Podcasts about ampk

In this episode of Ageless Future, Regan Archibald explores the groundbreaking molecule SLU-PP-332, a compound designed to mimic the metabolic benefits of exercise by activating key genetic and mitochondrial pathways. Originally developed by researchers at St. Louis University, SLU-PP-332 works through the ERR-alpha and AMPK pathways, promoting fat oxidation, mitochondrial biogenesis, and improved insulin sensitivity—without the oxidative stress of overtraining. Regan discusses how animal studies demonstrated dramatic improvements in endurance, fat loss, and glucose control, and shares his own experience using SLU-PP-332 to enhance VO₂ max, energy, and recovery. He also outlines its potential applications for metabolic syndrome, muscle loss, inflammation, and even post-COVID mitochondrial dysfunction. The episode concludes with practical insights on stacking SLU-PP-332 with other peptides like MOTS-c, 5-Amino-1MQ, and BPC-157 for comprehensive metabolic rejuvenation, while emphasizing the foundation of longevity medicine: optimizing insulin sensitivity, mitochondrial efficiency, and consistent physical conditioning.www.agelessfuture.com

How do we protect our children from predators hiding in plain sight? Josh Trent welcomes Nate Lewis, Child Protection Advocate and Founder of The Innocent, to the Wellness + Wisdom Podcast, episode 778, to expose the devastating reality of modern child exploitation, what every parent must do to safeguard their family, why innocence is no longer protected in our culture, how social media have become the new predators, and what it takes to raise grounded, resilient children in a digital world designed to distract and divide. In This Episode, Nate Lewis Uncovers: [01:20] How to Protect Your Children How we can preserve the innocence of a child. Why we need to protect children differently in the age of technology. The importance of community support. Why the next generations are going to make radical changes. Resources: Nate Lewis [05:10] Humanizing The Investigation Process How 756,000 children go missing in the US every year. Why Nate's team coaches law enforcement on a new approach to investigation. How law enforcement often sees sex workers as criminals, not as humans. Resources: 756 Dark [09:50] The Importance of Children's Innocence Why innocence is not celebrated anymore. How some parents don't allow their children to be children. Why children are distracted by screens so that parents can rest. How Nate made it his priority to show up for his children. [15:50] How Can You Protect Your Children from Online Threats? Why parents need to learn how to protect children online. How child's identity is tied to how many friends or followers they have. The biggest dangers online for young children. Why not giving children a phone doesn't prevent them from online threats. The importance of teaching boys respect towards women. [22:20] Cultivate A Safe Relationship with Your Children How children's safety starts with the parents building a safe relationship with them. Why parents need to meet their children where they're at. The importance of building trust in our children instead of fear. [27:40] Adulthood Doesn't Start at 18 Why children don't become adults at the age of 18. How life experience is what makes a person an adult. Why Nate always wanted to have deep conversations with his parents. How many parents don't have the emotional faculty to hold difficult conversations with their children. Why parents have the responsibility to find tools to make them better parents. How it's common for parents to mess up the order of priorities. [32:20] Why Children Get Trapped in Sex Trafficking Why children need to make their social media accounts private. How it's traumatizing for girls to receive photos of male genitalia. How many of the girls who are sex trafficked fall in love with strangers online. The importance of a male role model in children's lives. Why child molesters choose children where the father isn't a threat. Resources: Jack Reynolds [39:35] Social Media Puts Your Children in Danger Why AI is not searching for online predators. How the algorithm pushes old men to meet young girls. Why the people who create social media platforms don't have a moral compass. How children are recruited for sex trafficking mostly through Facebook, Snapchat, and Instagram. Resources: 644 QUADCAST | Liberation of The SELF, U.S.A. Common Law + Unmasking Health Myths with Aaron Abke, Luke Storey, Alec Zeck + Josh Trent [48:20] Getting Back to The Old Ways How Josh got addicted to pornography. Why we need to stop blaming our parents. How having a difficult conversation is still easier than having our children fall into the hands of a sex predator. Why children should know who can or cannot see the private parts of their bodies. What made Nate decide not to be on social media and not have a TV at home. The importance of having a dedicated family time. [54:10] Your Kids Don't Need a TV How Josh teaches his children respect. Why we need to remove chaos from life and go back to a simple life. How parents can entertain children without using any screens. [58:20] Advice to Fathers Why almost no father is truly ready for fatherhood. How the most important thing for parents is to act from a place of love. Why children's brains don't perceive reality the same way as us. The importance of comforting our children when they're upset. [01:01:50] In Order to Heal, You Have to Feel How anger can help us find the solution. Why Nate hasn't figured out why there is evil in the world. How he copes with anger and sadness. Why not drinking alcohol helps him deal with his emotions. The importance of feeling our emotions. [01:09:05] The Injustice in Child Sex Trafficking Why Nate carries hate and anger inside him because of the evil he's seen happening to children. How we need to get the power back to help children against predators. Why judges often only give a 2-year sentence to sex predators, even though they should get 25 years. How many officers don't understand the importance of crime prevention. Why some people in power are not supporting the human trafficking resolution. [01:19:05] Why Do Evil Things Happen to Innocent Children? How we can help make a change. What brings Josh peace. How we can't ever understand why evil exists. Why death is not the end and our suffering on Earth is worth it. How humans default setting is to love. Why the world is also full of light and kind people. Resources: 629 The Truth About Circumcision: Ending Male Genital Mutilation + Protecting Infant Innocence | Eric Clopper "756,000 children go missing in America every year. Nearly 80% of victims are girls, and most of them get into trafficking because they fall in love with a guy. He knows how to manipulate them." — Nate Lewis Leave Wellness + Wisdom a Review on Apple Podcasts

Are you feeling stuck, inflamed, or frustrated that nothing seems to work anymore — even the so-called “miracle” GLP-1 medications? In this episode, Coach Debbie Potts explains why your metabolism probably isn't broken… it's misunderstood. Discover how PNOĒ Metabolic Testing and a Functional Health Investigation can reveal what's really driving your fatigue, weight gain, and burnout — and how to rebuild your metabolism naturally through The WHOLESTIC Method™ and your personalized FutureYou plan. You'll learn: What your breath can reveal about fat vs. carb metabolism How the Cell Danger Response shuts down energy production Why mitochondrial health is the key to longevity and vitality How sympathetic dominance and poor vagal tone block fat loss The balance between AMPK and mTOR for optimal aging Why VO₂ Max is one of the best predictors of longevity How to rebuild your health from the inside out — starting with drainage, detox, and nervous-system repair Why you can't out-supplement poor lifestyle habits or out-exercise a poor diet Debbie also shares how her clients use testing, not guessing, to identify their personal metabolic roadblocks — and how stacking consistent “base hits” with the Eight Elements of The WHOLESTIC Method™ leads to long-term transformation. Because aging isn't the enemy — unawareness is. ✨ Test your metabolism. Rebuild your energy. Redefine your Future You.

Is Human Design a shortcut to finding your purpose and becoming your authentic self? Josh Trent welcomes Emma Dunwoody, Human Design Expert, to the Wellness + Wisdom Podcast, episode 776, to reveal how Human Design helps you break free from conditioning, trust your intuition, reconnect with the subtle energy guiding your purpose, and empower you to live in full alignment with who God designed you to be. Join The Decode Your Design Masterclass You don't need another strategy or another plan: you need the truth, a breakthrough, a moment where it all clicks, and you finally understand why success has felt so hard. And that breakthrough you've been looking for? It's not outside of you. It's in your Human Design. This masterclass will shift you from burnout to alignment, from doubt to deep self-trust, and from strategy addiction to inner authority, in under 90 minutes. Because when you stop fighting against who you are and start working with your design, everything changes. Join Emma's Masterclass Today + Get 20% off with Code "JOSH20" In This Episode, Emma Dunwoody Uncovers: [01:10] Use Human Design to Become More Authentic Why Human Design serves as a permission slip to be ourselves. How Human Design bypasses the mind that tells us who we think we are. The role of neutrinos in imprinting ourselves in the moment. Why Emma used to be skeptical of Human Design. How Human Design was invented. Resources: Emma Dunwoody Human Design Made Simple by Emma Dunwoody Decode Your Design Masterclass - 20% off with Code "JOSH20" [07:50] How to Integrate What You've Learned Why transformation is not easy. How Emma's healing her childhood trauma with the help of Human Design. Why we need to integrate the information we learn about ourselves in order to transform our lives. [12:35] How to Find Your Purpose How a chart has more than 2 billion expressions. Why we don't have to change anything based on our chart reading. How Emma's son's energy helped her improve her mental health. Why our purpose is to be ourselves. [17:20] Human Design + Plant Medicine How Josh and Emma's Human Design revealed their design is to go through difficult challenges. Why manifesting generators can be seen as too much by others. What is a personal Human Design profile. The gift of gate 64. [26:10] What's Blocking Your Transformation Why only our ego can stop our transformation. How Human Design and Gene Keys show us our shadows. Why Emma never wanted to stick to one career path. How we can turn our shadows into indicators. [30:20] Learn to Listen to The Subtle Energies Why we're meant to become our own guide. How it's become very difficult to differentiate between right and wrong. Why some people are not designed to make quick decisions. How we're disconnected from the subtle energies and signals of our bodies. Why Emma can't use muscle testing on herself. [37:20] How to Trust Yourself Why we need to rise above the male and female archetypes. How Human Design taught Emma to trust herself. Why she didn't realize she was talking to God until she was in her 30s. How she struggled to find one thing to focus on. [41:40] The 5 Human Design Archetypes How we only need to understand the surface information about ourselves. Why manifestors are not designed to finish what they've started. How generators are here to build a new world. The role of manifesting generators. Why projectors are the guides that make others better. How only 1% of the population is reflectors. [49:30] The Purpose of Human Design Where the Human Design truly came from. How we're entering the gate of intimacy and abundance. Why the purpose and meaning of intimacy have been changing. How Human Design can help us evolve. [53:20] Heal Your Trauma with Human Design The issue with genetic determinism. How each Gene Key is associated with a part of the body, which is translated as "gates" in Human Design. What it was like for Emma to grow up with parents who were alcoholic and anorectic. How Human Design can help us start healing our trauma. The difference between Gene Keys and Human Design gates. Why Emma used to live in the masculine role. [01:01:50] Human Design Helps Raise Empowered Children The importance of raising our children according to their Human Design. How we're conditioned and taught to change ourselves. Why we're too attached to right and wrong. [01:07:00] Evolution of Humanity Why Emma's mission is to make Human Design mainstream. How we're moving from thinking doers to feeling be-ers. Why getting into our body is the most important thing we can do right now. How indigenous Australians pass down their knowledge through stories. What Emma does to empower her son. [01:13:50] Alignment Creates Flow Why projectors can have a bad reputation. How successful people are in alignment with who they truly are. What helped Emma to finish writing her book. How the process of writing and publishing her book was in alignment with her design. Leave Wellness + Wisdom a Review on Apple Podcasts All Resources From This Episode Emma Dunwoody Human Design Made Simple by Emma Dunwoody Decode Your Design Masterclass - 20% off with Code "JOSH20" Power Quotes From Emma Dunwoody "Human design bypasses the mind. It goes straight to the energetic blueprint that's coded in your DNA. This energetic blueprint happened at your birth, as subatomic particles moved through your body and imprinted your DNA. It's the map that's going to lead you back to the most authentic version of you." — Emma Dunwoody "We think we know who we're meant to be and what we're meant to do and we really don't. We can't see that big picture. When you start living more in alignment with your Human Design, you learn to tap into the body, and you're constantly told in every moment what is right for you and what isn't." — Emma Dunwoody "Our purpose is bigger than the job that we do. Our purpose is our energy. Our greatest purpose is just to be our most authentic self, because then we are fulfilling the puzzle piece we need to fulfill to move to this new world." — Emma Dunwoody

Liberated Life Series | Episode 775 Join Josh Trent, host of the Wellness + Wisdom Podcast, and Mar, co-host of the Liberated Life Series, as they expose the shocking truth about the meaning of life. Why do money, success, and approval so often leave us empty? And how can struggle, the very thing we try to avoid, become the secret key to fulfillment? If you've ever asked yourself why achievements don't make you happy or why the search for purpose collapses into anxiety, this episode will shake your perspective, reveal where most people get meaning wrong, and guide you toward a deeper truth that can never be taken away. We ALL have problems. Stop hiding. Start living life liberated. Learn how to set yourself free from self-sabotage, limiting beliefs, thoughts, and behaviors so you will have lifelong confidence and clarity of purpose through a thriving community and practical tools, guiding you to play a new reality game. Join Josh and others in the Liberated Life Tribe to: Discover lifelong confidence, clarity, and a true sense of purpose with practical tools and a supportive community. Learn to rewrite your reality + master a new “reality game.” Unlock your highest potential in your physical, mental, emotional, spiritual + financial SELF beyond your wildest dreams through accessing the power of surrender to trust life + create new results. Join the Tribe Today (It's FREE) Listen To Episode 775 As Josh Trent Uncovers: [00:00] If You Died Tomorrow, Would Your Life Mean Anything? Why chasing money, approval, or success leaves most people empty. The shocking truth: achievements without alignment always collapse into anxiety. How Emotional Epigenetics™ reveals that unresolved trauma blocks real fulfillment. Why true meaning only comes when your biology no longer argues with your reality. [07:20] Why Doing the Dishes Could Save Your Soul How finding joy in boring, everyday tasks rewires your relationship with life. Why “mundane moments” are the secret to lasting peace. The hidden danger of chasing dreams while ignoring the present. How presence in small things creates capacity for true abundance. [11:55] Happiness Is a Fool's Game Why Jordan Peterson warns against chasing happiness. The paradox of suffering: struggle is the fuel for deeper joy. How resistance is life signaling you to grow, not a sign to quit. Why maturity means embracing suffering as necessary for fulfillment. [14:55] The 8-Step Authentic Abundance Formula The proven roadmap: Values → Identity → Purpose → Dream → Vision → Gift → Give → Receive → Repeat. Why clarity on values is the non-negotiable foundation of identity transformation. How journaling through these 8 steps gives you a clear, personal life plan. The shocking truth: you can't shortcut embodiment - even ChatGPT can't do the work for you. [21:40] Why Planning Alone Will Keep You Stuck Why silent internal blocks only dissolve when exposed in community. The hidden cost of trying to figure it out by yourself. How tribe accountability reveals the lies trauma imprints into your biology. Why the Liberated Life Tribe™ is essential: we are not designed to evolve in isolation. [23:55] Turning Suffering Into a Spiritual Weapon Why acceptance transforms pain into fuel for your highest dreams. The radical mindset shift: nothing is good or bad - thinking makes it so. How neutrality and trust alchemize struggle into growth. Why resistance is secretly the doorway to your next level of meaning. [25:35] Life Has No Meaning... Until You Choose One The bus metaphor: two passengers, same ride, two radically different realities. How perspective creates meaning, even when facts stay the same. Why focusing on despair destroys - from Robin Williams to everyday burnout. [27:30] What Is The True Meaning of Life? Why unconditional love is the real test of human existence. How community and connection become the antidote to despair. Why peace must be the foundation of true power. The ultimate paradox: God is everything and nothing - and love is the only meaning we get to create. Leave Wellness + Wisdom a Review on Apple Podcasts Links From Today's Show  Zen and the Art of Motorcycle Maintenance by Robert M. Pirsig Emotional Epigenetics™: The Sacred Science of Identity Transformation (Remember Who You Are) The Talk: Philip Seymour Hoffman & Robin Williams (Part 2) 

Most people fast to lose fat—but they're missing one key piece that can boost results by 33%. In this episode, Ben Azadi breaks down the science of fasted exercise, how to activate your body's fat-burning switch (AMPK), and why movement during fasting is the real catalyst for transformation. You'll learn: Why exercising before breakfast burns significantly more fat The 5 physiological benefits of fasted workouts (from insulin drops to autophagy) The best exercises to do in a fasted state (for men and women) What to drink before your workout without breaking your fast The ideal way to break your fast for continued fat-burning Common mistakes that stall progress—and how to fix them Ben also shares his 3-Day Fasted Exercise Reset Protocol and a free bonus guide — the Keto Egg Fast Protocol — to accelerate results and reboot your metabolism.

I’m joined by Neal Mercado, Chief Science Officer at Melrose, one of Australia’s leading wellness brands and the team behind Melrose Future Lab. Neal leads a thought-provoking conversation on ageing, vitality, and the science behind what really works. We unpack the difference between lifespan and health span—because it’s not just about living longer, but living well. From cellular senescence to musculoskeletal strength, we look at ingredients leading wellness conversations and the future of longevity science. Neal also lifts the lid on supplement quality, why not all extracts are created equal, and explains the concept of bioavailability to actually move the needle. If you’re navigating perimenopause, curious about longevity, embarking on strength training, or trying to make sense of the supplement aisle, this episode will help you cut through the noise and make informed, future-focused choices. In partnership with Melrose Future Lab. Key Takeaways: Health span means more years lived well, not just longer Cellular senescence (aka “zombie cells”) reduces function as we age Berberine can support healthy blood glucose and AMPK activation Quality matters: not all herbal extracts or proteins are created equal Collagen, especially bovine-derived, supports muscle health Strength training is essential for bone density in menopausal women Supplement bioavailability is as important as the ingredients themselves Innovative formulations are changing how we absorb nutrients Menopause research is decades behind other women’s health areas Perimenopausal women benefit from tailored support and active nutrients Intermittent fasting and autophagy support cellular repair Effective supplements are about formulation—not fads Watch the full episode here: https://youtu.be/g1OFqhrIl1ISee omnystudio.com/listener for privacy information.

Join our free community, The Women's Peptide Collective, click the Skool link to become a member and to connect, learn, and collaborate. https://www.skool.com/womens-peptide-collective-9663Go to https://thepeptique.com/ to get all your research peptides .As a loyal listener use the discount code POD15 to get 15% off the entire line of products.Have questions? Feel free to reach out to me: tarawest@westwellnessatx.comWant the free peptide guide? Email me tarawest@westwellnessatx.com and comment Guide and I'll shoot it right over!Follow me on instagram AND TikTOk @westwellnessatxInterested in The Ultimate Energy Peptide Stack send me an email and I'll shoot it over to you! tarawest@westwellnessatx.comTakeaways: In reflecting upon my professional journey, I am immensely grateful for the support of my listeners. I have found that embracing failure is essential for personal and professional growth. The Ultimate Energy stack consists of NAD+, MOT C, and 5Amino 1 MQ, which promote cellular energy. It is crucial to understand that supporting NAD+ levels can enhance metabolic health and resilience as we age. MOT C activates AMPK, which encourages the body to efficiently utilize energy resources. 5Amino 1 MQ helps preserve NAD+ by blocking its diversion into waste, enhancing cellular energy production.

In this episode we dive into a hotly debated topic: should you eat meat or not? Ben is joined by two powerhouse guests with decades of experience in nutrition and health—Dr. Shawn Baker, best-selling author of The Carnivore Diet and leading carnivore advocate, and Joel Greene, creator of The Immunity Code and champion of dietary diversity. In this spirited debate, Dr. Baker highlights the benefits of a strict carnivore approach—meat, eggs, some dairy, and minimal plant foods—not only for himself but also for patients managing chronic health issues. He explains why animal-based nutrition can be so effective, breaks down the science of ketosis and gut health, and responds to concerns about long-term effects of fiber-free diets. Meanwhile, Joel Greene makes the case for dietary variety, drawing from evolutionary biology, clinical research, and personal experience. He explores the synergies of combining animal and plant foods, the role of fiber in gut and immune health, and the ancestral rhythms of scarcity and feasting. Joel argues that even small amounts of diverse foods can offset downsides of strict elimination diets. Dr. Baker is a physician, athlete, and author known for his straightforward, meat-focused approach to nutrition and his background in strength sports. Joel is the creator of Veep Nutrition, a program targeting gut communities to improve health, used by major employers and featured on the Dr. Phil Show. Author of The Immunity Code, Joel has devoted 50 years to health and anti-aging, pioneering practices like MCTs in the ’80s, keto in the ’90s, and AMPK activation by 2009. At 55, he remains a 100% natural athlete. Full show notes: bengreenfieldlife.com/diversityorcarnivore Episode Sponsors: Unmatched: Outlier by Unmatched is the world's first pre-workout featuring Paraxanthine instead of caffeine, delivering sustained energy and focus without the crash, plus premium ingredients like Cognizin for cognitive enhancement and NO3-T for incredible muscle pumps. Try it at unmatchedsupps.com/bengreenfield with special bulk discounts: 15% off one, 20% off two, or 25% off three. Xtendlife: Future-proof your health with Xtendlife’s Total Balance—100+ bio-active ingredients in a gender-specific formula designed for longevity and complete daily support. Use code BEN15 at www.xtend-life.com/ben for 15% off sitewide, plus free shipping. IM8: Ditch the cabinet full of supplements—IM8 packs 92 powerhouse ingredients into one delicious scoop for all-day energy, gut health, and cellular support. Go to IM8Health.com and use code BEN for an exclusive gift—fuel your body the right way! LMNT: Everyone needs electrolytes, especially those on low-carb diets, who practice intermittent or extended fasting, are physically active, or sweat a lot. Go to DrinkLMNT.com/BenGreenfield to get a free sample pack with your purchase! Ketone-IQ: Ketone-IQ delivers science-backed performance fuel that increases power output by 19%, reduces fatigue by 10%, and naturally boosts EPO production for better oxygen delivery—trusted by elite athletes like Jon Jones and Olympic champions. Save 30% on your subscription plus get a free gift with your second shipment at Ketone.com/BENG.See omnystudio.com/listener for privacy information.

TODO SOBRE TUS HORMONAS | CAPÍTULO 7 ¿Cómo modular tus hormonas a través de la nutrición? Tu cuerpo no funciona solo con calorías: funciona con señales. Cada alimento que comes manda un WhatsApp hormonal a tus células y glándulas. Según el mensaje, tu cuerpo activa rutas de construcción (mTOR), de ahorro y reparación (AMPK), o modula ejes clave como la tiroides, las suprarrenales y las hormonas sexuales. En este capítulo descubrirás: ✅ Cómo las proteínas encienden tu fábrica anabólica. ✅ Por qué los carbohidratos estratégicos no solo dan energía, también frenan el desgaste. ✅ Cómo las grasas de calidad son la materia prima de tus hormonas. ✅ El papel de los micronutrientes invisibles (zinc, magnesio, yodo, vitamina D, hierro…). ✅ Cuándo el ayuno es medicina y cuándo puede volverse veneno. ✅ La importancia del ritmo circadiano: no solo importa qué comes, sino cuándo lo comes. Mensaje clave: Tu plato programa tu sistema hormonal. No existe una dieta mágica: la magia está en entender cómo la comida habla con tus hormonas. Patrocinado por BeLevels Una marca española de suplementos que apuesta por la evidencia científica y patentes de primer nivel, de la mano del Dr. Antonio Hernández. Disfruta de un descuento exclusivo con el código PROFECLAUDIO en su web. Suscríbete al canal y activa la campanita para no perderte los próximos capítulos de la serie TODO SOBRE TUS HORMONAS. Sígueme en redes sociales para más contenido: @ProfeClaudio

Get My Book On Amazon: https://a.co/d/avbaV48Download The Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/1 On 1 Coaching Application: https://hunterwilliamscoaching.carrd.co/Book A Call With Me: https://hunterwilliamscall.carrd.co/Supplement Sources: https://hunterwilliamssupplements.carrd.co/Amazon Storefront: https://www.amazon.com/shop/hunterwilliams/list/WE16G2223BXA?ref_=cm_sw_r_cp_ud_aipsflist_R7QWQC0P1RACB2ETY3DYSocials:Instagram: https://www.instagram.com/hunterwilliamscoaching/Podcast: https://hunterwilliamspodcast.buzzsprout.com/Video Topic Request: https://hunterwilliamsvideotopic.carrd.co/In this video, I break down ATX-304 (also known as OS-01 or OS-03) — a powerful small molecule AMPK activator being studied for fat loss, metabolic health, and longevity. If you've heard ATX-304 described as “exercise in a capsule,” you'll see why after going through the research, mechanisms, human trials, and potential applications.I also share how ATX-304 works differently than GLP-1s, why it preserves muscle while supporting fat loss, and what the future may hold for this compound in anti-aging medicine.

GLP-1 agonists are transforming medicine in ways few could have predicted. In this captivating conversation, naturopathic physician Dr. Tina Moore challenges the conventional narrative around these medications, revealing their potential beyond weight loss and diabetes management.When Dr. Tina first began researching GLP-1s, she discovered a wealth of overlooked studies showing profound effects on inflammation, autoimmunity, and regenerative healing. Despite facing significant pushback from colleagues who expected a naturopathic doctor to reject pharmaceutical interventions, she couldn't ignore the compelling evidence. What she found most remarkable was how these peptides—which naturally occur in our bodies—could address multiple health issues simultaneously through their "pleiotropic" effects.The conversation ventures into territory rarely discussed in mainstream medical circles: how lower, personalized doses might provide optimal benefits while minimizing side effects. Dr. Tina shares striking clinical observations, including her own experience with Hashimoto's thyroiditis improving dramatically on a micro-dose regimen. Patients report unexpected improvements in conditions ranging from rheumatoid arthritis to depression to addictive behaviors—benefits that appear independent of weight loss.Most fascinating is Dr. Tina's perspective on dosing strategy. While conventional protocols typically start higher and escalate quickly, this approach risks receptor desensitization and excessive AMPK pathway activation, potentially causing disproportionate muscle loss. She advocates for "slow and low" dosing, tailored to individual needs, working alongside comprehensive lifestyle changes.The discussion also tackles accessibility issues, comparing compounded options with brand-name medications, and speculates about future developments that might make these treatments more affordable and personalized. If you're curious about metabolic health, inflammation, or the future of medicine, this conversation offers a refreshingly nuanced perspective that cuts through polarized debates with evidence-based insights.https://www.drtyna.com/https://www.gatlan.com/Lies I Taught In Medical School : Free sample chapter- https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (LUFKIN20 for 20% off) https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (20% off) https://siphoxhealth.com/lufkinMimio Health (LUFKIN for 15% off) https://mimiohealth.sjv.io/c/5810114/2745519/30611 Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmdInstagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/TikTok: https://www.tiktok.com/@robertlufkinThreads: https://www.threads.net/@robertlufkinmdFacebook: ...

Broadcast from KSQD, Santa Cruz on 9-11-2025: Dr. Dawn announces COVID-25/26 vaccines are now available at Safeway with same-day appointments, urging listeners to schedule quickly due to potential supply shortages amid uncertain federal vaccine policies. She discusses promising research on metformin for knee osteoarthritis in obese patients. Studies show metformin users lost half as much cartilage (0.75% vs 1.5%) over four years and had reduced knee replacement risk. The mechanism involves AMPK protein kinase pathways that reduce inflammation and cellular energy storage, with benefits independent of weight loss effects. Dr. Dawn warns hunters about blue pig meat from wild boars that consume rodenticide, which acts like warfarin to prevent blood clotting. The anticoagulant creates blue-tinted tissue that cooking cannot eliminate, making such meat dangerous for consumption during hunting season from September through November. She criticizes the elimination of women's health research funding, highlighting how the Eunice Kennedy Shriver Institute has advanced medical knowledge benefiting everyone. Dr. Dawn notes that $2.5 billion in research was rescinded for containing terms like "women" and "female," creating dangerous knowledge gaps when women experience different disease symptoms and medication responses than men. The brown rice versus white rice debate centers on arsenic content, with brown rice containing about 138 parts per billion compared to 93 in white rice. While both remain below WHO safety limits, children are especially vulnerable. Dr. Dawn recommends diverse grain options and specific cooking methods like soaking, rinsing, and using excess water to reduce arsenic levels. A caller asks about glutathione supplementation, specifically gamma-glutamyl cysteine products. Dr. Dawn explains how these precursors bypass liver metabolism to deliver glutathione to cells, while discussing the balance between oxidative and reductive stress. She notes individual genetic variations can affect supplement responses and emphasizes measuring markers rather than expecting immediate symptomatic improvements. Another caller inquires about histamine intolerance causing puffy eyes and food reactions. Dr. Dawn explains histamine's role as a neurotransmitter, sources in fermented foods and gut bacteria, and genetic enzyme deficiencies in DAO and histamine transferase. She recommends cromolyn sodium eye drops and systematic food elimination, particularly targeting recently increased consumption of chai tea and smoked brisket. Dr. Dawn concludes with news about an AI tool called FaceAge that predicts biological age and survival rates from facial photographs. Trained on 60,000 photos of people over 60, the system achieved 80% accuracy in predicting six-month survival for terminal cancer patients compared to 61% accuracy for human doctors, potentially offering a non-invasive health assessment tool.

Are you ready to finally break free from emotional debt and escape the patterns that are keeping you stuck? Josh Trent welcomes Jonny Miller, Nervous System Expert, to the Wellness + Wisdom Podcast, episode 769, to share why nervous system mastery is the missing key to true healing, how to rewire vagal tone capacity, how trauma gets stored in the body, why emotions travel across generations, and how breathwork and collective healing spaces help you reconnect with your true Self. Nervous System Mastery A 5-week live bootcamp to build calm, clarity, and resilience from the inside out. Most people think stress, burnout, and emotional patterns are “just the way life is.” But what if those patterns were actually shaping your biology and you had the tools to rewrite them? This training unpacks the science of how emotions, beliefs, and environment can switch genes on or off and shows you practical ways to reprogram them for peace, resilience, and lasting vitality. It's not about piling on more self-help. It's about learning how to create real inner safety, release stored trauma, and finally experience freedom in your body, mind, and spirit. Master Your Nervous System Today Enjoy $250 off the next cohort by using the link above or the code LIVEWELL In This Episode, Jonny Miller Uncovers: [01:15] Nervous System Mastery How the nervous system impacts our predictions. What made Jonny realize he was numb in his body. Why mastery takes at least 10,000 hours. How nervous system mastery means reducing reactivity. Why moments of crisis humble us and get us to start learning new ways of being. Resources: Jonny Miller Nervous System Mastery: $250 off using this link or with code LIVEWELL [06:20] Is Your Therapist Trauma-Informed? What it means when a practitioner is trauma-informed. How certain healing methods don't consider trauma. Why the wrong therapy can perpetuate trauma. How a good practitioner may take several years to become truly skilled at holding space. [07:55] Allow Yourself to Grieve What it was like for Jonny to grieve the loss of his partner. Why many people don't know how to grieve. How we resist the waves of grief. Why grief became the catalyst for Jonny's healing. Resources: [15:15] Do Emotions Get Stuck in The Body? The Body Keeps The Score by Bessel van der Kolk How anxiety is a defence strategy against feeling certain emotions. Anxiety: The Anxiety Cure for the Anxious Mind by Michael Johnson Vasocomputation Why the body constricts when it doesn't feel safe. How the body keeps the score. Resources: The Body Keeps The Score by Bessel van der Kolk Anxiety: The Anxiety Cure for the Anxious Mind by Michael Johnson Vasocomputation [18:45] How to Create Safety in The Body How the body makes prediction about the world. Why emotional releases create looseness and range of motion in the body. What it means to be safe in the body. Why nervous system mastery is about having a secure attachment with reality. [21:35] What's Blocking You from Joy How the one thing that all Blue Zones have in common is connection to a higher power. Why breathwork and plant medicine changed Jonny's view on life. How moving our beliefs out of the way allows us to experience pure joy. Why joy doesn't have to be earned. [26:30] Don't Let Fear Stop You from Healing How we can feel the emotions of our ancestors. What stops us from doing the deep healing work. Why protective mechanisms have a purpose in our lives. Resources: Parental olfactory experience influences behavior and neural structure in subsequent generations [30:20] Improving Your Vagal Tone Capacity Why the modes of reactivity are based on our vagal tone. How we can relax the hyperarousal state. Why vagal tone capacity allows us to stay grounded. How each of us has different capacity levels for each emotion. Why culture influences our capacity to feel and express our emotions. The difference between feeling and projecting emotions. [36:50] Is Your Relationship Toxic? Why people pleasing is a reflection of repressed anger. How relationships mirror how far we've come in the healing work. Why conflict has a purpose in a relationship. How intimate relationships are a fast track to nervous system mastery. When relationships become toxic. Resources: 738 How To Heal Generational Wounds Blocking Your Success + Self-Worth | John Wang 744 Debra Silverman | Your Pain Has a Pattern… and Astrology Reveals It All (This Isn't Random) 736 Silvy Khoucasian | Stop Confusing Chemistry for Trauma: Why You're Attracted to the Wrong People + How to Finally Break the Pattern [45:40] Outgrowing Your Partner What a relaxed nervous system feels like. Why we worship self-development. What happens when we outgrow our partner. [50:40] The Power of Breath Why most people breathe into the chest. How our breathing can cause a panic attack. Why we need to breathe into the lower diaphragm to feel more relaxed. How jaw tension is linked to lower body tension. Why we can change our state through our physiology. How we get out of tune as humans. Resources: Breath by James Nestor [56:55] How to Create a Space for Mastery How we can create an intentional space for mastery. Why we should avoid blue light in our space. Creativity is a blend of the ventral state and sympathetic state. How we can create a flow state. [01:00:25] Release Your Emotional Debt How Jonny helps his clients open their breathing. Why we need a dynamic range of breathing. How we can let emotions out through breathwork. Why emotional debt can kill us. How it becomes inefficient for the body to have many protective systems. Resources: 410 Mark Divine | Positive Neurodiversity: Kokoro Spirit, The 5 Mountains For Inner Peace, & How To Fulfill Your Potential [01:06:25] Collective Spaces for Healing How we're living in a sick culture that requires us to work towards health. Why we need collective spaces for emotional and ancestral healing. How men in Eastern Europe used to process their emotions in a sauna. [01:10:15] Your Money Starts with Your Body How tuning into our body helps us improve our relationship with our body. Why money is a mirror to our inner state. How we create stories around money. Why we can be scared to receive. [01:15:20] Are You Ready to Go on an Inner Adventure? How we're just understanding how our body work. Why the healing journey is an inner adventure. How we can achieve altered states through meditation. Why nervous system mastery is helping us remember and feel alive. Leave Wellness + Wisdom a Review on Apple Podcasts All Resources From This Episode Jonny Miller Nervous System Mastery: $250 off using this link or with code LIVEWELL The Body Keeps The Score by Bessel van der Kolk Anxiety: The Anxiety Cure for the Anxious Mind by Michael Johnson Vasocomputation Parental olfactory experience influences behavior and neural structure in subsequent generations 738 How To Heal Generational Wounds Blocking Your Success + Self-Worth | John Wang 744 Debra Silverman | Your Pain Has a Pattern… and Astrology Reveals It All (This Isn't Random) 736 Silvy Khoucasian | Stop Confusing Chemistry for Trauma: Why You're Attracted to the Wrong People + How to Finally Break the Pattern Breath by James Nestor 410 Mark Divine | Positive Neurodiversity: Kokoro Spirit, The 5 Mountains For Inner Peace, & How To Fulfill Your Potential Power Quotes From Jonny Miller "The nervous system is the lens through which we experience our life. The state of our nervous system impacts the predictions that we're making about the people and the world around us. And the work lies in identifying all of the ways in which we don't trust in ourselves or trust in life and then bring courageous curiosity towards those areas" — Jonny Miller "Any conflict is a potential edge to grow from. There's always going to be rupture in relationships. It's about how lovingly can you repair? How quickly can you go from conflict back to connection?" — Jonny Miller "We are in a world which worships self development. But there's a great distinction in self-development and self-unfoldment. When you're approaching inner work through the lens of self-developemnt, it often has this premise of part of me is broken and I need to fix it. Self-unfoldment, ot the other hand, starts with the premise of I am already whole and worthy of love." — Jonny Miller

Celebrities are ditching Ozempic after shocking side effects like nausea, fatigue, muscle loss, and even stomach paralysis. But what are they using instead?In this video, Dr. Anshul Gupta (Former Cleveland Clinic Functional Medicine Physician) reveals the secret supplement stack that mimics Ozempic's weight loss benefits naturally - without dangerous side effects.- Learn how Alpha Lipoic Acid, Fucoxanthin, Inulin, EGCG, and Berberine can help you lose stubborn belly fat, improve insulin sensitivity, and burn fat safely.- Get the exact supplement routine celebrities are using to stay lean without medications.- Discover how to combine supplements with the right diet and exercise plan for maximum fat loss results.What You'll Learn in This Video -- The dark side of Ozempic and why celebrities are abandoning it- 5 natural supplements that mimic Ozempic's pathways (GLP-1, AMPK, UCP-1)- How to stack these supplements for effective, sustainable weight loss- Dosages, timing, and practical daily routine- How to combine supplements with diet & exercise for best resultsBuy Anti- Inflammtory Bundle - https://functionalwellbeingshop.com/products/anti-inflammtory-bundleConsult Dr. Anshul Gupta from anywhere in the world for personalized, root-cause solutions to your thyroid and health concerns." link below for booking consultation.Work With Me -https://www.anshulguptamd.com/work-with-me/Don't forget to like, subscribe, and hit the notification bell for more health tips and treatments from Dr. Anshul Gupta.Take The Thyroid Quiz & Evaluate Your Thyroid Health -https://www.anshulguptamd.com/thyroid-quiz/To Buy Good Quality Supplements Goto -https://functionalwellbeingshop.com/To Buy Good Quality Supplements Goto (For India) -https://www.drguptafunctionalcenter.com/shop/Free Gift 3-day Mito-Thyroid Diet Meal Plan) -https://reversinghashimotobook.com/3-day-meal-planCheck Out More Useful Videos -#1 Habit To Get Rid Of Gut Inflammation (Don't Ignore) -https://youtu.be/0CoXDrgAFFk#1 Natural Remedy To Clear Mucus And Beat Allergies -https://youtu.be/dteX2hOjpBcConnect With Me -Instagram - https://www.instagram.com/anshulguptamd/WhatsApp - https://whatsapp.com/channel/0029VbAWez9HAdNSEf2Wse2rTwitter - https://www.twitter.com/anshulguptamdFacebook - https://www.facebook.com/drguptafunct0:00 - Celebrities & The Ozempic Weight Loss Hype1:30 - The Dark Side of Ozempic & Its Side Effects2:40 - Natural Supplement Stack: A Safer Alternative8:12 - Daily Routine: How to Use These Supplements9:29 - ConclusionFor personalized thyroid treatment plans and expertConnect With Me -Instagram - https://www.instagram.com/anshulguptamd/Twitter - https://www.twitter.com/anshulguptamdFacebook - https://www.facebook.com/drguptafunctPinterest - https://www.pinterest.com/anshulguptamdTo Buy Good Quality Supplements Goto -https://functionalwellbeingshop.com/Work With Me -https://www.anshulguptamd.com/work-with-me/Take The Thyroid Quiz & Evaluate Your Thyroid Health -https://www.anshulguptamd.com/thyroid-quiz/About Dr.Anshul Gupta MD -Dr. Anshul Gupta Md Is a Board-certified Family Medicine Physician, With Advanced Certification In Functional Medicine, Peptide Therapy, And Also Fellowship training in Integrative Medicine. He Has Worked At The Prestigious Cleveland Clinic Department Of Functional Medicine As Staff Physician Alongside Dr. Mark Hyman. He Believes In Empowering His Patients To Take Control Of Their Health And Partners With Them In Their Healing Journey.He Now Specializes As A Thyroid Functional Medicine Doctor, And Help People Reverse Their Unresolved Symptoms Of Thyroid Dysfunction.

Is your drive to achieve, please, or protect coming from a wounded part of you, rather than your true Self? Josh Trent welcomes Richard Schwartz, Creator of Internal Family Systems, to the Wellness + Wisdom Podcast, episode 767, to reveal why there are no “bad parts” within us, how trauma freezes pieces of our psyche in the past, and how to free yourself from legacy burdens passed down through generations. In This Episode, Richard C. Schwartz Uncovers: [01:10] What Is Parts Work? The definition of parts work. Why all parts of ourselves are valuable. How trauma freezes us in the past. Why we try to escape our parts to avoid feeling their pain. The role of exile and protector parts. How the firefighter parts try to get us away from our feelings to protect us. Resources: Richard C. Schwartz [07:45] The Difference Between Your Part and Your Self How each of us has an essence that is the Self. Why children take on different roles within their families to protect themselves. How we can heal the critic part. [13:40] Parts Work Isn't Inner Child Work Why thinking and feeling create different results. Why inner child work is not the same as parts work. How becoming the primary caretaker of our younger parts frees our partner from doing that for us. Resources: No Bad Parts by Dr. Richard Schwartz [17:20] Passive Vs. Active Parts Work How spiritual traditions teach how to observe our parts from a passive place. Why we're naturally inclined to listen to our parts as if they were our children. How 80% people who participate in plant medicine ceremonies tend to do the parts work after. The 8 C's of leadership. Resources: Michael Mithoefer MD [22:10] There Are No Bad Parts How Carl Jung impacted Richard's work. Why Carl Jung wasn't an active leader. How Richard used to believe some parts were bad. Why working with murderers and sex offenders showed him that there were no bad parts. How he had to work on a part of himself to turn judgment into compassion. Resources: Fritzi Horstman (Compassion Prison Project) [29:35] You Can't Save Your Parents How Josh healed a part of himself that needed to control others. Why some children feel the urge to save their parents. How we can show our younger self when they're stuck with our parents. Resources: 748 If Talk Therapy Worked, You'd Feel Better: New MDMA Therapy Breakthrough | Mike Zeller [32:30] Healing a Legacy Burden (Practical Exercise) Practical demonstration of how we can talk to our younger parts. Why Josh's younger part believed sex was bad and shameful. How legacy burdens are passed down from generation to generation. Why Josh learned from his dad what sex was.   [50:45] Are You a High Achiever? It Could Be Your Wound... Why we need to continue to have conversations with the parts we're healing. How Richard worked on his achiever part. Why we can turn our protector parts into parts that serve us. How 90% of all businesses and buildings built come from men trying to prove themselves to their fathers. Why healthy growth comes from the self. The importance of self-leadership in the evolution of the world. Resources: 503 Paul Levy | Wetiko: Break Free From Collective Mass Psychosis [59:55] The Rise of IFS Therapy Why Richard is asking for guidance from God. How he developed IFS while working in psychiatry. Why we can have entities attach to us that are not our parts. How he's trying to bring IFS to the culture. Resources: The Others Within Us by Robert Falconer [01:04:50] Evil Entities Don't Lie The difference between an entity and a part. Why evil entities don't lie. How psychedelics open the door for entities to attach to us. Resources: How to Achieve Inner Peace & Healing | Dr. Richard Schwartz on The Huberman Lab Podcast 692 Paul Chek | Spirit Gym: How To Find The Truth of Your Soul + Live Your Dream [01:08:10] Parts vs. Self How Richard's guides keep him humble about the work he's brought to the world. Why practitioners who don't have humility have the need for approval and praise. How some parts can imitate the true self. Why the self has a desire to bring healing without any agenda. How psychedelics, combined with IFS, bring back the self. [01:13:15] The Future of IFS Why it takes up to 7 years to become an IFS trainer. How many people nowadays teach an incomplete version of IFS. Why IFS brings light to the world. Resources: The Internal Family Systems Workbook by Richard Schwartz Leave Wellness + Wisdom a Review on Apple Podcasts

Text Dr. Black your questions or comments.Longevity Isn't Just About Living Longer—It's About Thriving As You AgeIn this empowering episode of Eat Your Greens, I break down six accessible habits that not only extend your lifespan but also improve your healthspan—the number of years you feel energetic, strong, and mentally sharp.These strategies aren't about perfection or extreme diets. They're rooted in solid science—covering pathways like AMPK, mTOR, telomeres, mitochondrial health, and cellular senescence—but translated into easy steps you can start today.

IQBAR is offering our special podcast listeners 20% OFF all IQBAR products, plus get FREE shipping. To get your 20% off, text VANESSA to 64000. That's VANESSA to sixty-four thousand. Message and data rates may apply. See terms for details. In this Part 2 solo recap episode, Vanessa Spina continues breaking down her powerful conversation with protein pioneer Dr. Donald Layman—covering the second half of their in-depth interview on metabolism, insulin resistance, muscle maintenance during menopause, and the launch of a groundbreaking new Protein Quality Hub. If you've ever wondered how to structure your meals to maximize fat loss, support lean mass, and protect your metabolic health as you age—this is the episode you've been waiting for.

In this Metabolic Classroom, Ben explores the fascinating metabolic effects of yerba mate, a traditional South American tea that's gaining attention in scientific circles. Yerba mate contains a synergistic mix of bioactive compounds, including xanthines (like caffeine), chlorogenic acid, and saponins—all of which contribute to its wide-ranging health benefits. Dr. Bikman explains how this unique brew supports fat loss, improves mitochondrial efficiency, regulates appetite, and enhances insulin sensitivity.Drawing from human and rodent studies, the lecture highlights yerba mate's ability to increase fat oxidation, particularly when combined with exercise. It also activates AMPK, a critical energy-regulating enzyme, which promotes glucose uptake and mitochondrial biogenesis. One of the most intriguing effects of yerba mate is its stimulation of GLP-1—both directly through the gut and indirectly by modifying the gut microbiome—making it a natural, non-pharmaceutical way to enhance satiety and insulin regulation.Dr. Bikman also discusses the underappreciated role of bitter taste receptors in the body—not just on the tongue, but also in fat cells and the gut. Yerba mate interacts with these receptors to influence hormone release (like CCK and PYY) and to promote thermogenesis in brown and beige fat, offering yet another pathway for metabolic support. Finally, he shares unpublished findings from his lab showing yerba mate's impact on hepatic redox balance, adding to its reputation as a powerful metabolic ally.Ben's favorite yerba mate and fiber supplement: https://ufeelgreat.com/usa/en/c/1BA884 Hosted on Acast. See acast.com/privacy for more information.

Thank you for listening to The Peptide Podcast. If you enjoyed the show and want to support what we do, head over to our Partners Page. You'll find some amazing brands we trust—and by checking them out, you're helping us keep the podcast going.  Today we're switching gears a bit to talk about a medication rather than a peptide — metformin. If you're someone who's interested in peptides for metabolic health or inflammation, you've probably heard metformin mentioned alongside them. It's been around for decades as a diabetes medication, but recently it's gaining attention for its potential benefits beyond blood sugar, including longevity, inflammation, and neuroprotection — even in people who don't have diabetes. Let's get into it. Metformin and Longevity Can metformin really help us live longer? One of the biggest sparks came from a 2014 study published in Diabetes, Obesity and Metabolism, where researchers found that diabetics on metformin actually lived longer than non-diabetics not taking the medication.  The authors suggested that metformin may offer protective benefits beyond glucose control, possibly by reducing oxidative stress and slowing cellular aging. This inspired the launch of the TAME trial—short for Targeting Aging with Metformin—which is designed to test whether metformin can delay the onset of age-related diseases like cancer, cardiovascular disease, and cognitive decline. While results are still pending, it's the first large-scale effort to study aging as a treatable condition, not just a process. Inflammation and Immunometabolism Next up: inflammation. Chronic low-grade inflammation is at the root of so many health issues—heart disease, dementia, even depression. Metformin appears to blunt systemic inflammation by activating AMPK. Think of AMPK as a metabolic master switch that lowers inflammatory signaling. A 2021 review published in Pharmacological Research found that metformin can inhibit NF-κB, a major pathway that drives inflammation. It also helped lower levels of CRP—a protein made by the liver that rises when there's inflammation from things like infection, injury, or chronic disease—and IL-6, another immune system protein commonly elevated in chronic inflammatory conditions. Because of these anti-inflammatory effects, researchers have been exploring metformin's potential in conditions beyond diabetes, including autoimmune diseases, multiple sclerosis (MS), PCOS, and even COVID—where it's been linked to lower mortality in patients with diabetes. Brain Health and Neuroprotection What about the brain? Can metformin help protect against cognitive decline? There's some promising data here too. A 2017 study in Aging Cell found that metformin improved neurogenesis in the hippocampus of aged mice—basically, helping old brains grow new neurons. In 2019 a cohort study in JAMA Network reported that people with type 2 diabetes taking metformin had a lower risk of developing dementia compared to those not taking it. Mechanisms may include reduced insulin resistance in the brain, less oxidative stress, and—again—AMPK activation, which promotes mitochondrial health and energy production. Still, human trials are mixed, and more controlled research is needed before we can call it a “smart drug.” Lower Cancer Risk So, here's an interesting one—can metformin actually lower the risk of cancer? Well, the short answer is: maybe. People with diabetes tend to have a higher risk of developing certain types of cancer, so part of metformin's benefit could just come from better managing blood sugar and insulin levels. But what's really exciting is that researchers think metformin might do even more than that. There's evidence suggesting it could have direct effects on cancer cells—like slowing down their growth or making the environment less friendly for tumors. Some studies have found lower rates of cancers like breast, colon, and prostate in people taking metformin. Now, this isn't a magic bullet or anything, but it's a promising area of research that's getting a lot of attention. So metformin might be pulling double duty: managing diabetes and potentially helping reduce cancer risk through other mechanisms we're still learning about. Metabolic Health for Non-Diabetics Now here's where it gets controversial—should healthy people without diabetes be taking metformin? Some researchers argue yes, especially for people with metabolic syndrome, prediabetes, or high inflammation. Metformin improves insulin sensitivity, reduces liver glucose production, and may even support modest weight loss. That said, there are tradeoffs. Metformin can cause stomach-related side effects (e.g., nausea, gas, heartburn, and diarrhea) and vitamin B12 deficiency (which may lead to nerve damage). It can also cause extreme fatigue.  Metformin may sometimes cause sexual side effects, like erectile dysfunction in men. Some studies suggest it might lower testosterone, which we know is important for male sexual health. But interestingly, other research points to metformin actually improving blood flow to the penis, which could help with erectile issues. So, it's a bit of a mixed picture—and it really depends on the individual. And although rare, it can cause lactic acidosis (a life threatening condition where lactic acid builds up in the blood) in older adults, people with advanced kidney disease, or those who drink excessive amounts of alcohol. So it's not a free pass.  So what are my final thoughts and who should you take metformin for longevity? Metformin isn't a one-size-fits-all solution, and it's definitely not something to start just because you heard about it on a podcast. We still need more research—especially in people without diabetes—to really understand who benefits most. But it might make sense for some people, like those with prediabetes, PCOS, metabolic syndrome, or even older adults looking to support healthy aging.  As always, it's something to talk through with your healthcare provider.  The science is exciting, but it's all about finding what makes sense for you. Thank you for listening to The Peptide Podcast. If you enjoyed the show and want to support what we do, head over to our Partners Page. You'll find some amazing brands we trust—and by checking them out, you're helping us keep the podcast going.  Until next time, be well, and as always, have a happy, healthy week.

Grab my FREE 4 Part Video Series: GLP1s Uncovered: https://bit.ly/GLP1uncovered EP 224: Today I'm diving into one of my greatest passions, coffee. Not just for the flavor or daily ritual, but because the science behind it is incredibly compelling. Often misunderstood and unfairly demonized in wellness circles, coffee is, in my view, one of the most powerful herbal medicines we have. Its benefits span brain health, metabolism, mood, cardiovascular support, and more. I'll break down the latest research on caffeine metabolism, including the key differences between slow and fast metabolizers, and how your individual response can impact sleep, blood pressure, and overall well-being. If you've ever questioned your relationship with coffee, or felt guilt-tripped into giving it up, this episode brings the data, context, and clarity you need to make your own informed choice. Check Out Kion Coffee - To save 20%, go to getkion.com/drtyna Topics Discussed: → Is coffee bad for your adrenal glands? → What are the health benefits of black coffee? → What's the difference between fast and slow caffeine metabolizers? → Does coffee improve metabolism and brain function? Sponsored By: → Check Out Kion Coffee - To save 20%, go to getkion.com/drtyna On This Episode We Cover:  → 00:00:00 - Introduction  → 00:08:01 - My go-to coffee order → 00:09:57 - Signs of slow caffeine metabolism → 00:13:01 - Ideal timing, dose, and nutrients → 00:18:11 - Heart, gut, and brain benefits → 00:24:36 - Mood, AMPK, and mTOR support → 00:26:40 - Adrenals, liver, and longevity → 00:29:52 - Metabolism and coffee → 00:31:39 - Research on aging and mortality → 00:35:51 - Why I choose Kion coffee → 00:39:27 - Coffee and mitochondrial health → 00:41:41 - Gut impact and inflammation → 00:44:31 - Dose-dependent effects → 00:48:28 - Filtered vs. unfiltered coffee → 00:50:36 - Mold & pesticides  Further Listening:  → Heart Health Playlist 

Unlock sharper focus and support long-term brain health with Ketone-IQ—clean brain fuel for deep work, mental clarity, and sustained energy with no crash. Get 30% off your subscription, plus a free gift with your second shipment at Ketone.com/vanessa. In Part 2 of this powerful interview, legendary protein researcher Dr. Donald Layman returns to the Optimal Protein Podcast to unpack some of the most misunderstood concepts in nutrition today—and to reveal potential groundbreaking changes to the U.S. dietary guidelines around protein, red meat, saturated fat, and carbohydrates. Dr. Layman breaks down what the science actually says about protein dosing, timing, oxidation, and muscle uptake—and who truly needs to worry about protein distribution. Vanessa and Dr. Layman also discuss:

IQBAR is offering our special podcast listeners 20% OFF all IQBAR products, plus get FREE shipping. To get your 20% off, text VANESSA to 64000. That's VANESSA to sixty-four thousand. Message and data rates may apply. See terms for details. In this Friday solo episode, Vanessa Spina breaks down the first half of her latest interview with Dr. Donald Layman — legendary protein researcher and one of the most featured guests in the history of the Optimal Protein Podcast. They cover game-changing updates to U.S. dietary guidelines, red meat's misunderstood role in metabolic health, and the science of protein timing for fat loss and body recomposition. Whether you're over 30, in a fat loss phase, or simply looking to optimize your protein intake, this episode is packed with insight.

Unlock sharper focus and support long-term brain health with Ketone-IQ—clean brain fuel for deep work, mental clarity, and sustained energy with no crash. Get 30% off your subscription, plus a free gift with your second shipment at Ketone.com/vanessa. This week on the Optimal Protein Podcast, I'm thrilled to be joined once again by Dr. Don Layman, one of the world's foremost experts in protein metabolism and amino acid science. In this first part of our two-part conversation, we take a deep dive into the true definition of protein quality, the flaws of current scoring systems, and the metabolic significance of leucine as a primary trigger for muscle protein synthesis. Dr. Layman also introduces the EAA-9 protein quality model, a new way of evaluating protein sources that takes into account the body's exact essential amino acid requirements—moving beyond methods like PDCAAS. Get 20% off on the Tone LUX Crystal Red Light Therapy Mask Ketogenicgirl.com with the code VANESSA We also discuss: Why protein quality should be defined by amino acid content, not nitrogen How leucine “shows up in nature” in exact ratios that muscle recognizes The four key signals muscle responds to: energy, leucine, insulin, and IGF-1 What activates and suppresses mTOR, and why AMPK shuts down MPS in low energy states How protein turnover drives up to 20% of your resting metabolic rate The concept of metabolic prioritization and what happens when your diet lacks adequate EAAs Why the term “protein requirement” is misleading—and why we actually have amino acid requirements Dr. Layman's response to the 100 g of protein study on protein distribution  A preview of what's really happening during fat loss, and how muscle preservation strategies can make or break long-term success This episode is a masterclass in muscle metabolism, protein science, and the tools you need to optimize your nutrition—especially for fat loss and body recomposition.

Healing isn't linear—and comfort is killing your progress. In this episode, we get real about why true metabolic flexibility (mTOR & AMPK), fasting vs. feasting, building muscle, electrolytes/hydration, and strategic protocols all demand seasons of intentional discomfort. We unpack the classic mistake: doing the right thing at the wrong time, wrong dose, or wrong order, and why your SIBO protocol, keto phase, or GI-MAP obsession didn't fix the terrain (liver, gallbladder, adrenals, stomach acid, biofilm, mold) that caused it. We also hit business, marriage, and mindset: new levels, new devils—and how to keep going when flares hit and faith is all you've got. *** Get Your Tickets Now: Use code REVIVAL for $100 discount ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠FitMom | UNSTUCK: The Women's Health & Hormone Summit⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ *** Gut & Hormones all messed up? ⁠⁠⁠➡️ Take the quiz⁠⁠⁠ ***

Welcome! And thank you for listening. Most of us prefer a steady path—training just enough, eating just enough, and aiming for just enough discomfort to grow without getting hurt. But real growth often lives at the edges—whether it's altitude, mileage, or life itself. That's where the lessons tend to be clearer, sharper, and sometimes, more painful. Today's podcast is about testing limits—about racing at 12,000 feet, facing unexpected setbacks, and learning the importance of mobility, preparation, and focusing on what we can control. We'll explore ATP, AMPK, how troubleshooting in training can prepare us for bigger goals ahead. It's about choosing to see challenges not as failures, but as valuable data on the journey to something greater. I hope you enjoy the listen.  If you would like to know more about our practice, please visit the website at https://doctordulaney.com/membership/join-us/ Email me  at jami@doctordulaney.com Nutrition consults: addie@doctordulaney.com Strength training: nathan@doctordulaney.com Book recommendation: The Happiest Man on Earth by Eddie Jaku Cookbook: https://a.co/d/6zVUluq Ebook: https://doctordulaney.com/powerful-plates-ebook/ Water distiller: https://mypurewater.com/?sld=jdulaney.  discount code cleanwaterforsophie

Story at-a-glance Used since 1406 CE in Chinese medicine, jiaogulan enhances stamina, lowers cholesterol, and supports metabolism, earning it the nickname “immortality herb” for its powerful benefits With an Oxygen Radical Absorbance Capacity (ORAC) value eight times higher than green tea, jiaogulan protects against cellular damage by neutralizing free radicals and reducing oxidative stress, which are key factors in aging and chronic disease Jiaogulan activates 5' adenosine monophosphate-activated protein kinase (AMPK), your body's energy switch, to enhance insulin sensitivity, block fat storage, and support cholesterol clearance — making it an effective ally in weight and blood sugar control This herb detoxifies the liver, improves circulation, and lowers inflammation through different flavor compounds, offering relief for conditions like fatty liver, high blood pressure, and chronic inflammation Studies show jiaogulan can shrink tumors, block cancer cell growth, and boost immunity — while sparing healthy tissue. Its natural compounds work across more than 30 cancer types, making it a promising adjunct therapy

In this episode of The Progress Theory, host Dr Phil Price invites physiologist and researcher Dr Tom Jones from Northumbria University to discuss the intricacies of concurrent training. They delve into the concept of the interference effect—a phenomenon where endurance training can attenuate strength gains—and explore how various training modalities, intensities, and volumes can be manipulated to minimize this effect. Dr Jones shares insights from his varied research experience across different sports, including his work with the Newcastle United Academy and the Swedish Winter Sports Research Center. The conversation touches on the real-world application of concurrent training principles, crucial mistakes to avoid, and the latest scientific understanding of acute molecular signalling. Whether you're a coach, athlete, or fitness enthusiast, this episode offers valuable knowledge on optimising concurrent training for peak performance. Join us for a deep dive into the science of training with Dr Tom Jones on The Progress Theory!In this episode, we discuss:00:00 Introduction03:51 Sports Research Journey Across Nations08:46 "Concurrent Training Challenge in Football"10:49 Concurrent Training: "It Depends" Dilemma13:00 Aerobic Volume Limits Strength Gains16:12 Interference Effect in Concurrent Training19:56 mTOR and AMPK in Concurrent Training25:53 Diet Control and Cycling Research28:23 Aerobic Training's Interference on Strength33:04 Managing Fatigue in Training Sessions35:58 Understanding Technical Training Challenges38:51 Concurrent Training Strategy OverviewTakeaways

This is a dive into research showing increased AMPK activation with low glycogen stores. We break down a paper discerning how AMPK does this, subsequent changes to AMPK's activity levels, and then come to some logical training conclusions. Along the way are some takeaways on interpreting and applying mechanistic research.

Dive deep into a transformative conversation as Josh Trent bares his soul, from overcoming childhood trauma and addiction to pioneering groundbreaking models for identity transformation. Interviewed by Human Design expert Emma Dunwoody, Josh unpacks the secrets behind resilience, authentic liberation, and the sacred interplay of money and spirit. Whether you're seeking practical wisdom, somatic insight, or a roadmap to break generational patterns, this episode delivers actionable breakthroughs to help you thrive on every level. In This Episode, Josh Trent Uncovers: [02:00] Personal Journey + Transformation Josh shares his transformative journey from addiction and personal struggles to becoming a wellness entrepreneur and podcaster. Raised by a bipolar mother and absent father, Josh fell into cycles of addiction (porn, womanizing). How he experienced his dark night of the soul in 2014 became the catalyst for authentic living. [09:20] Men's Mental Health + Emotional Intelligence Why there's an epidemic of male suicide and loneliness. How we're following outdated masculine norms. The purpose of strategic vulnerability. Why embracing feminine energy and emotional intelligence can become our core strength. [18:30] Podcast Evolution + Reinvention Why Josh rebranded the podcast from “Wellness Force” to “Wellness + Wisdom” in 2022 after a visionary mushroom journey with his fiancée. How he started podcasting a decade ago while $80K in debt; now approaching 800 episodes. How radical transparency and vulnerability drove exponential growth. [20:55] Human Design Integration How Josh distills universal wisdom. The importance of resilience through trial, error, and experimentation. Why it's Josh's entrepreneurial mission to guide humanity from survival into thriving. [26:55] Emotional Epigenetics Framework How unconscious beliefs, recurring emotional patterns, and environment shape our identity. Why our DNA expression is shaped via methylation. How trauma is inherited across up to seven generations. [31:30] The Wellness Pentagon + Authentic Liberation Five sides of the wellness pentagon: mental, physical, emotional, spiritual, and financial wellness. Why balanced nourishment acts like a “capacitor,” boosting life-force energy. How we can dismantle generational trauma and craft a liberated self-narrative. [36:35] Spiritual Relationship with Money How Josh evolved from a welfare childhood to viewing money as energetic love exchange. The difference between unconscious capitalism (self-serving) and conscious capitalism (community-serving). Why financial success is integral to modern spiritual practice. [01:10:50] Somatic Intelligence + Body Wisdom How the body detects truth or threat before the mind can process it. Why repressed memories surface only when we're neurologically ready to integrate them. The role of the body's protective intelligence in trauma healing. [01:21:15] Parenting + Generational Healing How Josh and his fiancée model emotional honesty and vulnerability. Breaking toxic family patterns by teaching children that honesty with others reflects inner integrity. Why parenting is a vital final step in halting trauma transmission.

Get My Book On Amazon: https://a.co/d/avbaV48Download The Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/

Get 40% Off At-Home NAD Shots Want a powerful energy boost without leaving home? Shed delivers clinical-grade NAD+ shots straight to your door—no appointment needed. NAD supports cellular repair, brain function, and longevity, making it one of our go-to biohacking tools. Get 40% off your first order at tryshed.com with code NURSEDOZA.     In this episode of the School of Doza podcast, we go full Cellular Energy 101: How to Improve Mitochondrial Function Naturally. Nurse Doza breaks down the five most impactful ways to boost energy from the inside out—starting with sunlight and ending with glutathione. If you're tired, sluggish, or just want to age better, this episode is your roadmap. 5 KEY TAKEAWAYS Sunlight—especially morning light—activates your mitochondria to naturally boost energy. Resveratrol supplements (like MITOCHONDRIAC) trigger AMPK, improving mitochondrial function. NAD+ injections can stimulate ATP production and mitochondrial biogenesis. Fasting and insulin regulation are essential for mitochondrial health and longevity. Glutathione protects your mitochondria from free radical damage and oxidative stress. FEATURED PRODUCT Mitochondriac, featuring pure trans-resveratrol and quercetin, is designed to activate AMPK and enhance mitochondrial function, promoting cellular energy production and healthy aging—exactly what's needed to implement the strategies discussed in this episode. Try Mitochondriac TIMESTAMPS 00:00 START – Welcome to the energy episode 05:00 – What mitochondria actually do (and why they matter) 07:00 – Energy vs waste: the balance of ATP and byproducts 08:00 – Why sunlight is your mitochondria's best friend 11:00 – Red light therapy and how it mimics the sun 12:00 – Resveratrol: how it fuels your cells 14:00 – The AMPK gene, explained simply 16:00 – Autophagy and mitochondrial biogenesis 17:00 – NAD+ therapy: weekly injections, daily energy 19:00 – The electron transport chain 101 22:00 – Mitochondrial enzymes that need NAD+ to function 24:00 – Regulating insulin and why fasting helps 27:00 – Ketones and caloric restriction for brain health 30:00 – The role of glutathione in detoxifying your cells 32:00 – Nurse Doza's 5-part mitochondrial optimization routine RESOURCES MENTIONED Red and Near-Infrared Light and Mitochondrial ATP/ROS Regulation NIR Light Reduces Cell Death in Parkinson's Disease Models Red Light Therapy and Mitochondrial Benefits Resveratrol and AMPK Activation Mitochondria, NAD+, and the Electron Transport Chain Ketones, BDNF, and Fasting Benefits Glutathione as a Mitochondrial Antioxidant SLC25A39 and GSH Transport into Mitochondria

What if true freedom demands separation from old beliefs? Josh Trent welcomes Preston Smiles, Abundance and Money Coach, to the Wellness + Wisdom Podcast, episode 752, to reveal how our need for external validation hijacks our true potential and abundance, what it really takes to break free from generational wounds, and why the commodification of spirituality will only be undone by uncompromising honesty and a relaxed nervous system. In This Episode, Preston Smiles Uncovers: [01:10] Why Most Self-Development Is “Blind Leading the Blind” Why healing doesn't have a hierarchy. How all fathers hold the hard things inside. Why nobody is better than anybody. What makes us chase the feeling of significance. How we're taught to seek validation outside of ourselves. Why most self-development is blind leading the blind. Resources: Preston Smiles 092 Now or Never: Alexi Panos & Preston Smiles [09:35] Being Honest with Your Children Why honesty is a gift to our children. How Preston's children witnessed a conflict between him and his wife. Why he apologized to his wife in front of his children after they had a fight. How being a demonstration is what lands the most for people. [13:00] How to Repair After Conflict Why God only hears 'yes.' How the body stores everything we've ever been through. What creates neurotags in the body. How not addressing our neurotags makes us harden. Why most of us didn't learn how to clear guilt, shame, and trauma from our body. The importance of having proactive practices to prevent disease. [18:30] The Role of A Father Why most of Preston's childhood friends didn't fulfil their potential because their fathers weren't present. How his father encouraged him to be a leader. Why most people don't have a father that's loving and present. Resources: Dead Poets Society (1989) [23:35] How to Be Free Why Preston quit being a reverend twice in his life. Science of Mind by Ernest Holmes The importance of questioning our answers. What is behind our belief that money is hard to come by. How questioning our path can set us free from generational wounds and beliefs. Resources: Spiritual Millionaire by Preston Smiles [29:00] Why Elevation Requires Separation How repair provides a space to ask each other questions. How we become like the people we spend time with. Why his wife was the first person Preston ever made love with. What led him to go deep into esoterics and conspiracies. [35:20] You Can Heal Yourself The difference between healthy and toxic fear. How Preston developed a skin disease and fell into shame when he was a teenager. Why he needed to process the abuse he went through as a child. How acknowledgment helped him heal. Why he did 31 ayahuasca ceremonies in a year. How people began to be part of Preston's healing. Resources: You Can Heal Your Life by Louise Hay [40:25] The Next Level of Law of Attraction The missing link to the law of attraction. Why the work is constant remembering of what is actually here. How learning to love what is opens up the door for us. Why we need to choose but not want. What we can't stop thinking about, it's our calling. How Preston connects with God. Why hearing God's voice when he was 15 saved his life. How he met his wife through listening and trusting God. Resources: The Secret by Rhonda Byrne 674 Daniele Kathryn Hage | Gender Equality vs. Gender Equity: How to Have a Lasting + Loving Relationship For Life [49:20] Healing Porn Addiction What made Josh realize that porn addiction was his own choice. How Preston approaches his children's sexuality. Why pornography is a tool of control. How he finally chose to see sex as a sacred act. [56:50] Is Demonic Energy Ever Good? How even demonic energy can serve us to awaken. Why the demonic energy is not the urge but the marketing machine that sold us the urge. How the bad things in our lives are our teachers on a soul level. [01:01:35] The Wounded Ego Why it's not our fault when we fall into addiction. How social media glorifies toughness. Why Preston's team didn't stop working when he decided to let them go. How he used to feel better than everyone. [01:08:05] How Much Money Do You Really Need to Be Happy? How Josh has worked through his relationship and money wounds to get where he is now. Why there is a point where money doesn't matter anymore. How Preston learned to appreciate his tiny apartment back in the day. Why get more if we can't love what we have now. How some rich people identify with the status of money and get controlled by it. Why Preston doesn't keep the things that make him attach to his ego. [01:14:45] Cheaters Don't Last How people have used Preston to climb the career ladder. Why his friend stole his workshop. How people who cheat other people don't last long in the game. Resources: Tai Lopez Grant Cardone [01:22:05] Spiritual Commodification Why the antidote to the commodification of spirituality is honesty. The importance of crediting those we've learned from. Why scarcity tells us there's not enough for everyone to share. How abundance comes from a relaxed nervous system. Why most people have a very small window of tolerance. Leave Wellness + Wisdom a Review on Apple Podcasts

In this episode, we delve into the fascinating world of C15, a newly recognized essential fatty acid, and its implications for longevity and health. Our guest, a leading expert in the field, Dr. Stephanie Venn-Watson shares her insights into the discovery and significance of C15, drawing connections between human health and findings from dolphin studies. Website - https://fatty15.com/JILLCARNAHAN  Key Discussions: ① The Discovery of C15:

Wellness + Wisdom: Liberated Life Series | Episode 749 Join Josh Trent, host of the Wellness + Wisdom Podcast, and Mar, co-host of the Liberated Life Series, as they shine a light on the shadow side of awareness, revealing why simply knowing what needs to change rarely ignites transformation. In this episode, they journey into the hidden inner-child wounds that shape our beliefs about worthiness and love, and share actionable insights for moving beyond awareness into genuine growth. We ALL have problems. Stop hiding. Start living life liberated. Learn how to set yourself free from self-sabotage, limiting beliefs, thoughts, and behaviors so you will have lifelong confidence and clarity of purpose through a thriving community and practical tools, guiding you to play a new reality game. Join Josh and others in the Liberated Life Tribe to: Discover lifelong confidence, clarity, and a true sense of purpose with practical tools and a supportive community. Learn to rewrite your reality + master a new “reality game.” Unlock your highest potential in your physical, mental, emotional, spiritual + financial SELF beyond your wildest dreams through accessing the power of surrender to trust life + create new results. Join the Tribe Today (It's FREE) Listen To Episode 749 As Josh Trent Uncovers: [00:00] Understanding Awareness vs. Action The disconnect between knowing and doing Why awareness alone isn't enough to create change Mar shares her personal struggle with social media addiction Why we struggle to implement the practices that we know would help us How biological trust must align with conscious knowledge [04:00] Parts Work Exercise (IFS) Josh guides Mar through connecting with her inner child part named 'Maky' (age 12-13) Maky reveals she believes she must 'prove herself to be worthy of love' The inner child expresses discomfort with receiving love, as it feels unnatural Josh helps Mar establish a gentle connection with this part of herself Maky shares that all she ever wanted was love, but doesn't know how to trust [11:55] Healing Through Connection Maky agrees to 'come along' with adult Mar on her life journey Mar acknowledges the paradox of wanting love while being afraid to receive it Mar understands that her parents weren't bad people, but struggled to express love in ways she needed Josh notes how this inner child connection is the missing piece between awareness and action The exercise reveals how external behaviors (like social media scrolling) are clues to deeper emotions [24:25] Integration + Transformation Why awareness isn't about 'fixing' but about loving ourselves into trusting life again How emotional patterns get passed through epigenetics Why awareness is just a guidepost leading to deeper understanding The ultimate goal is liberation through genuine peace and trustworthy power Leave Wellness + Wisdom a Review on Apple Podcasts

Welcome back to the Longevity Podcast! I'm so excited for today's episode, where I sit down with Chris Rhodes—nutritional biochemist, fasting researcher, and CEO of Mimio Health—to dive deep into one of the most fascinating emerging topics in longevity science: fasting mimetics. If you've ever wanted to get the regenerative, anti-inflammatory, and health-boosting effects of fasting, but struggled to actually fast for 36 hours or more (trust me, I get it!), this conversation is for you. Listeners of this podcast can visit mimiohealth.com/nat and use code NAT FOR 20% off your first single purchase or subscription order.   What we discuss: Meet Chris Rhodes and his biomimetic research journey ... 00:05:18 Unlocking fasting benefits without prolonged fasting ... 00:09:10 Supplements vs. pharmaceuticals for longevity ... 00:10:53 Fasting protocols, timing, and metabolic switching ... 00:15:23 Risks of fasting, evolutionary adaptation, and muscle/bone loss ... 00:18:34 Ketones, brain energy, and cognitive adaptation ... 00:22:48 How fasting activates longevity and repair pathways ... 00:26:23 Key cellular pathways: AMPK, mTOR, NAD, sirtuins ... 00:28:04 Mimio research: discovering and testing fasting metabolites ... 00:33:35 The four main fasting mimetic molecules explained ... 00:42:04 Practical benefits: who should use fasting mimetics & safety ... 00:59:00 Mimio in use: hunger control, GLP-1 support, and older adults ... 01:03:37   Our Amazing Sponsors: Qualia NAD+ - This vital molecule powers cellular energy, supports DNA health, aids detox, and helps keep your body remain youthful. Visit qualialife.com/nathalie to try Qualia NAD+, backed by a 100-day money-back guarantee, and use promo code NATHALIE for 15% off! OraltidePro - A unique mouthwash that: Promotes growth of shrinking gums, Speeds healing of mouth & tongue, Prevents oral infections (such as gingivitis), Helps with enamel remineralization, Reduces bacteria growth and etching and Fills slots in damaged enamel. Check out OraltidePro at profound-health.com and use code NAT15 for 15% off your first order. Bio-Shield by Young Goose - A broad-spectrum serum that protects against UVA/UVB, infrared, AND high-energy visible (HEV) light. Visit YoungGoose.com—use code NAT10 to get started, or 5NAT if you're an existing customer.     More from Nat:  YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

Wellness + Wisdom: Liberated Life Series | Episode 747 Wellness + Wisdom Podcast Host, Josh Trent, shares the top 10 things that changed his life and led him on a deeper journey of self-discovery and transformation. He explores the profound impact of breathwork and conscious relationships, revealing how these practices can unlock emotional freedom and inner peace. We ALL have problems. Stop hiding. Start living life liberated. Learn how to set yourself free from self-sabotage, limiting beliefs, thoughts, and behaviors so you will have lifelong confidence and clarity of purpose through a thriving community and practical tools, guiding you to play a new reality game. Join Josh and others in the Liberated Life Tribe to: Discover lifelong confidence, clarity, and a true sense of purpose with practical tools and a supportive community. Learn to rewrite your reality + master a new “reality game.” Unlock your highest potential in your physical, mental, emotional, spiritual + financial SELF beyond your wildest dreams through accessing the power of surrender to trust life + create new results. Join the Tribe Today (It's FREE) Listen To Episode 747 As Josh Trent Uncovers: [01:30] Breathwork as Foundational Practice Why breath is the most transformative tool that helped Josh with his personal struggles with addiction. Breathwork is both a voluntary and involuntary lever for the autonomic nervous system, impacting vagal tone and overall well-being. The journey of studying breathwork to launch BREATHE: Breath + Wellness Program in 2020. [02:45] Parts Work Why parts work is crucial for understanding and integrating inner child and protector dynamics. How the method is integrated into the Emotional Epigenetics L.I.F.E. Method program, focusing on nervous system trust and self-acceptance. [03:55] Conscious Relationship Why conscious relationships are powerful catalysts for personal growth, ego dissolution, and healing generational wounds. How the soulmate's prayer helped Josh find his partner. The importance of soul unions in triggering and healing deep-seated issues. [05:10] Letting Go of Pornography How pornography is normalized by our society. Addiction is reframed as a symptom of disconnection from self and others, with freedom found in truth and self-honesty. The importance of identifying and addressing our addictions. [08:05] Influence of David Hawkins + Alan Watts The role of David Hawkins' frequency scale. How the teachings help bridge the gap between mind and heart, and shape the Emotional Epigenetics methodology. The importance of feeling and integrating emotions for personal growth. [09:30] Mindful Language + NLP Why words are spells. How NLP (Neuro-Linguistic Programming) serves as a tool for self-programming and transformation. The importance of replacing negative self-talk with empowering language to transform our nervous system and mindset. [12:30] Brotherhood + Men's Work The value of men's groups and brotherhood is discussed, highlighting the importance of being witnessed and supported by other men. Why men's groups are a space for sharing, questioning, and impact without coaching, fostering authenticity and emotional release. [14:00] Wellness Care Routine Why wellness routines (stretching, reading, sauna, cold plunge) are essential for anchoring peace and supporting epigenetic health. The importance of committing to one wellness ritual and building consistency before adding more. [16:25] Plant Medicine (Caution + Wisdom) Why plant medicine is transformative but potentially risky if approached with the wrong intention or in excess. How plant medicine allowed Josh to face his pornography addiction. The importance of respect, intention, and integration in using plant medicine. [19:05] Fatherhood Fatherhood (or motherhood) is the greatest teacher, expanding capacity for patience, forgiveness, and presence. How imperfect but present parenting with inner child work can deepen the connection to our children. Leave Wellness + Wisdom a Review on Apple Podcasts

Can we really reverse biological age?  In this groundbreaking episode, I sit down with Greg Macpherson, biotechnologist, pharmacist, and founder of SRW Laboratories, to explore the cutting-edge science behind reversing biological ageing — backed by real human clinical trial data. We discuss SRW's latest clinical study, which demonstrated measurable reductions in biological age markers through targeted supplementation. Greg unpacks how biological age is assessed using epigenetic markers like DNA methylation, and how SRW's formulations are designed to influence key aging pathways including: sirtuins, NAD+ production, AMPK, and mTOR modulation. What you'll learn from the episode:  What biological age really means  How SRW's trial measured age reversal using TruDiagnostic epigenetic clocks  Key molecules and compounds driving the effect  The importance of cellular senescence, mitochondrial function, and genomic stability  What's next in the field of longevity biotechnology Whether you're a health professional, biohacker, or longevity enthusiast, this episode is packed with science-forward insights and actionable takeaways. Shop SRW supplements here: SRW Supplement Range  Follow Greg Macpherson: Linkedin/Greg Nacpherson SRW  Explore epigenetic testing: Trudiagnostic - TruAge COMPLETE Greg Macpherson: Throughout my career, I have been driven by a desire to help people achieve their potential by overcoming health challenges. As a biotechnologist, futurist, author, and pharmacologist, I have pursued this goal by founding one of the first online pharmacies in New Zealand and creating the country's first Government licensed robotic dispensing facility. My current focus is on understanding cellular aging and developing new formulations to support healthy aging and improve human health. For the past 10 years, I have been researching cellular aging and consulting with global experts in the field. All of this research and experience has led me to establish SRW, an organization that aims to translate scientific advancements into practical solutions for everyday people to live longer, healthier lives.  

Wellness + Wisdom | Episode 746 Are you ready to reconfigure your past and reimagine humanity's future through the power of outrageous love? Visionary Philosopher Marc Gafni joins Josh Trent on the Wellness + Wisdom Podcast, episode 746, to guide you from mythic narratives of soul mates to the co-creative vision of whole mates: evolutionary partners in service of the cosmos. Learn how the gift of suffering becomes the pathway to transcendence, why raising children is a spiritual act of embodiment, and how solving humanity's value crisis can spark a galactic awakening. "Soulmate relationships don't work. They're insufficient. If a couple is not looking at a shared horizon and they are only looking deeply in each other's eyes, it will not work. Whole mates are not just looking deeply in each other's eyes. They're first looking at a shared horizon, a shared mission. They're looking at the whole. They're in a relationship to the whole. And then from there, they turn back and look at each other." - Marc Gafni In This Episode, Marc Gafni Uncovers: [01:20] Outrageous Love Marc Gafni Why 'I love you' is our sacred creed. How facing death puts us in our visceral truth. Why we've lost connection to the meaning of 'I love you.' The difference between ordinary love and outrageous love. How love allows us to give our unique gifts. When we're in love, we feel welcome in the cosmos. Why reality is not a fact but an outrageous love story. How reality is generated. [09:50] What Is Evolution? Whole Mate by Marc Gafni The three levels of knowing. How we get lost in the complexity, which blocks us from seeing the depth. Every place we've been, we needed to be. Why every detour is part of the destination. How reality has mathematical, musical, molecular, metabolic, moral, and mystical values. Why reality is movement towards transformation. Evolution is love in action in response to need. How becoming what reality intended us to be, divinity experiences self-recognition through us. If we don't have the experience that we matter, our mind, heart, and body break down. [20:20] The Three Faces of God Why the God we don't believe in doesn't exist. The importance of the word 'God.' Why outrageous love is not a response to another person but the love that moves through us. The three faces of God: first, second, and third person. Neil deGrasse Tyson How religions show the faces of God. [29:50] New World Why we're in a time between worlds. How 40% of AI researchers believe that AI could destroy all humanity. 692 Paul Chek | Spirit Gym: How To Find The Truth of Your Soul + Live Your Dream How we can create a new story of values for the world. [35:45] Divine Loneliness Why God is lonely. How we need separation to create intimacy. What it means to be lonely. How Marc's son made him see the human singularity. The importance of knowing our soul print. How we cover up our emptiness by getting our attention hijacked. Why we need to sit in loneliness in order to fill up with our soul print. The divine is being, spaciousness, and becoming. Why evolution is a love story of the universe. How wholeness comes from brokenness. [47:25] Pseudo-Eros + Shame Why pornography is pseudo-Eros. How pornography is explicit sexuality taken out of the context of a story. Why our relationship to essence is always sensual. How our shame tells a story that we're wrong. Why a great saint makes new mistakes. The meaning of the word 'hallelujah.' [56:10] From Soul Mate to Whole Mate Why soulmate relationships don't work. Evolution of Love from Quarks to Culture by Marc Gafni, Zak Stein + Elena Levin Why reality is evolution, relationships, and the evolution of relationships. How crisis drives evolution, and the movement is an evolution of relationships. The evolution from role mate to soul mate to whole mate. The Boy Crisis by Warren Farrell + John Gray How each one of us has a role within a relationship in order to survive and thrive. Love Story (1970) [01:11:50] How Movies Tell The Story of Reality How the Matrix movie displays a whole mate relationship. The 5 Love Languages by Gary Chapman Why Mars and Venus Collide by John Gray Getting The Love You Want by Harville Hendrix How love replaced our values. Why sexuality is not personal but universal. The importance of having a shared vision as a couple. Social Physics by Alex Pentland Why most children don't believe in love anymore. Sapiens by Harari Yuval Noah [01:30:35] Raising Children As Whole Mates 744 Debra Silverman | Your Pain Has a Pattern… and Astrology Reveals It All (This Isn't Random) What embodiment feels like. Why raising children is more than a role mate part. How we can serve the larger whole. Phenomenology of Eros by Jonna Bornemark + Marcia Sa Cavalcante Schuback The reason why most relationships don't work. Why monogamy is a practice. Why relationships are the basic structure of reality. How most couples therapists don't address the issue of not having a shared vision. [01:42:15] Our Deepest Desires Our Divine Desires Why God is the intimate infinite. How creating a new intimacy creates a new God. Why spirituality and religion must come together. How our desire to become more intimate comes from God. [01:48:55] The Purpose of Evolution Why the purpose of evolution is the evolution of love. How the evolution of love is the evolution of God. Why whole mates are evolutionary partners. An atom is a new value of intimacy. How we move from matter to life. Why power gives us pleasure and dignity. How we can impact the whole world. Why we're never powerless. Enlightenment means to know the nature of reality. [01:58:55] Reconfigure Your Past What creates a capacity to transform. How we can get beneath time. Why we can undo our mistakes. How transforming our will transforms our deeds. [02:07:10] New Humanity + Existential Risks How we can practice love in the moments of pain. Why the universe feels love. How outrageous lovers commit outrageous acts of love. Why war is not inevitable. We can create a new human and a new humanity. How the cosmos is moving towards more goodness. What existential risks we're facing as humanity. Reimagining Humanity's Identity: Responding to the Second Shock of Existence by Marc Gafni + Zachary Stein Why evolution doesn't stop. [02:17:05] Solving Value How the process of getting deeper is our joy. First Principles and First Values by David J. Temple Why there are different qualities of love. How the new age community doesn't do the deep work. Why we need to solve the value to create a change in the world. [02:25:30] What Is Value? How the source code is corrupted because the story of value has gotten lost. Why we need to go to the source code to clarify our values. What makes us question ourselves. How reality desires to evolve the source code. Why we're on the edge of a galactic moment. Avatar (2009) Leave Wellness + Wisdom a Review on Apple Podcasts

Explore the science behind the "Sugar Diet," a low-protein, high-carbohydrate or high-fat dietary regimen. We'll discuss how this approach influences metabolic pathways, its potential benefits for fat loss, and the importance of nutrient quality in achieving optimal health outcomes. All things considered, do we recommend anyone utilize this strategy? Tune in to find out! APPLY FOR COACHING: https://www.lvltncoaching.com/1-1-coaching SDE Method app: https://www.lvltncoaching.com/sde-method-app Macros Guide https://www.lvltncoaching.com/free-resources/calculate-your-macros Join the Facebook Community: https://www.facebook.com/groups/lvltncoaching FREE TOOLS to start your health and fitness journey: https://www.lvltncoaching.com/resources/freebies Alessandra's Instagram: http://instagram.com/alessandrascutnik Joelle's Instagram: https://www.instagram.com/joellesamantha?igsh=ZnVhZjFjczN0OTdn Josh's Instagram: http://instagram.com/joshscutnik ‍ Timestamps: 00:00 Introduction and Birthday Celebrations 02:57 Understanding the Sugar Diet 05:58 The Science Behind Low Protein Diets 09:56 Critique of the Sugar Diet 12:43 Metabolic Health and Individual Responses 15:51 Long-term Implications of the Sugar Diet 18:50 Conclusion and Final Thoughts 23:38 The Impact of Diet on Health 25:38 Understanding mTOR and AMPK 26:33 Taurine and Its Role in Diet 27:28 The Efficiency of Low Protein Diets 29:24 The Nuances of Dietary Strategies 30:17 Target Audience for New Diets 31:42 The Risks of Misleading Headlines 33:30 The Importance of Metabolic Health 34:46 Navigating the Health and Fitness Industry 36:34 Exploring Nutrient-Dense Carbohydrate Sources 38:24 Limitations of Low Protein Diets 40:11 Long-Term Effects of High Sugar Diets 42:25 Key Takeaways and Recommendations

I’m joined by Neal Mercado, Chief Science Officer at Melrose, one of Australia’s leading wellness brands and the team behind Melrose Future Lab. Neal leads a thought-provoking conversation on ageing, vitality, and the science behind what really works. We unpack the difference between lifespan and health span—because it’s not just about living longer, but living well. From cellular senescence to musculoskeletal strength, we look at ingredients leading wellness conversations and the future of longevity science. Neal also lifts the lid on supplement quality, why not all extracts are created equal, and explains the concept of bioavailability to actually move the needle. If you’re navigating perimenopause, curious about longevity, embarking on strength training, or trying to make sense of the supplement aisle, this episode will help you cut through the noise and make informed, future-focused choices. In partnership with Melrose Future Lab. Key Takeaways: Health span means more years lived well, not just longer Cellular senescence (aka “zombie cells”) reduces function as we age Berberine can support healthy blood glucose and AMPK activation Quality matters: not all herbal extracts or proteins are created equal Collagen, especially bovine-derived, supports muscle health Strength training is essential for bone density in menopausal women Supplement bioavailability is as important as the ingredients themselves Innovative formulations are changing how we absorb nutrients Menopause research is decades behind other women’s health areas Perimenopausal women benefit from tailored support and active nutrients Intermittent fasting and autophagy support cellular repair Effective supplements are about formulation—not fads Chapter: 00:00 – The Importance of Health Span vs Longevity03:05 – Understanding the Hallmarks of Ageing05:58 – Cellular Mechanisms of Ageing and Longevity09:12 – The Role of Supplements in Ageing Well11:59 – Berberine: A Key Player in Longevity15:02 – Navigating the World of Supplements18:02 – The Future of Health and Wellness26:32 – Musculoskeletal Health and Ageing34:00 – Innovations in Formulation and Bioavailability38:01 – Addressing Menopause and Perimenopause45:23 – The Importance of Formulation Over Ingredients Watch the full episode here: https://youtu.be/i65uno_HZQoSee omnystudio.com/listener for privacy information.

In this solo episode of The Red Light Report, Dr. Mike explores the profound connection between mitochondrial health and oral disease. He reviews three recent studies highlighting how red light therapy, methylene blue, and compounds like urolithin A can support oral tissues, reduce inflammation, and even impact systemic conditions like diabetes and neurodegeneration. From root canal innovations to mitophagy in periodontitis, this episode is full of cutting-edge insights and practical applications for anyone interested in longevity, biohacking, or oral health optimization.Key Topics Covered:Study #1: Methylene Blue + Graphene Oxide for Root Canal Photodynamic Therapy• Combining methylene blue and reduced graphene oxide with red light therapy significantly improves antibacterial and antifungal effects in root canals.• Highlights the synergy between methylene blue and red light.• Dr. Mike shares how his nighttime routine—using BioBlue Calm and a red-light toothbrush—may create a low-level photodynamic therapy effect in the mouth.Study #2: Mitophagy in Periodontal Disease• Mitophagy (mitochondrial autophagy) plays a key role in managing inflammation, bone remodeling, and cell death in gum disease.• Key interventions to enhance oral mitophagy:• Urolithin A (strong Pink1/Parkin pathway activator)• Resveratrol, Melatonin (support mitochondrial quality)• Berberine, Curcumin, Metformin (via AMPK activation)• NR, Quercetin (via SIRT1 + PGC-1α pathway)Study #3: Mitochondrial Dysfunction Links Oral and Systemic Diseases• Periodontitis driven by mitochondrial dysfunction is linked to diseases like diabetes, cardiovascular disease, and neurodegeneration.• Key issues:• Impaired mitochondrial fusion/fission, biogenesis, and mitophagy.• Excessive ROS and mitochondrial DNA leakage fuel inflammation.• Poor mitochondrial function impairs periodontal stem cell regeneration.• Therapeutic approaches:• Antioxidants (CoQ10, resveratrol, melatonin, curcumin, EGCG)• Photodynamic therapy (methylene blue + red light)• Mitochondria-targeted compounds to modulate apoptosis and inflammation.Dr. Mike's Takeaways• Oral mitochondrial health is foundational—not isolated from systemic health.• Red light therapy and methylene blue offer powerful synergistic effects, even in oral applications.• A mitochondria-first approach may provide long-term protection against oral and systemic disease.   If you found the information in today's episode particularly interesting and/or compelling, please share it with a family member, friend, colleague and/or anyone that you think could benefit and be illuminated by this knowledge. Sharing is caring :)As always, light up your health! - Key points: 00:00 – Introduction: Mitochondrial Health & Podcast Focus 00:32 – Announcements: Health Alchemy Bundle & Upcoming Events 06:18 – Study 1: Methylene Blue & Red Light Therapy for Root Canal Treatment 08:42 – Methylene Blue Benefits Recap 13:37 – Study 1 Discussion: Photodynamic Therapy Enhancements 16:57 – Practical Application: Methylene Blue for Oral Health 19:40 – Study 2: Mitophagy in Periodontal Disease 23:46 – Targeted Mechanisms to Enhance Mitophagy 28:42 – Study 3: Mitochondrial Dysfunction in Periodontitis & Systemic Diseases 31:38 – Therapeutic Strategies for Mitochondrial Health 41:44 – Integrative Mitochondrial Therapies 47:02 – Conclusion: Mitochondrial Dysfunction as a Core Issue 50:45 – Closing Thoughts & Upcoming Events - Articles referenced in episode:Synthesis, characterization, and application of methylene blue functionalized reduced graphene oxide for photodynamic therapy in root canal treatmentMitophagy and Its Significance in Periodontal DiseaseMitochondrial Dysfunction in Periodontitis and Associated Systemic Diseases: Implications for Pathomechanisms and Therapeutic Strategies - Get over $6,000 worth of wellness education from top experts for $50! The Health Alchemy BundleThis is an amazing opportunity put together by Carrie Bennett and Sarah Kleiner! This Bundle is collection of 60+ eBooks, courses, and other resources available for $50 at a mind-blowing 99% discount.     This massive collection of resources is rooted in the science + spirituality of healing with nature, which cover topics like: Circadian & quantum biology Mental, emotional, & spiritual health Nutrition, minerals, & supplementation (when necessary) Herbalism & homeopathy Movement, posture, & fitness Hormonal health, pregnancy, & parenting And even specific issue support—from healing autoimmunity to improving sleep, & more This is a limited opportunity that goes through TOMORROW, May 23rd, so act now and don't miss out!   Get The Health Alchemy Bundle by clicking here! - Upcoming BioLight Events:   Biohacking Conference - May 28 - 30 (Austin, TX)   Returning to Nature (Quantum Health Retreat), June 26 - 27 (Franklin, TN) - Introducing the Newest BioBlue Supplement! The most comprehensive, powerful mitochondrial support supplement on the market ...   What is The Fountain of Youth in simple terms? An unparalleled supplement for brain power, energy, and longevity This supplement is like a high-performance tune-up for your brain and body. It combines powerful natural and science-backed ingredients to help you think clearer, feel more energized, and support your long-term health.The BioBundle automatically saves you 15% on both of the supplements you choose.   For the next two weeks, SAVE 20% on your order of BioBlue Fountain of Youth! Simply use code FOY20 Code expires 5/29, midnight PST   Click here to check out BioBlue Fountain of Youth - Dr. Mike's #1 recommendations: Water products: Water & Wellness Grounding products: Earthing.com EMF-mitigating products: Somavedic Blue light-blocking glasses: Ra Optics - Stay up-to-date on social media: Dr. Mike Belkowski: Instagram LinkedIn   BioLight: Website Instagram YouTube Facebook

Wellness + Wisdom | Episode 742 Is your fear of suffering keeping you from discovering the deepest treasures of your soul? Author and extreme adventurer, Akshay Nanavati, joins Josh Trent on the Wellness + Wisdom Podcast, episode 742, to share how embracing suffering during his 60-day solo crossing of Antarctica became the key to transcending limitations and unlocking pure potential, what his journey taught him about the paradox of oneness, and why the only way out of suffering is through it. "When you stop resisting suffering, it frees you from the grasp of suffering. It's not the suffering in and of itself that I seek. Suffering is the means, not the purpose. The purpose is what it gives you access to. It's the transcendence, the awakening, the breaking down of the illusions, the surrender." - Akshay Nanavati In This Episode, Akshay Nanavati Uncovers: [01:10] 60 Days Alone in Antarctica Akshay Nanavati 606 Akshay Nanavati | How To Love Your Fear: The (REAL) Secret To Unlocking Your Pure Potential How the world shows you more about the human soul than any textbook. Why it's a privilege when we can choose our suffering. How he confronted his inner demons while crossing Antarctica. Why Akshay's biggest mental challenge during the expedition was frustration. How the last 10 days felt like he was drunk. Why he ended the expedition after 60 days due to a life-threatening medical issue. [08:45] How to Stay In The Present Moment What brought Akshay into moments of oneness and bliss during the expedition. The three elements of a raw experience. Why he was pushing himself back into the present moment in order to keep going. How the only thing he could control was his next step. [12:40] The Paradox of Oneness How we all seek different forms of peak experiences. Why the illusion in which we experience life changed for Akshay. Fearvana by Akshay Nanavati How the opposites encompass the human experience. Why the mind creates an illusion of good and bad. How Antarctica made Akshay feel very small but also extremely powerful. Why love is an experience of both separation and connection. How resisting or clinging to duality creates suffering. [19:40] The Gift of Suffering The bigger the dragon we battle, the better the treasure on the other side of the battle. Why the human experience is a paradox. How suffering is the means to transcendence. Why pain connects us to God. How Akshay accepts what is instead of resisting suffering. Why comfort is not the enemy. [26:45] Pure Experience Why reality is not "either, or." How labels create divisions and limitations. Why words can open the door for us, but can't provide the same value as experience. How mastery is about bringing ourselves back to the center. [31:40] Stop Attaching to The Outcome How Akshay's Antarctica crossing helped him shed the resistance to the outcome. Why he's been embracing the process more than the outcome. How he plays on the edge in the middle. What led Akshay to find more peace within. [36:40] Don't Be Afraid to Get Off Balance 734 Kirk Parsley MD | Sleep As Medicine: How To Sleep Like Royalty + Stop Being Sick Why Akshay doesn't feel like the polar expedition was dangerous. The importance of allowing ourselves to feel grief. 612 Dr. Michael Gervais | Living An Authentic Life: How to STOP Worrying About What People Think of You Why stillness isn't the same as doing nothing. How getting off balance helps us awaken. [43:10] The End of The Polar Expedition Henry Worsley Why Akshay's diverticulitis was caused by extreme stress. How his body started falling apart in the last 10 days of the polar crossing. Why Antarctica is a mirror to the human soul. How Akshay doesn't struggle with solitude anymore, even though it used to be a trigger for drinking. [47:25] Does Distance Improve Relationships? How Akshay channeled the spirit of Viktor Frankl. Man's Search for Meaning by Viktor Frankl Why having a conversation with Viktor Frankl helped Akshay understand suffering. 538 John Wineland | A New Masculine Paradigm: Leading With Love, Living Your Truth + Healing The World How distance showed Akshay how supportive his wife is. Why separation makes us feel more connected. [54:15] Accept The Isness Why we're stabbed with two darts of suffering, according to Buddha. How bringing conscious awareness to our self-dialogue can help us change it. Why all unnecessary suffering is the resistance to accepting the isness. How embracing the edge of you makes life more joyful. [59:00] Feel It All Why we need to respect the mystery of God. How Akshay saw value in the delusion he was experiencing during the expedition. Why we shouldn't rob our children of their lessons. How Indian parents tend to over-spoil their kids. Why having our kids experience the full range of emotions builds their resilience. The only way out of the suffering is through it. [01:06:30] The Power of Language How soft talk disempowers us. What led Akshay to become more conscious of his language. How our words shape our reality. When we give our pain voice, we give it more power. How all words are conceptual thoughts. [01:11:20] The Reality of Polar Crossing Why Akshay's now on a mission to share his storm with others. What makes him want to go back to Antarctica. Why his goal was to spend 115 days on the polar mission. What he was eating while he was crossing Antarctica. [01:16:10] Turn Your Pain to Your Purpose Why we often want to skip and bypass grief. How anxiety is demonized. Why Akshay doesn't like to sound like a war hero. The importance of turning our pain to purpose. [01:19:45] Suffer Well How we project our unprocessed emotions. Why even therapists project their wounds onto their patients. How happiness is a side effect of pursuing a meaning. Why the people that are constantly struggling are living in the past. How we can learn to suffer well. Uncommon by Mark Divine How silence opens up a space for our inner dialogue. [01:27:00] Stop The Noise Why many bootcamps miss the element of stillness and silence. How stillness is very uncomfortable at first. Why pausing is the key to training our awareness. [01:31:25] Is Parenting A Spiritual Task? Why Akshay's now focusing on his financial wellness. What makes him feel that raising children is terrifying. Why being a parent is a spiritual experience. How Josh knows children choose us as parents. Why children bring us wisdom. How being a father makes men into leaders. [01:38:10] Find Beauty in Suffering How judgment comes from resentment or jealousy. Fearvana Instagram Why fear and nirvana are not opposite but complementary. Flow by Mihaly Csikszentmihalyi How finding beauty in suffering makes life more joyful. [01:43:15] Fear of Other People's Opinion Why Akshay doesn't feel directly affected by Indian culture. How he feared what people would think if he didn't make it through the expedition. Why other people's lens of reality doesn't change who we are. How Akshay only took a day off from walking Antarctica on day 50. [01:47:30] Your Beliefs Hold You Hostage Why Josh wasn't able to start the podcast for 4 years because of his childhood conditioning. Inside Out (2015) Why all paths are a crossroad. We don't rise to the level of the desires that we want, we fall to the level of the struggle that we're willing to endure. How all the suffering Akshay went through was worth it. Why belief is built on the battlefield. We are not defined by our thoughts. How confidence is a result of an action, it's not the fuel for action. [01:56:25] Connection with God Why Akshay didn't have a relationship with God when he was struggling with suicidal thoughts. When Bad Things Happen to Good People by Harold Kushner How he taps into gratitude and the essence of the human spirit. Hacksaw Ridge (2016) Why Akshay wants to help other people cross their own version of Antarctica. The One You Feed Podcast Leave Wellness + Wisdom a Review on Apple Podcasts  

Wellness + Wisdom: Liberated Life Series | Episode 741 Wellness + Wisdom Podcast Host, Josh Trent, and the Liberated Life Series Co-Host, Mar, reveal the secrets to accountability and boundary enforcement without shame or anger, drawing on nonviolent communication and the “rule of three”, and how emotional regulation and clear communication can guide you to practice boundaries in a way that fosters deeper connection and self-trust, no matter how challenging your relationships might be. Join The Liberated Life Tribe We ALL have problems. Stop hiding. Start living life liberated. Learn how to set yourself free from self-sabotage, limiting beliefs, thoughts + behaviors so you will have lifelong confidence + clarity of purpose through a thriving community + practical tools, guiding you to play a new reality game. Discover lifelong confidence, clarity, and a true sense of purpose with practical tools and a supportive community. Learn to rewrite your reality + master a new “reality game.” Unlock your highest potential in your physical, mental, emotional, spiritual + financial SELF beyond your wildest dreams through accessing the power of surrender to trust life + create new results. Join the Tribe Listen To Episode 741 As Josh Trent Uncovers: [00:00] Introduction to Accountability + Boundaries The essence of accountability. Boundaries are essential for self-love and healthy relationships. How much responsibility do we have to hold others accountable? Fear often prevents people from enforcing boundaries; fear is reframed as 'false evidence appearing real.' [03:45] Setting + Practicing Boundaries Boundaries are first set, then practiced; self-regulation and self-accountability are key. Letting go of the fear of 'burning bridges' is crucial when enforcing boundaries. Boundaries should be communicated clearly, especially in family and intimate relationships, where they are often hardest to enforce. Practicing boundaries with strangers or in low-stakes situations helps build skill and courage. [07:20] Learning from Broken Boundaries + Pain Pain from broken boundaries teaches self-love and integration. Rigid boundaries may block love and growth; flexibility and self-trust are needed. Repeated lessons occur until boundaries are internalized and enforced naturally without fear or anger. [09:45] Nonviolent Communication + Boundary Enforcement Boundaries can be enforced without shame or anger, using curiosity and dialogue. Public and private boundary enforcement share the same principles: identify the breach, ask questions, and seek shared outcomes. Role-play example demonstrates the 'rule of three' for boundary communication: verbalize the breach, bring curiosity, and co-create a result. Adding emotional context (how it makes you feel) enhances understanding and connection. [19:35] Emotional Regulation + Honesty Breath and presence are essential for emotional regulation during boundary conversations. Triggers are opportunities for growth; honesty about feelings creates clarity and speed in resolving issues. Slowing down communication and being honest about triggers or fears leads to better outcomes. Honesty is the foundation for clarity, which in turn enables faster resolution and connection. [24:40] Attachment Styles + the Path to Peace Speed in resolving conflict is a universal human desire, but true speed comes from honesty and clarity, not rushing. Attachment styles (anxious and avoidant) influence how people approach boundaries and connection. Sitting in honesty and clarity helps both attachment styles achieve harmony and connection quickly. Awareness is the starting point for all personal growth and boundary work; the series aims to nourish all aspects of self (mental, physical, emotional, spiritual, financial). Leave Wellness + Wisdom a Review on Apple Podcasts

Wellness + Wisdom | Episode 738 What if the stories you're clinging to are preventing you from becoming your truest self? And are they even your stories to begin with? Leadership Coach John Wang joins Josh Trent on the Wellness + Wisdom Podcast, episode 738, to share how cultural pressure, generational wounds, and the fear of “not being enough” shape our identity from a young age, why challenging these scripts can help you rewrite your life, and how to close the gap between who you think you should be and who you really are. "The language that your parents speak to you becomes the language that you speak to yourself for the rest of your life. And if your parents didn't know how to speak the language of love, the language of nurture, the language of understanding, then it's likely that you didn't learn that language either." - John Wang

Story at-a-glance Research shows mangoes significantly improve insulin sensitivity in people with chronic low-grade inflammation by activating genes that enhance the body's natural antioxidant defenses A 12-week study found that consuming freeze-dried mango pulp daily led to reduced blood glucose levels in obese adults At the cellular level, mango polyphenols activate the AMPK signaling pathway — the cell's master metabolic switch — promoting fat breakdown while suppressing the formation of new fat cells Regular mango consumption demonstrates measurable benefits for insulin function, with study participants showing lower fasting insulin concentrations and improved HOMA-IR scores compared to control groups Mango polyphenols help reduce inflammation by decreasing proinflammatory cytokines, suggesting benefits for preventing obesity-related diseases

Welcome to the metabolism masterclass!Dr. Ben Bikman (Ph.D Professor BYU), a powerhouse in metabolism science, joins Dave to expose the truth about insulin resistance—the silent epidemic fueling obesity, chronic disease, and low energy. Forget the outdated calorie-counting nonsense (it doesn't work)—Dr. Bikman reveals how your hormones, not just your diet, control your metabolism and what you can do to reset it fast. From debunking diet myths to uncovering why some people can eat 400 grams of carbs and never gain fat (hint: it's not what you think), this episode unpacks the real science of fat storage, energy, and optimal health. Get ready for mind-blowing insights, metabolic hacks, and a new way to think about food, fasting, and longevity. What You'll Learn: • The #1 driver of insulin resistance—and why most doctors miss it • Why eating more fat (yes, really) could be the key to reversing metabolic dysfunction • How fasting, cold therapy, and red light impact your metabolism • The truth about carbs, seed oils, and why some people can't gain fat • How to tell if insulin resistance is wrecking your energy & health Resources: • Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Benjamin's new book How Not To Get Sick : https://a.co/d/aADlMWv • Benjamin's YouTube Page – https://www.youtube.com/@benbikman • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey's Website: https://daveasprey.com • Dave Asprey's Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com SPONSORS: -Lumiram | Go to http://healthlighting.com/dave to save 10% on your order. -Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. Timestamps: 00:00 Trailer 00:52 Introduction to Dr. Benjamin Bikman 02:20 The Battle Against Conventional Dietetics 04:12 Understanding Insulin Resistance 06:29 The Two Paths to Insulin Resistance 10:19 Fasting and Metabolic Health 14:11 Insulin and Cognitive Enhancement 18:16 Identifying Insulin Resistance 30:12 The Role of Insulin in Fat Storage 42:04 Understanding Glucose and Insulin Dynamics 42:26 The Role of Exercise in Glucose Regulation 42:54 AMPK and Muscle Contraction 45:21 Calories In, Calories Out Debate 46:15 The Myth of Calorie Counting 50:13 Ketosis and Metabolic Rate 51:14 Intermittent Fasting and Muscle Preservation 55:21 Insulin Resistance and Ketogenic Diets 01:02:04 Circadian Rhythm and Insulin Sensitivity 01:08:08 Environmental Toxins and Insulin Resistance 01:13:03 The Impact of Seed Oils on Insulin Resistance 01:19:22 Final Thoughts and Resources See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.