Podcast appearances and mentions of morgan levine

There is a lot of common summertime advice. For example, don't go swimming for a half hour after you eat. Don't scratch a bug bite. Don't touch someone who has poison ivy because you might catch it. Are these things true or summertime folklore? This episode starts with some answers. https://www.silive.com/healthfit/2012/07/summer_myths_debunked.html Do you know what toxic positivity is? It's the philosophy that says to look on the bright side. Try to stay positive no matter what. Don't worry – everything's going to be just fine. We often say these things to comfort people, but it may be doing more harm than good. That's according to my guest, Whitney Goodman. She is a licensed marriage and family therapist and author of the book, Toxic Positivity: Keeping It Real in a World Obsessed With Being Happy (https://amzn.to/3cwrhcf).  You may know your chronological age, but do you know your biological age? There is pretty strong evidence that how you live your life can accelerate or roll back your biological age, according to my guest, Morgan Levine. She is an assistant professor of pathology at Yale University School of Medicine and author of the book, True Age: Cutting-Edge Research to Help Turn Back the Clock (https://amzn.to/3zaRepw). Listen as she explains what you can do to slow or reverse the aging process so you stay as young as you can for as long as you can.  The old advice to, “Stop and smell the roses” may be more important than you ever thought. It appears the scent of a rose can improve your memory, your dreams and even your happiness. Listen as I explain. https://www.dailymail.co.uk/sciencetech/article-1059329/How-sweet-dreams–simply-smell-roses.html and https://www.nature.com/news/2007/070305/full/news070305-10.html Learn more about your ad choices. Visit megaphone.fm/adchoices

Age expert Dr. Morgan Levine explains why living to 100 is the wrong goal. Dr. Morgan Levine suggests that we should aim for living better, not just longer. In her book, “True Age,” Levine introduces the idea of healthspan, which is about staying healthy and enjoying life, rather than merely adding years to it. She explores the concept of “compression of morbidity,” a goal to squeeze most of our inevitable ailments into a short period before we die, mirroring the patterns seen in people who live to 100 or more. Levine also highlights a paradox: Women generally outlive men, but they also endure more age-related illnesses. Ultimately, she argues that the benefits of longevity science should be accessible to everyone, with the goal of health disparities rather than increasing them. Chapters: 0:00 The immortality obsession 0:30 The male-female survival paradox 1:34 Prolonging healthy life 2:07 Squeezing morbidity into fewer years 3:05 LIfe extension for all About Morgan Levine: Morgan Levine was previously a tenure-track Assistant Professor in the department of Pathology at Yale University where she ran the Laboratory for Aging in Living Systems. In 2022, she was recruited to join Altos Labs as a Founding Principal Investigator at the San Diego Institute of Science. She currently leads a research group at Altos Labs working at the intersection of bioinformatics, cellular biology, complex systems, and biostatistics with the overall goal of understanding the molecular trajectories aging cells, tissues, and organisms take through time. About Big Think | Smarter Faster™ ► Big Think Our mission is to make you smarter, faster. Watch interviews with the world's biggest thinkers on science, philosophy, business, and more. Get Smarter Faster, With Daily Episodes From The Worlds Biggest Thinkers. Follow Big Think Leave A 5 Star Review --- Send in a voice message: https://podcasters.spotify.com/pod/show/bigthink/message Learn more about your ad choices. Visit megaphone.fm/adchoices

5 health experts, including Harvard professor Daniel Lieberman, share the exact ways exercise can lead to a healthier lifespan. In this interview, health experts Eric Kandel, Daniel Lieberman, Morgan Levine, Jillian Michaels, and Wendy Suzuki discuss the controllable nature of aging, citing how exercise can lead to a healthier lifespan. They highlight the specific ways exercise can reduce memory loss, prevent diseases, and maintain overall health. -------------------------------------------------------------------- Go Deeper with Big Think: ►Become a Big Think Member Get exclusive access to full interviews, early access to new releases, Big Think merch and more. ►Get Big Think+ for Business Guide, inspire and accelerate leaders at all levels of your company with the biggest minds in business. -------------------------------------------------------------------- Get Smarter, Faster. With Episodes From The Worlds Greatest Thinkers. Follow Big Think. Turn On The Notifications And Share This Episode. --- Send in a voice message: https://podcasters.spotify.com/pod/show/bigthink/message Learn more about your ad choices. Visit megaphone.fm/adchoices

Former Yale professor Morgan Levine explains how to calculate your ‘bio age' to live longer. How old are you? Odds are your answer is a number of years — a metric known as your "chronological age." Although this number isn't meaningless, it fails to capture the full picture of aging. Your "biological age" may be a far more useful metric. This is the degree to which your biology has changed over a given period of time. “Aging is starting at a molecular level, and over time this is going to give rise to all the functional changes and manifestations that we tend to see with aging,” says Dr. Morgan Levine, author of the book True Age. Unlike chronological age, your biological age is malleable: Scientists know that it's possible to slow biological aging by maintaining a healthy lifestyle. But is it possible to actually reverse the aging process? See what Dr. Levine has to say about the potential of anti-aging research in this Big Think interview. Chapters: 0:00 The aging illusion 1:42 Chronological age vs biological age 3:17 Your biological age is malleable 4:32 Measuring biological age 6:26 How to find out your biological age 6:54 Get informed, change your age 7:25 Can we reverse aging? About Big Think | Smarter Faster™ ► Big Think Our mission is to make you smarter, faster. Watch interviews with the world's biggest thinkers on science, philosophy, business, and more. Get Smarter Faster, With Daily Episodes From The Worlds Biggest Thinkers. Follow Big Think Share This Episode With A Friend Leave A 5 Star Review --- Send in a voice message: https://podcasters.spotify.com/pod/show/bigthink/message Learn more about your ad choices. Visit megaphone.fm/adchoices

Science can't stop aging, but it may be able to slow our epigenetic clocks. What if we could slow down the hands of our biological clocks? This question underpins much of the research of Morgan Levine, who leads a research team at the life science company Altos Labs. Levine investigates the fascinating intricacies of aging, recognizing that it doesn't happen at a uniform pace for everyone. Central to her exploration is the concept of epigenetics — the factors that influence gene activity without changing the DNA sequence. Levine focuses on DNA methylation, a significant epigenetic change that occurs with aging, and the development of models called "epigenetic clocks" that can be used to predict biological age. While she acknowledges that it might be possible to reverse aging at a cellular level, Levine clarifies that the ultimate goal is not to "cure" aging or death, but to delay disease onset and improve healthspan. Chapters: 0:00 Fast agers & slow agers 1:25 The hallmarks of aging 1:59 What is the epigenetic clock? 3:05 Can we ‘Benjamin Button' aging? 5:22 The holy grail for scientists Get Smarter Faster, With Daily Episodes From The Worlds Biggest Thinkers. Follow Big Think Share This Episode With A Friend Leave A 5 Star Review --- Send in a voice message: https://podcasters.spotify.com/pod/show/bigthink/message Learn more about your ad choices. Visit megaphone.fm/adchoices

Former Yale professor Morgan Levine shares 3 ways to change your diet to extend your life. Dr. Morgan Levine, author of "True Age," explains how the impact of diet on aging and longevity is determined by three factors: quantity, quality, and timing of food intake. First, caloric restriction, typically a 20% reduction in overall calorie intake, has been linked to increased lifespan in several animal models. However, the positive effects may stem from avoiding overeating rather than restriction per se. Second, a plant-based diet, with less animal products and refined sugars and more fruits, veggies, and whole foods, seems beneficial for aging and longevity. Third, fasting, or limiting eating to specific time windows, might mimic the benefits of caloric restriction by causing 'hormesis', mild stressors that boost resilience to aging-related changes. The optimal diet is likely individual, influenced by factors like genetics and age, and should be monitored through measures of biological age and personal well-being. Future research into aging biomarkers could further our understanding of diet's role in the aging process. Chapters: 0:00 Does diet affect aging? 0:35 #1 Caloric restriction 1:40 #2 What you eat 2:07 #3 When you eat: fasting 2:38 Hormesis: Building biological resilience 3:16 What is the optimal diet for you? ---------------------------------------------------------------------- About Morgan Levine: Morgan Levine was previously a tenure-track Assistant Professor in the department of Pathology at Yale University where she ran the Laboratory for Aging in Living Systems. In 2022, she was recruited to join Altos Labs as a Founding Principal Investigator at the San Diego Institute of Science. She currently leads a research group at Altos Labs working at the intersection of bioinformatics, cellular biology, complex systems, and biostatistics with the overall goal of understanding the molecular trajectories aging cells, tissues, and organisms take through time. Get Smarter Faster, With Daily Episodes From The Worlds Biggest Thinkers. Follow Big Think Share This Episode With A Friend Leave A 5 Star Review --- Send in a voice message: https://podcasters.spotify.com/pod/show/bigthink/message Learn more about your ad choices. Visit megaphone.fm/adchoices

Dr. Morgan Levine, a professor who specializes in the biology of aging, answers the internet's burning questions about aging. Is there anyway to stop aging? Is aging a disease? Do you age slower in space? Dr. Levine answers all these questions and much more! --- Send in a voice message: https://podcasters.spotify.com/pod/show/getu-chandler/message

Today, I am delighted to have the privilege of embarking on a journey through scientific discovery and the secrets that shape our existence with the esteemed Dr. Morgan Levine! Dr. Levine is an assistant professor of pathology at Gale University School of Medicine, where she stands at the forefront of a groundbreaking exploration into the enigma of biological aging. Armed with the tools of bioinformatics, she has unraveled the intricacies of aging, deciphering its code. She is the author of the book True Age, and her insights have enlightened those fortunate enough to peruse its pages!  Our discussion delves into the recesses of Dr. Levine's profound expertise, exploring the domains of biologic aging and epigenetics, unlocking the mysteries of cellular senescence, revealing the connections between lifestyle and longevity, and unearthing the reasons behind aging being considered a veritable disease state. We navigate the landscape of gender-specific aging research, gene influence exemplified by APOE, and the intriguing permanence of our youthful fat cells. We also get into the efficacy of blue zones and hormesis and the importance of exercise and sleep optimization.  Today's conversation with Dr. Levine promises a symphony of insight and discovery! Join us as we traverse the landscapes of longevity, epigenetics, and the science that might one day render age no more than a number. IN THIS EPISODE YOU WILL LEARN: How Dr. Morgan became interested in epigenetics. What telomeres are, and how aging impacts them. Why should aging be treated as a disease state? How taking probiotics can improve longevity. What can we do to slow the aging process? How can we reduce our risk of dementia? Intermittent fasting and weight loss. The role of exercise in preventing sarcopenia and muscle loss with aging. How do exercise and sleep impact our brains? The effects of being disconnected from our natural circadian rhythm. Connect with Cynthia Thurlow Follow on Twitter, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Connect with Dr. Morgan Levine On Twitter On Instagram Dr. Levine's book True Age: Cutting-Edge Research to Help Turn Back the Clock

We're thrilled to bring you this conversation with Hannah Went all about aging, biological clocks and epigenetics! She brings incredible insight into the options for testing your biological age, thoughts on telomere testing, the biggest drivers of aging, and what we can learn from the Dunedin pace of aging test. Tune in if you're interested in extending your healthspan! Hannah Went has a lifelong passion for longevity and breakthrough, disruptive technologies that drive radical improvement to the human condition. She attended the University of Kentucky and graduated with a degree in Biology. During that time, she had multiple research internships studying cell signaling and cell biology. After graduation, she worked for the International Peptide Society as their Director of Research and Content. Through work in the integrative medicine industry, Hannah saw an opportunity for methylation based age diagnostics and started TruDiagnostics in 2020. TruDiagnostic is a company focusing on methylation array-based diagnostics for life extension and preventive healthcare serving functional medicine providers. TruDiagnostic has a commitment to research with over 30 approved clinical trials investigating the epigenetic methylation changes of longevity and health interventions. Since TruDiagnostic's inception, they have created one of the largest private epigenetic health databases in the world with over 15,000 patients tested to date. Hannah has since created Everything Epigenetics where she shares insights on how DNA regulation has an impact on your health.SHOW NOTES:0:51 Welcome to the show!1:45 Pop Quiz of the Day3:48 Non-Alcoholic Alternatives4:33 Kava & Kratom4:59 The emotional benefits of alcohol7:18 STUDY: Alcohol & Amygdala8:04 Hannah Went's Bio9:38 Welcome Hannah!10:38 How do Epigenetics affect Healthspan15:30 Steve Horvath & Biological Age17:24 Dr. Morgan Levine & 2nd Generation Clocks18:58 Is Telomere testing still valuable?22:04 Senolytics for Senescent Cells25:07 NEW STUDY: Predicting Age in Women28:30 Measuring Spermidine levels28:25 Epigenetic vs Blood/Serum Testing30:33 Spermidine, NMN, NR & Rapamycin33:55 Caloric Restriction & Dunedin PACE35:20 *Magnesium Breakthrough*37:30 The nuances of fasting/feeding39:28 Stress, thoughts & mindset on Aging40:20 3rd Generation Clock: Dunedin PACE44:35 The “Rejuvenation Olympics”45:50 Pregnancy, Illness & Surgeries47:01 How else can we slow the aging process?48:28 Effect of green space on aging50:04 How detrimental is alcohol?55:24 Sleep deprivation & age57:24 Transgenerational Epigenetic Inheritance59:52 Are we all doomed?1:02:35 How can we be more pro-active?1:03:22 Lab Grown Meat1:07:21 Her final piece of advice1:07:55 Where to find more of her!1:08:19 Thanks for tuning in!RESOURCES:Website: Everything EpigeneticsWebsite: TruDiagnosticIG: Everything Epigenetics Email: hannah@everythingepigenetics.comMagnesium Breakthrough - code: BIOHACKERBABES10Support this podcast at — https://redcircle.com/biohacker-babes-podcast/donationsAdvertising Inquiries: https://redcircle.com/brands

Research suggests that only 10-30% of our lifespan is determined by our genetics. This means that the vast majority of how we age is directly related to choices we make everyday - how and what we eat, exercise and sleep quality, to name a few. Dr Morgan Levine, Head of the Ageing in Living Systems Lab at Yale University, joins the podcast to share her insights into the cutting-edge developments in the science of aging and longevity. Learn more about your ad choices. Visit megaphone.fm/adchoices

GET TRANSCRIPT AND FULL SHOWNOTES: melanieavalon.com/morganlevine 2:00 - IF Biohackers: Intermittent Fasting + Real Foods + Life: Join Melanie's Facebook Group At Facebook.com/groups/paleoOMAD For A Weekly Episode GIVEAWAY, And To Discuss And Learn About All Things Biohacking! All Conversations Welcome! 2:15 - Follow Melanie On Instagram To See The Latest Moments, Products, And #AllTheThings! @MelanieAvalon 3:00 - AVALONX MAGNESIUM 8: Get Melanie's Broad Spectrum Complex Featuring 8 Forms Of Magnesium, To Support Stress, Muscle Recovery, Cardiovascular Health, GI Motility, Blood Sugar Control, Mood, Sleep, And More! Tested For Purity & Potency. No Toxic Fillers. Glass Bottle.  AvalonX Supplements Are Free Of Toxic Fillers And Common Allergens (Including Wheat, Rice, Gluten, Dairy, Shellfish, Nuts, Soy, Eggs, And Yeast), Tested To Be Free Of Heavy Metals And Mold, And Triple Tested For Purity And Potency. Get On The Email List To Stay Up To Date With All The Special Offers And News About Melanie's New Supplements At avalonx.us/emaillist! Get 10% Off avalonx.us And mdlogichealth.com With The Code MelanieAvalon Text AVALONX To 877-861-8318 For A One Time 20% Off Code for avalonx.us 6:20 - FOOD SENSE GUIDE: Get Melanie's App At Melanieavalon.com/foodsenseguide To Tackle Your Food Sensitivities! Food Sense Includes A Searchable Catalogue Of 300+ Foods, Revealing Their Gluten, FODMAP, Lectin, Histamine, Amine, Glutamate, Oxalate, Salicylate, Sulfite, And Thiol Status. Food Sense Also Includes Compound Overviews, Reactions To Look For, Lists Of Foods High And Low In Them, The Ability To Create Your Own Personal Lists, And More! 7:00 - BEAUTYCOUNTER: Non-Toxic Beauty Products Tested For Heavy Metals, Which Support Skin Health And Look Amazing! Shop At beautycounter.com/melanieavalon For Something Magical! For Exclusive Offers And Discounts, And More On The Science Of Skincare, Get On Melanie's Private Beautycounter Email List At Melanieavalon.Com/Cleanbeauty Or Text BEAUTYCOUNTER To 877-861-8318! Find Your Perfect Beautycounter Products With Melanie's Quiz: melanieavalon.com/beautycounterquiz 11:00 - Morgan's Background 14:15 - Why Do We Age? 16:30 - Aging In The Animal Kingdom 18:15 - Child Bearing And Longevity 20:00 - Communal Child Rearing 21:45 - The Biological Drive To Continue The Species 23:05 - Cancer Immortality 25:00 - Senescent Cells 27:45 - Biological Aging 29:00 - What Is Aging? 30:35 - BLISSY: Get Cooling, Comfortable, Sustainable Silk Pillowcases To Revolutionize Your Sleep, Skin, And Hair! Once You Get Silk Pillowcases, You Will Never Look Back! Get Blissy In Tons Of Colors, And Risk-Free For 60 Nights, At Blissy.Com/Melanieavalon, With The Code Melanieavalon For 30% Off! 34:00 - FEALS: Feals Makes CBD Oil Which Satisfies ALL Of Melanie's Stringent Criteria - It's Premium, Full Spectrum, Organic, Tested, Pure CBD In MCT Oil! It's Delivered Directly To Your Doorstep. CBD Supports The Body's Natural Cannabinoid System, And Can Address An Array Of Issues, From Sleep To Stress To Chronic Pain, And More! Go To feals.com/melanieavalon To Become A Member And Get 40% Off Your First 3 Months, With Free Shipping! 36:45 - Where Does The Aging Process Start? 39:30 - Comorbidities With Age 41:00 - Super-Centennarians 42:25 - Can We Edit Our Genes To Live Longer? 45:30 - Phenotypes Of Aging 50:20 - Defining Biological Age 51:20 - Are We Aging Faster Than Before? 53:30 - Disease Processes 55:00 - When Does Aging Actually Start 56:30 - Measuring Biological Age 58:00 - DNA Methylation 59:30 - The 9 Biomarkers To Tell Your Biological Age 1:02:25 - Historical Data Of Chronic Diseases 1:05:30 - Methylation Status As Compared To Health 1:06:50 - Epigenetic Clocks 1:10:00 - BEAUTY AND THE BROTH: Support Your Health With Delicious USDA Organic Beauty & The Broth Bone Broth! It's Shelf Stable With No Preservatives, And No Salt Added. Choose Grass Fed, Grass Finished Beef, Or Free Range, Anti-Biotic And Hormone Free Range, Antibiotic And Hormone-Free Chicken, Or Their NEW Organic Vegan Mushroom Broth Concentrate Shipped Straight To Your Door! The Concentrated Packets Are 8x Stronger Than Any Cup Of Broth: Simply Reconstitute With 8 Ounces Of Hot Water. They're Convenient To Take Anywhere On The Go, Especially Travel! Go To melanieavalon.com/broth To Get 15% Off Any Order With The Code MelanieAvalon! 1:14:10 - Can We Change Our Methylation? 1:17:35 - Yamanaka Factors 1:20:10 - Can We Make Changes To Our Yamanaka Factors? 1:23:25 - Can Our Genome Age Backwards? 1:24:50 - Testing Yamanaka Factors 1:26:15 - What Is The Most Practical In Anti-Aging? 1:27:35 - Plasma Exchange 1:31:35 - Rapamyicin 1:32:20 - Morgan's Practical Implimentations 1:33:50 - How Fast Can We See Changes If We Change Our Lifestyles? 1:36:30 - Consumer Products For Testing Inner Age 1:37:20 - NR And NMN 1:38:15 - The Future Of Anti-Aging 1:41:30 - How Intuitive Are We? 1:45:10 - Guessing Ages

@michaelsalzle. Exercise, sleep, and future innovations in the field of aging (CR mimetics, senolytics, young blood, and yamamaka factors)

@michaelsalzle. IGF, protein restriction, FMD, TRE, 5:2 and ADF

@michaelsalzle. The benefits of calorie restriction and slowing our biological age

If someone asks you how old you are, you'll probably answer with the number that reflects the birth date on your driver's license. But scientists are learning that chronological age is not the same as your biological age. Technology has given researchers the tools to measure countless metrics and cross-reference them to get a better picture of your true age. One of those researchers is Morgan Levine. This week, on Big Books and Bold Ideas, she spoke with host Kerri Miller about how your biological age can give you a glimpse into the future, but one that you have the power to alter. “Your biological age on any given day is not your destiny,” she writes in her new book, “True Age: Cutting-Edge Research to Help Turn Back the Clock.” Guest: Morgan Levine is a aging researcher, an adjunct professor of pathology at Yale and the founding investigator at Altos Labs, a biotech firm that aims to develop life extension therapies. Her new book is “True Age: Cutting-Edge Research to Help Turn Back the Clock.” To listen to the full conversation you can use the audio player above. Subscribe to the MPR News with Kerri Miller podcast on Apple Podcasts, Google Podcasts or RSS. Subscribe to the Thread newsletter for the latest book and author news and must-read recommendations. 

What could our future be like if we could significantly slow down aging?Morgan Levine is a ladder-rank Assistant Professor in the Department of Pathology at the Yale School of Medicine and a member of both the Yale Combined Program in Computational Biology and Bioinformatics and the Yale Center for Research on Aging. ‍In this episode of the Existential Hope podcast, Morgan speaks on what she thinks the future of aging will look like, and what her hopes are. Full transcript, list of resources, and art piece: Morgan Levine | On the Future of Aging (existentialhope.com)Existential Hope was created to collect positive and possible scenarios for the future so that we can have more people commit to the creation of a brighter future, and start mapping out the main developments and challenges that need to be navigated to reach it. Find all previous podcast episodes here.The Foresight Institute is a research organization and non-profit that supports the beneficial development of high-impact technologies. Since our founding in 1987 with a vision of guiding powerful technologies, we have continued to evolve into a many-armed organization that focuses on several fields of science and technology that are too ambitious for legacy institutions to support.Allison Duettmann is the president and CEO of Foresight Institute. She directs the Intelligent Cooperation, Molecular Machines, Biotech & Health Extension, Neurotech, and Space Programs, Fellowships, Prizes, and Tech Trees, and shares this work with the public. She founded Existentialhope.com, co-edited Superintelligence: Coordination & Strategy co-authored Gaming the Future, and co-initiated The Longevity Prize. Beatrice Erkers is Chief of Operations at Foresight Institute and program manager of the Existential Hope group. She has a background in publishing and years of experience working with communication at Foresight and at a publishing house. Apply to Foresight's virtual salons and in-person workshops here!We are entirely funded by your donations. If you enjoy what we do please consider donating through our donation page.Visit our website for more content, or join us here:TwitterFacebookLinkedInEvery word ever spoken on this podcast is now AI-searchable using Fathom.fm, a search engine for podcasts. Hosted on Acast. See acast.com/privacy for more information.

How long do you want to live? How healthy do you want to be in your later years? For many podcast listeners, healthspan is more important than lifespan, but it's difficult to figure out what–if anything⁠–can stack the deck in your favor. On this week's podcast, we'll meet PhD researcher and author, Morgan Levine, who is actively working to answer these questions.  Listen and learn:  Why exercise is probably the greatest anti-aging tool Metformin and rapamycin: do they work? Human age potential Heritability vs. epigenetics  Links Morgan Levine's Book ABOUT OUR GUEST Morgan Levine was an Assistant Professor in the department of Pathology at Yale University. She now works with Altos Labs, where she leads a research group on bioinformatics, cellular biology, and biostatistics. She is the author of, True Age: Cutting-Edge Research to Help Turn Back the Clock. Like the Show? Leave us a review Check out our YouTube channel Visit www.yogabody.com

Dan Buettner's specialty is Blue Zones — communities where people live the longest, healthiest lives on the planet. He researched and wrote about these communities in his book, "The Blue Zones Solution.” He also helped create new Blue Zones in places like Iowa, New York and Minnesota. His work mirrors that of Yale researcher Morgan Levine. She studies aging and longevity, and she'll talk about the latest science with host Kerri Miller on this week's Big Books and Bold Ideas. Until then, be inspired by this 2015 discussion Miller had with Buettner at the Minneapolis Foundation's Face Forward Conference. Guest: Dan Buettner is an explorer, National Geographic Fellow, award-winning journalist andproducer, and New York Times bestselling author. He's written several books about Blue Zones. To listen to the full conversation you can use the audio player above. Subscribe to the MPR News with Kerri Miller podcast on Apple Podcasts, Google Podcasts or RSS. Subscribe to the Thread newsletter for the latest book and author news and must-read recommendations. 

How many times did your mother tell you not to swim for half an hour after you eat or not to scratch a bug bite or don't touch someone who has poison ivy because you can catch it? There is a lot of that summertime advice flying around. This episode begins by looking at whether this advice is true or not. https://www.silive.com/healthfit/2012/07/summer_myths_debunked.html There is something called toxic positivity. It is the idea that we should always look on the bright side, be happy, everything happens for a reason, don't worry, you'll be fine – you know what I mean. Often we say these things to comfort people but it may have the opposite effect. Joining me to discuss toxic positivity and the damage it can do is Whitney Goodman a licensed marriage and family therapist and author of the book, Toxic Positivity: Keeping It Real in a World Obsessed With Being Happy (https://amzn.to/3cwrhcf).  You have your chronological age and then there is your biological age. You can't do anything about your chronological age, but it does appear you can roll back the years on your biological age according to Morgan Levine. She is an assistant professor of pathology at Yale University School of Medicine and author of the book, True Age: Cutting-Edge Research to Help Turn Back the Clock (https://amzn.to/3zaRepw).. Listen as she reveals what to do to stay young for as long as possible. Smelling roses can have quite an impact on you and it is all good!. That scent can affect your memory, your dreams and your happiness. Listen as I explain. https://www.dailymail.co.uk/sciencetech/article-1059329/How-sweet-dreams--simply-smell-roses.html and https://www.nature.com/news/2007/070305/full/news070305-10.html PLEASE SUPPORT OUR SPONSORS! Factor makes it easy to eat clean 24/7, with fresh, delicious, prepared meals! Head to https://go.factor75.com/something120 & use promo code Something120 to get $120 off! Start hiring NOW with a $75 Sponsored Job Credit to upgrade your job post at https://Indeed.com/SOMETHING  Offer good for a limited time. Truebill is the smartest way to manage your finances. The average person saves $720 per year with Truebill. Get started today at https://Truebill.com/SYSK! See for yourself why teams at Airtable, Dropbox, HubSpot, Zendesk, and thousands of other companies use Zapier every day to automate their businesses! Try Zapier for free today at https://zapier.com/SYSK Go to https://Shopify.com/sysk for a FREE fourteen-day trial and get full access to Shopify's entire suite of features! Redeem your rewards for cash in any amount, at any time, with Discover Card! Learn more at https://Discover.com/RedeemRewards The magic is waiting! Download Harry Potter: Puzzles & Spells, for free, from the iOS App Store or Google Play today! Learn more about your ad choices. Visit podcastchoices.com/adchoices

As a longevity aficionado, I am so excited to be talking to Dr. Morgan Levine in this episode of New Frontiers! Renowned for her research on the science of biological aging, Dr. Levine specifically uses bioinformatics to quantify the aging process. She's played a vital role in developing and retraining several well-published bio age clocks, including the PhenoAge and Horvath clocks, making them much more reliable. Needless to say, I'm a big fan! Morgan and I dive into the fascinating science behind her new book, True Age: Cutting-Edge Research To Help Turn Back The Clock, and cover loads of important topics such as vetting bio age clocks, the role of the DNA methylome, how standard labs such as CBCs and CMPs can be used to calculate bio age, the controversial debate around immortality, challenges of applying the Yamanaka factors in clinical practice, how racial disparities affect biological aging – and believe me, so much more! I hope you'll enjoy this thrilling conversation as much as I did, and please give me your feedback wherever you listen to New Frontiers - DrKF

@michaelsalzle. Ways to measure your biological age

We go back to 1981 on the inflation flashback special of Game-Showey!  Would you want to know how long you could live for?  Dr. Morgan Levine, Assistant Professor Adjunct in Pathology at Yale University, gets into how scientists are learning how we age, how the perception of our age matters, and more. What is the most important thing Ukrainians are doing every day to survive Russias invasion? We get an update on the politics and day-to-day lives of Ukrainians from lawyer and advocate Stepan Berko, who is in Kyiv Plus, the work lawyers are trying to do to make real judicial change in the nation.   HEY, DO YOU LIKE PODCASTS? Why not subscribe to ours?find it on Apple, Google, Spotify & Curiouscast.ca   

We dive into the fascinating topics of longevity, healthspan and biological age this week with Dr. Morgan Levine. She explains the differences between healthspan & lifespan, as well as biological age & chronological age. She also shares the best testing options currently available to assess our biological age, along with what the research is showing makes the greatest impact such as fasting, caloric restriction, stress reduction and sleep.Morgan Levine is an assistant professor of pathology at Yale University School of Medicine. Her research focuses on the science of biological aging, specifically using bioinformatics to quantify the aging process and test how lifestyle and pharmaceutical interventions alter the rate of aging. As a leading voice in the field of aging and longevity science, she has been featured in media outlets such as CNN, The Guardian, Time, Newsweek, The Huffington Post, the BBC, and many more. She also appeared in the DocuSeries by Netflix and Goop, alongside Gwyneth Paltrow, which was released in early 2020. She is the author of True Age: Cutting-Edge Research to Help Turn Back the Clock.SHOW NOTES:0:54 Welcome to the show!5:01 Dr. Morgan Levine's Bio5:47 Welcome Dr. Levine6:56 Her definition: Healthspan vs Lifespan7:51 Her personal health goal8:37 How long can we live?9:19 Chronological & Biological age10:59 Testing options for biological age12:21 Renee's biological age tests16:08 DNA methylation & Epigenetics18:44 Her thoughts on telomeres & telomerase20:10 How can we motivate people?22:20 The role of genetics vs behavior23:13 The role of stress on aging24:38 Difference in longevity between men & women26:55 *Women's Healing Vacation Ad*28:49 Why do women have a longevity advantage?30:43 Really interesting animal studies!31:33 The Horvath Clock33:06 Senescence cells & the aging process35:13 Caloric restriction & fasting38:31 Dr. Levine as a biohacker39:55 Exercise for longevity412:01 How do you know what's working?42:53 Can genetics guide our exercise?44:11 *Othership breathwork app47:18 The importance of sleep quality & quantity49:12 ApoE gene & health risks53:35 “Ageotypes”58:12 Does social connection play a role?1:00:06 Her personal health choices1:01:17 The future of cellular reprogramming1:04:21 What are the best biomarkers to track?1:06:45 Her final piece of advice1:07:12 Thanks for tuning in! RESOURCES:Book: True AgeWebsite: morganlevinelab.comTwitter: https://twitter.com/DrMorganLevineInstagram: https://www.instagram.com/dr.morganlevine/Othership App - first two weeks free with LINKWOMEN'S BIOHACKING RETREATSupport this podcast at — https://redcircle.com/biohacker-babes-podcast/donations

@michaelsalzle. Biological age vs. chronological age, and the importance of making aging a disease. She also reviews the different hallmarks of aging

 In this episode of the Epigenetics Podcast, we caught up with Morgan Levine from Altos lab to talk about her work on Epigenetic Clocks and Biomarkers of Ageing. The Levine Lab focuses on deciphering mechanisms that lead to epigenetic ageing, which can be measured by epigenetic clocks. Epigenetic clocks were first described in 2011 by Bocklandt et al.. Later-on, the Horvath and the Hannum clock were described by using a combination of CpGs to calculate biological/epigenetic age in contrast to chronological age. The Levine Lab themselves worked on generating an advanced version of an Epigenetic clock, called "DNAm PhenoAge" that will now be used, and not only in human samples. The team now moves to mouse models and to cells in a dish and using those models to investigate the mechanisms behind epigenetic aging.   References Liu, Z., Leung, D., Thrush, K., Zhao, W., Ratliff, S., Tanaka, T., Schmitz, L. L., Smith, J. A., Ferrucci, L., & Levine, M. E. (2020). Underlying features of epigenetic aging clocks in vivo and in vitro. Aging cell, 19(10), e13229. https://doi.org/10.1111/acel.13229 Levine, M. E., Lu, A. T., Quach, A., Chen, B. H., Assimes, T. L., Bandinelli, S., Hou, L., Baccarelli, A. A., Stewart, J. D., Li, Y., Whitsel, E. A., Wilson, J. G., Reiner, A. P., Aviv, A., Lohman, K., Liu, Y., Ferrucci, L., & Horvath, S. (2018). An epigenetic biomarker of aging for lifespan and healthspan. Aging, 10(4), 573–591. https://doi.org/10.18632/aging.101414 Levine, M., McDevitt, R. A., Meer, M., Perdue, K., Di Francesco, A., Meade, T., Farrell, C., Thrush, K., Wang, M., Dunn, C., Pellegrini, M., de Cabo, R., & Ferrucci, L. (2020). A rat epigenetic clock recapitulates phenotypic aging and co-localizes with heterochromatin. eLife, 9, e59201. https://doi.org/10.7554/eLife.59201 Kuo, C. L., Pilling, L. C., Atkins, J. C., Masoli, J., Delgado, J., Tignanelli, C., Kuchel, G., Melzer, D., Beckman, K. B., & Levine, M. (2020). COVID-19 severity is predicted by earlier evidence of accelerated aging. medRxiv : the preprint server for health sciences, 2020.07.10.20147777. https://doi.org/10.1101/2020.07.10.20147777   Related Episodes Aging and Epigenetics (Peter Tessarz) Epigenetic Mechanisms of Aging and Longevity (Shelley Berger)   Contact Active Motif on Twitter Epigenetics Podcast on Twitter Active Motif on LinkedIn Active Motif on Facebook Email: podcast@activemotif.com

On today's Cool Science Radio, Lynn Ware Peek and John Well's guests include:(1:12) Dr. Atul Malhotra, a professor in the Department of Medicine at UC San Diego School of Medicine and Laurent Martinot, CEO and co-founder of Sunrise, have teamed up to revolutionize the way we detect sleep apnea and other sleeping challenges.Then (30:33), Dr. Morgan Levine, assistant professor of pathology at Yale University, who tackles the science of aging and longevity in her book, True Age: Cutting-Edge Research to Help Turn Back the Clock.

WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Skin Health & Healing: https://alituranaturals.com/shop/, use code DAVE20 for 20% off storewideDigestion & Immune Function: https://justthrivehealth.com, use code ASPREY to get 15% offBusiness Growth With SEO: https://www.stephanspencer.com, get a FREE consultationIN THIS EPISODE OF THE HUMAN UPGRADE™... …you'll learn how biological age, rather than chronological age, is the primary risk factor behind diseases like cancer, heart disease, diabetes, strokes, even Alzheimer's. Scientific discoveries show chronological aging may be written in the epigenome, those chemical tags attached to your DNA that control the way DNA operates.We're finding out more about both types of aging because of scientists like Morgan Levine, Ph.D., a leading voice in the field of aging and longevity science. She focuses her research on the science of biological aging, emphasizing health span over lifespan. “If you take the difference between someone's biological age and chronological age, it should predict the things we care about, the actual things we're trying to prevent—so death, disease,” she says. She's an assistant professor of pathology and the Director of the Laboratory for Aging in Living Systems at Yale University School of Medicine. Her team looks at using bioinformatics to quantify the aging process and test how lifestyle and pharmaceuticals alter the rate of aging. She's also a founding Principal Investigator at Altos Labs, a biotech company that focuses on cellular rejuvenation programming to restore cell health and resilience.Today, she's going to talk about the science of aging and longevity explored in her new book, “True Age: “Cutting-Edge Research to Help Turn Back the Clock.” Three main drivers—health behaviors, recent stressors and adversity, and genetics—determine your biological aging. She shares how to measure your own biological age and why you should track your aging regularly. This conversation gets into topics and makes them make sense for your own aging, like:Epigenetics & epigenetic clocksDNA methylation & telomeresCell lifespan Ageotypes (molecular assessment of aging)Phenotypic ageThe “Ceiling” effectThe “CALERIE” trialNutrition & aging (plants, fasting, ketosis)Fitness & aging (energy & brain health)Rest & relaxation (sleep & biological programming)Morgan gives great takeaways on how you can make lifestyle changes to maintain your youthfulness—both inside and out—with low-risk, data-driven biohacking. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

To celebrate the 50th episode of the Know Your Physio podcast, Andrés Preschel takes the hot seat! His amazing partner, Parker Sloan Leiro, AKA “The Rolling Sloan” takes over to ask all the pressing questions. We hear all about KYP's goal to make science sexy and accessible, and the immense value that Andrés has gained from hosting the podcast. In this episode, we find out which episodes impacted Andrés most profoundly and the amount of work that goes in, behind the scenes. Andrés touches on topics of fear setting, slow productivity, and what drives motivation, sharing astute advice for those seeking success in a saturated field. Tune in to find out where the goal to improve listeners' overall health literacy is leading Andrés in his personal and professional life, as he shares his infectious passion for scientific self-discovery.Key Points From This Episode:The benefits of BiOptimization's new Magnesium Breakthrough supplement.What inspired Andrés to start the podcast!The unexpected growth and success of the podcast.Andrés recounts the KYP episode with early podcast guest, Romero Britto.What he admires most about Romero Britto.Which guests and episodes have affected Andrés' life most profoundly.What he has learned through hosting the podcast.Andrés breaks down the work and intentions of the KYP brand and company.The work Andrés puts in behind the scenes.What drives motivation.What fear setting is and why Andrés pursues discomfort.Parkinson's disease simply explained.How Andrés has remained present through the exponential growth of his personal brand.The importance of pacing yourself as you work towards long-term goals.Andrés' advice for those seeking success in a saturated field.The concept of slow productivity. Andrés' favorite episodes so far and what's in store for the future!The immense value Andrés has gained from podcasting.Why Andrés and Parker are moving!Stay tuned for the KYP newsletter.Links Mentioned in Today's Episode:BiOptimizersParker Sloan Leiro on InstagramRomero BrittoDr. Morgan Levine on InstagramFrank Llosa on LinkedInKetoneAidCal Newport on Slow ProductivityThe Huberman Lab Podcast: The Science of Setting & Achieving GoalsKnow Your Physio Episode 016: Patrick PorterAnthony BenedettiniAndrés PreschelKnow Your Physio PodcastSupport the show

Dr. Morgan Levine is a Professor in the Department of Pathology at the Yale School of Medicine and a member of both the Yale Combined Program in Computational Biology and Bioinformatics, and the Yale Center for Research on Aging. Thank you to our sponsors, 10% off with promo code ( justin10 ) https://nootopia.com/justin?v=5&gl=6257021a8ebf58ab357b23c6 Connect With Morgan  https://medicine.yale.edu/profile/morgan_levine/ https://www.morganlevinelab.com/ https://www.instagram.com/dr.morganlevine/?hl=en https://twitter.com/DrMorganLevine?ref_src=twsrc%5Egoogle%7Ctwcamp%5Eserp%7Ctwgr%5Eauthor

This week I start talking about The UK government's, rather shameful, decision to delay the ban on multi-buy deals of shitty food (and related advertising). And this leads me to the subject of personal responsibility for your own health; YOUR choices are the things that affect YOUR health the most. I quote from Dr Morgan Levine, a scientist at Yale, in the above bit. You can read a Guardian interview with her hereAnd, of course, as a parent; your choices also have abig impact on your child's happiness and well-being. So what simple things can you do to make sure you are doing the best you can any given day and help your child be as healthy as they can be.In the news this week; I also talk about a study I came across that shows that taking Ibuprofen, and other anti-inflammatory drugs, may INCREASE the chances of chronic pain. So be careful with that stuff!! The same does NOT go for paracetamol, aspirin etc. so you seem to be better off taking that. Remember to follow us on Instagram and Facebook for the competitions, wisdom and cute videos. And, of course, you can always find us on our YouTube channel if you like your podcast in video form with little pictures :) Visit healthypostnatalbody.com and get 3 months completely FREE access. No sales, no commitment, no BS. Email peter@healthypostnatalbody.com if you have any questions or comments Playing us out this week;  So Tell Me by EILOH

Dr. Morgan Levine is currently the Assistant Professor of Pathology and Epidemiology at the Yale University School of Medicine and runs the University's Aging Living Systems Lab. She is one of the leading experts on the Science of biological aging, specifically using bioinformatics to quantify the aging process. A leading voice in the field of aging and longevity science, she is joining this week fresh off the launch of her first book “True Age: Cutting Edge Research to Help Turn back the clock”.    In today's episode Dr. Levine provides her point of view on the many definitions of aging. Explains the difference between biological and chronological aging and discusses the importance of tracking your biological age over time. Provides an overview of the biological age testing methods on the market today.  Lists some of the most damaging agents and activities that can expedite aging? Discusses how we might impact our biological age and how some are already turning back the clock. Lastly, whether or not there is a limit on human lifespan.   Mentioned in Today's Show:  Dr. Lavine's New Book: True Age: Cutting-Edge Research to Help Turn Back the Clock Dr. Valter Longo's Prolon Fast Mimicking Diet - https://prolonfmd.sjv.io/KeGnk9 Elysium Health - Biological Age Test - https://www.elysiumhealth.com/products/index   Follow Dr. Morgan Levine:  Laboratory for Aging in LIving Systems - https://www.morganlevinelab.com/ Instagram: @dr.morganlevine   For Our Listeners: Hyperice 10% discount for our listeners - https://bit.ly/3IalDa1 Libsyn use promo code “KEN” for 2 months FREE - https://bit.ly/3tNkpxC    Follow The Professional Athlete Podcast with Ken Gunter: Instagram: @kengunter_tpa Website: https://www.kengunter.com/ YouTube: Ken Gunter https://www.youtube.com/channel/UCRhgjkoSiJXAbS_MIasvvzQ/ Facebook: https://www.facebook.com/kengunterpodcast Audio recorded with SquadCast: https://squadcast.fm/?ref=kengunter Audio Produced By: Justin Gunter Show Produced By: Ken Gunter, Justin Gunter Content Designer: Austin Suit Music: “Up and Down” by Patrick Sweany

Jill Schlesinger on the sinking stock markets/ pulling back on spending // Paging Dr. Cohen -- cruise safety and mask fitting // Hanna Scott rounding up local criminal sentencings // Dose of Kindness -- repaying kindness with money for cancer treatments // Gee Scott on vacation wardrobes and impulses // Dr. Morgan Levine, author of True Age See omnystudio.com/listener for privacy information.

We all have friends, family, or classmates that just seem to be aging much slower than we are. In her book, True Age, Dr. Morgan Levine explores what we can do to slow our body's aging process to look and feel younger than our chronological age. You can find the full show notes for this episode at 40plusfitnesspodcast.com/536.

The definitive guide to you and your age, showing you how to live your best life healthy and happy. Research suggests that only 10-30 per cent of our lifespan is determined by our genetics. This means that the vast majority of how we age is directly related to choices we make everyday—how and what we eat, exercise and sleep quality, to name a few. So, while ageing itself may be inevitable, what if there were a way to measure our biological age? And what if there were strategies to slow down, or even reverse, the ageing process? In True Age, Dr Morgan Levine gives us an insight into the cutting-edge developments in the science of ageing and longevity and teaches us that through understanding our biological age, we can monitor and even control the process of ageing. True Age explores: The concept of biological age and the methods now available to determine your own. Types of foods likely to decrease our biological age—and which will age you prematurely. What types of exercise are most effective for turning back the clock. How much sleep we need and what other lifestyle patterns are most likely to help slow and reverse ageing. True Age will equip you with the tools you need to develop personal regimes, diets and routines specifically tailored to keep you looking—and feeling—as young as possible. Using her years of expert research in the field, Dr Levine will put you on the path to living a healthier and more proactive life.

Morgan Levine, Ph.D., developed the phenotypic aging clock called PhenoAge and is a Founding Principal Investigator at Altos Labs, a biotech company that seeks to understand the mechanisms that drive the aging process and age-related diseases with the hope of identifying possible interventions. Additionally, Dr. Levine is an assistant professor of pathology at the Yale University School of Medicine, where her research focuses on the science of biological aging. Dr. Levine completed a postdoctoral fellowship with previous guest Dr. Steve Horvath, a pioneer in the field of epigenetic clocks.  In this episode, Dr. Levine and I discuss:  00:01:19 - What is aging and why does it matter to scientists? 00:04:45 - Hallmarks of aging 00:08:59 - The advantage of epigenetic clocks in research 00:19:05 - Epigenetic age acceleration 00:36:40 - Are epigenetic changes in aging a cause or consequence? 00:42:15 - Reversing epigenetic age with interrupted reprogramming techniques 00:49:27 - Therapeutic plasma exchange in aging and pro-aging factors in blood  00:56:01 - Lifestyle factors that accelerate epigenetic age 01:03:23 - Reliability of consumer epigenetic aging tests 01:06:12 - Construct validity of epigenetic clocks 01:12:06 - Thoughts on most exciting research in aging field  01:13:44 - Dr. Levine's lifestyle habits Get the show notes: foundmyfitness.com/episodes/morgan-levine Looking for more? Join over 300,000 people and get the latest distilled information on sleep, depression, and fasting straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Try thirty days of our FoundMyFitness premium member to get access to exclusive episodes, emails, a live Q+A with Rhonda and more: https://www.foundmyfitness.com/trial

Today's guest is Dr. Morgan Levine, an assistant professor of Pathology and Epidemiology at Yale School of Medicine. She is also a Founding Principal Investigator at Altos, a new biotechnology company focused on cellular rejuvenation programming to restore cell health and resilience. Dr. Levine shares her expertise on biological aging, aging clocks, cellular reprogramming, and a peek into the research she's currently undertaking at Altos here today. She starts the conversation by explaining the differences between biological aging and chronological aging. She then delves into topics surrounding biological clocks such as DNA methylation, and discusses her work at Altos and how this will differ from an academic environment.  Dr. Levine finishes up by highlighting what Altos hopes to bring to science and biotech in years to come. In today's episode, you'll learn the difference between biological and chronological aging, the nature of biological clocks, and some of the exciting work taking place in biotechnology these days. Episode Highlights: The difference between chronological aging and biological aging What is an epigenome? How DNA methylation is measured Using aging clocks for a particular demographics How to decide if a discovery slows the biological clock Applications of clocks as it pertains to aging and longevity The costs of individual measurements Dr. Morgan's work at Altos How Altos was founded Deciding the direction of research Understanding cellular reprogramming The future at Altos Quotes: “Age measured in chronological time was the biggest risk factor for most diseases.” “I like to think of the epigenome as almost the operating system of a cell.” “The things that we assume should affect aging, in potentially an animal model, show effects when using the epigenetic clock.” “We've actually taken the human epigenetic clock and broken them out into.. what we would call different modules.”  “If we're measuring biological age, it should first correlate with chronological age to some degree, but not perfectly.” “We've become much more interested in understanding the clocks rather than developing new clocks… What's driving the changes that are captured by the clocks, and how do those link to the outcomes they're associated with?” “My lab is really a combination of both experimental wet lab people and computational dry lab people.” “I think  saying we just work on aging, or just work on longevity, is really constraining us to some degree.” Links: Email questions, comments, and feedback to podcast@bioagelabs.com Translating Aging on Twitter:https://twitter.com/BioAgePodcast ( @bioagepodcast) BIOAGE Labs Websitehttps://bioagelabs.com/ ( BIOAGELabs.com) BIOAGE Labs Twitterhttps://twitter.com/bioagelabs?lang=en ( @bioagelabs) BIOAGE Labshttps://www.linkedin.com/company/bioage-labs/ ( LinkedIn) Dr. Morgan'shttps://www.linkedin.com/in/morgan-levine-aa957463/ ( LinkedIn) Altos Labshttps://altoslabs.com/ ( Website)

VitaDAO Discussion Panel - On the quest to quantify biological age Host: Max Unfried Speakers: Dr. Morgan Levine, Nikolina Lauc, Dr. Joris Deleen

The final 2021 episode of the Live Longer World podcast is a rather special one. I've compiled some of the best & most informative parts of each of my previous episodes and highlighted them in this finale episode. Think of it as a tour showcasing some of the work being done in the field of longevity. Some topics included in the clips are Inflammaging, SystemsAge Clock, Reprogramming, Atherosclerosis, Brain Aging and more. And if a particular topic or clip captures your attention, you can of course go and watch the entire podcast episode. Hope you enjoy it and wishing everyone a happy & healthy holiday season! Episode Show Notes: https://livelongerworld.substack.com/p/2021 Find the previous podcast episodes: https://www.livelongerworld.com/podcast 2021 Live Longer World podcast episodes: #01: Reason, founder & CEO of Repair Biotechnologies #02: Dr. Jean Hebert on Tissue Replacement in the Brain #03: Carolina Oliveira, the founder & CEO of OneSkin #04: Dave Gobel, founder & CEO of Methuselah Foundation #05: Dr. Matt Kaeberlein on Aging Interventions, Rapamycin, mTOR #06: Dr. Morgan Levine on Epigenetic Clocks, SystemsAge Clock FOLLOW LIVE LONGER WORLD: Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/livelongerworld Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/longevityfuture/ Podcast All Platforms: https://anchor.fm/livelongerworld Patreon: https://www.patreon.com/livelongerworld YouTube: https://www.youtube.com/c/LiveLongerWorld Apple Podcasts: https://podcasts.apple.com/us/podcast/live-longer-world/id1588806541 Spotify: https://open.spotify.com/show/2Zc65BZb02msGuF9ujBThC

Panel Discussion about The Language of Communicating Longevity Hosted by VitaDAO & The Future of Longevity Speakers: Matt Kaeberlein, Morgan Levine, Karl Pfledger, Joao Pedro Magalhaes, Nathan Cheng, Laura Minquini, Max Unfried, Ariella Coler-Reilly, Avi Roy VitaDAO is the world's first decentralized intellectual property collective, funding and commissioning research into human longevity

Dr. Morgan Levine is an Assistant Professor of Pathology and Epidemiology at the Yale School of Medicine. Morgan runs the lab for Aging in Living Systems at Yale. Her labs works on Epigenetic Clocks, Epigenetic reprogramming, cellular aging trajectories, and in trying to understand the causes of Alzheimer's disease. I can't even begin to tell you how much I learned in today's conversation! We extensively discussed Morgan's work on developing a new Epigenetic clock called the SystemsAge clock, which is very cool and can test the biological age of different organs & systems in your body. We also spoke of different features of these clocks, interventions tested, what we know so far on reversing your biological age, some of the limitations of the clocks, why she is so excited about epigenetic reprogramming, and some of her work around Alzheimer's disease. Most people are interested in knowing their biological age and epigenetic clocks are a way to test it. So I'm sure you will find this conversation on epigenetic clocks fascinating and walk away understanding them much better! I hope you enjoy my conversation with Dr. Morgan Levine. Show notes + Timestamps: https://livelongerworld.substack.com/p/mlevine FOLLOW DR. MORGAN LEVINE: Morgan's Lab: https://www.morganlevinelab.com/ Twitter: https://twitter.com/DrMorganLevine FOLLOW LIVE LONGER WORLD: Website: https://www.livelongerworld.com/ Newsletter: https://livelongerworld.substack.com/ Twitter: https://twitter.com/livelongerworld Patreon: https://www.patreon.com/livelongerworld Instagram: https://www.instagram.com/longevityfuture Apple Podcasts: https://podcasts.apple.com/us/podcast/live-longer-world/id1588806541 Spotify: https://open.spotify.com/show/2Zc65BZb02msGuF9ujBThC

Dr. Morgan Levine, PhD (https://www.morganlevinelab.com/) is Assistant Professor of Pathology and Epidemiology, at the Yale School of Medicine. Dr. Levine is also a member of both the Yale Combined Program in Computational Biology and Bioinformatics, and the Yale Center for Research on Aging. Her work relies on an interdisciplinary approach, integrating theories and methods from statistical genetics, computational biology, and mathematical demography to develop biomarkers of aging for humans and animal models using high-dimensional -omics data. As PI or co-Investigator on multiple NIH-, Foundation-, and University-funded projects, she has extensive experience using systems-level and machine learning approaches to track epigenetic, transcriptomic, and proteomic changes with aging and incorporate this information to develop measures of risk stratification for major chronic diseases, such as cancer and Alzheimer's disease. Dr. Levine's work also involves development of systems-level outcome measures of aging, aimed at facilitating evaluation for gero-protective interventions. A number of the existing biological aging measures she has developed are being applied in both basic and observational research.

Today I'm speaking with Morgan Levine. Morgan is an assistant professor at Yale's Pathology department and runs a lab that aims to discover both the mechanisms that drive aging and interventions to slow or reverse that process. The lab also develops tools to measure biological age, which we will get into in our discussion of epigenetic clocks. Aging has long been assumed to be our insurmountable human fate. But as research of the past years has uncovered aging's malleability in some model organisms, the hope to slow or reverse the aging process in humans has become an increasingly attractive goal. And given that age is the greatest risk factor for developing many of the most common lethal diseases today, longevity research could potentially be extremely impactful both for prolonged health- and lifespans. Morgan and I don't go super deep into the science as I try to get a broad overview of the field and some of its structural challenges—but you can learn more about epigenetic clocks in the show notes linked below. => Shownotes

“For me being able to quantify aging is one of the most important endeavours in the field. There is a lot of emphasis on intervening in aging, to either reverse or slow it, but I would argue that there's no way to test if you did that if you can't directly measure the thing that you're trying to intervene in.”In this session, Morgan Levine, Assistant Professor at Yale, gave a sneak peek into the new epigenetic clock they are developing that is able to probe into multiple organ systems, as well as a new approach how to calculate clocks that is much more reliable, enabling to generate insights from methylation clocks with much smaller samples required. The second talk was given by Jamie Justice, Assistant Professor at Wake Forest, that covered the current ways and strides the longevity field is making towards validating biomarkers of aging through clinical trials, showing on examples of a few senolytic trials they made. In the end, she also explained how exactly the TAME trial, which she is a coordinator of, should serve as a vehicle for the field to move further and have a flagship trial to validate new aging biomarkers against in the future.Session summary: Biomarker Standardization | Morgan Levine, Yale, Jamie Justice, Wake Forest School of Medicine - Foresight InstituteThe Foresight Institute is a research organization and non-profit that supports the beneficial development of high-impact technologies. Since our founding in 1987 on a vision of guiding powerful technologies, we have continued to evolve into a many-armed organization that focuses on several fields of science and technology that are too ambitious for legacy institutions to support.Allison Duettmann is the president and CEO of Foresight Institute. She directs the Intelligent Cooperation, Molecular Machines, Biotech & Health Extension, Neurotech, and Space Programs, Fellowships, Prizes, and Tech Trees, and shares this work with the public. She founded Existentialhope.com, co-edited Superintelligence: Coordination & Strategy, co-authored Gaming the Future, and co-initiated The Longevity Prize. Apply to Foresight's virtual salons and in-person workshops here!We are entirely funded by your donations. If you enjoy what we do please consider donating through our donation page.Visit our website for more content, or join us here:TwitterFacebookLinkedInEvery word ever spoken on this podcast is now AI-searchable using Fathom.fm, a search engine for podcasts.  Hosted on Acast. See acast.com/privacy for more information.

We are all used to feeling younger than our years and occasionally older than our birth date would suggest.  In effect, we have two ages - chronological and biological. Chronological age simply states the number of years that we have been alive, whereas biological age is a measure of how well our bodies are performing, in relation to the rest of the population.  So how is it determined?  LLAMA host Peter Bowes delved into the science with Elysium Health, which has developed Index, a DNA test that tracks how fast we have been aging, based on our epigenome, which regulates the way genes work.  In this episode, Peter meets Dr. Morgan Levine, an assistant professor of pathology at Yale School of Medicine and an advisor to Elysium Health. They discuss the background to Index, its use of epigenetic clocks to put a number to our biological age, as well as the test's accuracy and implications for healthy living. Recorded: April 21, 2021 | Read a transcript and show notes at the LLAMA podcast website. Topics covered in this interview include:Defining biological age and chronological age. Age as a risk factor for death and diseaseHaving an older parent and developing an interest in aging A lack of consensus over what exactly is meant by aging.How much of aging can be defined as damage to the body, at a cellular level, as we grow older?How do we measure biological age?  Genes, genomes and the epigenome.Developing systems that determine biological age based on epigenetic clocks.Exploring the Index epigenetic, at-home saliva test, to determine biological age.    Privacy concerns related to sharing personal medical information.  Revealing Peter's biological versus chronological age. What does it mean? Interpreting the test results and taking action based on the findings.Does the test reveal information specific to potential medical conditions?How do doctors - primary care physicians - respond to the information gleaned from such tests? The paradigm shift from disease treatment to interventions that delay illness. Lifestyle interventions that promote a long, healthy life.  The reliability of biological age tests. Do repeat tests over a short space of time generate the same results? To what extent do results vary between young and older people? Lifespan and healthspan aspirations. Disclosure: For review purposes, Elysium Health provided Peter Bowes with an Index test kit, free of charge .This episode is brought to you in association with Clinique La Prairie, the award-winning spa-clinic and pioneering health and wellness destination - nestled on the shores of Lake Geneva in Montreux, Switzerland. Combining preventative medicine with bespoke lifestyle and nutrition plans, Clinique La Prairie offers a holistic approach to living fuller, healthier and longer lives.The Live Long and Master Aging podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.