Podcasts about ampk

Dr. Corey Schuler, PhD(c), FNP, DC, CNS, and director of medical affairs at Allergy Research Group, details his paper “Energy Allocation Resilience and Endocrine Integration” in the International Journal of Molecular Sciences. He introduces the Energy Allocation System (EAS), which emphasizes how the body allocates energy—not just produces it—and links many symptoms to impaired bioenergetics and resilience. They discuss mitochondria as energy generators and cellular signaling hubs, the integrated stress response and endocrine coordination (HPA axis, thyroid, gonads), and mitohormesis/eustress (exercise, fasting, heat/cold, circadian “zeitgebers”). Schuler explains nuanced testing for fatigue (diurnal cortisol, CGM patterns, thyroid markers including T3/reverse T3) and a case of a perimenopausal woman where oral contraceptives and cortisol dysregulation affected glucose patterns. They cover mitochondrial support (removing obstacles like pollutants/antibiotics, triglycerides, carnitine, dietary fats, micronutrients) and pacing/sequencing lifestyle interventions.

What if your skin could literally rebuild itself from the inside out? In this episode, we break down one of the most powerful and misunderstood biological processes in the human body: autophagy.From its Nobel Prize-winning discovery to the molecular machinery that drives it, we walk you through exactly what autophagy is, how it works at the cellular level, and why it matters far more than most people realize for skin aging.We explore the two master switches that control autophagy, mTOR and AMPK, and how the constant tug of war between them determines whether your cells are in build mode or cleanup mode. We also explain why most people in the modern world are stuck in permanent mTOR activation, and what that means for how their skin ages over time.This is Part 1 of our deep dive. In Part 2, we go skin-specific and break down exactly how autophagy renews your skin at the tissue level.What's Discussed:(0:19) The "phoenix process": the cellular mechanism rebuilding your skin from the inside out(3:14) What autophagy actually means, and why the science world ignored it for 30 years(4:47) How baker's yeast cracked the code that won the 2016 Nobel Prize(7:14) Inside a single skin cell: the step-by-step breakdown of how autophagy actually works(10:22) Why autophagy is not destruction, and what this means for your collagen supplements(16:44) The two master switches controlling whether your cells build or clean(20:10) The everyday habit silencing your body's most powerful anti-aging system(26:17) Why aging skin isn't broken, it has just never been told to cleanResources Mentioned:Biohacking Beauty Podcast: Ben Azadi: Why 93% of Americans Are Aging Too Fast + What to Do About It: podcasts.apple.com/us/podcast/ben-azadiFind more from Young Goose:Use code PODCAST10 to get 10% OFF your first purchase, and if you're a returning customer use the code PODCAST5 to get 5% OFF at younggoose.comInstagram: @young_goose_skincare

Chronic stress belly fat is more than a feeling — it changes your hormones, metabolism, and cravings. Nurse Doza breaks down 5 specific mechanisms — cortisol, insulin resistance, leptin dysfunction, fatty liver, and late-night eating — explaining exactly why belly fat won't budge and what to do about it. FEATURED PRODUCT:  The Metabolic Pack from MSW Nutrition is the complete protocol for everything covered in this episode. Liver Boost combines turmeric (curcumin), green tea extract (EGCG), NAC, and alpha-lipoic acid to reduce inflammation, support liver detoxification, and combat insulin resistance at the cellular level. Mitochondriac delivers resveratrol and key mitochondrial support to activate AMPK, improve cellular energy, and lower inflammatory markers linked to chronic stress and weight gain. Zen contains an adaptogenic blend with Rhodiola, Ginseng, Eleuthero, Schisandra, and bovine adrenal glandular support — specifically designed to regulate cortisol and protect adrenal health. Together, these three supplements form a 60–90 day metabolic reset built to address the root causes of chronic stress belly fat.

Chronic stress belly fat is more than a feeling — it changes your hormones, metabolism, and cravings. Nurse Doza breaks down 5 specific mechanisms — cortisol, insulin resistance, leptin dysfunction, fatty liver, and late-night eating — explaining exactly why belly fat won't budge and what to do about it. FEATURED PRODUCT:  The Metabolic Pack from MSW Nutrition is the complete protocol for everything covered in this episode. Liver Boost combines turmeric (curcumin), green tea extract (EGCG), NAC, and alpha-lipoic acid to reduce inflammation, support liver detoxification, and combat insulin resistance at the cellular level. Mitochondriac delivers resveratrol and key mitochondrial support to activate AMPK, improve cellular energy, and lower inflammatory markers linked to chronic stress and weight gain. Zen contains an adaptogenic blend with Rhodiola, Ginseng, Eleuthero, Schisandra, and bovine adrenal glandular support — specifically designed to regulate cortisol and protect adrenal health. Together, these three supplements form a 60–90 day metabolic reset built to address the root causes of chronic stress belly fat.

In this episode, Dr. Jockers breaks down the science of autophagy and mTOR, two crucial processes for cellular repair and growth. Learn how balancing these pathways is key to slowing down aging and optimizing longevity. Discover the powerful impact of fasting, exercise, and ketosis on activating autophagy and inhibiting mTOR. Dr. Jockers explains how these strategies help reduce inflammation and promote healthy muscle mass. You'll also hear about the best foods and supplements to support your body's natural healing processes. From polyphenols to intermittent fasting, this episode gives you the tools to boost cellular regeneration and maintain vitality. In This Episode:  00:00 Autophagy Basics 00:23 Podcast Intro and Resources 03:28 mTOR Explained 04:21 Autophagy and AMPK 05:11 Longevity Risks and Balance 07:10 How to Inhibit mTOR 08:55 What Increases mTOR 12:21 Exercise Spring Load Strategy 13:22 Fasting Window and Meals 16:17 Longevity Takeaways and Outro   Unwind with Purality Health's KSM 66 Ashwagandha, clinically proven to reduce stress and improve overall health. Its advanced nano-absorption technology ensures you get this ancient herb's full benefits. Experience better sleep, enhanced memory, and a calmer mindset. Enjoy a special buy one, get one free offer now! Each order comes with a six-month satisfaction guarantee. Visit longevityroot.com/drj to claim your deal and start feeling less stressed today. Say goodbye to unhealthy cooking oils and elevate your meals with Kettle & Fire's 100% grass-fed beef tallow. Free from seed oils and preservatives, it's the cleanest, healthiest fat you can use for cooking. With a high smoke point of 420°F, it's perfect for grilling, roasting, and sautéing, bringing both great flavor and nutritional benefits. For a limited time, enjoy 25% off sitewide with the code DRJOCKERS at checkout. Visit kettleandfire.com/drjockers to shop now!   "Autophagy clears out what's broken so your body can rebuild stronger, cleaner, and more efficient cells." ~ Dr. Jockers   Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean TuneIn Radio     Resources: Visit renewyourhair.com/drj to claim your exclusive offer Visit kettleandfire.com/doctorjockers with the code DRJOCKERS   Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https:/www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/   If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/ 

Your cells start failing at 35. Dr Sandra Kaufmann reveals the 7 systems breaking down — and how to stop it. Your cells start failing at 35. Dr Sandra Kaufmann reveals the 7 systems breaking down — and how to stop it.

Your day is getting programmed whether you choose it or not, and the “golden hours” after waking and before sleep are where that programming sticks. I walk through what's happening in the brain and nervous system during those windows, why we're more suggestible and neuroplastic, and how a few small choices can shift your baseline from reactive to regulated. If your mornings start with scrolling, stress, and quick dopamine hits, you may be teaching your body to crave agitation, distraction, and tunnel vision all day long.I share my flexible, repeatable morning routine built around spirit, mind, and body: meditation done out of bed, intention setting that acts like a GPS for your subconscious, and gratitude to create heart-brain coherence. We also talk about discipline versus willpower, how to create natural dopamine through learning, and how movement and breathwork help clear cortisol so you can think bigger, feel steadier, and respond instead of react. These are practical nervous system regulation tools you can adapt to any season of life.Then we pivot to a topic I'm seeing everywhere: protein. Can you overdo it? Absolutely. I explain why protein can still drive insulin, how excess can spill over into glucose production and fat storage, and which symptoms can signal “too much” for your body, from digestion and dehydration to sleep disruption and hot flashes. We zoom out into pathways, not just macros, comparing mTOR and IGF-1 growth signaling with AMPK, ketosis, and autophagy so you can balance building muscle with cellular repair, metabolic health, and long-term longevity.If you're ready to stop copying influencers and start listening to your biofeedback, press play, then subscribe, and share this with a friend who's stuck in health noise!To work one-on-one with me, you can apply HERE!To get notified as soon as groups open up and other updates sign up/subscribe here:https://stacy-baker.mykajabi.com/opt-in-9cffc5f4-f006-4adb-a0a7-6c33a0698b4bResources mentioned:Ketone and Blood Sugar Testing MasterclassKetone TestingRa Optics (Code DRSTACYND) blue light blockersHigher Dose (my FAV sauna blanket with low to no EMF) code DRSTACYCGM *2 months free with code DRSTACYStructured/Living Water *code DRSTACYSpring Aqua (my FAV water system) For more from me, follow me on IG @dr.stacy.ndEpisodes Mentioned: Dairy Paradox/Insulin Impact Calorie Deficit versus FastingThank you for listening! This information is just that; information only - not to be taken as medical advice. Please contact your primary care before changing anything to your routine. This information is not mean to diagnose, treat, or cure disease.

¿Es la Leucina el suplemento "mágico" para ganar masa muscular? En este video, el Profe Claudio Nieto te explica qué es este aminoácido esencial, cómo activa la ruta mTOR (el interruptor del anabolismo) y por qué más no siempre es mejor. NUEVA SERIE SOBRE SUPLEMENTOS aquí https://www.youtube.com/playlist?list=PL9Ipv-hDntXB3tHKCGvsTav0SfOxB0rOv Analizamos el famoso "umbral de leucina" y resolvemos la duda definitiva: ¿Es necesario suplementarse si ya tomas proteína de suero o llevas una dieta alta en proteínas? Descubre por qué este "delantero pichichi" necesita a todo el equipo de aminoácidos para funcionar y en qué casos específicos (lesiones, edad avanzada o dietas veganas) sí puede marcar la diferencia. Aprende fisiología de forma sencilla para que lo complejo se entienda fácil y te sirva en tu día a día. Episodio patrocinado por BeLevels, suplementos desarrollados junto al Dr. Antonio Hernández. Fórmulas limpias, científicas y efectivas para optimizar tu salud, rendimiento y longevidad. Usa el código PROFECLAUDIO y obtén un DESCUENTO además de ayudar al canal a seguir creciendo. LINK: https://belevels.com/collections/todos-los-productos-belevels?sca_ref=9626651.hWyXCkDKIZ&utm_source=uppromote&utm_medium=affiliation&utm_campaign=newcustomer En este video aprenderás: Qué es la leucina y por qué es un aminoácido ramificado (BCAA) clave. La diferencia entre las vías metabólicas mTOR (anabolismo) y AMPK (catabolismo). El umbral de leucina: ¿Cuántos gramos necesitas realmente? ¿Por qué los BCAAs podrían "entorpecer" la absorción de la leucina aislada? Casos prácticos: Cuándo usarla como "parche" útil en tu nutrición. #Leucina #SuplementosDeportivos #MasaMuscular #Fisiología #NutriciónDeportiva #ProfeClaudioNieto #mTOR #Proteína _________________________________ Suscríbete para más fisiología aplicada al rendimiento y la salud: https://www.youtube.com/channel/UCBPNMoFXj3c7N7WWSbSsxlg?sub_confirmation=1 Sígueme en Instagram: https://www.instagram.com/profeclaudionieto/ Web oficial: https://www.profeclaudionieto.com/ #fisiología #fisiologíadeportiva #nutricióndeportiva #rendimientodeportivo #saludmetabólica #suplementosdeportivos #entrenamiento #profeclaudionieto 00:00 ¿Qué es la Leucina y para qué sirve? 02:27 El "delantero pichichi" de los aminoácidos 03:10 Vías mTOR y AMPK: El equilibrio metabólico 05:10 ¿Cuándo necesitamos anabolismo? 06:42 El umbral de Leucina: Los gramos clave 07:31 Fuentes naturales vs Suplementos 09:25 ¿Leucina sola o con otros aminoácidos? 11:18 Por qué los BCAAs pueden competir entre sí 14:06 ¿Realmente aumenta la masa muscular? (La verdad) 16:09 Casos donde la suplementación tiene sentido 18:58 El error de los deportistas post-entreno 20:28 Efectos adversos y dosis razonables 21:20 Resumen final y conclusiones

Most of the NAD+ skincare on shelves right now is built on a misunderstanding. And if you've been trusting niacinamide to do the heavy lifting, this episode is going to change how you read a label.This episode is Part 2 of our NAD+ deep dive. Here, we get into what actually works to raise NAD+ in the skin, the real precursors, the delivery technology that gets them where they need to go, and the mitochondrial support system most brands leave out. We also walk through the lifestyle levers that move the needle, and why one of them becomes non-negotiable for women after a certain age.If Part 1 explains what steals your NAD+, this episode is where the science gets practical and eye-opening.What's Discussed:(5:07) What the clinical data actually says about topical niacinamide(7:21) Why most niacinamide products on your shelf are underdosed(8:16) The roundabout pathway that makes niacinamide a poor NAD+ precursor(9:03) Niacinamide is a brightening agent, not an NAD+ booster(10:15) Why NMN can't cross the skin barrier alone(11:19) CD38 and blocking the enzyme that destroys NAD+(13:03) NAD+ alone is potential energy, not usable energy(13:45) Liposomal encapsulation and how real precursors get into the skin(17:02) The five mitochondrial pathways your skin actually needs(18:53) Senescent cells and the next telomeres conversation(25:17) Why NAD Apex targets NAD+ in three dimensions(26:39) Lifestyle strategies: fasting and the AMPK pathway(28:47) How to get 30 to 50% more NAD+ from caloric restriction through fasting(30:37) The fun fact behind why 16:8 fasting became the standard(33:02) HIIT and its compounding effect on baseline NAD+(34:51) Sleep is an NAD+ dependent repair session, not just rest(39:15) Your skin does 8x more renewal at night(41:38) Sun protection as an NAD+ strategy(44:49) Why you should expose your back more than your face(45:29) Contrast therapy, heat shock proteins, and cold-driven biogenesis(50:32) Why stacking NAD+ boosting activities at 50% beats maxing out one modality(52:49) The perimenopause problem no one is talking about(56:29) Why niacinamide creates homework for the body(1:01:46) You recycle more NAD+ daily than you can ever supplement(1:02:19) 5-Amino-1MQ, the peptide that recycles NAD+(1:05:35) Mitophagy, autophagy, and the role of spermidine(1:06:44) Ergothioneine, the only antioxidant with a direct mitochondrial transporter(1:07:46) Fermented resveratrol and activating SIRT1Check out resources mentioned:Part 1 of our NAD+ deep dive: The NAD+ Thief Your Skin Can't Escape: CD38, Zombie Cells, and the DeclineCheck out our NAD+ Guide: NAD+ & SKIN AGING - The Cellular Energy ConnectionSleep is Skincare episode: How Timing Unlocks Your Body's Best Skincare RepairFind more from Young Goose:Use code PODCAST10 to get 10% OFF your first purchase, and if you're a returning customer use the code PODCAST5 to get 5% OFF at https://younggoose.comInstagram: @young_goose_skincareVampire Exosomes: Professional Exosome Serum for Regeneration and Post-Treatment Recovery https://younggoose.com/products/vampire-exosomes

Cancer has long been understood through a variety of biological frameworks, including genetic mutations, dysregulated signaling pathways, and uncontrolled cell proliferation. Yet, these models often capture the visible consequences of disease rather than the deeper metabolic dependencies that sustain tumor survival. Despite major advances in targeted therapies, a central challenge remains: what underlying mechanisms make cancer cells vulnerable to treatment, and how can these vulnerabilities be exploited more effectively? Increasing attention has shifted toward cellular metabolism—particularly lipid regulation and energy-sensing pathways such as AMPK—as critical determinants of tumor behavior. Scientists are now taking a closer look at how metabolism works together with stress responses like autophagy—and how this connection could be used to develop better cancer treatments. A new research paper was published in Volume 17 of Oncotarget, titled “The SCD1 inhibitor aramchol interacts with regorafenib and metformin to kill tumor cells.” The study was led by first author Michael R. Booth and corresponding author Paul Dent from Virginia Commonwealth University, in collaboration with Laurence Booth and Jane L. Roberts from Virginia Commonwealth University and John M. Kirkwood from the University of Pittsburgh Cancer Institute. Full blog - https://www.oncotarget.org/2026/04/21/scd1-inhibition-strategy-shows-potent-synergy-with-regorafenib-and-metformin-in-tumor-cell-killing/ Paper DOI - https://doi.org/10.18632/oncotarget.28861 Correspondence to - Paul Dent - paul.dent@vcuhealth.org Abstract video - https://www.youtube.com/watch?v=lmX_c2e_-HY Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28861 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, macroautophagy, ER stress, aramchol, regorafenib, BID To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

Fatty liver and insulin resistance form a dangerous loop driving diabetes, dementia, and colon cancer. Learn what causes this cycle, what happens when it keeps running, and how diet, fasting, the Mediterranean diet, and targeted supplements can break it for good. FEATURED PRODUCT The Good Poops Protocol — combining Liver Boost, Gut Powder, and Berberine Plus — directly targets both sides of the fatty liver and insulin resistance loop discussed in this episode. Liver Boost supports your liver's ability to process fats and manage detoxification, Berberine Plus has been shown to improve insulin sensitivity and lower pro-inflammatory cytokines, and Gut Powder addresses the digestive consequences — bloating, constipation, and gut dysfunction — that compound when this loop goes unchecked. Together, these three work on the liver, the blood sugar, and the gut simultaneously, which is exactly what this episode makes clear you need.

Walking videos are everywhere — "walk 10,000 steps and melt belly fat." The conclusion is right: walking does reduce body fat. But the explanation is completely wrong. Your body compensates for ~80% of exercise calories. The real reason walking transforms metabolic health has almost nothing to do with calories burned. Here's the actual science. CHAPTERS: 0:00 - The walking myth: why calorie counting is wrong 0:52 - I'm Dr. Robert Lufkin — the actual mechanism 1:09 - Part 1: The calorie burn myth 1:24 - Pontzer's constrained energy model (Current Biology, 2016) 2:12 - Your body claws back 80% of exercise calories 2:51 - Constrained energy expenditure confirmed (2021 review) 3:36 - The body's compensation is actually the feature 3:42 - Part 2: The hormonal truth — insulin and GLUT4 4:05 - GLUT4: 100-fold glucose uptake without insulin 4:49 - AMPK: the molecular switch for fat oxidation 5:31 - AMPK activates autophagy via sestrins 6:05 - Part 3: Cortisol and visceral fat 6:18 - Visceral fat: the fat that kills 7:07 - Walking lowers cortisol (systematic review) 7:37 - Outdoor walking: 20–30 min for biggest cortisol drop 7:45 - Japanese walking study: visceral fat down, independent of calories 8:18 - Part 4: The post-meal walk 8:52 - 10-minute walk right after eating beats 30 minutes later 9:44 - Why the body's calorie compensation is a metabolic gift 10:36 - Part 5: The metabolic framework 11:04 - Walking is a hormonal intervention, not a calorie one 12:01 - Walking: 2 million years of metabolic medicine REFERENCES: Constrained Total Energy Expenditure (Pontzer et al., Current Biology, 2016): https://pubmed.ncbi.nlm.nih.gov/26832439/ 10-Min Walk Immediately After Meals Suppresses Glucose (Hashimoto et al., Scientific Reports, 2025): https://pubmed.ncbi.nlm.nih.gov/40594496/ Exercise, GLUT4, and Skeletal Muscle Glucose Uptake (Physiol Rev, 2013): https://pubmed.ncbi.nlm.nih.gov/23899560/ GLUT4 Translocation — 100-Fold Glucose Uptake (Am J Physiol, 2020): https://pmc.ncbi.nlm.nih.gov/articles/PMC8260367/ AMPK and Adaptation to Exercise (Annual Review of Physiology, 2022): https://pmc.ncbi.nlm.nih.gov/articles/PMC8919726/ Physical Activity Lowers Cortisol (Psychoneuroendocrinology, 2022): https://pubmed.ncbi.nlm.nih.gov/35777076/ Walking + Forest Environment Reduces Cortisol (Frontiers in Public Health, 2019): https://pmc.ncbi.nlm.nih.gov/articles/PMC6920124/ Daily WalkiNew episodes every Tuesday & Thursday. Subscribe so you don't miss one.Continue this conversation on Substack: https://robertlufkinmd.substack.comLies I Taught In Medical School — Free sample chapter: https://www.robertlufkinmd.com/lies/Web: https://www.robertlufkinmd.comYouTube: https://www.youtube.com/robertlufkinmdX: https://x.com/robertlufkinmdInstagram: https://www.instagram.com/robertlufkinmd/TikTok: https://www.tiktok.com/@robertlufkinLinkedIn: https://www.linkedin.com/in/robertlufkinmd/

If you feel like your metabolism has slowed down, your workouts aren't working, and your body isn't responding the way it used to… this episode explains why. In Part 3 of this series, we shift from identifying the problem to understanding the solution. Because your metabolism isn't broken. Your signals are disrupted. After years of chronic stress, underfueling, overtraining, poor recovery, and hormonal shifts in midlife, the body adapts by slowing down, conserving energy, and prioritizing survival over performance. In this episode, you'll learn how to restore the signals that control your metabolism—from the inside out. We break down: • Why energy availability is the foundation of metabolic recovery • The balance between AMPK (burn mode) and mTOR (build mode) • How nervous system regulation impacts fat loss, hormones, and recovery • Why breathing patterns and carbon dioxide tolerance affect energy production • The role of gut health, liver detox pathways, and inflammation in metabolism • How receptor sensitivity impacts hormone function and results • What true metabolic resilience looks like in midlife This is where you stop forcing your body… …and start rebuilding it. If you're ready to understand your metabolism on a deeper level and create a personalized strategy based on your data, this is exactly what we do inside The FutureYou Blueprint.

Are you great at burning fat—but struggling with recovery, muscle, energy, or stubborn body composition? In this Part 1 episode, Coach Debbie Potts takes you down a deep-dive rabbit hole into AMPK dominance, the "burn mode" many high performers and endurance athletes unknowingly live in. You'll learn how chronic stress, under-fueling, fasting, and excessive endurance training can shift your body into energy conservation instead of rebuilding—and why this becomes even more important in midlife. Debbie breaks down the difference between being a fat burner vs. metabolically flexible, and how PNOĒ metabolism testing reveals key clues at rest (RMR) and during exercise (AMR), including: • Low resting metabolic rate (RMR) and what it really means • Fat-burning dominance vs true metabolic flexibility • Poor high-intensity capacity and "flat" performance • Limited carbohydrate access when you need it most • Signs of chronic AMPK activation and reduced mTOR signaling This episode will help you understand why your body may feel stuck—even when you're doing everything "right"—and why the solution isn't more discipline, but better metabolic signaling and strategy. This is where you stop guessing… and start connecting the clues.

This week's stories: *SNL Roasts the MAHA Movement Saturday Night Live took direct aim at RFK-adjacent anti-vaccine culture in a sketch that lampoons raw milk, bull semen, energy healers, and "natural immunity" rhetoric — and it landed with a mainstream audience. Dave breaks down what it means when fringe health narratives become national punchlines, and why being a biohacker means staying precise about what you're actually skeptical of. Sources: -https://www.nbc.com/saturday-night-live -https://www.statnews.com/2026/03/03/fda-breakthrough-designation-generative-ai-chatbot-recovryai/ *Pistachios Are a Stealth Longevity Stack New Cornell-linked research shows pistachios are significantly more bioactive than standard nutrition data suggested — hitting Nrf2, AMPK, and gut barrier pathways simultaneously. This is a whole-food hack hiding in plain sight. Sources: -https://www.reddit.com/r/Biohackers/comments/1rvcqiy/cornell_university_reveals_pistachios_are_far/ -https://www.instagram.com/p/DViqesBDOZQ/ *40 Million People Are Using ChatGPT as Their Doctor Industry estimates put daily ChatGPT health queries at roughly 40 million users — making AI the largest informal primary care interface on the planet. Dave lays out the only safe framework for using these tools without getting burned. Sources: -https://www.linkedin.com/pulse/month-healthcare-ai-march-2026-gary-monk-ermcf -https://www.statnews.com/2026/03/03/fda-breakthrough-designation-generative-ai-chatbot-recovryai/ -https://bipartisanpolicy.org/issue-brief/fda-oversight-understanding-the-regulation-of-health-ai-tools/ *Your Microbiome Is a City — and Architecture Matters New biofilm research shows that how your gut microbes physically organize themselves may matter as much as which strains you have. The next frontier of microbiome hacking is infrastructure, not species. Sources: -https://phys.org/news/2026-01-hidden-microbial-communities-health-space.html -https://astrobiology.com/2026/03/rethinking-the-microbial-future-of-space-travel.html *Colon Cancer Is Now the Leading Cause of Cancer Death Under 50 This is no longer a retirement problem. Dave breaks down the four drivers behind the spike — and why your gut health protocols are now frontline cancer prevention. Sources: -https://pubmed.ncbi.nlm.nih.gov/41754195/ -https://www.washingtonpost.com/wellness/2026/03/03/muscle-strength-longevity-study/ *Measles Is Back — and the Math Is Unambiguous Over 1,300 confirmed cases across 31 states in 2026 alone, with the US at risk of losing its measles elimination status for the first time since 2000. Dave addresses the "natural immunity" argument directly — and doesn't pull punches. Sources: -https://www.cdc.gov/measles/cases-outbreaks.html -https://bipartisanpolicy.org/issue-brief/fda-oversight-understanding-the-regulation-of-health-ai-tools/ This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on immune resilience, gut health, microbiome optimization, cancer prevention, and how to use AI tools safely. Host Dave Asprey connects emerging science, cultural shifts, and real epidemiological data into practical frameworks you can use to build a resilient, adaptable health stack. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: MAHA movement biohacking, SNL vaccine sketch, RFK health satire, pistachios polyphenols longevity, pistachio Nrf2 AMPK, ChatGPT health advice AI, AI primary care risks, gut microbiome biofilm architecture, colon cancer under 50, colorectal cancer young adults, colon cancer prevention diet, measles outbreak 2026, measles elimination status, natural immunity measles risk, immune amnesia measles, biohacking news, longevity research 2026 Thank you to our sponsors! - Dave Asprey's 2026 Clean Nicotine Roadmap | Enroll for free at: daveasprey.com/2026-clean-nicotine-roadmap- The One Device | Use code DAVE for $10 off at theonedevice.com/dave Resources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 00:41 – SNL Roasts the MAHA Movement 03:20 – Pistachios and Longevity 04:37 – AI as Your Health Advisor 06:12 – Gut Biofilms and Microbiome Architecture 07:44 – Colon Cancer in Young People 09:23 – The Measles Comeback See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Biomechanist Katy Bowman and biologist Dr. Jeannette Loram explain how just nine minutes of vigorous activity can make a measurable difference for your cardiovascular health. They break down what counts as vigorous exercise, how to gauge it “old skool” without complicated gadgets, and how much is needed based on the movement patterns of the heart-healthy Hadza. Plus, they share nine practical ways to fit short bursts of higher-intensity movement into your day, from running stairs and kitchen dance parties to treading water in a pool.The episode also explores a personal experience related to the menopause transition, including the onset of salt sensitivity, water retention, and hypertension. Katy and Jeannette discuss the link between estrogen and salt management, explaining why the loss of estrogen can make women more susceptible to salt-induced high blood pressure—and what lifestyle shifts can help protect heart health.Enhanced Show Notes and Full Transcript00:00 — Introduction & Sponsors01:50 — Heart Health and Midlife Movement03:45 — What Counts as Vigorous Exercise?07:00 — How Much Vigorous Do We Actually Need? Insights from the Hadza 12:30 — Nine Minutes of Vigorous Movement: Practical Ideas to fit into your life25:00 — Listener Question: Vigorous Movement in the Pool36:20 — Warming Up for Vigorous Movement Snacks 41:30 — Salt Sensitivity, Menopause & Blood PressureLinks & Research Mentioned:Physical Activity Patterns and Biomarkers of Cardiovascular Disease Risk in Hunter Gatherers  by Raichlen et al (2017) Lifestyle and Patterns of Physical Activity in Hadza Foragers by Sayre et al (2023)Association of wearable device-measured vigorous intermittent lifestyle physical activity with mortality by Stamatakis et al (2022) Postmenopausal Salt Sensitivity and Hypertension by Kim et al (2014)Estrogen negatively regulates the renal epithelial sodium channel (ENaC) by promoting Derlin-1 expression and AMPK activation by Zhang et al (2019) Salt Sensitivity of Blood Pressure in Women by Barris et al (2023)Connect, Move & Learn:Join Our Newsletter: Movement Colored GlassesFollow Katy on SubstackTry Katy's Virtual Studio Free for 7 days!Made Possible By Our Wonderful Sponsors:Movemate: Active standing boards with smoothly articulating wooden slats. Designed to keep you moving without interrupting your focus.Peluva: Five-toe minimalist shoes that move like you do—take 10% off with code NUTRITIOUSMOVEMENTMy Happy Feet: Toe-spacing socks that gently realign toes for comfortable recovery—take 20% off with code MYDNA.Venn Design: Beautifully upholstered ball-shaped Air Chairs that encourage dynamic sitting.Ikaria Design: The Soul Seat® offers height-adjustable, multi-position sitting—get 10% off new chairs and desks with code DNA10.Smart Playrooms: Beautiful playroom design and movement-rich equipment—save 10% on monkey bars and rock-wall items with code DNA10.Thoughts/questions email us at podcast@nutritiousmovement.comYour Voice on the Podcast: Read The Credits 

Longevity science is shifting fast. New discoveries are revealing that aging may be influenced not just by genetics or lifestyle, but by specific nutrients that regulate cellular health. In this episode of Habits & Hustle, I sit down with Dr. Stephanie Venn-Watson to explore the discovery of C15, a fatty acid that emerged from decades of research studying Navy dolphins. Her work suggests that declining C15 levels may weaken cell membranes, accelerate aging, and increase vulnerability to metabolic disease. We break down how this molecule works, why not all saturated fats are the same, and how modern dietary shifts away from full-fat dairy may be contributing to widespread nutrient deficiencies. We also discuss how C15 interacts with longevity pathways like AMPK and mTOR, the same pathways targeted by drugs like metformin and rapamycin, and why researchers believe C15 may function as a geroprotector — a compound capable of slowing biological aging. Dr. Stephanie Venn-Watson is a veterinary epidemiologist, CEO of Seraphina Therapeutics, and author of The Longevity Nutrient. Her work bridges marine biology, epidemiology, and human longevity science to uncover how nutrition influences cellular aging. What's Discussed (07:48) How studying Navy dolphins led to a breakthrough in longevity research (10:31) Why dolphins are a powerful model for studying human aging (16:04) The discovery of C15 and its role in metabolic health (17:33) Why not all saturated fats are harmful (20:25) How C15 interacts with longevity pathways like mTOR and AMPK (22:23) How modern diets may be creating a widespread C15 deficiency (24:30) The link between C15 deficiency and accelerated cellular aging (27:11) How dairy fat became the primary source of C15 in humans (31:18) Why C15 may qualify as a “geroprotector” (34:28) How to measure C15 levels through blood testing (39:23) Signs of cellular fragility and biological aging in blood markers (43:02) How C15 may influence inflammation and autoimmune conditions (50:20) The lifestyle factors that matter most for longevity (55:17) Other ways to increase C15 levels through diet and exercise Thank you to our sponsors: Rho Nutrition: Try Rho Nutrition today and experience the difference of Liposomal Technology. Use code JEN20 for 20% OFF everything at https://rhonutrition.com/discount/jen20  Prolon: Get 30% off sitewide plus a $40 bonus gift when you subscribe to their 5-Day Program! Just visit https://prolonlife.com/JENNIFERCOHEN and use code JENNIFERCOHEN to claim your discount and your bonus gift. Therasage: Head over to therasage.com and use code Be Bold for 15% off  Air Doctor: Go to airdoctorpro.com and use promo code HUSTLE40 for up to $300 off and a 3-year warranty on air purifiers. Magic Mind: Head over to www.magicmind.com/jen and use code Jen at checkout. Momentous: Shop this link and use code Jen for 20% off  Manna Vitality: Visit mannavitality.com and use code JENNIFER20 for 20% off your order  Amp fit is the perfect balance of tech and training, designed for people who do it all and still want to feel strong doing it. Check it out at joinamp.com/jen   Find more from Jen:  Website: https://jennifercohen.com Instagram: @therealjencohen Books: https://jennifercohen.com/books Speaking: https://jennifercohen.com/speaking-engagement Find more from Stephanie Venn-Watson: Website: https://fatty15.com Instagram: https://www.instagram.com/fatty15/?hl=it  LinkedIn: https://www.linkedin.com/in/stephanievennwatson/ Book: The Longevity Nutrient

Is fasting actually worth it for fat loss, muscle retention, and longevity? In this science-backed breakdown, I explain intermittent fasting, autophagy, AMPK, mTOR, and whether fasting helps or hurts muscle growth. ► Free 7 Day Trial To My Workout App: https://www.liveleantv.com ► Live Lean Body Quiz: https://www.liveleantv.com/quiz ► Free 7 Day Meal Plan And Recipes: https://www.liveleantv.com/free-stuff

What should you actually do when you're chronically sleep deprived?If you're a parent, shift worker, insomniac, or coach people who are, you've probably asked yourself whether training is helping or harming you.In this episode, I dive into the research on acute and chronic sleep restriction and its effects on:• Cognitive performance• Strength and endurance• Hormonal signalling (testosterone, AMPK, mTOR)• Mood and perceived health• Recovery and long-term adaptationWe examine a 2025 systematic review and meta-analysis of 45 experimental studies (from 18,127 initially identified papers) looking at sleep deprivation and performance. We unpack one of the longest chronic sleep restriction protocols to date (6 weeks of restricted weekday sleep with weekend “recovery”), and what that tells us about cumulative sleep debt.We also explore:• Why early waking may impair cognition differently than going to bed late• Whether moderate aerobic exercise can offset some cognitive effects of sleep loss• What experimental data show about testosterone under sleep restriction• Why resistance training under chronic sleep deprivation may require adjustment• The difference between narrative reviews and higher-quality meta-analytic evidenceEssentially, we look at how to train intelligently when sleep is broken, short, or unpredictable, and what the science can (and cannot) tell us right now.Main ReferenceSystematic Review & Performance Effects[2025 Systematic Review & Meta-Analysis on Sleep Deprivation and Performance – 45 Experimental Studies]Chronic Sleep Restriction with Weekend RecoverySmith et al. (2021). Chronic sleep restriction during a 6-week protocol with weekend recovery and cumulative sleep debt analysis.

If you're over 45 and training consistently but noticing slower recovery, softer body composition, or declining strength — this episode is for you. In this deep-dive rabbit hole conversation, Debbie breaks down the real science of Muscle Protein Synthesis (MPS) and why protein distribution — not just total protein — becomes critical in midlife. You'll learn why 20–30 grams of protein often isn't enough anymore, why adults 45+ may need 3–4 grams of leucine per meal to fully activate mTOR signaling, and how anabolic resistance changes the muscle-building equation for both men and women. We also explore AMPK vs mTOR balance, chronic fasting and endurance training effects, insulin resistance, stress-driven cortisol interference, and how PNOĒ metabolic testing and genetic insights can personalize your muscle-building strategy. Midlife isn't decline — it's a threshold shift. When you understand the signaling, you can train smarter, fuel intentionally, and protect your metabolism for decades to come. Learn more about personalized testing and The FutureYou Blueprint™ at www.debbiepotts.net

Discover how fasting extends lifespan, lowers insulin and blood sugar, reduces inflammation, regenerates gut cells, and promotes autophagy. Learn the science-backed benefits of fasting and how to implement strategic fasting protocols for metabolic health, cellular repair, and longevity. Nurse Doza breaks down when and how to use fasting as a powerful health tool. FEATURED PRODUCT Mitochondriac, featuring resveratrol with quercetin and methylated forms, is designed to support mitochondrial function and mimic the beneficial effects of fasting. Research shows resveratrol activates the same pathways as fasting—AMPK, SIRT1, and PGC-1α—promoting autophagy, mitochondrial biogenesis, and cellular repair. Pairing Mitochondriac with your fasting protocol enhances the metabolic benefits discussed in this episode, making fasting more sustainable and effective for longevity and energy production.

Sardines are one of the most nutrient-dense, anti-inflammatory foods you can eat, but does eating only sardines actually count as fasting?     On today's show, I break down the growing trend of "sardine fasting," explain why it's gaining popularity, and clarify the key differences between true fasting, fasting-mimicking diets, and simply following a low-calorie, high-protein plan.     You'll learn why sardines, while incredibly healthy, do not lower IGF-1 or activate AMPK, why that matters for longevity and autophagy, and when a sardine-only day may—or may not—make sense depending on your goals.     Join me on today's Cabral Concept, Episode 3646, to find out whether the sardine fasting diet really works and what you can do instead to achieve better results.     Enjoy the show! - - - For Everything Mentioned In Today's Show: StephenCabral.com/3646 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

Why do we lose ourselves in love, repeat painful relationship patterns, and mistake intensity for intimacy instead of becoming whole within ourselves first?Josh Trent welcomes Sheleana Aiyana to the Wellness + Wisdom Podcast, episode 800, to explore why self-abandonment drives relationship chaos, how attachment wounds and the mother wound shape romantic bonds, what becoming the one truly means, how grief and motherhood catalyze deep healing, and why divine union begins with reclaiming self-trust, presence, and inner wholeness before partnership.In This Episode, Sheleana Aiyana Uncovers:(01:15) Why We Lose Ourselves In Relationships(06:40) Your Soul Came Here to Learn(11:10) Becoming The One(16:10) Awakening Through Relationships(20:50) Mother Wound(25:45) True Depth of Transformation + Healing(32:10) When Motherhood Reopens It Heals Your Wounds(38:55) What Is The Role of A Parent?(46:55) Life Feels Heavy When You Abandon Yourself(53:45) Relationship Rebirth(01:03:05) What Is A Divine Union?

Why do we lose ourselves in love, repeat painful relationship patterns, and mistake intensity for intimacy instead of becoming whole within ourselves first? Josh Trent welcomes Sheleana Aiyana to the Wellness + Wisdom Podcast, episode 800, to explore why self-abandonment drives relationship chaos, how attachment wounds and the mother wound shape romantic bonds, what becoming the one truly means, how grief and motherhood catalyze deep healing, and why divine union begins with reclaiming self-trust, presence, and inner wholeness before partnership.   About The Guest Sheleana Aiyana is the best-selling author of Becoming the One and the founder of Rising Woman, a global community dedicated to self-healing, relational transformation, and spiritual embodiment. Her work blends somatic awareness, inner child healing, and grounded spiritual insight to guide millions through the landscapes of heartbreak, love, and personal rebirth. Having grown up in foster care and overcome cycles of abuse, addiction, and heartbreak, Sheleana's teachings are not theoretical, they are lived. Through Rising Woman, she has helped millions remember that healing is not about becoming someone else, but about reclaiming the love, power, and wholeness that was always theirs.

Sardines are one of the most nutrient-dense, anti-inflammatory foods you can eat, but does eating only sardines actually count as fasting?     On today's show, I break down the growing trend of "sardine fasting," explain why it's gaining popularity, and clarify the key differences between true fasting, fasting-mimicking diets, and simply following a low-calorie, high-protein plan.     You'll learn why sardines, while incredibly healthy, do not lower IGF-1 or activate AMPK, why that matters for longevity and autophagy, and when a sardine-only day may—or may not—make sense depending on your goals.     Join me on today's Cabral Concept, Episode 3646, to find out whether the sardine fasting diet really works and what you can do instead to achieve better results.     Enjoy the show! - - - For Everything Mentioned In Today's Show: StephenCabral.com/3646 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

Pain that creeps in, brain fog that lingers, weight that resists every effort—what if the culprit isn't “just getting older,” but inflammaging? We sit down with Dr. Shivani Gupta, author of The Inflammation Code, to connect ancient Ayurvedic wisdom with modern science and map out a practical plan for cooling chronic inflammation. Instead of chasing symptoms, we focus on the terrain: circadian rhythm, gut health, stress load, and daily rituals that nudge the body back into repair mode.Shivani shares a refreshingly doable morning routine—intention setting, hydration, tongue scraping, and early sunlight—that anchors your clock and digestion. She then walks us through soothing evening practices like dry brushing, abhyanga oil massage, and mineral baths to move lymph, calm the nervous system, and deepen sleep. We explore the concept of “mental inflammation,” how chronic stress inflames the body, and why short decompression breaks plus adaptogens such as ashwagandha and shatavari help regulate mood and resilience.We also dive into the science of turmeric: how curcumin modulates NF-kB and TNF-alpha, supports the gut lining, affects AMPK and sirtuins, and promotes neurogenesis and mitochondrial health. You'll hear when food sources are enough, when supplements make sense, how to boost absorption with black pepper and healthy fats, and key safety notes for blood thinners and kidney stone risk. For midlife women, Shivani emphasizes sleep as the non-negotiable lever—assessing progesterone, using calming botanicals, and protecting the 10–2 overnight window where the body clears inflammation.If you're ready to replace quick fixes with smart rhythms, spice up your meals with potent anti-inflammatory allies, and finally feel your energy return, this conversation offers a clear roadmap. Subscribe, share with a friend who needs actionable hope, and leave a review telling us which ritual or spice you'll try first.https://fusionaryformulas.com/            (Use LUFKIN15 for 15% off)Continue this conversation on SubStack: https://robertlufkinmd.substack.com Lies I Taught In Medical School : Free sample chapter- https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (LUFKIN20 for 20% off) https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmd Instagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/TikTok: https://www.tiktok.com/@robertlufkinThreads: https://www.threads.net/@robertlufkinmdFacebook: https://www.facebook.com/robertlufkinmd Blu...

Tired of doing “everything right” and still feeling inflamed, foggy, and out of sync with your body? We dig into a clear, faith-forward plan to restore energy, steady hormones, and heal the gut using targeted, physician-grade supplements and practical daily habits. No fads. No hype. Just clean science, smart dosing, and tools you can actually stick with.We start by reframing the problem: modern food and stress deplete minerals, overwhelm the liver, and skew our fat balance. That's why stacked support works best. We unpack Hormone Tame as a five-in-one: activated B vitamins for methylation, mitochondrial nutrients for energy, and polyphenols that help metabolize estrogen so periods calm and mood steadies. Then we tackle the omega equation—why seed oils drive inflammation and how a high-purity omega-3, plus magnesium, can flip the script on aches, sleep, and resilience.From there, we build your gut plan. A medical-food style protein with L-glutamine soothes IBS and feeds the lining. Digestive Lift adds enzymes, gentle acid, and ox bile to prevent bloat and help you handle healthy fats. For microbiome balance, Biome Lift stabilizes daily while Spore Lift acts like a bouncer when SIBO or post-travel trouble hits. We also introduce a fiber you won't fear: a diverse prebiotic blend that increases short-chain fatty acids, nudges Akkermansia for metabolic health, and naturally boosts GLP-1 to curb cravings.Detox gets a reset with a true 3-2-1 approach—opening phase 3 and 2 before phase 1 so toxins exit rather than recirculate. Expect less bloat, brighter skin, and steadier energy when you rotate this seasonally and keep daily support with Slim Lift. If you're stepping down from GLP-1 meds or want a stimulant-free metabolism boost, MetaboLift pairs GLP-1 support with AMPK activation to quiet “food noise” and raise your burn without wrecking appetite or sleep.This is how faith, functional medicine, and simple choices meet: whole foods, better fats, prayer, rest, and supplements that respect how the body actually works. Subscribe, share with a friend who needs hope, and leave a review to help more women find real healing.✨ Join the EMPOWERED BY FAITH: 5 Days To A Lighter You Challenge!

Sardines are one of the most nutrient-dense, anti-inflammatory foods you can eat, but does eating only sardines actually count as fasting?     On today's show, I break down the growing trend of "sardine fasting," explain why it's gaining popularity, and clarify the key differences between true fasting, fasting-mimicking diets, and simply following a low-calorie, high-protein plan.     You'll learn why sardines, while incredibly healthy, do not lower IGF-1 or activate AMPK, why that matters for longevity and autophagy, and when a sardine-only day may—or may not—make sense depending on your goals.     Join me on today's Cabral Concept, Episode 3646, to find out whether the sardine fasting diet really works and what you can do instead to achieve better results.     Enjoy the show! - - - For Everything Mentioned In Today's Show: StephenCabral.com/3646 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

Send us a textThe AMP kinase pathway's role in cellular energy sensing, nutrient allocation, and its connections to health practices like fasting, exercise, and diet.TOPICS DISCUSSED:Cellular energy basics: ATP/ADP/AMP as energy currencies; AMP kinase activates on low ATP to conserve and redirect resources, like a budget manager.AMP kinase mechanics: Heterotrimeric enzyme phosphorylating 100+ substrates; localizes dynamically in cytosol, mitochondria, nucleus to integrate signals.Nutrient detection: Senses fatty acids in fasting/ketogenic states, boosting fat oxidation and mitochondria independent of energy drops.Fasting/exercise impacts: Elevate AMP kinase for mitophagy, better fuel switching; mimic historical scarcity absent under modern constant feeding.mTOR relationship: AMP kinase inhibits mTOR to stop growth in low energy states; feedback loop disrupted by abundance, promoting tissue buildup.Disease links: Low AMP kinase in obesity/diabetes reduces flexibility; activation prevents cancer but may aid tumor survival in therapy.Drugs/diets: Metformin and GLP-1s like Ozempic activate AMP kinase for glucose control/weight loss; ketogenic diets activate at intermediate levels for fat efficiency.ABOUT THE GUEST: Gregory Steinberg, PhD is a Professor of Medicine at McMaster University and co-directs the Centre for Metabolism, Obesity, and Diabetes Research, focusing on cellular energy sensors like AMP kinase.RELATED EPISODE:M&M 260 | Energy Resistance Principle in Life, Healing & Disease | Martin Picard & Nirosha MuruganSupport the showHealth Products by M&M Partners: SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code TRIKOMES for 20% off. Lumen device: Optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off. AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models. Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) For all the ways you can support my efforts

Today, I'm joined by the incredible Anthony Castore, a trailblazer who fuses elite strength coaching with deep cellular medicine. In our conversation, Anthony shares his journey from a young athlete determined to defy genetic odds to becoming an expert in both physical training and the nuanced science of peptides, mitochondria, and bioregulators.   Use code NAT10 for 10% off products at https://alchemiqlabs.com/   Episode Timestamps: Welcome and episode introduction ... 00:00:00 Anthony Castore's path from strength coaching to cellular medicine ... 00:05:55 Connecting strength training with cellular pathways (AMPK, mTOR) ... 00:12:27 Explaining and balancing AMPK and mTOR for performance ... 00:13:03 Training strategies: Metabolic, hypertrophy, and neural approaches ... 00:18:18 Building a solid foundation: Lifestyle, training, nutrition, peptides ... 00:23:04 Assessing recovery capacity and individualizing protocols ... 00:26:02 Mitochondrial fission, fusion, and targeted adaptation ... 00:29:57 Optimizing muscle gain and fat loss through calories and recovery ... 00:31:00 Differentiating bodybuilder vs. longevity approaches ... 00:34:44 Integrating peptides and support molecules into routines ... 00:40:44 Ketone esters and mitochondrial peptide interventions ... 00:41:20 Cautions on stacking and combining interventions ... 00:54:04 Lessons learned from overdoing interventions ... 01:05:02   Our Amazing Sponsors: Vitali - combines pharmaceutical-grade copper peptides with zero-age exosomes to support clearer cellular signaling and long-term skin resilience, working with your biology instead of forcing change. Visit VitaliSkincare.com and use code NAT20 for 20% off.   BEAM Minerals - Low energy often starts in the mitochondria. Support cellular energy with a bioavailable liquid mineral supplement — and get 20% off at beamminerals.com with code NAT20.   Complete Liver Complex by LVLUP Health - supports your liver's natural detox pathways so your body can reset after the holidays without suffering. Go to lvluphealth.com and use code NAT for 20% off.   Nat's Links:  YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

Join My Private Group: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://theaxioncollective.manus.space/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Email List: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://huntershealthhacks.beehiiv.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Get My Book On Amazon: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://a.co/d/avbaV48Download⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠The Peptide Cheat Sheet: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://peptidecheatsheet.carrd.co/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Download The Bioregulator Cheat Sheet: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://bioregulatorcheatsheet.carrd.co/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠1 On 1 Coaching Application: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://hunterwilliamscoaching.carrd.co/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Book A Call With Me: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://hunterwilliamscall.carrd.co/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Supplement Sources: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://hunterwilliamssupplements.carrd.co/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Amazon Storefront: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.amazon.com/shop/hunterwilliams/list/WE16G2223BXA?ref_=cm_sw_r_cp_ud_aipsflist_R7QWQC0P1RACB2ETY3DY⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Socials:Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/hunterwilliamscoaching/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Video Topic Request: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://hunterwilliamsvideotopic.carrd.co/⁠⁠⁠⁠Today's episode is all about Viagra, but not in the way most people think about it. We're talking sildenafil for longevity, healthspan, and performance. The “little blue pill” has a reputation as an erectile dysfunction drug, but when you actually look at the mechanism and the data, it's doing way more than that.I've been a proponent of low-dose Cialis for a long time, and I still am. But lately I've been experimenting with rotating between Cialis and Viagra because I notice I can build a tolerance to Cialis over time. It still works, but I don't feel the performance benefits as strongly unless I push the dose higher. What I've found is that going four weeks on low-dose Cialis, then four weeks on low-dose Viagra, seems to keep me more responsive overall while still giving me the benefits that matter for longevity.In this episode, I break down the real mechanism. Sildenafil is a PDE5 inhibitor that amplifies nitric oxide signaling and raises cGMP throughout the body. That means systemic vasodilation, improved endothelial function, better blood flow to organs, and anti-thrombotic effects through reduced platelet activation. And the downstream effects get even more interesting. We're talking mitochondrial signaling through PKG, potential ischemic preconditioning effects, PGC-1α and mitochondrial biogenesis, AMPK activation, and dampening inflammatory pathways like NF-kB. This is why I think sildenafil deserves a seat at the longevity table, not just a spot in the performance category.Then we get into the human data and what I think is most compelling. Large datasets show associations with lower rates of cardiovascular events and lower all-cause mortality in PDE5 inhibitor users. We talk heart attacks, strokes, endothelial repair, and why this class may act like an exercise mimetic for certain people by improving hemodynamics and oxygen delivery. We also cover pulmonary benefits, including its FDA-approved use for pulmonary arterial hypertension, and why that matters for aging lungs, sleep apnea-related pulmonary issues, and even high-altitude physiology.The brain section is the one that makes most people stop and rethink everything. There are observational datasets suggesting meaningfully lower Alzheimer's and dementia incidence in sildenafil users, plus plausible mechanisms tied to cerebral blood flow, synaptic plasticity, inflammation reduction, and mitochondrial support inside the brain. I'm not saying it's a magic bullet. I am saying it's one of the more interesting repurposing conversations in longevity right now.

What if the biggest metabolism disruptor today is not carbs or calories, but the toxic load you cannot see? In this episode of the Metabolic Freedom Podcast, Ben Azadi sits down with Mara Labs co-founders David Roberts and Dr. John Gildea for a deep dive into microplastics, detox pathways, and the science of sulforaphane. They break down how microplastics and the chemicals that leach from plastics can interfere with cellular function, including lysosomes, autophagy, inflammation, and hormone signaling. You will learn why sulforaphane is known for activating Nrf2, what that means for detox and repair genes, and why the conversation around metabolic health is also a conversation about toxin exposure. They also discuss berberine as a tool for metabolic flexibility, blood sugar support, ketosis, and even sleep, plus new product innovations like BarkElite for dogs. If you want practical strategies backed by research and real-world testing, this one is packed. Key Topics Covered Why microplastics are everywhere and why that matters for metabolism and longevity How microplastics may interfere with lysosomes, autophagy, and cellular cleanup What sulforaphane is and how it activates the Nrf2 pathway Phase 1, 2, and 3 detox explained in plain English Why inflammation is often the real root issue behind stubborn fat loss Berberine, AMPK, GLP-1 signaling, and metabolic flexibility Why late-night eating can wreck sleep and HRV The dog angle: joint support, inflammation, and BarkElite Coupon and Discount  Browse all products featured in this episode : http://www.benazadi.com/mara Mara Labs discount code: FREEDOM 25% off from January 19, 2026 through January 26, 2026 After January 26, 2026: code still works for 15% off Follow Ben Azadi

In episode 181 of the Fit Mother Project Podcast, Dr. Anthony Balduzzi kicks off a powerful new solo teaching series with a message that cuts straight to the core: after 40, muscle is not optional. It is the master regulator of aging, metabolism, hormones, and long-term independence - even for women.Dr. Balduzzi explains why aging is not about birthdays, but about muscle loss — and how strength training directly improves fat loss, insulin sensitivity, mitochondrial health, joint integrity, nervous system resilience, and even brain function. This episode reframes exercise from a “nice to have” into a foundational survival skill for modern life.If you want to feel stronger, leaner, more energized, and mentally sharp in 2026 and beyond, this episode will permanently change how you think about training — and why building muscle may be the single most important health decision you make this year.Rate & Review: If this episode resonated, please leave a 5-star rating and short review — it helps us reach more families.Join the Community: Visit www.fitmotherproject.com to train with us inside the programs.Next Week's Episode: Tune in next week for Part 2 — Why Insulin Sensitivity Changes Everything.Key TakeawaysMuscle is the master regulator of aging after 40Aging is driven by muscle loss, not chronological yearsStrength training improves fat loss by raising metabolic capacityMuscle acts as a glucose reservoir and improves insulin sensitivityMyokines released from muscle support healthy hormonesLow testosterone is epidemic — muscle is part of the solutionJoint pain often reflects muscle weakness, not joint damageGrip strength strongly predicts lifespan and independenceResistance training triggers mitochondrial biogenesisExercise activates longevity pathways: mTOR, AMPK, sirtuinsMuscle training strengthens the nervous system and brainProgressive resistance is essential for continued adaptationConsistency matters more than extreme intensityRecovery, sleep, and protein drive long-term gainsCreatine is a simple, safe, evidence-based support supplementBEAM Minerals—What a Difference!See what Beam Minerals can do for your health at beamminerals.com/fitfamily. Be sure to use the code FITFAMILY for 20% off your first order.Take an Adventure with FMP in 2026!Belize Service Trip — June 6-12, 2026. For information:

In episode 272 of the Fit Father Project Podcast, Dr. Anthony Balduzzi kicks off a powerful new solo teaching series with a message that cuts straight to the core: after 40, muscle is not optional. It is the master regulator of aging, metabolism, hormones, and long-term independence.Dr. Balduzzi explains why aging is not about birthdays, but about muscle loss — and how strength training directly improves fat loss, insulin sensitivity, mitochondrial health, joint integrity, nervous system resilience, and even brain function. This episode reframes exercise from a “nice to have” into a foundational survival skill for modern life.If you want to feel stronger, leaner, more energized, and mentally sharp in 2026 and beyond, this episode will permanently change how you think about training — and why building muscle may be the single most important health decision you make this year.Rate & Review: If this episode resonated, please leave a 5-star rating and short review — it helps us reach more families.Join the Community: Visit www.fitfatherproject.com to train with us inside the programs.Next Week's Episode: Tune in next week for Part 2 — Why Insulin Sensitivity Changes Everything.Key TakeawaysMuscle is the master regulator of aging after 40Aging is driven by muscle loss, not chronological yearsStrength training improves fat loss by raising metabolic capacityMuscle acts as a glucose reservoir and improves insulin sensitivityMyokines released from muscle support healthy hormonesLow testosterone is epidemic — muscle is part of the solutionJoint pain often reflects muscle weakness, not joint damageGrip strength strongly predicts lifespan and independenceResistance training triggers mitochondrial biogenesisExercise activates longevity pathways: mTOR, AMPK, sirtuinsMuscle training strengthens the nervous system and brainProgressive resistance is essential for continued adaptationConsistency matters more than extreme intensityRecovery, sleep, and protein drive long-term gainsCreatine is a simple, safe, evidence-based support supplementBEAM Minerals—What a Difference!See what Beam Minerals can do for your health at beamminerals.com/fitfamily. Be sure to use the code FITFAMILY for 20% off your first order.Take an Adventure with FFP in 2026!Fit Father Sedona Retreat — April 2026....

In this episode of the Omnia Performance Podcast, Fergus Crawley and Dr. Phil Price cut through the noise on concurrent training's interference effect. They unpack the science - from AMPK vs. mTOR signaling to why your training history matters - and deliver practical programming strategies for hybrid athletes. The bottom line? You can't optimize everything at once. Smart training means strategically consolidating stress and accepting the right compromises. Join The Wintering Training Plans and CoachingBook your FREE consultation callHybrid Training Guide (100% FREE)

Send us a textWhat if the best medicine you take this week doesn't come in a bottle, a supplement, a perfectly periodized strength program, or a color-coded workout app… but from simply moving your body the way it was designed to move?In this week's episode of Ending Physician Overwhelm, we're looking at rhythmic movement — walking, running, swimming, biking, anything repetitive and steady — and why it is one of the most powerful, accessible stress-reducers we have.And yes… we're talking real stress reduction. Not “go for a walk because it's good for you.” Not “steps are important.” We're talking:✨ Actual telomere protection✨ Improved cellular resilience✨ Better cognitive processing & creativity✨ Nervous system regulation✨ The kind of mental clarity you cannot get staring at a computerIf you've ever wondered why your best thinking happens on a walk (and never while screaming at your inbox), this episode breaks it all down.In this episode, we explore:• Why rhythmic movement has measurable effects on telomerase and telomere lengthThe Telomere Effect highlights two specific kinds of exercise that protect your DNA: moderate aerobic movement and HIIT. The surprise? Strength training did not have the same effect — which doesn't mean “don't lift,” it just means rhythmic movement deserves its own spotlight.• Movement as meditation (even if you're listening to a podcast or audiobook)Your brain needs space to think its own thoughts — unstructured, uninterrupted time that no number of productivity apps can replicate. Rhythmic movement is one of the easiest ways to access that state.• Why physicians need mindful motion more than ever Between the broken healthcare system, endless inbox escalation, and policy shifts that directly impact our patients… our bodies are absorbing far more stress than we realize. Movement helps metabolize what can't be solved.• How rhythmic movement stimulates autophagy & cellular cleanupWhen you move rhythmically, you activate AMPK and other repair pathways that make your cells more efficient, more resilient, and frankly… younger.• Practical, zero-perfection ways to start You don't need to run. You don't need to sweat. You don't need special leggings. You need: 10 minutes. A door. Your body. Repeat.If you're following the 10-Week Stress Reduction Challenge…Here's where we are:Week 1 → Yoga NidraWeek 2 → GreensWeek 3 → BreathWeek 4 → SleepWeek 5 → Laughter + PlayWeek 6 → BerriesWeek 7 → Rhythmic MovementLayer this on top of your other practices — gently, imperfectly.Every little nudge you give your nervous system matters.Resources Mentioned• The Telomere Effect — available through Megan's Bookshop.org page (not Amazon

Are you doing all the right things—clean eating, daily workouts, supplements—yet feeling tired, inflamed, or stuck in a midlife plateau? On today's deep-dive episode of The Coach Debbie Potts Show, we unravel the hidden biology behind slow metabolism, stubborn fat gain, chronic fatigue, and the loss of muscle as we age. Coach Debbie Potts—FDN-P, FNTP, NASM-CPT, and certified PNOĒ Metabolic Analyst—guides you through the interconnected systems that determine how you age, burn fat, build muscle, and generate energy from the inside out. This is not your typical "eat less, move more" conversation. This is FutureYou Biology—the science of rebuilding metabolism, rewiring resilience, and restoring cellular safety so you can thrive, not struggle, in midlife. In This Episode, You'll Learn: PNOĒ Metabolic Testing — Your Real-Time Metabolic Blueprint How RER, VO₂ Max, FatMax, and ventilatory efficiency reveal whether your metabolism is stuck in sugar-burning mode or capable of efficient, flexible fat oxidation. AMPK — The Fat-Burning, Repair, and Longevity Switch Why Zone 2, fasting windows, cold exposure, and specific nutrients activate AMPK to improve mitochondria, reduce inflammation, and enhance metabolic flexibility. The Cell Danger Response (CDR) — When Mitochondria Hit the Brakes Based on Dr. Robert Naviaux's research, we explore why chronic stress, toxins, infections, or trauma push your mitochondria into "protection mode"—slowing metabolism, lowering energy, and blocking fat loss. The Vagus Nerve — The Hidden Root of Weight Loss Resistance If your nervous system doesn't feel safe, your metabolism won't unlock. Learn how vagal tone affects digestion, hormones, inflammation, and fat-burning—and how to train the vagus for better metabolic outcomes. mTOR + Protein After 40 — How to Rebuild Muscle & Strength Why women and men after 40 need higher protein, targeted leucine, and heavy strength training to overcome anabolic resistance and maintain metabolic rate and longevity. Cortisol, Hormones & Aging The stress-metabolism connection: how elevated cortisol suppresses thyroid function, blocks fat burning, and accelerates aging—and how to fix the rhythm. The FutureYou™ Formula How AMPK, mTOR, the vagus nerve, and mitochondrial health integrate into a personalized, test-not-guess blueprint for metabolic harmony. Featured Framework: FutureYou™ Meal Method Protein-forward, leucine-optimized meals to turn on muscle protein synthesis, maintain metabolic health, and improve fat-burning—especially for midlife women and men. "Protein is the ignition switch for metabolism. Leucine is the spark plug." — Coach Debbie Takeaway Aging well isn't luck—it's strategy. When you retrain metabolism, restore cellular safety, and rebuild vagal resilience, your body becomes capable of fat-burning, muscle building, and long-lasting energy again. It's time to rewrite your midlife biology and create your FutureYou. Work With Coach Debbie Ready to stop guessing and start testing? Book your PNOĒ Metabolic Test or schedule a discovery call at:

In this episode, Ben reveals the 3-day science-backed protocol that rapidly reverses fatty liver — one of the most overlooked drivers of weight gain, fatigue, bloating, cravings, and insulin resistance. One in three people have fatty liver and don't know it, but research shows you can transform your liver and metabolism in as little as 72 hours with a simple, free, strategic approach. Ben breaks down three powerful human studies showing how fasting switches the liver into fat-burning mode within hours, activates AMPK to reduce inflammation, improves insulin sensitivity, and lowers liver fat fast. He also shares the step-by-step daily plan: Day 1: Choose your fasting level, break your fast with the Liver Flush Plate, and follow the circadian liver reset Day 2: Morning ACV protocol, post-meal walks, and zero fructose Day 3: Liver Reset Meal and inflammation control You'll learn the exact foods that stimulate bile flow, the nutrients that repair liver cells, what to avoid, and how to sync your meals with your circadian rhythm for maximum healing. This simple 3-day fix leads to less bloating, better digestion, improved liver enzymes, increased energy, deeper sleep, and noticeable fat loss — all by working with your body's innate healing ability. If you've struggled with stubborn belly fat or unexplained metabolic issues, this episode gives you the blueprint to take back control in just 72 hours. FREE GUIDE: The World's Easiest Breakfast Diet - https://bit.ly/4pGKrfW 

Informed Dissent with Dr. Jeff Barke and Dr. Mark McDonald – Jeff explores inflammation with Dr. Barry Sears, revealing how chronic low-level immune activation silently damages bodies and minds. He highlights the AA to EPA ratio, the power of omega-3s, and a steady, protein-balanced, polyphenol-rich eating plan that supports AMPK and healing while warning against quick fixes like GLP-1 drugs that threaten metabolic health and...

Informed Dissent with Dr. Jeff Barke and Dr. Mark McDonald – Jeff explores inflammation with Dr. Barry Sears, revealing how chronic low-level immune activation silently damages bodies and minds. He highlights the AA to EPA ratio, the power of omega-3s, and a steady, protein-balanced, polyphenol-rich eating plan that supports AMPK and healing while warning against quick fixes like GLP-1 drugs that threaten metabolic health and...

In this episode of the Gladden Longevity Podcast, Dr. Jeffrey Gladden and Trevor Connor delve into the intricacies of nutrition, particularly focusing on the Paleo diet, its principles, and its implications for health and longevity. Trevor shares his personal journey from professional cycling to studying nutrition, highlighting the importance of nutrient density and the role of glycemic load in dietary choices. They discuss the significance of the glycocalyx in vascular health, the impact of antioxidants on exercise adaptations, and the interplay between genetics and endurance training. The conversation emphasizes the necessity of balancing diet and exercise for optimal health. In this conversation, Dr. Jeffrey Gladden and Trevor Connor explore the intricate relationship between diet, exercise, and longevity, particularly focusing on the Paleo diet. They discuss common misconceptions about the diet, the importance of balance and variety in nutrition, and the role of metabolic pathways like AMPK and P53 in health. The conversation emphasizes the significance of genetic testing to tailor dietary choices and the need for a balanced approach to fueling during exercise. They conclude with resources for further learning about the Paleo diet and its benefits for health and longevity.    For Audience        Use code 'Podcast10' to get 10% OFF on any of our supplements at https://gladdenlongevityshop.com/ !    Takeaways         Trevor Connor transitioned from professional cycling to studying nutrition.         The Paleo diet emphasizes foods our ancestors evolved with.         Nutrient density is more important than macronutrient ratios.         Glycemic load is a key factor in dietary health.         The glycocalyx plays a crucial role in vascular health.         Antioxidants can hinder training adaptations if taken pre-exercise.         Genetics influence how individuals respond to endurance training.         Strength training may enhance antioxidant defenses more than endurance training.         A balanced approach to diet and exercise is essential for health.         You cannot out supplement a poor diet.  You can't run your way out of a bad diet.         A balanced approach to diet is crucial.         Biology operates on the principle of balance.         Variety in diet is essential for health.         Understanding metabolic pathways is key to longevity.         Genetic testing can guide dietary choices.         Fueling during exercise should be based on individual needs.         The sports nutrition world may promote unhealthy practices.         Natural foods are better for health than processed sugars.         Focus on overall health rather than just performance.   Chapters 00:00 Introduction to Longevity and Nutrition 02:59 Trevor's Journey into Paleo Diet 05:52 Understanding the Paleo Diet 09:02 Nutrient Density and Glycemic Load 12:01 The Role of Glycocalyx in Vascular Health 14:59 Antioxidants and Exercise Adaptations 17:57 Genetics and Endurance Training 20:51 Balancing Diet and Exercise for Optimal Health 23:12 The Balance of Diet and Exercise 24:51 Misconceptions of the Paleo Diet 27:38 Metabolic Flexibility and Variety in Diet 29:38 Understanding AMPK and P53 Pathways 32:23 The Importance of Genetic Testing 36:50 Fueling During Exercise: Myths and Realities To learn more about Trevor Connor/Paleo Diet:Facebook: https://www.facebook.com/RealPaleoDiet/ Instagram: https://www.instagram.com/realpaleodiet/ Email: info@thepaleodiet.com Website: thepaleodiet.com   Got a question for Dr. Gladden? Submit it using the link below and it might be answered in our next Q&A episode! https://form.typeform.com/to/tIyzUai7? Reach out to us at:    Website: https://gladdenlongevity.com/     Facebook: https://www.facebook.com/Gladdenlongevity/    Instagram: https://www.instagram.com/gladdenlongevity/?hl=en     LinkedIn: https://www.linkedin.com/company/gladdenlongevity    YouTube: https://www.youtube.com/channel/UC5_q8nexY4K5ilgFnKm7naw     Gladden Longevity Podcast Disclosures Production & Independence The Gladden Longevity Podcast and Age Hackers are produced by Gladden Longevity Podcast, which operates independently from Dr. Jeffrey Gladden's clinical practice and research at Gladden Longevity in Irving, Texas. Dr. Gladden may serve as a founder, advisor, or investor in select health, wellness, or longevity-related ventures. These may occasionally be referenced in podcast discussions when relevant to educational topics. Any such mentions are for informational purposes only and do not constitute endorsements. Medical Disclaimer The Gladden Longevity Podcast is intended for educational and informational purposes only. It does not constitute the practice of medicine, nursing, or other professional healthcare services — including the giving of medical advice — and no doctor–patient relationship is formed through this podcast or its associated content. The information shared on this podcast, including opinions, research discussions, and referenced materials, is not intended to replace or serve as a substitute for professional medical advice, diagnosis, or treatment. Listeners should not disregard or delay seeking medical advice for any condition they may have. Always seek the guidance of a qualified healthcare professional regarding any questions or concerns about your health, medical conditions, or treatment options. Use of information from this podcast and any linked materials is at the listener's own risk. Podcast Guest Disclosures Guests on the Gladden Longevity Podcast may hold financial interests, advisory roles, or ownership stakes in companies, products, or services discussed during their appearance. The views expressed by guests are their own and do not necessarily reflect the opinions or positions of Gladden Longevity, Dr. Jeffrey Gladden, or the production team. Sponsorships & Affiliate Disclosures To support the creation of high-quality educational content, the Gladden Longevity Podcast may include paid sponsorships or affiliate partnerships. Any such partnerships will be clearly identified during episodes or noted in the accompanying show notes. We may receive compensation through affiliate links or sponsorship agreements when products or services are mentioned on the show. However, these partnerships do not influence the opinions, recommendations, or clinical integrity of the information presented. Additional Note on Content Integrity All content is carefully curated to align with our mission of promoting science-based, ethical, and responsible approaches to health, wellness, and longevity. We strive to maintain the highest standards of transparency and educational value in all our communications.  

How do we protect our children from predators hiding in plain sight? Josh Trent welcomes Nate Lewis, Child Protection Advocate and Founder of The Innocent, to the Wellness + Wisdom Podcast, episode 778, to expose the devastating reality of modern child exploitation, what every parent must do to safeguard their family, why innocence is no longer protected in our culture, how social media have become the new predators, and what it takes to raise grounded, resilient children in a digital world designed to distract and divide. In This Episode, Nate Lewis Uncovers: [01:20] How to Protect Your Children How we can preserve the innocence of a child. Why we need to protect children differently in the age of technology. The importance of community support. Why the next generations are going to make radical changes. Resources: Nate Lewis [05:10] Humanizing The Investigation Process How 756,000 children go missing in the US every year. Why Nate's team coaches law enforcement on a new approach to investigation. How law enforcement often sees sex workers as criminals, not as humans. Resources: 756 Dark [09:50] The Importance of Children's Innocence Why innocence is not celebrated anymore. How some parents don't allow their children to be children. Why children are distracted by screens so that parents can rest. How Nate made it his priority to show up for his children. [15:50] How Can You Protect Your Children from Online Threats? Why parents need to learn how to protect children online. How child's identity is tied to how many friends or followers they have. The biggest dangers online for young children. Why not giving children a phone doesn't prevent them from online threats. The importance of teaching boys respect towards women. [22:20] Cultivate A Safe Relationship with Your Children How children's safety starts with the parents building a safe relationship with them. Why parents need to meet their children where they're at. The importance of building trust in our children instead of fear. [27:40] Adulthood Doesn't Start at 18 Why children don't become adults at the age of 18. How life experience is what makes a person an adult. Why Nate always wanted to have deep conversations with his parents. How many parents don't have the emotional faculty to hold difficult conversations with their children. Why parents have the responsibility to find tools to make them better parents. How it's common for parents to mess up the order of priorities. [32:20] Why Children Get Trapped in Sex Trafficking Why children need to make their social media accounts private. How it's traumatizing for girls to receive photos of male genitalia. How many of the girls who are sex trafficked fall in love with strangers online. The importance of a male role model in children's lives. Why child molesters choose children where the father isn't a threat. Resources: Jack Reynolds [39:35] Social Media Puts Your Children in Danger Why AI is not searching for online predators. How the algorithm pushes old men to meet young girls. Why the people who create social media platforms don't have a moral compass. How children are recruited for sex trafficking mostly through Facebook, Snapchat, and Instagram. Resources: 644 QUADCAST | Liberation of The SELF, U.S.A. Common Law + Unmasking Health Myths with Aaron Abke, Luke Storey, Alec Zeck + Josh Trent [48:20] Getting Back to The Old Ways How Josh got addicted to pornography. Why we need to stop blaming our parents. How having a difficult conversation is still easier than having our children fall into the hands of a sex predator. Why children should know who can or cannot see the private parts of their bodies. What made Nate decide not to be on social media and not have a TV at home. The importance of having a dedicated family time. [54:10] Your Kids Don't Need a TV How Josh teaches his children respect. Why we need to remove chaos from life and go back to a simple life. How parents can entertain children without using any screens. [58:20] Advice to Fathers Why almost no father is truly ready for fatherhood. How the most important thing for parents is to act from a place of love. Why children's brains don't perceive reality the same way as us. The importance of comforting our children when they're upset. [01:01:50] In Order to Heal, You Have to Feel How anger can help us find the solution. Why Nate hasn't figured out why there is evil in the world. How he copes with anger and sadness. Why not drinking alcohol helps him deal with his emotions. The importance of feeling our emotions. [01:09:05] The Injustice in Child Sex Trafficking Why Nate carries hate and anger inside him because of the evil he's seen happening to children. How we need to get the power back to help children against predators. Why judges often only give a 2-year sentence to sex predators, even though they should get 25 years. How many officers don't understand the importance of crime prevention. Why some people in power are not supporting the human trafficking resolution. [01:19:05] Why Do Evil Things Happen to Innocent Children? How we can help make a change. What brings Josh peace. How we can't ever understand why evil exists. Why death is not the end and our suffering on Earth is worth it. How humans default setting is to love. Why the world is also full of light and kind people. Resources: 629 The Truth About Circumcision: Ending Male Genital Mutilation + Protecting Infant Innocence | Eric Clopper "756,000 children go missing in America every year. Nearly 80% of victims are girls, and most of them get into trafficking because they fall in love with a guy. He knows how to manipulate them." — Nate Lewis Leave Wellness + Wisdom a Review on Apple Podcasts

Is Human Design a shortcut to finding your purpose and becoming your authentic self? Josh Trent welcomes Emma Dunwoody, Human Design Expert, to the Wellness + Wisdom Podcast, episode 776, to reveal how Human Design helps you break free from conditioning, trust your intuition, reconnect with the subtle energy guiding your purpose, and empower you to live in full alignment with who God designed you to be. Join The Decode Your Design Masterclass You don't need another strategy or another plan: you need the truth, a breakthrough, a moment where it all clicks, and you finally understand why success has felt so hard. And that breakthrough you've been looking for? It's not outside of you. It's in your Human Design. This masterclass will shift you from burnout to alignment, from doubt to deep self-trust, and from strategy addiction to inner authority, in under 90 minutes. Because when you stop fighting against who you are and start working with your design, everything changes. Join Emma's Masterclass Today + Get 20% off with Code "JOSH20" In This Episode, Emma Dunwoody Uncovers: [01:10] Use Human Design to Become More Authentic Why Human Design serves as a permission slip to be ourselves. How Human Design bypasses the mind that tells us who we think we are. The role of neutrinos in imprinting ourselves in the moment. Why Emma used to be skeptical of Human Design. How Human Design was invented. Resources: Emma Dunwoody Human Design Made Simple by Emma Dunwoody Decode Your Design Masterclass - 20% off with Code "JOSH20" [07:50] How to Integrate What You've Learned Why transformation is not easy. How Emma's healing her childhood trauma with the help of Human Design. Why we need to integrate the information we learn about ourselves in order to transform our lives. [12:35] How to Find Your Purpose How a chart has more than 2 billion expressions. Why we don't have to change anything based on our chart reading. How Emma's son's energy helped her improve her mental health. Why our purpose is to be ourselves. [17:20] Human Design + Plant Medicine How Josh and Emma's Human Design revealed their design is to go through difficult challenges. Why manifesting generators can be seen as too much by others. What is a personal Human Design profile. The gift of gate 64. [26:10] What's Blocking Your Transformation Why only our ego can stop our transformation. How Human Design and Gene Keys show us our shadows. Why Emma never wanted to stick to one career path. How we can turn our shadows into indicators. [30:20] Learn to Listen to The Subtle Energies Why we're meant to become our own guide. How it's become very difficult to differentiate between right and wrong. Why some people are not designed to make quick decisions. How we're disconnected from the subtle energies and signals of our bodies. Why Emma can't use muscle testing on herself. [37:20] How to Trust Yourself Why we need to rise above the male and female archetypes. How Human Design taught Emma to trust herself. Why she didn't realize she was talking to God until she was in her 30s. How she struggled to find one thing to focus on. [41:40] The 5 Human Design Archetypes How we only need to understand the surface information about ourselves. Why manifestors are not designed to finish what they've started. How generators are here to build a new world. The role of manifesting generators. Why projectors are the guides that make others better. How only 1% of the population is reflectors. [49:30] The Purpose of Human Design Where the Human Design truly came from. How we're entering the gate of intimacy and abundance. Why the purpose and meaning of intimacy have been changing. How Human Design can help us evolve. [53:20] Heal Your Trauma with Human Design The issue with genetic determinism. How each Gene Key is associated with a part of the body, which is translated as "gates" in Human Design. What it was like for Emma to grow up with parents who were alcoholic and anorectic. How Human Design can help us start healing our trauma. The difference between Gene Keys and Human Design gates. Why Emma used to live in the masculine role. [01:01:50] Human Design Helps Raise Empowered Children The importance of raising our children according to their Human Design. How we're conditioned and taught to change ourselves. Why we're too attached to right and wrong. [01:07:00] Evolution of Humanity Why Emma's mission is to make Human Design mainstream. How we're moving from thinking doers to feeling be-ers. Why getting into our body is the most important thing we can do right now. How indigenous Australians pass down their knowledge through stories. What Emma does to empower her son. [01:13:50] Alignment Creates Flow Why projectors can have a bad reputation. How successful people are in alignment with who they truly are. What helped Emma to finish writing her book. How the process of writing and publishing her book was in alignment with her design. Leave Wellness + Wisdom a Review on Apple Podcasts All Resources From This Episode Emma Dunwoody Human Design Made Simple by Emma Dunwoody Decode Your Design Masterclass - 20% off with Code "JOSH20" Power Quotes From Emma Dunwoody "Human design bypasses the mind. It goes straight to the energetic blueprint that's coded in your DNA. This energetic blueprint happened at your birth, as subatomic particles moved through your body and imprinted your DNA. It's the map that's going to lead you back to the most authentic version of you." — Emma Dunwoody "We think we know who we're meant to be and what we're meant to do and we really don't. We can't see that big picture. When you start living more in alignment with your Human Design, you learn to tap into the body, and you're constantly told in every moment what is right for you and what isn't." — Emma Dunwoody "Our purpose is bigger than the job that we do. Our purpose is our energy. Our greatest purpose is just to be our most authentic self, because then we are fulfilling the puzzle piece we need to fulfill to move to this new world." — Emma Dunwoody

Liberated Life Series | Episode 775 Join Josh Trent, host of the Wellness + Wisdom Podcast, and Mar, co-host of the Liberated Life Series, as they expose the shocking truth about the meaning of life. Why do money, success, and approval so often leave us empty? And how can struggle, the very thing we try to avoid, become the secret key to fulfillment? If you've ever asked yourself why achievements don't make you happy or why the search for purpose collapses into anxiety, this episode will shake your perspective, reveal where most people get meaning wrong, and guide you toward a deeper truth that can never be taken away. We ALL have problems. Stop hiding. Start living life liberated. Learn how to set yourself free from self-sabotage, limiting beliefs, thoughts, and behaviors so you will have lifelong confidence and clarity of purpose through a thriving community and practical tools, guiding you to play a new reality game. Join Josh and others in the Liberated Life Tribe to: Discover lifelong confidence, clarity, and a true sense of purpose with practical tools and a supportive community. Learn to rewrite your reality + master a new “reality game.” Unlock your highest potential in your physical, mental, emotional, spiritual + financial SELF beyond your wildest dreams through accessing the power of surrender to trust life + create new results. Join the Tribe Today (It's FREE) Listen To Episode 775 As Josh Trent Uncovers: [00:00] If You Died Tomorrow, Would Your Life Mean Anything? Why chasing money, approval, or success leaves most people empty. The shocking truth: achievements without alignment always collapse into anxiety. How Emotional Epigenetics™ reveals that unresolved trauma blocks real fulfillment. Why true meaning only comes when your biology no longer argues with your reality. [07:20] Why Doing the Dishes Could Save Your Soul How finding joy in boring, everyday tasks rewires your relationship with life. Why “mundane moments” are the secret to lasting peace. The hidden danger of chasing dreams while ignoring the present. How presence in small things creates capacity for true abundance. [11:55] Happiness Is a Fool's Game Why Jordan Peterson warns against chasing happiness. The paradox of suffering: struggle is the fuel for deeper joy. How resistance is life signaling you to grow, not a sign to quit. Why maturity means embracing suffering as necessary for fulfillment. [14:55] The 8-Step Authentic Abundance Formula The proven roadmap: Values → Identity → Purpose → Dream → Vision → Gift → Give → Receive → Repeat. Why clarity on values is the non-negotiable foundation of identity transformation. How journaling through these 8 steps gives you a clear, personal life plan. The shocking truth: you can't shortcut embodiment - even ChatGPT can't do the work for you. [21:40] Why Planning Alone Will Keep You Stuck Why silent internal blocks only dissolve when exposed in community. The hidden cost of trying to figure it out by yourself. How tribe accountability reveals the lies trauma imprints into your biology. Why the Liberated Life Tribe™ is essential: we are not designed to evolve in isolation. [23:55] Turning Suffering Into a Spiritual Weapon Why acceptance transforms pain into fuel for your highest dreams. The radical mindset shift: nothing is good or bad - thinking makes it so. How neutrality and trust alchemize struggle into growth. Why resistance is secretly the doorway to your next level of meaning. [25:35] Life Has No Meaning... Until You Choose One The bus metaphor: two passengers, same ride, two radically different realities. How perspective creates meaning, even when facts stay the same. Why focusing on despair destroys - from Robin Williams to everyday burnout. [27:30] What Is The True Meaning of Life? Why unconditional love is the real test of human existence. How community and connection become the antidote to despair. Why peace must be the foundation of true power. The ultimate paradox: God is everything and nothing - and love is the only meaning we get to create. Leave Wellness + Wisdom a Review on Apple Podcasts Links From Today's Show  Zen and the Art of Motorcycle Maintenance by Robert M. Pirsig Emotional Epigenetics™: The Sacred Science of Identity Transformation (Remember Who You Are) The Talk: Philip Seymour Hoffman & Robin Williams (Part 2) 

Most people fast to lose fat—but they're missing one key piece that can boost results by 33%. In this episode, Ben Azadi breaks down the science of fasted exercise, how to activate your body's fat-burning switch (AMPK), and why movement during fasting is the real catalyst for transformation. You'll learn: Why exercising before breakfast burns significantly more fat The 5 physiological benefits of fasted workouts (from insulin drops to autophagy) The best exercises to do in a fasted state (for men and women) What to drink before your workout without breaking your fast The ideal way to break your fast for continued fat-burning Common mistakes that stall progress—and how to fix them Ben also shares his 3-Day Fasted Exercise Reset Protocol and a free bonus guide — the Keto Egg Fast Protocol — to accelerate results and reboot your metabolism.

In this episode we dive into a hotly debated topic: should you eat meat or not? Ben is joined by two powerhouse guests with decades of experience in nutrition and health—Dr. Shawn Baker, best-selling author of The Carnivore Diet and leading carnivore advocate, and Joel Greene, creator of The Immunity Code and champion of dietary diversity. In this spirited debate, Dr. Baker highlights the benefits of a strict carnivore approach—meat, eggs, some dairy, and minimal plant foods—not only for himself but also for patients managing chronic health issues. He explains why animal-based nutrition can be so effective, breaks down the science of ketosis and gut health, and responds to concerns about long-term effects of fiber-free diets. Meanwhile, Joel Greene makes the case for dietary variety, drawing from evolutionary biology, clinical research, and personal experience. He explores the synergies of combining animal and plant foods, the role of fiber in gut and immune health, and the ancestral rhythms of scarcity and feasting. Joel argues that even small amounts of diverse foods can offset downsides of strict elimination diets. Dr. Baker is a physician, athlete, and author known for his straightforward, meat-focused approach to nutrition and his background in strength sports. Joel is the creator of Veep Nutrition, a program targeting gut communities to improve health, used by major employers and featured on the Dr. Phil Show. Author of The Immunity Code, Joel has devoted 50 years to health and anti-aging, pioneering practices like MCTs in the ’80s, keto in the ’90s, and AMPK activation by 2009. At 55, he remains a 100% natural athlete. Full show notes: bengreenfieldlife.com/diversityorcarnivore Episode Sponsors: Unmatched: Outlier by Unmatched is the world's first pre-workout featuring Paraxanthine instead of caffeine, delivering sustained energy and focus without the crash, plus premium ingredients like Cognizin for cognitive enhancement and NO3-T for incredible muscle pumps. Try it at unmatchedsupps.com/bengreenfield with special bulk discounts: 15% off one, 20% off two, or 25% off three. Xtendlife: Future-proof your health with Xtendlife’s Total Balance—100+ bio-active ingredients in a gender-specific formula designed for longevity and complete daily support. Use code BEN15 at www.xtend-life.com/ben for 15% off sitewide, plus free shipping. IM8: Ditch the cabinet full of supplements—IM8 packs 92 powerhouse ingredients into one delicious scoop for all-day energy, gut health, and cellular support. Go to IM8Health.com and use code BEN for an exclusive gift—fuel your body the right way! LMNT: Everyone needs electrolytes, especially those on low-carb diets, who practice intermittent or extended fasting, are physically active, or sweat a lot. Go to DrinkLMNT.com/BenGreenfield to get a free sample pack with your purchase! Ketone-IQ: Ketone-IQ delivers science-backed performance fuel that increases power output by 19%, reduces fatigue by 10%, and naturally boosts EPO production for better oxygen delivery—trusted by elite athletes like Jon Jones and Olympic champions. Save 30% on your subscription plus get a free gift with your second shipment at Ketone.com/BENG.See omnystudio.com/listener for privacy information.