Podcasts about Autophagy

In this episode of the Pain and Performance Podcast, Dr. Derrick Hines breaks down senescent cells, often called “zombie cells,” and why researchers are increasingly interested in their role in aging, inflammation, and age-related disease.Derrick explains what happens when cells become senescent and explores several areas being studied for cellular health, including exercise, fasting and autophagy, nutrition, and emerging senolytic compounds. He also discusses why reducing the accumulation and effects of dysfunctional cells has become an important area of longevity research.In This Episode-- What “zombie cells” are and why they accumulate-- How cellular senescence relates to aging and inflammation-- Autophagy and the body's cellular recycling processes-- What we're learning about fasting and cellular health-- How exercise may influence markers of cellular senescence-- Emerging research into senolytics, quercetin, fisetin, and dasatinib-- Why cellular senescence is becoming a major area of longevity research#CellularHealth #HealthyAging #Longevity #SenescentCells #AutophagyInstagram:https://www.instagram.com/derrickbhines/Youtube:https://www.youtube.com/@DrDerrick

Sleep, Growth Hormone, and Autophagy: How Rest, Diet, and Fasting Support Metabolic Health and Longevity: Nutritionist Leyla Muedin discusses how deep, early non-REM sleep boosts growth hormone for muscle, bone, fat burning, and metabolic health, and reviews a Cell study in which UC Berkeley researchers mapped hypothalamic circuits and feedback through the locus coeruleus showing a tight balance between sleep, growth hormone release, and wakefulness, with implications for metabolic disease and neurodegeneration. She connects poor sleep to higher blood sugar, insulin, and cortisol, which can suppress growth hormone, and advises avoiding sweet post-workout foods (e.g., smoothies, bananas, fruit yogurt) that stimulate insulin and blunt growth hormone, recommending protein and fat instead. She then explains autophagy and mitophagy as cellular cleanup processes linked to longevity, noting autophagy peaks after 12 hours of fasting, highlighting roles in mitochondrial quality control, immunity, and neurodegenerative disease, and mentions interventions such as fasting, exercise, ketogenic diets, and investigational inducers like rapamycin and urolithin A.

Dr. Will Cole goes solo to dig into the science behind cellular confusion, why your cells forget what they're created to do, and what to do about it. In this deep dive, he breaks down the "Inflammatory Core Four" (sugar, seed oils, grains, and dairy), the concept of xenohormesis, and how fasting and food timing activate autophagy, mitophagy, and your body's own cellular repair pathways. For all links mentioned in this episode, visit http://www.drwillcole.com/podcastPlease note that this episode may contain paid endorsements and advertisements for products and services. Individuals on the show may have a direct or indirect financial interest in products or services referred to in this episode.SPONSORS:Go to HANSforDogs.com/WELL and make sure to use the code WELL get $30 off your first month. Plus, every order is backed by a 90-day money-back guarantee, so you can try HANS completely risk-free. HANS™. Tested on humans, perfected for dogs.Visit DRINKAG1.com/willcole and get an AG1 Pro YETI Shaker in your AG1 Pro Welcome Kit. EllaOla is offering my listeners 20% off your first purchase. Just go to EllaOla.com/WILLCOLE, discount applied automatically; No code needed.Head to MANUKORA.com/WILLCOLE and use code WILLCOLE to save up to 31% plus $75 worth of free gifts with the Starter Kit, which comes with an MGO 850+ Manuka Honey jar, 5 honey travel sticks, a wooden spoon, a guidebook, and an onboarding call with Manukora's clinical nutritionist.You can get an additional 15% off their 90-day subscription Starter Kit by going to fatty15.com/WILLCOLE and using code WILLCOLE at checkout.Text ABW to 64000 to get twenty percent off all IQBAR products, plus FREE shipping. Message and data rates may apply.Produced by Dear Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This podcast is made possible by our listeners and viewers. If this show has brought you value, you can support it by becoming a member of The Way Forward, our platform designed to help you find the health and freedom community (people, practitioners, schools, farms, and more) near you. Your membership directly supports the podcast and the work we do.Want to get started with dry fasting but aren't sure how? Click HERE to access a FREE PDF guide to dry fasting, and a 47-minute masterclass with Theo and Sean.Most people call water fasting a fast. My guests argue it isn't, and I haven't looked at cleansing the same since.Theo Lucier founded Forgotten Health after burning out in commercial real estate and rebuilding his biology from the cellular level up. Sean McCormick coaches high-intensity professionals and co-founded Dry Fast With Friends with him.Their claim: the moment you drink water, your GI tract turns on, gluconeogenesis kicks in, and your body starts breaking down muscle and organ tissue for glucose. Dry fasting shuts that pathway off entirely. What happens next gets strange.Black bile purging. Parasites exiting through unexpected places. TRT users regrowing testicular size in five days. Chipped teeth filling in. A 60-year-old woman saying her body felt 19 again. Plus how sleep is technically a dry fast, and why the recovery protocol matters more than the fast itself.I came in a committed water faster. I'm leaving with a seven-day dry fast booked.You'll Learn:[0:00] Introduction[9:32] A water fast is just a water diet, and fasting as a portal through life transitions [25:20] The glymphatic system, and how sleep is a dry fast[30:38] The body makes its own perfect metabolic water[38:06] Why dry fasting could be the future of health optimization[47:22] Prahlad Jani claimed no food or water for decades[1:09:09] Sean's meditation crescendo and Theo's white light download [1:25:11] Why dry fasting alone is a dangerous idea[1:37:31] A black bile purge and prioritized liver healing[1:48:17] TRT testicle recovery and a chipped tooth filling in[2:11:41] An Estonian man's ecstatic connection to Gaia, and the start of refeeding[2:31:28] Animal protein for recovery, and prayer when the veil is thinRelated The Way Forward Episodes:The 4th Phase of Water: The Blueprint for Biological Energy with Dr. Gerald Pollack | PodcastFasting for Vibrant Health with Loren Lockman | PodcastComedy, Cleansing & Fasting with Liquid Gold featuring Mike Cardamone | PodcastResources Mentioned:Healing is Voltage by Jerry L. Tennant | BookFast Like a Girl by Dr. Mindy Pelz | Book20 Questions & Answers About Dry Fasting by Sergey Filonov | BookFood Lies Documentary by Brian Sanders | WebsiteThe Phoenix Protocol: Dry Fasting for Rapid Healing and Radical Life Extension by August Dunning | BookFind more from Theo and Sean:Dry Fast With Friends | WebsiteTheo Lucier, Forgotten Health | Website | PDry Fast With FriendsroductsSean McCormick | Website | InstagramDonate to The Way Forward here.The Way Forward is Sponsored By:Get 10% off your Heart & Soil order with code THEWAYFWRD at checkout. Shop Heart & Soil here.Eating well shouldn't be complicated. Dr. Cowan's Garden makes it simple to increase your daily nutrient density with their signature vegetable powders, clean pantry staples, and pasture-raised products. Family-run and committed to "beyond-organic" quality.* Offer: Use code THEWAYFORWARD for 15% off your first order.* Shop: Dr. Cowan's GardenWant to grow your podcast but not sure what's actually working? Podigy helps me produce The Way Forward. Take their free assessment to get clear on your next move—and a chance to win a call with their founder.

In this episode, Dr. David Jockers walks you through a complete 14-day progressive fasting protocol built specifically to burn visceral fat, the inflammatory fat that wraps around your liver, pancreas, heart, and intestines, applying pressure to those organs and choking off circulation.   You will get the exact day-by-day schedule: a 14/10 fast for days one through three, a 16/8 upgrade for days four through six, an 18/6 window for days seven through thirteen to activate autophagy, and a single 24-hour water fast on day fourteen that triggers a growth hormone surge of up to 2,000 percent in men and 1,300 percent in women.   Dr. Jockers also covers the three eating rules that make or break the protocol, how to supercharge your fast with hydration, coffee, and light movement, the protein and fat first rule for breaking a fast correctly, and his answers to the eight questions he gets asked most often, from sweeteners and dizziness to whether the fat comes right back. In This Episode:  00:00 Hunger Before Fast Ends 00:18 Podcast Intro and Resources 02:58 Why This 14 Day Fast Works 03:27 Visceral vs Subcutaneous Fat 04:20 Days 1 to 3 14 10 Plan 06:21 Days 4 to 6 16 8 Upgrade 07:20 Days 7 to 13 18 6 Autophagy 09:40 Day 14 24 Hour Fast 11:18 Eating Rules During Windows 14:05 Supercharge Your Fast 18:58 Breaking Your Fast Right 21:02 Common Fasting Questions 28:17 Hunger Hacks and Ghrelin 29:40 Will Weight Come Back 30:24 Safety and No Failed Fast 31:48 Protocol Recap and Results 33:42 Final Thanks and Outro   Glutathione is your body's master antioxidant, protecting your cells from oxidative stress and supporting your natural detoxification processes, but the way you take it matters. Purality Health's glutathione skips the capsule entirely. You spray it right onto your tongue, it's formulated with their advanced delivery technology, and they've added extra vitamin C. Right now Purality Health is offering a buy one get one free special backed by a 180-day money back guarantee. Visit masterantioxidant.com/drj to access this exclusive deal. A lot of skincare looks good on paper but doesn't deliver, and most brands will tell you that you need ten different products for an effective routine. OneSkin was founded by longevity researchers who asked a better question: if visible skin aging is driven by damaged senescent cells, what if you could slow that process at the source instead of covering it up?  That research produced OS-01, OneSkin's proprietary peptide and the first ingredient proven to switch off damaged senescent cells. It's backed by four peer-reviewed clinical studies on efficacy and safety across all skin types, over 10,000 five-star reviews, and recognition from Bloomberg as a leader in skin longevity. Go to oneskin.co/drjockers and use code doctorjockers for 15% off.   "There's no such thing as a failed fast. Every fast is going to move you in the direction of healing." ~ Dr. Jockers     Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean TuneIn Radio     Resources: Visit masterantioxidant.com/drj to get a buy one get one free special on Purality Health glutathione, backed by a 180-day money back guarantee Visit oneskin.co/drjockers and use promo code doctorjockers to get 15% off OneSkin Download Dr. Jockers' 7-Day Fat Burning Quick Start Guide – https://drjockers.lpages.co/7-day-quickstart-guide-opt/ Life Boost Coffee, Dr. Jockers' mycotoxin-free coffee of choice – https://lifeboostcoffeellc.pxf.io/6kdVrE Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https:/www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/   If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/ 

What if fibromyalgia, chronic fatigue, and chronic Lyme were not separate diseases at all, but one problem wearing different masks? Dr. Bill Rawls, MD, co-founder and medical director of Vital Plan, got so sick in his forties that conventional medicine could not reach him. He rebuilt himself from the cell up with herbs, and he now argues that your cells carry dormant microbes for decades, and that health comes down to whether those cells can keep clearing house. This episode lays out the cellular picture of chronic illness and the herbs that hold it in check. Meet our guest Dr. Bill Rawls, MD is a number-one bestselling author (Unlocking Lyme, The Cellular Wellness Solution) and the founder of Vital Plan, where he developed the RESTORE180 herbal protocol. After a chronic-Lyme crisis, he restored his health through botanical medicine and has spent over a decade piecing together the research on how cells and microbes drive chronic illness. Thank you to our partners Outliyr Biohacker's Peak Performance Shop: get exclusive discounts on cutting-edge health, wellness, & performance gear Ultimate Health Optimization Deals: a database of of all the current best biohacking deals on technology, supplements, systems and more Latest Summits, Conferences, Masterclasses, and Health Optimization Events: join me at the top events around the world FREE Outliyr Nootropics Mini-Course: gain mental clarity, energy, motivation, and focus Key takeaways Chronic illness is one problem in disguise: cellular stress impairs autophagy and lets dormant microbes reactivate. About 60% of all microbe mass on Earth is dormant at any moment. 95% of people carry Epstein-Barr and at least 60% carry Toxoplasma, usually without symptoms. Antibiotics depend on fast growth, so they struggle against slow microbes like Borrelia. Herbs carry hundreds of compounds, so microbes never develop resistance, and they spare the gut and mitochondria. Adaptogenic antimicrobials like Japanese knotweed and cat's claw can be taken long term. Start with turmeric, boswellia, and reishi on a base of sleep, plant diversity, and movement. Episode highlights 1:54 Why cells are the real root of chronic illness 15:21 Dormant microbes living in your cells for decades 24:53 Autophagy: your cells' cleanup crew and defense 46:45 Why antibiotics fail against stealth microbes 51:20 The boiling point and rebuilding with herbs 58:38 Adaptogens vs adaptogenic antimicrobials 1:10:14 Where to start: herbs, dose, and the basics Links Watch it on YouTube: https://youtu.be/V4GoxN31sUQ  Full episode show notes: https://outliyr.com/278 Connect with Nick on social media Instagram Twitter (X) YouTube LinkedIn Easy ways to support Subscribe Leave an Apple Podcast review Suggest a guest Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you! Be an Outliyr, Nick

Fasting gets a lot of attention for what happens while you're not eating, but what happens when you start eating again deserves just as much attention.In this solo episode, Dr. Mindy breaks down one of the most overlooked parts of fasting: the refeed.She explains why longer isn't always better when it comes to fasting, how the eating and fasting windows work together, and why protein, carbohydrates, fiber, fermented foods, and plant diversity can all have a place in your fasting rhythm.She also takes on some of the biggest conversations happening around fasting right now, including thyroid health, muscle loss, the gut microbiome, fasting after 45, GLP-1, autophagy, meal timing, and whether women really need to eat protein first thing in the morning.In This EpisodeWhy fasting longer isn't necessarily fasting betterWhy your first meal after a fast deserves more attentionWhat happens to thyroid hormones during extended fasting and refeedingWhy carbohydrates and protein matter after longer fastsWhat fasting may change within your gut microbiomeWhy plant diversity and fermented foods matter during your eating windowThe debate around fasting for women over 45Why Mindy cycles fasting rather than using the same fasting window every dayWhether you really need protein immediately after wakingHow to experiment with an eating window that works for your body and lifestyleThe difference between your sugar-burning and fat-burning statesHow nutrients can stimulate your body's natural GLP-1 responseFor more resources related to today's episode, visit the podcast episode page: drmindypelz.com/370 Connect with Dr. Mindy:Join Reset AcademyWatch the episodes on YouTubeFollow Dr. Mindy on InstagramSubscribe to Dr. Mindy's newsletterDisclaimer: This podcast is intended for educational and informational purposes only and is not a substitute for professional medical advice. Always consult a qualified healthcare professional before making changes to your diet, fasting routine, or lifestyle.

Innate–Adaptive Balance and BWH 85 Beta-Glucan with Functional Medicine Physician Dr. Rob Rountree: He brings a nuanced view of immunity that rejects the simple “immune boosting” dimmer-switch model and emphasizes immune regulation and readiness. He reviews innate immunity as sentinel cells using pattern recognition receptors (e.g., macrophages) and explains how innate and adaptive systems interface, with innate signaling training adaptive responses; chronic inflammatory disease is framed as rooted in innate dysregulation. He reveals how immune responses can both protect and harm (candida, cytokine storm concerns during COVID) and why test-tube “stimulation” doesn't equal human effects. The focus is a purified brewer's yeast (Saccharomyces cerevisiae) beta-1,3/1,6-glucan (BWH 85, 85% purity), its triple-helix structure, receptors (Dectin-1, CR3), dosing (100–500 mg), evidence for improving vaccine response in elders, and potential relevance for autoimmunity, athletes, and cancer surveillance alongside lifestyle and key nutrients like vitamins A, C, D and zinc.

Most of us assume that if something serious was happening inside our body, we would know. We would feel sick. Something would hurt. A blood test would catch it. But some health problems can develop quietly for years, and sometimes the clue that finally gets your attention is sitting right where you can see it: on your skin.In this episode of Biohacking Beauty, we get into the skin changes that can point to something happening beyond the surface, from psoriasis and multiple skin tags to persistent rashes, hair loss, and subtle signs of skin cancer. We also talk about what makes a dermatologist look deeper, how long sun damage can build before it becomes visible, and when a skin concern deserves more than another product or treatment.Dr. Mamina Turegano is a triple board-certified dermatologist, internist, and dermatopathologist, giving her a unique perspective that connects what is happening on the skin with what may be happening throughout the body. Her background in internal medicine and dermatopathology allows her to look beyond the appearance of a skin change and consider the metabolic, autoimmune, inflammatory, and systemic conditions that may be connected to it.What's Discussed:(01:25) Why you can feel perfectly healthy while something is already changing internally.(02:48) Why psoriasis can warrant looking at cardiovascular and metabolic health too.(04:49) What multiple skin tags may tell you about insulin resistance.(16:07) When an unexplained rash or chronic itching deserves a deeper workup.(19:18) The skin cancer signs people may overlook and when hair loss needs more attention.(23:14) How sugar, alcohol, stress, sleep, and circadian disruption can accelerate skin aging.(35:31) Why Dr. Mamina is comfortable with topical peptides but not injectable peptides yet.(45:24) Whether Google, AI skin scanners, and self-diagnosis are helping or hurting.(48:53) How long sun damage may be building before you finally see it.Listen to this episode of Biohacking Beauty to learn which skin changes are worth paying closer attention to, and why treating what you see is not always the end of the conversation.Resources mentioned:Want to find out more about Autophagy? Listen here: The Overlooked Side of Autophagy Causing Aging - Part 1The Overlooked Side of Autophagy Causing Aging - Part 2Find more from Young Goose:Website: younggoose.comUse code PODCAST10 to get 10% OFF your first purchase, and if you're a returning customer use code PODCAST5 to get 5% OFF.Instagram: @young_goose_skincareFind more from Dr. Mamina Turegano:Website: DrMamina.com Instagram: @dr.maminaTikTok: @dr.maminaYouTube: @dr.mamina

In this episode, Dr. David Jockers sits down with Dr. Sara Pugh, who holds a PhD in molecular mechanisms and was the first board-certified quantum biologist, for a conversation about the health input almost nobody is optimizing: light. Quantum biology, as she explains it, is simply looking at health through light, water, and magnetism, with a heavy focus on the mitochondria and the electrons that carry our life force.   You will learn why the specific blend of red, blue, and violet light at sunrise sets your body clocks and switches on hormonal cascades in the pituitary gland, why glass blocks roughly half the red light and all of the grounding benefit, how UVA builds the serotonin you will convert to melatonin later, and when UVB is actually available to make vitamin D from cholesterol. Dr. Pugh and Dr. Jockers also dig into the sunscreen and sunglasses debate, the dietary strategies that build real sun tolerance, and why DHA is a quantum molecule that can turn light into electricity and back again.   From there the conversation turns to Dr. Pugh's nine-day water fast, why she ended it a day early when her leptin came back at 0.7, what refeeding after an extended fast actually requires, and how sauna, cold plunges, and other hormetic stressors build resilience when the dose is right.   In This Episode:  00:00 Flying and Clot Risk 02:38 Meet Dr Sara Pugh 03:27 Quantum Biology Explained 04:49 Why She Got Into It 06:34 Sunrise and Body Clocks 08:29 Sunrise Indoors vs Outdoors 09:57 Morning Ritual and Awe 13:01 Sunset and Sleep Signals 15:07 Evening Light Hygiene Tips 17:24 UVA UVB and Vitamin D 20:44 Sunscreen and Sunglasses Debate 25:15 Dietary Sun Protection 26:38 Omega 3 DHA and EZ Water 29:54 Airplanes Dehydration and Flow 31:42 Structured Water and Fresh Fruit 34:46 Seasonal Eating and Summer Sun 35:22 Muscadines and Gut Fuel 36:23 Fasting Boosts Akkermansia 36:47 Nine Day Fast Experiment 39:30 Low Leptin Explained 44:02 Symptoms and Lab Testing 46:15 Refeeding After Long Fasts 51:30 Sauna for Autophagy 55:37 Cold Face Plunge Benefits 58:45 Hormesis and Cortisol Balance 01:01:37 Carbs Keto and Mitochondria 01:03:52 Wrap Up and Takeaways   Turmeric is one of the most potent natural ways to calm inflammation, shutting down the NF-κB and STAT3 pathways behind so many chronic issues. Paleovalley Turmeric Complex uses whole food organic turmeric rather than isolated curcumin, plus coconut oil and black pepper, a pairing shown to increase absorption by 2,000%. Go to paleovalley.com/jockers for 15% off your order.   Ten minutes a day is all the BON CHARGE Red Light Face Mask asks. Red and near-infrared wavelengths support your skin's texture, tone, and elasticity, it suits every skin type, and it is lightweight and cordless enough to travel with. Go to boncharge.com with promo code DRJOCKERS for 15% off, plus free shipping and a 12-month warranty.   Most of us do not eat enough fatty fish, and plenty of the fish oil on the shelf is already rancid or mostly filler. AquaOmega delivers one of the highest EPA and DHA concentrations per serving, made exclusively from anchovies, batch-tested for purity and freshness, and Friend of the Sea certified. No fish burps, and every bottle sold pulls a pound of plastic from the ocean. Go to myaquaomega.com/jockers and use code JOCKERS for 20% off.   Healthy eating gets a lot simpler when quality protein is already in the freezer. ButcherBox delivers over 100 options straight to your door, including 100% grass-fed beef, free-range organic chicken, crate-free pork, and wild-caught seafood, on a plan you customize. Go to butcherbox.com/drjockers for $20 off your first box, plus your choice of free ribeye, New York strip, or filet mignon in every box for a year, with free shipping always. "Poor light exposure, something called malillumination, is to the body what malnutrition is to the body."   Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean  TuneIn Radio   Resources:  Visit paleovalley.com/jockers to get 15% off Paleovalley Turmeric Complex and other products Visit boncharge.com and use promo code DRJOCKERS to get 15% off the BON CHARGE Red Light Face Mask, plus free shipping and a 12-month warranty Visit myaquaomega.com/jockers and use code JOCKERS to get 20% off AquaOmega Visit butcherbox.com/drjockers to get $20 off your first box, plus your choice of free ribeye, New York strip, or filet mignon in every box for a year, and free shipping     Connect with Dr. Sara Pugh: Website: https://busysuperhuman.com/ Instagram: https://www.instagram.com/busy_superhuman/ TikTok: https://www.tiktok.com/@busysuperhuman YouTube: https://www.youtube.com/@Thebusysuperhuman Substack: https://drsarapugh.substack.com/ Podcast: https://podcasts.apple.com/us/podcast/the-quantum-based-podcast-with-dr-sara-pugh/id1787588995   Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https:/www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/   If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/

Welcome to the latest episode in our series of highly vetted companies I like to share with my Everyday Wellness community. Today, I'm delighted to connect with Leslie Kenny, Founder and CEO of Oxford Healthspan. After being diagnosed with multiple autoimmune conditions and being told she was unlikely to have any biological children, Leslie put her autoimmune conditions into remission through nutrition and lifestyle changes and later went on to conceive naturally at 43. Her personal experience led her into a research collaboration with Oxford immunologist Professor Katya Simon, where she was introduced to spermidine, a naturally occurring polyamine studied for its role in autophagy—our cells' internal recycling and cleanup process. She later founded Oxford Healthspan to bring a whole-food Japan-sourced spermidine supplement, Primadine, to market. She also co-founded the non-profit Oxford Longevity Project alongside Oxford scientists to educate the public more broadly on healthspan research. In our conversation, we discuss self-advocacy, autoimmunity, infertility, and empowerment, exploring how modern life affects perimenopause and menopause, as well as spermidine research and its mechanisms of action. We discuss intermittent fasting, autophagy, mitophagy, gut health, food-based sources of spermidine, how our spermidine levels decrease with age, and why supplementation is truly beneficial. Leslie also shares feedback on how Primadine impacts memory, cognition, hair, skin, and nails; how clock genes and circadian biology work; and biological versus chronological age. Stay tuned for a truly fascinating conversation with Leslie Kenny- one you'll most likely want to revisit more than once. IN THIS EPISODE, YOU WILL LEARN: The changes Leslie implemented after being diagnosed with rheumatoid arthritis and lupus  How patients need to ask questions and collaborate with their clinicians rather than simply following instructions  Leslie describes how she worked with doctors to monitor her symptoms and address problems early during the perimenopause-to-menopause transition. How Leslie came to learn about spermidine and its connection to autophagy and mitophagy How spermidine can support healthy aging How ultra-processed foods can affect the gut, and foods that contain natural sources of spermidine  The types of improvements customers taking Primadine have reported Leslie explains the distinction between biological and chronological age Why intermittent fasting, although beneficial, may not work the same way for all women Bio:  Leslie Kenny is an Oxford-based longevity entrepreneur, TEDx Oxford speaker, and healthspan advocate. She is the founder of Oxford Healthspan, creator of Primeadine®, co-founder of the Oxford Longevity Project, and Global Executive Ambassador for the Japan Autophagy Consortium, whose senior adviser is Yoshinori Ohsumi, recipient of the 2016 Nobel Prize in Physiology or Medicine for his pioneering research on autophagy. She is a frequent international speaker and moderator on longevity, biological aging, and the future of preventive medicine, with a particular focus on translating emerging research into practical, evidence-based strategies for extending healthspan. Leslie has been an early advocate for the role of autophagy, cellular renewal, and nutrition in healthy aging, helping to pioneer broader awareness of spermidine and its relevance to longevity pathways. Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website. Submit your questions to support@cynthiathurlow.com  Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow.  Purchase Cynthia's book, The Menopause Gut. Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Connect with Leslie Kenny Oxford Longevity Project Oxford Healthspan - Use discount code CYNTHIATHURLOW for 20% off your first Oxford Healthspan order Leslie's New Prime

Alan Goldhamer, D.C., separates fasting facts from common fallacies, explaining what fasting can and cannot do for health. Learn how fasting may affect metabolism, weight, inflammation, and chronic disease risk, while understanding the importance of safety and proper supervision. #Fasting #MetabolicHealth #Wellness

This week on the Colman Power Organic Fitness Podcast, I'm joined by Loren Lockman all the way from the USA for a fascinating conversation about fasting, water fasting, autophagy, nutrition and the body's ability to heal.Loren has spent decades working with fasting and has worked with more than 16,000 clients from 156 countries.We get into what actually happens when you stop eating, what autophagy is, why Loren believes it really starts to become significant beyond the 16–18 hour mark, how the body moves from glucose to glycogen and then towards fat and ketones, and why he believes longer fasting can create some remarkable results.We also talk about breaking a fast, whole foods versus juices, protein, fruit, coconut water, our evolutionary history and why Loren believes humans are tropical animals regardless of where we live.It's a fascinating and definitely thought-provoking conversation, with some views that I know will challenge the conventional way of thinking about health and nutrition.Loren also shares some incredible stories from his clients and explains why he believes fasting is incredibly powerful — but also why it has to be done properly.A unique one this week. Enjoy!

In this episode, Dr. David Jockers sits down with Vanessa Spina, sports nutrition specialist, bestselling author of Keto Essentials, creator of the Tone ketone breath analyzer, and host of the Optimal Protein Podcast, for a deep dive on a groundbreaking new study out of the University of Nottingham, published in Clinical Nutrition in August 2025. You will learn why the old "you can only absorb 30 grams of protein per meal" rule doesn't hold up, what really happens to protein you eat beyond that amount, and why the popular anabolic-window advice to slam a shake right after your workout is largely a myth. Dr. Jockers and Vanessa then break down a randomized, controlled fasting-mimicking diet study that overturns the long-held belief that high protein blocks autophagy, and explain why a high-protein, calorie-restricted approach can outperform a low-protein one for visceral fat loss, ketone production, and metabolic health.  They close with a practical, hour-by-hour walkthrough of the protein-sparing modified fast (PSMF): what to eat, how much protein to target, how to structure refeed days, and how it compares to water fasting and Ozempic for appetite control.   In This Episode:  00:00 Protein Absorption Myth 00:14 Episode Intro and Study Teaser 05:29 Meet Vanessa and Study Setup 07:35 100g Protein Study Breakdown 12:17 Protein Timing and Real Life 17:48 Protein First for Satiety 23:55 Ketones and High Protein Keto 28:10 Stress Hormones and Growth Hormone 31:58 Autophagy Study Lead In 33:12 Why Human Trials Matter 34:52 Autophagy Headlines vs Reality 35:54 High Protein FMD Study Setup 39:01 Autophagy Still Upregulated 40:53 Visceral Fat and Metabolic Wins 44:12 PSMF One Day Weekly 44:58 Vanessa PSMF Results 47:22 Meals Macros and Refeeds 51:21 Ketones Hunger and Ozempic 55:27 Weekly Schedule and Whoosh 58:26 PSMF Meal Ideas and Tips 01:04:06 Water Fast vs PSMF 01:05:54 Wrap Up and Where to Find 01:06:56 Final Listener Outro   This podcast is sponsored by Paleo Valley's Turmeric Complex, a whole-food organic turmeric formula (not just isolated curcumin) blended with coconut oil and black pepper for absorption, plus ginger, rosemary, and cloves for extra anti-inflammatory and brain-support benefits. Go to paleovalley.com/jockers for 15% off your order.   A new season is the perfect time for fresh routines, and iRestore has led the way in red-light therapy for over two decades, trusted by more than 500,000 customers worldwide. The iRestore Elite laser hair growth system uses 300 lasers and 200 LEDs to help regrow thicker, healthier hair in as little as three months, and the Illumina face mask pairs triple-wavelength light therapy with a lightweight, cordless design to target fine lines, breakouts, and dullness in just 10 minutes a few times a week. Head to iRestore.com and use code DRJOCKERS for Labor Day savings on the Elite and Illumina bundle.   Tired of leaving a doctor's visit with more questions than answers? SuperPower Health runs one simple blood draw covering over 100 biomarkers — heart, liver, thyroid, hormones, metabolism, vitamins, minerals, and environmental toxins — and tracks your results over your lifetime with an on-demand clinician team to help you interpret them. Go to superpower.com and use code JOCKERS for $20 off your membership.   MasterClass keeps adding new classes, so there's never been a better time to get in. Right now, as a listener of this show, you get at least 15% off any annual membership at MASTERCLASS.com/DRJOCKERS. That's 15% off at MASTERCLASS.com/DRJOCKERS.  "Optimizing your protein acts just as well, if not better, than taking a semaglutide medication — without those side effects and a fraction of the cost."   Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean  TuneIn Radio   Resources:  Visit paleovalley.com/jockers to get 15% off Paleo Valley's Turmeric Complex and other products Visit iRestore.com and use code DRJOCKERS for Labor Day savings on the iRestore Elite and Illumina face mask bundle Visit superpower.com and use code JOCKERS to get $20 off your SuperPower Health membership Visit masterclass.com/drjockers to get at least 15% off any annual MasterClass membership Study referenced: The effects of a short-term (1-week) very low-calorie diet comparing low and normal protein content on cardiometabolic outcomes, glucose metabolism and autophagy — University of Nottingham (Clinical Nutrition, August 2025)     Connect with Vanessa Spina: Website: ketogenicgirl.com Instagram: https://www.instagram.com/ketogenicgirl/ Podcast: https://podcasts.apple.com/podcast/id1344681226   Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https:/www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/   If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/

In this episode, Dr. David Jockers breaks down fasting as the most powerful natural anti-inflammatory tool available, walking through a detailed hour-by-hour timeline of what happens inside your body, from the first 12-hour gut and liver reset all the way out to the deep cellular healing of a 3-to-5-day fast. You will learn exactly what your body is doing at each checkpoint of a fast, from the metabolic switch into fat burning at 14 hours, through the onset of autophagy and BDNF-driven mental clarity, to the dramatic rise in human growth hormone at 24 hours, the gut microbiome shift at 36 hours, and the full immune system rejuvenation that unfolds between 48 and 72 hours. Dr. Jockers also lays out a practical, step-by-step way to build up to longer fasts safely.   In This Episode:  00:00 Gut Healing Teaser 00:18 Podcast Welcome and Support 03:55 Why Fasting Beats Inflammation 05:09 12 to 14 Hour Kickoff 07:01 16 to 24 Hour Deep Repair 14:20 24 to 36 Hour Youth and Gut Reset 16:02 36 to 72 Hour Ketosis and Immunity 18:31 3 to 5 Day Max Healing 19:27 How to Start Fasting Safely 22:16 Wrap Up and Next Steps 23:17 Podcast Closing and Reviews   Pure Health Research offers 45 premium health supplements built for every health goal — energy, belly fat, healthy blood sugar, testosterone support, or reducing leg swelling. Every formula uses natural, non-GMO ingredients backed by clinical research and is manufactured in the USA. Go to purehealthresearch.com and use coupon code JOCKERS for 35% off, backed by a 365-day money-back guarantee.   Many conventional cleaning products carry synthetic fragrances, phthalates, and harsh surfactants linked to hormone disruption. Branch Basics makes human-safe cleaning products with no fragrance or hormone disruptors, screened against thousands of known and suspected harmful chemicals. The concentrate mixes into cleaners for every room, and the line also includes dishwasher tablets and a fragrance-free laundry detergent. Find Branch Basics at Target, Amazon, or branchbasics.com, and use code DRJOCKERS for 15% off the premium starter kit.   "Autophagy is triggered by the absence of food, not by the presence of something. You can't supplement your way into autophagy."  ~ Dr. Jockers     Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean TuneIn Radio     Resources: Visit https://purehealthresearch.com and use coupon code JOCKERS to get 35% off Pure Health Research supplements, backed by a 365-day money-back guarantee Visit https://branchbasics.com and use code DRJOCKERS to get 15% off the Branch Basics premium starter kit     Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https://www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/ If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/ 

In this Huberman Lab Essentials episode, my guest is Dr. Chris Palmer, MD, a board-certified psychiatrist and Assistant Professor of Psychiatry at Harvard Medical School. We explain how nutrition and metabolism directly affect mental health, including the biological mechanisms underlying these effects. We also discuss how carbohydrate restriction, ketogenic diets and fasting can improve mood, energy, and, in some cases, treatment-resistant psychiatric conditions. Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman BetterHelp: https://betterhelp.com/huberman Timestamps (00:00:00) Chris Palmer (00:00:20) Personal Story, Nutrition & Mental Health (00:05:28) Treatment-Resistant Mental Disorders & Low-Carbohydrate Diet (00:07:32) Sponsor: Eight Sleep (00:08:51) Ketogenic Diet & Schizophrenia Success Story (00:12:20) Nutrition for Mental Disorders, Ketosis, Highly Processed Foods (00:15:13) Epilepsy & Ketogenic Diet, Fasting; Mitochondrial Benefits (00:21:14) Sponsor: BetterHelp (00:22:15) Mitochondria Functions, Mental Disorders (00:28:05) Mitophagy, Autophagy, Longevity & Calorie Restriction (00:33:12) Sponsor: AG1 (00:34:25) Carbohydrate Restriction, Depression Treatment (00:37:23) Acknowledgements Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

Healthy skin isn't built in your bathroom—it's built inside your body. While most people focus on creams, collagen powders, and cosmetic treatments, the biggest drivers of wrinkles, sagging, and loss of elasticity are happening at the cellular level. In today's episode, I discuss: Why blood sugar may be aging your skin faster than the sun and the hidden process that damages collagen from the inside out The surprising connection between muscle, metabolism, and firmer, healthier-looking skin (especially after weight loss) How your body's natural cellular repair system helps slow the aging process and the habits that activate it The biggest everyday factors accelerating skin aging, and the science-backed strategies that help protect your skin for years to come Healthy skin isn't something you can simply apply—it's something your body creates. By improving your metabolic health, protecting collagen, building muscle, reducing inflammation, and supporting your cells, you can help your skin stay stronger, healthier, and more resilient from the inside out. Resources Mentioned: Environmental Working Group (EWG): https://www.ewg.org/areas-focus/personal-care-products Track your health with Function Health: https://functionhealth.com/mark (Use code MARK2026 for $50 off your membership.) Have a question you'd love answered on Office Hours? Submit it here (0:00) Understanding Skin Aging and Its Causes (1:24) Sponsor: Function Health (2:04) Chronic Inflammation, Blood Sugar, and Glycation in Skin Aging (6:01) Autophagy and Lifestyle Habits for Skin Health (9:31) The Role of Muscle and Managing Loose Skin (12:11) Sun Exposure, Protection, and Skin Aging (14:35) Rapid Fire: Common Skin Health Questions

Laila Ali spent years training to win. As an undefeated professional boxer, her body was her career. She knew exactly how to train harder, eat less, and make weight when she needed to. Then perimenopause changed the rules.In this episode of Live Like a Girl, Laila joins Dr. Mindy for an honest conversation about what happened when her old strategies stopped working, why she eventually stopped trying to outwork her hormones, and how fasting helped her build a completely different relationship with her body.They talk about long fasts, exercising while fasting, food noise, refeeding, sugar cravings, body image, the scale, stress, and what it means to train for health instead of performance.Laila also shares how she talks to her teenage daughter about fasting, why she refuses to make healthy eating feel like punishment, and the lesson she learned from becoming a boxer against Muhammad Ali's wishes: sometimes the most important thing you can do is listen to the spark inside you.In this episode, you'll learn:Why Laila stopped trying to outwork her hormonesHow fasting changed her relationship with food and controlWhat she learned from doing longer fastsHow she exercises during a fastWhy refeeding matters after an extended fastHow she thinks about weight, muscle, and body image nowWhy stress can derail even strong health routinesHow she talks to her daughter about fastingWhy she no longer counts macrosWhat Muhammad Ali taught her about following your own path__Resources & Supplements MentionedA Spark of Greatness by Laila AliLaila's Organic Spice BlendsZero Fasting AppFast Like a GirlQualia Creatine+ (use code MINDY for 15% off)Infrared SaunaRed Light TherapyElectrolytes Bone Broth (use code MINDY10 for 10% off)__More on Laila AliA Spark of Greatness by Laila AliLaila's Organic Spice BlendsFood for Life by Laila AliWebsite: lailaali.comInstagram: @thereallailaaliFacebook: @LailaAliFor more resources related to today's episode, visit the podcast episode page: drmindypelz.com/ep361__Connect with Dr. Mindy:Join Reset AcademyWatch the episodes on YouTubeFollow Dr. Mindy on InstagramSubscribe to Dr. Mindy's newsletter for tools and research on fasting, hormones, and metabolic healthDisclaimer: This podcast is intended for educational and informational purposes only and is not a substitute for professional medical advice. Always consult a qualified healthcare professional before making changes to your diet, fasting routine, or lifestyle.

Are you eating well, moving your body, and trying to sleep better — but still feeling older than you should? Stiffer joints, lower energy, and a sense that the last few years have aged you faster than the years before? That feeling has a cause, and it is not laziness or bad genetics. In this episode, we dive into why aging happens inside your cells first, and how your body catches up later. I walk through the 4 specific drivers that accelerate cellular aging and the 5 evidence-backed levers you can use to slow — and in some cases reverse — that process. Stay until the end for the clinical trial where participants did not just slow cellular aging… but after five years, they measurably turned it backward. In this episode, you'll learn: • Why your biological age — not the number on your driver's license — determines how you feel, think, and move • The 4 key mechanisms breaking down your cells right now, including telomere shortening, mitochondrial decline, slowed autophagy, and senescent cell buildup • How telomeres work like the plastic tips on a shoelace, and why emotional stress wears them down faster than almost anything else • What autophagy is, why your cellular cleanup crew slows with age, and how to switch it back on • Why resistance training is the single most powerful tool for building new mitochondria and slowing cellular aging • The specific fats that keep your cell membranes flexible and springy — and the ones that make them brittle • How deep sleep triggers growth hormone release, clears damaged proteins, and runs the brain's overnight repair cycle • The 9 blood biomarkers from a 2018 study in the journal Aging that predict longevity better than chronological age • The five-year lifestyle trial where one group lengthened their telomeres by 10% while the control group's shortened by 3% Find out what's really happening inside your body with advanced at-home biomarker testing — which includes a 60 minute consultation to review your results and learn about our cellular healing protocols at The Health Institute → http://mybloodwork.com Thank you to our sponsors! Sunlighten Sauna: https://get.sunlighten.com/axepodcast Manukora Manuka Honey: https://manukora.com/axe Watch The Dr. Josh Axe Show every Monday & Thursday on YouTube: https://www.youtube.com/@drjoshaxe?sub_confirmation=1

Is intermittent fasting biohacker wellness hype or legit health intervention? Some studies show real benefits, others find nothing, and the occasional headline calls it bad for your heart.Dr. Courtney Peterson has spent nearly two decades running some of the field's most tightly controlled feeding trials, and her data points to a clear pattern: there is a real effect to a restricted eating window, but when you eat may matter as much as how long you fast. Her studies found that eating in a short window early in the day lowers blood pressure and improves insulin sensitivity, even without weight loss. A physicist by training, she brings that same rigor to a field built mostly on people's own food diaries.Free course: Improve your metabolic healthGet our free email course on how glucose, nutrition, exercise, sleep, and measurement can help you build habits that support better energy and long-term health: ⁠⁠⁠⁠⁠⁠⁠⁠⁠https://levels.link/wnl⁠

He outlines the benefits of supervised fasting for inflammation and healing while warning against dangerous trends like dry fasting. #FastingBenefits #SafeDetox #InflammationRelief #HealthTalks

Get The Fasting Delusion here: Amazon.com link: https://www.amazon.com/dp/1916393055 Amazon.co.uk link: https://www.amazon.co.uk/dp/1916393055 Amazon.ca link: https://www.amazon.ca/dp/1916393055 Amazon.com.au link: https://www.amazon.com.au/dp/1916393055 Amazon.es link: https://www.amazon.es/dp/1916393055 Amazon Ireland: https://www.amazon.ie/dp/1916393055---Are you following health trends that actually harm your health? In my eye-opening masterclass "The 7 Popular But Deadly Health Fads," I reveal how common health practices promoted by influencers and gurus might be ravaging your gut, accelerating disease, and shaving years off your life.Discover which popular diets, supplements, and health rituals are secretly sabotaging your health and learn what to do instead. I explain why these seemingly healthy habits are damaging your body and provide actionable alternatives for true longevity.Register for free access to this essential health information athttps://www.livelongerformula.com-------------Check out the first volume in the How to Actually Live Longer book series on Amazon: https://amzn.to/4dDXjxc

Asymptomatic individuals with hidden cardiometabolic risk can optimize longevity through periodic fasting and data-driven interventions. #PreventiveFasting #HealthyAging #Longevity

What if chronic illness isn't caused by the infection everyone is trying to eliminate? On this episode of The Longevity Formula, Dr. Brandon Crawford sits down with physician, bestselling author, and chronic illness expert Dr. Bill Rawls, MD, to challenge one of modern medicine's core assumptions: that killing the pathogen is the path to recovery.After his own collapse from Lyme disease, mold exposure, and burnout, Dr. Rawls abandoned symptom-chasing medicine to study cellular health, impaired autophagy, and what he calls "terrain." He explains why Lyme, long COVID, autoimmune disease, mold illness, and fibromyalgia may all trace back to the same broken mechanism.Follow Dr. Bill Rawls, MD:Facebook – facebook.com/rawlsmd/Instagram – instagram.com/rawlsmd/LinkedIn – linkedin.com/in/bill-rawls-md/YouTube – youtube.com/@rawlsmdWebsite – rawlsmd.com/resources/Products:528 Innovations LasersNeuroSolution Full Spectrum CBDNeuroSolution Broad Spectrum CBDNeuroSolution StimpodSTEMREGEN®For more information, resources, and podcast episodes, visit tinyurl.com/3ppwdfpm

Could you please comment on the new study that finds protein restriction could slow aging?Considerations for protein intake across the lifespanMy bone mineral density has improved with strontium. Should I stop taking it?  What about vitamin K2?

When did you last actually let yourself feel hungry? Not the "due for a snack" kind. Properly, deliberately hungry, on purpose. If you can't remember, you're not alone. Now imagine using that discomfort as a lever instead of avoiding it.Every reflexive snack, every meeting that runs straight into the next, every bite you take before your body even asks for it keeps you running on one setting. You never give your body the signal to switch fuel sources, sharpen your focus, or clean house at a cellular level. The fog, the afternoon slump, the stubborn weight that won't shift: that's the bill for never stopping.Dr Tom Buckley has spent more than 22 years reading the bloodwork of Performance Intelligence's executive clients, translating what's happening inside hundreds of high performers into how they eat, train, and lead. He's back on the podcast to explain what fasting actually does inside your body, why the meal you were told never to skip has a cereal company to thank for that reputation, and how two nights a week without dinner might be the highest-leverage habit in your week.You could keep running on constant fuel and wonder why your energy never settles. Or you could learn to use hunger as a lever instead of an enemy.03:35 The fat that's easiest to shift, and where it sits 05:41 Ghrelin, leptin and the people who never feel full 09:03 Three fuels, one easy habit: why carbohydrate wins by default 10:27 Metabolic flexibility: the skill Western living has trained out of us 16:08 The story that's driven Dr Tom for 35 years 21:47 What fasting switches off first 22:47 Ketones: the fuel that skips the insulin queue 25:13 Fasting and the new GLP-1 drugs are chasing the same biology 27:33 The shortcut risk: trading discipline for a jab 28:17 What decades of fasting research actually agree on 31:16 The benefits nobody puts on the label 33:21 Andrew's own Tuesday and Thursday fast, and why it finally clicked 36:01 The worst thing we do as humans, and the second worst thing 41:20 Autophagy: the cellular housekeeping everyone's talking about 44:22 Marvellous mitochondria, and why the name always gets a rerecord 45:00 The 18:6 protocol Dr Tom and Andrew actually live by 46:37 Why 6pm to midday captures most of the benefit 48:49 The client who fasted every day and undid his own progress 50:06 Why Dr Tom says don't pull this lever before your late 30s 51:39 David Sinclair's one-meal-a-day experiment 53:06 The 24-hour fast Dr Tom takes on international flights 54:50 Why women need a different rulebook entirely 58:29 Dirty fasting and dirty keto: the shortcut that costs you later 60:47 Dr Tom's cliff notes for the time-poor listenerWatch on Youtube: https://youtu.be/iiDAwpx78yoThe resource Dr Tom referenced for women's fasting protocols: Fast Like a Girl by Dr Mindy Pelz: https://fastlikeagirl.com/You can find Dr Tom at his LinkedIn: https://www.linkedin.com/in/tom-buckley-06a76b98/Listen to Dr Tom and Andrew talk GLP-1s: https://performanceintelligence.com/the-science-of-ozempic-and-what-happens-after-you-stop-dr-tom-buckley/ 

Water fasting helps reboot dopamine, reset the microbiome, and dramatically reduce cholesterol and lipoprotein(a)—even when diet alone doesn't work. #FastingReset #DopamineRecovery #LipoproteinA

In this episode of the Gladden Longevity Podcast, Dr. Gladden interviews Dr. Bill Rawls, who shares his transformative journey from conventional medicine to holistic healing. Bill discusses his struggles with chronic illness, particularly Lyme disease, and how he discovered the importance of cellular health and autophagy in recovery. He emphasizes the role of herbal therapies and adaptogens in promoting wellness and protecting cellular function, ultimately leading to a deeper understanding of chronic illness and aging. In this conversation, they explore the intricate connections between autoimmunity, chronic illness, and the role of microbial influences. They discuss the implications of long COVID, the benefits of adaptogenic herbs, and the importance of nervous system regulation in healing. The conversation emphasizes the need for a holistic approach to health, focusing on creating a supportive environment for healing and the potential of herbal medicine in managing chronic conditions.   For Audience Join the other 20,000+ high-performers getting weekly insights on biological reversal, exponential strategies, and Life Energy optimization→ https://start.gladdenlongevity.com/subscribe If you're ready to measure your 60+ biological ages and build a personalized reversal plan, apply for a discovery call here → https://start.gladdenlongevity.com/apply-now   Use code 'Podcast10' to get 10% OFF on any of our supplements at https://gladdenlongevityshop.com/!    Takeaways ·       Dr. Bill Rawls transitioned from conventional medicine to holistic healing due to personal health struggles. ·       Chronic Lyme disease was a pivotal point in Dr. Bill's journey, leading him to explore alternative therapies. ·       Understanding cellular health is crucial for addressing chronic illnesses. ·       Autophagy is a key process for cellular rejuvenation and health. ·       Herbal therapies can effectively support the body's healing processes. ·       Adaptogens help the body adapt to stress and promote resilience. ·       Impaired autophagy is linked to many chronic illnesses. ·       Dr. Bill emphasizes the importance of diet, sleep, and lifestyle in maintaining health. ·       Herbs can protect cells from stress and inflammation. ·       The journey of healing is often non-linear and requires exploration of various therapies. Autoimmunity may be driven by microbial invasion and immune response. ·       Long COVID symptoms could be linked to reactivation of dormant pathogens. ·       Adaptogenic herbs can support cellular health and stress management. ·       Nervous system regulation is crucial for effective healing. ·       Herbal preparations can be more effective than traditional medications. ·       Creating a healthy environment is essential for chronic illness management. ·       The body's stress response can exacerbate chronic health issues. ·       Herbs can provide a broad spectrum of benefits beyond just antimicrobial effects. ·       Education and environment play key roles in health improvement. ·       Chronic illness management requires a shift in healthcare focus.  Chapters 00:00 Dr. Bill Rawls' Journey from Conventional Medicine to Holistic Healing 05:12 Understanding Lyme Disease and Chronic Illness 10:46 The Role of Autophagy in Health and Disease 16:36 Herbal Therapies and Adaptogens in Healing 25:20 Protecting Cellular Health and Mitochondrial Function 26:20 Understanding Autoimmunity and Microbial Influence 28:02 Long COVID and Chronic Illness Connections 30:14 The Role of Adaptogenic Herbs in Healing 32:07 Nervous System Regulation and Healing 33:55 Herbal Preparations and Their Efficacy 37:54 The Broad Spectrum of Herbal Medicine 40:59 Creating a Healthy Environment for Healing 49:03 The Future of Health and Chronic Illness Management   To learn more about Dr. Bill Rawls:Facebook: https://www.facebook.com/rawlsmd/ Website: rawlsmd.com Instagram: https://www.instagram.com/rawlsmd/   Reach out to us at:    Website: https://gladdenlongevity.com/     Facebook: https://www.facebook.com/Gladdenlongevity/    Instagram: https://www.instagram.com/gladdenlongevity/?hl=en     LinkedIn: https://www.linkedin.com/company/gladdenlongevity    YouTube: https://www.youtube.com/channel/UC5_q8nexY4K5ilgFnKm7naw       Gladden Longevity Podcast Disclosures Production & Independence The Gladden Longevity Podcast and Age Hackers are produced by Gladden Longevity Podcast, which operates independently from Dr. Jeffrey Gladden's clinical practice and research at Gladden Longevity in Irving, Texas. Dr. Gladden may serve as a founder, advisor, or investor in select health, wellness, or longevity-related ventures. These may occasionally be referenced in podcast discussions when relevant to educational topics. Any such mentions are for informational purposes only and do not constitute endorsements. Medical Disclaimer The Gladden Longevity Podcast is intended for educational and informational purposes only. It does not constitute the practice of medicine, nursing, or other professional healthcare services — including the giving of medical advice — and no doctor–patient relationship is formed through this podcast or its associated content. The information shared on this podcast, including opinions, research discussions, and referenced materials, is not intended to replace or serve as a substitute for professional medical advice, diagnosis, or treatment. Listeners should not disregard or delay seeking medical advice for any condition they may have. Always seek the guidance of a qualified healthcare professional regarding any questions or concerns about your health, medical conditions, or treatment options. Use of information from this podcast and any linked materials is at the listener's own risk. Podcast Guest Disclosures Guests on the Gladden Longevity Podcast may hold financial interests, advisory roles, or ownership stakes in companies, products, or services discussed during their appearance. The views expressed by guests are their own and do not necessarily reflect the opinions or positions of Gladden Longevity, Dr. Jeffrey Gladden, or the production team. Sponsorships & Affiliate Disclosures To support the creation of high-quality educational content, the Gladden Longevity Podcast may include paid sponsorships or affiliate partnerships. Any such partnerships will be clearly identified during episodes or noted in the accompanying show notes. We may receive compensation through affiliate links or sponsorship agreements when products or services are mentioned on the show. However, these partnerships do not influence the opinions, recommendations, or clinical integrity of the information presented. Additional Note on Content Integrity All content is carefully curated to align with our mission of promoting science-based, ethical, and responsible approaches to health, wellness, and longevity. We strive to maintain the highest standards of transparency and educational value in all our communications.

"There's no such thing as a weight problem — it's a weight symptom." Ben Azadi joins Robert Lufkin MD to dismantle the calorie myth and reveal the metabolic root cause underneath stubborn fat, fatigue, and disease.Ben Azadi — functional health practitioner, founder of Keto Camp, and bestselling author of "Metabolic Freedom" — unpacks metabolic flexibility, diet variation, fasting, and why staying in ketosis forever can backfire. He previews his revised book "Keto Flex" (out July 21) and shares how he lost 80 pounds and rebuilt his metabolism from the inside out.Chapters:00:00 — Introduction01:30 — Ben Azadi's 80-Pound Transformation Story03:00 — What Was Actually Broken in His Metabolism06:00 — "You Don't Have a Weight Problem, You Have a Weight Symptom"07:30 — The 3 Percenters: Why 97% Chase Symptoms08:30 — Ask the Right Question: How Do I Lower Insulin?09:30 — Diet Variation: Why Cycling In and Out of Ketosis Works Better12:00 — Feast Day vs Cheat Day: Flexing to Healthy Carbs13:30 — Warning Signs You've Stayed in Keto Too Long15:00 — Hormesis, Stress, and the Post-Menopause Caveat16:30 — Using Heart Rate Variability to Dial In Your Stressors18:00 — The Carnivore "Toxin Terminator" and Plant Compounds22:30 — Chapter 9: A Customized Keto Plan for Women25:30 — Fasting, Autophagy, and mTOR Balance28:30 — How a 48-Hour Fast Resensitizes Your Dopamine Receptors30:00 — Where People Get Fasting Wrong (Don't Forget to Feast)33:00 — Metrics That Track Real Progress (Glucose, CGM, Oura)34:30 — AI, Wearables, and the End of One-Size-Fits-All Diets37:30 — What's New in the Revised Keto Flex40:30 — Metabolic Freedom vs Keto Flex: Which Book First?42:00 — Final Message: Identify the Interference, Let the Body HealKey takeaways:Weight is a symptom, not the problem — chase the root cause (insulin, inflammation, hormones), not the number on the scale.Metabolic flexibility beats rigid dieting: cycling in and out of ketosis with feast days keeps the body adaptive.Staying in ketosis indefinitely can backfire — watch for warning signs and build in strategic carb refeeds.Hormetic stressors (fasting, cold, exercise) help — but dose them to your recovery, tracked via HRV and tools like the Oura ring.A 48-hour fast can resensitize dopamine D2 receptors and reset reward signaling.Women often need a cyclical, customized keto approach — one-size-fits-all fails.Studies & sources:Fasting and dopamine D2 receptor availability — Dunn et al., Diabetes Care 2012 — diabetesjournals.orgKetogenic diet raises glutathione (hormesis / antioxidant defense) — Napolitano et al., Metabolites 2020 — pmc.ncbi.nlm.nih.govBen Azadi's revised book "Keto Flex" (bonuses) — ketoflexbook.comDr. Lufkin's book "Lies I Taught in Medical School": robertlufkinmd.com/lies⭐ Enjoying the show? Please leave a 5-star review on Apple Podcasts — it takes 30 seconds and helps more people discover the science of health and longevity. Thank you!New episodes every other Tuesday. Subscribe so you don't miss one.Continue this conversation on Substack: https://robertlufkinmd.substack.comLies I Taught In Medical School — Free sample chapter: https://www.robertlufkinmd.com/lies/Web: https://www.robertlufkinmd.comYouTube: https://www.youtube.com/robertlufkinmdX: https://x.com/robertlufkinmdInstagram: https://www.instagram.com/robertlufkinmd/TikTok: https://www.tiktok.com/@robertlufkinLinkedIn: https://www.linkedin.com/in/robertlufkinmd/

Join The Circle (use code PODCAST): ➡️ https://holplus.co/circle/Why are you always tired, even after getting enough sleep? If you wake up exhausted, struggle with brain fog, rely on caffeine, or lose your energy halfway through the day, the problem may begin inside your cells.In this solo episode of hol+, Dr. Taz explains why your body may be “biologically bankrupt,” meaning it is using energy faster than it can rebuild it. She breaks down three hidden causes of low energy: mitochondria that are not producing enough power, declining NAD levels, and old “zombie cells” that remain in the body and increase inflammation.You'll also learn simple ways to support your energy, including better sleep, moderate exercise, stress management, intermittent fasting, and nutrients such as magnesium, B vitamins, CoQ10, and quercetin.In this episode:Why you may still feel tired after sleepingHow your cells create energyThe connection between fatigue and brain fogWhat mitochondrial dysfunction meansWhy NAD matters for energy and cellular repairWhat “zombie cells” areHow inflammation drains your energyWhy caffeine and sugar only provide a temporary boostHow sleep and exercise help rebuild cellular energyPractical ways to stop running on emptyLearn more about hol+ and schedule an appointment:https://holplus.co/Listen to more episodes of the hol+ podcast:https://holplus.co/podcast/If you know someone who is always tired or struggling with low energy, share this episode with them. Subscribe for new episodes about hormones, gut health, inflammation, healthy aging, and whole-person healing every week.Stay Connected:Dr. Taz: https://www.instagram.com/drtazmd/Hol+: https://www.instagram.com/liveholplus/Hol+ Show: https://www.instagram.com/holplushow/Subscribe to the audio podcast: https://holplus.transistor.fm/subscribeSubscribe to the video podcast: https://www.youtube.com/@HolPlusShow/podcastsGet your copy of ➡️ The Hormone ShiftChapters00:00 Why Your Energy Never Seems to Last00:48 Chi, Prana and the Body's Energy01:49 Why Our Cells Are Running on Empty02:54 What Is Biological Bankruptcy?04:01 The 3 Pillars of Cellular Energy05:08 How Mitochondria Produce Energy06:24 Oxidative Stress and Mitochondrial Damage07:39 How Mitochondrial Dysfunction Accelerates Aging08:29 Chronic Fatigue, Long COVID and Cellular Energy09:48 Your Fatigue Has an Address10:14 Join The Circle11:00 Why NAD Is Essential for Cellular Repair11:44 Why NAD Levels Decline12:13 The NAD and Inflammation Cycle13:41 What Are Senescent or “Zombie” Cells?15:22 How Zombie Cells Drive Inflammaging15:57 What Fatigue May Reveal About Your Health16:35 Cellular Energy, Focus and ADHD17:24 How to Reverse Biological Bankruptcy17:46 Sleep and Mitochondrial Repair18:15 Exercise and Mitochondrial Renewal18:41 CoQ10, Magnesium and B Vitamins19:04 Rebuilding NAD Levels19:39 How to Clear Out Zombie Cells19:59 Intermittent Fasting and Autophagy20:13 Cortisol and Mitochondrial Dysfunction21:02 Final TakeawaysProduced by https://ClipGrowth.com (Producer: Pat Gostek)

For years we've been told that if fasting is good, then fasting longer must be better.That simply isn't true.Fasting is one of the most powerful healing tools we have, but it's also a stressor. Like exercise, the benefits don't come from the stress itself. They come from how well your body recovers afterward.In this solo episode, Dr. Mindy explains how to tell whether fasting is supporting your metabolism or pushing your nervous system beyond its limits. You'll learn the five green lights that signal your body is adapting well, the five red flags that tell you it's time to pull back, and simple ways to adjust your fasting practice based on your hormones, stress levels, and stage of life.Whether you're new to fasting or you've been doing it for years, this episode will help you stop guessing and start working with your body instead of against it.In this episode you'll learn:Why fasting is a beneficial stressor, but only in the right doseThe difference between metabolic stress and chronic stressHow your nervous system influences your fasting resultsFive signs fasting is working with your bodyFive red flags that indicate your fasting routine needs to changeWhy sleep, energy, hormones, and muscle are powerful feedback systemsHow to adjust your fasting practice based on your cycle and life stageThe importance of recovery, refeeding, and metabolic flexibilityWhy fasting should always be personalizedResources MentionedDr. Mindy's BooksReset AcademyBurn Fat Like a Girl: Your Natural GLP-1 ResetNervous System Free ResourceLMNTBEAM MineralsStandard Process EZ MagFor more resources related to today's episode, visit the podcast episode page: drmindypelz.com/ep350Connect with Dr. Mindy:Join Reset AcademyWatch the episodes on YouTubeFollow Dr. Mindy on InstagramSubscribe to Dr. Mindy's newsletterDisclaimer: This podcast is intended for educational and informational purposes only and is not a substitute for professional medical advice. Always consult a qualified healthcare professional before making changes to your diet, fasting routine, or lifestyle.

Before EP Description: Learn about the Healing Power of Prolonged Fasting: HEREWhat if losing weight on a GLP-1 drug and losing weight through fasting produce the same number on the scale, but nearly opposite effects inside your cells?Host Dr. Katie Deming believes some of the most popular weight loss drugs on the market may be quietly blocking one of your body's most essential repair processes. Not because they're failing to work, but because they work in a way that keeps your body in a state it was never meant to stay in.She takes an honest, no-shame look at GLP-1 drugs like Ozempic and Wegovy and compares what's actually happening inside your body when you lose weight on them versus when you fast. The scale might show the same number. The story underneath is very different. Dr. Katie explains a repair switch your body can only flip when your stomach is genuinely empty, and why keeping it perpetually fed may keep that switch turned off for good. She connects the dots between mitochondrial health, cellular cleanup, visceral fat, muscle preservation, and metabolic flexibility in a way that's clear, honest, and direct.She's not here to shame anyone taking these medications. She gets why people reach for something that works. But she shares what happened when several of her patients who were certain they'd go right back on the drug after fasting decided they didn't want to, and why.Chapters:00:04:23 - The Food System Is Broken00:06:13 - Your Body Needs Empty Space00:08:24 - GLP-1s May Block Repair Mode00:10:41 - Weight Loss Is Not Healing00:12:26 - What Cancer Cells Feed On00:13:30 - Fasting Changes the Terrain00:17:00 - Cleaning Out Damaged Mitochondria00:18:00 - The Most Dangerous Fat00:20:35 - The Hidden Muscle Loss Problem00:22:20 - Clients Who Were on GLP-1s Before Fasting00:26:06 - Who Should Never Water Fast If you've ever wondered whether weight loss and true healing are actually the same thing, or why one of her patients gained lean mass six weeks after a 14-day water fast, this episode will change how you think about what your body actually needs.Press play and learn why the repair process your body is waiting to run may only start when you finally stop feeding it.Join Dr. Katie's 3-Day Guided Fast, for expert support, daily live calls, and a community to fast alongside: Sign-Up Follow Dr. Katie Deming on InstagramWatch on YoutubeDISCLAIMER: The Born to Heal Podcast  is intended for informational purposes only and is not a substitute for seeking professional medical advice, diagnosis, or treatment. Individual medical histories are unique; therefore, this episode should not be used to diagnose, treat, cure, or prevent any disease without consulting your healthcare provider.A thought-provoking podcast explores cancer through the lens of holistic medicine and functional medicine, discussing causes of cancer, metabolic health, and unconventional approaches like water fasting, fasting and autophagy, and detox, while weighing fasting benefits against chemo side effects and radiation side effects, sharing stories of a cancer survivor navigating chemotherapy, natural medicine, holistic healing, and even spiritual healing on the path toward cancer remission and holistic health. 

What if the disease you were told to “manage forever” wasn't your body failing you — but your cells starving, poisoned, and running out of energy? In this episode, Dr. Josh Axe reveals why your body replaces 330 billion cells every day, and why the real root of fatigue, inflammation, hormone problems, autoimmune disease, and accelerated aging may begin far deeper than your organs: at the cellular level. Uncover what's really going on in your body with advanced biomarker testing for hormones, thyroid, and metabolism— plus a 1-hour consultation with a Senior Health Advisor! →  http://mybloodwork.com Thank you to our sponsors! Sunlighten Sauna: https://get.sunlighten.com/axepodcast Manukora Manuka Honey: https://manukora.com/axe Caraway Home: carawayhome.com/drjoshaxe (Use code DRJOSHAXE) for an exclusive discount Watch The Dr. Josh Axe Show every Monday & Thursday on YouTube: https://www.youtube.com/@drjoshaxe?sub_confirmation=1

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Carnivore diet controversiesWhat is a normal oxygen saturation?  Mine has been 92-93 lately?  Is that okay?

Learn about the Healing Power of Prolonged Fasting: HEREWhat if the secret to deep healing isn't doing more, but going further?Most people assume that repeating short fasts is just as powerful as completing one long fast. Stack enough three-day fasts together and you'll eventually get the same result, right?It's a reasonable assumption, but it may be costing you the deeper healing you're working so hard to reach.Dr. Katie breaks down something many people have never been taught: short fasts and prolonged fasts are not the same healing tool. Short fasts are genuinely valuable. They can support ketosis, lower insulin, improve metabolic flexibility, and put pressure on cancer cells. Dr. Katie does a three-day fast herself every month.But she says they stop short of the second tier.That second tier begins after the early detox window, when the body moves into a much deeper fasting state. Around day eight is the threshold where the fast stops being just a metabolic tool and begins to reveal a much deeper layer of healing. Dr. Katie believes most people never reach because they keep restarting the clock.Chapters:00:04:22 - Why Short Fasts Reset the Clock00:05:21 - Detox Starts After Day Four00:06:21 - Why Long Fasts Need Supervision00:07:23 - The Danger of Refeeding Wrong00:08:21 - The Magic of Day Eight00:09:31 - The Body Targets Damaged Tissue00:10:22 - When Tumor Shrinkage Becomes Possible00:12:17 - The Mind Finally Quiets00:13:20 - Healing Crises Begin00:16:49 - Why You Can't Stack Short Fasts00:17:32 - Cancer Deserves the Full Distance00:18:52 - The Brain Tumor That Disappeared00:19:45 - Why Refeeding Matters Most00:21:00 - Fasting Opens Emotional Healing00:23:19 - What Cancer Experts Would Do00:24:45 - Physical and Emotional Healing Arrive TogetherEvery time you break a fast, your body doesn't just pause. It resets. Dr. Katie uses one simple analogy that makes this clear, and once you hear it, the difference between stacking short fasts and completing a prolonged fast becomes hard to unsee.Press play to learn why Dr. Katie believes anyone fasting for cancer needs to understand the difference between stopping early and going the full distance.Join Dr. Katie's 3-Day Guided Fast, for expert support, daily live calls, and a community to fast alongside: Sign-Up Follow Dr. Katie Deming on InstagramWatch on YoutubeDISCLAIMER: The Born to Heal Podcast  is intended for informational purposes only and is not a substitute for seeking professional medical advice, diagnosis, or treatment. Individual medical histories are unique; therefore, this episode should not be used to diagnose, treat, cure, or prevent any disease without consulting your healthcare provider.A thought-provoking podcast explores cancer through the lens of holistic medicine and functional medicine, discussing causes of cancer, metabolic health, and unconventional approaches like water fasting, fasting and autophagy, and detox, while weighing fasting benefits against chemo side effects and radiation side effects, sharing stories of a cancer survivor navigating chemotherapy, natural medicine, holistic healing, and even spiritual healing on the path toward cancer remission and holistic health. 

What happens to your body during a 5-day fast? Discover the benefits of fasting day by day, how to activate autophagy, support cellular repair and cleanup, plus fasting tips for maximum results. 0:00 Fasting day by day 1:03 mTOR fasting 1:57 Fasting day 1 2:26 Sodium while fasting 3:32 Day 2 fasting 5:10 Autophagy benefits day 3 7:47 Prolonged fasting benefits day 49:24 5 days of fasting results 10:26 Refeeding tips 11:17 Fasting contraindications

What if one of the most powerful anti-aging tools already exists within your body? This episode explores autophagy, the body's natural cellular renewal system, and how activating it can support healthy aging and longevity. Longevity expert Leslie Kenny shares her personal journey of reversing autoimmune disease and translating cutting-edge science into practical strategies. Listeners will discover how autophagy promoting spermidine, proper nutrition, and baseline lifestyle habits influence cellular repair, resilience, and biological aging.  Leslie Kenny is the founder of Oxford Healthspan, a company focused on translating longevity science into practical health solutions. She is a longevity researcher with expertise in cellular aging, autophagy, and immune system modulation. Her career includes work in finance and policy before a personal medical crisis led her to transition into health science. She specializes in spermidine research and its role in activating autophagy and influencing the hallmarks of aging. She is co-founder of the Oxford Longevity Project, a nonprofit dedicated to education in healthy aging.  Episode Timeline  00:00 – Welcome and introduction  02:00 – Reframing aging as a modifiable biological process  03:50 – Leslie Kenny's autoimmune diagnosis and turning point  10:50 – Limitations of modern healthcare and the need for prevention  14:50 – What autophagy is and why it matters for longevity  17:00 – Spermidine and its role in cellular renewal pathways  21:30 – Nutrition, mushrooms, and dietary sources of spermidine  24:30 – Hallmarks of aging and systemic cellular decline  31:00 – Development of Primadine and supplement formulation science  37:00 – Practical strategies: fasting, diet, and supplementation  41:30 – Key takeaways on influencing biological agin  Connect with Leslie Kenny  https://oxfordhealthspan.com  Instagram: @lesliesnewprime @oxfordhealthspan @oxfordlongevityproject To try Primadine Spermidine Supplement:Code: GOLY15 Link: https://www.oxfordhealthspan.com/GOLY15 Please note that Dr. Lockitch retired from medical practice and does not diagnose, prescribe for or treat any medical conditions. Before ordering any product discussed in these podcasts, consult your health care practitioner. Connect with Dr. Gillian Lockitch  at https://www.askdrgill.com/ or email: askdrgill@gmail.com  Subscribe to Growing Older Living Younger on your favorite podcast platform and leave a review to help others discover the show.   Join the Growing Older Living Younger Community at https://www.facebook.com/groups/growingolderlivingyoungercommunity  Download Guide to Nature's Colorful Antioxidants 2026 

Dr. Deb Muth 00:00:09 Hi there, how are you? Bob Miller 00:00:10 Excellent! Pedaling as fast as humanly possible, but doing okay. Dr. Deb Muth 00:00:14 Good, good. Well, I’m looking forward to our conversation today. This should be amazing. Bob Miller 00:00:20 Yeah, it should be a lot of fun. Dr. Deb Muth 00:00:22 Yeah, anything that’s off-limits for you in, our conversation? Bob Miller 00:00:28 No. Dr. Deb Muth 00:00:29 Okay, anything you want me to make sure we cover for you? Bob Miller 00:00:33 Well, I mean, is it okay if we put a little plug-in for our software? Dr. Deb Muth 00:00:35 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:38 Hey, can we… can we do a screen share? Yes, we can. Yeah, because I want to show you some maps, and… Dr. Deb Muth 00:00:43 Okay. Things like that, yeah, so… Perfect. So just let me know when you want to do screen share. Bob Miller 00:00:48 Okay. Dr. Deb Muth 00:00:49 And yeah, feel free to plug your software wherever you want to. Bob Miller 00:00:53 Okay, well, good. Let me pull up a, a slide for that, and give me one second, I just want to shut the door to my office to get the noise down. Dr. Deb Muth 00:01:01 No worries. Bob Miller 00:01:16 And, how should I refer to you? Dr. Debb? Dr. Muth, what do you like? Dr. Deb Muth 00:01:18 Dr. Deb is great, or Deb, either way, I’m pretty informal, so… Bob Miller 00:01:22 Yeah, and… Bob is fine for me. Okay. Yeah. Yeah, there you go. Why people feel like they need this, son. Special name, it’s like, seriously. Dr. Deb Muth 00:01:33 Right? I agree. Bob Miller 00:01:35 When I work with my clients, it’s like, Dr. Millison, just, just bop, just, just bop. Dr. Deb Muth 00:01:41 Yep, that’s how I am, too. Just call me Deb, it’s good. Dr. Deb Muth 00:01:44 They feel a little awkward with that, you know? They’re not used to that, but… Bob Miller 00:01:48 Alright. And you’re a naturopath, medical doctor. Dr. Deb Muth 00:01:52 A nastropathic doctor and a nurse practitioner. Oh, nice. Yeah, so I got the best of both worlds, right? Bob Miller 00:01:58 Yeah, damn. Okay. Alright, so here we go… There we go. Alright, so I got that ready, and then I will do a, I will do a screen share. I think you’re gonna really, appreciate what we’ve come up with. We’ve come up with the concept of, Cellular CPR. Dr. Deb Muth 00:02:23 Oh, nice! Bob Miller 00:02:24 And that is, construct the cell membrane, Protect the cell membrane. And restore it if it’s damaged. Dr. Deb Muth 00:02:32 Love that. Bob Miller 00:02:34 I love that. Yeah, so that’s what we’re focusing on, and then how, You know, we want to get to the point that, you know, most people think of genetics, they think of, like, 23andMe or Ancestry. Dr. Deb Muth 00:02:44 Yeah. Bob Miller 00:02:45 And then you have the professional geneticists who are looking at, you know, odd things that could create a disease. We’re looking at functional genomics. Dr. Deb Muth 00:02:54 Which is so much better. Bob Miller 00:02:56 Yeah. Are you familiar with what we do here, or… Dr. Deb Muth 00:02:58 A little bit, a little bit. So, it’ll be new to me, too, so I’m excited. Bob Miller 00:03:03 And how much time do we have? Dr. Deb Muth 00:03:04 We have an hour, give or take a little bit on either side. Do you have a hard stop anywhere? Bob Miller 00:03:10 No, no, I put a, I moved my clients around, and I don’t have anybody till, 3.30, so we’re good. Okay. Dr. Deb Muth 00:03:16 Perfect. Alright. Bob Miller 00:03:18 It’s like we’re getting started early as well, so… Dr. Deb Muth 00:03:19 Yeah, we’re getting started a little bit early, so that’s good. Bob Miller 00:03:22 Yeah, I just got my office cleaned up, so… Dr. Deb Muth 00:03:23 Okay, good. All right, are you all set to get started? Bob Miller 00:03:28 I’m good to go, my friend. Dr. Deb Muth 00:03:29 I’m gonna just record a little intro and a little bit of a, hook for people, and then we’ll get started. I’ll ask you to kind of tell us a little bit about yourself, and then we’ll just take this conversation wherever it’s supposed to go. Bob Miller 00:03:39 Okay, you got it. Dr. Deb Muth 00:03:40 Alright, sounds good. So what if the reason you’re not healing isn’t your diet, your supplements, or your labs, but it’s actually your genes? Dr. Bob Miller is uncovering how genetic variants, when combined with modern toxins, explain why some of us stay sick no matter what we try. Today, we’re talking genetic pathways, detox blocks, and the new science every wellness warrior needs to know. Welcome back to Let’s Talk Wellness Now, the show where we uncover the root causes of chronic illness, exploring cutting-edge regenerative medicine, and empower you to heal from the inside out. I’m Dr. Deb, your medical detective, and today, our guest, Dr. Bob Miller, is a true pioneer in functional genomics. He’s a board-certified traditional naturopath and the founder of Neutrogenetic Research Institute. And he’s the leading groundbreaking research on how genetic variants influence chronic illness, inflammation, and detoxification. His work has been recognized on international stages, uncovering links between genetic expression and conditions like Lyme disease, mast cell activation, or MCAS, and mitochondrial dysfunction. I’m so excited to talk to Dr. Bob today. He is gonna reveal some things that even I don’t know about, so I’m excited to learn alongside of you guys. So… Dr. Bob, let’s get started. Tell us a little bit about yourself, and kind of how you got on this journey. Bob Miller 00:05:04 Well, that’s, that’s interesting. I was sort of like a mid-career coming to the natural health field, because in my early 30s, I found myself with a severe case of ulcerative colitis. Bob Miller 00:05:15 And I was in the hospital for 21 days. probably within hours of death, pleading to death. And they told me I’ve got one option, and that is cut out the colon and wear a bag. Didn’t sound like a lot of fun. Dr. Deb Muth 00:05:27 Not an option I would want. Bob Miller 00:05:29 So, you know, the medical folks wasn’t real happy with me, but I said, yeah, I’d like to explore some alternative things.Never thinking that I’d get into this field, and then I just, you know, worked with some herbalists and things that I found absolutely fascinating. So, that’s how I got into this around 30 years ago. And, haven’t looked back since, and just having a… having a blast as we now move into how our genetics impacts things. So, that’s what we’re gonna… that’s what we’re gonna talk about today. Dr. Deb Muth 00:05:58 I’m excited to talk about this genetic thing. When you started over 30 years ago, what kind of patience and problems first inspired you to dig deeper into that root cause healing and kind of get into the genetic piece of it? Bob Miller 00:06:10 Sure. Well, you know, as a… now, I’m in a part of the country called Lancaster County, Pennsylvania, where there’s a lot of Amish and Mennonite, and they gravitate towards these things.So, this is their first thing to do, and that doesn’t work, then they’ll go other routes. So, you know, back then, we just saw typical, you know, a little tired, constipation. You know, a little bit of fatigue, arthritis, those kind of things. But things have changed dramatically over the years, as people are now getting more chronically sick. You know, it’s worse than it’s ever been. And what we’re finding is the, the culprits Primarily is mold exposure and Lyme disease. When people get those two together, they’re just… it’s an inflammatory cascade that nobody can seem to unravel. So that’s where we spend a lot of our time. And we’re also spending a lot of time looking at mental health, like ADD, ADHD. And, we give… this year I’ll be speaking at three autism conferences. And we can dig into that a little bit as to why we think we’re seeing such a dramatic increase. And aside from autism, that used to be 1 out of 1,000, now it’s 1 out of 33, or 23. You know, we’re also seeing dramatic increases in ADD, ADHD. People are stressed out. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. Dr. Deb Muth 00:07:37 This should be a fun visit. We can cover lots of topics. I am so excited. So, you founded Nutri Genetic Research Institute in 2015. What did you hope to accomplish, and what kind of surprised you in your findings so far about that? Bob Miller 00:07:51 Well, you know, let’s back up at what, you know, genetics is used for. Everybody’s familiar with 23andMe and Ancestry that, you know, tells you where your ancestors came from. Then you have your professional geneticists. I mean, these are people with a degree in genetics. And they’ll look for, you know, very odd sort of things that are prone to relate to a disease. So there are disease-related genetics. Well, in functional, we don’t look at either of those. We look at For example, how you’re breaking down your fats and utilizing them. How you’re recycling your glutathione. How you might be handling your iron. And none of those are disease-causing on their own.And none of those are disease-causing on their own. But when they pile up on you, and then combine that with environmental factors, that’s when things start to go south on us. So, that’s what we’re doing, we’re looking at patterns. And our first foray into this was, we did studies on Lyme disease. And our first foray into this was, we did studies on Lyme disease. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. Others have a little more struggle, and then others are struggling terribly for years. So there’s an old adage of genetics loads the gun, environment pulls the trigger. Dr. Deb Muth 00:09:14 Yeah, that is so true, and I think when we’re talking about Lyme and mold and things like that, we forget sometimes that our genetics can predispose us to be more sensitive to those things, and if we have genetic pathways where we don’t clear things properly, it’s harder for us to get them out of the body. And then you add on that whole rain barrel effect that we’ve always used as a functional medicine term, right? If the barrel’s half full, you’re okay. If it’s full, and now it’s spilling over, it’s a bigger problem. Have you guys found, too, that some of these environmental things actually are changing the genetics of people, or how they’re processing their own genetics? Bob Miller 00:09:53 Well, let’s go back to, Genetics 101. But we’ll go back a little bit further. So, what an interesting mechanism, what a miracle the body is. Bob Miller 00:10:03 Fats, carbohydrates, proteins, drink water, breathe air, expose the sunlight, and somehow everything gets made. I mean, when you just step back and think about that, it’s like, It’s pretty darn amazing. Dr. Deb Muth 00:10:15 I always tell women, you know, the fact that we get pregnant and we have healthy pregnancies and births is a miracle, because if we had to try to control that, that wouldn’t work so well. Bob Miller 00:10:25 Right. Well, that’s another miracle. These microscopic sperm and egg, human being, 9 months later, it’s like. But even inside of us. We are making our hair, our skin, our nails, our blood vessels, our ATP, our energy, it’s all being created. Well, that gets created by enzymes. So, enzymes take one substance, combine it with something else, and make something new. Then another enzyme comes along and does the same thing. Your DNA is the instructions on how to make the enzymes. So, when we are conceived. If it’s a, if it’s a female, of course, it’s the XX, the two chromosomes. You know, we’ve… everybody’s seen those… the genetics that… Listed pair. So, if it’s a female, the father donated the X enzyme. And the mother has no choice but to give the eggs, so that’s female. If the father donates the Y, you have a male that’s in chromosome number 1. Then 2 through 23 is the rest of the instructions on how to make enzymes. So, what can happen? We can get what are called SNPs, single nucleotide polymorphisms. And SNPs just mean that the instructions to make the enzyme’s not quite as good. So, if one parent gives a SNP on the making of an enzyme, The enzyme’s fine. It works. But, general rule of thumb, It may only work at 70-80% of efficiency. Now, a good analogy is think of an 8-cylinder and a 6-cylinder car. If parents give you good information, that’s like having an 8-cylinder car. If one parent gives you that snip, it’s like having a 6-cylinder car. Now, is a 6-cylinder car a fine car? Sure. It’ll get you from point A to point B, but it’s just going to have the power of an 8-cylinder. Then if both parents give you a SNP on the same enzyme, it may be 30-40%, and that’s like having a 4-cylinder car. Sits in the driveway, looks the same, puts gas in it, everything. But if you’ve got a 4-cylinder car. Probably not a good idea to go cross-country pulling a trailer behind you up and down mountains. Dr. Deb Muth 00:12:29 This is true. Bob Miller 00:12:32 So… We can get an 8-cylinder, 6-cylinder, or 4-cylinder enzyme. Now, if it’s not under a lot of stress, if that 4-cylinder car is just taking you to the bank and the grocery store. It’s just as good as an 8-cylinder car. But if you gotta pull that trailer, and there’s a lot of stress on it, being mountains, it’s gonna struggle. Now, there’s one other little caveat to this, and that is some genetic mutations are gain-of-function. They actually work faster. Now, we have enzymes that do all kinds of things. We have enzymes that make and recycle our antioxidants, but we also have enzymes that make inflammation. No, that’s a good thing, because if we get a virus or bacteria, if you didn’t make inflammation to kill it, well, we’d all die of infection. So, you know, we tend to think of free radicals as bad, antioxidants as good. They both play an important role. But interestingly, some of the major enzymes that make inflammation, they can be overactive. They can be turbocharged. And when they’re stimulated by environmental toxins, they overreact. Bob Miller 00:13:40 And therein lies the problem. When they overreact, we have a problem. Bob Miller 00:13:46 So, if we have genes that overreact when stimulated. And then the enzymes that take care of inflammation are underactive. Then you’re gonna be more inflamed. You know, the majority of people that, you know, come for functional medicine Or naturopathic help, or… Inflammation that they can’t seem to get under control. Dr. Deb Muth 00:14:06 Right. Bob Miller 00:14:07 And we will be, you know, during this hour, we’re going to look at some of the pathways that make that happen. So, what we can do then, we can’t change our genetics. When you’re conceived, that’s the hand you’re dealt. When your life would be over, if someone would take some tissue and measure, it’d be exactly the same as conception. Does it change. Bob Miller 00:14:28 The enzyme’s ability to do its job may be compromised. Because remember I said there’s a, the enzyme takes a cofactor. So an enzyme takes substance A, cofactor, make substance B. Well, if that cofactor’s not there, the enzyme’s not going to work either. So, you could have an 8-cylinder car, and if there’s no gas in it, it’s not going anywhere. So… It’s the strength of the enzyme, it’s the cofactor to do the A to B conversion. And that’s what we’re going to get into. So, many people say, well, where did these SNPs come from? Nobody knows for sure. Sometimes they’re what’s just called de novo, when the sperm and egg go together, the instructions get mixed up a little bit. We do believe a lot of it came from a long time ago, when we were almost wiped out by sexually transmitted diseases. And those STDs were altering the genes when the conception, in other words, when the sperm went into the egg, the STDs were interfering. And causing the problem, so… I often joke, if you want to blame somebody. Blame your great-great-great-great-great-great-great-grandparents for, being a bit promiscuous, so… Dr. Deb Muth 00:15:31 Yeah, for being… having a little too much fun, right? Bob Miller 00:15:35 So, we don’t know for sure, but, you know, there are some that, But most of the SNPs that we get inherit from our parents. So, if you look at a child. And you look at the SNPs. 99.9% of the time, it came from one of the parents. Dr. Deb Muth 00:15:50 In identical twins, do they have the exact same identical makeup? Bob Miller 00:15:54 Yep, Dr. Deb Muth 00:15:56 But not in fraternal twins, correct? Bob Miller 00:15:59 No, no, those could be different, Jeff. Dr. Deb Muth 00:16:00 It could be different because they have different sacs, they’re not sharing that same genetic makeup. Bob Miller 00:16:04 Yeah, so keep in mind, both your mother and your father have, you know, the two And so you get one from one parent, one from another. Dr. Deb Muth 00:16:13 So… Bob Miller 00:16:14 Interesting situation. I had, 3, 3 boys. And, we were looking at an enzyme related to breaking down oxalates. Now, the mother and father each had one SNP, and that’s called heterozygous. Three boys, and they all come together, they’re Amish boys, they’re a lot of fun. And I looked at their genomes, and the one boy didn’t have any SNPs at all. And one had won. And the other one had two. Dr. Deb Muth 00:16:41 Interesting. Bob Miller 00:16:42 So, we don’t quite know how these things get handed off, but with the parents each having one, you could have a child with none, one, or two. So, the one, his ability to break down oxalates, which is fine. The other one was slightly impaired, and the other one was dramatically impaired. So, you can have 3 children, and it all depends what the parents have. Now, if a parent has a homozygous, or 2 copies. And the other parent has nothing. Every child will have one. Okay. If both parents are homozygous, that they both have two, Every child will have two. Dr. Deb Muth 00:17:19 too. Bob Miller 00:17:20 Yes, so that’s the way it works, but, you know, but it’s somewhat rare that both parents are homozygous on an enzyme, but it can happen. Dr. Deb Muth 00:17:27 Do we think that infections today, like Lyme disease or mold exposure, things like that, if the parent, the woman, primarily, I’m thinking, is pregnant, and she actively has these infections. Can those infections affect the genetics, kind of like a past sexual transmission did where we thought back in the day? Bob Miller 00:17:47 Yeah, I… I mean, I’m not that much of a geneticist to answer that for sure, but my thought would be no, that at conception, the pattern’s made. Dr. Deb Muth 00:17:55 Okay. And then that’s… that’s the hand you’re dealt. Bob Miller 00:17:58 Yeah. So, I tell people we have good news and bad news. The good news is we can compensate for the weakness. The bad news is we can compensate for the weakness. Dr. Deb Muth 00:18:09 That is so very true. Bob Miller 00:18:11 Yeah, we can’t, because I often get asked, so we’ll do some things now, and we’ll check my genes again, and they’ll be better. It’s like, nope. Dr. Deb Muth 00:18:18 Oh, – – Bob Miller 00:18:19 You gotta play the hands you’re dealt, so… Dr. Deb Muth 00:18:21 That’s right. Bob Miller 00:18:22 You can test your genetics… if you’re looking at the same enzyme, you can test it every year. It’s not gonna change. It’s like the blueprint. Dr. Deb Muth 00:18:30 It’s good and bad, right? It’s the one test you only have to do once in your lifetime. Bob Miller 00:18:34 No, unless, you know, like, our. Dr. Deb Muth 00:18:36 All the time. Bob Miller 00:18:37 Yeah, now our test looks at, called the Functional Genomic Analysis Test of your genomic Resource. We look at 220,000 steps. Dr. Deb Muth 00:18:46 Wow, that’s a lot. Bob Miller 00:18:47 That’s not all of them. Dr. Deb Muth 00:18:49 Right. Bob Miller 00:18:50 So, maybe in the next year, we’re gonna come out with our third version of the chip. And then, if someone wants to get those new things that weren’t on it, they’d have to repeat. But whatever we measured is gonna stay the same. Dr. Deb Muth 00:19:03 That’s a lot of SNPs to look at. Bob Miller 00:19:05 Keeps us busy. Dr. Deb Muth 00:19:06 But there’s still, but there’s still SNPs that we. Bob Miller 00:19:09 That we’d like to have that we don’t have, so… Bob Miller 00:19:11 We started out with version 1 on our genetic test, then we worked with version 2, and we’re already compiling a list of what version 3 would look like. So if somebody has our version 2, And we’re saying, you know what, it’d be nice if we could see these, well, then you’d repeat, but it won’t change what you already know, so… Dr. Deb Muth 00:19:29 Got it, got it. So, when you started out, and you started looking at the research of Lyme disease and chronic infections, which detox pathways are most important for people who struggle with those conditions? Bob Miller 00:19:43 Okay. You know what might make sense as we do a screen share, and I’ll actually show you the pathway. Does that make sense? Bob Miller 00:19:48 Alright, so… let’s see if I… let me just press the share… Dr. Deb Muth 00:19:52 Yep, you should just be able to press share. Bob Miller 00:19:54 And… number 2. Okay. Are we seeing the screen there? Bob Miller 00:20:01 Okay. Dr. Deb Muth 00:20:02 So, this is a map that we made. Bob Miller 00:20:05 And by the way, this is not… All-inclusive of all the things we look at, but we believe this is a core issue. So, where we’re going to start here, there’s something called the microglia. And the microglia are glial cells. They’re in the brain and the central nervous system. And they’re very interesting little creatures, because most of the time, and this is just a drawing of what they sort of look like. Most of the time, they’re in what’s called the M2 anti-inflammatory mood. What that means, these little guys pick up dirt, debris, Recycle them. Turns on an enzyme called interleukin-10 that’s anti-inflammatory. And just kind of does general housekeeping. And just kind of does general housekeeping. However, when a trigger comes along. However, when a trigger comes along. They… it’s the same glial cell, but it moves over to a very pro-inflammatory enzyme. A pro-inflammatory glial cell. And it triggers these 3 enzymes, Actually, these four. That are pro-inflammatory. Tumor necrosis vector alpha, Interleukin-6. NF Kappa B, Inos. Now, these create inflammation. So you might think, well, why is that good? Well, if you have some foreign invader, virus, bacteria coming in, parasite. If you didn’t have these guys coming to the rescue, you would just die of infection. So, these guys are your friend unless they’re your worst enemy. Because TNFA, and we’ll show you when we actually do a demo account, TNFA can be overactive. So, in other words, it over-responds. Interleukin-6 can be overactive. And if Kappa-B can be overactive. The INOS, and I’ll explain each of these as we go through a demo, can be overactive. Now, what that means is, you’re very good at killing virus and bacteria. But this is where autoimmune disease comes in, and just inflammatory conditions. Now, this is just speculation, but we think what happened is, as you know. Thousands of years ago, we didn’t have refrigeration, we didn’t have sewer, we didn’t have pure water, and we didn’t have antibiotics. So, if you made it to 40, you were an old-timer, because everybody was dying of infection. So, what we believe happened is, by what’s called natural selection, Having these overactive. A thousand years ago was to your advantage. Dr. Deb Muth 00:22:31 Hmm. Bob Miller 00:22:32 But now… We have pure water, we have refrigeration, we have sewers, we have antibiotics. But now we have environmental factors that are stimulating them. Now it’s to our disadvantage. And we’ll talk about that a little bit as it relates to the hemochromatosis genes and maybe the G6PD. Dr. Deb Muth 00:22:48 Yep. Bob Miller 00:22:49 Now, why are we becoming so inflamed? Let’s look at the triggers. Now, one of my, favorite expressions is. I was born all the way back in 1954. Dr. Deb Muth 00:23:01 And it was a different world back then. Bob Miller 00:23:05 These are some of the triggers. And we’ll get into these, but right now, high fructose corn syrup, And the high-fat diet. High fructose corn syrup only came about in 1968. So now we’re being exposed to high fructose corn syrup. Then… we didn’t have these, these viruses like COVID. Dr. Deb Muth 00:23:26 Yeah. Bob Miller 00:23:27 Now, there’s now pretty strong evidence that COVID Was actually, you know, made as a gain of function. It’s debated, and I’m not taking an opinion on it, but there’s some people who believe Lyme disease was also a part of experimentation. Dr. Deb Muth 00:23:40 Go. Bob Miller 00:23:41 Then we have molds, and it appears as though mold is getting stronger. you know, 20 years ago, when I was seeing folks, mold wasn’t on the radar. I would say 7 out of the 10 folks we speak to today have mold problems. Yeah, 20 years ago, we talked more about mold allergy being an issue versus mold toxicity being an issue. Right. So… I know some folks are, you know, speculating what’s happening, but one of the theories out there is that EMF is strengthening mold. I don’t know if you ever heard that theory, and I don’t… Dr. Deb Muth 00:24:13 I have. Bob Miller 00:24:14 I’m not claiming it’s true, but it’s an interesting theory. Then even, you know, your black mold from water-damaged buildings. Then our air pollution is getting worse. We’re getting more toxic metals. Dr. Deb Muth 00:24:26 You know, if we have a… Bob Miller 00:24:27 You know, we’re gonna look back someday and say, what were we thinking, smearing aluminum into our armpits? The, what were we doing putting mercury in our teeth? Then, you know, glyphosate. When I was a kid, there was no glyphosate. So, all of these herbicides and pesticides. Polychlorinated biphenols, And then EMF. So, we love our cell phones, you know, and I think unless you, or in the middle of the desert, or down in a cave, you’re being exposed to EMF somewhere. So, you know, we have our cell phones with us, we have, We have Wi-Fi, the towers are everywhere. And we don’t know long-term, but we may find that this can… this creates some inflammation. And I don’t know if you get any folks, but do you have any folks that have… are they EMF sensitive? Dr. Deb Muth 00:25:16 Oh yeah, we have a whole bunch of them. Bob Miller 00:25:18 Yeah, and then if you have any TBIs, So, plenty of things here. that will stimulate into the microglia, M1. Now, you could say, well. We’re all pretty much exposed to the same thing. Why do some people get hit harder than others? So here’s where we’re gonna start. There’s an enzyme called Nrf2 and RF2. And Nrf2 is the enzyme that senses when there’s inflammation. And turns on hundreds of anti-inflammatory enzymes. We’ll show when we do the demo, you can have genetic weakness on NERF2. And NERF2 inhibits and slows down microglia M1. supports M2. Now, if it’s not complicated enough, there’s an enzyme called KEEP1. And KEEP1 inhibits NRF2. And you can actually have gain of function on keep 1, that makes Keap 1 stronger. So… A lot of the people who land on my doorstep So… A lot of the people who land on my doorstep Both parents gave a mutation on KEEP1, making it overactive. Both parents gave a mutation on KEEP1, making it overactive. Dr. Deb Muth 00:26:31 Hmm. Dr. Deb Muth 00:26:31 Hmm. Bob Miller 00:26:32 Suppressing Nrf2, nerve 2 might be weak. So, nobody’s putting the brakes on, M1. And by the same token, Nerve 2 supports M2. Then there’s a process called mTOR and autophagy. mTOR stands for mammalian tard of rapamycin, the growth of new cells. And then autophagy, taking our dead cells and recycling them. We need a balance between the two of them. If we didn’t have mTOR, the sperm and the egg would never become the baby, the baby would never become the adult, we wouldn’t make new cells. But our cells are constantly, you know, the old cells dying off. Autophagy is where we take that debris from the cell and recycle it, just like a farmer Plows the crop under at the end of the year. The dead plant then becomes the fuel for the spring, your dead cell becomes the fuel for the spring, and that’s autophagy. So we’re gonna look back someday and say, what were we thinking? We give our animals growth hormones so they get fatter faster. Oh my. So, we consume those animals, and inventory runs faster. Now, for anybody who’s, You know, maybe above 40, 45 years old. Think back when you were 12, and what did girls look like? They were primarily flat-chested little girls. Now they look like 16-year-olds. Because environmentally, we’re jacking up mTOR. So, mTOR stimulates microglia M1, suppresses microglia M2. Probably 80% of the folks we visit with. This is the part of the problem. NRF2 is weak. mTOR is strong. Environmental factors come along. And this guy gets carried away. He doesn’t do that burst and move back. Stays here. We’re calling that How environmental factors create a locked-in, pro-inflammatory. and neurotoxic phenotype. In other words, once it starts, it just keeps… Feeding upon itself. Alright, so what happens now when microglia is overactive. it triggers these 3 enzymes, TNFA, N of kappa B, And interleukin-6. Each one of these can have genetics that make them run stronger. Then it stimulates an enzyme called NLRP3, Which makes what are called inflammasomes. Now, guess what inflammasomes can be? Your best friend or your worst enemy? Because they will, if you’ve got, again, a virus or bacteria, or possibly even some bad cells in the body. They will zap them. Well, that’s good. Unless it’s overactive. Unless it’s overactive. And then what it does, through interleukin-1 beta, makes excess glutamate. And then what it does, through interleukin-1 beta, makes excess glutamate. Anxiety, gut inflammation, OCD, ADD, autism. And, you know, glutamate, we’ll talk about that a little bit, but glutamate makes you intelligent, highly motivated go-getter. but can also be excitatory. And then, look what it does. Let’s see, do I have the drawing tool here? Yes, I do. Okay. So, it comes down through here, Makes the glutamate. Comes back up through here. through the ADORA 2A enzyme, Then we’ve got a feedback loop that feeds upon itself. Then, through interleukin-18, we make histamine. and mast cells. And then through histamine receptor site number 1, we come back and spin it. And now you’ve just got this spinning feedback loop. So, the glutamate will make you anxious, the histamine will give you allergies and make you anxious. And you’re allergic to everything, and you’re feeling horrible. Now, it doesn’t end there, Dr. Dad. It then goes on to make something called gast dermins that creates pyroptosis, where it actually starts punching a hole in the cell membrane. And you’re only going to be as healthy as your cells are. Just a little background. You know, we’re made up of trillions of cells, and each one of them has what’s called a lipid bilayer, made from lipids, which comes from fats. And you’re only going to be as healthy as those membranes are. So that’s why we coined an interesting phrase. Cellular CPR. Construct the cell. Protect the cell. And restore the cell membrane. And we believe that’s going to be revolutionary in the functional medicine world. So… It’s not hard to figure out that if you start punching holes in the cell membrane, that’s not a good thing, okay? Bob Miller 00:31:22 Now… There’s an interesting molecule called NAD. Thicotide adenoside dinucleotide. And anybody who’s in the, you know, listening to the health podcasts and things, they’re… They’re, they’re learning about NAD. And I’m going to show you a chart later, all the good things that NAD does, but For the most part, it helps what’s called sirtuins. And sirtuins are quite interesting. If anybody’s looking at longevity. The sirtuins is where they’re looking at.Because sirtuins turn on good things. Turn off bad things. And I’ll show some charts on that later. So for right here, this sirtuin uses NAD, to slow down NF-kappa-B. CERT 2 uses NAD to slow down an ORP3. So, if we’ve got genetic weakness on these, or we don’t have enough NAD, We don’t hold this pathway back. Make sense? Dr. Deb Muth 00:32:24 Yeah, makes perfect sense. Bob Miller 00:32:25 Now, I’ll show this a little bit later. So, people are like, oh, well, I’m gonna start taking some NAD. Dr. Deb Muth 00:32:31 Right. Bob Miller 00:32:32 And there’s functional doctors who give NAD intravenous. It was just this morning, I was talking to a woman who said, Oh my gosh. I went and got intravenous NAD, and it took me a month to recover from that. Dr. Deb Muth 00:32:45 Hmm. Bob Miller 00:32:46 what happens is, and I’ll show this in a little more detail, there’s an enzyme called CD38, that’s stimulated by NF-kappa-B. And it takes NAD, To make intracellular calcium. that stimulates NLRP3 and actually makes things worse. So, if we have this guy upregulated, and I’ll show a chart what does that. taking NAD will make you worse. Again, when I go into the software, I’ll show you that whole pathway, so… I would encourage people, you know, just don’t go out and start taking massive amounts of NAD, you know, stick your toe in the water, see how you do. Because everything you’ve heard about, how good it is, is true, unless this guy says, oh, thank you very much, let me make more inflammation. Now, this might be part of our innate immune system, that if we have some pathogen that’s gonna kill us. By golly, we want that to happen. But if this is happening by environmental factors, Then it’s detrimental. So the immune system that protected us a thousand years ago now might be turning on us because of the environmental factors that we showed earlier. All right. Then there’s an enzyme called PARP that’s NAD-dependent, and that actually repairs strain breaks in your DNA. Now, the next thing that happens… is there’s an enzyme called NADPH oxidase that gets stimulated. and something called INOS. Now, I’m sure most people know about nitric oxide. It’s a gas that dilates your blood vessels. That’s why sometimes they’ll even give people drugs, nitroglycerin, to boost their nitric oxide. That’s why people are doing beetroots and other things to boost their nitric oxide. But there’s an OS3 enzyme that makes the nitric oxide that’s good for blood flow. But there’s an INOS That makes nitric oxide to kill pathogens. probably might be the third or fourth time I’ve said this. That’s a good thing, unless it isn’t. So, if it’s killing some pathogen, great. It was just misfiring. it combines… With superoxide that’s made by this enzyme, and makes something called peroxynitrite, which is one nasty free radical that chews you up and spits you out. So, the NOx enzyme, NADPH oxidase, uses NADPH, To make this free radical called superoxide. If we have time, we’ll get into it. NADPH is what your body needs to recycle your antioxidants.So, I coined the phrase, the NADPH steel. Where the NOX enzyme takes this very important NADPH, And rather than being useful, makes superoxide. Now, again, is that fine if you’ve got some bacteria to kill? Of course. But if it’s just chronically running, it’s just making all this chronic inflammation. Then it makes something called hydrogen peroxide. And we need to clear hydrogen peroxide by 3 enzymes, catalase, thyroid reduction. And glutathione peroxidase. If we have genetic issues on here, or we don’t have the cofactors. There’s something called the Fenton reaction, discovered in 1895 by Dr. Fenton. Where hydrogen peroxide combines with iron to make what are called hydroxyl radicals. And guess what they do? They create lipid peroxides, That damages your cell membranes. Now, again, the body’s pretty darn amazing. We have glutathione, And here’s where your body’s taking glutathione and recycling it. But look who’s needed to recycle it. NADPH. So, if this guy up here is chewing it up, We don’t recycle our glutathione. And then an enzyme called glufon peroxidase 4, Takes this damaged lipid and repairs it. So, here we’ve got this protecting, we want to protect it by not having this happen. But then we also need this guy to do the restoration. So, there’s a lot that can go wrong in here, Dr. Deb. Dr. Deb Muth 00:37:07 There’s a lot that could go wrong. And I can imagine some of my listeners are thinking that lipid peroxidase, is that the same thing as what they’re thinking of when we talk about lipids and cholesterol? Is that the same process that’s happening there? Bob Miller 00:37:22 Well, no, no, the lipids can be used to make cholesterol, but here we’re talking about where they’re going to build the cell membrane. And they’re being… and they’re being, destroyed. If anybody would like to see a visual representation of this, just go on YouTube. And type in, ferrooptosis Animation. cool little video, it’s about 3 minutes long, and it shows the lipids coming over, being oxidized, and now GPX4 fixes them, so… YouTube, Pharaoptosis Animation, cute little video. It’s just that really… Shows vividly what we’re… what we’re talking about here. Now, this is… Dr. Deb Muth 00:37:59 And so this is very common, too. Like, a lot of people do hydrogen peroxide IVs. Dr. Deb Muth 00:38:04 And so, if somebody doesn’t know their genetics, they could have a problem with doing those, just like they could doing the NADHIVs, correct? Bob Miller 00:38:13 Sure, yeah, yeah, yeah. So, I’ve talked to so many, you know, of course, the hydrogen peroxide kills pathogens. I mean, that’s what it does. So… but I’ve spoken to so many people that said. I had one client that said they’ve never been the same after having one hydrogen peroxide infusion. Dr. Deb Muth 00:38:30 Interesting. Bob Miller 00:38:31 Yeah. So… it can be… I see why people use it, because it. Bob Miller 00:38:36 pathogens, But on the other hand. And now’s a good time to speak about… I don’t have it on here, but there’s a, there’s an enzyme called the HFE gene. And that is what causes you to absorb iron. And there’s mutations in it that cause something called hemochromatosis. Were you overabsorb iron? Now, true hemochromatosis is when both parents give you a mutation. But there’s now growing evidence even a heterozygous can cause a little bit more iron absorption, not to the human chromatosis point, but overabsorption. So, if you overabsorb iron, And you have too much hydrogen peroxide that’s not cleared, All kinds of inflammation. Now, what’s happened is sometimes this inflammation Will damage the red blood cells. And some well-meaning doctor says, oh, you need some iron. And they take iron and it makes it worse. So, can’t tell you how many people I’ve said, you’ve got the overabsorption of iron, and they say, well, that can’t be right, because I’m low in iron. Well, that could be because it’s being chewed up here. Dr. Deb Muth 00:39:40 Sure. GPX1 and TXN turn it into, to water. The, catalase turns it into water and oxygen. Dr. Deb Muth 00:39:58 Now, I see a lot of my clients who have mutations or SNPs on that GPX gene, on that glutathione gene. And they really struggle to clear a lot of their toxins. Bob Miller 00:40:12 Sure. Dr. Deb Muth 00:40:14 Yeah, absolutely. Well, GPX4. Bob Miller 00:40:18 is what, repairs, but you can see GPX1 Is what uses glutathione. To turn hydrogen peroxide. So, but it all depends upon having enough glutathione. Dr. Deb Muth 00:40:30 Yeah. Bob Miller 00:40:31 Well, guess who controls making a glutathione? Dr. Deb Muth 00:40:34 Nerf 2. Bob Miller 00:40:37 So, if you have a keep one weakness, or strength to two… I’m sorry, keep one is too strong. Nrf2 is too weak. You don’t make glutathione. So, when a lot of people do that, it’s like, well, I’m gonna take glutathione. Dr. Deb Muth 00:40:51 Right. Bob Miller 00:40:52 And some do great, and some do poorly. You know, because… and I’ll show this on one of the other charts. You can see here that the, The glutathione has to be recycled. And if we don’t recycle it, it actually turns into superoxide free radical. So… NADPH are the cofactors, For taking the oxidi… here’s oxidized glutathione, here’s reduced. So, this is a good glutathione. After it does its job, you can see it becomes oxidized.We need to recycle it. Well, if we have weakness on the enzyme that does that, or a weakness in Nrf2, or not enough NADPH. The oxidized glutathione never gets recycled. So, I’ve talked to a lot of people who said, oh, glutathione made me so sick, and say, well. Dr. Deb Muth 00:41:43 Yeah. Bob Miller 00:41:44 You need it, but you need to recycle it. Dr. Deb Muth 00:41:46 Can you speak for just a brief moment, too, about MTHFR? That is a very popular gene, it’s all over social media as the major gene, but can you speak to a little bit about that, and how that fits into this whole process of things? Because it is just such a small piece. Dr. Deb Muth 00:42:04 understanding genetics. Bob Miller 00:42:06 Yeah, to be honest, it drives me nuts. Dr. Deb Muth 00:42:08 Me too. Bob Miller 00:42:11 Alright, so… You know, there are people on social media I won’t say what I think, I’ll be kind. But… But the, And, you know, they might mean well. But they talk about, if you have MTHFR and COMT and PEMT, that’s… oh my goodness, that’s horrible, and we’ll fix that for you, and you’ll be fine. Bob Miller 00:42:36 it just irritates me to no end. And it really could get anybody who’s doing this legitimately in trouble. I mean, I’m afraid someday, you know, there might be some cracking down on this kind of nonsense. Now, to answer your question about MTHFR. Dr. Deb Muth 00:42:51 I mean, it really is, but I’ll tell you what, why don’t we hold that thought until I go to another map and I can actually… Okay. Bob Miller 00:42:56 But the real… the cliff notes is the MTHFR puts a methyl group on your folate, which is needed, but it has gotten way, way, way too much attention. And people learn they have MTHFR, and they start taking a multivitamin with methylfolate, then they take a B vitamin with methylfolate. Dr. Deb Muth 00:43:13 And they’re pushing it too hard. Bob Miller 00:43:15 Yeah. So I can’t tell you how many people I’ve helped by saying, stop it. Dr. Deb Muth 00:43:20 Yeah, take less of it. Bob Miller 00:43:21 Take less of it, yeah. So, yeah. Yeah, there’s a… If somebody, say, ranked the enzymes at their level of importance, MTHFR might be 40 or 50 on a scale of 100, you know. Keep one Nerf two. big deals. Dr. Deb Muth 00:43:40 deals. Bob Miller 00:43:41 NQO1 that I didn’t even talk about yet, NQO1, takes your, NA… your NAD goes into NADH, To make electrons for the electron transport chain. you need NQ01 to bring that back. If that’s not working, and I’ll show you on the NAD map how disastrous that can be. Now, the next piece is here, and I think You know, if you talk to any school teachers and say, if you’ve taught for more than 10 years, how are the kids today? Every one of them says, more ADD, ADHD, more autism. Just look at human beings, we’ve never been so agitated. You know, everybody, and it might be a social media thing, but people take a position on something, and if anybody doesn’t share that position, they view them as the enemy. Dr. Deb Muth 00:44:29 And it’s kind of scary what’s happening to us. Bob Miller 00:44:33 So, we can’t agree to disagree anymore. We see anybody who has a differing opinion as the enemy. And, you know, there was… there’s people that didn’t have Christmas dinners together, because they had political differences, like… Dr. Deb Muth 00:44:44 Excuse me. Bob Miller 00:44:45 can’t you put your political differences aside to have Christmas together, you know? Dr. Deb Muth 00:44:49 Right? Bob Miller 00:44:50 become that, you know, no matter what your position is, and I’m not saying anyone’s right or wrong, I’m just saying. You know, in the old days, they used to say that the Republicans and Democrats in Congress would argue policy and then go have dinner together. And now everybody’s all up in arms, angry. Dr. Deb Muth 00:45:05 Yeah. Bob Miller 00:45:06 So… There’s likely multiple reasons for that. But let me show you one of them. That, you know, to what degree this is… very important, we don’t know, but I think We’re beginning to believe this is very important. So, there’s something… there’s a neurotransmitter called GABA. And God buys the don’t worry, relax, be happy. Chill. Okay. Dr. Deb Muth 00:45:31 Nobody has enough of that anymore. Bob Miller 00:45:33 Well, yeah, you’ll be surprised what I’m gonna show you. So, let me see if I can find a, Let me see if I can find the right slide here. Let me look for it here. So, there’s something called a GABA receptor site. And here you can see… This is a neuron, and this is where you, The neuron normally is excitatory. However, there’s normally low chloride in the neuron. Dr. Deb Muth 00:46:09 Hmm. Bob Miller 00:46:10 So, GABA itself is neither relaxing. For excitatory, all GABA does, it opens up what’s called a chloride channel. And then chloride, which has a negative charge, will flow into the neuron. Follow me there? Dr. Deb Muth 00:46:26 Yep. Bob Miller 00:46:27 And as it does, it changes this from a positive charge to a negative charge, And it’s relaxing. and inhibitory. Dr. Deb Muth 00:46:34 Hmm. Bob Miller 00:46:36 Now, on the other hand, there’s enzymes called NKCC1, That will push chloride in. and KCC2 that will bring chlor… oops and bring chloride out. And then there’s a sodium channel. And, sodium has a positive charge. And glutamate will push that in. So, as long as this is happening. And GABA says, receptor sites, open, chloride goes in, Chill. However, If NKCC1 Pushes extra chloride in. KCC2 doesn’t pull it out. and GABA hits the receptor site, the GABA comes flowing out, Sodium comes in, And now it’s excitatory. So Gabba didn’t change. GABA just opened the receptor site, that’s all it does. Dr. Deb Muth 00:47:33 Yeah. Bob Miller 00:47:34 But it’s the chloride balance that’s going to determine whether this is relaxing or not. Now, these are the things that go along with when they lose that KCC2 or gain NKCC1. Pain and sensitivity, burning electrical, neuropathic pain. Normal touch hurts. Sound and light sensitivity. Tinnitus can flare. Headaches and migraines. Seizure tendency. Body jolts. Spasticity, cramps, stiffness, startle reflex. Trouble falling asleep, non-restorative sleep. Anxiety, stress, reactivity, that’s what we have now. Hyperarousal, panic-like surges, irritability, racing thoughts. Brain fog, slowed processing, working memory slip-ups. Mental fatigue. Episodes of racing hearts, sweaty palms, guts on edge. Those are all the things that happen when this GABA switch occurs. Now, here’s what happens, and this is what I’m going to be presenting at an autism conference. When you have a newborn, they need that NKCC dominant to develop. By early childhood, it should… or, sorry, early adulthood. we should move over to the KCC dominant, that’s the taking the chloride out. Nice-looking 25-year-old boys, functioning very well. However, when we get microglia M1 upregulated. Because of environmental toxins, processed foods, Tylenol, aluminum. they stay in NKCC1 dominant, and there’s ADD, ADHD, Autism, the whole spectrum. because… They’ve not moved over to the… They’ve not moved over to the KCC2. And again, this is caused by… Environmental factors. Stimulating the microglia. And then, interleukin-1, interleukin-18 weakens KCC2, interleukin-1 beta, Strengthens NKCC1. high chloride. We open up the chloride channel, In Rebell Excitatory. So, I think when, When the pediatricians get ahold of this, they’re going to be very excited to know that This could be why we’re seeing such a rise, and not just autism, but ADD, ADHD, anxiety, the whole shit mess. Dr. Deb Muth 00:49:58 thing. Bob Miller 00:49:59 Yeah, so… and you can see NF-kappa-B stimulates that. These stimulate it, and I think that’s why everyone’s getting so anxious. Now, there’s a little bit more to it, and we’ll get into this when we look at some of the maps, but… The, the glutamate, Which is excitatory. will stimulate the NMDA receptor, make more glutamate, And glutamate will inhibit KCC2. And then we also need an astrocyte To, take both ammonia And glutamate, and… Turn them back into glutamine. And I’m going to talk to you a little bit about arachidenic acid, and if we have too much arachidenic acid. or TNFA is upregulated, that doesn’t happen. Ammonia goes up, and there may be multiple reasons for this, but this is a reason why some of the autistic kids do flapping. Dr. Deb Muth 00:50:49 Hmm. Bob Miller 00:50:50 Because they’re not clearing their ammonia. And you can tell if somebody has high ammonia by… they get that old person smell, you know. Dr. Deb Muth 00:51:00 Yup. Bob Miller 00:51:01 your vehicle cycle’s not taking out the, the ammonia. Now, last pathway here. There’s growing interest in mast cell activation. So, back here, we talked about peroxynitride. And that will stimulate mast cells, and those are white blood cells that are your best friend, unless they’re your worst enemy. Then it’ll make histamine. And there’s enzymes called histidine decarboxylase that’ll make more. Dr. Deb Muth 00:51:28 I’m sure everybody’s heard of DAO, the enzyme that degrades histamine. Yep. Bob Miller 00:51:31 We can have genetic weakness, we don’t make that. There’s an enzyme called histamine and methyltransferase, That, That breaks down the histamine. Then if we don’t do that, it’ll get stuck in the histamine receptor site. And then it’ll make something called, renin. Which will cause angiotensinogen to turn into angiotensin. One, that turns into angiotensin II,And that’s where people make aldosterone, where they’ll get the, The swollen ankles and high blood pressure. But interestingly, there’s an enzyme called ACE2, that takes this guy and turns it into angiotensin 1-7, Which is anti-inflammatory and also inhibits… TNFA. Now, you can have weakness on ACE2, But… and anybody’s saying, that sounds familiar? Dr. Deb Muth 00:52:25 That’s where COVID comes in, using ACE2. Bob Miller 00:52:28 And now we just found there’s literature that if you get COVID long enough, it can actually make ACE2 not be able to work as well. So look what it does. It comes down here, stimulates the NADPH oxidase, More superoxide. More peroxynitrite. And we’re on a cycle here. We’ve actually named this the Home Cycle Hypothesis, the proposed feed-forward loop. That just keeps feeding on itself. All being caused by… Primarily, The environmental factors. But hitting those who have genetic weakness the hardest. That’s why. Dr. Deb Muth 00:53:08 To the people. Bob Miller 00:53:09 Don’t live in a moldy house. One person is sick as can be, and the other person says, well, you must be imagining things, because I don’t feel anything. Dr. Deb Muth Yeah. Same thing with long haul, right? Two people can both get sick, one gets sick and never seems to recover, and somebody else gets sick, and they have absolutely no problems with it at all. Bob Miller 00:53:30 Sure. Well, think about it, if you get COVID, and ACE2 is weak, and some of this other stuff is going on. This thing just starts feeding upon itself. Dr. Deb Muth 00:53:38 Keep creating more inflammation, more complications, nothing’s calming down. Bob Miller 00:53:43 Yeah. Now, you, you ask about, MTHFR. So, this is the, this is the, the software called Functional Genomic Analysis. There’s a demo report we have. So, let’s talk a little bit about, MTHFR. So, we actually have a map called a methylation map. Now, what happens is, when you do your saliva test, you, you know, you spit, you put some saliva. in a collection kit, goes to a lab, takes out the DNA data, sends it to the computer, and now you can actually see it visually. Okay. So, it’s gonna take a second for this, data to load up, it’s, and each of these Circles, each of these ovals, is an enzyme. And the data gets loaded up to see where it is. So, until it gets loaded up here, I didn’t preload this. There it goes. So… The primary thing about methylation is There’s a nasty substance called homocysteine that, if it’s too high, can really be detrimental. The body takes methylfolate, and combines with methyl B12, To bring this back up to methionine. And then through the MAT genes, we make SAMI, S-adml methionine. Which is involved in so many processes. Then after it does its thing, it turns back into homocysteine. And this thing needs to keep spinning around. That’s why, you know, it’s a good idea to keep homocysteine at, do you have a number that you’d like? 7, 8? What do you like for a number? Dr. Deb Muth 00:55:24 Yeah, I like mine below 7. Bob Miller 00:55:26 Yeah. So if the homocysteine goes too high. It, caused all kinds of problems. So, here’s where you ask about the MTHFR. So, here you can see on this individual. I click on MTHFR, and you can see it comes up here, here’s the C677. And you can see here where it says, variants. I’ll… I’ll draw in case somebody’s having a hard time seeing that. So, you can see there’s nothing in there. That means there’s no genetic mutations. If one parent would have given a mutation, there’d be a 1. If both parents did, there’d be a 2. Now, here’s why Yes, methylation is important, I’m not saying it isn’t important, but look at this MTHFRC677. In my software. Only 42.5% of the population does not have a mutation. 44.7% have won. 12.9 have 2. So, this isn’t some rare, oh my god, I’m gonna die… Kind of thing, yeah. Dr. Deb Muth 00:56:27 Right. Bob Miller 00:56:28 So, And then what happens is that, and again, I’m not dismissing methylation, I… we could do a whole show on methylation. Bob Miller 00:56:36 get it. But I think that what people are doing is they’re, they’re learning about MTHFR, they get it measured, they panic. They start taking massive amounts of methylfolate, which many times is to their detriment. Dr. Deb Muth 00:56:50 Well, it’s… and isn’t it true, too, with MTHFR, like, you have to also look at MTR, MTRR, and the more we stack up of those, the more complicated than MTHFR can be. It’s not… it’s not as simple as just saying MTHFR 677 versus 1298. It’s more complex than that, kind of like what you’ve already shown with some of the other things. There’s more to it than just that one little sliver. Bob Miller 00:57:17 Oh, sure, well, let’s take a look. So, remember I said there’s a cofactor? One of the cofactors is called FAD. Just a Bob Miller observation, that’s all. But when people have trouble with their riboflavin and they don’t have enough FAD, They’re doing much worse than people who have just a C677. So, right here, you could have perfect C677th. And if you don’t have the cofactor, it’s not gonna work, okay? Dr. Deb Muth 00:57:48 And as you said, there’s an MTR enzyme. Bob Miller 00:57:51 that takes methylfolate and methyl B12, to spin it around. So, here on this individual. here’s your… here’s your B vitamins, or I’m sorry, your B12s. There’s an enzyme called TCN1 that takes it from the stomach into the blood. Then there’s other enzymes that take it from the blood into the tissue. And if you’re having trouble here. Well, then you’re not going to have this working, so… Even if you don’t have MTHFR, And you have MTR, like this, no, I’m sorry, this person doesn’t. But they have the MTRR, and then they don’t have enough B12, this isn’t gonna work, aside from that. And then there’s a middle pathway. And then there’s enzymes called the MAT1. they take the methionine to the salmon. If that’s not working, we stick… we get stuck in methionine. So, it’s, it’s not just an MTHFR. And then, one of the things that people forget about. is through these CBS enzymes and CTH, We make cysteine, which is needed to make glutathione. The master antioxidant. So, it really is that… I call it the, The 3D chess game played underwater. Dr. Deb Muth 00:59:07 It really is. I mean, I see people who have CVS, COMT, glutathione, MGHFR genes. And some of them function just fine. Like, they have Like, I look at this person and I’m like, oh my gosh, I don’t know how they’re functioning because they’re double mutated on so many pathways, but yet they don’t have a lot of symptoms, they don’t have a lot of complications. Somehow their body has figured out a way to adapt to what it has so it can stay alive and it can function at a high functioning level. Bob Miller 00:59:36 Yeah, and they may be, you know, eating right? Yeah. Staying out of a moldy house. reducing stress. So, it’s diet, it’s stress, it’s genetics, environmental factors. So, yeah, we can’t just say somebody’s gonna be good or somebody’s gonna be bad. You know, some people get scared, oh, I got all these, it’s like, well… Bob Miller 00:59:56 Are you living in a moldy house? You know, and if you live in a moldy house and your glucuronidation pathway doesn’t do well, or if you’re, you know, a smoker, or you’re constantly eating junk food, I mean, all. Bob Miller 01:00:07 things come together. Although, you know, when we focus on genetics, we’re well aware that this is just a piece of it. You know, you could have identical twins, Genetically, and if one… Is exposed to mold and smokes and drinks and stressed out. They’re gonna be a whole lot sicker than their sibling. Bob Miller 01:00:28 Yep. Dr. Deb Muth 01:00:29 Yeah, it’s that concept of taking twins, and one gets raced with one family, and one gets raced with another family, and they don’t have the same… problems that… that each other have, you know? It’s a very unique situation, we don’t think about that enough. Bob Miller 01:00:44 Alright, so again, genetics loads the gun, environment pulls the trigger. So, if you’ve got a loaded gun, but you don’t have the triggers, you’re okay. Dr. Deb Muth 01:00:53 Yeah. Bob Miller 01:00:54 Yeah. So, remember I said I was going to talk about NAD? So, here’s NAD, and what it does, it turns into NADH. And what NADH does, it, Comes down this pathway, what’s called the electron transport chain. And that makes your ATP, that’s your energy. So, if this wasn’t working, we wouldn’t be alive, because we wouldn’t have energy. So it donates an electron, that’s why it’s called electron transport chain. So, we need NAD, To make this, to make the energy. But remember I said that NQ01, this would probably be, like, on my top 10 list of… Bob Miller 01:01:36 Much more important than MTHFR. This one takes NADH back to NAD. If we’re stuck over here, We’re low in this NAD+, But what happens is, NQO1 also provides CoQ10. And CoQ10 Is what’s needed for the electron transport chain to flow. So if we get too many electrons up here. And they don’t turn them into energy. They make a nasty free radical called superoxide. Okay. Now, NAD plus also makes NADPH, And that is needed. Remember I said we need to recycle our antioxidants. So, if we have a problem with FAD from riboflavin. Yeah, we don’t have enough NADPH, Glutathione’s not getting recycled, and you’re gonna be inflamed. And you take glutathione, you’ll feel worse. There’s another enzyme called thimoredoxin. Same thing, needs NADPH and FAD. And same way with your nitric oxide, there’s an enzyme called NOS3, That makes the nitric oxide that dilates your blood vessels. And if we don’t have enough NADPH or fat, You’re gonna make superoxide. Rather than nitric oxide. Now, remember

This episode is brought to you by the⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Primal Tallow Soaps & Balms.⁠⁠⁠⁠⁠⁠⁠⁠ Join us as cardiologist Dr. Pradip Jamnadas (MD) explains the link between chronic inflammation and visceral fat. In this episode, we explore how high insulin levels act as a metabolic brake, preventing fat oxidation and cellular renewal. Dr. Jamnadas shares his vast cardiovascular expertise to explain the science of cellular autophagy and why prolonged fasting is a clinical powerhouse for cellular repair. By shifting the focus from calories to hormonal optimization, this episode offers a masterclass in preventative medicine. This episode is essential for anyone interested in the science of fasting, both intermittent fasting and the magic of the 36 hour fast, and how it can improve metabolic flexibility. In This Episode, We Reveal:The Dangers of Visceral Fat: A clinical review of why ectopic fat storage in the abdominal cavity is the primary driver of systemic inflammation and cardiovascular disease.The Insulin-Adipose Connection: Understanding the hormonal "lock" that prevents the mobilization of stored energy and how fasting restores insulin sensitivity.Autophagy & Cellular Maintenance: A scientific breakdown of the body's innate repair mechanism and the specific fasting durations required to trigger protein recycling.The "Starvation" Myth vs. Clinical Fasting: Differentiating between nutrient deprivation and the controlled, physiological state of metabolic switching.Electrolytes & Metabolic Support: Why sodium, magnesium, and potassium are non-negotiable for maintaining cardiovascular stability during extended fasting windows.Worst foods: Identifying the "healthy" processed foods that trigger metabolic dysfunction and the four nutrient-dense pillars of health.

Dr. Fuhrman explains the healing power of time-restricted eating, meal timing, and how proper digestion supports long-term recovery. #FastingBenefits #SleepAndDiet #MealTiming

The melanocytes giving pigment to your skin right now might be older than your car. They have been sitting in your dermis for decades, and unlike the cells on your skin's surface, they do not get replaced. They have to keep themselves clean which happens through autophagy.In Part 2 of our autophagy deep dive, we get specific about how skin handles autophagy differently from other parts of the body. We unpack why long-lived cells like fibroblasts and melanocytes depend on this cleanup process, what happens when it fails, and how it ties directly to gray hair, hyperpigmentation, sagging skin, and that brownish dullness no serum seems to fix.We also introduce one of the most overlooked players in this entire conversation, and explain why we believe it is the next NAD. If you want to understand what is actually happening underneath your skin as it ages, and what tools we have to intervene at the cellular level, this episode is for you.What's Discussed:(01:06) Why skin needs autophagy more than almost any other organ(03:07) The cells on your face that may be older than your car(04:25) The 2013 paper that linked autophagy failure to dermatitis(08:44) Zombie mitochondria and why photo-aged skin makes bad collagen(12:25) Senescent cells, SASP, and how a few bad cells poison the dermis(18:38) The 2019 Drexel rapamycin trial that proved this works in humans(23:22) The 2024 spermidine study that changes how we think about autophagy(29:51) Why your skin barrier collapses without this one moleculeResources Mentioned:Biohacking Beauty Podcast with Dr. Scott Sherr: Stress & Light on Your Skin Are Aging Your Entire Body Podcast/dr-scott-sherr-stress-light-on-your-skin-are-aging/2024 Study on endogenous spermidine as essential for rapamycin-induced autophagy and longevity: pubmed.ncbi.nlm.nih.gov/39212197/Young Goose Companion Booklet: younggoose.com/pages/autophagy-skin-activate-your-bodys-anti-aging-system Find more from Young Goose:Use code PODCAST10 to get 10% OFF your first purchase, and if you're a returning customer use the code PODCAST5 to get 5% OFF at younggoose.comInstagram: @young_goose_skincare

What if your skin could literally rebuild itself from the inside out? In this episode, we break down one of the most powerful and misunderstood biological processes in the human body: autophagy.From its Nobel Prize-winning discovery to the molecular machinery that drives it, we walk you through exactly what autophagy is, how it works at the cellular level, and why it matters far more than most people realize for skin aging.We explore the two master switches that control autophagy, mTOR and AMPK, and how the constant tug of war between them determines whether your cells are in build mode or cleanup mode. We also explain why most people in the modern world are stuck in permanent mTOR activation, and what that means for how their skin ages over time.This is Part 1 of our deep dive. In Part 2, we go skin-specific and break down exactly how autophagy renews your skin at the tissue level.What's Discussed:(0:19) The "phoenix process": the cellular mechanism rebuilding your skin from the inside out(3:14) What autophagy actually means, and why the science world ignored it for 30 years(4:47) How baker's yeast cracked the code that won the 2016 Nobel Prize(7:14) Inside a single skin cell: the step-by-step breakdown of how autophagy actually works(10:22) Why autophagy is not destruction, and what this means for your collagen supplements(16:44) The two master switches controlling whether your cells build or clean(20:10) The everyday habit silencing your body's most powerful anti-aging system(26:17) Why aging skin isn't broken, it has just never been told to cleanResources Mentioned:Biohacking Beauty Podcast: Ben Azadi: Why 93% of Americans Are Aging Too Fast + What to Do About It: podcasts.apple.com/us/podcast/ben-azadiFind more from Young Goose:Use code PODCAST10 to get 10% OFF your first purchase, and if you're a returning customer use the code PODCAST5 to get 5% OFF at younggoose.comInstagram: @young_goose_skincare

In this episode, Dr. Jockers breaks down the science of autophagy and mTOR, two crucial processes for cellular repair and growth. Learn how balancing these pathways is key to slowing down aging and optimizing longevity. Discover the powerful impact of fasting, exercise, and ketosis on activating autophagy and inhibiting mTOR. Dr. Jockers explains how these strategies help reduce inflammation and promote healthy muscle mass. You'll also hear about the best foods and supplements to support your body's natural healing processes. From polyphenols to intermittent fasting, this episode gives you the tools to boost cellular regeneration and maintain vitality. In This Episode:  00:00 Autophagy Basics 00:23 Podcast Intro and Resources 03:28 mTOR Explained 04:21 Autophagy and AMPK 05:11 Longevity Risks and Balance 07:10 How to Inhibit mTOR 08:55 What Increases mTOR 12:21 Exercise Spring Load Strategy 13:22 Fasting Window and Meals 16:17 Longevity Takeaways and Outro   Unwind with Purality Health's KSM 66 Ashwagandha, clinically proven to reduce stress and improve overall health. Its advanced nano-absorption technology ensures you get this ancient herb's full benefits. Experience better sleep, enhanced memory, and a calmer mindset. Enjoy a special buy one, get one free offer now! Each order comes with a six-month satisfaction guarantee. Visit longevityroot.com/drj to claim your deal and start feeling less stressed today. Say goodbye to unhealthy cooking oils and elevate your meals with Kettle & Fire's 100% grass-fed beef tallow. Free from seed oils and preservatives, it's the cleanest, healthiest fat you can use for cooking. With a high smoke point of 420°F, it's perfect for grilling, roasting, and sautéing, bringing both great flavor and nutritional benefits. For a limited time, enjoy 25% off sitewide with the code DRJOCKERS at checkout. Visit kettleandfire.com/drjockers to shop now!   "Autophagy clears out what's broken so your body can rebuild stronger, cleaner, and more efficient cells." ~ Dr. Jockers   Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean TuneIn Radio     Resources: Visit renewyourhair.com/drj to claim your exclusive offer Visit kettleandfire.com/doctorjockers with the code DRJOCKERS   Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https:/www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/   If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/ 

Urolithin A (MitoPure)--Mitophagy, Muscle Recovery, Immunity, and Skin Health: Dr. Brad Currier, clinical trial manager at Timeline, a Swiss biotech company, details urolithin A (MitoPure), a postbiotic derived from pomegranate precursors that most people cannot produce due to microbiome differences. Currier explains MitoPure's mechanism—stimulating mitophagy to recycle dysfunctional mitochondria—and reviews evidence from multiple clinical trials. He reveals a Sports Medicine study in elite male distance runners showing reduced creatine kinase and lower perceived exertion, suggesting improved recovery, plus trials in middle-aged and older adults showing improvements in strength, six-minute walk test, and VO2 max at 500 mg–1 g doses. They also cover a Nature Aging immune study reporting rejuvenation of stem-like CD8 T cells with improved mitochondrial fatty acid oxidation, ongoing research directions, supplement quality/testing for athletes, and topical urolithin A skincare trials and partnerships, including L'Oréal Lancôme.

In this episode, Dr. David Jockers dives into the transformative benefits of a seven-day water fast. He explores how fasting balances blood sugar, improves insulin sensitivity, and triggers deep cellular healing, making it a powerful tool for weight loss and overall health.   You'll learn how fasting helps the body burn fat, repair mitochondria, and reset the immune system. Dr. Jockers breaks down the science behind autophagy and mitophagy, showing how your body eliminates damaged cells to replace them with healthier, stress-resistant ones.   Plus, discover the critical role ketones play in brain health and how fasting elevates stem cell production. With insights on how to prepare for and break a fast, you'll get practical tips for maximizing the benefits of extended fasting. In This Episode:  00:00 Key Fasting Milestones 04:17 Why Fast Seven Days 04:53 Blood Sugar and Fat Burn 06:23 Ketones and Brain Benefits 07:40 Autophagy and Mitochondria 08:37 Gut Microbiome Reset 10:20 Hormones Longevity Stem Cells 16:06 Research and Immune Tregs 18:08 Hour by Hour Breakdown 20:07 Five vs Seven Days 21:03 What to Drink While Fasting 22:54 Prep Meals Before Fasting 24:19 How Often and Exercise 25:29 Breaking the Fast Safely 26:50 Wrap Up and Final Thanks   Hair loss isn't just about age—it's about hair follicles getting stuck. AnaGain Nu by Purality Health uses a pea sprout extract clinically shown to reactivate follicles and boost regrowth. With their micelle liposomal delivery, your body absorbs it fast and effectively. Try it risk-free with a 180-day money-back guarantee and get a buy-one-get-one-free deal at RenewYourHair.com -  https://renewyourhair.com/drj.   Looking to boost your hair growth and enhance your skin health? Now's the perfect time to try iRestore's Elite Laser Hair Growth System and the Illumina Face Mask, both designed to give you thicker hair and smoother, more radiant skin. Take advantage of the Memorial Day savings event and grab this powerful bundle at an exclusive discount. Visit iRestore.com  and use code DRJOCKERS to claim your offer today.   "Fasting for 36–48 hours can reset your brain and dopamine, giving you a clearer mind and better mental health." ~ Dr. Jockers   Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean TuneIn Radio   Resources: Reignite hair growth with AnaGain Nu, risk-free with a 180-day guarantee and a buy-one-get-one-free deal! https://renewyourhair.com/drj Visit iRestore.com  and use code DRJOCKERS to claim your offer today Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https:/www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/   If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/ 

What happens when you stop eating after 6 p.m.? Discover the connection between your metabolism and fasting so you understand when to eat and when not to eat, plus the benefits of having no food after 6 p.m.0:00 Introduction: What happens when you stop eating after 6 p.m.? 0:15 What to eat vs. when to eat0:50 Autophagy fasting benefits1:28 Late-night eating dangers3:01 Dopamine and late-night snacking4:03 How to stop eating after 6 p.m. Download Dr. Berg's Free Daily Health Routine: https://drbrg.co/45qtO07Eating after 6 p.m. can interfere with your body's natural repair system. Even if you're eating clean, nutrient-dense foods, late-night eating may still negatively impact your metabolism, recovery, and overall health.At night, your body is designed to enter autophagy, a deep cellular “clean-up” process where damaged cells and mitochondria are repaired and recycled. Autophagy only occurs when insulin levels are low. Every time you eat, insulin rises, which can interrupt this critical overnight repair cycle. This is why fasting after 6 p.m. is critical for optimal metabolic and cellular health.Late-night eating can also disrupt melatonin production, affecting sleep quality and recovery. Poor sleep then impacts digestion, increases stress hormones like cortisol, and can lead to unstable blood sugar levels the following day.Another major driver of late-night snacking is dopamine hunger. This is when cravings are triggered not by true physical hunger, but by boredom, stress, fatigue, or emotional habits, leading to unnecessary eating when the body should be resting and repairing.Dr. Eric Berg DC Bio:Dr. Berg, age 61, is a chiropractor who specializes in Healthy Ketosis & Intermittent Fasting. He is the Director of Dr. Berg Nutritionals and author of the best-selling book The Healthy Keto Plan. He no longer practices, but focuses on health education through social media.Disclaimer: Dr. Eric Berg received his Doctor of Chiropractic degree from Palmer College of Chiropractic in 1988. His use of “doctor” or “Dr.” in relation to himself solely refers to that degree. Dr. Berg is a licensed chiropractor in Virginia, California, and Louisiana, but he no longer practices chiropractic in any state and does not see patients, so he can focus on educating people as a full-time activity, yet he maintains an active license. This video is for general informational purposes only. It should not be used to self-diagnose, and it is not a substitute for a medical exam, cure, treatment, diagnosis, prescription, or recommendation. It does not create a doctor-patient relationship between Dr. Berg and you. You should not make any change in your health regimen or diet before first consulting a physician and obtaining a medical exam, diagnosis, and recommendation. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition.

Leslie Kenny was told in her 30s that she had five years to live. Diagnosed simultaneously with lupus, rheumatoid arthritis, and Hashimoto's thyroiditis — and told to give up her dream of having children — she did what true Betties do: she refused the prognosis, threw everything she had at it, and got to work. Now 60 years old, Leslie reports a biological age of 21. She is autoimmune disease-free. And she naturally conceived a child at 43. Her recovery journey led her to collaborate with University of Oxford scientists and to discover spermidine — a naturally occurring, food-derived longevity compound that was hiding in plain sight. It's been in our food for millennia, it's in breast milk, and it's in every plant on earth. And it addresses 9 of the 12 hallmarks of ageing identified by science as the root causes of why we get older. For 20% off Primeadine, go to: https://www.oxfordhealthspan.com/DRSTEPHANIE  Episode Overview (timestamps are approximate): (0:00) Intro/Teaser (4:00) What Is Spermidine and Why Do We Lose It? (8:00) Autophagy, Hair, Nails & the Biological Dashboard (17:00) The 12 Hallmarks of Ageing, Explained for Real Life (23:00) mTOR, Muscle Loss, and Why Spermidine Is Different (27:00) Food Sources, Dosage & Lifestyle Levers (38:00) Leslie's Story: The Diagnosis, the Prognosis, the Refusal (55:00) IVIG, Trauma Therapy & the Surprise Pregnancy at 43 (1:18:00) Femspan, Future Research & Where to Find Leslie (1:22:00) The After-Party Thoughts with Dr. Stephani Resources mentioned in the Episode can be found at: https://drstephanieestima.com/podcasts/ep464  We couldn't do it without our sponsors: JUST THRIVE HEALTH - Take the Just Thrive FEEL BETTER challenge today, and save 20% on your first order. Go to https://justthrivehealth.com/better and use the code BETTER to see the difference for yourself. BON CHARGE - Achieve glowing skin, gain more energy, and uplevel your recovery practice with a suite of red light products. Get 15% off at https://boncharge.com/better with code BETTER. HIGHER DOSE - If you're noticing thinning, shedding, or simply want to support scalp and hair health proactively, this is a powerful addition to your routine. Get 15% off the Red Light Hat at https://higherdose.com with code BETTER at checkout. KENETIK - You think carefully about how you fuel your body but are you fueling your brain? Learn more about Kenetik and try it for yourself by going to https://drinkkenetik.com/BETTER and use code BETTER for 15% off QUALIA LIFE - Boost energy, DNA health, and cellular protection. Save 15% at https://qualialife.com/better with code BETTER. ****************************P.S. When you're ready, here are two ways Dr. Stephanie can help you:Subscribe: The Mini Pause — My weekly newsletter packed with the most actionable, evidence-based tools for women 40+ to thrive in midlife.Build Muscle: LIFT — My progressive strength training program designed for women in midlife. Form-focused, joint-friendly, and built for real results. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In this episode, Dr. Jockers dives into the benefits of fasting for 8 hours before bed and how it can trigger fat burning and enhance cellular healing. By reducing insulin levels, your body starts utilizing fat as fuel, unlocking the power of autophagy for deeper detoxification and repair.   You'll discover how this fasting window supports mitochondrial function, improving energy production and brain health. Dr. Jockers explains the key role of healthy mitochondria in fat burning, memory, and overall vitality.   Plus, learn how fasting helps reset your gut microbiome, trimming down harmful bacteria and promoting beneficial ones that improve digestion and immune function. In This Episode:  00:00 Primary and Secondary Feeders 03:15 Eight Hour Fast Overview 03:44 Insulin Drop and Autophagy 05:42 Growth Hormone and Melatonin 08:24 Gut Microbiome Reset 15:54 Meal Prep for the Fast 18:50 Light and Sleep Hygiene 20:20 Exercise and Drink Rules 23:02 Extra Biohacks and Detox 25:52 How Often and Wrap Up   Hair loss isn't just about age—it's about hair follicles getting stuck. AnaGain Nu by Purality Health uses a pea sprout extract clinically shown to reactivate follicles and boost regrowth. With their micelle liposomal delivery, your body absorbs it fast and effectively. Try it risk-free with a 180-day money-back guarantee and get a buy-one-get-one-free deal at RenewYourHair.com -  https://renewyourhair.com/drjm/DRJ.   If you're feeling wired, tired, and depleted, it's time to replenish your electrolytes with Relight from Redmond. Made with Redmond's Real Salt, this clean formula provides essential electrolytes like sodium, potassium, and magnesium without any sugar or artificial ingredients. Perfect for those under stress, fasting, or living an active lifestyle, Relight helps restore hydration, improve energy, and support mental clarity. Visit https://redmond.life/drjockers and use code JOCKERS for 15% off today!   "When insulin drops, your body starts burning fat for fuel—unlocking the healing power of autophagy." ~ Dr. Jockers     Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean TuneIn Radio     Resources:   Reignite hair growth with AnaGain Nu, risk-free with a 180-day guarantee and a buy-one-get-one-free deal!  RenewYourHair.com/drjm/DRJ Visit https://redmond.life/drjockers and use code JOCKERS for 15% off today Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https:/www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/   If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/ 

Dr. Rhonda Patrick, PhD, is a biomedical scientist and public science educator. She shares the exercise, nutrition, supplementation and lifestyle practices linked to better health and lower disease risk including specific cardio and resistance training routines, when and why to do intermittent fasting, ways to lower visceral fat, omega-3 sourcing, creatine for brain and muscle and peptides such as BPC-157. It's broad and thorough coverage of how to build a total health program tailored to your goals and individual biology. Read the show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Our Place: https://fromourplace.com/huberman Lingo: https://hellolingo.com/huberman LMNT: https://drinklmnt.com/huberman Function: https://functionhealth.com/huberman Mateina: https://drinkmateina.com/huberman Timestamps 00:00:00 Rhonda Patrick (00:02:40) Competition, Jumping Rope, Rope Flow (00:06:49) Rhonda's Exercise Routine, Cardiovascular & Resistance Training (00:12:30) Cognitive & Physical Benefits of Exercise, Serotonin & Impulse Control (00:14:40) Sponsors: Our Place & Lingo (00:17:03) Phones While Training? (00:18:45) Rhonda's Strength Training, Low-Reps, Modifications, Mental Resilience (00:27:00) Daily Protein Intake, Intermittent Fasting, Processed Carbohydrates (00:33:32) Lipopolysaccharide (LPS); Gut Permeability, Gluten; Cardiovascular Health (00:42:58) Sponsor: AG1 (00:44:21) Tight Junctions, Gut, Neuroinflammation (00:47:26) L-glutamine, Immune System, Cancer Risk (00:54:55) N-acetylcysteine (NAC), Vitamin E; Antioxidant Balance, Reductive Stress (01:00:08) Starch, Tool: Bedtime Fast & Cardiovascular Health (01:03:36) Cortisol, Intermittent Fasting Benefits (01:08:09) Cortisol, Train Fasted?; Hormones, Visceral Fat (01:13:35) Visceral Fat, Perimenopause/Menopause, Insulin Resistance in Brain & Body (01:21:13) Sponsor: LMNT (01:22:33) Cortisol & Sleep (01:25:42) Intermittent Fasting, Metabolic Switch, Ketones, Muscle Loss? (01:36:47) Tools: Logic-Based Habits; Daily Metabolic Switch; Exercise, Autophagy (01:45:06) Exercise After Poor Sleep?; Training Breaks (01:52:47) Tool: "Exercise Snacks"; Sedentary Lifestyle & Cardiorespiratory Fitness (02:03:31) Sponsor: Function (02:05:16) Creatine, Dose, Resistance Training, Cognitive Function (02:17:43) Biology; Creatine; Supplement Safety (02:25:18) Omega-3s, Inflammation, Cancer Risk, Vitamin D; Trans Fat (02:36:52) Magnesium Threonate vs Bisglycinate, Sleep, Cognitive Benefit; Vitamin D (02:45:46) Supplement Types, Multivitamin, Coenzyme Q10, Urolithin A, Sulforaphane (02:55:10) Microplastics (02:57:26) Sponsor: Mateina (02:58:28) BPC-157, NMN, NR, Tool: Evaluating Supplements, Safety, Sources (03:06:28) L-Carnitine, Alpha-GPC, Nicotine, GABA & Ketogenic Diet (03:15:20) Nattokinase; Microplastics, Water Bottles; Seed Oils (03:22:21) Sauna, Creatine for Kids?, Bananas, Tool: Evaluating Studies (03:28:37) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices