Cellular catabolic process in which cells digest parts of their own cytoplasm
Today, I am blessed to have here with me Dr. Gonzalez. He obtained his Ph. D and BS from the University of California, Irvine where he studied, and his thesis addressed interactions of the immune system following spinal cord injury. In addition to his expertise in degenerative disorders involving the spinal cord, he has extensive experience in stem cell culture and biology from various sources. He has extensive knowledge in all aspects of cell biology and health where he teaches worldwide on regenerative medicine and maintaining immune health. This episode originally aired in August 2021. Dr. Gonzalez is responsible for the development of clinical stem cell applications for several disease/trauma states. He leads 4 different investigational new drug applications with patented stem cell technology. Additionally, he works on the clinical development of immune based therapies using natural killer cells. He had led a reference laboratory in testing various regenerative medicine products. Dr Gonzalez has been in the regenerative medicine field for more than 18 years and has several scientific publications. He has taught, spoken and led many conferences nationwide in the regenerative medicine sector. In this episode, Dr. Gonzalez reveals the inspiration behind his career in the stem cell space. We speak about why cell therapeutics is known as the wild west and the amount of FDA testing Dr. Gonzalez goes through to ensure safe products. Then, Dr. Gonzalez dives into what exactly stem cells are and how they can improve the natural processes that are already occurring in your body. Tune in as we talk about the importance of fasting, turning your life around after an autoimmune diagnosis, and who should consider getting cell therapeutics. Order Keto Flex: http://www.ketoflexbook.com -------------------------------------------------------- / / E P I S O D E S P ON S O R S Dr Phillips CBD Oil & Keto Fruit Chews. Visit www.drphillipscbd.com Good Idea Functional Sparkling Water Drinks. Visit http://www.goodidea.us and use the coupon code BEN at checkout. Text me the words "Podcast" +1 (786) 364-5002 to be added to my contacts list. [00:45] Why Dr. Gonzalez Started In The Stem Cell Space At college, Dr. Gonzalez studied embryonic stem cell research in spinal cord injuries. He loves to understand and study cells. Stem cells have properties that can heal the body. Plus, Dr. Gonzalez believes that stem cells can work against aging. In fact, stem cells are made naturally inside our body. [08:00] The Wild West of Cell Therapeutics & FDA Testing Any form of cell therapeutics is like the wild west. When you submit for the cells to have a Chemical Manufacturing Composition, it takes years. Gonzalez got his first clinical study approved in 2019 with the FDA. Essentially, the FDA boils down to the amount of testing. They are always ensuring that the product is safe. [13:05] How Stem Cells Can Improve The Natural Processes In Your Body Pompa and Dr. Gonzalez have been looking at using stem cells to control the inflammatory state and increase blood flow. We need increased blood flow because you'll notice brain fog and a loss of energy without it. The natural property of our body is actually to increase blood flow any way that it can. The cells in your body have three fates: Natural cell turnover Necrosis Senescence When our cells stop dividing, they start occupying space and cause havoc. These cells can cause wrinkles and gray hair. There's a cell type in our body that is a natural killer. These cells have three jobs: Remove a cancer cell Pick up viral load Wipe out senescence cells If you don't have immune health, you essentially have nothing. Every single disease has an immune component to it. [22:10] The Critical Role Fasting Plays In Longevity Aging is an issue of cell growth. If you consume food incorrectly, your body has to process all that. When you keep dividing cells, you are causing senescence. One proven lifestyle change for longevity is fasting. Also, diet is important because you force your body to remove the toxins in your body. [26:00] Transform Your Health With ReHealth's Cell Therapeutics Learn about ReHealth here: https://rehealth.com/ Register at the website, and they will contact you. The consultation is completely free. Depending on what you are looking to achieve will determine what type of therapeutics you should consider. Mesenchymal Stem Cell Therapy can help with the aging process. [30:30] How To Start Getting Your Life Back After An Autoimmune Diagnosis First and foremost, Dr. Gonzalez likes to discuss diet. If you are taking a bunch of meds, then you are not going to get better. Stem cells will give you a temporary effect unless you are doing all the key lifestyle components. Think about your goal. Gonzalez doesn't help people who are smoking. Stem cells will simply be a Band-Aid. Overall, stop smoking, start fasting, and fix your diet. [33:00] How Frequently You Should Consider Working With ReHealth's Cell Therapeutics How often you will need cell therapeutics will depend on your goals and your situation. Some people will have one session and feel great for the next five or six years. Most people will get therapeutics every six months or every year. The effect of stem cells initially is far greater than the sequential effects. [42:30] The Type of Person That Should Seriously Consider Cell Therapeutics If you have immune issues, you need cell therapeutics. Also, if you've tried everything else, then you should try cell therapeutics. Sadly, doctors will want to hand you a pill. If you are going to go see someone, find someone who knows integrative medicine. If you have any questions, Dr. Gonzalez wants to answer them! Email: Rgonzalez@TheBioBox.com AND MUCH MORE! Resources from this episode: Check out ReHealth: https://rehealth.com/ Email: Rgonzalez@TheBioBox.com Follow ReHealth Instagram: https://www.instagram.com/rehealth.stemcells/ Facebook: https://www.facebook.com/rehealth.stemcells Twitter: https://twitter.com/Rehealth_ Join theKeto Kamp Academy: https://ketokampacademy.com/7-day-trial-a WatchKeto Kamp on YouTube: https://www.youtube.com/channel/UCUh_MOM621MvpW_HLtfkLyQ Order Keto Flex: http://www.ketoflexbook.com -------------------------------------------------------- / / E P I S O D E S P ON S O R S Dr Phillips CBD Oil & Keto Fruit Chews. Visit www.drphillipscbd.com Good Idea Functional Sparkling Water Drinks. Visit http://www.goodidea.us and use the coupon code BEN at checkout. Text me the words "Podcast" +1 (786) 364-5002 to be added to my contacts list. *Some Links Are Affiliates* // F O L L O W ▸ instagram | @thebenazadi | http://bit.ly/2B1NXKW ▸ facebook | /thebenazadi | http://bit.ly/2BVvvW6 ▸ twitter | @thebenazadi http://bit.ly/2USE0so ▸clubhouse | @thebenazadi Disclaimer: This podcast is for information purposes only. Statements and views expressed on this podcast are not medical advice. This podcast including Ben Azadi disclaim responsibility from any possible adverse effects from the use of information contained herein. Opinions of guests are their own, and this podcast does not accept responsibility of statements made by guests. This podcast does not make any representations or warranties about guests qualifications or credibility. Individuals on this podcast may have a direct or non-direct interest in products or services referred to herein. If you think you have a medical problem, consult a licensed physician.
AUTOPHAGY! Yes, we are talking about this topic again! This week's episode covers some additional and amazing benefits of accessing autophagy through intermittent fasting, as much, and as often as possible, and why you will realize it's so much more powerful than you may realize! *I believe in you, even if you don't* >>If you need assistance or support on your journey, I am here, please reach out: TheFastingFocusedLifestyle.com
Can you live longer by changing the way you eat? There are many claims out there about intermittent fasting and its impact on health and longevity. Some people say you can extend your lifespan just by rearranging the time window of when you eat every day. Is that true, though? What does science say about fasting in humans and its effects on how long you'll live? Rather than examining this myself, I invited an intermittent fasting expert, Dr. Grant Tinsley, to explore the topic. Grant has been on the podcast before to discuss body fat measurement techniques, but as a scientist who's been involved in many time-restricted feeding studies on athletes, he's the perfect guest for this topic. Grant is an Associate Professor at Texas Tech University, the Director of the Energy Balance & Body Composition Laboratory, and is a Certified Strength and Conditioning Specialist (CSCS) and Certified Sports Nutritionist (CISSN). He has over 150 peer-reviewed journal articles and abstracts, with his major research interests being sports nutrition strategies, body composition assessment techniques, and intermittent fasting in active populations. Grant and I chat about . . . The role of mTOR, AMPK, and sirtuins in aging Metabolic age versus chronological age Rodent metabolism and why we can't apply research in animals to humans Autophagy, how long it takes to ramp up with fasting, and whether it matters Who should try fasting and who could potentially benefit Fasting's effects on muscle retention And more . . . So, if you're interested in the science of fasting's effects on longevity and how seriously you should take bold claims about lifespan and time-restricted feeding, check out this podcast and let me know your thoughts! --- Timestamps 0:00 - Try Whey+ risk-free today! Go to buylegion.com/whey and use coupon code MUSCLE to save 20% or get double reward points! 5:45 - Is intermittent fasting essential for overall health and longevity? 10:11 - What are some of the things that people are looking at in research and are being extrapolated into humans? 16:05 - What are your thoughts on the validity of metabolic aging? 22:36 - What are the benefits of fasting? 25:44 - What are some reasons I should consider fasting? 27:26 - What are your thoughts on fasting increasing longevity? 35:23 - How long do you have to fast for to make a meaningful health difference? 41:25 - Does fasting cause muscle loss? 49:03 - What are your thoughts on the importance of minimizing mTOR to maximize longevity? 1:01:30 - Where can people find you? --- Mentioned on the Show: Try Whey+ risk-free today! Go to buylegion.com/whey and use coupon code MUSCLE to save 20% or get double reward points! Grant's Instagram: https://www.instagram.com/grant_tinsley_phd Grant's Website: www.granttinsley.com
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.01.04.522687v1?rss=1 Authors: Huang, K.-C., Gomes, C., Shiga, Y., Belforte, N., VanderWall, K. B., Lavekar, S. S., Fligor, C. M., Harkin, J., Di Polo, A., Meyer, J. S. Abstract: Autophagy dysfunction has been associated with several neurodegenerative diseases including glaucoma, characterized by the degeneration of retinal ganglion cells (RGCs). However, the mechanisms by which autophagy dysfunction promotes RGC damage remain unclear. Here, we hypothesized that perturbation of the autophagy pathway results in increased autophagic demand, thereby downregulating signaling through mammalian target of rapamycin complex 1 (mTORC1), a negative regulator of autophagy, contributing to the degeneration of RGCs. We identified an impairment of autophagic-lysosomal degradation and decreased mTORC1 signaling via activation of the stress sensor adenosine monophosphate-activated protein kinase (AMPK), along with subsequent neurodegeneration in RGCs differentiated from human pluripotent stem cells (hPSCs) with a glaucoma-associated variant of Optineurin (OPTN-E50K). Similarly, the microbead occlusion model of glaucoma resulting in ocular hypertension also exhibited autophagy disruption and mTORC1 downregulation. Pharmacological inhibition of mTORC1 in hPSC-derived RGCs recapitulated disease-related neurodegenerative phenotypes in otherwise healthy RGCs, while the mTOR-independent induction of autophagy reduced protein accumulation and restored neurite outgrowth in diseased OPTN-E50K RGCs. Taken together, these results highlight an important balance between autophagy and mTORC1 signaling essential for RGC homeostasis, while disruption to these pathways contributes to neurodegenerative features in glaucoma, providing a potential therapeutic target to prevent neurodegeneration. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
This episode is brought to you by Pique, where plants and science intersect to produce teas and supplements of unrivaled efficacy, purity, and convenience. Pique teas are blended with other functional plants specifically designed to support metabolism, gut health, digestion, and shut down appetite…all while helping to ease bloat and curb sugar cravings. If you practice intermittent fasting, drinking these award-winning flavors will not break your fast! I enjoy Pique teas even when not fasting, so I use different flavors for different benefits throughout my day. Pique's revolutionary Tea Crystals—made with cold extraction technology—are organic, vegan, non-GMO, sugar-free, free of preservatives or additives, and triple toxin screened for purity. What's more, these pure teas dissolve in hot or cold water, so no prep or brewing is required. Try Pique today risk-free and get 5% off, plus a FREE pouch with 20 premium samples when you purchase a fasting bundle. Head over to piquelife.com/drjockers and use code DRJOCKERS. When it comes to gut health, bone broth is one of my go-to items I add to my diet. But, not all collagen is created equal. Many brands use poor-quality bones and heating methods that remove all of the potent benefits of collagen. And that is why I choose to use Paleovalley Bone Broth Protein Powder, you can get all the gut healing benefits without the mess from a company that uses only 100% grass-fed and finished cows and is not processed with high heat or extracted with harmful chemicals. There are no fillers, flow agents or added flavors. There is only ONE ingredient in this product and it's bovine bone broth protein. That's it. And you can get 15% off today using the code "jockers" or by clicking here: paleovalley.com/jockers Today's sponsor is Purality Health. Are hidden toxins and stressors making you feel run down and tired? Are you worried about oxidative stress from exposure to EMF, 5G, heavy metals, chemicals, and processed foods? Toxic is the new normal in our modern world. Toxins in our body take on the role of free radicals, causing oxidative damage on a cellular level that can lead to premature aging and a lower quality of life. One of the most powerful antioxidants known to man is glutathione. It fights free radicals while repairing DNA. However, not all glutathione supplements are created equal. If you're taking it in capsule or tablet form, you're missing out on key nutrients that will pass through your body without being absorbed. Purality Health has a patented formula that utilizes Micelle Liposomal technology which delivers the glutathione nutrients into your bloodstream, which has been proven to be 800% more efficient. Backed by a 180-day money-back guarantee, you can find them at puralityhealth.com and use the coupon code ‘DRJ' to get a 30% discount coupon. Dr. Jockers is in the hot seat in this episode of Functional Nutrition as he gets interviewed by Mike Collins as part of the ‘Quit Sugar Summit'. If you've enjoyed Dr. Jockers when he's interviewing other guests, or speaking on a particular health topic, then you're really in for a treat in this episode as he shares his story on how he came to be empowering people to reach their health potential. There's valuable information on fructose and corn syrup, and the first three things you can do to kick start your healthier eating regime. And because it's all told from the perspective of how Dr. Jockers achieved a healthy lifestyle himself, the conversation is super relatable. Knowledge is power, and with the knowledge that Dr. Jockers is freely dishing out, the power is truly in our hands to make those incremental changes that lead to us ditching the sugar and making more healthy eating decisions in general, setting us up for a lifetime of wellness that is well worth it. “I really focus on creating the world's best natural health content to inspire, educate, and empower as many people as possible to reach their health potential." -Dr. David Jockers Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean TuneIn Radio In This Episode: The Importance of the ‘Quit Sugar Summit' Sugar and David Jockers' childhood What happened when Dr. Jockers started drinking lots of water in college Discovering the term ‘intermittent fasting' What is the first thing you need to do to get healthy? What's in your salad dressing? What do we call it when our blood sugar is high? The dangers of high fructose corn syrup Should we limit our high-sugar fruit intake? Understanding ketones as a tool Our body's inflammation amplifying system Understanding the benefits of fasting What does autophagy actually mean? What are the hallmarks of all neurodegenerative diseases? What neuroplasticity has taught us The importance of having a thriving brain What does it mean to be ‘hangry'? Understanding Einstein's brain Increasing your own brain connectivity Understanding proprioception What is the future of health? Resources: Jockers – Pique – Use Code DRJOCKERS and get 5% off paleovalley.com/jockers – get 15% off today using the code "jockers" PUREDOSE® Micelle Liposomal Glutathione – Use Coupon Code DRJ for 30% off Quit Sugar Summit – The 10th Quit Sugar Summit | Jan 16th - Jan 22nd, 2023 Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https://www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/ ● If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/
In this podcast molecular Biologist Dr Elena Seranova joins us to talk through some of the exciting anti-aging and longevity compounds on the market currently, the research behind them and what they do in the body. We consider what you should think about when deciding to take a supplement what each compound does, it's mechanism of action what aging hallmarks each compounds combats. what senescent cells are and what senolytics do, the importance of methylation we cover Quercetin, Trimethylglycine, Nicotinamide Mononucleotide and Berberine Tune in to get the latest information on this exciting compounds and where the research is headed next. About Dr. Elena Dr. Elena Seranova is a scientist, serial entrepreneur, and business mentor. She has now founded multiple innovative biotechnological businesses. She first studied at the University of Ioannina with a major in Psychology. Dr. Elena then started a private practice before developing an interest in neuroscience. Dr. Elena continued her studies and earned her Master's Degree in Translational Neuroscience at the University of Sheffield. She now also holds a Doctorate Degree in Stem Cell Biology and Autophagy from the University of Birmingham. Dr. Elena's expertise in these fields led her to co-found the biotech start-up SkyLab Bio. She has written several peer-reviewed articles on autophagy. Her latest business is NMN Bio. Her own experiences with supplements have inspired her to expand the market to include cutting-edge anti-ageing supplements. NMN Bio reaches New Zealand, the UK, and Europe. Dr. Elena found her passion for drug discovery and autophagy. She has endeavoured to share this with the public through her research and work as an entrepreneur. To learn more about Dr. Elena and her work, visit NMN Bio. Health Optimisation Consulting with Lisa Are you struggling with a health issue and need someone who looks outside the square and someone connected to some of the greatest science and health minds in the world? Then reach out to us at email@example.com, we can jump on a call to see if we are a good fit for you or visit Lisa's Health Consulting If you have a big challenge ahead, are dealing with adversity or want to take your performance to the next level and want to learn how to increase your mental toughness, emotional resilience, foundational health, and more, contact us at firstname.lastname@example.org. Order Lisa's Books My latest book Relentless chronicles the inspiring journey about how my mother and I defied the odds after an aneurysm left my mum Isobel with massive brain damage at age 74. The medical professionals told me there was absolutely no hope of any quality of life again. Still, I used every mindset tool, years of research and incredible tenacity to prove them wrong and bring my mother back to full health within three years. Get your copy here: https://shop.lisatamati.com/collections/books/products/relentless. Lisa's Anti-Ageing and Longevity Supplements Lisa's full range of anti-aging, longevity and health optimisation supplements curated by Lisa herself working with some of the best supplement producers in the world. https://shop.lisatamati.com/ NMN: Nicotinamide Mononucleotide, an NAD+ precursor Feel Healthier and Younger* Researchers have found that Nicotinamide Adenine Dinucleotide or NAD+, a master regulator of metabolism and a molecule essential for the functionality of all human cells, decreases dramatically over time. What is NMN? NMN Bio offers a cutting edge Vitamin B3 derivative named NMN (beta Nicotinamide Mononucleotide) that can boost the levels of NAD+ in muscle tissue and liver. Take charge of your energy levels, focus, metabolism and overall health so you can live a happy, fulfilling life. Founded by scientists, NMN Bio offers supplements of the highest purity and rigorously tested by an independent, third-party lab. Start your cellular rejuvenation journey today. Support Your Healthy Ageing We offer powerful third-party tested NAD+ boosting supplements so you can start your healthy ageing journey today. Shop now: https://nmnbio.nz/collections/all NMN (beta Nicotinamide Mononucleotide) 250mg | 30 capsules NMN (beta Nicotinamide Mononucleotide) 500mg | 30 capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 250mg | 30 Capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 500mg | 30 Capsules Quality You Can Trust — NMN Our premium range of anti-ageing nutraceuticals (supplements that combine Mother Nature with cutting edge science) combats the effects of aging while designed to boost NAD+ levels. 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No caffeine, no sugar—just clean, on-demand energy for superior physical and cognitive performance. You can read about it here and https://shop.lisatamati.com/products/ketone-iq%E2%84%A2?_pos=2&_sid=727714231&_ss=r My ‘Fierce' Sports Jewellery Collection For my gorgeous and inspiring sports jewellery collection, 'Fierce', go to https://shop.lisatamati.com/collections/lisa-tamati-bespoke-jewellery-collection. Resources Gain exclusive access and bonuses to Pushing the Limits Podcast by becoming a patron! You can also connect with Matty on his Website YOUR DNA 360 REPORT + ONE-ON-ONE CONSULTATION Enjoyed This Podcast? If you did, subscribe and share it with your friends! Post a review and share it! If you enjoyed tuning in, then leave us a review. You can also share this with your family and friends so they can discover the benefits of an infrared sauna. Have any questions? You can contact me through email (email@example.com) or find me on Facebook, Twitter, Instagram and YouTube. 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A new research paper was published in Oncotarget's Volume 13 on December 17, 2022, entitled, “The role of pyrethroid derivatives in autophagy and apoptosis crosstalk signaling and potential risk for malignancies.” Pyrethroids are extensively used insecticides by virtue of insecticidal activity potential in Asia, especially India, and in different nations worldwide to counter mosquitoes and insects for household or agricultural needs. The continuous widespread and uncontrolled use of pyrethroids and its derivatives have influenced multiple deleterious effects resulting in a potential risk factor causing damage to organ systems. Allethrin and prallethrin are extensively used, yet their influences on human primary cells are very limited or under-reported. The potential mechanisms by which allethrin and prallethrin modulates human primary cells, especially the molecular mechanisms or interconnectivity of autophagy-apoptosis, their clinical relevance in human subjects or patients are not well defined. In the current study, researchers Jyothi Puvula, Narendra Maddu, Nagajothi Gutam, Asha Parimal, and Raghavendra B. Pongali from Sri Krishnadevaraya University, Queen Mary's College, Manipal University, and National Institute of Biomedical Genomics furnished the evidence that both allethrin and prallethrin user samples significantly induced Ccl2 mRNA expression, increased amount of reactive oxygen intermediate, inhibited membrane bound enzymes and altered membrane fluidity. Pyrethroid derivative users had induced levels of lipid peroxidation and induced binding activities of transcription factors(tfs) like CEBP-β and NF-AT. Pyrethroid derivatives induced autophagy, elicited intracellular Ca2+ concentration, calcineurin and regulated proapoptotic genes, DAPK1, Bim. “Our current study presumably comprises the initial investigation of a very new mechanism of pyrethroid derivatives-moderated programmed cell death in various cell sets or types, like human primary cells where-in this is a late event, is documented.” Hence, the current research study might be significant in the various pyrethroid derivatives-allied hematological-related cancers and immunosuppressant or auto-immune disorders. In the foremost instance, the researchers present data stating that pyrethroid derivatives induces multiple cell signaling cascades, like CEBP-β, NF-AT, ERK and MAPK having a role in autophagy thereby; synchronously effectively impact on the apoptosis, therefore causing hematological tumors and toxic or immune related disorders. “Overall this current study might facilitate to formulate therapeutics or intervention targets that might serve to decrease the effect or impact of pyrethroids derivatives by targeting the signaling cascade that serves to minimize the modulation of autophagy mediated apoptosis.” DOI: https://doi.org/10.18632/oncotarget.28328 Correspondence to: Raghavendra B. Pongali - firstname.lastname@example.org Keywords: allethrin, prallethrin, autophagy, apoptosis, Ccl2 About Oncotarget: Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. To learn more about Oncotarget, visit Oncotarget.com and connect with us on social media: Twitter - https://twitter.com/Oncotarget Facebook - https://www.facebook.com/Oncotarget YouTube – www.youtube.com/c/OncotargetYouTube Instagram - https://www.instagram.com/oncotargetjrnl/ LinkedIn - https://www.linkedin.com/company/oncotarget/ Pinterest - https://www.pinterest.com/oncotarget/ LabTube - https://www.labtube.tv/channel/MTY5OA SoundCloud - https://soundcloud.com/oncotarget For media inquiries, please contact: email@example.com.
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.12.31.522394v1?rss=1 Authors: Zhang, T., Bae, H.-G., Bhambri, A., Zhang, Y., Barbosa, D., Xue, J., Wazir, S., Mulinyawe, S. B., Kim, J. H., Sun, L. O. Abstract: Oligodendrocytes are the sole myelin producing cells in the central nervous system. Oligodendrocyte numbers are tightly controlled across diverse brain regions to match local axon type and number, but the underlying mechanisms and functional significance remain unclear. Here, we show that autophagy, an evolutionarily conserved cellular process that promotes cell survival under canonical settings, elicits premyelinating oligodendrocyte apoptosis during development and regulates critical aspects of nerve pulse propagation. Autophagy flux is increased in premyelinating oligodendrocytes, and its genetic blockage causes ectopic oligodendrocyte survival throughout the entire brain. Autophagy acts in the TFEB-Bax/Bak pathway and elevates PUMA mRNA levels to trigger premyelinating oligodendrocyte apoptosis cell-autonomously. Autophagy continuously functions in the myelinating oligodendrocytes to limit myelin sheath numbers and fine-tune nerve pulse propagation. Our results provide in vivo evidence showing that autophagy promotes apoptosis in mammalian cells under physiological conditions and reveal key intrinsic mechanisms governing oligodendrocyte number. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Watch the full video interview on YouTube here: https://bit.ly/512drmindypelz Dr. Mindy Pelz (IG: @dr.mindypelz) is a renowned holistic health expert and one of the leading voices in educating women about their bodies. She is on a mission to start a women's health revolution! Today we're discussing Mindy's new book Fast Like a Girl: A Woman's Guide to Using the Healing Power of Fasting to Burn Fat, Boost Energy, and Balance. In this episode, we discuss: The benefits of intermittent fasting How many hours of fasting gets you to the superhuman state? The 6 different types of fasting based on time Autophagy triggers after 17 hours of fasting Simple tips to stimulate autophagy Supplements that supercharge autophagy What happens to cells after they die from fasting? Top hacks for opening up your detox pathways What is a fasting snack? Test your blood sugar to find out if coffee breaks your fast Mindy's daily fasting routine Why Mindy times her dinner to sunset Learn how to break a short fast vs. a longer fast How fasting helped Mindy manage perimenopause Fasting stimulates BDNF The importance of tracking your cycle The 30-day reset Get to know the characteristics of estrogen and progesterone How fasting helped heal Mindy's Achilles tendon injury Fasting changes your microbiome Treat SIBO with a 24-hour fasting period Reboot the dopamine system with a 48-hour fast Mindy's thoughts on calorie restriction for longevity Know why you're fasting The top 3 tips to lose weight How glycation impacts aging What is metabolic switching? The 5-1-1 fasting variation Fasting is not a one size fits all tool Menopausal women should try fasting with the moon cycle Men benefit from taking fasting breaks Show sponsor: Organifi
“Pay attention to your gut biome. That's a little internal pharmacy that we have. And if you are good to the mitochondria and your gut biome, they will be good back to you.” –Leslie Kenny Leslie Kenny is an autoimmune survivor/thriver, certified health coach and Founder and CEO of Oxford Healthspan, bringing to consumers the latest scientifically based molecules proven to slow aging. She is also the Co-Founder of the non-profit Oxford Longevity Project which aims to bring the latest scientific breakthroughs on healthy aging to the general public. Leslie holds degrees from Berkeley and Harvard. In this episode we discuss the benefits of spermidine for our bones and overall health. Links* https://oxford-healthspan.myshopify.com/?sca_ref=3028979.JVcKMC9tDn Use code HAPPYBONES for 10% savings. Timestamps [01:37] Leslie Kenny's Backstory [14:33] Spermidine and the Mechanism of Action [18:57] What is Autophagy [23:09] Spermidine and the Bones [36:32] How to Get That One Milligram [49:09] Leslie's Spermidine Recommendations DISCLAIMER – The information presented on this podcast should not be construed as medical advice. It is not intended to replace consultation with your physician or healthcare provider. The ideas shared on this podcast are the expressed opinions of the guests and do not always reflect those of Margie Bissinger and Happy Bones, Happy Life Podcast. *In compliance with the FTC guidelines, please assume the following about links on this site: Some of the links going to products are affiliate links of which I receive a small commission from sales of certain items, but the price is the same for you (sometimes, I even get to share a unique discount with you). If I post an affiliate link to a product, it is something that I personally use, support and would recommend. I personally vet each and every product. My first priority is providing valuable information and resources to help you create positive changes in your health and bring more happiness into your life. I will only ever link to products or resources (affiliate or otherwise) that fit within this purpose.
Check out the incredible antiviral effects of autophagy! Dr. Berg's Keto and IF Lab: https://www.facebook.com/groups/drbergslab/ How to Bulletproof your Immune System FREE Course: https://bit.ly/39Ry3s2 FREE MINI-COURSE ➜ ➜ Take Dr. Berg's Free Keto Mini-Course! ADD YOUR SUCCESS STORY HERE: https://bit.ly/3z9TviS Find Your Body Type: https://www.drberg.com/body-type-quiz Talk to a Product Advisor to find the best product for you! Call 1-540-299-1557 with your questions about Dr. Berg's products. Product Advisors are available Monday through Friday 8 am - 6 pm and Saturday 9 am - 5 pm EST. At this time, we no longer offer Keto Consulting and our Product Advisors will only be advising on which product is best for you and advise on how to take them. Dr. Eric Berg DC Bio: Dr. Berg, 51 years of age is a chiropractor who specializes in weight loss through nutritional & natural methods. His private practice is located in Alexandria, Virginia. His clients include senior officials in the U.S. government & the Justice Department, ambassadors, medical doctors, high-level executives of prominent corporations, scientists, engineers, professors, and other clients from all walks of life. He is the author of The 7 Principles of Fat Burning. Dr. Berg's Website: http://bit.ly/37AV0fk Dr. Berg's Recipe Ideas: http://bit.ly/37FF6QR Dr. Berg's Reviews: http://bit.ly/3hkIvbb Dr. Berg's Shop: http://bit.ly/3mJcLxg Dr. Berg's Bio: http://bit.ly/3as2cfE Dr. Berg's Health Coach Training: http://bit.ly/3as2p2q Facebook: https://www.facebook.com/drericberg Messenger: https://www.messenger.com/t/drericberg Instagram: https://www.instagram.com/drericberg/ YouTube: http://bit.ly/37DXt8C Pinterest: https://www.pinterest.com/drericberg/
In this episode, Dr. Will Cole is joined by the chief medical officer of Timeline Nutrition, Dr. Anurag Singh. You may have learned about cellular health in science class, but this episode covers everything you didn't learn (but should have!) in school. From the best hacks to improve your mitochondria to harnessing the superhero postbiotics, Urolithin A, we cover exactly what you need to know to optimize your overall health and support anti-aging. For all links mentioned in episode: www.drwillcole.com/podcast Please note that this episode may contain paid endorsements and advertisements for products and services. Individuals on the show may have a direct or indirect financial interest in products or services referred to in this episode. Thank you to Timeline Nutrition for sponsoring this episode. Timeline is offering 10% off your first order of Mitopure. Go to timelinenutrition.com/willcole and use code WILLCOLE to get 10% off your order Produced by Dear Media.
We think of stress as “bad” for you, but what if some forms of stress could actually help us grow and change for the better? On today's episode Forrest and Dr. Rick are joined by Dr. Elissa Epel, a psychologist and leading stress researcher, to explore the science behind the stress response. They talk about the different forms of stress, what separates “good” stress from “bad” stress, how we can take advantage of good stress, and dealing with existential forms of stress like the climate crisis. About our Guest: Elissa Epel is a psychologist, bestselling author, and a Professor and Vice Chair in the Department of Psychiatry at the University of California, San Francisco. Her research focuses on stress, well-being, and optimal aging. She's also the best-selling co-author of The Telomere Effect, and her newest book is The Stress Prescription: Seven Days to More Joy and Ease.New Course From Rick! Learn the lessons of a lifetime in the new and improved Foundations of Wellbeing 2.0 program. This yearlong, online program teaches you how to grow the 12 key inner strengths that lead to lasting wellbeing during difficult times. It's currently 40% off, and you can use the code BeingWell25 to get an additional 25% off the purchase price.Watch the Episode: Prefer watching video? You can watch this episode on YouTube.Key Topics:0:00: Introduction1:10: Toxic stress vs. hormetic stress6:30: Challenge orientation vs. threat response11:35: Simple anchoring practices and their effects17:00: Autophagy19:00: Practical consequences of different forms of stress25:25: Distinguishing physiological from psychological stress31:00: Comfort with uncertainty and shared existential concerns40:20: The future of the planet and its inequities42:40: RecapSponsors:Join over a million people using BetterHelp, the world's largest online counseling platform. Visit betterhelp.com/beingwell for 10% off your first month!Want to sleep better? Try the Calm app! Visit calm.com/beingwell for 40% off a premium subscription.Connect with the show:Subscribe on iTunesFollow Forrest on YouTubeFollow us on InstagramFollow Forrest on InstagramFollow Rick on FacebookFollow Forrest on FacebookVisit Forrest's website
Meet Cormack Jackson, he's the Chief Of Staff to Shazam Cofounder Dhiraj Mukherjee & Independent Consultant in the UK.What did we talk about:1. Networking or coffee date2. The World Cup3. Business Hack! Walking with coffee and creating chapters (mental mind stamps) with landmarks. Big Ben and the economy. Canary Wharf and the recession.4. TikTok coffee date, viral IG post and Dating Intelligence5. Influence and Building your Superpower6. Losing $35 million gambling in Vegas and influence7. White chocolate is not chocolate8. What kind of coffee does Santa drink? Espresso and Bezos stepping down because he cannot keep up with Santa.9. Showing up late to the coffee date10. Chatting in queue, securing two more dates and the one you're in the line with.11. Ambushing your future boss with an interview on a podcast.12. London School of Economics and a Sociology degree.13. Recording team Zooms for content for trailers for social media on Linkedin. capturing the essence of his boss' ideas and thoughts. Ambushing your boss or guest!14. Nicaragua celebrity and #1 business podcast or number #1 in Business on Apple15. Coffee from Nicaragua16. Is Santa real? Tooth Fairy?17. Hand extensions for T-Rex for Christmas. Jurassic Park episode 3 with David Attleboro.18. Apache of Marketing on Linkedin.Buy Me a CoffeeHolly Shannon's WebsiteZero To Podcast on AmazonHolly Shannon's new Youtube Channel, Subscribe here!Interview with Johnny Giangregorio on YTHolly Shannon, InstagramHolly Shannon, LinkedinHolly Shannon, TwitterCormack Jackson on Linkedin#Coffee #barista #pumpkinspicedlatte #Starbucks #DunkinDonuts #blackcoffee #darkroast #lightroast #latte #macchiato #cappuccino #espresso#centralperk #Bulletproof #howtomakecoffee #coffeebeans #coffeedate #virtualcoffee #coffeebreak #coldbrew #coffeemachine #coffeegrinder #connection #community #frenchpress #coffeehousemusic #cafe #arabica #espresso #cuppajoe #decaffeinated #caffeine #coffeeaddiction #cappuccino
Today, I am blessed to have for a THIRD time, Dr. Don Clum. He graduated from Life University in Marietta, GA in 1997 with a degree in Human Nutrition. He then moved to Life Chiropractic College West in California, where he graduated with his Doctorate of Chiropractic in 2000. This originally aired in July 2021. After graduation, Dr. Clum moved to San Jose, Costa Rica where he was invited to work with the Costa Rican Olympic Committee and Athletes. Dr. Clum participated in the National, Central American and Caribbean and Central American Games as the team chiropractor and as the official chiropractor for two professional soccer teams. As a frequent guest on National Television and Radio, Dr. Clum was influential in bringing the gift of holistic health care to the people of Central America and worked with the government programs, instituting W.H.O. procedures and working directly with the indigenous populations of Costa Rica. He was sought after as a speaker and has presented to various professional sports teams, universities, medical groups, medical and chiropractic schools, businesses and government agencies. Dr. Clum was instrumental in forming the first Colegio or “Board” and enacting the first legislation recognizing chiropractic as a licensed and legal healing profession in Costa Rica. In this episode, Dr. Clum opens the show by revealing why the 'calories in, calories out' method of eating is bogus. Plus, he tells us how glycogen works and the reason that too many people oversimplify it. Dr. Clum explains why people who burn more calories are happier, and he gives an overview of the blood markers you should use to measure insulin health. Tune in as we chat about the problem with snacking, how to know if you're fasting too much, and we dig deep into adrenals, insulin, and cortisol. Order Keto Flex: http://www.ketoflexbook.com -------------------------------------------------------- / / E P I S O D E S P ON S O R S PureForm Omega Plant Based Oils (Best Alternative to Fish Oil): http://www.purelifescience.com Use ben4 for $4.00 off. BiOptimizers Kapex Special Offer: www.kenergize.com/ketokamp Use the code ketokamp10 for 10% off Text me +1 (786) 364-5002 [02:45] Does ‘Calories in vs. Calories out' Really Matter? Humans are dynamic open systems. First of all, the accuracy for calories is fundamentally off. There's automatically up to a 25% error rate for calories. Plus, our body will process calories differently depending on what they are. Sugars will be released into your body differently depending on your gut bacteria. [07:30] The Glycogen Concept Is Flawed – We Oversimplify It We never tap out our glycogen. You don't have to reduce glycogen by a significant amount if you're metabolically flexible. The glycogen in our liver is there for our body. Glycogen appears to be pretty steady no matter what you do. You don't have to deplete all your glycogen to go into fat burning. [17:30] People Who Burn More Calories Are Happier People who burn more calories are happier because of different hormonal states. Your body will interpret nutrients in your gut. Food is not fuel – it's information. Your body doesn't handle processed food very well, even protein powders. [24:10] Blood Markers You Can Use To Monitor Insulin Health You can do serum insulin, which is fasting insulin. You want that number as low as possible. This number should be around 2 or 3. When you eat, that number can blow up to seven times. If you start at 20, then you'll go up to 140. If you keep doing that each day, then you have a problem. Most Americans eat in a fifteen-hour window – they are eating from the time they wake up to the time they go to bed. [26:05] Why Snacking Could Be Damaging Your Health Snacking causes a lot of issues. People are snacking between 19 and 23 times a day. If you are constantly digesting, then you aren't recycling. When your body is resting, then it is in autophagy. So, your cells will start to work better. Autophagy allows new cells to come in and replace cells that have died. [31:40] Signs You Could Be Fasting Too Often Clum teaches progressive fasting rotations. Growth will start to kick in after a fast. You could lose 97% of your new cells if you don't end a fast in the right way. It is rare that you lose lean body muscle from fasting. You have to have a body fat percentage of 5% or less to tap into muscle during a fast. [34:10] Does It Matter What Foods You Break A Fast With? What breaks the fast depends on why you're doing the fast. The food you eat will matter up to two weeks after you fast. Eat foods that are insulin friendly. Plus, exercise is a key component of repairing your cells. [50:45] Quitting Junk Food Causes Withdrawals Like Drug Addiction When an addict stops drinking, they will be lightheaded, irritable, feel terrible, shake, and sweat. When some people skip a meal, they feel the exact same way. Food fuels the addiction pathway. In fact, food is more addictive than drugs. Food hits dopamine and serotonin. Every time insulin gets shot out, so does serotonin. [55:30] Dr. Clum Does Not Encourage C-Peptide Level Testing If triglycerides are over 100, there's an insulin issue. Over 150 is a metabolic syndrome marker. Insulin resistance is inversely related to vitamin D. If your vitamin D is low, you have insulin resistance. Insulin will hold down vitamin D. [60:10] The Relationship Between Adrenals, Insulin, and Cortisol We beat up the adrenals a lot as the culprit for fatigue and adrenal fatigue. However, only a third of the cortisol is actually made in the adrenal. The brain makes a third of the cortisol because it is highly sensitive to inflammation. It makes cortisol to keep inflammation levels as low as possible. When you burn fat, it's an inflammatory process. We will recycle about 1.3% of our cells a day. What matters is how efficient you are in the process. [73:45] An Overweight Diabetic Only Has To Lose One Gram For an overweight type two data to become a normal person, how much weight do they have to lose? People think it's 10% of their body weight. However, the answer is one gram. The gram has to come out of the pancreas. If a 350 lb. person loses one gram from the pancreas, they will no longer be a diabetic. AND MUCH MORE! Resources from this episode: Insulin Friendly Fasting Secrets: https://www.facebook.com/groups/insulinfriendly Your Wellness Tribe: https://yourwellnesstribe.com/about-dana-don/ Follow Dr. Clum LinkedIn: https://www.linkedin.com/in/dr-don-clum-12069970/ Facebook: https://www.facebook.com/don.clum.10 Canva Fasting Schedule: https://www.canva.com/design/DAEkLovNVfM/H5rQBDQ4bfvsXWLpXORDiQ/edit Don Clum | Vitamin D & The Immune System | How Diabetes Weakens The Immune System: https://www.youtube.com/watch?v=RRjcH_ptGkk 30 Days Fasting, Insulin & Weight Gain, Reversing Diabetes, Vitamin D & Insulin Connection – Dr. Don Clum KKP 009: https://bit.ly/3wCulrR Join theKeto Kamp Academy: https://ketokampacademy.com/7-day-trial-a WatchKeto Kamp on YouTube: https://www.youtube.com/channel/UCUh_MOM621MvpW_HLtfkLyQ Order Keto Flex: http://www.ketoflexbook.com -------------------------------------------------------- / / E P I S O D E S P ON S O R S PureForm Omega Plant Based Oils (Best Alternative to Fish Oil): http://www.purelifescience.com Use ben4 for $4.00 off. BiOptimizers Kapex Special Offer: www.kenergize.com/ketokamp Use the code ketokamp10 for 10% off Text me +1 (786) 364-5002 *Some Links Are Affiliates* // F O L L O W ▸ instagram | @thebenazadi | http://bit.ly/2B1NXKW ▸ facebook | /thebenazadi | http://bit.ly/2BVvvW6 ▸ twitter | @thebenazadi http://bit.ly/2USE0so ▸clubhouse | @thebenazadi Disclaimer: This podcast is for information purposes only. Statements and views expressed on this podcast are not medical advice. This podcast including Ben Azadi disclaim responsibility from any possible adverse effects from the use of information contained herein. Opinions of guests are their own, and this podcast does not accept responsibility of statements made by guests. This podcast does not make any representations or warranties about guests qualifications or credibility. Individuals on this podcast may have a direct or non-direct interest in products or services referred to herein. If you think you have a medical problem, consult a licensed physician.
Intermittent fasting isn't the only way to enhance autophagy. Here's how coffee and herbs can help. Dr. Berg's Keto and IF Lab: https://www.facebook.com/groups/drbergslab/ How to Bulletproof your Immune System FREE Course: https://bit.ly/39Ry3s2 FREE MINI-COURSE ➜ ➜ Take Dr. Berg's Free Keto Mini-Course! ADD YOUR SUCCESS STORY HERE: https://bit.ly/3z9TviS Find Your Body Type: https://www.drberg.com/body-type-quiz Talk to a Product Advisor to find the best product for you! Call 1-540-299-1557 with your questions about Dr. Berg's products. Product Advisors are available Monday through Friday 8 am - 6 pm and Saturday 9 am - 5 pm EST. At this time, we no longer offer Keto Consulting and our Product Advisors will only be advising on which product is best for you and advise on how to take them. Dr. Eric Berg DC Bio: Dr. Berg, 51 years of age is a chiropractor who specializes in weight loss through nutritional & natural methods. His private practice is located in Alexandria, Virginia. His clients include senior officials in the U.S. government & the Justice Department, ambassadors, medical doctors, high-level executives of prominent corporations, scientists, engineers, professors, and other clients from all walks of life. He is the author of The 7 Principles of Fat Burning. Dr. Berg's Website: http://bit.ly/37AV0fk Dr. Berg's Recipe Ideas: http://bit.ly/37FF6QR Dr. Berg's Reviews: http://bit.ly/3hkIvbb Dr. Berg's Shop: http://bit.ly/3mJcLxg Dr. Berg's Bio: http://bit.ly/3as2cfE Dr. Berg's Health Coach Training: http://bit.ly/3as2p2q Facebook: https://www.facebook.com/drericberg Messenger: https://www.messenger.com/t/drericberg Instagram: https://www.instagram.com/drericberg/ YouTube: http://bit.ly/37DXt8C Pinterest: https://www.pinterest.com/drericberg/
Welcome to day 11 of 12 Days of Biohacking Gifts! Each day I interview a different health and wellness brand, host a giveaway for their products on my Instagram account, and share valuable information with you on how they're shaping the biohacking world. I chat with Don Moxley from spermidineLIFE. We talk about what autophagy is, how spermidine helps with autophagy, the four pillars of health to achieve longevity, and many more. With age, the level of spermidine in your body decreases, causing cells to become sluggish. With SpermidineLIFE you can counteract this decrease in spermidine levels! Spermidine activates cell renewal and ensures the maintenance of your cell health. Join the giveaway by going to my Instagram account - @biohackingbrittany. We talk about: 02:00 - Spermidine and autophagy 03:20 - Autophagy and why it's important 05:00 - We live in aquariums and how it impacts us 07:00 - The correlation between spermidine and autophagy 08:20 - How to increase autophagy in your body 09:00 - The four pillars of good health 12:00 - What should your purpose be to be healthier 13:15 - Steven Kotler's: The Art Of Impossible 14:15 - Stephen Covey's: The 7 Habits Of Highly Effective People 15:15 - How Don defines longevity 19:00 - Benefits of taking spermidine Resources: Visit spermidineLIFE and enter code BIOHACKINGBRITTANY to get a discount on all of their products. Let's connect: Instagram Facebook TikTok Subscribe to my newsletter Shop my favorite health products Listen on Spotify, Apple Podcasts, Google Podcasts
Follow Johnny on InstagramPurchase a Lifey Planner: (buy 4 for one year's worth of goals!)https://www.lifeyplanners.com/products/lifey-plannersFollow Lifey Planners on InstagramOur episode on YoutubeBuy Me a CoffeeHolly Shannon's WebsiteZero To Podcast on AmazonHolly Shannon's new Youtube Channel, Subscribe here!Holly Shannon, InstagramHolly Shannon, LinkedinHolly Shannon, TwitterPhoto of Megan Smith on Mount KilamanjaroAtomic Habits Audiobook by James ClearAtomic Habits Hardcover by James ClearAtomic Habits Paperback by James Clear #Coffee #barista #pumpkinspicedlatte #Starbucks #DunkinDonuts #blackcoffee #darkroast #lightroast #latte #macchiato #cappuccino #espresso#centralperk #Bulletproof #howtomakecoffee #coffeebeans #coffeedate #virtualcoffee #coffeebreak #coldbrew #coffeemachine #coffeegrinder #connection #community #frenchpress #coffeehousemusic #cafe #arabica #espresso #cuppajoe #decaffeinated #caffeine #coffeeaddiction #cappuccino
Mike Crowson is the owner of Fit Legacy Marketing Agency and Coffee Over Cardio®. Mike has created a powerhouse e-commerce coffee company where we has now 2 major licensing deals with Dippin' Dots® and FRUITY PEBBLES®. An Alabama native, he decided to move to New York City to chase his dreams of becoming an entrepreneur when he was 22. From taking the leap in his at the time Fitness career to New York > LA > Dallas, a decade later has the stories to tell how he came from jobless to building a recognizable social media brand and how he continues helps others do the same!Mike Crowson on InstagramCoffee over Cardio on InstagramBuild Your LegacyOur episode on YoutubeBuy Me a CoffeeHolly Shannon's WebsiteZero To Podcast on AmazonHolly Shannon's new Youtube Channel, Subscribe here!Holly Shannon, InstagramHolly Shannon, LinkedinHolly Shannon, TwitterCleveland Clinic and Low Acidity of Coffee #Coffee #barista #pumpkinspicedlatte #Starbucks #DunkinDonuts #blackcoffee #darkroast #lightroast #latte #macchiato #cappuccino #espresso#centralperk #Bulletproof #howtomakecoffee #coffeebeans #coffeedate #virtualcoffee #coffeebreak #coldbrew #coffeemachine #coffeegrinder #connection #community #frenchpress #coffeehousemusic #cafe #arabica #espresso #cuppajoe #decaffeinated #caffeine #coffeeaddiction #cappuccino