Podcasts about ampk

What if true freedom demands separation from old beliefs? Josh Trent welcomes Preston Smiles, Abundance and Money Coach, to the Wellness + Wisdom Podcast, episode 752, to reveal how our need for external validation hijacks our true potential and abundance, what it really takes to break free from generational wounds, and why the commodification of spirituality will only be undone by uncompromising honesty and a relaxed nervous system. In This Episode, Preston Smiles Uncovers: [01:10] Why Most Self-Development Is “Blind Leading the Blind” Why healing doesn't have a hierarchy. How all fathers hold the hard things inside. Why nobody is better than anybody. What makes us chase the feeling of significance. How we're taught to seek validation outside of ourselves. Why most self-development is blind leading the blind. Resources: Preston Smiles 092 Now or Never: Alexi Panos & Preston Smiles [09:35] Being Honest with Your Children Why honesty is a gift to our children. How Preston's children witnessed a conflict between him and his wife. Why he apologized to his wife in front of his children after they had a fight. How being a demonstration is what lands the most for people. [13:00] How to Repair After Conflict Why God only hears 'yes.' How the body stores everything we've ever been through. What creates neurotags in the body. How not addressing our neurotags makes us harden. Why most of us didn't learn how to clear guilt, shame, and trauma from our body. The importance of having proactive practices to prevent disease. [18:30] The Role of A Father Why most of Preston's childhood friends didn't fulfil their potential because their fathers weren't present. How his father encouraged him to be a leader. Why most people don't have a father that's loving and present. Resources: Dead Poets Society (1989) [23:35] How to Be Free Why Preston quit being a reverend twice in his life. Science of Mind by Ernest Holmes The importance of questioning our answers. What is behind our belief that money is hard to come by. How questioning our path can set us free from generational wounds and beliefs. Resources: Spiritual Millionaire by Preston Smiles [29:00] Why Elevation Requires Separation How repair provides a space to ask each other questions. How we become like the people we spend time with. Why his wife was the first person Preston ever made love with. What led him to go deep into esoterics and conspiracies. [35:20] You Can Heal Yourself The difference between healthy and toxic fear. How Preston developed a skin disease and fell into shame when he was a teenager. Why he needed to process the abuse he went through as a child. How acknowledgment helped him heal. Why he did 31 ayahuasca ceremonies in a year. How people began to be part of Preston's healing. Resources: You Can Heal Your Life by Louise Hay [40:25] The Next Level of Law of Attraction The missing link to the law of attraction. Why the work is constant remembering of what is actually here. How learning to love what is opens up the door for us. Why we need to choose but not want. What we can't stop thinking about, it's our calling. How Preston connects with God. Why hearing God's voice when he was 15 saved his life. How he met his wife through listening and trusting God. Resources: The Secret by Rhonda Byrne 674 Daniele Kathryn Hage | Gender Equality vs. Gender Equity: How to Have a Lasting + Loving Relationship For Life [49:20] Healing Porn Addiction What made Josh realize that porn addiction was his own choice. How Preston approaches his children's sexuality. Why pornography is a tool of control. How he finally chose to see sex as a sacred act. [56:50] Is Demonic Energy Ever Good? How even demonic energy can serve us to awaken. Why the demonic energy is not the urge but the marketing machine that sold us the urge. How the bad things in our lives are our teachers on a soul level. [01:01:35] The Wounded Ego Why it's not our fault when we fall into addiction. How social media glorifies toughness. Why Preston's team didn't stop working when he decided to let them go. How he used to feel better than everyone. [01:08:05] How Much Money Do You Really Need to Be Happy? How Josh has worked through his relationship and money wounds to get where he is now. Why there is a point where money doesn't matter anymore. How Preston learned to appreciate his tiny apartment back in the day. Why get more if we can't love what we have now. How some rich people identify with the status of money and get controlled by it. Why Preston doesn't keep the things that make him attach to his ego. [01:14:45] Cheaters Don't Last How people have used Preston to climb the career ladder. Why his friend stole his workshop. How people who cheat other people don't last long in the game. Resources: Tai Lopez Grant Cardone [01:22:05] Spiritual Commodification Why the antidote to the commodification of spirituality is honesty. The importance of crediting those we've learned from. Why scarcity tells us there's not enough for everyone to share. How abundance comes from a relaxed nervous system. Why most people have a very small window of tolerance. Leave Wellness + Wisdom a Review on Apple Podcasts

️ Zona 2 y mitocondrias: LA VERDAD INCÓMODA que NO TE CUENTAN en los podcasts ¿De verdad entrenar en Zona 2 “crea mitocondrias”? ¿O estamos simplificando en exceso lo que pasa en tu cuerpo? En este episodio rompemos mitos y explicamos lo que realmente dice la fisiología del ejercicio: ✔️ Qué es la Zona 2 (y qué NO es) ✔️ Por qué hablar de ella sin entender el umbral aeróbico, VO₂ y lactato es un error ✔️ Qué papel juegan PGC-1α, AMPK, CaMK, mTOR y ROS ✔️ Cómo influyen la intensidad y el volumen en tus adaptaciones mitocondriales ✔️ Y por qué muchos divulgadores huyen del debate científico Si te interesa entrenar mejor, entender tu cuerpo y dejar de seguir modas mal explicadas, este vídeo es para ti. Ciencia real. Sin humo. Sin dogmas. Déjame en comentarios: ¿Qué otros mitos sobre el entrenamiento te gustaría que desmontáramos?

In this episode, we delve into the fascinating world of C15, a newly recognized essential fatty acid, and its implications for longevity and health. Our guest, a leading expert in the field, Dr. Stephanie Venn-Watson shares her insights into the discovery and significance of C15, drawing connections between human health and findings from dolphin studies. Website - https://fatty15.com/JILLCARNAHAN  Key Discussions: ① The Discovery of C15:

Wellness + Wisdom: Liberated Life Series | Episode 749 Join Josh Trent, host of the Wellness + Wisdom Podcast, and Mar, co-host of the Liberated Life Series, as they shine a light on the shadow side of awareness, revealing why simply knowing what needs to change rarely ignites transformation. In this episode, they journey into the hidden inner-child wounds that shape our beliefs about worthiness and love, and share actionable insights for moving beyond awareness into genuine growth. We ALL have problems. Stop hiding. Start living life liberated. Learn how to set yourself free from self-sabotage, limiting beliefs, thoughts, and behaviors so you will have lifelong confidence and clarity of purpose through a thriving community and practical tools, guiding you to play a new reality game. Join Josh and others in the Liberated Life Tribe to: Discover lifelong confidence, clarity, and a true sense of purpose with practical tools and a supportive community. Learn to rewrite your reality + master a new “reality game.” Unlock your highest potential in your physical, mental, emotional, spiritual + financial SELF beyond your wildest dreams through accessing the power of surrender to trust life + create new results. Join the Tribe Today (It's FREE) Listen To Episode 749 As Josh Trent Uncovers: [00:00] Understanding Awareness vs. Action The disconnect between knowing and doing Why awareness alone isn't enough to create change Mar shares her personal struggle with social media addiction Why we struggle to implement the practices that we know would help us How biological trust must align with conscious knowledge [04:00] Parts Work Exercise (IFS) Josh guides Mar through connecting with her inner child part named 'Maky' (age 12-13) Maky reveals she believes she must 'prove herself to be worthy of love' The inner child expresses discomfort with receiving love, as it feels unnatural Josh helps Mar establish a gentle connection with this part of herself Maky shares that all she ever wanted was love, but doesn't know how to trust [11:55] Healing Through Connection Maky agrees to 'come along' with adult Mar on her life journey Mar acknowledges the paradox of wanting love while being afraid to receive it Mar understands that her parents weren't bad people, but struggled to express love in ways she needed Josh notes how this inner child connection is the missing piece between awareness and action The exercise reveals how external behaviors (like social media scrolling) are clues to deeper emotions [24:25] Integration + Transformation Why awareness isn't about 'fixing' but about loving ourselves into trusting life again How emotional patterns get passed through epigenetics Why awareness is just a guidepost leading to deeper understanding The ultimate goal is liberation through genuine peace and trustworthy power Leave Wellness + Wisdom a Review on Apple Podcasts

Welcome back to the Longevity Podcast! I'm so excited for today's episode, where I sit down with Chris Rhodes—nutritional biochemist, fasting researcher, and CEO of Mimio Health—to dive deep into one of the most fascinating emerging topics in longevity science: fasting mimetics. If you've ever wanted to get the regenerative, anti-inflammatory, and health-boosting effects of fasting, but struggled to actually fast for 36 hours or more (trust me, I get it!), this conversation is for you. Listeners of this podcast can visit mimiohealth.com/nat and use code NAT FOR 20% off your first single purchase or subscription order.   What we discuss: Meet Chris Rhodes and his biomimetic research journey ... 00:05:18 Unlocking fasting benefits without prolonged fasting ... 00:09:10 Supplements vs. pharmaceuticals for longevity ... 00:10:53 Fasting protocols, timing, and metabolic switching ... 00:15:23 Risks of fasting, evolutionary adaptation, and muscle/bone loss ... 00:18:34 Ketones, brain energy, and cognitive adaptation ... 00:22:48 How fasting activates longevity and repair pathways ... 00:26:23 Key cellular pathways: AMPK, mTOR, NAD, sirtuins ... 00:28:04 Mimio research: discovering and testing fasting metabolites ... 00:33:35 The four main fasting mimetic molecules explained ... 00:42:04 Practical benefits: who should use fasting mimetics & safety ... 00:59:00 Mimio in use: hunger control, GLP-1 support, and older adults ... 01:03:37   Our Amazing Sponsors: Qualia NAD+ - This vital molecule powers cellular energy, supports DNA health, aids detox, and helps keep your body remain youthful. Visit qualialife.com/nathalie to try Qualia NAD+, backed by a 100-day money-back guarantee, and use promo code NATHALIE for 15% off! OraltidePro - A unique mouthwash that: Promotes growth of shrinking gums, Speeds healing of mouth & tongue, Prevents oral infections (such as gingivitis), Helps with enamel remineralization, Reduces bacteria growth and etching and Fills slots in damaged enamel. Check out OraltidePro at profound-health.com and use code NAT15 for 15% off your first order. Bio-Shield by Young Goose - A broad-spectrum serum that protects against UVA/UVB, infrared, AND high-energy visible (HEV) light. Visit YoungGoose.com—use code NAT10 to get started, or 5NAT if you're an existing customer.     More from Nat:  YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

Wellness + Wisdom: Liberated Life Series | Episode 747 Wellness + Wisdom Podcast Host, Josh Trent, shares the top 10 things that changed his life and led him on a deeper journey of self-discovery and transformation. He explores the profound impact of breathwork and conscious relationships, revealing how these practices can unlock emotional freedom and inner peace. We ALL have problems. Stop hiding. Start living life liberated. Learn how to set yourself free from self-sabotage, limiting beliefs, thoughts, and behaviors so you will have lifelong confidence and clarity of purpose through a thriving community and practical tools, guiding you to play a new reality game. Join Josh and others in the Liberated Life Tribe to: Discover lifelong confidence, clarity, and a true sense of purpose with practical tools and a supportive community. Learn to rewrite your reality + master a new “reality game.” Unlock your highest potential in your physical, mental, emotional, spiritual + financial SELF beyond your wildest dreams through accessing the power of surrender to trust life + create new results. Join the Tribe Today (It's FREE) Listen To Episode 747 As Josh Trent Uncovers: [01:30] Breathwork as Foundational Practice Why breath is the most transformative tool that helped Josh with his personal struggles with addiction. Breathwork is both a voluntary and involuntary lever for the autonomic nervous system, impacting vagal tone and overall well-being. The journey of studying breathwork to launch BREATHE: Breath + Wellness Program in 2020. [02:45] Parts Work Why parts work is crucial for understanding and integrating inner child and protector dynamics. How the method is integrated into the Emotional Epigenetics L.I.F.E. Method program, focusing on nervous system trust and self-acceptance. [03:55] Conscious Relationship Why conscious relationships are powerful catalysts for personal growth, ego dissolution, and healing generational wounds. How the soulmate's prayer helped Josh find his partner. The importance of soul unions in triggering and healing deep-seated issues. [05:10] Letting Go of Pornography How pornography is normalized by our society. Addiction is reframed as a symptom of disconnection from self and others, with freedom found in truth and self-honesty. The importance of identifying and addressing our addictions. [08:05] Influence of David Hawkins + Alan Watts The role of David Hawkins' frequency scale. How the teachings help bridge the gap between mind and heart, and shape the Emotional Epigenetics methodology. The importance of feeling and integrating emotions for personal growth. [09:30] Mindful Language + NLP Why words are spells. How NLP (Neuro-Linguistic Programming) serves as a tool for self-programming and transformation. The importance of replacing negative self-talk with empowering language to transform our nervous system and mindset. [12:30] Brotherhood + Men's Work The value of men's groups and brotherhood is discussed, highlighting the importance of being witnessed and supported by other men. Why men's groups are a space for sharing, questioning, and impact without coaching, fostering authenticity and emotional release. [14:00] Wellness Care Routine Why wellness routines (stretching, reading, sauna, cold plunge) are essential for anchoring peace and supporting epigenetic health. The importance of committing to one wellness ritual and building consistency before adding more. [16:25] Plant Medicine (Caution + Wisdom) Why plant medicine is transformative but potentially risky if approached with the wrong intention or in excess. How plant medicine allowed Josh to face his pornography addiction. The importance of respect, intention, and integration in using plant medicine. [19:05] Fatherhood Fatherhood (or motherhood) is the greatest teacher, expanding capacity for patience, forgiveness, and presence. How imperfect but present parenting with inner child work can deepen the connection to our children. Leave Wellness + Wisdom a Review on Apple Podcasts

Can we really reverse biological age?  In this groundbreaking episode, I sit down with Greg Macpherson, biotechnologist, pharmacist, and founder of SRW Laboratories, to explore the cutting-edge science behind reversing biological ageing — backed by real human clinical trial data. We discuss SRW's latest clinical study, which demonstrated measurable reductions in biological age markers through targeted supplementation. Greg unpacks how biological age is assessed using epigenetic markers like DNA methylation, and how SRW's formulations are designed to influence key aging pathways including: sirtuins, NAD+ production, AMPK, and mTOR modulation. What you'll learn from the episode:  What biological age really means  How SRW's trial measured age reversal using TruDiagnostic epigenetic clocks  Key molecules and compounds driving the effect  The importance of cellular senescence, mitochondrial function, and genomic stability  What's next in the field of longevity biotechnology Whether you're a health professional, biohacker, or longevity enthusiast, this episode is packed with science-forward insights and actionable takeaways. Shop SRW supplements here: SRW Supplement Range  Follow Greg Macpherson: Linkedin/Greg Nacpherson SRW  Explore epigenetic testing: Trudiagnostic - TruAge COMPLETE Greg Macpherson: Throughout my career, I have been driven by a desire to help people achieve their potential by overcoming health challenges. As a biotechnologist, futurist, author, and pharmacologist, I have pursued this goal by founding one of the first online pharmacies in New Zealand and creating the country's first Government licensed robotic dispensing facility. My current focus is on understanding cellular aging and developing new formulations to support healthy aging and improve human health. For the past 10 years, I have been researching cellular aging and consulting with global experts in the field. All of this research and experience has led me to establish SRW, an organization that aims to translate scientific advancements into practical solutions for everyday people to live longer, healthier lives.  

Wellness + Wisdom | Episode 746 Are you ready to reconfigure your past and reimagine humanity's future through the power of outrageous love? Visionary Philosopher Marc Gafni joins Josh Trent on the Wellness + Wisdom Podcast, episode 746, to guide you from mythic narratives of soul mates to the co-creative vision of whole mates: evolutionary partners in service of the cosmos. Learn how the gift of suffering becomes the pathway to transcendence, why raising children is a spiritual act of embodiment, and how solving humanity's value crisis can spark a galactic awakening. "Soulmate relationships don't work. They're insufficient. If a couple is not looking at a shared horizon and they are only looking deeply in each other's eyes, it will not work. Whole mates are not just looking deeply in each other's eyes. They're first looking at a shared horizon, a shared mission. They're looking at the whole. They're in a relationship to the whole. And then from there, they turn back and look at each other." - Marc Gafni In This Episode, Marc Gafni Uncovers: [01:20] Outrageous Love Marc Gafni Why 'I love you' is our sacred creed. How facing death puts us in our visceral truth. Why we've lost connection to the meaning of 'I love you.' The difference between ordinary love and outrageous love. How love allows us to give our unique gifts. When we're in love, we feel welcome in the cosmos. Why reality is not a fact but an outrageous love story. How reality is generated. [09:50] What Is Evolution? Whole Mate by Marc Gafni The three levels of knowing. How we get lost in the complexity, which blocks us from seeing the depth. Every place we've been, we needed to be. Why every detour is part of the destination. How reality has mathematical, musical, molecular, metabolic, moral, and mystical values. Why reality is movement towards transformation. Evolution is love in action in response to need. How becoming what reality intended us to be, divinity experiences self-recognition through us. If we don't have the experience that we matter, our mind, heart, and body break down. [20:20] The Three Faces of God Why the God we don't believe in doesn't exist. The importance of the word 'God.' Why outrageous love is not a response to another person but the love that moves through us. The three faces of God: first, second, and third person. Neil deGrasse Tyson How religions show the faces of God. [29:50] New World Why we're in a time between worlds. How 40% of AI researchers believe that AI could destroy all humanity. 692 Paul Chek | Spirit Gym: How To Find The Truth of Your Soul + Live Your Dream How we can create a new story of values for the world. [35:45] Divine Loneliness Why God is lonely. How we need separation to create intimacy. What it means to be lonely. How Marc's son made him see the human singularity. The importance of knowing our soul print. How we cover up our emptiness by getting our attention hijacked. Why we need to sit in loneliness in order to fill up with our soul print. The divine is being, spaciousness, and becoming. Why evolution is a love story of the universe. How wholeness comes from brokenness. [47:25] Pseudo-Eros + Shame Why pornography is pseudo-Eros. How pornography is explicit sexuality taken out of the context of a story. Why our relationship to essence is always sensual. How our shame tells a story that we're wrong. Why a great saint makes new mistakes. The meaning of the word 'hallelujah.' [56:10] From Soul Mate to Whole Mate Why soulmate relationships don't work. Evolution of Love from Quarks to Culture by Marc Gafni, Zak Stein + Elena Levin Why reality is evolution, relationships, and the evolution of relationships. How crisis drives evolution, and the movement is an evolution of relationships. The evolution from role mate to soul mate to whole mate. The Boy Crisis by Warren Farrell + John Gray How each one of us has a role within a relationship in order to survive and thrive. Love Story (1970) [01:11:50] How Movies Tell The Story of Reality How the Matrix movie displays a whole mate relationship. The 5 Love Languages by Gary Chapman Why Mars and Venus Collide by John Gray Getting The Love You Want by Harville Hendrix How love replaced our values. Why sexuality is not personal but universal. The importance of having a shared vision as a couple. Social Physics by Alex Pentland Why most children don't believe in love anymore. Sapiens by Harari Yuval Noah [01:30:35] Raising Children As Whole Mates 744 Debra Silverman | Your Pain Has a Pattern… and Astrology Reveals It All (This Isn't Random) What embodiment feels like. Why raising children is more than a role mate part. How we can serve the larger whole. Phenomenology of Eros by Jonna Bornemark + Marcia Sa Cavalcante Schuback The reason why most relationships don't work. Why monogamy is a practice. Why relationships are the basic structure of reality. How most couples therapists don't address the issue of not having a shared vision. [01:42:15] Our Deepest Desires Our Divine Desires Why God is the intimate infinite. How creating a new intimacy creates a new God. Why spirituality and religion must come together. How our desire to become more intimate comes from God. [01:48:55] The Purpose of Evolution Why the purpose of evolution is the evolution of love. How the evolution of love is the evolution of God. Why whole mates are evolutionary partners. An atom is a new value of intimacy. How we move from matter to life. Why power gives us pleasure and dignity. How we can impact the whole world. Why we're never powerless. Enlightenment means to know the nature of reality. [01:58:55] Reconfigure Your Past What creates a capacity to transform. How we can get beneath time. Why we can undo our mistakes. How transforming our will transforms our deeds. [02:07:10] New Humanity + Existential Risks How we can practice love in the moments of pain. Why the universe feels love. How outrageous lovers commit outrageous acts of love. Why war is not inevitable. We can create a new human and a new humanity. How the cosmos is moving towards more goodness. What existential risks we're facing as humanity. Reimagining Humanity's Identity: Responding to the Second Shock of Existence by Marc Gafni + Zachary Stein Why evolution doesn't stop. [02:17:05] Solving Value How the process of getting deeper is our joy. First Principles and First Values by David J. Temple Why there are different qualities of love. How the new age community doesn't do the deep work. Why we need to solve the value to create a change in the world. [02:25:30] What Is Value? How the source code is corrupted because the story of value has gotten lost. Why we need to go to the source code to clarify our values. What makes us question ourselves. How reality desires to evolve the source code. Why we're on the edge of a galactic moment. Avatar (2009) Leave Wellness + Wisdom a Review on Apple Podcasts

Explore the science behind the "Sugar Diet," a low-protein, high-carbohydrate or high-fat dietary regimen. We'll discuss how this approach influences metabolic pathways, its potential benefits for fat loss, and the importance of nutrient quality in achieving optimal health outcomes. All things considered, do we recommend anyone utilize this strategy? Tune in to find out! APPLY FOR COACHING: https://www.lvltncoaching.com/1-1-coaching SDE Method app: https://www.lvltncoaching.com/sde-method-app Macros Guide https://www.lvltncoaching.com/free-resources/calculate-your-macros Join the Facebook Community: https://www.facebook.com/groups/lvltncoaching FREE TOOLS to start your health and fitness journey: https://www.lvltncoaching.com/resources/freebies Alessandra's Instagram: http://instagram.com/alessandrascutnik Joelle's Instagram: https://www.instagram.com/joellesamantha?igsh=ZnVhZjFjczN0OTdn Josh's Instagram: http://instagram.com/joshscutnik ‍ Timestamps: 00:00 Introduction and Birthday Celebrations 02:57 Understanding the Sugar Diet 05:58 The Science Behind Low Protein Diets 09:56 Critique of the Sugar Diet 12:43 Metabolic Health and Individual Responses 15:51 Long-term Implications of the Sugar Diet 18:50 Conclusion and Final Thoughts 23:38 The Impact of Diet on Health 25:38 Understanding mTOR and AMPK 26:33 Taurine and Its Role in Diet 27:28 The Efficiency of Low Protein Diets 29:24 The Nuances of Dietary Strategies 30:17 Target Audience for New Diets 31:42 The Risks of Misleading Headlines 33:30 The Importance of Metabolic Health 34:46 Navigating the Health and Fitness Industry 36:34 Exploring Nutrient-Dense Carbohydrate Sources 38:24 Limitations of Low Protein Diets 40:11 Long-Term Effects of High Sugar Diets 42:25 Key Takeaways and Recommendations

I’m joined by Neal Mercado, Chief Science Officer at Melrose, one of Australia’s leading wellness brands and the team behind Melrose Future Lab. Neal leads a thought-provoking conversation on ageing, vitality, and the science behind what really works. We unpack the difference between lifespan and health span—because it’s not just about living longer, but living well. From cellular senescence to musculoskeletal strength, we look at ingredients leading wellness conversations and the future of longevity science. Neal also lifts the lid on supplement quality, why not all extracts are created equal, and explains the concept of bioavailability to actually move the needle. If you’re navigating perimenopause, curious about longevity, embarking on strength training, or trying to make sense of the supplement aisle, this episode will help you cut through the noise and make informed, future-focused choices. In partnership with Melrose Future Lab. Key Takeaways: Health span means more years lived well, not just longer Cellular senescence (aka “zombie cells”) reduces function as we age Berberine can support healthy blood glucose and AMPK activation Quality matters: not all herbal extracts or proteins are created equal Collagen, especially bovine-derived, supports muscle health Strength training is essential for bone density in menopausal women Supplement bioavailability is as important as the ingredients themselves Innovative formulations are changing how we absorb nutrients Menopause research is decades behind other women’s health areas Perimenopausal women benefit from tailored support and active nutrients Intermittent fasting and autophagy support cellular repair Effective supplements are about formulation—not fads Chapter: 00:00 – The Importance of Health Span vs Longevity03:05 – Understanding the Hallmarks of Ageing05:58 – Cellular Mechanisms of Ageing and Longevity09:12 – The Role of Supplements in Ageing Well11:59 – Berberine: A Key Player in Longevity15:02 – Navigating the World of Supplements18:02 – The Future of Health and Wellness26:32 – Musculoskeletal Health and Ageing34:00 – Innovations in Formulation and Bioavailability38:01 – Addressing Menopause and Perimenopause45:23 – The Importance of Formulation Over Ingredients Watch the full episode here: https://youtu.be/i65uno_HZQoSee omnystudio.com/listener for privacy information.

In this episode of the Ageless Future, Regan Archibald dives deep into the world of peptides and muscle-building for longevity. He explores key muscle pathways like mTOR and AMPK, explains the importance of balancing growth and recovery, and highlights powerful peptides including CJC-1295, Ipamorelin, IGF-1 LR3, BPC-157, 5-Amino-1MQ, and SS-31. Regan also shares personal goals, advanced stacking strategies, and insights into how peptides like ACE-031 and MOTS-c help prevent sarcopenia and boost VO2 max. Whether you're optimizing for strength, recovery, or long-term vitality, this episode gives you the tools to strategically enhance muscle health at any age. www.agelessfuture.com

In this solo episode of The Red Light Report, Dr. Mike explores the profound connection between mitochondrial health and oral disease. He reviews three recent studies highlighting how red light therapy, methylene blue, and compounds like urolithin A can support oral tissues, reduce inflammation, and even impact systemic conditions like diabetes and neurodegeneration. From root canal innovations to mitophagy in periodontitis, this episode is full of cutting-edge insights and practical applications for anyone interested in longevity, biohacking, or oral health optimization.Key Topics Covered:Study #1: Methylene Blue + Graphene Oxide for Root Canal Photodynamic Therapy• Combining methylene blue and reduced graphene oxide with red light therapy significantly improves antibacterial and antifungal effects in root canals.• Highlights the synergy between methylene blue and red light.• Dr. Mike shares how his nighttime routine—using BioBlue Calm and a red-light toothbrush—may create a low-level photodynamic therapy effect in the mouth.Study #2: Mitophagy in Periodontal Disease• Mitophagy (mitochondrial autophagy) plays a key role in managing inflammation, bone remodeling, and cell death in gum disease.• Key interventions to enhance oral mitophagy:• Urolithin A (strong Pink1/Parkin pathway activator)• Resveratrol, Melatonin (support mitochondrial quality)• Berberine, Curcumin, Metformin (via AMPK activation)• NR, Quercetin (via SIRT1 + PGC-1α pathway)Study #3: Mitochondrial Dysfunction Links Oral and Systemic Diseases• Periodontitis driven by mitochondrial dysfunction is linked to diseases like diabetes, cardiovascular disease, and neurodegeneration.• Key issues:• Impaired mitochondrial fusion/fission, biogenesis, and mitophagy.• Excessive ROS and mitochondrial DNA leakage fuel inflammation.• Poor mitochondrial function impairs periodontal stem cell regeneration.• Therapeutic approaches:• Antioxidants (CoQ10, resveratrol, melatonin, curcumin, EGCG)• Photodynamic therapy (methylene blue + red light)• Mitochondria-targeted compounds to modulate apoptosis and inflammation.Dr. Mike's Takeaways• Oral mitochondrial health is foundational—not isolated from systemic health.• Red light therapy and methylene blue offer powerful synergistic effects, even in oral applications.• A mitochondria-first approach may provide long-term protection against oral and systemic disease.   If you found the information in today's episode particularly interesting and/or compelling, please share it with a family member, friend, colleague and/or anyone that you think could benefit and be illuminated by this knowledge. Sharing is caring :)As always, light up your health! - Key points: 00:00 – Introduction: Mitochondrial Health & Podcast Focus 00:32 – Announcements: Health Alchemy Bundle & Upcoming Events 06:18 – Study 1: Methylene Blue & Red Light Therapy for Root Canal Treatment 08:42 – Methylene Blue Benefits Recap 13:37 – Study 1 Discussion: Photodynamic Therapy Enhancements 16:57 – Practical Application: Methylene Blue for Oral Health 19:40 – Study 2: Mitophagy in Periodontal Disease 23:46 – Targeted Mechanisms to Enhance Mitophagy 28:42 – Study 3: Mitochondrial Dysfunction in Periodontitis & Systemic Diseases 31:38 – Therapeutic Strategies for Mitochondrial Health 41:44 – Integrative Mitochondrial Therapies 47:02 – Conclusion: Mitochondrial Dysfunction as a Core Issue 50:45 – Closing Thoughts & Upcoming Events - Articles referenced in episode:Synthesis, characterization, and application of methylene blue functionalized reduced graphene oxide for photodynamic therapy in root canal treatmentMitophagy and Its Significance in Periodontal DiseaseMitochondrial Dysfunction in Periodontitis and Associated Systemic Diseases: Implications for Pathomechanisms and Therapeutic Strategies - Get over $6,000 worth of wellness education from top experts for $50! The Health Alchemy BundleThis is an amazing opportunity put together by Carrie Bennett and Sarah Kleiner! This Bundle is collection of 60+ eBooks, courses, and other resources available for $50 at a mind-blowing 99% discount.     This massive collection of resources is rooted in the science + spirituality of healing with nature, which cover topics like: Circadian & quantum biology Mental, emotional, & spiritual health Nutrition, minerals, & supplementation (when necessary) Herbalism & homeopathy Movement, posture, & fitness Hormonal health, pregnancy, & parenting And even specific issue support—from healing autoimmunity to improving sleep, & more This is a limited opportunity that goes through TOMORROW, May 23rd, so act now and don't miss out!   Get The Health Alchemy Bundle by clicking here! - Upcoming BioLight Events:   Biohacking Conference - May 28 - 30 (Austin, TX)   Returning to Nature (Quantum Health Retreat), June 26 - 27 (Franklin, TN) - Introducing the Newest BioBlue Supplement! The most comprehensive, powerful mitochondrial support supplement on the market ...   What is The Fountain of Youth in simple terms? An unparalleled supplement for brain power, energy, and longevity This supplement is like a high-performance tune-up for your brain and body. It combines powerful natural and science-backed ingredients to help you think clearer, feel more energized, and support your long-term health.The BioBundle automatically saves you 15% on both of the supplements you choose.   For the next two weeks, SAVE 20% on your order of BioBlue Fountain of Youth! Simply use code FOY20 Code expires 5/29, midnight PST   Click here to check out BioBlue Fountain of Youth - Dr. Mike's #1 recommendations: Water products: Water & Wellness Grounding products: Earthing.com EMF-mitigating products: Somavedic Blue light-blocking glasses: Ra Optics - Stay up-to-date on social media: Dr. Mike Belkowski: Instagram LinkedIn   BioLight: Website Instagram YouTube Facebook

Wellness + Wisdom | Episode 742 Is your fear of suffering keeping you from discovering the deepest treasures of your soul? Author and extreme adventurer, Akshay Nanavati, joins Josh Trent on the Wellness + Wisdom Podcast, episode 742, to share how embracing suffering during his 60-day solo crossing of Antarctica became the key to transcending limitations and unlocking pure potential, what his journey taught him about the paradox of oneness, and why the only way out of suffering is through it. "When you stop resisting suffering, it frees you from the grasp of suffering. It's not the suffering in and of itself that I seek. Suffering is the means, not the purpose. The purpose is what it gives you access to. It's the transcendence, the awakening, the breaking down of the illusions, the surrender." - Akshay Nanavati In This Episode, Akshay Nanavati Uncovers: [01:10] 60 Days Alone in Antarctica Akshay Nanavati 606 Akshay Nanavati | How To Love Your Fear: The (REAL) Secret To Unlocking Your Pure Potential How the world shows you more about the human soul than any textbook. Why it's a privilege when we can choose our suffering. How he confronted his inner demons while crossing Antarctica. Why Akshay's biggest mental challenge during the expedition was frustration. How the last 10 days felt like he was drunk. Why he ended the expedition after 60 days due to a life-threatening medical issue. [08:45] How to Stay In The Present Moment What brought Akshay into moments of oneness and bliss during the expedition. The three elements of a raw experience. Why he was pushing himself back into the present moment in order to keep going. How the only thing he could control was his next step. [12:40] The Paradox of Oneness How we all seek different forms of peak experiences. Why the illusion in which we experience life changed for Akshay. Fearvana by Akshay Nanavati How the opposites encompass the human experience. Why the mind creates an illusion of good and bad. How Antarctica made Akshay feel very small but also extremely powerful. Why love is an experience of both separation and connection. How resisting or clinging to duality creates suffering. [19:40] The Gift of Suffering The bigger the dragon we battle, the better the treasure on the other side of the battle. Why the human experience is a paradox. How suffering is the means to transcendence. Why pain connects us to God. How Akshay accepts what is instead of resisting suffering. Why comfort is not the enemy. [26:45] Pure Experience Why reality is not "either, or." How labels create divisions and limitations. Why words can open the door for us, but can't provide the same value as experience. How mastery is about bringing ourselves back to the center. [31:40] Stop Attaching to The Outcome How Akshay's Antarctica crossing helped him shed the resistance to the outcome. Why he's been embracing the process more than the outcome. How he plays on the edge in the middle. What led Akshay to find more peace within. [36:40] Don't Be Afraid to Get Off Balance 734 Kirk Parsley MD | Sleep As Medicine: How To Sleep Like Royalty + Stop Being Sick Why Akshay doesn't feel like the polar expedition was dangerous. The importance of allowing ourselves to feel grief. 612 Dr. Michael Gervais | Living An Authentic Life: How to STOP Worrying About What People Think of You Why stillness isn't the same as doing nothing. How getting off balance helps us awaken. [43:10] The End of The Polar Expedition Henry Worsley Why Akshay's diverticulitis was caused by extreme stress. How his body started falling apart in the last 10 days of the polar crossing. Why Antarctica is a mirror to the human soul. How Akshay doesn't struggle with solitude anymore, even though it used to be a trigger for drinking. [47:25] Does Distance Improve Relationships? How Akshay channeled the spirit of Viktor Frankl. Man's Search for Meaning by Viktor Frankl Why having a conversation with Viktor Frankl helped Akshay understand suffering. 538 John Wineland | A New Masculine Paradigm: Leading With Love, Living Your Truth + Healing The World How distance showed Akshay how supportive his wife is. Why separation makes us feel more connected. [54:15] Accept The Isness Why we're stabbed with two darts of suffering, according to Buddha. How bringing conscious awareness to our self-dialogue can help us change it. Why all unnecessary suffering is the resistance to accepting the isness. How embracing the edge of you makes life more joyful. [59:00] Feel It All Why we need to respect the mystery of God. How Akshay saw value in the delusion he was experiencing during the expedition. Why we shouldn't rob our children of their lessons. How Indian parents tend to over-spoil their kids. Why having our kids experience the full range of emotions builds their resilience. The only way out of the suffering is through it. [01:06:30] The Power of Language How soft talk disempowers us. What led Akshay to become more conscious of his language. How our words shape our reality. When we give our pain voice, we give it more power. How all words are conceptual thoughts. [01:11:20] The Reality of Polar Crossing Why Akshay's now on a mission to share his storm with others. What makes him want to go back to Antarctica. Why his goal was to spend 115 days on the polar mission. What he was eating while he was crossing Antarctica. [01:16:10] Turn Your Pain to Your Purpose Why we often want to skip and bypass grief. How anxiety is demonized. Why Akshay doesn't like to sound like a war hero. The importance of turning our pain to purpose. [01:19:45] Suffer Well How we project our unprocessed emotions. Why even therapists project their wounds onto their patients. How happiness is a side effect of pursuing a meaning. Why the people that are constantly struggling are living in the past. How we can learn to suffer well. Uncommon by Mark Divine How silence opens up a space for our inner dialogue. [01:27:00] Stop The Noise Why many bootcamps miss the element of stillness and silence. How stillness is very uncomfortable at first. Why pausing is the key to training our awareness. [01:31:25] Is Parenting A Spiritual Task? Why Akshay's now focusing on his financial wellness. What makes him feel that raising children is terrifying. Why being a parent is a spiritual experience. How Josh knows children choose us as parents. Why children bring us wisdom. How being a father makes men into leaders. [01:38:10] Find Beauty in Suffering How judgment comes from resentment or jealousy. Fearvana Instagram Why fear and nirvana are not opposite but complementary. Flow by Mihaly Csikszentmihalyi How finding beauty in suffering makes life more joyful. [01:43:15] Fear of Other People's Opinion Why Akshay doesn't feel directly affected by Indian culture. How he feared what people would think if he didn't make it through the expedition. Why other people's lens of reality doesn't change who we are. How Akshay only took a day off from walking Antarctica on day 50. [01:47:30] Your Beliefs Hold You Hostage Why Josh wasn't able to start the podcast for 4 years because of his childhood conditioning. Inside Out (2015) Why all paths are a crossroad. We don't rise to the level of the desires that we want, we fall to the level of the struggle that we're willing to endure. How all the suffering Akshay went through was worth it. Why belief is built on the battlefield. We are not defined by our thoughts. How confidence is a result of an action, it's not the fuel for action. [01:56:25] Connection with God Why Akshay didn't have a relationship with God when he was struggling with suicidal thoughts. When Bad Things Happen to Good People by Harold Kushner How he taps into gratitude and the essence of the human spirit. Hacksaw Ridge (2016) Why Akshay wants to help other people cross their own version of Antarctica. The One You Feed Podcast Leave Wellness + Wisdom a Review on Apple Podcasts  

Wellness + Wisdom: Liberated Life Series | Episode 741 Wellness + Wisdom Podcast Host, Josh Trent, and the Liberated Life Series Co-Host, Mar, reveal the secrets to accountability and boundary enforcement without shame or anger, drawing on nonviolent communication and the “rule of three”, and how emotional regulation and clear communication can guide you to practice boundaries in a way that fosters deeper connection and self-trust, no matter how challenging your relationships might be. Join The Liberated Life Tribe We ALL have problems. Stop hiding. Start living life liberated. Learn how to set yourself free from self-sabotage, limiting beliefs, thoughts + behaviors so you will have lifelong confidence + clarity of purpose through a thriving community + practical tools, guiding you to play a new reality game. Discover lifelong confidence, clarity, and a true sense of purpose with practical tools and a supportive community. Learn to rewrite your reality + master a new “reality game.” Unlock your highest potential in your physical, mental, emotional, spiritual + financial SELF beyond your wildest dreams through accessing the power of surrender to trust life + create new results. Join the Tribe Listen To Episode 741 As Josh Trent Uncovers: [00:00] Introduction to Accountability + Boundaries The essence of accountability. Boundaries are essential for self-love and healthy relationships. How much responsibility do we have to hold others accountable? Fear often prevents people from enforcing boundaries; fear is reframed as 'false evidence appearing real.' [03:45] Setting + Practicing Boundaries Boundaries are first set, then practiced; self-regulation and self-accountability are key. Letting go of the fear of 'burning bridges' is crucial when enforcing boundaries. Boundaries should be communicated clearly, especially in family and intimate relationships, where they are often hardest to enforce. Practicing boundaries with strangers or in low-stakes situations helps build skill and courage. [07:20] Learning from Broken Boundaries + Pain Pain from broken boundaries teaches self-love and integration. Rigid boundaries may block love and growth; flexibility and self-trust are needed. Repeated lessons occur until boundaries are internalized and enforced naturally without fear or anger. [09:45] Nonviolent Communication + Boundary Enforcement Boundaries can be enforced without shame or anger, using curiosity and dialogue. Public and private boundary enforcement share the same principles: identify the breach, ask questions, and seek shared outcomes. Role-play example demonstrates the 'rule of three' for boundary communication: verbalize the breach, bring curiosity, and co-create a result. Adding emotional context (how it makes you feel) enhances understanding and connection. [19:35] Emotional Regulation + Honesty Breath and presence are essential for emotional regulation during boundary conversations. Triggers are opportunities for growth; honesty about feelings creates clarity and speed in resolving issues. Slowing down communication and being honest about triggers or fears leads to better outcomes. Honesty is the foundation for clarity, which in turn enables faster resolution and connection. [24:40] Attachment Styles + the Path to Peace Speed in resolving conflict is a universal human desire, but true speed comes from honesty and clarity, not rushing. Attachment styles (anxious and avoidant) influence how people approach boundaries and connection. Sitting in honesty and clarity helps both attachment styles achieve harmony and connection quickly. Awareness is the starting point for all personal growth and boundary work; the series aims to nourish all aspects of self (mental, physical, emotional, spiritual, financial). Leave Wellness + Wisdom a Review on Apple Podcasts

In Episode 77 of the Athletes Compass Podcast, hosts Paul Warloski, Marjaana Rakai, and Dr. Paul Laursen dive into listener questions about VO2 max training, with a focus on the nuances of interval sessions like 30-30s, 40-20s, and five-minute efforts. They explore the importance of pacing, individual adaptation, terrain selection, and recovery while emphasizing context-specific approaches. The team also discusses the role of AMPK signaling, managing training load, and the mind-body connection that can influence performance. The key takeaway? There's no one-size-fits-all solution, but thoughtful adjustments can optimize results while safeguarding long-term consistency and health.Key TakeawaysPacing is essential: Go hard but leave a rep or two in the tank; pacing ensures quality across intervals.Context matters: Terrain, event specificity, and athlete type should guide interval choice (e.g., 30-30s vs. 40-20s vs. 5x5).Open workouts > erg mode: Open formats allow day-to-day variability and better adaptation.Mind-body connection is key: Visual feedback “blinding” can reveal untapped potential and overcome self-doubt.AMPK signaling explained: Both VO2 max and long aerobic sessions stimulate mitochondrial growth; mode impacts neuromuscular load.Recovery is non-negotiable: HRV, sleep, and overall fatigue should inform when to push or ease off.Perfect is the enemy of great: Slight deviations in power or terrain are acceptable if the training goal is still met.Specificity as race day nears: Adapt sessions based on course demands closer to competition.Paul Warloski - Endurance, Strength Training, YogaMarjaana Rakai - Tired Mom Runs - Where fitness meets motherhood.

Wellness + Wisdom | Episode 738 What if the stories you're clinging to are preventing you from becoming your truest self? And are they even your stories to begin with? Leadership Coach John Wang joins Josh Trent on the Wellness + Wisdom Podcast, episode 738, to share how cultural pressure, generational wounds, and the fear of “not being enough” shape our identity from a young age, why challenging these scripts can help you rewrite your life, and how to close the gap between who you think you should be and who you really are. "The language that your parents speak to you becomes the language that you speak to yourself for the rest of your life. And if your parents didn't know how to speak the language of love, the language of nurture, the language of understanding, then it's likely that you didn't learn that language either." - John Wang

In this energizing episode, Regan Archibald dives deep into the remarkable benefits of MOTS-c, a mitochondrial-derived peptide that's transforming how we think about energy, metabolism, and aging. Regan shares cutting-edge research on how MOTS-c boosts muscle recovery, enhances insulin sensitivity, activates AMPK, and even mimics the effects of exercise. He also explains how to naturally activate MOTS-c through exercise and sauna use, plus the optimal ways to stack peptides for maximum vitality. Listeners will learn practical strategies to benchmark their energy, improve recovery, and potentially reverse biological aging. Regan also shares personal stories of biohacking success and offers a new weekly challenge to supercharge your energy. Stay tuned for actionable insights and get ready to unleash your mitochondrial power! www.agelessfuture.com

Can one molecule preserve muscle, protect kidneys, and supercharge metabolism? In this episode of Healthy Choices, Dr. Jim LaValle joins Ray Solano to dive into OSO1—a next-gen therapeutic with wide-ranging benefits. From boosting AMPK to supporting mitochondria, OSO1 shows promise for everything from athletic recovery to age-related decline. Whether you're dealing with muscle loss or chasing peak performance, this episode is a game-changer. ---- In this episode of Healthy Choices, I sit down with Dr. Jim LaValle to talk about a breakthrough small molecule compound called OSO1. This isn't your typical supplement—it's a targeted therapeutic that supports your body's natural repair systems without relying on stimulants. We dive into how OSO1 helps preserve lean muscle, improve mitochondrial function, support glucose transport, and reduce inflammation—especially important for those on GLP-1 medications or dealing with age-related muscle loss. Dr. LaValle even shares how he uses OSO1 personally and why he sees it as a smarter, safer alternative to drugs like rapamycin. ---- Jim LaValle is a leading integrative and metabolic health expert with over 35 years of experience. He's treated thousands of patients—from elite athletes to those with chronic conditions—through his Metabolic Model for Health and founded the Metabolic Code platform to personalize care using lab data and lifestyle insights. He's been a consultant for top health brands, directed programs for the NFL Hall of Fame, and educated military special forces. A clinical instructor at George Washington University and award-winning educator, LaValle has authored 20+ books, made 1,000+ media appearances, and is recognized as one of the “50 Most Influential Pharmacists. ---- Website: https://www.jimlavalle.com Linkedin: https://www.linkedin.com/in/james-lavalle-1a6b8858/ Instagram: https://www.instagram.com/therealjimlavalle/?hl=en Facebook: https://www.facebook.com/p/Jim-LaValle-100062990514032/ ---- https://www.linkedin.com/in/ray-solano-76960463 https://www.instagram.com/pdlabs/ https://open.spotify.com/show/78tLVSbC28VnDbpw2SqiEg https://podcasts.apple.com/us/podcast/healthy-choices/id1203354304 https://www.iheart.com/podcast/256-healthy-choices-31040306/ ---- PODCAST Thank you for listening. Please subscribe and share. This podcast is produced by DrTalks.com drtalks.com/podcast-service/

V tomto hlubokém a strhujícím díle se vracíme zpět k biologickým kořenům vitality a klíčovému prvku našeho zdraví: energie. A pokud mluvíme o energii, musíme jít až k jejím generátorům – mitochondriím.Spolu s Vojtou a Kryštofem se ponoříš do fascinujícího příběhu o tom, jak mitochondrie nejsou jen „elektrárny buněk“, ale i hlídači našeho zdraví, strážci regenerace, regulátoři smrti a života – a v neposlední řadě i původní bakterie, která kdysi přežila pohlcení a započala jednu z nejstarších symbióz života.

Episode 189: Intermittent Fasting (Religious and Sports)Future Doctors Carlisle and Kim give recommendations about patients who are fasting for religious reasons, such as Ramadan. They also explain the benefits and risks of fasting for athletes and also debunked some myths about fasting. Dr. Arreaza add input about the side effects of fasting and ways to address them.    Written by Cameron Carlisle, MSIV (RUSM) and Kyung Kim, MSIV (AUC). Editing by Hector Arreaza, MD.You are listening to Rio Bravo qWeek Podcast, your weekly dose of knowledge brought to you by the Rio Bravo Family Medicine Residency Program from Bakersfield, California, a UCLA-affiliated program sponsored by Clinica Sierra Vista, Let Us Be Your Healthcare Home. This podcast was created for educational purposes only. Visit your primary care provider for additional medical advice.Introduction: In the last episode on fasting (#179), we explored how intermittent fasting (IF) can help manage type 2 diabetes by improving insulin sensitivity, promoting weight loss, and lowering inflammation. We discussed the benefits of methods like 16:8 time-restricted eating and the 5:2 meal plan, and even compared IF to medications like metformin. Today, we're bringing that science into real life. We'll talk about how people fast for religious reasons, like during Ramadan, how athletes use IF to stay in shape, and how we can use IF as a tool in family medicine to support community health and A1c control.Intermittent Fasting in Religious PracticeRamadan just ended on 3/30/25, but this is a great time to talk about the broader role of fasting in religion and health. Many faiths incorporate fasting into spiritual practice and understanding this can help us better support our patients.Islam (Ramadan): Ramadan is a month where Muslims fast from dawn to sunset, focusing on spiritual reflection and self-control. No food or drink is consumed during daylight hours. Despite this, studies have shown that with good planning, fasting during Ramadan does not significantly impair physical performance or metabolic health.Key health tips for patients observing Ramadan:Hydrate well between iftar (sunset) and suhoor (pre-dawn).Break the fast with dates and water to gently replenish energy and electrolytes.Eat balanced meals with complex carbs, protein, and healthy fatsAvoid greasy, heavy foods right after fastingLight exercise (such as a walk) after iftar is beneficialReview medications with a healthcare provider, especially for those on insulin or sulfonylureas.For example: Metformin should be taken when you break your fast and then again before dawn. If its an extended-release metformin, take it at night. Metformin does not cause significant hypoglycemia and can be continued during Ramadan. Basal insulin is advised to be given at Iftar, and the dose should be reduced by 25-35% if the patient is not well managed. And regarding the fast-acting insulin, it requires a little more reading, so you can look it up and learn about it. Judaism: In Judaism, fasting is practiced on days like Yom Kippur and Tisha B'Av, typically lasting 25 hours without food or water. These fasts are spiritual and reflective, and patients with medical conditions may seek guidance on how to participate safely.Christianity: Many Christians fast during Lent, either by abstaining from certain foods or limiting meal frequency. Some practice partial-day fasts or water-only fasts for spiritual renewal.A branch of Christianity known as The Church of Jesus Christ of Latter-day Saintsoften observe a 24-hour fast on the first Sunday of each month, known as Fast Sunday, where they abstain from food and drink and donate the cost of meals to charity. This practice is both spiritual and communal.Cameron: Fasting for religious reasons, when done safely, can align with IF protocols and be culturally sensitive for diverse patients in family medicine.IF in Athletes and PerformanceIntermittent fasting is gaining popularity in the sports world. Athletes are using IF to improve body composition, increase fat oxidation, and enhance metabolic flexibility. A recent study, known as the DRIFT trial and published in Annals of Internal Medicine, found that fasting three non-consecutive days a week led to more weight loss than daily calorie restriction. Participants lost an average of 6.37 pounds more over 12 months.Why? Better adherence. People found the 3-day fasting schedule easier to stick to than counting calories every day.Benefits of IF for athletes:Encourages fat burning (via AMPK activation and GLUT4 upregulation, listen to ep. 179).Helps maintain lean muscle while reducing fat.No major drop in performance when meals and workouts are timed properly.What are some practical tips?Schedule workouts during or just before eating windows.Eat protein-rich meals post-workout.Avoid intense training during long fasts unless adapted.Stay hydrated, especially in hot environments or endurance sports.Broader Applications and Myths Around IFHormonal Effects of IF: In addition to improving insulin sensitivity, IF also affects hormones such as ghrelin (which stimulates hunger, remember it as growling) and leptin (which signals fullness). Over time, IF may help the body regulate appetite better and reduce cravings. IF can also decrease morning cortisol levels, the stress hormone. That's why it's important to monitor sleep, hydration, and stress levels when recommending IF.Circadian Rhythm Alignment: Emerging research shows that aligning eating times with natural light/dark cycles—eating during the day and fasting at night—can improve metabolic outcomes. This practice, known as early time-restricted eating (eTRE), has been shown to lower blood glucose, reduce insulin levels, and improve energy use. Patients who eat earlier in the day tend to have better results than those who eat late at night.Myths and Clarifications on IF:-“Fasting slows metabolism” In fact, short-term fasting may boost metabolism slightly due to increased norepinephrine. -“You can't exercise while fasting.” Many people can safely train during fasted states, especially for moderate cardio or strength training. -“Skipping breakfast is bad.” For some, skipping breakfast is a useful IF strategy—as long as total nutrition is maintained. You can break your fast at 2:00 pm, it does have to be at 7:00 AM.What to Eat When Breaking a FastBreaking a fast properly is just as important as fasting itself. Whether it's after a Ramadan fast or a 16-hour fast, the goal is to replenish energy gently and restore nutrients.Ideal foods to break a fast:Dates and water: provide quick energy, potassium, and fiberSoups: lentil or broth-based soups are gentle on digestionComplex carbs: whole grains like brown rice or oatsLean proteins: chicken, fish, eggs, legumesFruits and vegetables: hydrate and provide fiberHealthy fats: nuts, avocado, olive oilProbiotics: yogurt or kefir for gut supportBalanced meals with carbs, protein, and healthy fats help the body transition smoothly back to a fed state.Using IF in Family Medicine and Community HealthIntermittent fasting can be a practical, cost-effective strategy in family medicine. In areas with high rates of obesity and diabetes, like Kern County, IF offers a lifestyle-based tool to improve metabolic health, especially in underserved populations. IF is free!How IF can help in family medicine:Lower A1c levels: improves insulin sensitivity and glucose controlPromote weight loss: decreases insulin resistance and inflammationReduce medication dependence: fewer meds needed over time for some patientsEncourage patient engagement: flexible and easier to follow than strict calorie countingFit diverse lifestyles: aligns with religious and cultural practicesAddress food insecurity: structured eating windows can help patients stretch limited food resourcesHow to apply IF in clinic:Start the conversation by asking if the patient has heard of IFRecommend simple starting points: 12:12 or 14:10Emphasize hydration and nutrient-dense mealsMonitor labs and symptoms, especially in diabetic patientsAdjust medications to avoid hypoglycemiaProvide follow-up and patient education handouts if possibleWhat if a patient isn't ready to try fasting?For those not ready to commit to intermittent fasting, one effective alternative is walking after meals. A simple 10–20 minute walk post-meal can help stimulate GLUT4 receptors in skeletal muscle, promoting glucose uptake independent of insulin. This reduces the demand on pancreatic beta cells and may help improve blood sugar control over time. This strategy is particularly useful for patients with insulin resistance or early-stage type 2 diabetes.Conclusion: Intermittent fasting is not one-size-fits-all, but it can be a powerful tool for both individual and community health. From Ramadan to race day, IF has a place in family medicine when used thoughtfully. Encourage patients to work with their healthcare providers to find an approach that fits their lifestyle, medical needs, and personal values. IF is a cost-effective toolEven without trying, every night you go to bed a little wiser. Thanks for listening to Rio Bravo qWeek Podcast. We want to hear from you, send us an email at RioBravoqWeek@clinicasierravista.org, or visit our website riobravofmrp.org/qweek. See you next week! _____________________References:American Academy of Family Physicians. (2022). "Intermittent Fasting: A Promising Treatment for Diabetes." AAFP Community Blog. https://www.aafp.org/pubs/afp/afp-community-blog/entry/intermittent-fasting-a-promising-treatment-for-diabetes.htmlHealthline. (2023). "What Breaks a Fast? Foods, Drinks, and Supplements." https://www.healthline.com/nutrition/what-breaks-a-fast.Sarri KO, Tzanakis NE, Linardakis MK, Mamalakis GD, Kafatos AG. Effects of Greek Orthodox Christian Church fasting on serum lipids and obesity. BMC Public Health. 2003 May 16;3:16. doi: 10.1186/1471-2458-3-16. PMID: 12753698; PMCID: PMC156653. https://pmc.ncbi.nlm.nih.gov/articles/PMC156653/.Shang, Y., et al. (2024). "Effects of Intermittent Fasting on Obesity-Related Health Outcomes: An Umbrella Review." eClinicalMedicine.https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(24)00098-1.Abaïdia AE, Daab W, Bouzid MA. Effects of Ramadan Fasting on Physical Performance: A Systematic Review with Meta-analysis. Sports Med. 2020 May;50(5):1009-1026. doi: 10.1007/s40279-020-01257-0. PMID: 31960369. https://pubmed.ncbi.nlm.nih.gov/31960369/.Theme song, Works All The Time by Dominik Schwarzer, YouTube ID: CUBDNERZU8HXUHBS, purchased from https://www.premiumbeat.com/.

Zum YouTube Video und YouTube Kanal gleich abonnieren und keine neue Folge mehr verpassenZusammenfassungIst die Angst vor gesättigten Fettsäuren und Milchfett überholt?

During this week's Metabolic Classroom lecture, Ben explores the metabolic power of cold therapy, explaining how brief, controlled exposure to cold can significantly enhance metabolic function.He starts with a deep dive into brown adipose tissue (BAT), which is rich in mitochondria and burns calories to generate heat. Cold exposure activates BAT through norepinephrine, leading to mitochondrial uncoupling and energy expenditure without producing ATP. Interestingly, even white fat can be transformed into metabolically active “beige” fat, increasing thermogenesis.Dr. Bikman then moves into how shivering muscle activity contributes to thermogenesis. Unlike BAT, muscle contraction generates heat while performing work. Shivering triggers glucose uptake, improves insulin sensitivity, and releases irisin, a hormone that stimulates thermogenic activity in fat tissue. He also discusses AMPK activation, which plays a key role in facilitating this glucose-burning process.The lecture then highlights a series of hormones influenced by cold, including FGF21 and adiponectin, which boost fat oxidation, enhance insulin sensitivity, and promote mitochondrial biogenesis. Ben reflects on the broader role of the autonomic nervous system, emphasizing how cold therapy improves both sympathetic and parasympathetic function, promoting nervous system flexibility and resilience.Dr. Bikman wraps up by comparing cold exposure methods—from face immersion and cold showers to cryotherapy and full-body ice baths. He strongly endorses full-body cold water immersion as the most effective strategy, especially when shivering occurs post-immersion. His personal recommendation is the Morozko Forge ice bath (he has no vested interest in this company), citing its sustained metabolic impact and practical benefit. He closes by urging viewers to consider cold therapy as a scientifically grounded tool to support overall metabolic health.Show Notes/References:For complete show notes and references, we invite you to become a Ben Bikman Insider subscriber. As a subscriber, you'll enjoy real-time, livestream Metabolic Classroom access which includes live Q&A after the lecture with Ben, ad-free podcast episodes, show notes and references, Ben's Research Reviews Podcast, and a searchable archive that includes all Metabolic Classroom episodes and Research Reviews. Learn more: https://www.benbikman.com#ColdTherapy #IceBath #BrownFat #MetabolicHealth #InsulinResistance #Mitochondria #ShiveringThermogenesis #AMPK #Irisin #FGF21 #Adiponectin #FatLoss #GlucoseControl #HealthOptimization #AutonomicNervousSystem #BeigeFat #WeightLossTips #Hormones #Biohacking #BenBikman #drbenbikman

Story at-a-glance Research shows mangoes significantly improve insulin sensitivity in people with chronic low-grade inflammation by activating genes that enhance the body's natural antioxidant defenses A 12-week study found that consuming freeze-dried mango pulp daily led to reduced blood glucose levels in obese adults At the cellular level, mango polyphenols activate the AMPK signaling pathway — the cell's master metabolic switch — promoting fat breakdown while suppressing the formation of new fat cells Regular mango consumption demonstrates measurable benefits for insulin function, with study participants showing lower fasting insulin concentrations and improved HOMA-IR scores compared to control groups Mango polyphenols help reduce inflammation by decreasing proinflammatory cytokines, suggesting benefits for preventing obesity-related diseases

Dr. Marc Grossman reveals the vital role of mitochondria, the powerhouses of your cells, in maintaining overall health and preventing diseases.Discover how healthy mitochondria can mitigate non-communicable diseases like heart disease, diabetes, and neurodegenerative disorders such as Alzheimer's. Learn about the origins of mitochondria, symptoms of mitochondrial dysfunction, and lifestyle changes that support mitochondrial health.Dr. Grossman shares insights on the importance of antioxidants like vitamins C, E, and CoQ10 in combating oxidative stress, a key factor in mitochondrial damage. Explore dietary recommendations, including the benefits of a colorful diet rich in fruits and vegetables, and the role of intermittent fasting in activating AMPK, an enzyme crucial for energy regulation.Uncover the power of herbs and supplements such as curcumin, berberine, B vitamins, and omega-3 fatty acids in enhancing mitochondrial function. Dr. Grossman also highlights the significance of regular exercise and maintaining a low-carb diet to support cellular energy production.For more expert advice on natural eye care and holistic health, visit NaturalEyeCare and DrGrossman2020. Subscribe to the Natural Eye Care Podcast for more episodes on maintaining healthy vision and overall well-being.

Welcome to the metabolism masterclass!Dr. Ben Bikman (Ph.D Professor BYU), a powerhouse in metabolism science, joins Dave to expose the truth about insulin resistance—the silent epidemic fueling obesity, chronic disease, and low energy. Forget the outdated calorie-counting nonsense (it doesn't work)—Dr. Bikman reveals how your hormones, not just your diet, control your metabolism and what you can do to reset it fast. From debunking diet myths to uncovering why some people can eat 400 grams of carbs and never gain fat (hint: it's not what you think), this episode unpacks the real science of fat storage, energy, and optimal health. Get ready for mind-blowing insights, metabolic hacks, and a new way to think about food, fasting, and longevity. What You'll Learn: • The #1 driver of insulin resistance—and why most doctors miss it • Why eating more fat (yes, really) could be the key to reversing metabolic dysfunction • How fasting, cold therapy, and red light impact your metabolism • The truth about carbs, seed oils, and why some people can't gain fat • How to tell if insulin resistance is wrecking your energy & health Resources: • Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Benjamin's new book How Not To Get Sick : https://a.co/d/aADlMWv • Benjamin's YouTube Page – https://www.youtube.com/@benbikman • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey's Website: https://daveasprey.com • Dave Asprey's Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com SPONSORS: -Lumiram | Go to http://healthlighting.com/dave to save 10% on your order. -Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. Timestamps: 00:00 Trailer 00:52 Introduction to Dr. Benjamin Bikman 02:20 The Battle Against Conventional Dietetics 04:12 Understanding Insulin Resistance 06:29 The Two Paths to Insulin Resistance 10:19 Fasting and Metabolic Health 14:11 Insulin and Cognitive Enhancement 18:16 Identifying Insulin Resistance 30:12 The Role of Insulin in Fat Storage 42:04 Understanding Glucose and Insulin Dynamics 42:26 The Role of Exercise in Glucose Regulation 42:54 AMPK and Muscle Contraction 45:21 Calories In, Calories Out Debate 46:15 The Myth of Calorie Counting 50:13 Ketosis and Metabolic Rate 51:14 Intermittent Fasting and Muscle Preservation 55:21 Insulin Resistance and Ketogenic Diets 01:02:04 Circadian Rhythm and Insulin Sensitivity 01:08:08 Environmental Toxins and Insulin Resistance 01:13:03 The Impact of Seed Oils on Insulin Resistance 01:19:22 Final Thoughts and Resources See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Timestamps0:37 - Using Human Growth Hormone (HGH) for fat loss: what it does, common doses (fat loss vs muscle growth), fasted cardio when using HGH, managing side effects, administration strategies17:15 - Can you become an IFBB pro without HGH use? Synergy of HGH with anabolics & can taking HGH mean you need to take less anabolics to grow at the same rate as you wound on a higher dose of anabolics?22:23 - Role of insulin and insulin sensitivity with body composition outcomes27:37 - Metformin: mechanism of action, common doses, side effects, Berberine vs Metformin, why people don't need to worry about AMPK agonism, administration protocols37:30 - Yohimbine HCL - mechanism of action, common doses, side effects, administration protocols42:31 - L-Carnitine - mechanism of action, common doses, side effects; injectable vs oral, administration protocols, acute performance benefits Team Evil GSP - https://teamevilgsp.com/Hire Mircea - https://teamevilgsp.com/team/mircea-balaj/Membersite - https://members.teamevilgsp.com/Mircea's Instagram - https://www.instagram.com/mirceabjr/Apply For Coaching - https://bit.ly/3QpfduxGet My FREE Programs - https://bit.ly/4fF4wPcMy Instagram - https://bit.ly/3Uy2zfbMacroFactor Diet Tracking App (Use code PEELER for a 2-Week FREE Trial!) - https://bit.ly/49Vz2ADLeviathan Nutrition (Code: ADAM10) - https://leviathan-nutrition.com/Built Bar (code PEELER for 10% off) - https://builtbar.com/

Dr. Bikman's Metabolic Classroom lecture this week explores peptides and their effects on metabolism, fat loss, muscle growth, and overall health.Ben begins by defining peptides as short chains of amino acids that act as signaling molecules in the body. While some peptides occur naturally, others are synthetically developed for therapeutic purposes. He explains that peptides are gaining popularity in fitness, anti-aging, and metabolic health, influencing fat loss, muscle repair, insulin sensitivity, and even skin regeneration. He also introduces collagen peptides, highlighting their unexpected metabolic benefits, including their influence on GLP-1 and gut microbiome health.Ben then categorizes peptides based on their primary functions. For fat loss, peptides like CJC-1295 and Tesamorelin work by stimulating growth hormone and IGF-1, promoting fat breakdown while preserving muscle mass. Another peptide, Melanotan-2, originally known for increasing melanin, has been found to suppress appetite by affecting the melanocortin system. He also discusses peptides like Ipamorelin, which help enhance muscle recovery and growth by selectively increasing growth hormone secretion without affecting other pituitary hormones.In the anti-aging and skin health category, Thymosin Beta-4 stands out for its ability to enhance wound healing and tissue repair. Dr. Bikman also highlights the unexpected metabolic role of collagen peptides, explaining how they can increase GLP-1 levels, improve insulin sensitivity, and even activate AMPK, a crucial metabolic regulator involved in fat breakdown and cellular repair.Finally, he touches on how peptides are administered—most commonly via subcutaneous injections, though some peptides can be absorbed sublingually or applied topically.He cautions that not all peptides are created equal, warning against low-quality or counterfeit products. Ben emphasizes the need for high-quality sourcing and careful monitoring, as some peptides affect hormone levels and require medical supervision.Dr. Bikman concludes that peptides hold immense potential for metabolic health, fitness, and longevity, but should be used wisely and responsibly.Show Notes/References:For complete show notes and references referred to in this episode, we invite you to become a Ben Bikman Insider subscriber. As a subscriber, you'll enjoy real-time, livestream Metabolic Classroom access which includes live Q&A with Ben, ad-free Metabolic Classroom Podcast episodes, show notes and references, Ben's Research Reviews Podcast, and a searchable archive that includes all Metabolic Classroom episodes and Research Reviews. Learn more about becoming an Insider on our website: https://www.benbikman.com Hosted on Acast. See acast.com/privacy for more information.

Dr Glenn McConell chats with Dr Tommy Lundberg from the Karolinska Institute in Stockholm, Sweden. He is an expert on resistance training (RT) and has focussed on the effect of concurrent training on exercise adaptations. That is, does doing concurrent resistance and endurance training affect the responses to resistance and endurance training compared to doing either alone. His research has specifically focused on the effects of endurance training on resistance training adaptations although we also discussed the effect of resistance training on endurance training adaptations. It appears that in many people concurrent training has either no interfering effect or may even be beneficial. However there is some limited research that endurance training, although not affecting hypertrophy, may reduce strength and/or speed of contraction. He has also done a lot of work on biological males been involved in female sports (which will be converted in a future podcast). I found it a very interesting chat. Enjoy! X: @TLexercise. 0:00. Introduction 3:03. Tommy's background 5:25. Aland Islands 7:25. What is concurrent training? 9:40. Resistance training (RT) can benefit endurance performance 13:35. Does RT affect injuries? 15:05. The amount/volume of training and concurrent training 18:32. Little effect of endurance training on hypertrophy but might effect strength 21:30. Glenn's frustrations at the gym 24:15. Single-leg research studies vs whole body exercise 31:20. AMPK and metabolism etc 34:00. Potential mechanisms involved 35:40. Interference of endurance on strength hasn't been clearly shown 38:00. RT can improve endurance performance and economy 41:10. Specificity of RT adaptations 45:55. Running straight after the gym 48:55. How much RT is enough/sufficient/optimal 51.20. Benefits of circuit training 53:05. Endurance exercise interfering with strength/contraction speed 54:20. Relationship between muscle size and strength 59:05. Explosive RT best for endurance exercise 1:04:35. Order of the concurrent training 1:06:35. Arterial stiffness/health and concurrent training 1:10:25. Team sports and concurrent training 1:12.08. Different sports a concurrent training 1:13:05. Mechanisms: gene expression etc 1:16:22. Fatigue and concurrent training 1:17:40. If short on time what exercise would you recommend? 1:19:55. Sex differences? 1:20:45. Age effects? 1:21:20. Controversies in the field 1:24:25. Things that influencers can get wrong 1:25:45. Other areas that he is investigating 1:27:50. Anti inflammatories can reduce resistance training gains 1:30:08. Takeaway messages 1:31:14. Outro Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise's effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all. The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University. He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9). Connect with Inside Exercise and Glenn McConell at: Twitter: @Inside_exercise and @GlennMcConell1 Instagram: insideexercise Facebook: Glenn McConell LinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460 ResearchGate: Glenn McConell Email: glenn.mcconell@gmail.com Subscribe to Inside exercise: Spotify: shorturl.at/tyGHL Apple Podcasts: shorturl.at/oFQRU YouTube: https://www.youtube.com/@insideexercise Anchor: https://anchor.fm/insideexercise Google Podcasts: shorturl.at/bfhHI Anchor: https://anchor.fm/insideexercise Podcast Addict: https://podcastaddict.com/podcast/4025218 Not medical advice

EP. 190: What if the key to not dying early—or at least living vibrantly—boils down to one thing? Metabolic health. In this episode, I sit down with Dr. Ben Bikman, one of the world's leading experts on insulin resistance & metabolic health. Dr. Bikman is a professor at Brigham Young University and the author of Why We Get Sick, a groundbreaking book that exposes how modern lifestyles are fueling diabetes, obesity, and heart disease. We break down: Why insulin resistance is the root cause of so many chronic conditions The real impact of GLP-1s on metabolism and fat cells The latest cutting-edge research on muscle and GLP1 from Dr. Bikman's lab at BYU What you can do today to take back control of your metabolic health How Insulin Resistance Fuels Chronic Disease—and What to Do About It The Surprising Role of Fat Cells in Metabolism and Hormone Balance Why ‘Eat Less, Move More' Fails Most People—and What Works Instead GLP-1s and Satiety: The Science Behind Appetite and Metabolic Control Cutting-Edge Metabolic Health Research from BYU That Could Change Everything Simple, Science-Backed Strategies to Boost Testosterone Naturally If you care about your hormones, metabolism, and long-term vitality, this episode is a must-listen. Join my FREE 21-Day Strength & Resilience Challenge to get started: www.drtyna.com/strengthandresilience Sponsored By: Timeline Timeline is offering 10% off your order of Mitopure. Go to timeline.com/drtyna.  Puori Go to Puori.com/drtyna and use code DRTYNA to get 20% off Purity Woods Go to puritywoods.com/DRTYNA or enter DRTYNA at checkout for 27% off Sundays Get 40% off your first order of Sundays. Go to sundaysfordogs.com/DRTYNA and use code DRTYNA at checkout. BIOptimizers For an exclusive offer go to bioptimizers.com/drtyna and use promo code DRTYNA On This Episode We Cover:  00:00:00 - Introduction 00:01:57 - Teaching at BYU 00:03:32 - Dr. Ben's books 00:05:42 - Defining insulin resistance 00:10:14 - Insulin resistance and chronic disease 00:17:50 - Viruses and fat cells 00:19:56 - Fast vs. slow insulin resistance 00:26:21 - Overfilled fat cells 00:28:24 - Issues with the “Eat less & exercise more” approach 00:31:27 - Genes and metabolic health 00:32:12 - Satiety & GLP-1 response 00:37:25 - Appetite control vs. suppression 00:39:22 - GLP-1 dosing 00:42:33 - Hormones and metabolism 00:48:13 - Estrogen replacement therapy and testing 00:51:57 - AMPK, mTOR, and supplementation 00:57:57 - Metformin study 00:59:46 - Easiest ways to increase testosterone Further Listening: 10 Health Trends We Are Ditching in 2025 | Solo Kick Off 2025 with Strength, Resilience & Purpose | Quick & Dirty The Surprising Health Connections Between You and Your Dog | Quick & Dirty Check Out Dr. Ben: Instagram Website Books Disclaimer: Information provided in this podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional, or any information contained on or in any product. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before taking any medication or nutritional, herbal or other supplement, or using any treatment for a health problem. Information provided in this blog/podcast and the use of any products or services related to this podcast by you does not create a doctor-patient relationship between you and Dr. Tyna Moore. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent ANY disease.

Balancing AMPK and mTOR for Optimal Aging and Performance Episode Summary: In this episode, we dive into the fascinating world of cellular pathways—AMPK and mTOR—and how they influence mitochondrial function, muscle protein synthesis, and the aging process. Discover how to strategically balance these pathways to optimize metabolic health, overcome anabolic resistance, and support muscle maintenance as we age. Learn actionable tips for nutrition, exercise, fasting, and recovery to enhance your body's performance and longevity. What You'll Learn in These Episodes: The role of AMPK in fat oxidation, autophagy, and mitochondrial health. Why mTOR is crucial for muscle protein synthesis and recovery. How to cycle between AMPK and mTOR activation daily and weekly. Nutrition strategies for protein timing, carbohydrate fueling, and fat balance. Recovery practices like fasting, heat exposure, and cold therapy to optimize cellular health. Supplement recommendations to support both pathways. Key Takeaways: AMPK-focused mornings: Fasted low-intensity exercise and nutrient-dense meals for fat oxidation and autophagy. mTOR-focused midday: Strength training and leucine-rich protein for muscle growth and recovery. Weekly cycling: Alternate between AMPK and mTOR-dominant days to maintain balance. Optimize aging by addressing anabolic resistance with protein-rich meals and targeted recovery practices. Resources Mentioned: Supplements: Berberine, resveratrol, leucine-rich protein, EAAs, and creatine. Recovery tools: Cold plunges, sauna, and intermittent fasting. Nutrition insights: High-quality protein sources, carb timing, and omega-3 fats. Who This Episode Is For: This episode is perfect for anyone looking to optimize their body composition, improve mitochondrial function, and thrive as they age—whether you're an athlete, health enthusiast, or just looking to stay strong and resilient. Connect With Us: Website: www.debbiepotts.net Social Media:  Coach Debbie Potts Don't forget to subscribe, leave a review, and share this episode with someone who's passionate about living their best life!

Chris Duffin sits down with expert guest Anthony Castor to delve deep into the fascinating world of insulin mimetics, glucose metabolism, and their implications for overall health and aging. The conversation kicks off with an examination of metformin's widespread use in diabetes management and its controversial potential benefits in cancer prevention, as highlighted in a recent study that casts doubt on its anti-cancer efficacy. Anthony and Chris explore the intricacies of balancing key cellular pathways—AMPK and mTOR—and their roles in muscle metabolism and aging. They discuss how the AMPK pathway acts as a guardian of energy preservation in the cell, especially under conditions of low nutrient availability, while mTOR is pivotal for muscle protein synthesis and energy expenditure. They also touch upon the impact of gut microbiome shifts on insulin sensitivity and how products like berberine and metformin can influence these pathways, sometimes to the detriment of muscle mass gain. Metformin and Gut Microbiome Positive impacts of metformin on gut microbiome GI disturbances related to insulin mimetics Role of AMPK signaling in energy preservation and muscle protein synthesis Benefits of products like berberine, banaba leaf extract, and alpha lipoic acid Hormonal support and muscle mass considerations   This episode of the ARCHITECT of RESILIENCE podcast is available on Apple, Spotify & YouTube, and is sponsored by  @marekhealth : Performance. Longevity. Optimization.

Report: US will trail other nations in life expectancy by 2030Obesity rates a contributing factor to decreased life expectancy in the USWhat are your views about the use of AMPK? 

Ads for Ozempic, Wegovy, and Zepbound are all over our televisions (at least here in the US). But are these injectables really the key to losing weight and keeping it off? In this episode, I'm digging into all of the science surrounding these popular weight-loss drugs, including - the differences between each of them - how they work (and don't work) - the unwanted side effects that come from using these medications - natural ways to increase your body's production of GLP-1 ... and more! --- Show Notes: References: Coursework from Master's in Human Nutrition & Functional Medicine Program at the University of Western States Efficacy and safety of GLP-1 receptor agonists versus SGLT-2 inhibitors in overweight/obese patients with or without diabetes mellitus: a systematic review and network meta-analysis Weight regain and cardiometabolic effects after withdrawal of semaglutide: The STEP 1 trial extension Weight Loss Medications: GLP-1 Agonists and How They Work How Much Does Ozempic Cost? With & Without Insurance Zepbound vs. Ozempic: 5 Differences Between These Weekly Injections What Are Incretin Mimetics, and How Do They Affect Weight Loss, Blood Sugar, and Type 2 Diabetes? Strategies for minimizing muscle loss during use of incretin‐mimetic drugs for treatment of obesity The Positive Effects of Yerba Maté (Ilex paraguariensis) in Obesity Anti-obesity effects of Yerba Mate (Ilex Paraguariensis): a randomized, double-blind, placebo-controlled clinical trial The effect of psyllium on fasting blood sugar, HbA1c, HOMA IR, and insulin control: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials Soluble fibers from psyllium improve glycemic response and body weight among diabetes type 2 patients (randomized control trial) Increased glucagon-like peptide-1 secretion may be involved in antidiabetic effects of ginsenosides Modulation of glucagon-like peptide-1 release by berberine: in vivo and in vitro studies The effects of berberine on inflammatory markers in Chinese patients with metabolic syndrome and related disorders: a meta‑analysis of randomized controlled trials Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins A High Dose of Dietary Berberine Improves Gut Wall Morphology, Despite an Expansion of Enterobacteriaceae and a Reduction in Beneficial Microbiota in Broiler Chickens Berberine enhances the AMPK activation and autophagy and mitigates high glucose-induced apoptosis of mouse podocytes Curcumin induces secretion of glucagon-like peptide-1 through an oxidation-dependent mechanism --- 135: What You Should Know Before Starting Ozempic Sign up for a 1:1 Discovery Call Join the Compass Method DIY Program Jump inside my Rock the Bloat Minicourse Get my Core-Gi Workout Program with the exclusive listener discount! Join my Brain Rewiring Masterclass You can learn more about me by following on IG @imperfectlypaigewellness or by checking out my blog, freebies, and offers on my website: https://imperfectlypaigewellness.com Please share with #PaigeTalksWellness to help get the word out about the show - and join the Imperfect Health Fam over on Facebook.

In this episode of the Get Lean, Eat Clean podcast, I delve into the critical pathways of mTOR and AMPK, explaining their roles in muscle growth, energy management, and overall health.I emphasize the importance of balancing these pathways for optimal performance and provide practical tips for integrating them into fitness routines.The discussion highlights how understanding these molecular pathways can empower individuals to achieve their health and wellness goals effectively.Click the link below to get started!https://calendly.com/bdgryn/15minIf you love the Get Lean Eat Clean Podcast, we'd love for you to subscribe, rate, and give a review on Apple Podcasts and Spotify! Until next time!Links:Watch Get Lean Eat Clean podcast video episodes on YouTube!YouTube.com/@briangryn3680How to Take Simple Steps to Reclaim the Body, Energy, and Strength You Had 10-15 Years Ago Using My Stepladder System:https://www.stepladdersystem.com/B.rad Whey Protein Isolate Superfuel:The Best Protein on The Planet! Available in Two Delicious Flavors: Vanilla Bean and Cocoa BeanUse Coupon Code glec10off for 10% off your order!https://a.co/d/731gssVFifth (5th) Element Mineral Rich Living Sea Blend:This is the World's most pure, best tasting and broadest spectrum unrefined, solar dehydrated, hand harvested Sea Salt!This artisan salt is exactly suited for hydrating the body's cells from head to toe. Just melt a small amount into the water you drink and enjoy a great tasting elixir that supplies your body the minerals it is craving.This supports a very healthy cardiovascular system that improves daily the longer you consume it in your water.https://tracking.activationproducts.com/JRD6SLRT/2H6QR9N/Upgraded Formulas hair mineral test (Coupon Code: GETLEAN10) :https://www.upgradedformulas.com/pages/kit?rfsn=6677062.f87541&utm_source=refersion&utm_medium=affiliate&utm_campaign=6677062.f87541X3Bar: Variable Resistance Technology allows for a full body workout inonly 10 minutes! Use discount code "Save50" for $50 off your purchase!https://www.anrdoezrs.net/click-100286468-13650338| Listen to the Get Lean Eat Clean Podcast |►Apple Podcasts | https://podcasts.apple.com/us/podcast/get-lean-eat-clean/id1540391210►Spotify | https://open.spotify.com/show/0QmJzYZsdV6tUNbDxaPJjS| Connect with Brian |►Website | https://www.briangryn.com►Instagram | https://www.instagram.com/bdgryn►Facebook | https://www.facebook.com/getleanandeatclean►Twitter | https://twitter.com/grynnerwinner

Ever wondered how you can achieve the health benefits of fasting without actually abstaining from food? Join us as we explore this intriguing concept with Dr. Joseph Anton, CEO of L-Nutra. Dr. Anton introduces us to the innovative idea of physiological or cellular fasting, where specific nutritional choices can simulate the body's fasting state. We delve into the popularity and benefits of intermittent fasting, particularly the 16-hour fasting pattern, and examine how our bodies switch from glycogen depletion to fat burning and cellular rejuvenation through autophagy during extended fasting periods.In an insightful comparison, we pit fasting against the ketogenic diet, scrutinizing their molecular impacts on pathways like mTOR, AMPK, and RAS. Dr. Anton breaks down the complex stress response triggered by fasting, which not only downregulates growth pathways but also boosts growth hormone, leading to muscle rejuvenation and cellular autophagy. While the ketogenic diet has its merits, particularly for short-term benefits, it falls short of the deep cellular and longevity advantages that fasting offers. We highlight the importance of balanced, intermittent fasting approaches for achieving optimal health and longevity.We examine the transformative potential of the fasting mimicking diet through Prolon, a revolutionary product designed to maintain muscle while promoting fat loss. Dr. Anton shares the physical and mental perks, including enhanced energy, performance, mental clarity, and skin rejuvenation. We discuss how Prolon can seamlessly fit into long-term health plans, particularly for those with metabolic conditions, and even explore its potential for insurance coverage. Tune in for groundbreaking health insights and actionable advice that could change your life.Free sample chapter -Lies I Taught In Medical School :https://www.robertlufkinmd.com/lies/Our sponsors: Siphox Health, at-home health testing (15% off):https://pathlongevity.com/Prolon & the Fasting Mimicking Diet (20% off ):https://prolonlife.com/LufkinSuperpower, skip the waitlist HERE:https://superpower.com/lufkin *** CONNECT***Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmdInstagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/Facebook: https://www.facebook.com/robertlufkinmd Threads: ...

Does the diabetes drug metformin have an anti-aging effect?

Today's episode has me talking all about the critical role of estrogen in managing menopausal health and metabolism. We unravel common misconceptions, such as the idea that progesterone deficiency is the primary cause of menopausal symptoms, and discuss estradiol's influence on the thermoneutral zone. By maintaining estrogen levels within the "Goldilocks zone," we explore its impact on metabolic health, insulin resistance, and inflammation. Additionally, I explain estradiol's interaction with serotonin and dopamine, which affects mood and appetite regulation. I also emphasize the importance of hormonal balance, especially when considering hormone replacement therapy, and explore the roles of acylation stimulating protein and progesterone in fat storage.   In this episode: How estrogen plays a crucial role in metabolism during menopause. Why estradiol is significant in regulating the thermoneutral zone, affecting hot flashes. What the "Goldilocks zone" of estrogen is and why it's important to be within it. How estrogen dominance can lead to increased fat storage and insulin resistance. Why decreased estrogen levels increase the risk of metabolic diseases like type 2 diabetes. How estradiol supports insulin function and stabilizes blood sugar levels. The interaction of estradiol with cortisol and progesterone impacts glucose metabolism. How estradiol influences emotional well-being through serotonin and dopamine interaction. Why estradiol modulates appetite and satiety signals, aiding in weight management. The role of acylation stimulating protein in fat storage during the menstrual cycle. Why estradiol's activation of AMPK enhances energy expenditure and reduces appetite. How estradiol supports mitochondrial health, energy production, and muscle growth. Why maintaining estradiol levels is essential for reducing systemic inflammation. The potential benefits of estrogen replacement therapy in managing menopausal weight gain.   GET $400 OFF YOUR JASPR AIR PURIFIER FROM NOV 12th - 26th with coupon code hormonesolution!! https://jaspr.co/hormonesolution   Try Hormone Balance by Essentially Whole at https://drmariza.com/karen and use code KAREN10 at checkout for 10% off a one time purchase OR 20% for life with Subscribe and Save.   Get 10% off your UVB VItamin D Red Light Mitolux Box here with coupon code KM10!   Are you in peri or post menopause and looking to optimize your hormones and health? At Hormone Solutions, we offer telemedicine services and can prescribe in every U.S. state, as well as in British Columbia, Alberta, and Ontario in Canada.   Visit karenmartel.com to explore our comprehensive programs: Bioidentical Hormone Replacement Therapy Individualized Weight Loss Programs  Peptide Therapy for weight loss    Interested in our NEW Peptide Weight Loss Program? Join today and get all the details here.   Join our Women's Peri and Post Menopause Group Coaching Program, OnTrack, TODAY!   Your host: Karen Martel Certified Hormone Specialist, Transformational Nutrition Coach, & Weight Loss Expert   Karen's Facebook Karen's Instagram

What is this fascinating enzyme that acts as a universal fuel gauge?

While I've discussed longevity and aging in multiple episodes on this platform, I thought it was time for a deep dive and explain some of the nuanced details about aging and lifespan. We'll cover the primary theory of aging, the hallmarks of aging, the physiological process of AMPK and mTOR and their relationship, and much more! Topics include:   - Simplifying the Science of Aging - What We'll Cover Today - Primary Theory of Aging - The 9 Hallmarks of Aging - Stem Cell Therapy - Explaining DNA Further - Remember CD's? - 2 Pathways to Aging - Are Sacrifices and Tradeoffs Necessary? - AMPK and mTOR Relationship - Measuring Aging - Longevity Supplements ----------  My Live Program for Coaches: The Functional Nutrition and Metabolism Specialization  www.metabolismschool.com ----------  Subscribe to My Youtube Channel:  https://youtube.com/@sammillerscience?si=s1jcR6Im4GDHbw_1 ----------     [Free] Metabolism School 101: The Video Series http://www.metabolismschool.com/metabolism-101     ----------     Grab a Copy of My New Book - Metabolism Made Simple     ----------   Stay Connected:     Instagram: @sammillerscience     Youtube: SamMillerScience     Facebook: The Nutrition Coaching Collaborative Community     TikTok: @sammillerscience       ---------- “This Podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast and the show notes or the reliance on the information provided is to be done at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment and is for educational purposes only. Always consult your physician before beginning any exercise program and users should not disregard, or delay in obtaining, medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions. By accessing this Podcast, the listener acknowledges that the entire contents and design of this Podcast, are the property of Oracle Athletic Science LLC, or used by Oracle Athletic Science LLC with permission, and are protected under U.S. and international copyright and trademark laws. Except as otherwise provided herein, users of this Podcast may save and use information contained in the Podcast only for personal or other non-commercial, educational purposes. No other use, including, without limitation, reproduction, retransmission or editing, of this Podcast may be made without the prior written permission of Oracle Athletic Science LLC, which may be requested by contacting the Oracle Athletic Science LLC by email at team@sammillerscience.com. By accessing this Podcast, the listener acknowledges that Oracle Athletic Science LLC makes no warranty, guarantee, or representation as to the accuracy or sufficiency of the information featured in this Podcast."

In this episode we discuss: The criticism of Georgi regarding estrogen and cancer The major point that Siim Land is missing when it comes to increasing NAD+ Why we think Dr. Berg is completely wrong on serotonin Nutrition With Judy's suggestion that thyroid issues on a carnivore diet are not caused by the lack of carbohydrates, and why we think this isn't the case Dave Asprey's recommendation to drink orange juice and whether it's for the right reasons Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide   The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/   Danny's Telegram: https://t.me/dannyroddy   Danny's Substack: https://dannyroddy.substack.com/   Timestamps: 0:00 – intro 1:10 – whether estrogen is a carcinogen  6:13 – estrogen's role in driving weight gain and chronic diseases such as cancer, Alzheimer's disease, and Type 2 Diabetes  8:03 – the dangers of synthetic progesterone (progestin) use  10:14 – the difference between estrone and estradiol and the problems with estrogen testing  16:14 – whether estrogen therapy should be used in post-menopausal women  17:17 – the difference between oral and transdermal estrogen use  24:44 – the connection between inflammation and estrogen production  27:57 – why estrogen levels are not actually low in post-menopausal women  37:59 – our take on Siim Land's post on NAD+ and mitochondrial uncoupling  48:25 – why intentionally seeking hormetic responses, like the activation of heat-shock proteins, should be avoided  50:37 – which form of CoQ10 is better: ubiquinone or ubiquinol  53:34 – what Siim Land and many others get wrong when it comes to raising NAD+   55:44 – does fasting and AMPK upregulation cause cancer?  1:00:29 – fat fuels cancer and why not to restrict sugar for cancer  1:09:56 – Dr Berg's take that serotonin is the “happy hormone” – why we disagree  1:19:06 – serotonin's role in driving chronic diseases and conditions including depression, anxiety, IBS, and cancer  1:27:24 – Nutrition with Judy claims that the low thyroid levels generally seen on the carnivore diet have nothing to do with a lack of carbohydrates  1:39:01 – how the rate of living theory changed mainstream medicine's view that thyroid health is important  1:45:37 – how excessive exercise raises stress hormones, setting you up for weight regain  1:51:30 – why the combination of fasting and exercise is detrimental to our health  1:53:44 – how estrogen is used to fatten animals   2:02:42 – why Dave Asprey is talking about endotoxin and orange juice  2:07:00 – whether the sugar in orange juice feeds bacteria and increases endotoxin  2:09:40 – why the low-carb trend keeps resurfacing, despite the growing evidence against it  2:14:41 – where to find Georgi and IdeaLabs 

We're thrilled to have Anthony Castor on the show. We'll be discussing a groundbreaking compound, SLU-PP 332, which uniquely targets estrogen-related receptors to enhance energy metabolism, aid fat loss, and improve mitochondrial health. Anthony will explain the fascinating concept of mitochondrial biogenesis and how SLU-PP 332 mimics the benefits of exercise by activating nuclear receptors and promoting metabolic efficiency. Hear about his personal experience with this potent compound, the protocols he followed, and the impressive outcomes he observed in energy, mental clarity, and health biomarkers. We'll also delve into the science behind cellular mechanisms, such as the activation of AMPK and its impact on energy states, fat burning, and muscle protein synthesis. Plus, we'll highlight the importance of foundational health practices and the latest on our collaboration in developing research compounds to enhance health and performance. Stay tuned as we explore the exciting potentials of SLU-PP 332 and invite you to join our community for more insights and support. Let's get started on this journey towards resilience and optimal health! This episode of the ARCHITECT of RESILIENCE podcast is available on Apple, Spotify & YouTube, and is sponsored by @marekhealth : Performance. Longevity. Optimization.

Episode 179: Impact of intermittent fasting Impact on T2DMFuture Dr. Carlisle explains the physiology of fasting and how it can help revert type 2 diabetes. Dr. Arreaza adds details on how to do intermittent fasting. Written by Cameron Carlisle, MSIV, Ross University School of Medicine. Comments and edits by Hector Arreaza, MD, FAAFP.You are listening to Rio Bravo qWeek Podcast, your weekly dose of knowledge brought to you by the Rio Bravo Family Medicine Residency Program from Bakersfield, California, a UCLA-affiliated program sponsored by Clinica Sierra Vista, Let Us Be Your Healthcare Home. This podcast was created for educational purposes only. Visit your primary care provider for additional medical advice.What is type 2 Diabetes Mellitus (T2DM)?-Type 2 Diabetes Mellitus (T2DM) is a metabolic disorder characterized by insulin resistance and impaired glucose regulation. -This impaired regulation can lead to hyperglycemia, contributing to complications in a myriad of organs: heart, kidneys, eyes, nerves, etc. (target organs). According to the CDC, more than 38 million Americans have T2DM (about 1/10 people). -Multiple mechanisms are believed to contribute to insulin resistance in obese patients with T2DM, such as increased lipid deposition throughout the body and systemic inflammation.What is Intermittent Fasting (IF)? Intermittent fasting (IF) has recently gained popularity as a dietary approach for health benefits, but it has been around for thousands of years. IF is an eating pattern that alternates between eating and fasting (no calories consumed) over a specific period of time. When you are fasting, you are allowed and encouraged to keep drinking water and non-caloric drinks, like coffee, tea, and even homemade bone broth.-According to the International Food Information Council Foundation (IFIC), 10% of Americans engage in IF daily. -According to Mark Mattson, a neuroscientist and IF expert for over 25 years, a mechanism called “metabolic switching” is seen with IF. This is when your body runs out of glucose and starts burning fat (i.e., fatty oxidation). These metabolic changes can help protect your organs and reduce the risk of chronic conditions, like T2DM. Common IF methods: Time-restricted eating: Most common method, involves eating within a specific time frame (e.g., the 16:8, 18:6, 12:12 method is also common.  [16:8 means you have 16 hours of fasting and 8 hours of eating.]Alternate-day fasting: Alternating between fasting days and normal eating days.  [Find more info in The Complete Guide to Fasting, by Jason Fung, who is a nephrologist, he explains that alternate-day is basically eating every other day, which would give 36 hours of fasting, but if you are a beginner you can try a 24 hours fasting, in short, not eating breakfast any day of the week and having lunch 4 days a week, and dinner every night.]5:2 diet (aka periodic fasting): Maintaining a normal diet for 5 days, with 2 days (usually non-consecutive) of caloric restriction (25% of normal caloric intake; e.g., 500 calorie meal). IF is strongly believed to improve metabolic health in individuals with T2DM by reducing insulin resistance via increasing insulin sensitivity, promoting weight loss (patients with obesity and DM… AKA patients with diabesity), and enhancing lipolysis via fat oxidation.While fasting, the body goes through several phases that affect how energy is metabolized. Between 0 and 4 hours after eating, the body enters a feeding state, using glucose as its main energy source. After fasting for 12-16 hours, the body enters ketosis and starts to use fat for energy. Within 24-36 hours, autophagy begins, a process that recycles damaged cells and allows for cellular repair. This process can have great benefits for people with T2DM, such as improved insulin sensitivity and glucose regulation. Pathophysiology of Implementing IF in T2DM. -IF is thought to increase insulin sensitivity by decreasing fatty tissue in the body (i.e., visceral adipose tissue), which is correlated to insulin resistance. Insulin resistance is defined as higher than normal circulating insulin levels needed for a glucose lower response, which is thought to be the culprit for the generation of T2DM. It means you need high levels of insulin to keep glucose normal. -Obesity is an important risk factor for T2DM. Visceral adipose tissue functions as an organ via the secretion of adipokines (cytokines or cellular messengers produced by adipose tissue): leptin and adiponectin. Leptin: proinflammatory, leading to chronic inflammation. Patients with higher BMI levels and increased insulin resistance were found to have increased leptin levels.[Leptin is a good hormone at normal levels, but there is leptin resistance] Adiponectin: anti-inflammatory and antidiabetic effects. Higher adiponectin levels result in decreased hepatic gluconeogenesis, enhanced glucose absorption, and enhanced skeletal muscle and hepatic fatty acid oxidation. Levels drop as visceral fat increases. -Dr. López-Jaramillo, a Colombian endocrinologist and researcher, and colleagues published a review in 2014 examining the imbalance in the levels of leptin and adiponectin in individuals with metabolic syndrome. This imbalance (increase in leptin and decrease in adiponectin) is linked to obesity and insulin resistance, which has been shown to increase the risk of T2DM. It has been shown that IF has resulted in the reduction of leptin levels and increased levels of adiponectin, which leads to decreased insulin resistance and increased insulin sensitivity. -IF allows pancreatic beta-cells to rest by not having to secrete insulin constantly. This allows the beta-cells of the pancreas to improve in function over time. In addition, IF has been shown to lead to noticeable weight loss and loss in body fat, both of which play an important contribution in managing T2DM. Research demonstrates that this weight loss increases insulin sensitivity and decreases the need for insulin therapy, making IF a powerful approach for improving metabolic health. AMP-Activated Protein Kinase (AMPK) and Its Role in IF and T2DM Recent research has highlighted an important enzyme seen in IF, AMP-activated protein kinase (AMPK), which plays a vital role as an important energy sensor in cells. It is activated when cellular energy levels are low, such as during IF. A 2020 research study in Nature Reviews Endocrinology explains that activation of AMPK aids in suppressing gluconeogenesis and stimulates fatty acid oxidation, leading to optimal energy balance and reduction of visceral adipose tissue accumulation, a major contributor to insulin resistance and T2DM progression. AMPK is upregulated during fasting, which enhances glucose metabolism and reduces insulin resistance. This is imperative in managing T2DM, as it counters the effects of insulin resistance associated with T2DM.Exercise, which also promotes AMPK activation, complements IF and can promote a synergistic effect in improving insulin sensitivity and promoting fat burning, New Research Findings on IF and T2DM -The EARLY (Exploration of Treatment of Newly Diagnosed Overweight/Obese Type 2 Diabetes Mellitus) study is a randomized clinical trial published in JAMA Network Open (2024). Findings In this randomized clinical trial study found that a time-restricted eating window significantly improved fasting glucose levels and HbA1c levels in individuals with T2DM. The study examined the effect of a 16-week 5:2 meal replacement (5:2 MR) fasting plan that consisted of five days of normal eating and 2 days, nonconsecutive of restricted diet (500-600 calories). This group was examined alongside a group of patients who took metformin 0.5 g BID and empagliflozin 10 mg QD. The study wanted to investigate the changes in HbA1c in Chinese adults with early T2DM.-The study was a randomized clinical trial of 405 adults, and a study showed that the 5:2 MR approach led to better glycemic control at 16 weeks compared to the counter treatments with metformin and empagliflozin. The 5:2 MR group had the greatest reduction in HbA1c (-1.9%), followed by metformin (-1.6%), and empagliflozin (-1.5%). The 5:2 MR plan also revealed the greatest weight loss (-9.7 kg), followed by empagliflozin (-5.8 kg), and metformin (-5.5 kg). -This research suggests IF, such as 5:2 MR, can be a powerful tool in the management of T2DM and improving metabolic health. This study can potentially open doors for healthcare providers to provide the 5:2 MR approach for individuals as an effective initial lifestyle intervention. However, follow-up studies are needed to assess the effectiveness and durability of the 5:2 MR.Safety and Risks of IF in T2DM. -IF when combined with glucose-lowering medications (e.g., insulin, sulfonylureas, GLP-1 agonists) can increase the risk of hypoglycemia. Also, prolonged fasting can lead to nutrient deficiencies if not planned carefully. Patients should be counseled on maintaining a balanced, nutritious diet during non-fasting days. -IF is not suitable for everyone. Children under the age of 18 should not try IF due to needing proper calories for adequate development and proper growth. Also, it is recommended that pregnant or breastfeeding women do not undergo IF. It is advised that people with eating disorders should not try IF. -Individuals with certain medical conditions, such as kidney stones or gastroesophageal disease should speak with their doctor before trying IF. Also, patients on insulin or other glucose-lowering medications should adjust their dose and talk with their healthcare providers to prevent hypoglycemia during fasting. It is recommended that each person speak with their doctor to discuss the safety and risks of IF and see if it would benefit the individual before starting IF. -Many studies have explored the benefits of IF at the micro level revealing its cellular benefits and on a macro level of the body as a whole. However, more research is needed to confirm the long-term effects of IF on glycemic control and its sustainability as a therapeutic approach for T2DM. Conclusion:-IF shows potential for improving glycemic control, promoting weight loss, and enhancing metabolic health in individuals with T2DM. Despite its benefits, IF may present with risks, such as hypoglycemia, nutrition deficiencies, or dehydration in certain patients. Therefore, it may not be suitable for all individuals. It's important to monitor patients who engage in IF, especially for patients with T2DM. Patients should follow up with their doctor for individualized IF plans in patients with T2DM. ______________This week we thank Hector Arreaza and Cameron Carlisle. Audio editing by Adrianne Silva.Even without trying, every night you go to bed a little wiser. Thanks for listening to Rio Bravo qWeek Podcast. We want to hear from you, send us an email at RioBravoqWeek@clinicasierravista.org, or visit our website riobravofmrp.org/qweek. See you next week! _____________________References:Albosta, Michael, and Jesse Bakke. “Intermittent Fasting: Is There a Role in the Treatment of Diabetes? A Review of the Literature and Guide for Primary Care Physicians - Clinical Diabetes and Endocrinology.” BioMed Central, BioMed Central, 3 Feb. 2021, doi.org/10.1186/s40842-020-00116-1.Blumberg, Jack, et al. “Intermittent Fasting: Consider the Risks of Disordered Eating for Your Patient - Clinical Diabetes and Endocrinology.” BioMed Central, BioMed Central, 21 Oct. 2023, https://clindiabetesendo.biomedcentral.com/articles/10.1186/s40842-023-00152-7.De Cabo, Rafael, and Mark P. Mattson. “Effects of intermittent fasting on health, aging, and disease.” New England Journal of Medicine, vol. 381, no. 26, 26 Dec. 2019, pp. 2541–2551, https://doi.org/10.1056/nejmra1905136.Guo, Lixin, et al. “A 5:2 intermittent fasting meal replacement diet and glycemic control for adults with diabetes.” JAMA Network Open, vol. 7, no. 6, 21 June 2024, https://doi.org/10.1001/jamanetworkopen.2024.16786.Herz, Daniel, et al. “Efficacy of Fasting in Type 1 and Type 2 Diabetes Mellitus: A Narrative Review.” Nutrients, U.S. National Library of Medicine, 10 Aug. 2023, www.ncbi.nlm.nih.gov/pmc/articles/PMC10459496/. Herzig, S., & Shaw, R. J. (2018). AMPK: Guardian of metabolism and mitochondrial homeostasis. Nature Reviews Molecular Cell Biology, 19(2), 121-135.Longo, V. D., & Mattson, M. P. (2014). Fasting: Molecular mechanisms and clinical applications. Cell Metabolism, 19(2), 181-192. https://doi.org/10.1016/j.cmet.2013.12.008López-Jaramillo P, Gómez-Arbeláez D, López-López J, et al. The role of leptin/adiponectin ratio in metabolic syndrome and diabetes. Hormone Molecular Biology and Clinical Investigation. 2014;18(1):37–45.Mattson, Mark P., et al. “Impact of intermittent fasting on health and disease processes.” Ageing Research Reviews, vol. 39, Oct. 2017, pp. 46–58, https://doi.org/10.1016/j.arr.2016.10.005. Patikorn, Chanthawat, et al. “Intermittent fasting and obesity-related health outcomes.” JAMA Network Open, vol. 4, no. 12, 17 Dec. 2021, https://doi.org/10.1001/jamanetworkopen.2021.39558.Sharma, Suresh K, et al. “Effect of Intermittent Fasting on Glycaemic Control in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.” TouchREVIEWS in Endocrinology, U.S. National Library of Medicine, May 2023, www.ncbi.nlm.nih.gov/pmc/articles/PMC10258621/#:~:text=In%20IF%2C%20eating%20habits%20are,the%20risk%20of%20developing%20T2DM.Xiaoyu, Wen, et al. “The effects of different intermittent fasting regimens in people with type 2 diabetes: A network meta-analysis.” Frontiers in Nutrition, vol. 11, 25 Jan. 2024, https://doi.org/10.3389/fnut.2024.1325894. Theme song, Works All The Time by Dominik Schwarzer, YouTube ID: CUBDNERZU8HXUHBS, purchased from https://www.premiumbeat.com/.

In this powerful episode, Kelley sits down with Vince Pitstick, a trailblazer in functional and holistic health coaching. Vince's journey from personal trainer to pioneer in functional health has helped countless individuals reclaim their well-being, especially those struggling with hormonal imbalances and weight loss resistance.In this conversation, Vince dives deep into the complexities of women's hormones and how they intersect with metabolism, weight loss, and disease. If you've ever felt stuck in your health journey—whether due to unexplained weight gain, hormonal fluctuations, or resistance to traditional weight loss methods—this episode is for you.Vince shares his groundbreaking insights on root cause medicine and his innovative 4F Process, which is designed to restore balance and unlock your body's potential for optimal health. You'll also learn about the correlation between metabolic rate and disease, how to reverse weight loss resistance, and the debate surrounding GLP-1 agonists.Vince goes even deeper into why he believes all disease is rooted in metabolic dysfunction and how balancing hormones can unlock sustainable weight loss. His fresh perspective on aging and metabolism, plus a surprising approach to breaking through weight loss plateaus, will leave you feeling empowered and ready to take control of your health.This episode is packed with actionable insights and breakthrough strategies for anyone struggling with hormonal health or weight loss resistance. You don't want to miss it! Tune in to hear Vince's wisdom on how to transform your health from the inside out.What You'll Learn:How rare health conditions in childhood led Vince to functional healthThe fundamentals of root cause medicine and why it mattersThe link between women's hormones, weight loss, and metabolic healthSurprising trends in metabolic rate and their connection to diseaseHow to reverse weight loss resistance naturallyThe GLP-1 agonist debate and its implications for weight lossWhy adrenaline and stress could be fueling your weight gainA groundbreaking approach to hormonal health and long-term weight managementIf you're ready to break free from weight loss resistance and balance your hormones once and for all, this episode is your guide!

In this episode with repeat guest Joel Greene, you'll get to explore a unique dietary pattern inspired by nature's rhythms—foraging, fasting, and feasting. Joel introduces a powerful two-day cycle that mirrors ancient eating habits, alternating between foraging and an "amplified fast" to optimize body renewal. Along the way, you'll discover how this method boosts GLP-1 for appetite control and balances nutrient intake with smart food pairings. Plus, Joel shares tips on using pre-dinner shakes, resistant starches, and even cold plunges to enhance satiety, fitness, and overall health, while highlighting the crucial role of nitric oxide and a healthy microbiome. Joel is the creator of Veep Nutrition, the world's first commercially available program based on targeting gut communities to affect health and body composition. His system has been used by some of the nation's largest employers, including major cities and hospitals and featured on Dr. Phil Show storylines. He is the author of The Immunity Code: The New Paradigm for Real Health and Radical Anti-Aging. Joel has devoted over 50 years to the pursuit of health, nutrition and anti-aging. He was training with intervals in the 1970s, taking MCTs in the late '80s, following keto in the early '90s, and targeting AMPK by 2009. At age 55, he is a 100 percent natural athlete and uses no ergogenic aids while working out (on average once per week) and eats whatever whenever. Get ready for a rich and informative episode that rethinks modern dietary practices by embracing ancestral wisdom and cutting-edge science. Whether you're interested in diet hacks, longevity, or groundbreaking nutrition insights, you won't want to miss this episode! Full Show notes: https://bengreenfieldlife.com/immunitycode Episode Sponsors:  BioStack Labs: Visit Biostack.com/ben and save 19% when you buy a 3 month supply of NAD Regen! Aires Tech: Aires Tech is offering a 30% discount to all Ben Greenfield Life listeners at airestech.com/ben by using code BEN30. Organifi Shilajit Gummies: Get them now for 20% off at organifi.com/Ben. Vivobarefoot: You can purchase yours today with an exclusive 20% discount for my listeners by going to vivobarefoot.com/bengreenfield and using code BENG20. Pendulum: Get 20% off your first month of any Pendulum probiotic with code GREENFIELD at PendulumLife.com/Greenfield.See omnystudio.com/listener for privacy information.

Ozempic and Wegovy, otherwise known as Semaglutide, are still a hot topic for weight loss. But what if there was a natural way to increase GLP-1 and get its benefits without the side effects? On this episode of Vitality Radio, Jared explains what GLP-1 is and why it's so beneficial. He then shares the current research on many natural products showing significant benefits in this area and how he's going to utilize four specific supplements to work on his own GLP-1. You'll learn how these supplements work, why they may be a superior approach to the current pharmaceutical approach to using semaglutide, and how you can try them yourself.Products:Solaray Prosorb BerberineNatural Factors WellBetX BerberineTerry Naturally Red GinsengVital 5 Precision Probiotic Vital SporesVital Planet Vital Flora ProbioticsAdditional Information:#368: Ozempic, Wegovy, and Other Weight Loss Drugs - They're For Our Health Right?#227: VR Vintage: There is an Herbal Supplement that Works for Diabetes, Blood Pressure and Cholesterol Better than Drugs! Berberine is that Powerful!#394: Buyer Beware. Who Can You Trust With Your Supplement Dollars?#449: Suppressive Medicine: How Big Pharma and FDA Get It Wrong With StatinsVisit the podcast website here: VitalityRadio.comYou can follow @vitalityradio and @vitalitynutritionbountiful on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Please also join us on the Dearly Discarded Podcast with Jared St. Clair.Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.

What's the deal with statin drugs and “high cholesterol”? Even doctors are starting to raise questions. They say that “high cholesterol” is anything over 200 total, but where does this number come from? Is there evidence that cholesterol over 200 actually leads to heart disease? Why do we need cholesterol, and is it possible for it to get too low? On this episode of Vitality Radio Jared arms you with the information you need to decide what to do, if anything, about your “high” cholesterol.  Pharmaceutical companies often develop drugs that target specific symptoms by interfering with the body's natural processes. These medications can be effective in providing temporary relief from symptoms, but they don't usually address the underlying causes of a condition. This is called suppressive medicine, and such treatments may offer short-term benefits at the cost of long-term health. In this series of episodes on suppressive medicine, Jared aims to help you understand the ways in which these drugs work and what natural alternatives there are that work WITH your body's natural systems to address the root cause and rebalance the body. Products:BerberineAdditional Information:#332: Cholesterol Controversy - Jared's Interview on Inside The Aisle with Niki WolfeVisit the podcast website here: VitalityRadio.comYou can follow @vitalityradio and @vitalitynutritionbountiful on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Please also join us on the Dearly Discarded Podcast with Jared St. Clair.Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.

AMPK is said to serve as a “mitochondrial guardian.”

Amping AMP-activated protein kinase is one of the anti-aging pathways I cover in my longevity book, How Not to Age.