Podcasts about Autophagy

Cellular catabolic process in which cells digest parts of their own cytoplasm

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Autophagy

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Best podcasts about Autophagy

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Latest podcast episodes about Autophagy

The Tutor Podcast
The Fasting Miracle

The Tutor Podcast

Play Episode Listen Later Dec 29, 2025 26:23


Neil steps away from traditional business tactics to focus on the essential foundation of any successful venture: the health and well-being of the entrepreneur. He explores the concept of ‘The Fasting Miracle', specifically focusing on water fasting and its transformative effects on the body and mind. He breaks down the biological processes that occur during various stages of fasting, from the initial fed state to deep cellular repair and regeneration. By sharing his personal 21-day fasting experience and detailing the scientifically supported benefits, such as increased mental clarity, fat loss, and immune system rebooting, Neil provides a compelling case for fasting as a no-cost tool for tutors and coaches to optimise their performance and longevity. KEY TAKEAWAYS Maintaining good health is a critical business issue because it forms the foundation for everything a business owner does. Fasting triggers natural mechanisms like lipolysis (fat burning) and ketosis, where the body switches from burning glucose to burning stored fat and ketones for cleaner, steadier energy. Between 20 to 24 hours of fasting, the body initiates autophagy - a "self-eating" process where damaged cells and proteins are recycled into useful materials, reducing inflammation and the risk of degenerative diseases. Extended fasting (72+ hours) can eliminate old white blood cells and stimulate stem cell production to create a new, more efficient immune system. BEST MOMENTS "Health is the foundation on which everything we do is built. So staying healthy is a business issue." "Fasting isn't some brand new trendy fufu-dufu woo-woo fad. People have been doing it for centuries." "Autophagy is cellular cleanup and repair. The damaged proteins and organelles that are flapping around your body are broken down and recycled into useful stuff." "BDNF supports brain health and cognitive function. I've heard BDNF often called miracle grow for the brain, and that's what it does." "The longer I fasted, the better I felt. My mental sharpness increased like it's hard to explain. I just got sharper, faster." VALUABLE RESOURCES www.Neilcowmeadow.com info@neilcowmeadow.com HOST BIO Neil Cowmeadow is a maverick peripatetic guitar teacher from Telford with over 19 years' experience in the business of helping people. Learn how to start, grow and love your business with Neil's invaluable advice and tips without the buzzwords and BS! This Podcast has been brought to you by Disruptive Media. https://disruptivemedia.co.uk/

The Human Upgrade with Dave Asprey
What it takes to be “Young Forever!” | Mark Hyman : 1385

The Human Upgrade with Dave Asprey

Play Episode Listen Later Dec 23, 2025 62:30


Most conversations about longevity focus on tactics. This episode breaks down the biology underneath them. You'll hear a systems level analysis of how insulin signaling, mTOR, mitochondrial function, inflammation, and nutrient sensing interact to determine biological age, disease risk, and long term human performance. This is not surface level biohacking. It is a deep dive into the mechanisms that actually control aging, metabolism, muscle preservation, and brain optimization, and why most anti aging strategies fail when they ignore these foundations. This all-time classic episode from 2024, has host Dave Asprey joined by Mark Hyman, a practicing physician and one of the most respected leaders in functional medicine. Dr. Hyman is the founder and senior advisor of The UltraWellnessCenter, the founder and former head of strategy and innovation at the Cleveland Clinic Center for Functional Medicine, and a long time advocate for treating root causes instead of managing disease. With over 30 years of clinical experience, his work focuses on restoring mitochondrial health, optimizing metabolism, reversing chronic disease, and slowing biological aging using science backed interventions. Together, Dave and Mark dismantle common myths around protein, carnivore diets, ketosis, fasting, supplements, and longevity drugs. They explain why sugar accelerates aging faster than protein, how mTOR must cycle instead of staying suppressed, and why muscle, mitochondria, and metabolic flexibility matter more than calorie restriction. The conversation also covers nootropics, sleep optimization, neuroplasticity, AI driven diagnostics, and how functional medicine reframes aging as a reversible biological process rather than an inevitable decline. You'll learn: • How insulin and nutrient sensing control aging speed • Why mitochondria sit at the center of longevity and disease • The truth about mTOR, fasting, and protein intake • How ketosis and metabolic flexibility protect long term health • Where supplements and nootropics actually fit in brain optimization • Why functional medicine outperforms symptom based care • How AI and advanced testing are reshaping modern medicine Thank you to our sponsors! - MASA Chips | Go to https://www.masachips.com/DAVEASPREY and use code DAVEASPREY for 25% off your first order. -ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order. -OneSkin | Try OneSkin for 15% off with code DAVE at https://www.oneskin.co/DAVE. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: longevity biohacking, functional medicine longevity, biological age reversal, mitochondria and aging, mTOR pathway aging, insulin resistance and aging, metabolic flexibility, fasting and longevity, ketosis and metabolism, protein intake and mTOR, muscle and longevity, inflammaging, chronic inflammation aging, mitochondrial dysfunction, nutrient sensing pathways, rapamycin longevity, metformin longevity debate, carnivore diet longevity, sugar and aging, brain optimization longevity, neuroplasticity and aging, sleep optimization biohacking, supplements for longevity, anti aging metabolism, human performance optimization, Dave Asprey longevity, Mark Hyman longevity Resources: • Mark's Website: https://drhyman.com/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 - Trailer 0:45 - Introduction 4:49 - Aging as a Treatable Disease 7:50 - The Hallmarks of Aging 14:23 - Nutrient Sensing and Longevity Switches 17:37 - Time Restricted Eating and Autophagy 20:44 - The Four Longevity Pathways 21:49 - Metformin Debate 25:30 - Ozempic and Weight Loss 28:42 - Rapamycin and mTOR 36:23 - Meat, Protein, and Aging 39:46 - Protein Quality and Muscle Synthesis 45:50 - Protein Timing for Muscle Building 48:08 - Metabolic Flexibility 51:32 - Inflammaging 55:26 - Zombie Cells and Senescence See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Habits and Hustle
Episode 511: Dr. Mindy Pelz: Fix Your Metabolism with the Right Type of Fast

Habits and Hustle

Play Episode Listen Later Dec 16, 2025 88:30


What if the confusion around fasting and hormones isn't because the science is complicated, but because most people are using the wrong tools for the wrong goals? In this episode, I sit down with Dr. Mindy Pelz to get clear about what fasting actually does, when it helps, and when it backfires. This is a conversation about taking ownership of your metabolism instead of chasing trends that don't match your life. We talk about the viral moment from her Stephen Bartlett interview, how misinformation spreads, and what she learned from being at the center of it. Mindy breaks down her six core fasts, why women need a different strategy, and how to adjust your approach if you train hard. We get into cycle-based fasting, fertility, menopause, HRT, toxic load, peptides, creatine, apple cider vinegar, and the rise of GLP-1 drugs. If you've ever wondered how to use fasting without wrecking your energy or performance, this episode will give you a clearer path forward. Dr. Mindy Pelz is a bestselling author, educator, and functional health expert known as the fasting guru. Her books Fast Like a Girl and Age Like a Girl have helped millions of women rethink metabolic health, hormones, and aging, and she has led hundreds of thousands of people through community fasts that focus on real-world results, not quick fixes. What We Discuss: (00:00) How a Misquote Went Viral and Changed Mindy's Career (04:12) What the Internet Got Wrong About Testosterone and Fasting (11:19) The Biggest Fasting Mistakes Most People Still Make (17:05) The Six Core Types of Fasting and When to Use Each (23:28) Fasting for Gut Repair, Weight Loss, and Dopamine Reset (28:54) How Athletes and Active Women Should Adapt Their Fasts (34:04) Cycle-Based Fasting and Hormonal Timing for Women (43:00) Supplement Cycling, Autophagy, and Metabolic Flexibility (55:19) GLP-1 Drugs, Gut Health, and the Real Drivers of Hunger (59:31) The Long-Term Risks of Quick-Fix Weight Loss Trends (01:05:40) Fertility, Progesterone Needs, and Rethinking HRT (01:16:14) Menopause, Brain Rewiring, and Building Cognitive Strength (01:28:48) Peptides, ACV, and Final Insights Before Wrap-Up Thank you to our sponsors: Therasage: Head over to therasage.com and use code Be Bold for 15% off Air Doctor: Go to airdoctorpro.com and use promo code HUSTLE40 for up to $300 off and a 3-year warranty on air purifiers. Magic Mind: Head over to www.magicmind.com/jen and use code Jen at checkout. Momentous: Shop this link and use code Jen for 20% off Manna Vitality: Visit mannavitality.com and use code JENNIFER20 for 20% off your order Prolon: Get 30% off sitewide plus a $40 bonus gift when you subscribe to their 5-Day Program! Just visit https://prolonlife.com/JENNIFERCOHEN and use code JENNIFERCOHEN to claim your discount and your bonus gift. Amp fit is the perfect balance of tech and training, designed for people who do it all and still want to feel strong doing it. Check it out at joinamp.com/jen Find more from Jen:  Website: www.jennifercohen.com Instagram: @therealjencohen   Books: www.jennifercohen.com/books Speaking: www.jennifercohen.com/speaking-engagement Find more from Dr. Mindy Pelz: Website: www.drmindypelz.com Instagram: @dr.mindypelz TikTok: @drmindypelz YouTube: @drmindypelz

The Red Delta Project Podcast
Stop Giving Your Power and Freedom Away to Fitness Gurus

The Red Delta Project Podcast

Play Episode Listen Later Dec 14, 2025 64:27


If you've ever felt like you need a specific diet, program, supplement, or piece of equipment to get results, this episode is for you.In today's Red Delta Project live Q&A, I break down one of the biggest “progress traps” in fitness: dependence. The more you rely on external systems, validation, products, or ideologies, the less freedom and control you actually have… and the more likely you are to stay stuck in the fitness rat race.Then we roll straight into Q&A on elbow tendonitis from high-volume pullups, building muscle at calorie maintenance, how tempo and pauses affect hypertrophy, sissy squats, shoulder pain workarounds, autophagy hype, TRT expectations, chronic injury strategy, and more.

Intelligent Medicine
Hippocrates: All Chronic Disease Begins in the Gut, Part 1

Intelligent Medicine

Play Episode Listen Later Dec 10, 2025 29:42


Exploring the Microbiome and Longevity with Dr. Ross Pelton, Director of Science & Education for Essential Formulas Inc., which specializes in premium probiotic products. He's known as the Natural Pharmacist. He details the pivotal role of the gut in chronic disease, referencing the ancient insights of Hippocrates, and explores the concept of postbiotics. The conversation touches on the influence of gut health on various organ systems, the importance of diversity in the gut microbiome, and how lifestyle choices like diet, exercise, and sleep contribute to healthy aging. They also tackle cutting-edge topics such as the implications of GLP-1 medications, anabolic resistance, and the potential benefits of rapamycin for longevity.

How To Become A Personal Trainer
Goggins vs. Rest Days, Airplanes with Toddlers, Stomach Vacuums, Autophagy, Fasted Training, and More...

How To Become A Personal Trainer

Play Episode Listen Later Dec 9, 2025 52:56


In this episode, we discuss David Goggins vs. rest days, stomach vacuums, autophagy, fasted training, airplanes with toddlers, and more.We hope you enjoy this episode and if you'd like to join us in The Online Fitness Business Mentorship, you can grab your seat at https://www.fitnessbusinessmentorship.comThank you!-J & MWATCH this episode on YouTube: https://youtu.be/7EuldRo6eJwTIMESTAMPS:(00:00) — Intro(00:11) — Energy & fatigue levels as we age(06:00) — The strangest (& most inconvenient) way Jordan has improved his sleep...(11:36) — Experiences & advice for traveling with small children(16:27) — Dog walking etiquette & porch pirates getting what they deserve(21:31) — Online chess, Sun Tzu, & the Art of War(24:04) — The difference between a banana and a Snickers bar(24:27) — Fasted training(26:43) — Doing exercises you hate(29:59) — Weight vest recommendations(31:15) — What are the benefits of stomach vacuums?(33:08) — Age gaps & romantic relationships(34:55) — The reality of weight spikes(36:46) — Dealing with loose skin after weight loss(39:09) — Goggins vs Rest Days(43:02) — The "best" type of creatine(47:36) — Fasting & autophagy(49:24) — The truth about fitness wearables(50:20) — Things Jordan misses about Boston(52:29) — Wrap-upFollow the show on social:YouTube - https://www.youtube.com/@personaltrainerpodcastInstagram - https://www.instagram.com/personaltrainerpodcastTikTok - https://www.tiktok.com/@personaltrainerpodcastJoin our email list & get our FREE '30 Ways To Build A Successful Online Coaching Business' manual: https://bit.ly/30O2l6pCheck out our book 'Eat It!' at https://www.amazon.com/Eat-It/dp/0008543046If you have any questions you'd like to have answered on the show, shoot us an email at info@fitnessbusinessmentorship.comIf you enjoyed the episode, we would sincerely appreciate it if you left a five-star review.----Post-Production by: David Margittai | In Post MediaWebsite: https://www.inpostmedia.comEmail: david@inpostmedia.com© 2025 Michael Vacanti & Jordan Syatt

Jaxon Talks Everybody
#436 - Ashley Bizzell - Fasting and Metabolic Health: A New Perspective

Jaxon Talks Everybody

Play Episode Listen Later Dec 9, 2025 56:06


Ashley Bizzell joins Something For Everybody this week. Ashley is a registered dietitian and certified diabetes care and education specialist with over fifteen years of experience. In this conversation, Ashley and I discuss various aspects of health and nutrition, focusing on the importance of what we stop eating, the role of metabolic health, and the significance of habit formation. We explore the fasting mimicking diet, its benefits, and how it can help improve overall health.  - See discounts for all the products I use and recommend: https://everybodyspod.com/deals/ - Shop For Everybody  Use code SFE10 for 10% OFF

Age Well with Dr Sophie Shotter
Why spermidine is the longevity supplement going mainstream in 2026 - with Primeadine's Leslie Kenny

Age Well with Dr Sophie Shotter

Play Episode Listen Later Dec 9, 2025 41:04


Leslie's story | the birth of Oxford Healthspan | spermidine and the immune system | the latest data on spermidine and cancer | spermidine and fertility | Primeadine's USP | Leslie's recovery and her approach to good health

Tater Talks: Two Bitches Talk Fitness
Fasting, Autophagy, and Inflammation: What Women Really Need to Know

Tater Talks: Two Bitches Talk Fitness

Play Episode Listen Later Dec 8, 2025 54:46


In today's episode, I'm literally on the walking pad with a baby in the wrap while Amy's in her office and surprise guest Beth is joining us from the car - because this is real life and we always make it work. We dove into a topic that's been popping up nonstop in our communities lately: intermittent fasting, autophagy, inflammation, and all the fear-based protocols targeting women, especially menopausal and perimenopausal women. This conversation is part science, part mindset, and part “please stop overcomplicating your life.”We break down what autophagy actually is, and answer the question: is fasting the magical lever people are pulling it off as? We chat about how chronic inflammation gets twisted into a marketing scheme instead of something you can support with simple, foundational habits. Most importantly, we talk about the psychological fallout… how these rigid protocols disconnect you from your hunger cues, fuel all-or-nothing thinking, and keep you believing you're fragile, broken, or in need of secrets. Spoiler: you're not.“We are not fragile. We are not broken. We are not delicate - and you don't need a protocol to fix what was never damaged.”- Amy Rudolph“You cannot read the label when you're inside the jar - and so many women don't realize how good they could feel until they stop following rules that were never meant for them.”- Iris DeadliftsThis week on Here's the Deal: Fitness, Nutrition and Mindset for People Who Don't Want Life to Suck:What is autophagy and what does it do? How do we get it?The truth about inflammation: the difference between chronic vs. acute, and why skipping meals doesn't “heal” anythingHow fasting rules disconnect women from hunger cues and mimic disordered eating patternsWhy most clients who attempt intermittent fasting end up overeating at night and struggling with protein intakeHow “fear-based protocols” target menopausal women with misinformation, secrecy, and false authorityThe psychological toll of chasing hacks, cycle-syncing rules, and hormone micromanagementReal-life performance wins from fueling before workouts instead of training fastedThe only things that consistently support health and longevity: sleep, strength training, protein, fiber, movement, stress management—the “boring basics”Connect with Us:Iris Deadlifts on InstagramAmy Rudolph on InstagramWork with us at Beth Feraco FitnessThanks for tuning in to this week's episode of Here's the Deal: Fitness, Nutrition, and Mindset for People Who Don't Want Life to Suck, where we challenge the common understanding of what it means and what it takes to be fit and healthy! If you enjoyed this episode, don't forget to subscribe and leave a review wherever you listen to your favorite podcasts.Apple Podcasts | SpotifyBe sure to share your favorite episodes on social media and tag us!Join Iris Deadlifts on Instagram, Meri on Instagram, and Amy Rudolph on Instagram.

Dr. Jockers Functional Nutrition
The Science of Protein Cycling, Autophagy and Fat Loss with Vanessa Spina

Dr. Jockers Functional Nutrition

Play Episode Listen Later Dec 2, 2025 63:01


In this episode, Dr. Jockers and Vanessa Spina break down new human research showing why high protein doesn't block autophagy when calories are low. You'll learn how this changes everything we've believed about protein timing, fasting, and cellular repair. The conversation also reveals why prioritizing protein can accelerate fat loss without sacrificing muscle.   You'll hear how protein impacts appetite, hormones, and metabolic flexibility—and why many people overeat simply because they're under-consuming essential amino acids. Vanessa explains the protein leverage effect and how it naturally reduces cravings, stabilizes blood sugar, and makes eating "effortlessly" satisfying. These insights can help you rethink how you build your daily meals.   You'll discover why certain fasting styles can increase visceral fat loss, support hormonal balance, and boost performance. Expect a mix of science, real-world application, and surprising findings you may not have heard before.     In This Episode:  00:00 Introduction and Exciting New Study 00:21 Welcome and Guest Introduction 00:30 Deep Dive into the New Study 01:52 Vanessa Spina's Expertise and Background 05:47 Interview with Vanessa Spina Begins 06:15 Discussion on Protein Absorption Study 14:04 Personal Experiences with Protein and Fasting 16:55 Debunking Protein Myths 18:10 Nutrition Principles and Protein Prioritization 22:23 Ketones, Satiety, and Inflammation 27:07 Balancing Hormones and Stress 31:17 Understanding Autophagy and Protein Intake 32:35 The Importance of Human Trials in Research 35:11 Study on High Protein Fasting Mimicking Diet 38:38 Results and Implications of the Study 42:18 Personal Experiences with Protein-Sparing Modified Fasting 45:32 Practical Tips for Implementing Protein-Sparing Modified Fasting 57:54 Comparing Different Fasting Approaches 01:01:13 Conclusion and Final Thoughts   Hydration is one of the fastest ways to boost your energy, sharpen your focus, curb cravings, and even improve the look and feel of your skin — but water alone isn't enough. Your cells need electrolytes to actually absorb and use that hydration. Paleovalley Essential Electrolytes delivers premium, full-spectrum minerals with zero sugar, no artificial ingredients, and unprocessed sea salt, helping you feel more energized, clear-headed, and vibrant — and look more radiant from the inside out. Just one scoop a day can make a noticeable difference. Try Paleovalley Essential Electrolytes and save 15% by visiting Paleovalley.com/jockers and using code JOCKERS at checkout.   I just wanna take a moment to interrupt this podcast to tell you about one of my favorite podcasts I listen to. It's called The Dr. Josh Axe Show, hosted by my good friend Dr. Josh Axe. Every week he shares how to balance your hormones, restore your gut, boost your energy, and slow aging without relying on harsh medications or quick fixes. He shares both ancient biblical practices and the latest breakthroughs in nutrition, herbal remedies, and lifestyle medicine. If you're ready to take control of your health, renew your energy, and transform your mind, body, and spirit, tune into The Dr. Josh Axe Show every Monday and Thursday wherever you get your podcasts.     "Most people don't overeat because they lack willpower — they lack protein."      Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean TuneIn Radio     Resources: Study Referenced: https://www.researchgate.net/publication/394359134_Effects_of_fasting-mimicking_diets_with_low_and_high_protein_content_on_cardiometabolic_health_and_autophagy_A_randomized_parallel_group_study Get 15% off Paleovalley Electrolites: paleovalley.com/jockers – Use code JOCKERS     Connect with Vanessa Spina: Website: ketogenicgirl.com   Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https://www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/ If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/ 

The Keto Kamp Podcast With Ben Azadi
#1167 The 36-Hour Fast That Reboots Your Metabolism: How Autophagy, Ketones, and HGH Transform Your Body From the Inside Out With Ben Azadi

The Keto Kamp Podcast With Ben Azadi

Play Episode Listen Later Nov 26, 2025 21:59


In this episode, Ben Azadi breaks down the science and real-life experience behind a 36-hour fast, explaining why this specific fasting window creates a powerful metabolic, hormonal, and cellular reset. Ben walks listeners through the hour-by-hour stages of the fast — from digestion, to fat burning, to deep autophagy — and explains how fasting transforms the body at every level. He covers increases in human growth hormone, gut repair, ketone production, mitochondrial upgrades, and the mental clarity that comes from elevated BDNF. He also answers the most common questions about long fasts:• What drinks or supplements break a fast• Whether women should modify fasting based on their cycle• How often to repeat a 36-hour fast• What symptoms are normal vs. concerning• Whether fasting impacts muscle• How to eat before and after a long fast for best results Ben also explains who should not attempt a 36-hour fast and how to break the fast without losing the benefits. He emphasizes that fasting is not starvation — it's a biological event designed for healing, fat loss, and metabolic restoration. FREE GUIDE: The World's Easiest Breakfast Diet - https://bit.ly/4puckHV 

Intelligent Medicine
Intelligent Medicine Radio for November 22, Part 1: Can surgical anesthesia accelerate memory loss?

Intelligent Medicine

Play Episode Listen Later Nov 24, 2025 44:05


The School of Doza Podcast
RERELEASE: Unlocking the Power of NAD

The School of Doza Podcast

Play Episode Listen Later Nov 24, 2025 67:19


Energize your life and rejuvenate at the cellular level with Mitochondriac, the ultimate mitochondrial rejuvenation supplement. Packed with powerhouse ingredients for optimal health, it's like getting the benefits of NAD in a convenient, family-friendly pill form. Dive in and transform your health journey today: https://www.mswnutrition.com/products/mitochondriac   Time Stamps: 00:00 START 02:29 Mitochondrial Power 04:54 Combatting Aging 09:39 Nourishing Cells 11:34 Brain Boost 13:53 Nutritional Sources 16:12 The NAD Experience 18:35 Key to Production 21:01 Repair and Rejuvenation 23:24 The Autophagy Effect 25:49 Insulin's Role 27:51 Biogenesis Breakthrough 30:15 Resveratrol: A Synergistic Ally 32:25 Final Insights Show Notes: Nurse Doza takes listeners on an informative journey through the vital role of NAD in maintaining energy, supporting brain function, and ensuring cellular health. He emphasizes how aging leads to a natural decline in NAD levels, affecting our overall wellness. Through an exploration of how Mitochondriac can serve as an oral alternative to NAD supplementation, Doza offers actionable insights for anyone looking to enhance their health span and live a more vibrant life. He discusses Mitochondriac's role in supporting mitochondrial function, thereby promoting longevity and vitality.   URLs for References: School of Doza Sign-up: https://schoolofdoza.com/sign-up Importance of NAD: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7442590/ Supporting Brain Health: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787556/ Cellular Repair and Autophagy: https://www.cell.com/developmental-cell/fulltext/S1534-5807(22)00760-2The Power of Resveratrol: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342515/ Discover the secret to youthful energy and cellular health with Mitochondriac, your daily dose of mitochondrial rejuvenation. This powerhouse supplement is designed to replicate the effects of NAD supplementation, supporting your health from the cellular level up. Begin your journey towards a more energetic, vibrant life now:https://www.mswnutrition.com/products/mitochondriac  

Intelligent Medicine
Leyla Weighs In: Rethinking Alzheimer's

Intelligent Medicine

Play Episode Listen Later Nov 21, 2025 25:15


Nutritionist Leyla Muedin focuses on a new perspective in Alzheimer's research, particularly the role of microglial cells. She reveals insights from integrative neurologist Dr. David Perlmutter's presentation at the Integrative Healthcare Symposium, emphasizing the significance of microglial cells in Alzheimer's disease. The discussion highlights the traditional focus on beta amyloid plaques and introduces the importance of shifting from the M1 pro-inflammatory phenotype to the M2 anti-inflammatory phenotype of microglial cells. Dr. Perlmutter advocates for addressing systemic metabolic and inflammatory issues, pointing out factors like poor diet, lack of sleep, and high blood sugar, which are crucial in preventing Alzheimer's. The episode delves into lifestyle interventions such as ketogenic diets, fasting, and nutritional impacts to manage and potentially reverse the detrimental shift in microglial behavior.

Dr. Jockers Functional Nutrition
The Shocking Benefits of Eating No Food for 72 Hours with Ben Azadi

Dr. Jockers Functional Nutrition

Play Episode Listen Later Nov 11, 2025 60:27


In this episode, Dr. David Jockers joins Ben Azadi to break down what really happens inside your body during a 72-hour fast — from burning stored fat to reducing inflammation in the brain. Together, they explore how fasting resets dopamine, boosts mental clarity, and strengthens emotional resilience while tapping into your body's innate healing power.   You'll hear Dr. Jockers and Ben discuss how autophagy clears out old, damaged cells and replaces them with stronger, more stress-resilient ones. They also dive into how fasting triggers the creation of new mitochondria — your body's energy factories — helping you burn fat more efficiently and age more gracefully.   Finally, discover how fasting boosts growth hormone and resets your immune system, leading to greater energy, sharper focus, and improved longevity. Whether you're new to fasting or ready to take it to the next level, this episode reveals the science and strategy behind one of nature's most powerful healing tools.   In This Episode:  00:00 Introduction to Sacrifice and Dopamine 04:45 The Science of Fasting: 12 to 24 Hours 14:27 Autophagy and Metabolic Health 16:41 Air Quality and Autophagy Explained 28:29 Preparing for a Successful Fast 34:19 Understanding Cravings During Fasting 34:30 Timing Fasting with Menstrual Cycles 34:53 Managing Hunger and Ghrelin 36:03 Benefits of Extended Fasting 36:37 Fat Burning and Liver Health 38:41 Fasting and Intestinal Health 42:00 Dopamine Reset and Fasting 48:15 Supplements and Liquids During Fasting 54:59 Breaking the Fast and Refeeding 58:03 Gratitude and Final Thoughts   Hydration is one of the fastest ways to boost your energy, sharpen your focus, curb cravings, and even improve the look and feel of your skin — but water alone isn't enough. Your cells need electrolytes to actually absorb and use that hydration. Paleovalley Essential Electrolytes delivers premium, full-spectrum minerals with zero sugar, no artificial ingredients, and unprocessed sea salt, helping you feel more energized, clear-headed, and vibrant — and look more radiant from the inside out. Just one scoop a day can make a noticeable difference. Try Paleovalley Essential Electrolytes and save 15% by visiting Paleovalley.com/jockers and using code JOCKERS at checkout.   Breathe cleaner, healthier air at home with AirDoctor, the award-winning air purifier that eliminates up to 99.99% of airborne contaminants — including allergens, mold spores, and viruses. It's the same purifier trusted by top wellness experts for a reason. Visit AirDoctorPro.com and use promo code NUTRITION to get up to $300 off plus a free 3-year warranty. Breathe easier and protect what matters most.     "By tapping into body fat and producing ketones, your brain can function more clearly and reduce inflammation."        Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean TuneIn Radio     Resources: Get 15% off Paleovalley Electrolites: paleovalley.com/jockers – Use code JOCKERS Visit AirDoctorPro.com and use code NUTRITION for up to $300 off plus a free 3-year warranty.   Connect with Ben Azadi: Website:  https://www.benazadi.com/ Book:  https://amzn.to/41O02jk Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https://www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/ If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/ 

Aging Well Podcast
Autophagy, Mitochondrial Health, & Lifespan Optimization | Leslie Kenny | Ep. 318

Aging Well Podcast

Play Episode Listen Later Nov 9, 2025 74:24


In this episode of ‘The Aging Well Podcast', Dr. Jeff Armstrong is joined by Leslie Kenny—Harvard graduate, Oxford Longevity Project founder, and self-described “age rebel.” At 60 years old, Leslie has achieved a biological age of 21—and she's on a mission to help others do the same.From reversing autoimmune disease to mastering mitochondrial health, Leslie breaks down the science of aging in a way that's both inspiring and deeply practical. Learn how shifts in immunity, cellular cleanup (autophagy), and lifestyle decisions can help you stay sharp, energized, and resilient—especially after 40.If you're ready to take control of how you age, this episode offers the tools, science, and encouragement to help you live better, longer.Learn more about Leslie Kenny and the Oxford Longevity Project at: https://oxfordlongevityproject.org/Please, support The Aging Well Podcast by hitting the ‘like' button, subscribing/following the podcast, sharing with a friend, and….BUY the products you need to… age well from our trusted affiliates and support the mission of The Aging Well Podcast*.Oxford Healthspan | Primeadine®, a plant-derived spermidine supplement | 10% off code: AGINGWELL | https://oxford-healthspan.myshopify.com/AgingWellThe Aging Well Podcast merchandise | Show how you are aging well | Use the promo code AGING WELL for free shipping on orders over $75 | https://theagingwellpodcast-shop.fourthwall.com/promo/AGINGWELLAuro Wellness | Glutaryl—Antioxidant spray that delivers high doses of glutathione (“Master Antioxidant”) | 10% off Code: AGINGWELL at https://aurowellness.com/agingwellpodcastRebalance Health | products created by hormone health experts to lower cortisol, improve sleep, and minimize the impact of stress on the body and mind | https://rebalancehealth.com with the promo code: AGING WELLJigsaw Health | Trusted supplements. “It's fun to feel good.” | Click the following link for 10% off: https://www.jigsawhealth.com/?rfsn=8710089.1dddcf3&utm_source=refersion&utm_medium=affiliate&utm_campaign=8710089.1dddcf3Prolon | The Fasting Mimicking Diet (FMD) is a revolutionary five-day nutrition program scientifically formulated to mimic the effects of a prolonged water fast while still allowing nourishment - supporting the benefits of fasting without the challenges and risks that come from water-only fasts. | For the best available discount always use this link: https://prolonlife.com/theagingwellpodcastL-Nutra Health | The medical division of L-Nutra, focused on helping people manage and potentially reverse chronic health conditions, like type 2 diabetes, prediabetes, insulin resistance, and obesity, using personalized, lifestyle-based programs grounded in evidence, not prescriptions. | Use this link: https://l-nutrahealth.com/theagingwellpodcastFusionary Formulas | Combining Ayurvedic wisdom with Western science for optimal health support. | 15% off Code: AGINGWELL | https://fusionaryformulas.com/Dr Lewis Nutrition | Fight neurodegeneration and cognitive decline with Daily Brain Care by Dr Lewis Nutrition—a proven daily formula designed to protect and restore brain function. | 10% off code: AGINGWELL or use the link: https://drlewisnutrition.com/AGINGWELLThrive25—Your personal longevity advisor | https://www.thrive25.com/early-access?via=william-jeffreyTruDiagnostic—Your source for epigenetic testing | 12% off Code: AGEWELL or use the link: https://shop.trudiagnostic.com/discount/AGEWELL*We receive commission on these purchases. Thank you.4

The Keto Kamp Podcast With Ben Azadi
#1151 What Happens to Your Body When You Only Drink Water for 24 Hours: The Truth About Fatty Liver, Autophagy, and Metabolic Healing With Ben Azadi

The Keto Kamp Podcast With Ben Azadi

Play Episode Listen Later Nov 8, 2025 19:06


What really happens when you drink only water for 24 hours? In this episode, Ben Azadi breaks down the powerful science behind fasting and how it can help heal a fatty liver, reduce inflammation, and reignite your body's natural fat-burning ability. You'll learn: Why constant snacking keeps your liver in “storage mode” The hour-by-hour breakdown of a 24-hour water fast How fasting triggers autophagy, your body's internal cleanup system The natural surge in human growth hormone that supports fat loss and longevity Exactly how to prepare for, complete, and break your fast safely Plus, Ben shares a free 7-day fat loss protocol to help you reset your metabolism and burn one pound of fat per day — without counting calories or overtraining.

The Homeschool How To
#145: Functional Medicine Doesn't Have to Be Confusing—Here's What It Really Means | Dr. Dusty Hess

The Homeschool How To

Play Episode Listen Later Nov 8, 2025 62:38 Transcription Available


Is your child struggling with ADHD, allergies, or chronic illness? Wondering why childhood health is declining despite modern medicine?In this episode, functional medicine doctor Dr. Dusty Hess explains the root causes behind rising rates of ADHD, autism, and infertility—and shares practical solutions every family can implement today.What You'll Learn: ✅ Functional medicine vs. conventional healthcare (firefighters vs. builders) ✅ How plastics, seed oils, and processed foods disrupt hormones ✅ The truth about vaccines and personalized health approaches ✅ Why inflammation is both friend and foe ✅ The shocking infertility crisis: sperm counts down 50% in 50 years ✅ Autophagy and intermittent fasting made simple ✅ Practical swaps for your kitchen, home, and daily routine ✅ Why homeschool families are uniquely positioned for better healthAbout Dr. Dusty Hess: Dr. Dusty is a functional medicine doctor, founder of Upstream Health, and creator of Upstream Magazine—a monthly publication helping Christian families get healthy from the inside out.Resources: Explore everything Upstream Health has to offer at www.upstreamhealth.comOur free ADHD webinar shares guidance, tools, and encouragement from our care team to support you or someone you love navigating ADHD. https://upstreamhealth.com/webinar-landing/Upstream Health link-tree: https://upstreamhealth.com/link-tree/ Perfect for: Homeschool parents, Christian families, moms seeking natural health solutions, anyone dealing with chronic childhood illness, ADHD, autism, or fertility challenges.

Fast Keto with Ketogenic Girl
Burn Fat, Keep Muscle: Inside the Science of the Protein-Sparing Modified Fast

Fast Keto with Ketogenic Girl

Play Episode Listen Later Nov 7, 2025 44:44


Beat BLOAT & unlock better protein absorption and digestion with MassZymes by BiOptimizers. NOW GET 15% off your order with the code VANESSA at bioptimizers.com/vanessa In this solo episode, Vanessa Spina breaks down the science and strategy behind one of the most effective tools for rapid fat loss and muscle preservation — the Protein-Sparing Modified Fast (PSMF). Following her in-depth interview with Dr. David Jockers, Vanessa explains exactly how this approach works, why it's so powerful for resetting metabolism, and how to implement it safely for optimal results. If you've ever wondered how to burn fat quickly without losing muscle, how to overcome plateaus, or how to use short, strategic fasting phases for body recomposition, this episode is your ultimate guide. Timeline Mitopure Gummies — The #1 Urolithin A supplement for energy and healthy aging, now in delicious strawberry gummies. Get 20% off at timeline.com/vanessa

Women's Power to Heal Mother Earth!
Episode 180 - The Power of a Cell

Women's Power to Heal Mother Earth!

Play Episode Listen Later Nov 5, 2025 9:44


Send us a textThousands of years before modern science emerged, the ancient science of Ayurveda propagated this prescient knowledge of the body's cellular anatomy, its recalibration and maintenance as the imperative to maintaining excellent health. In Ayurveda, the principle of autophagy is only one core part of a greater plethora of cellular function of the cellular anatomy, which in Sanskrit is referred to Śarīra Paramānus/Anu Srotāmsi, a vast invisible network of living units of the body analogous to modern cells. Today, science is progressively proving what the ancient rishis knew. Thanks to Yoshinori Oshumi cellular recycling now has a modern scientific name. Ohsumi, a brilliant biologist in Tokyo won the Nobel Prize in 2016 for “discovering” autophagy” the process where cells break down and recycle their own damaged components to survive and stay healthy. Ohsumi's work and findings are outstanding, and open the door to greater scientific knowledge of the cellular anatomy. Autophagy is a natural function of cell recycling, the process in which cells degrade and  recycle cellular components by breaking down and reusing damaged or unnecessary components within a cell. Autophagy is essential for a cell to function and to manifest the energy that it needs. Fully functional cells help us survive during periods of physical, emotional and spiritual stress. It can destroy pathogens like viruses and bacteria that have entered a cell. Cells are the basic building blocks of every tissue and organ in your body. Each cell contains multiple parts that keep it functioning. Over time, these parts can become defective or stop working. By deconstructing old parts of their cells they don't need, cells can recreate these junky bits into functioning cells they need to survive. Support the showMay Peace Be Your Journey~www.mayatiwari.comwww.facebook.com/mayatiwariahimsa.Buzzsprout.com Get Maya's New Book: I Am Shakti: https://www.collectiveinkbooks.com/o-books/our-books/I-am-shakti Amazon.com Bookshop.org

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

Huberman Lab

Play Episode Listen Later Oct 30, 2025 39:07


In this Huberman Lab Essentials episode, my guest is Dr. David Sinclair, PhD, a professor of genetics at Harvard Medical School and a leading expert on the biology of aging. We discuss the cellular and molecular mechanisms of aging—and how specific behaviors, such as fasting, regular exercise and NAD⁺-boosting compounds like NMN, can activate the body's natural longevity pathways. This discussion highlights how lifestyle choices profoundly influence the aging process and may even slow or reverse key aspects of biological aging. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AGZ by AG1: https://drinkagz.com/huberman David: https://davidprotein.com/huberman Eight Sleep: https://eightsleep.com/huberman Timestamps (0:00) David Sinclair (0:20) Longevity, Anti-Aging, Aging as a Disease (2:27) Causes of Aging; Epigenome & Genes (4:53) CD & Scratches Analogy, DNA, Silencing & Expressing Genes (6:44) Physical Appearance & Aging (7:36) Sponsor: David (8:54) Childhood Development & Aging, Horvath Clock, Accelerate Aging (11:30) Rates of Puberty & Aging, Growth Hormone (12:37) Body Size & Longevity; Epigenetics (13:07) Fasting, Calorie Restriction & Longevity, Sirtuins, Insulin & Glucose (16:31) Tool: Skip a Meal (17:07) Longer Fasts & Autophagy, “Deep Cleanse” (18:07) Sponsor: AGZ by AG1 (19:36) Fasting, Fluids, Electrolytes (20:16) Sirtuins, Glucose, mTOR & Fasting; Leucine, Tool: Pulsing Behaviors (24:24) Breaking a Fast, Tools: Do Your Best; Transitions (27:00) Sirtuins, NAD, NMN Supplementation (29:04) Sponsor: Eight Sleep (31:10) Iron & Senescent Cells; Personalize Medicine (32:40) Tool: Blood Markers, CRP (34:50) Tool: Aerobic & Resistance Exercise (35:55) Estrogen, Fasting & Fertility; Aging & Rejuvenation (38:20) Acknowledgements Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

The Red Light Report
The New Era of BioBlue: Inside the Upgraded Mitochondrial Formula

The Red Light Report

Play Episode Listen Later Oct 30, 2025 64:21


In this solosode of The Energy Code, Dr. Mike unveils the most comprehensive update yet to BioLight's flagship supplement — BioBlue — and takes listeners deep inside the quantum bioenergetic thinking that shaped its redesign. What began as a methylene-blue-based mitochondrial catalyst has evolved into a next-generation longevity systemintegrating deuterium-depleted water, elevated NMN, taurine, and trace gold-silver resonance compounds.   Dr. Mike breaks down the science and reasoning behind each refinement: why Litewater's 10 ppm deuterium-depleted water now forms the clean matrix for all BioBlue liquids, how NMN has been increased ten-fold (10 mg → 100 mg) to meaningfully expand NAD⁺ pools and drive biogenesis, and how taurine stabilizes mitochondrial membranes and calcium signaling for endurance and resilience. He explains the subtle yet powerful tweaks — like a 50 % increase in colloidal gold and silver and a 40 % reduction in fulvic acid — that sharpen redox coherence and enhance longevity signaling.   Dr. Mike dives into: Overview of how BioBlue progressed from a simple methylene-blue solution to a full mitochondrial optimization system. Why all BioBlue liquids now utilizes Litewater for cleaner proton flow and improved ATP efficiency. Why NMN increased from 10 mg → 100 mg per dose to meaningfully raise NAD⁺ levels, drive biogenesis, and enhance DNA repair. Why the addition of Taurine – 100 mg per serving for membrane stability, calcium regulation, and long-term mitochondrial resilience. Enhanced Trace Elements – 50 % more colloidal gold & silver plus refined fulvic acid for smoother redox flow and higher photodynamic efficiency.   This episode isn't just about formulation — it's about why every molecule matters in the pursuit of mitochondrial efficiency, redox stability, and long-term cellular youthfulness. Mike also previews BioLight's upcoming new website, pre-Black-Friday event, and a soon-to-launch BioBlue Lite product line for those seeking simplicity without compromise.   Key Topics Covered Evolution of BioBlue — from the original methylene blue + NMN formula to a comprehensive mitochondrial optimization system. Integration of Deuterium-Depleted Water (Litewater, 10 ppm) — explanation of how lowering deuterium enhances ATP production, redox efficiency, and longevity potential. NMN Upgrade (10× Increase) — new 100 mg per serving dosage for boosting NAD⁺ levels, mitochondrial biogenesis, DNA repair, and energy metabolism. Addition of Taurine (100 mg per serving) — supports membrane integrity, calcium balance, ROS buffering, and cellular longevity signaling. Enhanced Colloidal Gold & Silver (50 % Increase) — improved redox stability, electron flow, and photodynamic synergy with methylene blue and red light. Refined Wu Jin Sun Fulvic Acid (−40 %) — optimizes redox balance and mineral transport while improving synergy between all active compounds. Comprehensive Mitochondrial Benefits — improved ATP efficiency, autophagy, and mitochondrial biogenesis for cleaner, more resilient energy production. New Product Lineup — introduction of BioBlue Lite and BioBlue Leuco Lite (simplified methylene blue + water versions) for accessible mitochondrial support. Key Quotes from Dr. Mike   “Deuterium-depleted water doesn't just make the mitochondria go faster—it helps them run truer, cleaner, and more efficiently.”   “We've moved BioBlue from a trace metabolic nudge to a real mitochondrial optimization protocol that supports redox cycling, biogenesis, and longevity pathways in a quantifiable way.”   “Taurine turns BioBlue from a fast-acting energy compound into a cellular longevity stack—supporting repair, recycling, and resilience.”   “By increasing colloidal gold and silver within their optimal bio-signal zones, BioBlue transforms from a chemical redox supplement into a biophysical energy transducer.”   “Each change — from Litewater to taurine — was made to help your mitochondria run longer, cleaner, and more accurately. This is longevity through bioenergetics.” Episode Timeline 00:00 – Announcements: Pre-Black Friday + new website 04:00 – The origin of BioBlue and its evolution 10:00 – Introducing the upgraded BioBlue formula 11:00 – Why BioLight partnered with Light Water 12:00 – How deuterium slows mitochondrial ATP production 17:00 – Functional benefits of deuterium-depleted water 19:00 – 10x increase in NMN for energy and repair 27:00 – Synergy between NMN and methylene blue 30:00 – Adding taurine for stability and longevity 39:00 – Increasing colloidal gold for photonic synergy 46:00 – Boosting colloidal silver for redox protection 52:00 – Why lowering fulvic acid improves coherence 56:00 – What's next: BioBlue Light + legacy pricing offer 01:02:00 – Dr. Mike's closing thoughts on mitochondrial optimization Resources & References Deuterium Depletion and Mitochondrial Efficiency Boros, L. G. Deuterium Depletion and Cellular Bioenergetics. Frontiers in Oncology (2020). Sagalevsky, V. — Light Water: The Science of Deuterium-Depleted Hydration (interview referenced in episode).   Nicotinamide Mononucleotide (NMN) & NAD⁺ Metabolism Mills, K. F. et al. Long-term administration of NMN mitigates age-associated physiological decline in mice. Cell Metabolism (2016). Yoshino, J. et al. NAD⁺ intermediates: The biology and therapeutic potential of NMN and NR. Cell Metabolism (2018).   Taurine and Longevity Pathways Wang, W. et al. Taurine deficiency as a driver of aging. Science (2023). Schaffer, S. W. et al. Physiological roles of taurine in the heart and mitochondria. Journal of Biomedical Science (2010).   Colloidal Gold & Silver in Cellular Redox Systems Li, Y. et al. Gold nanoclusters enhance mitochondrial cytochrome c oxidase activity. ACS Nano (2019). Kim, Y. S. et al. Silver nanoparticles exhibit SOD- and catalase-like activity for redox modulation. Nano Research (2020).   Fulvic & Humic Acids as Bioactive Redox Modulators   Senesi, N. Nature of humic substances and their interactions with trace metals and organics in the environment. Soil Science (1992). Wu Jin San extract — traditional Chinese “gold medicine” formulation known for enhanced mineral transport and detoxification support.     Additional Mentions PGC-1α, SIRT1/SIRT3, and Autophagy pathways in mitochondrial biogenesis and longevity. Quantum redox coupling and plasmonic resonance as mechanisms for light-driven bioenergetic optimization.  

Healthy Lifestyle Made Simple​ With Rimon N. Lumen
#1 Absolute EASIEST Way to Activate Autophagy (JustTwice a Month!)

Healthy Lifestyle Made Simple​ With Rimon N. Lumen

Play Episode Listen Later Oct 25, 2025 11:07


In this NEW video I explain the specifics of my routine.Download Rimon's PDF exercise list and support his work at: https://Rimon.Vip

The Human Upgrade with Dave Asprey
These Plants Turn On 1,100 Healing Genes In 24 Hours (Ancient Biohacks) : 1346

The Human Upgrade with Dave Asprey

Play Episode Listen Later Oct 16, 2025 56:52


Most people try to “heal” their brain with supplements, mindset, or meditation—but this episode reveals the deeper protocol to actually grow a new brain, reverse stress damage, activate 1,100 healing genes, and unlock higher human performance at any age. You'll learn how neuroplasticity, mitochondria repair, plant-based NRF2 activators, and energetic practices work together to rebuild the brain and extend longevity. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Alberto Villoldo, Ph.D.—medical anthropologist, neuroscientist, energy medicine pioneer, and founder of The Four Winds Society, the gold-standard school for modern shamans. He has spent 25+ years studying Amazonian and Andean healing traditions, led the Biological Self-Regulation Lab at San Francisco State University to explore psychosomatic medicine, and authored more than 25 bestselling books on neuroscience, functional medicine, and energy healing. Few people on earth bridge ancient biohacking and modern brain science at this level. He also reveals the forms of nicotine that are safest (spoiler: it's not vapes or cigarettes), how nicotine works at the receptor level, and what the science says about long-term health effects. This episode blends functional medicine, brain optimization, and biohacking into one powerful, myth-busting breakdown. You'll learn: • How to grow a new brain every 22 days using neuroplasticity and mitochondria support • Why plant medicines and NRF2 activators can turn on 1,100 healing genes in 24 hours • The surprising link between nootropics, psychedelics, serotonin, and endogenous DMT • How mindset, belief systems, and placebo/nocebo shape immune function and metabolism • Why RFK's chronic disease warning connects to viral evolution and immune collapse • The real reason carnivore diets work—and when they fail without gut repair • Peptides, GLP-1 agonists, and the future of functional medicine hacking • Why most people sabotage themselves and how to stop fighting your own biology This is essential listening for anyone serious about biohacking, human performance, and longevity, and for those who want to understand how functional biology and mitochondrial science are redefining recovery, energy, and aging. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: NRF2 activation, Neurogenesis and hippocampus repair, Plant-based epigenetic triggers, Psychosomatic health, Serotonin to DMT conversion, Pineal gland methylation, Parasites and brain inflammation, Viral-driven evolution, GLP-1 agonists and longevity, Psilocybin lifespan extension, Autophagy and brain cleanup, Energetic medicine training, Functional peptides, BPC-157, Breathwork and CO2 tolerance, mTOR cycling, Cold exposure and dopamine, Mindset-driven immune function Thank you to our sponsors! • EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off. • Essentia | Go to https://myessentia.com/dave and use code DAVE for $100 off The Dave Asprey Upgrade. • Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. • fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. Resources: • Learn more from Alberto at: www.thefourwinds.com and www.albertovilloldo.net • Buy the book ‘Grow A New Brain': https://a.co/d/5lVhrVy • Business of Biohacking | Register to attend October 20-23 in Austin, TX https://businessofbiohacking.com/ • Danger Coffee: https://dangercoffee.com/discount/dave15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Trailer 1:25 — Introduction & Ayahuasca Story 3:15 — Shamanism Beyond Plant Medicine 6:53 — Losing Your Mind to Evolve 10:45 — The 22-Day New Brain Cycle 12:53 — Plant Communication & Direct Knowing 15:35 — Parasites, Liver Failure & Brain Damage 20:25 — Remote Healing & CIA Research 22:40 — Tryptophan, Turkey Farmers & Brain Chemistry 25:19 — Viruses as Evolutionary Drivers 30:30 — Psilocybin & Life Extension 35:25 — Healing with Mindset + Biology 38:52 — Spirit, Purpose & Growing Gods 43:49 — Plants, Protein & mTOR 49:07 — Training the Four Brains 51:16 — Cold Exposure: Pain vs Suffering 54:40 — Who Am I? Living the Question 55:25 — Closing See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Project Weight Loss
The Autophagy Maester - Yoshinori Ohsumi: The Science of Self-Renewal

Project Weight Loss

Play Episode Listen Later Oct 16, 2025 20:21


Send us a textHave you ever wondered what happens inside your body when you don't eat for a while — when you give yourself space between meals? In this week's episode of Project Weight Loss, we explore that quiet magic with the story of Nobel Laureate Maester Yoshinori Ohsumi, whose discovery of autophagy — the body's natural process of self-cleaning and renewal — changed how we understand health, vitality, and longevity. From his humble lab in Japan to the moment he glimpsed a new world under the microscope, Ohsumi's curiosity reveals how our bodies are wired to restore themselves, especially in moments of pause.We'll talk about how autophagy connects to fasting, weight management, brain health, and aging — and why giving your body a little space to “dine in” can make such a difference. You'll hear about Ohsumi's groundbreaking experiments, his partnership with his wife and collaborator Mariko Ohsumi, and how their discoveries invite us to see self-renewal as a natural rhythm of life. I'll also link this episode to my earlier one on the Blue Zones — where long-living communities show us what it means to live in harmony with our biology. Listen in, reflect, and maybe even give your body that gentle reset it's been asking for.Quote of the Week:“We are wired for feast and famine, not feast, feast, feast.” — Dr. Jason FungListen to my related episode: The Blue Zones: The Secrets to Living Citations1.    Ohsumi, Y. (2014). Historical landmarks of autophagy research. Cell Research, 24(1), 9–23. https://doi.org/10.1038/cr.2013.1692.    Mizushima, N., & Ohsumi, Y. (2002). Autophagy: Molecular machinery for self-eating. Cell, 120(4), 639–652.3.    Kaushik, S., & Cuervo, A. M. (2018). The coming of age of chaperone-mediated autophagy. Nature Reviews Molecular Cell Biology, 19(6), 365–381.4.    Madeo, F., Zimmermann, A., Maiuri, M. C., & Kroemer, G. (2015). Essential role for autophagy in life span extension. Journal of Clinical Investigation, 125(1), 85–93.5.    Longo, V. D., & Panda, S. (2016). Fasting, circadian rhythms, and time-restricted feeding in healthy lifespan.Cell Metabolism, 23(6), 1048–1059.6.    Fung, J. (2016). The Obesity Code: Unlocking the Secrets of Weight Loss. Greystone Books.Let's go, let's get it done. Get more information at: http://projectweightloss.org

The Keto Kamp Podcast With Ben Azadi
#1126 What Really Happens When You Eat Nothing for 5 Days: The Truth About Fasting, Autophagy, and Cellular Healing With Ben Azadi

The Keto Kamp Podcast With Ben Azadi

Play Episode Listen Later Oct 14, 2025 22:27


In this episode, Ben Azadi, best-selling author of Keto Flex, shares the results of his five-day water fast — no food, no coffee, no shakes, only water and minerals. What began as a personal experiment turned into a deep physical, mental, and spiritual transformation. Ben walks you through what happens inside the body at each stage of fasting — from autophagy and ketone productionto dopamine reset, stem cell regeneration, and immune system renewal. You'll learn how fasting can help you heal, boost focus, enhance energy, and even reset your relationship with food. He also explains exactly how to break a long fast safely, when women should fast based on their cycle, and how to prepare your body for success.

Authentic Biochemistry
IS III 09October25 Authentic Biochemistry Podcast Dr Daniel J Guerra

Authentic Biochemistry

Play Episode Listen Later Oct 9, 2025 81:10


ReferencesNeuroscience, 2023-11-21, Volume533, Pages 22-35Autophagy. 2021 Dec;17(12):3992-4009Cell Death Discovery 2024.  volume 10, Article number: 200 Autophagy. 2022 Apr;18(4):726-744Guerra, DJGPhD. 2025. Unpublished LecturesRafferty, J. 1977.Baker Street.https://music.youtube.com/watch?v=Fo6aKnRnBxM&si=lYDwqknKv1Du18CrSimon, P. 1963 Bleeker St. from Wed Morning 3AM; lp. Simon and Garfunkelhttps://music.youtube.com/watch?v=xcXoGTACMHA&si=Wr55-ahAtcayIAPGPrine, J. 1971. Hello in Therehttps://music.youtube.com/watch?v=RfwGkplB_sY&si=l-PjfRcedC67wFg-John, E.1972. Mona Lisas and Madhattershttps://music.youtube.com/watch?v=feMawHOpamI&si=c_1Cbf5YJIx8cJMj

Fast Keto with Ketogenic Girl
New Study! Belly Fat Drops Faster on High-Protein — With Autophagy Still Active

Fast Keto with Ketogenic Girl

Play Episode Listen Later Oct 3, 2025 53:14


Beat BLOAT & unlock better protein absorption and digestion with MassZymes by BiOptimizers. NOW GET 15% off your order with the code VANESSA at bioptimizers.com/vanessa In today's solocast, we break down a brand new clinical trial that tested whether a high-protein diet really shuts down autophagy — and what it means for fat loss and body composition. For years, many believed that eating more protein would block the body's cellular clean-up process, and that only low-protein fasting diets could deliver longevity benefits. But does the science actually back that up? This new randomized controlled trial put high-protein and low-protein diets head-to-head, measuring weight loss, belly fat, metabolic health, and markers of autophagy. The results may surprise you — and they could change how we think about protein for fat loss and longevity. Timeline Mitopure Gummies — The #1 Urolithin A supplement for energy and healthy aging, now in delicious strawberry gummies. Get 20% off at timeline.com/vanessa We'll explore: Why autophagy matters for health and aging How the trial compared high vs. low protein under calorie restriction What the researchers found on belly fat, IGF-1, and cellular clean-up What this means for your fat loss and body recomposition goals IQBAR — Brain + body nutrition bars with high protein and clean ingredients. Get 20% off all products by texting VANESSA to 64000. Get my NEW high-protein keto guide: The Keto Reset eBook Learn more about the TONE LUX Crystal red light therapy mask and the accessory the TONE LUX CONTOUR for the neck and décolleté and get 20% OFF with the code VANESSA Free high-protein keto guide: The Keto Reset eBook

The Game Changing Attorney Podcast with Michael Mogill
402. How to Hack Your Biology for an Unfair Edge with Dave Asprey [Encore Edition]

The Game Changing Attorney Podcast with Michael Mogill

Play Episode Listen Later Sep 30, 2025 49:31


What if the biggest advantage in business and life is not money, strategy, or luck, but the way you fuel and control your own biology? In this encore episode of The Game Changing Attorney Podcast, Michael Mogill sits down with Dave Asprey, widely known as the father of biohacking. From shedding 100 pounds after years of failed diets to reversing early signs of aging, Dave has invested millions into understanding how the human body really works and how to bend those rules in your favor. You will hear how fasting, neuroscience, and high-ROI health practices can help you eliminate brain fog, unlock consistent energy, and give you a competitive edge that others cannot match. Here's what you'll learn: Why fasting sharpens your mind and boosts energy How to measure the ROI of daily habits The biohacks top performers use to stay ahead If you want the unfair edge in business and life, it starts with mastering your biology. ---- Show Notes: 02:35 – The struggle with weight, brain fog, and failed diets that started it all 04:57 – Discovering that most health advice is dogma, not science 05:58 – The “bulletproof” state and how abundant energy changes everything 08:49 – Fasting explained and why it matters for focus and resilience 10:22 – Intermittent fasting as a path to metabolic resilience 13:50 – Autophagy, cellular repair, and why most people run on limited energy 18:20 – The three biological drivers that steal focus: fear, food, and fertility Links & Resources: WHOOP Eight Sleep LeBron James Michael Phelps Intermittent fasting Bulletproof ---- Do you love this podcast and want to see more game changing content? Subscribe to our YouTube channel. ---- Past guests on The Game Changing Attorney Podcast include David Goggins, John Morgan, Alex Hormozi, Randi McGinn, Kim Scott, Chris Voss, Kevin O'Leary, Laura Wasser, John Maxwell, Mark Lanier, Robert Greene, and many more. ---- If you enjoyed this episode, you may also like: 364. How to Train Your Brain for Unbelievable Success 323. James Lawrence — The Power of One More: A Journey of Grit and Determination 293. Elite Athletes — The Mental Edge: How Champions Overcome The Impossible

The Keto Kamp Podcast With Ben Azadi
#1104 The World's Easiest 14-Day Fasting Plan to Melt Visceral Fat, Boost Autophagy, and Unlock Metabolic Freedom With Ben Azadi

The Keto Kamp Podcast With Ben Azadi

Play Episode Listen Later Sep 18, 2025 18:38


Ben reveals a beginner-friendly fasting schedule designed to melt harmful visceral fat in just 14 days. You'll learn how to safely progress from a 14:10 fasting window to a full 24-hour water fast, while supporting your metabolism, lowering inflammation, and activating autophagy for deep cellular repair. Ben also shares what to eat during your eating windows, how to break a fast properly, and simple hacks like coffee with butter or green tea to supercharge your results. Discover why visceral fat is so dangerous, the science of ketones and human growth hormone, and how fasting can become your most powerful tool for fat loss and longevity. Resources Mentioned: ✨Free Fat Loss Masterclass: Reserve your spot at http://meltyourfat.com  ✨Organic Coffee: http://ketokampcoffee.com  ✨Green Tea: https://amzn.to/4nGOgAV

DiversifyRx
Fasting Mimicking Diet: Benefits for Weight Loss, Health, and Longevity

DiversifyRx

Play Episode Listen Later Sep 17, 2025 49:58


**In this video, L-Nutra experts discuss the benefits of the L-Nutra Fasting Mimicking Diet (FMD) for improving longevity and metabolic health. Renee, a registered dietitian, explains how the five-day FMD program triggers autophagy, the body's natural cellular cleanup process, using specific foods and supplements. Dr. Shu shares clinical research showing that FMD can reduce biological age by 2.5 years, decrease insulin resistance by 59%, and promote weight loss without muscle loss.** **Show Notes:** 1. **Introduction and Purpose of the Meeting** [0:00] 2. **Renee's Introduction and Background** [1:24] 3. **Explanation of Fasting Mimicking Diet** [3:57] 4. **Autophagy and Its Benefits** [6:07] 5. **Details of the Fasting Mimicking Program** [10:10] 6. **Q&A and Practical Application** [12:08] 7. **How To Signup** [14:35] 8. **Research and Credibility** [10:10] 9. **Clinical Evidence and Benefits** [21:02] 10. **Implementation and Practical Tips** [45:53] 10. **Conclusion and Next Steps** [46:07] **Links mentioned in this episode:** [How To SignUp] rfitton@l-nutra.com  www.l-nutra.com  Websites Mentioned: https://www.drlisafaast.com/ https://diversifyrx.com/weekly-awesomeness-newsletter/  ----- #### **Becoming a Badass Pharmacy Owner Podcast is a Proud to be Apart of the Pharmacy Podcast Network**

FX Medicine Podcast Central
Andropause: Beyond Testosterone Decline with Emma Sutherland and Dr Leah Hechtman

FX Medicine Podcast Central

Play Episode Listen Later Sep 15, 2025


Dr Leah Hechtman, one of Australia's most respected naturopathic educators, joins fx Medicine by BioCeuticals ambassador Emma Sutherland to discuss the often-overlooked stage of men's health: andropause. More than simply “low testosterone,” andropause reflects age-related changes including Leydig cell decline, metabolic changes, vascular shifts, and neurological alterations that shape male wellbeing across the lifespan. Leah outlines how andropause may present in practice, from body composition changes and hair greying to mood shifts, sleep disruption, prostate dysfunction, and reduced cognitive performance. She highlights the importance of comprehensive testing — extending beyond testosterone — to include oestrogen, progesterone, follicle-stimulating hormone (FSH), luteinising hormone (LH), insulin, leptin, insulin-like growth factor-1 (IGF-1), and DUTCH hormone analysis. These insights allow clinicians to identify early signs and develop a more complete picture of male ageing. The discussion also explores strategies that may support resilience, including optimising sleep, managing stress, and addressing metabolic health. Useful complementary medicines include nutritional considerations such as nicotinamide riboside, bioflavonoids, and zinc, as well as herbal medicines including ginkgo, grape seed extract, ashwagandha, and tribulus. The role of prostate health and testosterone therapy is also discussed. Covered in this episode: (01:01) Welcome Leah Hechtman (02:22) What is andropause? (05:16) Testosterone production and ageing (09:55) Andropause symptoms (14:28) Infertility (20:28) Autophagy, ageing and reproductive disorders (24:23) Obesity and sleep (30:53) Stress and testosterone (32:24) Prostate cancer (36:37) Erectile dysfunction (39:51) Testosterone replacement therapy (TRT) (44:37) Intermittent fasting (48:00) Testosterone receptor sensitivity (50:42) Final remarks Find today's transcript and show notes here: https://www.bioceuticals.com.au/education/podcasts/andropause-beyond-testosterone-decline Sign up for our monthly newsletter for the latest exclusive clinical tools, articles, and infographics: www.bioceuticals.com.au/signup/ FX DISCLAIMER: The information provided on fx Medicine by BioCeuticals is for educational and informational purposes only. The information provided is not, nor is it intended to be, a substitute for professional advice or care. Please seek the advice of a qualified health care professional in the event something you learn here raises questions or concerns regarding your health.

The MindBodyBrain Project
Unpacking Longevity and Cellular Health: A Conversation with Dr. Jon Brudvig - Part Two

The MindBodyBrain Project

Play Episode Listen Later Sep 12, 2025 41:57 Transcription Available


Here is the second part of my conversation with biochemist Jon Brudvig to delve into the fascinating world of longevity and contemporary health interventions. We tackle topics ranging from SGLT2 inhibitors and their unexpected benefits to the controversial nature of microplastics in our environment. This dialogue is a treasure trove for anyone interested in the intersections of health, science, and longevity. What You'll Learn: Exploring SGLT2 Inhibitors: Discover the multifaceted benefits of SGLT2 inhibitors, originally diabetes drugs, for heart, kidney, and possibly cognitive health. Metformin: A Mixed Bag: Get an overview of the metformin debate, examining its potential benefits and the contentious nature of the research. Fasting Fundamentals: Gain insights into intermittent fasting, its impact on metabolism, potential benefits, and the critical role of resistance training to mitigate muscle loss. Microplastics: An Underestimated Threat: Learn about the insidious presence of microplastics in human tissues and their potential health repercussions. Potential Interventions: Hear about experimental approaches to reducing microplastics in the body, including the potential role of sulforaphane. Key Takeaways: SGLT2 inhibitors: These drugs have shown promising longevity benefits beyond their initial purpose for diabetes management. Metformin's Controversy: While some data suggests potential longevity benefits, criticism exists regarding its exercise interference and study methodologies. The Role of Fasting: Intermittent fasting can be beneficial, particularly for metabolic health, but must be carefully balanced with nutritional needs and physical activity. Microplastics Concern: Ubiquitous in the environment, microplastics are potentially linked to inflammation and adverse health outcomes, necessitating further research and interventions. Self-Experimentation: Personal health experiments, like those done by Jon Brudvig, highlight the importance of understanding one’s own biology in response to health interventions. Resources: Connect with Dr. Jon Brudvig for more insights into longevity and health: LinkedIn: Jon Brudvig Substack: https://jonbrudvig.substack.com/ Support the Podcast: If you found this episode valuable, please consider subscribing to our podcast and leaving a review. Your feedback helps us continue bringing important conversations like these to a wider audience. Whether you're driven by personal health challenges or broader scientific curiosity, this conversation provides a unique peek into the current and future possibilities of living healthier, longer lives. Share this with individuals passionate about health and longevity, and join the ongoing dialogue to advance our understanding and well-being. 00:12 Understanding SGLT2 Inhibitors 02:51 Mendelian Randomization and SGLT2 Inhibitors 06:24 Benefits and Mechanisms of SGLT2 Inhibitors 09:47 Discussion on Metformin 14:36 Intermittent Fasting and Ketone Supplements 17:46 Fasting, Autophagy, and Muscle Health 22:38 Exploring Glycine and N-Acetyl Cysteine 24:48 Microplastics: A Growing Concern 26:25 The Impact of Microplastics on Health 31:54 Self-Experimentation with Sulforaphane 38:33 Final Thoughts and Future Work See omnystudio.com/listener for privacy information.

The Red Light Report
Q&A on Mitochondrial Health w/ Dr. Mike Belkowski & Don Bailey

The Red Light Report

Play Episode Listen Later Sep 11, 2025 53:34


In this week's episode of The Energy Code, Dr. Mike Belkowski is joined by Don Bailey, CMO of BioLight, for an engaging and informal Q&A session diving deep into the fundamentals of mitochondrial health. This episode marks a return to the podcast's roots, offering a conversational exploration of why mitochondria are the key to unlocking limitless vitality and how to optimize their function for energy, longevity, and resilience. Dr. Mike and Don discuss the critical role of mitochondria as the powerhouse of the cell, the impact of environmental factors on energy production, and practical strategies to enhance mitochondrial efficiency. From sunlight exposure and circadian alignment to the synergistic benefits of red light therapy and methylene blue, this episode provides both a big-picture understanding and actionable insights for listeners at any stage of their health journey. Expect a blend of science, practical tips, and personal anecdotes as Don shares his transformative experience with BioLight's protocols and Dr. Mike breaks down complex mitochondrial concepts into accessible, impactful knowledge. Key Topics Covered: Why energy is the foundation of health and longevity The role of mitochondria as environmental sensors and energy producers How redox potential and electron flow impact cellular health The dangers of non-native EMFs, blue light, and chronic stress on mitochondrial function The synergistic effects of red light therapy and methylene blue for brain health and energy The connection between mitochondrial dysfunction, aging, and disease Autophagy and mitophagy: clearing out “zombie cells” for cellular renewal The importance of circadian biology and morning sunlight for mitochondrial optimization How food choices and environmental mismatch affect mitochondrial performance Key Quotes from Dr. Mike: “The more energy you produce per cell, the healthier you are. The less energy, the closer you are to disease or even cancer.” “Mitochondria are environmental sensors, reading the light in your food and the signals in your environment.” “Sunlight exposure is free and sets the stage for better sleep, better energy, and better mitochondrial function.” “Chronic stress is a mitochondrial toxin — it fries your biology at both ends of the candle.” Key Quotes from Don Bailey: “When I experienced the benefits of methylene blue and red light therapy, I knew I had to help others feel this too.” “My entire family is using these tools, and the energy output we're experiencing is phenomenal.” Episode Timeline: 00:00 – Welcome + introduction to the Q&A format with Don Bailey 01:30 – Don's journey with BioLight and the impact of red light therapy and methylene blue 05:37 – Why energy is the core of health and vitality 09:50 – Mitochondria: beyond the “powerhouse of the cell” 13:02 – Mitochondrial density in organs like the brain and heart 15:08 – Methylene blue as a mitochondrial booster and its synergy with red light therapy 20:00 – Understanding redox potential and electron flow in the body 23:36 – How non-native EMFs and poor environments lower redox potential 26:31 – Environmental disruptors: blue light, stress, and lack of movement 29:07 – The demonization of sunlight and its impact on health 30:00 – Calcium signaling and mitochondrial dysfunction 32:05 – Mitochondrial health and its direct link to aging 33:48 – Autophagy, mitophagy, and the rise of “zombie mitochondria” 39:47 – Can mitochondrial dysfunction be organ-specific? 42:13 – How food's light imprint affects mitochondrial function 45:14 – Low energy and fatigue as signs of mitochondrial dysfunction 48:35 – Practical tip: morning sunlight for circadian and mitochondrial health 51:07 – Stress reduction as a cornerstone of mitochondrial optimization 52:01 – Closing thoughts and plans for a part-two episode Resources & References: Dr. Doug Wallace on mitochondrial bioenergetics Dr. Jack Kruse on circadian biology and EMFs BioLight's BioBlue enhanced methylene blue product The Mitochondriac Manifesto 2 by R.D. Lee Quantum Return to Nature Retreat with Oksana Hanson and Carrie Bennett   Special Offer: ⚡️ LIMITED TIME DISCOUNT ON BIOBLUE! ⚡️ Boost your mitochondrial function with BioLight's BioBlue! BioBlue amplifies the benefits of red light therapy and targets metabolically dysfunctional cells, especially in the brain.   Order BioBlue today and save 15% on any quantity (single, double, four, or ten packs)! Use coupon code BIOBLUE15 at checkout. For larger quantities, enjoy even greater discounts.   Discount code: BIOBLUE15   Expires: Thursday, 9/18, midnight PST   Check out BioBlue, CLICK HERE!   Stay Connected: Dr. Mike Belkowski: Instagram: @dr.mikebelkowski LinkedIn: Dr. Mike Belkowski Facebook: Mike Belkowski Don Bailey: X: @DonBaileySpeaks BioLight: Website | Instagram | Facebook Final Note: If you enjoyed this episode, share it with a friend or family member to spread the word about mitochondrial health. Leave a five-star rating and review to help The Energy Code reach more listeners. Stay tuned for part two, where Dr. Mike and Don will dive deeper into practical strategies for optimizing mitochondrial function!

Post Concussion Syndrome Awareness Podcast
Episode 62: Kim Birkhimer & Blaine Benson Return!

Post Concussion Syndrome Awareness Podcast

Play Episode Listen Later Sep 11, 2025 82:40


Blessed & Grateful to have a 3rd podcast chat with Kim & Blaine from Idaho USA. SO VERY blessed to have a second podcast out this week, this time with the amazing Kim Birkhimer and Bman Ben back to join me from Idaho USA for the 3rd time!In this 62nd episode we cover Neurofeedback, Aphasia, Oxidative stress, Nicotinamide, Fasting, Autophagy and much more...The cause for recovery from Traumatic Brain Injury continues...Kim's Links Here:https://pubmed.ncbi.nlm.nih.gov/?term=Protandim https://kimbirkhimer.lifevantage.com/us-en/?validatedhttps://kimbirkhimer.lifevantage.com/uk-en/https://kimbirkhimer.lifevantage.com/ca-en/https://kimbirkhimer.lifevantage.com/au-en/https://kimbirkhimer.lifevantage.com/nz-en/https://kimbirkhimer.lifevantage.com/nl-nl/https://neuroptimal.com/ pubmed.ncbi.nlm.nih.gov

Intelligent Medicine
Leyla Weighs In: Advances in Alzheimer's Detection and Prevention

Intelligent Medicine

Play Episode Listen Later Sep 5, 2025 23:59


Nutritionist Leyla Muedin discusses recent advancements in the detection and prevention of Alzheimer's disease. Topics include the new FDA-approved Lumipulse blood test, the role of a ketogenic diet in improving mitochondrial health, and the significance of lifestyle changes such as social and cognitive activities. The episode also highlights promising research from the University of California Irvine on using natural compounds like nicotinamide and EGCG to rejuvenate aging brain cells and address the buildup of Alzheimer's-associated proteins. Leyla also provides insights into the difference between Alzheimer's and general dementia and emphasizes the importance of accurate diagnosis and appropriate treatments.

The MindBodyBrain Project
Unpacking Longevity and Cellular Health: A Conversation with Dr. Jon Brudvig - Part One

The MindBodyBrain Project

Play Episode Listen Later Sep 5, 2025 40:46 Transcription Available


In a fascinating and insightful discussion, I sat down with Dr. Jon Brudvig, a medical scientist and expert in neuroscience and drug development. Together, we explored the science of aging, the critical role of cellular recycling, and the practical steps anyone can take to improve their healthspan. Jon Brudvig shared his journey from rare disease research to longevity science, offering actionable insights into how our daily choices impact the aging process. Such a good conversation, I have split it into two parts. What You'll Learn: The Cellular Foundation of Aging:Discover how Dr. Brudvig’s research into lysosomal storage diseases led him to understand the universal decline in cellular recycling (autophagy and lysosomal function) as a key driver of aging. Autophagy Explained:Learn why autophagy—the body’s process of breaking down and recycling damaged cellular components—is essential for health, and how modern lifestyles can disrupt this natural cycle. The Fundamentals of Longevity:Understand why exercise, diet, sleep, vitamin D, omega-3s, and real-life social connections are the true building blocks of a long and healthy life. Mouse Models and Human Longevity:Gain perspective on the limitations of animal studies in longevity research, and why findings in mice don’t always translate directly to humans. The mTOR Pathway and Protein Intake:Explore the debate around the mTOR pathway, protein consumption, and how balancing periods of growth and rest may be the key to optimal aging. Healthspan vs. Lifespan:Reflect on the difference between living longer and living better, and why increasing your years of good health (healthspan) is a more realistic and valuable goal than chasing extreme longevity. Key Takeaways: Aging is cellular: The decline in lysosomal and autophagy function is a core driver of aging and disease. Autophagy matters: Fasting, exercise, and periodic stressors help trigger the body’s natural recycling processes. Master the basics: Exercise, a balanced diet, quality sleep, and strong social ties are the most effective longevity interventions. Be cautious with quick fixes: Not all supplements or drugs that work in mice will work in humans—focus on proven fundamentals first. Balance is key: Intermittent activation of growth pathways (like mTOR) through meals and exercise, balanced with periods of rest, supports healthy aging. Protein quality counts: Mix your protein sources and prioritise whole foods for optimal health outcomes. Connect with Dr. Jon Brudvig for more insights into longevity and health: LinkedIn: Jon Brudvig Substack: https://jonbrudvig.substack.com/ 00:53 Dr. Brudvig’s Background and PhD Focus01:22 Gene Therapy and Lysosomal Storage Diseases02:45 Connecting Rare Diseases to Aging03:10 Lysosomal Function and Aging03:40 Professional Work in Drug Development04:01 The Link Between Professional and Personal Interests04:22 The Role of Lysosomes in Autophagy04:40 What is Autophagy?04:54 Why Autophagy Matters for Cellular Health05:07 The Recycling Analogy: Cells as Master Recyclers05:26 Evolutionary Importance of Autophagy06:14 Autophagy, Fasting, and Modern Lifestyles07:07 The Impact of Modern Comfort on Health07:28 Social Media, Longevity, and Biohacks08:00 The Interventions Testing Program Explained08:42 Mouse Studies and Their Limitations09:32 The Importance of Fundamentals: Exercise, Diet, Sleep10:22 Omega-3s and Social Networks for Longevity11:00 The Hallmarks of Aging11:40 Homeostasis and the Aging Process12:20 Healthspan vs. Lifespan: Which Matters More?13:07 The Two Camps in Longevity Science13:51 Promising Interventions: SGLT2 Inhibitors and Rapamycin14:45 Rapamycin: Hype, Dosing, and Human Application15:53 mTOR Pathway, Protein Intake, and Longevity17:00 Balancing mTOR Activation and Autophagy18:00 Practical Protein Advice: Whey, Collagen, and Plant-Based Sources18:45 Final Thoughts: Eat Real Food and Mix Protein Sources See omnystudio.com/listener for privacy information.

NutritionFacts.org Video Podcast
Does Coffee Help Boost Autophagy and Lifespan?

NutritionFacts.org Video Podcast

Play Episode Listen Later Sep 1, 2025 5:14


In terms of longevity, three cups of decaf coffee appeared to be just as protective as three cups of regular coffee.

Fast. Feast. Repeat.  Intermittent Fasting For Life
Episode 113: More than Weight Loss, The Taste of Ketosis, Autophagy & Skin, and More

Fast. Feast. Repeat. Intermittent Fasting For Life

Play Episode Listen Later Aug 27, 2025 55:08 Transcription Available


Welcome to this week's episode of Fast. Feast. Repeat. Intermittent Fasting for Life, with Gin Stephens and Sheri Bullock.To make a submission for the podcast, go to fastfeastrepeat.com/submit.  We are a community-driven podcast, and we look forward to sharing your questions, success stories, non-scale victories, IF tweaks, motivational quotes (and more!) on each episode of the podcast. Resources used in today's episode: For personal IF coaching email Sheri:  sheri@fastfeastrepeat.com https://www.fastfeastrepeat.com/sheri.html  https://crunchi.com/?als=SheriBullock Gin has a new YouTube Channel!  Visit https://www.youtube.com/channel/UC_frGNiTEoJ88rZOwvuG2CA and subscribe today so you never miss an intermittent fasting tip, a support session, or an interview with a past IF Stories guest or expert.Want to learn more about BiOptimizer's Magnesium Breakthrough? Visit www.bioptimizers.com/fastfeastrepeat and use code FFR10 to save 10% off any order. Go to fastfeastrepeat.com to see Gin's and Sheri's favorite things, and to shop with us.  Every purchase you make through links on our website help to support this podcast so we can keep bringing you episodes each week. Are you ready to take your intermittent fasting lifestyle to the next level? There's nothing better than community to help with that.  In the Delay, Don't Deny community we all embrace the clean fast, and there's just the right support for you as you live your intermittent fasting lifestyle. Connect with both Gin and Sheri in the community, as well as thousands of other intermittent fasters who are there to support you along your journey.  If you're new to intermittent fasting or recommitting to the IF lifestyle, join the 28-Day FAST Start group.  After your fast start, join us for support in The 1st Year group.  Need tips for long term maintenance? We have a place for that!  There are many more useful spaces beyond these, and you can interact in as many as you like.Visit ginstephens.com/community to join us. An annual membership costs just over a dollar a week when you do the math.  If you aren't ready to fully commit for a year, join for a month and you can cancel at any time. If you know you'll want to stay forever, we also have a lifetime membership option available.  IF is free. You don't need to join our community to fast. But if you're looking for support from a community of like-minded IFers, we are here for you at  ginstephens.com/community.

Burn it Nutrition Podcast
Ep184: Fasting Beyond Weight Loss: Autophagy, Loose Skin, and Lasting Transformation with Chris James

Burn it Nutrition Podcast

Play Episode Listen Later Aug 27, 2025 52:37


●     Fasting is the Answer ●       Pushing to Day 14 of Fasting ●       Preparing for an Extended Fast ●       How to Avoid Loose Skin ●       Activating Autophagy ●       Power of Structured Water ●       Mindset for an Extended Fast ●       Social Gatherings During a Fast ●       And so much more!   Links mentioned in this episode! Show notes page: https://burnitnutrition.com/podcast184/ . . .  LMNT – Get a free sample pack with your first order at https://drinklmnt.com/burnit . . BiOptimizers - Get Magnesium Breakthrough and 10% discount with code burnit   - http://bioptimizers.com/burnit . . Nutrisense- Get your Continue Glucose and use code BURNIT for 33% off your plan for the entire duration. Head to http://nutrisense.io/burnit . . Witness Mi - Get your Echo Memory Book and preserve your memories in an Ai generated video with your voice and likeness. Head to https://go.witnessmi.com/info-new . . Learn more about Chris James: Website: https://ahealthyalternative.org/  Community: https://www.ahacommunities.com/ IG: @A.Healthy.Alternative First 25 mention BURN for free metabolic reset call . . Podcast Shop Page for Best Deals at https://burnitnutrition.com/shop  . Leave me a rating & review on Apple Podcasts: https://itunes.apple.com/us/podcast/burn-it-nutrition-podcast/id1195955730?mt=2  . Follow Joseph Navarro on Instagram under @BurnitNutrition . Follow Joseph Navarro on Facebook under @BurnitNutrition . Thank You for Listening!! Please share this episode! Be the one who helps spark a transformation in your family! Feedback to share? Send email to info@BurnitNutrition.com Subscribe! Don't miss another episode! Notice of Sponsorship Affiliate Disclosure with BiOptimizers, LMNT, and Nutrisense Fair Use Disclaimer The following podcast episode contains audio clips that are used under the doctrine of fair use as defined by United States copyright law. These clips are used for purposes of commentary, criticism, news reporting, teaching, scholarship, and research. All rights to the original audio content remain with the respective copyright holders. This use is not intended to infringe upon their rights, but to enhance the discussion and understanding of the topic at hand. Please read the full medical disclaimer  burnitnutrition.com/medical-disclaimer/

Parkinson's Warrior Podcast
Can the Carnivore Diet Help Parkinson's Disease? | Ketosis, Brain Healing & Inflammation

Parkinson's Warrior Podcast

Play Episode Listen Later Aug 27, 2025 15:30


Could eating only meat actually help with Parkinson's Disease? In this episode (watch on YouTube), we explore the controversial and compelling carnivore diet—a 100% animal-based approach—and why some people with Parkinson's are turning to it for inflammation reduction, gut healing, and brain support. We cover: -How the carnivore diet may reduce neuro-inflammation -Why ketosis could be protective for dopamine-producing neurons -The connection between oxidative stress and Parkinson's progression -How ketones support cellular cleanup (autophagy) and mitochondrial function -Nutrients in animal-based diets that support brain and nerve health -Risks, cautions, and who this diet may NOT be right for Whether you're carnivore-curious or just exploring ways to optimize your Parkinson's care naturally, this episode dives into the “why” behind the trend. Be sure to enhance ketosis among other benefits with Dr. Blair's Beta-Caryophyllene products here (Use promo code PDEDUCATION at checkout to save 10%!!): https://www.blairmedicalgroup.shop/shop/bcplus-endocannabinoid-activation-products/2?aff=22 Learn how to use carnivore to help manage Parkinson's by exploring this course https://pdeducation.thinkific.com/products/courses/empowerhealing JUMPSTART protocol here: https://pdeducation.thinkific.com/products/digital_downloads/30dayjumpstart 

Born to Heal Podcast with Dr. Katie Deming
How Fasting and Diet Could Starve Cancer Cells with Dr. Thomas Seyfried, Author of "Cancer as a Metabolic Disease" and Researcher

Born to Heal Podcast with Dr. Katie Deming

Play Episode Listen Later Aug 26, 2025 74:56 Transcription Available


Access the FREE Water Fasting Masterclass Now: https://www.katiedeming.com/the-healing-power-of-fasting/What lifestyle choices can reduce your risk before cancer develops? (Video ReRelease)Dr. Katie Deming sat down with Dr. Thomas Seyfried, professor of biology at Boston College and author of Cancer as a Metabolic Disease. Together, they explore how cancer cells depend on sugar and glutamine for fuel, why the mitochondria, not DNA mutations, may be at the heart of the disease, and what this understanding means for prevention and treatment.Key Highlights:Can dietary changes, fasting, and exercise support treatment once cancer is diagnosed? Why should patients and doctors pay attention to the Glucose Ketone Index (GKI) to measure how the body is fueling itself?What can you do today to reduce your risk of chronic illness?Dr. Seyfried explains the Warburg Effect, the role of dysfunctional mitochondria in cancer growth, and why standard treatments may sometimes work against us by feeding cancer's energy needs.Listen, learn the surprising story of how weight loss, not a new drug, led to dramatic tumor reduction in lab studies. Dr. Thomas Seyfried: https://www.bc.edu/bc-web/schools/morrissey/departments/biology/people/faculty-directory/thomas-seyfried.htmlAccess the FREE Water Fasting Masterclass Now: https://www.katiedeming.com/the-healing-power-of-fasting/ Transform your hydration with the system that delivers filtered, mineralized, and structured water all in one. Spring Aqua System: https://springaqua.info/drkatieMORE FROM KATIE DEMING M.D. Save your spot for the next LIVE fasting call here: https://www.katiedeming.com/the-healing-power-of-fasting/ Work with Dr. Katie: www.katiedeming.comEmail: INFO@KATIEDEMING.COM 6 Pillars of Healing Cancer Workshop Series - Click Here to Enroll Follow Dr. Katie Deming on Instagram: https://www.instagram.com/katiedemingmd/ Please Support the Show Share this episode with a friend or family member Give a Review on Spotify Give a Review on Apple Podcast DISCLAIMER: The Born to Heal Podcast is intended for informational purposes only and is not a substitute for seeking professional medical advice, diagnosis, or treatment. Individual medical histories are unique; therefore, this episode should not be used to diagnose, treat, cure, or prevent any disease without consulting your healthcare provider.

The Fasting Method Podcast
Fasting Q&A with Dr Jason Fung: New 5-Day Fasting Reset, Bitter Greens, Body Set Weight, Kidney Damage, and More

The Fasting Method Podcast

Play Episode Listen Later Aug 19, 2025 37:33 Transcription Available


Episode #219 In this Fasting Q&A episode, hosted by Coach Lisa Chance, Dr. Jason Fung answers questions from the TFM Community: I realize the relationship between bitters, incretins, and autophagy is more complex than a direct cause-and-effect relationship. The incretin response doesn't directly “promote” autophagy - it primarily regulates blood sugar and satiety. Autophagy is mainly triggered by nutrient scarcity and low insulin levels, not by bitter compounds themselves.  Can you weigh-in on using bitter greens during this reset? [16:07]  I have had some success lowering weight a couple times using fasting and time restricted eating but the weight creeps back up after a while even with doing TRE. What's nice is that I can get it to go back down again with discipline. I'm wondering what scientific evidence exists that your body set weight can successfully be reset for the long term as mine holds for a while but then wants to creep up and if there's a foolproof method to resetting your body set weight? [19:26] Your kidney patients who are T2D and close to needing dialysis, but are skinny, I'm assuming they need to fast for about a year to reverse the kidney damage, but how do they do it with so little fat mass? [26:56]  I know that vitamin D is fat soluble and best taken with a meal. I've also heard that all supplements are better absorbed when taken with a meal. Is this true? What timeframe is considered “with a meal”? Is it before, during or after the meal? Is vitamin D a stimulant and can disrupt sleep so best taken in the morning? [30:32] How do you rate the risk of new gallstones formation if a patient already has one or more when it comes to fasting protocols? [33:46]   Links: Dr. Fung's YouTube video, 5 Ways to Naturally Boost the Ozempic Effect https://www.youtube.com/watch?v=le3Ifc7D5Vk&t=2s Gallstones discussed on TFM Podcast #171 https://www.thefastingmethod.com/fasting-qa-with-dr-jason-fung-gallstones-and-fasting-high-ketones-persistent-high-blood-sugar-and-more/   Please note that you need to be a member of the TFM Community to submit questions to the Q&A webinars with Dr. Fung but you can submit questions to our regular Q&A episodes here: https://bit.ly/TFMPodcastQs   Transcripts of all episodes are available on the Podcast page at www.thefastingmethod.com   Explore the TFM Community with a 7-Day FREE TRIAL https://www.thefastingmethod.com/community/   Book a complimentary 15-minute coaching intake assessment with one of the TFM coaches https://www.thefastingmethod.com/coaching/   Connect With Us Instagram: https://www.instagram.com/fastingmethod/ Facebook Page: https://www.facebook.com/TheFastingMethod Join our FREE Facebook Group: https://bit.ly/TFMNetwork   Summary Timestamps 00:00 Intro 01:49 Introducing TFM's new 5-Day Fasting Reset 16:07 Bitter greens 19:26 Body set weight 26:56 Reversing kidney disease possible? 30:32 Timing of taking fat-soluble vitamins 30:32 Gallstones   Disclaimer This podcast is for educational purposes only and is not a substitute for professional care by a doctor or other qualified medical professional. You should always speak with your physician or other healthcare professional before doing any fasting, changing your diet, taking or adjusting any medication or supplements, or adopting any treatment for a health problem. The use of any other products or services purchased by you as a result of this podcast does not create a healthcare provider-patient relationship between you and any of the experts affiliated with this podcast. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease.

The Sleep Is A Skill Podcast
223: Dr. Alexis Cowan, Princeton-Trained PhD, Circadian, & Metabolism Scientist: The Missing Link Between Metabolism, Light, and Deep Sleep

The Sleep Is A Skill Podcast

Play Episode Listen Later Aug 15, 2025 66:20


BIO:Dr. Alexis Cowan is a Princeton-trained PhD whose interests and specialities lie at the intersection of circadian and photobiology, metabolism, and the microbiome. After completing her doctoral research in one of the top metabolism labs in the world, she started her private practice where she works with athletes and highly motivated individuals looking to optimize their health and performance as well as health coaches and professionals looking to expand the repertoire of tools in their toolkits. SHOWNOTES:

Dr. Berg’s Healthy Keto and Intermittent Fasting Podcast
What Happens If You Don't Eat For 5 Days?

Dr. Berg’s Healthy Keto and Intermittent Fasting Podcast

Play Episode Listen Later Aug 14, 2025 15:48


On day 1 of fasting, glycogen is eliminated from the body. Your insulin drops on your first day of fasting, allowing you to tap into your fat reserve. Electrolytes, trace minerals, and B vitamins can be very beneficial during prolonged fasting, especially if you haven't built up a reserve of these nutrients. You can drink tea and coffee without cream or sugar and have water with lemon during your 5-day fast. Plenty of sun, long walks in nature, hot and cold therapy, and HIIT can also enhance the benefits of prolonged fasting. On day 2 of prolonged fasting, you get deeper into ketosis, which means your body burns fat for energy. Autophagy typically begins on the second day of prolonged fasting. This is the process in which the body recycles damaged proteins and uses them for fuel and new tissues. On day 3, brain function and mood continue to improve. BDNF is stimulated, which helps support brain cell regeneration and increases your learning capacity. You also enter a state of deep autophagy, which helps repair mitochondrial damage and clean up intracellular pathogens. On day 3 of a prolonged fast, your immune system essentially resets.Prolonged fasting supports the growth of the thymus gland and allows the gut lining to regenerate completely. People often experience a massive spike in growth hormone on day 3, which protects against muscle loss.On day 4, hunger is gone, and maximum fat burning occurs! Bone broth can be beneficial if you're struggling through a 5-day fast or experiencing a stressful event. Longevity and protective genes are heightened, and your antioxidant networks are strengthened during prolonged fasting. It can also help diversify your microbiome. Slowly begin the refeeding process with around ¼ of your typical calories. Try an egg with sauerkraut, and then wait a few hours before consuming something like a small amount of soup with avocado. After a few more hours, consume berries and nuts. Wait before introducing a full meal and avoid sugar and carbohydrates. High-quality food is vital at this time!After a 5-day fast, your skin, muscles, joints, and brain will show significant improvements! Regular intermittent fasting can help prepare you for a 5-day fast. Dr. Eric Berg DC Bio:Dr. Berg, age 60, is a chiropractor who specializes in Healthy Ketosis & Intermittent Fasting. He is the Director of Dr. Berg Nutritionals and author of the best-selling book The Healthy Keto Plan. He no longer practices, but focuses on health education through social media.

Myers Detox
How to Use Fasting to Fix Inflammation, Burn Fat, and Restore Energy Naturally With Dr. David Jockers

Myers Detox

Play Episode Listen Later Jul 31, 2025 62:12


There's a reason more and more people are turning to intermittent fasting as a reset button for the body. In this episode, I sit down with Dr. David Jockers to unpack what might be the most underrated survival mechanism built into our cells: autophagy. It's a cleanup crew that breaks down damaged mitochondria, clears out zombie cells, and even resets your gut microbiome. If your energy crashes midday, if your cravings hit hard at night, or your body feels inflamed and sluggish no matter what you eat, there's a good chance your cells aren't getting the cleanup time they desperately need. And that starts with insulin staying too high, too often. We talk about how to train your body to burn fat effortlessly, how long it takes to start getting results from fasting, and why most people are unknowingly blocking this cellular self-repair system. Dr. Jockers also shares how to make fasting easier and safer, especially if you've struggled with low energy or headaches. He also explains why you should consider binders during a fast, how to recognize when your mitochondria are stressed out, and the brain-boosting effects of ketones once you hit day three of a longer fast.   "Just like we talk about a vitamin D deficiency or a zinc deficiency, autophagy is like an essential nutrient. You have to go through it to be healthy." ~ Dr. David Jockers   In This Episode: - What is autophagy, and why is it essential? - How to start fasting - Tips for longer fasts and what to include - How ketones reduce inflammation and boost brain health - Are ketone supplements worth it? - Juice and bone broth fasting - Using binders and other protocols to manage detox symptoms during a fast - Fasting's impact on gut microbiome diversity - The link between fasting, clearing of "zombie cells," and longevity   Products & Resources Mentioned: Conquering Chronic Inflammation Summit 2.0: Learn more here https://drtalks.com/summit/conquering-inflammation/  Bon Charge Red Light Face Mask: Use code WENDY to get 15% off at https://boncharge.com  Fresh-Pressed Olive Oil: Try a full-size $39 bottle for just $1 to cover shipping at https://getfreshwendy.com  Heavy Metals Quiz: Start at https://heavymetalsquiz.com   About Dr. David Jockers: Dr. David Jockers is a doctor of natural medicine and a world-renowned expert in metabolic health, fasting, and functional nutrition. He runs one of the most popular natural health websites, DrJockers.com, which gets over a million monthly visitors. Dr. Jockers is the author of the bestselling books The Keto Metabolic Breakthrough and The Fasting Transformation, and he hosts the Dr. Jockers Functional Nutrition podcast, consistently ranked as one of the top health and fitness podcasts. Learn more at: https://drjockers.com/  Disclaimer The Myers Detox Podcast was created and hosted by Dr. Wendy Myers. This podcast is for information purposes only. Statements and views expressed on this podcast are not medical advice. This podcast, including Wendy Myers and the producers, disclaims responsibility for any possible adverse effects from using the information contained herein. The opinions of guests are their own, and this podcast does not endorse or accept responsibility for statements made by guests. This podcast does not make any representations or warranties about guests' qualifications or credibility. Individuals on this podcast may have a direct or indirect financial interest in products or services referred to herein. If you think you have a medical problem, consult a licensed physician.

The Peter Attia Drive
#353 - AMA #72: Fasting: benefits for body composition and disease prevention, potential risks, and Peter's updated practical framework

The Peter Attia Drive

Play Episode Listen Later Jun 16, 2025 19:51


View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this “Ask Me Anything” (AMA) episode, Peter revisits the topic of fasting, sharing how his thinking has evolved over time. The episode explores fasting-related terminology and common types of fasting, as well as the various reasons individuals might choose to fast. Peter explores potential benefits including improvements in body composition, metabolic health, lifespan extension, cardiovascular disease, cancer prevention and treatment, neurodegenerative conditions such as Alzheimer's and Parkinson's, and autoimmune symptoms like arthritis. He also examines the risks and potential downsides of fasting and offers a practical framework to help assess when and how fasting may be most appropriately applied. If you're not a subscriber and are listening on a podcast player, you'll only be able to hear a preview of the AMA. If you're a subscriber, you can now listen to this full episode on your private RSS feed or our website at the AMA #72 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here. We discuss: Why the topic of fasting is being revisited [1:45]; The importance of being open to changing one's opinion in science and medicine as new evidence emerges [4:15]; Defining fasting and how it fits in the framework of dietary restriction, time-restricted feeding, and calorie restriction [7:30]; The most common types of fasting [11:45]; Why someone might choose fasting over continuous caloric restriction [19:00]; The biochemical effects of fasting: fuel partitioning, autophagy, and more [21:00]; Autophagy: a cellular cleanup process stimulated by fasting and energy depletion [26:00]; Comparing the physiological effects of a ketogenic diet to those of long-term fasting [27:45]; How long fasting takes to induce ketosis and boost autophagy, and how autophagy is measured [29:45]; At-home tests for ketones [33:45]; Reducing senescent (“zombie”) cells and inflammation through autophagy [35:00]; Examining the evidence for the long-term health benefits of fasting beyond short-term metabolic effects [37:15]; The common health claims associated with fasting across metabolic, neurological, oncological, autoimmune, and longevity domains [40:30]; The impact of fasting on body weight and body composition [42:00]; Weight regain and potential metabolic consequences of fasting [44:00]; The risk of lean mass loss with fasting and how to mitigate it [47:15]; A practical framework for using fasting as a strategy to improve body composition [52:15]; How extended fasting compares to caloric restriction in improving insulin sensitivity in people with insulin resistance or type 2 diabetes [54:00]; Is there any evidence that fasting can extend lifespan? [55:45]; Examining whether fasting improves cardiovascular disease risk beyond the effects of weight loss and calorie reduction [58:15]; Exploring whether prolonged fasting can reduce cancer risk [59:45]; The potential benefits of fasting or fasting-mimicking diets during cancer treatment: emerging evidence and practical considerations [1:02:15]; Fasting for protection against neurodegenerative diseases: early evidence of therapeutic benefit and open questions [1:10:45]; Various fasting methods for autoimmune diseases: potential symptom relief with cautious application [1:14:00]; Fasting and type 1 diabetes: risks, evidence, and careful dietary alternatives [1:16:45]; Fasting and gut disorders: potential benefits outside of flare-ups [1:18:45]; The primary risks and downsides associated with fasting [1:19:45]; The essential vitamins and minerals to supplement during prolonged fasting [1:21:30]; Who should avoid fasting and why [1:22:15]; Fasting's role in health: where it shows promise and where it likely offers no distinct advantage over caloric restriction [1:23:45]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube