03:28 mTOR Explained 04:21 Autophagy and AMPK 05:11 Longevity Risks and Balance 07:10 How to Inhibit mTOR 08:55 What Increases mTOR 12:21 Exercise Spring Load Strategy 13:22 Fasting Window and Meals 16:17 Longevity Takeaways and Outro   Unwind with Purality Health's KSM 66 Ashwagandha, clinically proven to reduce stress and improve overall health. Its advanced nano-absorption technology ensures you get this ancient herb's full benefits. Experience better sleep, enhanced memory, and a calmer mindset. Enjoy a special buy one, get one free offer now! Each order comes with a six-month satisfaction guarantee. Visit longevityroot.com/drj to claim your deal and start feeling less stressed today. Say goodbye to unhealthy cooking oils and elevate your meals with Kettle & Fire's 100% grass-fed beef tallow. Free from seed oils and preservatives, it's the cleanest, healthiest fat you can use for cooking. With a high smoke point of 420°F, it's perfect for grilling, roasting, and sautéing, bringing both great flavor and nutritional benefits. For a limited time, enjoy 25% off sitewide with the code DRJOCKERS at checkout. Visit kettleandfire.com/drjockers to shop now!   "Autophagy clears out what's broken so your body can rebuild stronger, cleaner, and more efficient cells." ~ Dr. Jockers   Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean TuneIn Radio     Resources: Visit renewyourhair.com/drj to claim your exclusive offer Visit kettleandfire.com/doctorjockers with the code DRJOCKERS   Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https:/www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/   If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/ 

Urolithin A (MitoPure)--Mitophagy, Muscle Recovery, Immunity, and Skin Health: Dr. Brad Currier, clinical trial manager at Timeline, a Swiss biotech company, details urolithin A (MitoPure), a postbiotic derived from pomegranate precursors that most people cannot produce due to microbiome differences. Currier explains MitoPure's mechanism—stimulating mitophagy to recycle dysfunctional mitochondria—and reviews evidence from multiple clinical trials. He reveals a Sports Medicine study in elite male distance runners showing reduced creatine kinase and lower perceived exertion, suggesting improved recovery, plus trials in middle-aged and older adults showing improvements in strength, six-minute walk test, and VO2 max at 500 mg–1 g doses. They also cover a Nature Aging immune study reporting rejuvenation of stem-like CD8 T cells with improved mitochondrial fatty acid oxidation, ongoing research directions, supplement quality/testing for athletes, and topical urolithin A skincare trials and partnerships, including L'Oréal Lancôme.

In this episode, Dr. David Jockers dives into the transformative benefits of a seven-day water fast. He explores how fasting balances blood sugar, improves insulin sensitivity, and triggers deep cellular healing, making it a powerful tool for weight loss and overall health.   You'll learn how fasting helps the body burn fat, repair mitochondria, and reset the immune system. Dr. Jockers breaks down the science behind autophagy and mitophagy, showing how your body eliminates damaged cells to replace them with healthier, stress-resistant ones.   Plus, discover the critical role ketones play in brain health and how fasting elevates stem cell production. With insights on how to prepare for and break a fast, you'll get practical tips for maximizing the benefits of extended fasting. In This Episode:  00:00 Key Fasting Milestones 04:17 Why Fast Seven Days 04:53 Blood Sugar and Fat Burn 06:23 Ketones and Brain Benefits 07:40 Autophagy and Mitochondria 08:37 Gut Microbiome Reset 10:20 Hormones Longevity Stem Cells 16:06 Research and Immune Tregs 18:08 Hour by Hour Breakdown 20:07 Five vs Seven Days 21:03 What to Drink While Fasting 22:54 Prep Meals Before Fasting 24:19 How Often and Exercise 25:29 Breaking the Fast Safely 26:50 Wrap Up and Final Thanks   Hair loss isn't just about age—it's about hair follicles getting stuck. AnaGain Nu by Purality Health uses a pea sprout extract clinically shown to reactivate follicles and boost regrowth. With their micelle liposomal delivery, your body absorbs it fast and effectively. Try it risk-free with a 180-day money-back guarantee and get a buy-one-get-one-free deal at RenewYourHair.com -  https://renewyourhair.com/drj.   Looking to boost your hair growth and enhance your skin health? Now's the perfect time to try iRestore's Elite Laser Hair Growth System and the Illumina Face Mask, both designed to give you thicker hair and smoother, more radiant skin. Take advantage of the Memorial Day savings event and grab this powerful bundle at an exclusive discount. Visit iRestore.com  and use code DRJOCKERS to claim your offer today.   "Fasting for 36–48 hours can reset your brain and dopamine, giving you a clearer mind and better mental health." ~ Dr. Jockers   Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean TuneIn Radio   Resources: Reignite hair growth with AnaGain Nu, risk-free with a 180-day guarantee and a buy-one-get-one-free deal! https://renewyourhair.com/drj Visit iRestore.com  and use code DRJOCKERS to claim your offer today Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https:/www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/   If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/ 

You broke a 5-day dry fast. Two days later, you've got a cold sore, a shingles patch, or that crushing post-mono fatigue is back. Almost everyone blames the fast. They're looking at the wrong window.The dry fast is the safest period your immune system experiences all year. Autophagy is destroying virus-occupied cells. Ketones starve viruses of the glucose metabolism they need. mTOR (the growth signal viruses hijack to replicate) is shut down. And NK cell activity is climbing. Inside that fasted state, viral replication is mechanically and metabolically near-impossible. That's why most people don't flare during the fast itself.The danger is the refeed. The moment food comes back, mTOR turns back on, autophagy shuts off, your T-cells are still parked in bone marrow, cortisol is still peaking, and T3 is still crashed. For 24 to 72 hours your antiviral defences are at zero — and any virus that survived the fast now has an open road to refill the reservoirs the fast just cleared. Worse, it can spread to nerve cells it never previously occupied.In this video I break down:— Why the dry fast creates a near-impenetrable antiviral state (4 mechanisms)— Why the refeed is the highest-risk window in the entire protocol (5 mechanisms)— Why a botched refeed leaves chronically ill patients MORE infected than they started— The bridge strategy: dry fast → water fast → controlled refeed with antivirals already on board— The full pharmacological stack: T3, L-lysine, monolaurin, acyclovir, ivermectin— Early warning signs of reactivation in the refeed window (and what to do)— Why this gets dramatically easier from cycle 3 onward— The T3 off-ramp as the second high-risk window most people missThis isn't a reason to fear fasting. It's the map of when the danger window opens and how to close it before food can.

10 Shocking Habits to Reset Your Health By Dennis J. Henson Here is a scripted Q&A session designed for our program. The Host (you) plays the role of the ‘Questioning Sceptic' who loves comfort, setting the Guest (me) up to deliver the hard truths. Host:  "We spend our whole lives seeking comfort—climate control, soft chairs, fast food. But what if the secret to living longer is actually making yourself uncomfortable... just for a few minutes every day?" Host: "Our returning guest today is Dennis Henson. Now Dennis, you sent over a list of topics that frankly looks… terrifying. You're saying that 'Comfort is the enemy of health.' What do you mean by that?" Guest: "Exactly that. We spend our lives seeking relaxation, climate control, soft chairs, and fast food. But biologically, to be healthier and live longer, you have to shock your systems. It's called ‘Hormesis'. Introducing short, sharp stressors, causes your body to over-compensate, becoming stronger and healthier." But let's pause here for a moment. I need to interject a voice of reason. When we talk about 'shocking' your systems, we aren't playing games. These are real physical stressors. Host: Yes! If you have a heart condition, high blood pressure, or any underlying health issue, some of this could be too much for you to handle. We want you to be healthy, not in the hospital. So, before you try any of these techniques, please consult your physician. Now that that's out of the way, let's dive into today's topic. Number one is something I avoid at all costs. You want us to take Cold Showers Or to bath in ice water.?!" Guest: "Yes! Specifically, for a ‘Thermal Shock'. This triggers 'Cold Shock Proteins' and a massive dopamine spike. It wakes your immune system and forces your vascular system to contract, essentially acting like a booster for your blood." Host: "Brrr. Alright, well number two is the opposite. You listed Sauna. Isn't that mainly for relaxing?" Guest: "Well not just relaxing. It Creates a ‘Heat Shock' Mimicking a fever, the body's natural way of killing invaders. This ‘Heat Shock' acts like a 'cleanup crew,' by repairing damaged DNA and fixing impaired proteins." It also triggers a profound physical purge. The deep, profuse sweating literally flushes toxins and heavy metals out through your pores, detoxifying your body from the inside out. Host: "Okay, hot and cold. Got it. Now, number three is about food. You're suggesting we stop eating?" Guest: Yes! But not all together, only for short windows of time. This is called ‘Metabolic Shock'. Intermittent Fasting convinces your body - food is scarce, triggering Autophagy, where your body devours its own damaged cells, leaving behind only the strong ones." Host: "That sounds intense. But this next one sounds a little weird... you think we should stop breathing?" Guest: Not all together! "It's called ‘Oxygen Shock' - Intermittent Hypoxia. You do this by... taking deep, rhythmic breaths to lower carbon dioxide, then exhaling fully and holding that 'empty' state until the urge to breathe becomes intense. The body responds to this temporary air starvation by producing more red blood cells and improving your tolerance to CO2, making energy delivery much more efficient." Host: "Okay - that makes sense. Number five is exercising, but you specify 'High Intensity.' Can't we just jog?" Guest: "You could-- but you really need an ‘Energy Shock'. Sprints or ‘High-Intensity--Interval Training' pushes your heart rate to its capacity. This shocks your mitochondria—your energy power plants— into growing stronger and multiplying to handle the demand. A slow jog doesn't do that."

What happens when you stop eating after 6 p.m.? Discover the connection between your metabolism and fasting so you understand when to eat and when not to eat, plus the benefits of having no food after 6 p.m.0:00 Introduction: What happens when you stop eating after 6 p.m.? 0:15 What to eat vs. when to eat0:50 Autophagy fasting benefits1:28 Late-night eating dangers3:01 Dopamine and late-night snacking4:03 How to stop eating after 6 p.m. Download Dr. Berg's Free Daily Health Routine: https://drbrg.co/45qtO07Eating after 6 p.m. can interfere with your body's natural repair system. Even if you're eating clean, nutrient-dense foods, late-night eating may still negatively impact your metabolism, recovery, and overall health.At night, your body is designed to enter autophagy, a deep cellular “clean-up” process where damaged cells and mitochondria are repaired and recycled. Autophagy only occurs when insulin levels are low. Every time you eat, insulin rises, which can interrupt this critical overnight repair cycle. This is why fasting after 6 p.m. is critical for optimal metabolic and cellular health.Late-night eating can also disrupt melatonin production, affecting sleep quality and recovery. Poor sleep then impacts digestion, increases stress hormones like cortisol, and can lead to unstable blood sugar levels the following day.Another major driver of late-night snacking is dopamine hunger. This is when cravings are triggered not by true physical hunger, but by boredom, stress, fatigue, or emotional habits, leading to unnecessary eating when the body should be resting and repairing.Dr. Eric Berg DC Bio:Dr. Berg, age 61, is a chiropractor who specializes in Healthy Ketosis & Intermittent Fasting. He is the Director of Dr. Berg Nutritionals and author of the best-selling book The Healthy Keto Plan. He no longer practices, but focuses on health education through social media.Disclaimer: Dr. Eric Berg received his Doctor of Chiropractic degree from Palmer College of Chiropractic in 1988. His use of “doctor” or “Dr.” in relation to himself solely refers to that degree. Dr. Berg is a licensed chiropractor in Virginia, California, and Louisiana, but he no longer practices chiropractic in any state and does not see patients, so he can focus on educating people as a full-time activity, yet he maintains an active license. This video is for general informational purposes only. It should not be used to self-diagnose, and it is not a substitute for a medical exam, cure, treatment, diagnosis, prescription, or recommendation. It does not create a doctor-patient relationship between Dr. Berg and you. You should not make any change in your health regimen or diet before first consulting a physician and obtaining a medical exam, diagnosis, and recommendation. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition.

A ketogenic diet put his ulcerative colitis into complete remission — off all medications, confirmed on colonoscopy. Dr. Nick Norwitz (PhD Oxford, MD Harvard) explains why evidence-based care isn't always optimal care, how keto rewires the gut and brain, and why GLP-1 drugs should catalyze lifestyle change, not replace it.CHAPTERS:0:00 - The most remarkable thing about my story is it's not unique1:14 - Welcome Nick Norwitz — Oxford PhD, Harvard MD2:02 - Ulcerative colitis, desperation, and keto remission5:34 - What medical school doesn't teach8:05 - Why evidence-based care ≠ optimal care15:53 - The carnivore-ketogenic IBD case series (10 patients)18:50 - Fiber elimination in pediatric Crohn's — 60–85% remission20:00 - Keto for depression: Ohio State trial — 69–71% reduction23:49 - Seed oils: the nuanced truth29:32 - Ketones and neurodegenerative disease32:52 - Autophagy, lateral habenula, and depression36:16 - Sonnenburg 2021: fermented foods beat fiber for inflammation37:20 - GLP-1 agonists: good tool, poor deployment43:29 - Statins slash GLP-1 by ~50% (Cell Metabolism, 2024)48:57 - ClosingREFERENCES:Carnivore-Keto for IBD (Norwitz et al., Frontiers, 2024): PMC11409203Keto for Depression (Ohio State, 2025): PMC12420795Fermented Foods vs Fiber (Sonnenburg, Cell, 2021): Stanford NewsStatins Slash GLP-1 (Cell Metabolism, 2024): pubmed/38325336Autophagy + Depression (Nature, 2025): NatureGUEST: Nick Norwitz, PhD MDHOST: Dr. Robert Lufkin MD | robertlufkinmd.com⭐ Enjoying the show? Please leave a 5-star review on Apple Podcasts — it takes 30 seconds and helps more people discover the science of health and longevity. Thank you!New episodes every Tuesday & Thursday. Subscribe so you don't miss one.Continue this conversation on Substack: https://robertlufkinmd.substack.comLies I Taught In Medical School — Free sample chapter: https://www.robertlufkinmd.com/lies/Web: https://www.robertlufkinmd.comYouTube: https://www.youtube.com/robertlufkinmdX: https://x.com/robertlufkinmdInstagram: https://www.instagram.com/robertlufkinmd/TikTok: https://www.tiktok.com/@robertlufkinLinkedIn: https://www.linkedin.com/in/robertlufkinmd/

On this episode of Vitality Radio, Jared dives into three cutting-edge supplements gaining attention in the world of longevity and metabolic health: fisetin, spermidine, and butyrate. These compounds work in complementary ways—supporting the body's natural ability to clear aging cells, promote cellular renewal, and optimize gut-driven metabolic signaling. Jared breaks down how “zombie cells” (senescent cells) contribute to inflammation and aging, how autophagy supports cellular efficiency, and why gut health plays a central role in cravings, blood sugar balance, and GLP-1 activity. He also shares practical insights on dosing strategies, including pulse dosing, and how to determine if these advanced tools may fit into your current wellness routine. If you're looking to better understand the connection between cellular health, metabolism, and gut function, this episode offers a thoughtful, research-informed perspective.Products:Buy Fisetin AND Spermadine, get 20% off the sale price! (limited time)Buy 3 or more bottles of GLP-1 Metabolic Optimizer, get $10 off each bottle! (limited time)RegenerLife Sodium Butyrate Postbiotic PacketsJust Ingredients Probiotic Complex - capsulesViRadChem BinderMagnesium BisglycinateAdditional Information:#627: GLP-1 Explained Part 1: How to Support Metabolism Without Drugs#628: GLP-1 Explained Part 2: The Lifestyle Blueprint for Real Metabolic OptimizationVisit the podcast website here: VitalityRadio.comYou can follow @vitalitynutritionbountiful and @vitalityradio on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.

Send us Fan MailWhy are so many people struggling with chronic illness, Lyme symptoms, mold sensitivity, fatigue, and unresolved health issues?In this episode of Never Been Sicker, Michael Rubino sits down with Dr. Bill Rawls, physician, author, and chronic illness expert, to unpack the deeper reasons so many people stay sick.Dr. Rawls shares his own story of health collapse after years of stress and sleep deprivation, why conventional medicine could not fully help him, and how his recovery led him to a completely different understanding of Lyme, mold, microbes, and cellular health.If you've been wondering why symptoms linger, why mold exposure hits some people harder, or why conventional care often falls short with chronic illness, this episode is for you.Subscribe for more conversations on mold, indoor air quality, chronic illness, and the missing links behind modern health.Timestamps00:00 Intro + Dr. Bill Rawls00:33 His health crash + Lyme journey04:03 Herbs + mold exposure06:06 Chronic illness + microbes07:39 Lyme + mold connection08:35 Cellular stress explained11:59 Mitochondria + energy17:28 What is autophagy19:23 What blocks healing24:50 Why he thinks differently30:45 Why chronic illness is rising35:55 Blood pressure example40:07 Biggest lie in medicine42:20 Microbes + chronic disease45:21 5 things to improve health48:58 Homes + environment50:54 How to test your home51:24 Chemicals + modern life56:53 Where to find Dr. Rawls59:27 Outro-----------------------------------------------------------------------------------------------

Fasting reduces inflammation, metabolic syndrome, and visceral fat—what Dr. Goldhamer calls 'a tumor in your abdomen.' #Inflammation #FatLoss #ChronicDisease #HealthTalks

Leslie Kenny was told in her 30s that she had five years to live. Diagnosed simultaneously with lupus, rheumatoid arthritis, and Hashimoto's thyroiditis — and told to give up her dream of having children — she did what true Betties do: she refused the prognosis, threw everything she had at it, and got to work. Now 60 years old, Leslie reports a biological age of 21. She is autoimmune disease-free. And she naturally conceived a child at 43. Her recovery journey led her to collaborate with University of Oxford scientists and to discover spermidine — a naturally occurring, food-derived longevity compound that was hiding in plain sight. It's been in our food for millennia, it's in breast milk, and it's in every plant on earth. And it addresses 9 of the 12 hallmarks of ageing identified by science as the root causes of why we get older. For 20% off Primeadine, go to: https://www.oxfordhealthspan.com/DRSTEPHANIE  Episode Overview (timestamps are approximate): (0:00) Intro/Teaser (4:00) What Is Spermidine and Why Do We Lose It? (8:00) Autophagy, Hair, Nails & the Biological Dashboard (17:00) The 12 Hallmarks of Ageing, Explained for Real Life (23:00) mTOR, Muscle Loss, and Why Spermidine Is Different (27:00) Food Sources, Dosage & Lifestyle Levers (38:00) Leslie's Story: The Diagnosis, the Prognosis, the Refusal (55:00) IVIG, Trauma Therapy & the Surprise Pregnancy at 43 (1:18:00) Femspan, Future Research & Where to Find Leslie (1:22:00) The After-Party Thoughts with Dr. Stephani Resources mentioned in the Episode can be found at: https://drstephanieestima.com/podcasts/ep464  We couldn't do it without our sponsors: JUST THRIVE HEALTH - Take the Just Thrive FEEL BETTER challenge today, and save 20% on your first order. Go to https://justthrivehealth.com/better and use the code BETTER to see the difference for yourself. BON CHARGE - Achieve glowing skin, gain more energy, and uplevel your recovery practice with a suite of red light products. Get 15% off at https://boncharge.com/better with code BETTER. HIGHER DOSE - If you're noticing thinning, shedding, or simply want to support scalp and hair health proactively, this is a powerful addition to your routine. Get 15% off the Red Light Hat at https://higherdose.com with code BETTER at checkout. KENETIK - You think carefully about how you fuel your body but are you fueling your brain? Learn more about Kenetik and try it for yourself by going to https://drinkkenetik.com/BETTER and use code BETTER for 15% off QUALIA LIFE - Boost energy, DNA health, and cellular protection. Save 15% at https://qualialife.com/better with code BETTER. ****************************P.S. When you're ready, here are two ways Dr. Stephanie can help you:Subscribe: The Mini Pause — My weekly newsletter packed with the most actionable, evidence-based tools for women 40+ to thrive in midlife.Build Muscle: LIFT — My progressive strength training program designed for women in midlife. Form-focused, joint-friendly, and built for real results. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Expect a renewed push to take a statin at your next doctor's visit; PREVENT online calculator skews decisions to prescribe cholesterol reduction as early as 30; American Heart Association discourages at-risk patients from taking fish oil and garlic supplements—REALLY? Renewed interest in muscle as promoter of overall health and metabolism; The key role of urolithin A (Mitopure®️) for supporting muscle function. Is DHEA a reasonable supplement for post-menopausal women?

Learn how fasting, senolytics, and supplements like NMN and honokiol help cleanse cells, kill zombie cells, and reverse aging. #Fasting #Senolytics #Supplements #HealthTalks

In this episode, Dr. Jockers dives into the benefits of fasting for 8 hours before bed and how it can trigger fat burning and enhance cellular healing. By reducing insulin levels, your body starts utilizing fat as fuel, unlocking the power of autophagy for deeper detoxification and repair.   You'll discover how this fasting window supports mitochondrial function, improving energy production and brain health. Dr. Jockers explains the key role of healthy mitochondria in fat burning, memory, and overall vitality.   Plus, learn how fasting helps reset your gut microbiome, trimming down harmful bacteria and promoting beneficial ones that improve digestion and immune function. In This Episode:  00:00 Primary and Secondary Feeders 03:15 Eight Hour Fast Overview 03:44 Insulin Drop and Autophagy 05:42 Growth Hormone and Melatonin 08:24 Gut Microbiome Reset 15:54 Meal Prep for the Fast 18:50 Light and Sleep Hygiene 20:20 Exercise and Drink Rules 23:02 Extra Biohacks and Detox 25:52 How Often and Wrap Up   Hair loss isn't just about age—it's about hair follicles getting stuck. AnaGain Nu by Purality Health uses a pea sprout extract clinically shown to reactivate follicles and boost regrowth. With their micelle liposomal delivery, your body absorbs it fast and effectively. Try it risk-free with a 180-day money-back guarantee and get a buy-one-get-one-free deal at RenewYourHair.com -  https://renewyourhair.com/drjm/DRJ.   If you're feeling wired, tired, and depleted, it's time to replenish your electrolytes with Relight from Redmond. Made with Redmond's Real Salt, this clean formula provides essential electrolytes like sodium, potassium, and magnesium without any sugar or artificial ingredients. Perfect for those under stress, fasting, or living an active lifestyle, Relight helps restore hydration, improve energy, and support mental clarity. Visit https://redmond.life/drjockers and use code JOCKERS for 15% off today!   "When insulin drops, your body starts burning fat for fuel—unlocking the healing power of autophagy." ~ Dr. Jockers     Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean TuneIn Radio     Resources:   Reignite hair growth with AnaGain Nu, risk-free with a 180-day guarantee and a buy-one-get-one-free deal!  RenewYourHair.com/drjm/DRJ Visit https://redmond.life/drjockers and use code JOCKERS for 15% off today Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https:/www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/   If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/ 

Episode Overview In the third instalment of our series on famine and revolution, we pull away the veil of headline numbers to investigate the visceral, human reality of the Great Hunger in Ireland. This is an exploration of a land filling with desperation, where the brutal biological mechanics of what happens when the human body begins to consume itself take centre stage. We examine the fate of a terrified people, facing ruin triggered by a disease that wreaked havoc on already weak economies. From the folklore of the Fear Gorta to the harrowing clinical reports of the era, this episode explores how a society is transformed when it is blindsided by biological disaster and administrative indifference. Key Topics Covered: The Information Vacuum: Comparing our modern “Ocean of Information” to the terrifying silence of the 1840s, where the sickly sweet smell of rot was a mystery without an immediate answer. The Folklore of Famine: Why stories like Hansel and Gretel and the Navajo Dine Bahane carry the genetic memory of starvation, and the specific Irish harbinger of death: the Fear Gorta. The Structural Cage: A deep dive into the Rundale system and Gavelkind inheritance. We look at why the West was trapped in a cycle of subdivision while Ulster was shielded by the “Linen Shield” and Tenant Right. The Biology of Starvation: Using modern metabolic science and contemporary medical records to explain the “Blue Nose,” the “Sunken Orbit,” and the terrifying reality of Autophagy—the body cannibalising its own architecture. The Refeeding Trap: The physiological reason why a crust of bread could become a death sentence for a heart shrunken by atrophy. Conspicuous Consumption: The stark contrast between the “Workhouse Swineries” and the elite social calendar, including the dinner menus of the Cork Harbour Regatta. The Gregory Clause: How a single piece of legislation—the Quarter-Acre Clause—was used to engineer the clearances and force the starving into homelessness. The Ledger of the Dead: Analysis of the 1851 Census and the 20–25% demographic erasure that redefined Ireland forever. SOURCES Historical Research & Modern Analysis Delaney, Enda. (2020, December). “‘There But For The Grace of God Go I': Middle-Class Catholic Responses to Ireland's Great Famine.” The English Historical Review, Vol. 135, No. 577, pp. 1433–1460. Donnelly, James S., Jr. (2002). The Great Irish Potato Famine. Stroud: Sutton Publishing. Guinnane, Timothy W. (1994). “The Great Irish Famine and Population: The Long View.” The American Economic Review, Vol. 84, no. 2, pp. 303–08. Ó Gráda, Cormac. (2013, March). “Eating people is wrong: Famine’s darkest secret?” UCD Centre for Economic Research, Working Paper No. WP13/02. O'Riordan, Edmund. (2018, May/June). “‘Every Delicacy of the Season'—Conspicuous Consumption During the Great Hunger.” History Ireland, Vol. 26, No. 3, pp. 26–29. Poirteir, Cathal (Ed.). (1999). The Great Irish Famine. Dublin: Mercier Press. Woodham-Smith, Cecil. (1962). The Great Hunger: Ireland 1845–1849. London: Hamish Hamilton. Guinnane, Timothy W. “The Great Irish Famine and Population: The Long View.” The American Economic Review, vol. 84, no. 2, 1994, pp. 303–08. JSTOR, http://www.jstor.org/stable/2117848. Accessed 31 Mar. 2026 Scientific & Medical Analysis of Starvation Anabtawi, O., & Valente, B. (2025, August 12). “The science of starvation: This is what happens to your body when it's deprived of food.” The Conversation. Donovan, Daniel. (1848). “Observations on the Peculiar Diseases to Which the Famine of Last Year Gave Origin.” Dublin Medical Press. Keys, Ancel, et al. (1950). The Biology of Human Starvation. University of Minnesota Press. (References derived from the Minnesota Starvation Experiment). Primary Documents & Government Records Devon Commission. (1845). Report from Her Majesty’s Commissioners of Inquiry into the State of the Law and Practice in respect to the Occupation of Land in Ireland. Hansard Parliamentary Debates. (1849). HL Deb 15 June 1849 vol 106 cc285-300. (Correspondence of the Earl of Clancarty regarding Ballinasloe). O’Rourke, Canon John. (1875). The History of the Great Irish Famine of 1847. Ridgway, James. (1847). The Irish Relief Measures, Past and Future. Regional Studies & Files Best, Barbara. (2025). “Local Female Orphans and The Earl Grey Scheme 1848-1850.” Tobin, J. “The Famine in Ballyduff and the evictions of Arthur Usher Kiely.” Ballyduff Archive. University College Dublin. (2024). “Hansel and Gretel's famine folklore origins.” The Cambridge Group for the History of Population and Social Structure. Folklore & Cultural Context Dine Bahane. Navajo creation mythology regarding resource scarcity and survival. Fear Gorta (The Hungry Man). Traditional Irish folklore regarding the personification of hunger. Yoruba Mythology. Oral traditions regarding the “Leopards Famine.” The post EP068 WHEN HUNGER WALKS THE LAND appeared first on AGE OF VICTORIA PODCAST.

What if the cancer treatments you trust are built on the wrong foundation?Dr. Thomas Seyfried has spent decades building the scientific case that cancer isn't a genetic disease. It's a metabolic one. And that distinction changes everything. He breaks down exactly why cancer cells can't survive without glucose and glutamine, why conventional oncology has largely ignored this, and why managing cancer without toxic side effects isn't just possible. It's already happening.Dr. Seyfried also explains why eating meat won't raise your glutamine levels the way most people fear, how nutritional ketosis can cut chemotherapy doses in half, and why a drug called DON could be a turning point in metabolic cancer care if the FDA ever gets out of the way. If you or someone you love is navigating a cancer diagnosis, this conversation could reshape how you think about treatment options. Don't wait to hear it.Ready to try fasting but don't want to do it alone? Join Dr. Katie's 3-Day Guided Fast, for expert support, daily live calls, and a community to fast alongside: Sign-Up  Download the FREE Healing Tools Guide: https://bit.ly/drkatie-giftguideMORE FROM KATIE DEMING M.D.6 Pillars of Healing Cancer Workshop Series - Click Here to EnrollTransform your hydration with the Spring Aqua System:  https://springaqua.info/drkatieFollow Dr. Katie Deming on Instagram: https://www.instagram.com/katiedemingmd/Please Support the ShowShare this episode with friends & familyGive a Review on SpotifyGive a Review on Apple PodcastWatch on YoutubeDISCLAIMER: The Born to Heal Podcast  is intended for informational purposes only and is not a substitute for seeking professional medical advice, di...

Heart Association clashes with RFK, Jr., doubles down on recommendation for low-fat diets; Why the evidence for meat and full-fat dairy avoidance is weak; What are the health benefits of circumcision? The ultimate weight loss plan—the Boring Diet; Substituting famotidine for PPIs for reflux; Midlife vitamin D curbs Alzheimer's risk; Natural support for polymyalgia rheumatica; What teens eat could be affecting their mental health.

Send us Fan MailPerimenopause changes how women should fast. In this episode, OWN IT coach Stefanie Billette breaks down a practical rhythm: 15-hour fasts, 17-hour autophagy fasts, and a 24-hour gut reset + when to stop fasting.In this episode, you'll learn:✅ Perimenopause vs. menopause (what's happening + why it can last years)✅ The fasting rhythm: 15h / 17h (autophagy) / 24h (gut reset)✅ When to stop fasting (late-cycle window)✅ 5-1-1 schedule if your cycle is skipping✅ How to break a fast (and what to eat first)===============================================================================About Stefanie Billette Stefanie Billette is an OWN IT Coach, Certified Personal Trainer, and Fitness Nutrition Specialist through the American Council on Exercise. She also holds a B.S. in Psychology and an M.S. in Management.Her background as a K–12 and college educator, along with completing pre-med and pre-nursing programs, cemented her passion for functional nutrition and led her into health coaching. Stefanie began coaching in 2019, helping clients manage chronic symptoms and optimize health. Her personal experience reversing her own autoimmune disease through nutrition and supplements motivates her work daily.She has supported clients with a wide range of conditions, including metabolic disorders, autoimmune diseases, hormone imbalances, and digestive issues.In 2020, Stefanie founded and solely operated an autoimmune-friendly food manufacturing company. She has published numerous articles and books, including:“You Are What You DON'T Eat: How elimination diets saved my son's life, allowed me to reclaim mine, and empowered my daughter to change the course of hers.”A lifelong competitive tennis player and former Zumba instructor, Stefanie balances high-intensity sports with dance, yoga, and pilates. Her coaching approach is nurturing, client-centered, and focused on lifestyle changes that are both attainable and rewarding.Support the show

This episode is brought to you by the⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠Primal Tallow Soaps & Balms.⁠⁠⁠⁠ Is there a single "metabolic switch" that can accelerate weight loss while repairing your cells? In this episode, world-renowned metabolic researcher Dr. Dom D'Agostino (PhD) joins us to explain the science of autophagy, ketosis, and the gut microbiome. Referencing decades of laboratory research and clinical observation, Dr. D'Agostino explains why the traditional "calories in, calories out" model fails to account for cellular signaling and nutrient density. From the specific biochemical benefits of "sardine fasting" to the role of ketones in preserving gut barrier integrity, this conversation provides the medical clarity needed to optimize your biology. Whether you are looking to reverse metabolic dysfunction or seeking the latest data on nutritional ketosis, this episode bridges the gap between science and practical human experience.

RESOURCES- Get my 3 Day Detox here https://danettemay.com/detoxnow- If you want to use the same 5 day fasting program I did, here's the link (you can get a 15% discount if you use my link): https://prolonlife.com/DANETTE - Free of artificial flavors, sugars, and dyes- It's only 5 calories per serving, and every order comes with a 365-day money-back guarantee so you can try it risk-free. Visit nativehydrate.com/DANETTE to see what Native Hydrate could do for your health.CONNECT WITH DANETTEInstagram: @thedanettemayFacebook: Danette MayTikTok: @thedanettemayNEW TV Show on Youtube: @TheDanetteMayListen to The Danette May ShowRead my book: danettemay.com/embraceabundancebookGet The Rise book: therisebook.comWork with Danette: danettemay.comIn this episode, I'm sharing my full 5 day fast experience, walking you through exactly what happened in my body and mind each day. From the initial headaches and hunger waves to entering autophagy and ketosis, I break down the real physical and emotional journey of fasting. If you've ever been curious about the benefits of a 3 day or 5 day fast, including fat loss, detox, cellular renewal, and mental clarity, this episode will give you an honest, behind-the-scenes look at what to expect.But this wasn't just about physical results. This fast became a deeply spiritual experience that helped me reconnect with my body, release old patterns, and gain powerful clarity. I also share how to prepare safely, why your intention matters, and the tools I used to support my body through the process. Whether you're considering fasting for healing, metabolic reset, or spiritual growth, this episode will guide you every step of the way.IN THIS EPISODE:(0:00) Why I did a 5 day fast and what to expect(1:43) My childhood fasting shame and healing my relationship with food(2:44) Detox vs fasting what most people get wrong(3:48) Autophagy ketosis and the spiritual power of fasting(5:43) How to do a 5 day fast safely why I chose ProLon(7:14) Setting your intention why your mindset matters most(10:16) Day one symptoms headaches cravings and low energy(11:38) Day two hunger waves and mental challenges(13:40) Day three breakdown hangry emotions and hardest moment(16:45) Day four breakthrough clarity energy and spiritual connection(18:45) Day five results how to break a fast safely(20:29) My results fat loss healing and what I'll do next(22:11) Final thoughts resources and fasting tips

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Today, I'm joined by Erin Ryan, my producer, for a special follow-up episode where we tackle your most pressing questions about bioregulators and peptides. After the wildly popular Bill Lawrence interview, the Longevity Podcast community sent in a wave of thoughtful queries—from cancer concerns to menopause, sourcing, and practical tips. Click Here for list of BIOREGULATOR NAMES   Books mentioned in this episode: The Peptide Bioregulator Revolution (Great primer on bioregulators) Author: Dr. Marios Kyriazis Peptides and the Epigenetic Control of Aging  (Technical, science-heavy) Author: PhD Vladimir Khavinson, MD, PharmaB Phil Micans, MS, PhD Alexander Maryanovich, MD    Episode Timestamps: Welcome and sponsor introduction ... 00:00:00 Autophagy and Primadene ... 00:00:44 Bioregulator basics and liver support ... 00:01:58 Cancer and telomere lengthening peptides ... 00:05:56 Bioregulators and cancer: caution advised ... 00:08:06 Immune bioregulators and cancer recovery ... 00:12:31 Book reference: "Peptide Bioregulator Revolution" ... 00:13:54 Bioregulators for immune support ... 00:14:44 When not to use bioregulators ... 00:16:56 Menopause, ovarian aging, and bioregulators ... 00:17:47 Clinical outcomes in women ... 00:23:57 GLP-1s and bioregulator absorption ... 00:27:01 Preventative strategies by age ... 00:28:57 Epitalon safety and dosing ... 00:33:18 Bioregulator sourcing and access ... 00:35:41 Amazon caution for supplements ... 00:38:01 Emerging science and trusted brands ... 00:40:03 Social media challenges and newsletter ... 00:44:30   Our Amazing Sponsors: Primeadine by Oxford Healthspan — A food-derived spermidine supplement that supports autophagy and cellular renewal without fasting, made from Japanese wheat germ with clean, rigorously tested ingredients (including a gluten-free option); visit oxfordhealthspan.com/BIONAT20 and use code BIONAT20 at checkout.   Nature's Marvels Bioregulators - provide gentle, organ-specific support — and the Liver Bioregulator is a favorite this season for supporting detox pathways and metabolic flow. Head to profound-health.com and use code NAT15 for 15% off your first order.   http://www.profound-health.com/?Aff=Longevity15   O₃RACLE by Wizard Sciences — A daily ozonated oil capsule designed to support immune balance, cellular communication, and antioxidant production without clinics, machines, or complicated routines; learn more at wizardsciences.com and use code NAT15 for 15% off.   Nat's Links:  YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Dr. Bill Lawrence Episode

Your body already knows how to live to 120 in perfect health. It's just not doing it. That realization is what sent Dr. Chris Rhodes down the fasting research path during his PhD in nutritional biochemistry at UC Davis. His argument? Most people doing 16:8 intermittent fasting aren't getting nearly the benefits they think they are. The body doesn't flip into fasting mode until glycogen stores are depleted, which typically takes 20 to 24 hours. Autophagy, stem cell regeneration, and the real anti-inflammatory benefits don't peak until around 72 hours. In this episode, Dr. Rhodes, creator of Mimio – the world's first fasting mimetic supplement – explains what his team discovered when they tracked metabolites during 36-hour fasts in healthy subjects, as well as how they isolated four synergistic molecules that recreate fasting benefits at the cellular level. We also dig into something personal. Almost a year ago, I started supplementing with Mimio and tracked my biological age using TrueAge epigenetic testing before, during, and after. The result? My pace of aging slowed to 0.85 – meaning that for every calendar year, I'm only aging about 10 months biologically. Rhodes walks me through what the epigenetic markers actually mean, why some of my results seem contradictory on the surface, and why the phenotype matters more than the genotype when it comes to practical health decisions.  We also get into why fasting can disrupt hormonal cycles through caloric restriction signaling, why elite athletes rarely have exceptional longevity despite peak fitness, and why combining actual fasting with Mimio may produce better results than either one alone. Try Mimio and get 20% off your first purchase with code MICHAELKUMMER: https://mimiohealth.sjv.io/qWzkOg  About Chris Rhodes: Dr. Chris Rhodes, PhD, spent 8 years researching fasting at UC Davis before discovering that specific molecules produced during a fast can reduce inflammation, fight oxidative stress, and support metabolic health. That research led him to create Mimio, the world's first fasting mimetic supplement, backed by three clinical studies and designed to deliver measurable longevity benefits without changing your diet or lifestyle. Dr. Chris Rhodes on TikTok: https://www.tiktok.com/@thatnutritiondr Website: https://mimiohealth.com/ Learn more: 73: NAD Supplements That Actually Work: https://www.primalshiftpodcast.com/73-nad-supplements-that-actually-work/ 62: Biological Age Test Review: Epigenetics Explained Simply | Hannah Went: https://www.primalshiftpodcast.com/62-biological-age-test-review-epigenetics-explained-simply-hannah-went/  63: HbA1c Levels Explained: Why They May Be High Without High Blood Sugar: https://www.primalshiftpodcast.com/63-hba1c-levels-explained-why-they-may-be-high-without-high-blood-sugar/  Thank you to this episode's sponsor, Apollo Neuro! Apollo is a wearable that uses gentle sound wave vibrations to signal safety to your nervous system, helping you feel calmer, more focused, and less reactive throughout the day. Check out my full Apollo review: https://michaelkummer.com/health/apollo-neuro-review/ Get $60 off with my discount code PRIMALSHIFT: https://michaelkummer.com/go/apolloneuro In this episode: 00:00 Fasting mimetic breakthrough  02:25 Experiment setup TrueAge  04:13 Why fasting extends life  06:14 How long to fast  09:11 Fasting risks and hormones  13:59 Longevity versus performance  18:02 Mimio [How it works] 20:39 Clinical results and trials  24:17 TrueAge report walkthrough  32:57 Immune markers vs feeling healthy  36:45 Can you change epigenetics  39:45 Pace of aging results  45:04 Hormetic stress and inflammation  50:11 Food and postprandial inflammation  57:05 Wrap up Find me on social media for more health and wellness content: Website: https://michaelkummer.com/ YouTube: https://www.youtube.com/@MichaelKummer Instagram: https://www.instagram.com/primalshiftpodcast/ Pinterest: https://www.pinterest.com/michaelkummer/ Twitter/X: https://twitter.com/mkummer82 Facebook: https://www.facebook.com/realmichaelkummer/ [Medical Disclaimer] The information shared on this video is for educational purposes only, is not a substitute for the advice of medical doctors or registered dietitians (which I am not) and should not be used to prevent, diagnose, or treat any condition. Consult with a physician before starting a fitness regimen, adding supplements to your diet, or making other changes that may affect your medications, treatment plan, or overall health. [Affiliate Disclaimer] I earn affiliate commissions from some of the brands and products I review on this channel. While that doesn't change my editorial integrity, it helps make this channel happen. If you'd like to support me, please use my affiliate links or discount code. #Mimio #Longevity   

Dr. Jerry Mixon on Longevity Medicine: Hormones, Body Fat, Muscle, and Senescent Cells Dr. Jerry Mixon describes “longevity medicine” as treating aging—the progressive loss of capacity—as a medical problem focused on healthspan, not vanity. He shares that at 78 he has maintained a global hormone balance targeted to a healthy 25-year-old range for 31 years, enabling significant strength and endurance gains compared with age 50, and argues more older men should live energetic lives. Mixon emphasizes reducing excess body fat as a priority because fat acts as an inflammatory gland linked to chronic disease, while muscle acts as a healing gland producing beneficial proteins; he advocates building muscle and managing blood sugar/insulin resistance. He explains mitochondrial fragility, senescent “zombie” cells, and immune-system decline, discusses using senolytics such as dasatinib plus quercetin, and describes developing testing to measure senescent T-cell load. The conversation also covers clinic protocols, lifestyle micro-bursts of exercise, family priorities, and aligning healthcare incentives toward prevention. 00:00 Rewriting Old Age 01:46 Longevity Medicine Defined 03:24 Aging as Disease 05:05 How We Peak and Decline 06:15 What Aging Really Is 08:24 From 50 to 78 11:38 Mindset and Metrics 14:52 Start With Getting Lean 17:13 Fat vs Muscle Signals 18:56 Hormones Back to 25 20:26 Testosterone Myths 24:07 Risks and Screening 25:54 Inside the Clinic Process 29:00 Fat Inflammation Cascade 33:20 Insulin Resistance Explained 36:32 GLP-1s and Muscle 37:45 Mitochondria 101 41:14 Senescent Cell Zombies 42:41 Autophagy and Immune Cleanup 44:31 Immune System Senescence 46:10 Hormones and Senescent Load 48:54 Clearing Senescent Cells 50:33 Lifestyle Levers Exercise 53:21 Senolytics and Measuring SASP 56:54 Testing Immune Senescence 58:29 COVID and Aging Immunity 01:01:17 Personal Results and Routine 01:08:26 Family Legacy and Purpose 01:12:54 Reforming Healthcare Incentives 01:19:42 Wrap Up and Disclaimer

Dr. Rhonda Patrick, PhD, is a biomedical scientist and public science educator. She shares the exercise, nutrition, supplementation and lifestyle practices linked to better health and lower disease risk including specific cardio and resistance training routines, when and why to do intermittent fasting, ways to lower visceral fat, omega-3 sourcing, creatine for brain and muscle and peptides such as BPC-157. It's broad and thorough coverage of how to build a total health program tailored to your goals and individual biology. Read the show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Our Place: https://fromourplace.com/huberman Lingo: https://hellolingo.com/huberman LMNT: https://drinklmnt.com/huberman Function: https://functionhealth.com/huberman Mateina: https://drinkmateina.com/huberman Timestamps 00:00:00 Rhonda Patrick (00:02:40) Competition, Jumping Rope, Rope Flow (00:06:49) Rhonda's Exercise Routine, Cardiovascular & Resistance Training (00:12:30) Cognitive & Physical Benefits of Exercise, Serotonin & Impulse Control (00:14:40) Sponsors: Our Place & Lingo (00:17:03) Phones While Training? (00:18:45) Rhonda's Strength Training, Low-Reps, Modifications, Mental Resilience (00:27:00) Daily Protein Intake, Intermittent Fasting, Processed Carbohydrates (00:33:32) Lipopolysaccharide (LPS); Gut Permeability, Gluten; Cardiovascular Health (00:42:58) Sponsor: AG1 (00:44:21) Tight Junctions, Gut, Neuroinflammation (00:47:26) L-glutamine, Immune System, Cancer Risk (00:54:55) N-acetylcysteine (NAC), Vitamin E; Antioxidant Balance, Reductive Stress (01:00:08) Starch, Tool: Bedtime Fast & Cardiovascular Health (01:03:36) Cortisol, Intermittent Fasting Benefits (01:08:09) Cortisol, Train Fasted?; Hormones, Visceral Fat (01:13:35) Visceral Fat, Perimenopause/Menopause, Insulin Resistance in Brain & Body (01:21:13) Sponsor: LMNT (01:22:33) Cortisol & Sleep (01:25:42) Intermittent Fasting, Metabolic Switch, Ketones, Muscle Loss? (01:36:47) Tools: Logic-Based Habits; Daily Metabolic Switch; Exercise, Autophagy (01:45:06) Exercise After Poor Sleep?; Training Breaks (01:52:47) Tool: "Exercise Snacks"; Sedentary Lifestyle & Cardiorespiratory Fitness (02:03:31) Sponsor: Function (02:05:16) Creatine, Dose, Resistance Training, Cognitive Function (02:17:43) Biology; Creatine; Supplement Safety (02:25:18) Omega-3s, Inflammation, Cancer Risk, Vitamin D; Trans Fat (02:36:52) Magnesium Threonate vs Bisglycinate, Sleep, Cognitive Benefit; Vitamin D (02:45:46) Supplement Types, Multivitamin, Coenzyme Q10, Urolithin A, Sulforaphane (02:55:10) Microplastics (02:57:26) Sponsor: Mateina (02:58:28) BPC-157, NMN, NR, Tool: Evaluating Supplements, Safety, Sources (03:06:28) L-Carnitine, Alpha-GPC, Nicotine, GABA & Ketogenic Diet (03:15:20) Nattokinase; Microplastics, Water Bottles; Seed Oils (03:22:21) Sauna, Creatine for Kids?, Bananas, Tool: Evaluating Studies (03:28:37) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode, Dr. David Jockers dives into the seven most common fasting mistakes that can hinder autophagy and fat burning. He explains how improper fasting can leave you feeling fatigued and disrupt your body's natural fat-burning process. Dr. Jockers provides actionable tips on how to fix these mistakes and maximize the benefits of fasting.   You'll learn why protein and healthy fats are crucial for stabilizing blood sugar and reducing cravings during your eating window. Dr. Jockers also highlights how these factors support sustained energy levels and make fasting more effective.   Additionally, Dr. Jockers discusses the impact of stress, sleep, and electrolytes on your fasting experience. Understanding how these elements interact will help you fine-tune your fasting routine for optimal results and improved overall well-being. In This Episode:  00:00 Fasting Drinks Rules 00:27 Podcast Intro Autophagy mTOR 03:11 Seven Fasting Mistakes 05:07 Fix Meals Macros 07:12 Stress Sleep Electrolytes 12:05 Stevia Caffeine Cortisol 14:34 Constipation Hydration Magnesium 15:31 Women Cycle Fasting Timing 17:31 Exercise Timing Autophagy 18:30 Wrap Up And Outro     If you want to burn belly fat…boost your energy levels…balance blood sugar…or relieve swelling in your legs or feet… Then you need to check out PureHealth Research immediately.   This company makes some amazing health-boosting supplements that are manufactured right here in America. They only use natural, non-GMO ingredients that are backed by the latest science and proven to work.   And right now, you can save 35% on all of their products with this special subscriber-only offer. Just use your exclusive coupon code JOCKERS at checkout.   This episode is brought to you by Armra Colostrum. Boost your gut health, immune system, and skin with nature's first whole food, packed with over 400 bioactive nutrients. Armra Colostrum helps support gut integrity, immune health, and overall vitality. Right now, you can get 30% off your first subscription order by using the promo code JOCKERS at checkout. Don't miss out—head to armra.com/drjockers to claim your offer today!     "Consuming 30-50 grams of protein per meal is key to stabilizing blood sugar and keeping cravings at bay."  ~ Dr. Jockers     Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean TuneIn Radio     Resources: Visit http://armra.com/drjockers Visit https://www.purehealthresearch.com/ - Use code DRJOCKERS for 35%     Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https://www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/ If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/ 

Today, I'm joined by the inspiring Leslie Kenny, Oxford-based longevity expert and a living example of turning adversity into vitality. After being told at 39 that she had lupus, rheumatoid arthritis, and just five years to live, Leslie defiantly forged a new path—reversing her diagnoses, restoring her thyroid health, and even welcoming a healthy baby girl at 43. Her story is a testament to the power of questioning the status quo, honoring the wisdom within our bodies, and refusing to accept decline as inevitable.   Leslie has a generous offer for you, when you visit oxfordhealthspan.com/BIONAT20 and use code BIONAT20 at checkout you'll get 20% off.   Episode Timestamps: Welcome, show intro, and overview ... 00:00:00 Leslie Kenny's health journey and reversing disease ... 00:00:30 Biological vs. chronological age and the immune system ... 00:04:55 Impact of trauma and stress on aging ... 00:11:51 Overcoming prognosis: lifestyle and scientific interventions ... 00:18:02 Diet, tracking, and removing triggers ... 00:22:21 The overlooked importance of thyroid health ... 00:32:23 Dangers of overdoing fasting and hormesis ... 00:40:21 Autophagy basics and the cellular cleanup crew ... 00:44:06 Spermidine's role, sourcing, and supplement quality ... 01:10:19  Optimizing longevity habits and daily routines ... 01:29:44   Our Amazing Sponsors: Tro Zzz by Troscriptions – A fast-acting sleep troche that dissolves in your cheek and combines melatonin with compounds like honokiol, adenosine, cordycepin, CBD, CBN, and 5-HTP to support deep, restorative sleep when travel, stress, or late workouts throw things off. Head to troscriptions.com and use code NAT10 for 10% off your first order.    BEAM Minerals - Low energy often starts in the mitochondria. Support cellular energy with a bioavailable liquid mineral supplement — and get 20% off at beamminerals.com with code NAT20. Nature's Marvels Bioregulators - provide gentle, organ-specific support — and the Liver Bioregulator is a favorite this season for supporting detox pathways and metabolic flow. Head to http://www.profound-health.com/?Aff=Longevity15 and use code NAT15 for 15% off your first order.   Nat's Links:  YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Dr. Bill Lawrence Episode

Is fasting actually worth it for fat loss, muscle retention, and longevity? In this science-backed breakdown, I explain intermittent fasting, autophagy, AMPK, mTOR, and whether fasting helps or hurts muscle growth. ► Free 7 Day Trial To My Workout App: https://www.liveleantv.com ► Live Lean Body Quiz: https://www.liveleantv.com/quiz ► Free 7 Day Meal Plan And Recipes: https://www.liveleantv.com/free-stuff

The MAHA backlash over RFK Jr.'s about-face on glyphosate; Amid the partisan divide, Making America Healthy Again cuts across party lines; New study confirms effectiveness of personalized lifestyle interventions for reversing dementia; After an allergic reaction to the Covid shot, is it safe to take other vaccines? Some GLP-1 users are developing scurvy; Six lifestyle hacks that augment weight loss drugs' cardio benefits.

Want to lose your next 3–5 lbs the sustainable way? Join my free 6-day email series where I break down exactly how to structure your workouts, nutrition, and habits if you are a plant-based eater over 50.

Is what I've been doing for years helpful for achieving autophagy?When you say low carb, do you mean low complex carb or low simple and processed carb?What daily multivitamin would you recommend for a male age 50 plus?Which supplement should I take for elevated triglycerides?

Integrative Healthcare Symposium highlightsWhat supplements can help combat the side effects of cancer therapy?Will my son's use of Zepbound affect his fertility?

RESOURCES- Join me in Lotus Rising Premium Coaching at danettecoaching.com - If you want to use the same 5 day fasting program I did, here's the link (you can get a 15% discount if you use my link): https://prolonlife.com/DANETTE - Fuel your day with Rootz Nutrition Protein Superfood: a clean protein plus greens blend designed to support energy, curb cravings, and nourish your body with real superfoods.Click this link to get your exclusive discount and try it for yourself.CONNECT WITH DANETTEInstagram: @thedanettemayFacebook: Danette MayTikTok: @thedanettemayNEW TV Show on Youtube: @TheDanetteMayListen to The Danette May ShowRead my book: danettemay.com/embraceabundancebookGet The Rise book: therisebook.comWork with Danette: danettemay.comIn this final episode of the Diary Series, I share my full 5 day fast results and what truly happened during my extended fasting experience. What began as a 5 day fast for autophagy, caffeine detox, and nervous system healing became a powerful emotional and spiritual reset. I walk through the physical symptoms, ketosis, hanger moments, and the unexpected clarity that emerged by day four and five. If you are curious about extended fasting for women, the benefits of autophagy, or what actually happens during a 5 day fast, this episode offers a transparent and personal breakdown.I also share how to break a fast safely after 5 days, what I ate first, and why proper refeeding matters for metabolism and hormonal balance. Beyond the physical benefits of fasting, this conversation explores emotional detox, spiritual connection, and the clarity that can come from clearing the body and calming the nervous system. If you are considering a 5 day fast or looking for a reset in your health and energy, this episode will give you real insight into the process and the transformation that followed. IN THIS EPISODE:(0:48) My final day check in and how you can support the show(1:34) What is coming next in 2026 astrology, grief, and powerful conversations(2:24) My go to superfood shake for busy healing days(3:43) I completed a 5 day fast and here is why I did it(4:51) Day 3 was the hardest hunger, emotions, and ketosis breath(6:28) Day 4 everything shifted tears, ritual, and deep spiritual clarity(8:04) Day 5 connection gratitude, intuition, and feeling my loved ones near(8:40) How I fasted safely, autophagy, and what you should know(11:37) How I broke my 5 day fast safely and what I ate...

RESOURCES- Our winner for the $150 Visa Gift Card is Dorothy Zimmers! We will contact you in order to receive the gift.- Get my 3 Day Detox here https://danettemay.com/detoxnow- If you want to use the same 5 day fasting program I did, here's the link (you can get a 15% discount if you use my link): https://prolonlife.com/DANETTE - Struggling with hair shedding or slow growth? Try Liposomal Hair Renewal with AnaGain Nu for fuller, healthier-looking hair. Exclusive offer for The Danette May Show listeners at renewyourhair.com/danettemayDewskin Instagram:https://www.instagram.com/dewskindenverDewskin Website: https://dewskindenver.com/Dewskin Shopify Product Store:https://dewskin.shopCONNECT WITH DANETTEInstagram: @thedanettemayFacebook: Danette MayTikTok: @thedanettemayNEW TV Show on Youtube: @TheDanetteMayListen to The Danette May ShowRead my book: danettemay.com/embraceabundancebookGet The Rise book: therisebook.comWork with Danette: danettemay.comIn Day 6 of my diary series, I share what it has been like to step into a 5 day fast for autophagy and cellular renewal while quitting coffee and moving through a glutathione facial peel during a time of deep personal and collective change. After two recent shootings in my small mountain town, one at the local high school and another at the rec center, I felt called inward. In this episode, I open up about my childhood experience with Mormon fasting, the shame I carried around breaking a fast, and why I avoided fasting for years even though I understood the health benefits of detox, prayer, and intentional restriction.I also talk about how I am supporting my body safely with electrolytes, minerals, and a low calorie approach to help stimulate autophagy, along with what I am noticing from caffeine withdrawal, energy shifts, and sleep changes. More than anything, this episode is about nervous system regulation, spiritual fasting, resilience after trauma, and choosing love when the world feels upside down. If you are walking through your own healing journey, detox, spiritual reset, or simply

Reflections on the Peter Attia/Epstein scandal; How to lower lp(a)—does diet help? What are bio-active peptides? Could they stave off kidney disease? Scientists just tested the fittest 81-year-old in the world—here's what they found; Media erroneously report that intermittent fasting is not effective for weight loss; Sugary drinks may stoke anxiety in teens; Omega-3s support kids' reading fluency and spelling scores; Surprising study shows saturated fats not harmful to kidneys.

(Originally recorded July 28, 2024 for another podcast Corinna once hosted, Nutrition Without Compromise — shared with permission.) Aging is often framed as inevitable decline. But what if much of what we call “aging” is actually preventable disease accumulation? In this essential re-release episode, Corinna Bellizzi sits down with Michael Greger, physician, internationally recognized speaker, and founder of NutritionFacts.org. Dr. Greger's latest book, How Not to Age, builds on the groundbreaking work of How Not to Die and How Not to Diet — translating peer-reviewed science into practical guidance for living longer and healthier. In this conversation, we explore: The difference between lifespan and healthspan Why excess protein may accelerate aging pathways The myth of “incomplete” plant proteins Fish consumption, pollution, and algae-based Omega-3 alternatives Autophagy, spermidine, and cellular repair The role of vitamin B12, vitamin D, and DHA The promise of lifestyle medicine in addressing Alzheimer's and chronic disease This episode launches a curated Care More Be Better re-share series highlighting foundational health conversations that remain deeply relevant today. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

This week on The Audit Podcast, our guest is William Englehaupt, CEO and founder of Autophagy and former director at KPMG.   Bill shares his perspective on bringing discipline, structure, and consistency to audits by applying Lean and Six Sigma principles to the audit process. Drawing on his experience working with hundreds of audit teams across large public accounting firms, he explains why audits should be treated as standard work and how reducing variation in execution can dramatically improve outcomes for both auditors and clients.   We talk about innovative audit methods, real-world client success stories, and why managing audits with urgency and control matters more than relying on theory or hoping things come together. Bill also walks through key ideas from his book, Managing the Hell Out of Your Audit, including the importance of upfront coaching and certifying staff before work begins to reduce rework, review notes, and frustration across audit teams Be sure to connect with Bill on LinkedIn.   Also, be sure to follow us on our social media accounts on LinkedIn, Instagram, and TikTok.   Also be sure to sign up for The Audit Podcast newsletter and to check the full video interview on The Audit Podcast YouTube channel.   Timecodes:   2:52 - Bills BBQ 6:37 - A Favorite AI Prompt 9:45 -  Innovative Approaches to Auditing 11:10 - Client Success Stories 16:53 - Bringing Discipline to New Methodologies 20:13 - Managing the Hell Out of Your Audit 23:08 - The Value of Upfront Coaching 26:40 - Final Thoughts   This podcast is brought to you by Greenskies Analytics, the services firm that helps auditors leap-frog up the analytics maturity model. Their approach for launching audit analytics programs with a series of proven quick-win analytics will guarantee the results worthy of the analytics hype.  Whether your audit team needs a data strategy, methodology, governance, literacy, or anything else related to audit and analytics, schedule time with Greenskies Analytics.

Why is it that we chase longevity like it's a number, yet ignore the daily behaviors that are aging us from the inside out?Most of us think longevity is about adding years. But what if it's really about removing what no longer serves you at the cellular level and at the identity level?Renee Fitton — registered dietitian, longevity specialist, and one of the leading voices in fasting-mimicking science (VP at Prolon) — breaks down the biology of renewal… and the psychology that quietly shapes our habits.Show Partners:Get your MENTAL FITNESS BLUEPRINT here! A special thanks to our mental fitness + sweat partner Sip SaunasPersonal Socrates: Better Question, Better LifeConnect with Marc: https://konect.to/marcchampagneTimestamps:00:00 — The question that opens every interview: “Who are you?”03:00 — Perfectionism, ambition, and living in the imperfect07:00 — Personality tests, self-work, and using tools like ChatGPT for reflection11:00 — Preparing for the Hoffman Process: deep psychological self-work15:00 — How to prepare your body for intense personal growth16:00 — Alcohol, sleep, and energy management before a retreat18:00 — Why plant-based nutrition supports repair and rejuvenation21:00 — Growth mode vs repair mode: the biology behind it23:00 — Autophagy explained: your body's cellular vacuum cleaner25:00 — What is the fasting mimicking diet?29:00 — Why prolonged fasting (3+ days) activates deep repair31:00 — The mental shifts that happen during fasting33:00 — Behavior change, food psychology, and identity34:00 — Type 2 diabetes study: self-initiated behavior transformation37:00 — Why five days can change your long-term habits39:00 — Why water-only fasting feels harder41:00 — How often should you fast for longevity?44:00 — Gratitude journaling as a daily mental fitness tool46:00 — The power of daily movement for emotional regulation47:00 — Renewal at the cellular and personal level*Special props

In this episode, Dr. David Jockers dives into the benefits of the Protein Sparing Modified Fast, a powerful tool for burning fat, especially visceral fat. He explains how this strategy promotes fat loss while preserving lean muscle mass, even with a calorie-restricted diet.   Dr. Jockers shares how fasting triggers autophagy and the role it plays in cellular rejuvenation, helping the body break down old, damaged mitochondria and replace them with healthier ones.   He also discusses how protein-sparing fasting impacts insulin sensitivity, brain function, and overall resilience, while offering practical tips for implementing this approach into your lifestyle.   In This Episode:  00:00 Introduction to Fasting and Its Historical Context 00:48 Protein Sparing Modified Fast Explained 06:57 Dr. Jockers' Journey into Holistic Health 12:45 Introduction to Fasting Practices 14:20 Personal Fasting Experience and Benefits 17:32 Intermittent Fasting and Its Popularization 27:20 Autophagy and Cellular Rejuvenation 36:21 Challenges of Extended Fasting 37:13 Introduction to Protein Sparing Modified Fast 37:54 Benefits and Guidelines of Protein Sparing Modified Fast 40:35 Practical Tips for Protein Sparing Modified Fast 45:15 Addressing Common Concerns About Fasting 48:53 The Role of Ketones in Brain Health 54:42 Spiritual and Physical Benefits of Fasting 56:42 Autophagy and Protein Sparing Modified Fast 01:03:33 Tips for Enhancing Insulin Sensitivity 01:06:20 Favorite Meals and Desserts 01:08:31 Concluding Thoughts and Favorite Bible Verse   If you want practical, natural strategies to balance your hormones, heal your gut, boost your energy, and slow aging, don't miss The Dr. Josh Axe Show. Dr. Axe blends ancient wisdom with cutting-edge science and brings on world-class experts for unfiltered conversations you won't hear anywhere else. Transform your health from the inside out and subscribe to The Dr. Josh Axe Show, with new episodes every Monday and Thursday.   If you're looking to boost your health naturally, Paleo Valley's Super Greens powder is a game-changer. Packed with 23 organic superfoods, it provides all the nutrients your body needs for boundless energy and vitality, without the digestive issues that come with cereal grasses. For 15% off, visit paleovalley.com/jockers and use code JOCKERS at checkout.   When it comes to cooking, Chef Foundry offers the perfect solution with their P 600 ceramic cookware, which is free from Teflon, PFAS, and plastic coatings. Made with Swiss-engineered ceramic, this cookware makes it easy to prepare healthy meals without the toxins. Take 20% off with code SAFE20 at chefsfoundry.com/jockers and upgrade your kitchen today.     "Protein Sparing Modified Fast helps quench satiety, and most people on it don't feel as hungry or have cravings."      Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean TuneIn Radio   Resources: Visit paleovalley.com/jockers for 15% off with code JOCKERS. Visit chefsfoundry.com/jockers for 20% off with code SAFE20. Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https://www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/ If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/ 

Is mitochondrial decline the hidden blueprint that decides how fast your body ages?Josh Trent welcomes Dr. Brad Currier, PhD, Clinical Scientist, to the Wellness + Wisdom Podcast, episode 793, to unpack how mitochondrial health is passed through generations, why modern environments and sedentary living accelerate aging, how mitophagy and Urolithin A restore cellular energy, why gut health blocks or enables longevity, and how exercise plus targeted supplementation can fundamentally shift mood, vitality, and long term health from the inside out.30% Off Mitopure (Timeline Nutrition): The first clinically tested Urolithin A supplementMitopure® is a highly pure form of Urolithin A, a postbiotic clinically shown to energize cells, increase muscle strength, and improve endurance. And this is just the beginning. New studies continuously explore and prove the incredible potential of Urolithin A.Few people can get enough Urolithin A from diet alone. Mitopure unlocks 6X the dose of Urolithin A when compared to dietary sources such as pomegranate juice, without the sugar.Get Mitopure Today + Save 30% with code JOSH at checkoutIn This Episode, Dr. Brad Currier Uncovers:(01:12) Why mitochondria are inherited from your biological mother(02:31) Mitochondria explained like you're 10(03:37) What silently drains mitochondrial power(05:31) UV, pollution, toxins(08:36) The “seventh generation” lens(13:29) Why cells age before we “feel” old(17:31) Autophagy vs mitophagy(20:12) Urolithin A + the microbiome(32:33) Mitopure vs NAD/CoQ10(50:20) The Fundamentals of Health

Most conversations about longevity focus on tactics. This episode breaks down the biology underneath them. You'll hear a systems level analysis of how insulin signaling, mTOR, mitochondrial function, inflammation, and nutrient sensing interact to determine biological age, disease risk, and long term human performance. This is not surface level biohacking. It is a deep dive into the mechanisms that actually control aging, metabolism, muscle preservation, and brain optimization, and why most anti aging strategies fail when they ignore these foundations. This all-time classic episode from 2024, has host Dave Asprey joined by Mark Hyman, a practicing physician and one of the most respected leaders in functional medicine. Dr. Hyman is the founder and senior advisor of The UltraWellnessCenter, the founder and former head of strategy and innovation at the Cleveland Clinic Center for Functional Medicine, and a long time advocate for treating root causes instead of managing disease. With over 30 years of clinical experience, his work focuses on restoring mitochondrial health, optimizing metabolism, reversing chronic disease, and slowing biological aging using science backed interventions. Together, Dave and Mark dismantle common myths around protein, carnivore diets, ketosis, fasting, supplements, and longevity drugs. They explain why sugar accelerates aging faster than protein, how mTOR must cycle instead of staying suppressed, and why muscle, mitochondria, and metabolic flexibility matter more than calorie restriction. The conversation also covers nootropics, sleep optimization, neuroplasticity, AI driven diagnostics, and how functional medicine reframes aging as a reversible biological process rather than an inevitable decline. You'll learn: • How insulin and nutrient sensing control aging speed • Why mitochondria sit at the center of longevity and disease • The truth about mTOR, fasting, and protein intake • How ketosis and metabolic flexibility protect long term health • Where supplements and nootropics actually fit in brain optimization • Why functional medicine outperforms symptom based care • How AI and advanced testing are reshaping modern medicine Thank you to our sponsors! - MASA Chips | Go to https://www.masachips.com/DAVEASPREY and use code DAVEASPREY for 25% off your first order. -ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order. -OneSkin | Try OneSkin for 15% off with code DAVE at https://www.oneskin.co/DAVE. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: longevity biohacking, functional medicine longevity, biological age reversal, mitochondria and aging, mTOR pathway aging, insulin resistance and aging, metabolic flexibility, fasting and longevity, ketosis and metabolism, protein intake and mTOR, muscle and longevity, inflammaging, chronic inflammation aging, mitochondrial dysfunction, nutrient sensing pathways, rapamycin longevity, metformin longevity debate, carnivore diet longevity, sugar and aging, brain optimization longevity, neuroplasticity and aging, sleep optimization biohacking, supplements for longevity, anti aging metabolism, human performance optimization, Dave Asprey longevity, Mark Hyman longevity Resources: • Mark's Website: https://drhyman.com/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 - Trailer 0:45 - Introduction 4:49 - Aging as a Treatable Disease 7:50 - The Hallmarks of Aging 14:23 - Nutrient Sensing and Longevity Switches 17:37 - Time Restricted Eating and Autophagy 20:44 - The Four Longevity Pathways 21:49 - Metformin Debate 25:30 - Ozempic and Weight Loss 28:42 - Rapamycin and mTOR 36:23 - Meat, Protein, and Aging 39:46 - Protein Quality and Muscle Synthesis 45:50 - Protein Timing for Muscle Building 48:08 - Metabolic Flexibility 51:32 - Inflammaging 55:26 - Zombie Cells and Senescence See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What if the confusion around fasting and hormones isn't because the science is complicated, but because most people are using the wrong tools for the wrong goals? In this episode, I sit down with Dr. Mindy Pelz to get clear about what fasting actually does, when it helps, and when it backfires. This is a conversation about taking ownership of your metabolism instead of chasing trends that don't match your life. We talk about the viral moment from her Stephen Bartlett interview, how misinformation spreads, and what she learned from being at the center of it. Mindy breaks down her six core fasts, why women need a different strategy, and how to adjust your approach if you train hard. We get into cycle-based fasting, fertility, menopause, HRT, toxic load, peptides, creatine, apple cider vinegar, and the rise of GLP-1 drugs. If you've ever wondered how to use fasting without wrecking your energy or performance, this episode will give you a clearer path forward. Dr. Mindy Pelz is a bestselling author, educator, and functional health expert known as the fasting guru. Her books Fast Like a Girl and Age Like a Girl have helped millions of women rethink metabolic health, hormones, and aging, and she has led hundreds of thousands of people through community fasts that focus on real-world results, not quick fixes. What We Discuss: (00:00) How a Misquote Went Viral and Changed Mindy's Career (04:12) What the Internet Got Wrong About Testosterone and Fasting (11:19) The Biggest Fasting Mistakes Most People Still Make (17:05) The Six Core Types of Fasting and When to Use Each (23:28) Fasting for Gut Repair, Weight Loss, and Dopamine Reset (28:54) How Athletes and Active Women Should Adapt Their Fasts (34:04) Cycle-Based Fasting and Hormonal Timing for Women (43:00) Supplement Cycling, Autophagy, and Metabolic Flexibility (55:19) GLP-1 Drugs, Gut Health, and the Real Drivers of Hunger (59:31) The Long-Term Risks of Quick-Fix Weight Loss Trends (01:05:40) Fertility, Progesterone Needs, and Rethinking HRT (01:16:14) Menopause, Brain Rewiring, and Building Cognitive Strength (01:28:48) Peptides, ACV, and Final Insights Before Wrap-Up Thank you to our sponsors: Therasage: Head over to therasage.com and use code Be Bold for 15% off Air Doctor: Go to airdoctorpro.com and use promo code HUSTLE40 for up to $300 off and a 3-year warranty on air purifiers. Magic Mind: Head over to www.magicmind.com/jen and use code Jen at checkout. Momentous: Shop this link and use code Jen for 20% off Manna Vitality: Visit mannavitality.com and use code JENNIFER20 for 20% off your order Prolon: Get 30% off sitewide plus a $40 bonus gift when you subscribe to their 5-Day Program! Just visit https://prolonlife.com/JENNIFERCOHEN and use code JENNIFERCOHEN to claim your discount and your bonus gift. Amp fit is the perfect balance of tech and training, designed for people who do it all and still want to feel strong doing it. Check it out at joinamp.com/jen Find more from Jen:  Website: www.jennifercohen.com Instagram: @therealjencohen   Books: www.jennifercohen.com/books Speaking: www.jennifercohen.com/speaking-engagement Find more from Dr. Mindy Pelz: Website: www.drmindypelz.com Instagram: @dr.mindypelz TikTok: @drmindypelz YouTube: @drmindypelz