Podcasts about ampk

The 3 "Longevity Drugs" That Fail the Data, and 4 Repurposed Ones Worth Considering Back with another solo episode, this one on Big Pharma! Metformin, rapamycin, and statins are three of the most trusted names in longevity, and none of them hold up the way you've been told. This episode breaks down the human data behind the drugs everyone assumes are safe, and reveals four lesser-known repurposed pharmaceuticals that might do more for your metabolism, mitochondria, and lifespan. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Dave walks through why metformin blunts the muscle-building signal your body needs from exercise, why rapamycin's stunning mouse studies fell apart in the 2025 PEARL trial, and why statins help one person in a hundred while draining the CoQ10 your mitochondria depend on. Then he lays out the yes list: tadalafil for vascular and brain health, SGLT2 inhibitors for metabolic and kidney protection, acarbose for gut and longevity markers, and low dose naltrexone for calming an overactive immune system. Host Dave Asprey is the father of biohacking, founder of Danger Coffee and Smarter Not Harder, and a New York Times bestselling author who has spent decades studying human performance, functional medicine, and the science of not aging. As co-founder of Unlimited.Life, a concierge longevity practice that runs over $50,000 in lab work per client, he pulls back the curtain on what the data actually shows once you strip away the marketing. This is essential listening for anyone serious about biohacking, longevity, anti-aging, human performance, brain optimization, and hacking their own biology with real supplements and functional medicine tools instead of guesswork. You'll Learn: Why metformin can cancel out the muscle gains from resistance training and drain your B12 for years What the 2025 PEARL trial actually found when rapamycin was tested in healthy adults Why statins carry a 100-to-1 harm-to-benefit ratio and quietly starve your mitochondria of CoQ10 How tadalafil supports nitric oxide, vascular health, and neuroplasticity at low daily doses Why SGLT2 inhibitors trigger ketosis-like metabolic effects and protect kidney function How acarbose changes gut bacteria and shows some of the strongest longevity data in mouse studies How low dose naltrexone modulates the immune system and reduces neuroinflammation How to talk to your doctor about using these drugs off-label for longevity instead of disease treatment Thank you to our sponsors! - ALP | Go to alppouch.com, code DAVE for 10% off. - Timeline | Visit timeline.com/dave and get up to 20% off when you subscribe and save. - Kinetic | Instead of pushing your system harder, Kenetik feeds your brain the ketones it craves to fuel calm clarity and steady focus. Go to drinkkenetik.com/DAVE and use code DAVE for a discount. - Visit www.myvitalc.com/davesfav to unlock Dave's discount Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Metformin, Rapamycin, Statins, Tadalafil, Cialis, SGLT2 inhibitors, Jardiance, Acarbose, low dose naltrexone, longevity drugs, anti-aging medication, repurposed pharmaceuticals, off-label drugs, mTOR inhibitor, AMPK, autophagy, endothelial dysfunction, CoQ10, insulin resistance, mitochondrial efficiency, senescent cells, nitric oxide, neuroinflammation, vascular health, PEARL trial, Unlimited.Life Resources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15? • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 01:01 – Intro 03:48 – Metformin 09:18 – Rapamycin 12:55 – Statins 17:28 – Statins & CoQ10 19:38 – Tadalafil 23:43 – SGLT2 Inhibitors 26:12 – Acarbose 28:40 – Low-Dose Naltrexone (LDN) 31:44 – Dosing & Recap See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Full show notes: https://bengreenfieldlife.com/504 In this solosode, you'll get the latest research on three questions I keep getting asked. First, seed oils: a brand-new randomized controlled trial put 52 adults on either a low or a typical Western intake of linoleic acid for 12 weeks, and the results are important less for what they found than for what they didn't. You'll hear why arachidonic acid didn't move, why EPA dropped instead, what that does to your inflammatory balance, which seed oils I still think are worth avoiding, and the one dietary adjustment that matters most if seed oils are part of your diet. You'll also learn the surprisingly small amount of strength training that delivers the biggest longevity payoff, according to a 30-year study of more than 147,000 people, plus why pairing it with cardio is the single best exercise combination for blood pressure. I break down concurrent training, the interference effect between AMPK and mTOR, and when combining strength and cardio in one session helps you versus when it holds you back. Finally, I answer a listener question on peptides with six practical rules for stacking them safely, including which ones should never share a syringe, which ones cancel each other out at the receptor, and an honest look at how thin the human evidence really is behind the popular Wolverine stack. Episode Sponsors: Young Goose: Cutting-edge skincare that supports your skin's cellular health. Visit younggoose.com and use code BGF10 for 10% off. ULTRA: A clean, nicotine-free, caffeine-free pouch that delivers smooth, sustained energy and focus using clinically backed nootropics and adaptogens, without the jitters or crash. Visit takeultra.com and use code BENGREENFIELD for 15% off. ButcherBox: Premium, responsibly sourced protein delivered to your door, from 100% grass-fed beef to pasture-raised chicken and wild-caught seafood. New customers get a free protein for a year, plus $20 off the first box and free shipping, at ButcherBox.com/BEN. Larine: A better-for-you chewing gum that uses nano-hydroxyapatite, the same mineral your tooth enamel is made of, to support stronger teeth and fresher breath. Visit BuyLarine.com/BEN to get up to 50% off your order. Nuchido: Nuchido TIME+ is a science-backed supplement that optimizes your body's NAD metabolism across multiple pathways to support energy, cognition, recovery, and vitality. Visit BenGreenfieldLife.com/Nuchido and use code BEN20 to save 20%.See omnystudio.com/listener for privacy information.

Have you ever felt like you are doing everything right and your body is just not cooperating? You are eating well, exercising, tracking your protein, fasting, taking supplements, getting your steps in, and still gaining weight, feeling exhausted, sleeping poorly, and wondering why the strategies that used to work suddenly do not anymore. In this episode, I sit down with Debbie Potts to talk about what may actually be happening when healthy habits become unhealthy stressors. We get into the connection between the nervous system, metabolism, hormones, muscle, recovery, under-fueling, overtraining, and the chronic stress load so many women are carrying in midlife. We also talk about why more is not always better. Sometimes the answer is not another workout, another fast, another supplement, or another hormone adjustment. Sometimes the body needs a completely different signal. More safety. More fuel. More recovery. More muscle. Less chronic cardio. Less obsession. Less trying to force your body into submission. This is a conversation about learning how to read your body differently and understanding that your body may not be failing you at all. It may be adapting exactly the way it was designed to. In this episode, we cover: Why women can do everything "right" and still gain weight and feel exhausted What Debbie means by "metabolic chaos" How sympathetic dominance can affect energy, digestion, sleep, and recovery Why chronic fasting, low-carb diets, and excessive cardio can become stressors The difference between AMPK and mTOR and why midlife women need both Why under-eating can slow metabolism and make muscle gain harder How protein and strength training help support a stronger midlife metabolism Why low HRV can be a clue that your nervous system is under too much load The role of the vagus nerve in digestion, inflammation, and recovery Why hormones and peptides may help, but cannot replace foundational habits   Visit Debbie's website.     Sponsors Timeline is offering up to 39% off your first order of Mitopure. Gummies. Go to timeline.com/HORMONE use coupon HORMONE LMNT: Order your LMNT electrolytes today and get a FREE 8 pack of samples! Plus try it risk free, they have a no-questions-asked refund policy – you don't even have to send it back! Get 15% off Magnesium Breakthrough at bioptimizers.com/hormone     Are you in perimenopause or postmenopause and struggling with symptoms—but not getting the support you deserve? At Midlife Solutions, we specialize in hormone optimization for women in midlife. Our all-female clinical team offers telehealth care across all 50 U.S. states, with the ability to prescribe bioidentical estrogen, progesterone, testosterone, and thyroid medication.   Book your FREE Hormone Discovery Call Find out what's really driving your symptoms and what your next best steps are.   Visit the website: https://karenmartel.com   Shop the Midlife Solutions Store Over-the-counter bioidentical hormone creams and oils — no prescription needed. Including: • Progesterone • Estrogen Face Cream • Vaginal Moisturizer and more!   Take the Hormone Quiz Discover hidden hormone imbalances that could be driving your symptoms. Get personalized results (and yes, they may surprise you).   Women's Peptide Weight Loss Program Clinically guided, hormone-aware weight loss for midlife women.   Midlife RESET HRT Program A complete, supportive approach to hormone replacement therapy in midlife.   Your host: Karen Martel Certified Hormone Specialist, Transformational Nutrition Coach, & Weight Loss Expert   Karen's Facebook Karen's Instagram

Dr. Dwayne Jackson is a health specialist, medical educator, scientist, and entrepreneur with a PhD in neurovascular physiology. Mitochondrial peptides may be promising, but they cannot replace the aerobic base that makes their effects measurable. Dr. Dwayne Jackson explains AMPK and mitochondrial signaling, what MOTS-c and SS-31 can and cannot tell us, and why fitness data, training, and recovery come before any experimental compound. Expect to learn how aerobic fitness supports strength and Strongman training, why lactate clearance and conditioning can become the rate limiter, what AMPK and mTOR signal, how kidney disease changed Dwayne's perspective on aerobic capacity, where the evidence for MOTS-c and SS-31 is limited, how to design a more useful N-of-1 experiment, and why training, nutrition, recovery, COAs, and third-party testing come before experimental compounds. Connect with Dwayne: Website: drdwaynejackson.com Google Scholar Episodes you'll enjoy next: #396 — Are Your Peptides Illegal? — Rick Collins: A practical look at peptide science, regulation, and the gray market. #393 — From Powerlifter to Trail Runner — Paul Oneid & Cody Miller: VO2 max, cardiac adaptations, and the transition from strength sports to endurance. Episode Timestamps: 01:53 — Mitochondrial peptides and the aerobic-training foundation 03:19 — Peptides as training amplifiers, not replacements 04:22 — AMPK, mTOR and mitochondrial signaling 05:50 — Why aerobic fitness supports strength and Strongman training 08:12 — Conditioning, lactate clearance and the rate limiter for strength athletes 10:58 — Wingate tests and overlapping energy systems 15:12 — Kidney disease, mitochondrial dysfunction and aerobic collapse 21:22 — Hypertensive crisis, dialysis and recognizing a major fitness decline 24:48 — Kidney transplant recovery and rebuilding aerobic capacity 28:27 — The evidence and limitations behind mitochondrial peptides 34:55 — MOTS-c, AMPK activation and anecdotal HIIT performance 39:59 — SS-31, cardiolipin and mitochondrial efficiency 48:32 — Why training, nutrition and recovery come before peptides 58:40 — Using performance data to make an N-of-1 experiment more useful 1:01:22 — SS-31 before training, AMPK timing and recovery trade-offs 1:06:07 — SLU-PP-332, exercise mimetics and the gap in human data 1:09:17 — Peptide sourcing, COAs and third-party testing 1:12:02 — Genetics, response variability and sustainable performance Get the Daily Fitness Insider newsletter (free): https://www.miketnelson.com/newsletter

What if your metabolism isn't broken—but responding to the signals it's receiving? Welcome to The FutureYou Blueprint™ PNOĒ Metabolic Patterns™ Series, where Debbie Potts explores the five common metabolic patterns identified through advanced PNOĒ Metabolism Testing. In each episode, you'll discover how stress, nutrition, muscle health, hormones, blood sugar, digestion, sleep, recovery, and lifestyle all influence how your body produces and uses energy. Learn why two people can follow the same diet or exercise plan and experience completely different results—and why identifying your unique metabolic pattern is the foundation of a personalized strategy for improving metabolism, performance, healthy aging, and longevity. Whether you're an athlete, health enthusiast, or practitioner, this educational series will help you better understand the science of metabolism and the power of personalized metabolic testing. Ready to discover your metabolic pattern?

A partir de los 40, el cuerpo de la mujer experimenta un cambio profundo que va más allá de la edad cronológica. En este video, exploramos por qué muchas mujeres comienzan a ganar grasa abdominal, pierden sensibilidad metabólica y sienten que su energía se agota, incluso haciendo lo mismo de siempre.Analizamos el papel de la Berberina como un aliado estratégico, no como un atajo milagroso, sino como un activador de la vía AMPK.Lo que acabas de ver es solo el principio. Tienes todos los detalles en el vídeo completo. ¡Suscríbete para no perderte nada de lo que viene!Más contenido del Dr. HernándezInstagram: https://www.instagram.com/dr.ahernandezFacebook: https://www.facebook.com/doctorantoniohernandezMi marca de suplementos: https://belevels.com/drhernandez⚡️Utiliza el código DRHERNANDEZ para obtener un descuento en todos los productos.TikTok: https://www.tiktok.com/@dr.ahernandezLinkedIn: https://www.linkedin.com/in/doctor-antonio-hernandez/Website: https://www.doctorantoniohernandez.esNewsletter: https://manage.kmail-lists.com/subscriptions/subscribe?a=TrMmZT&g=XwDQwzMi equipo clínico: https://www.instagram.com/clinicakeval/

USC Gerontology Professor Dr. Changhan David Lee breaks down the discovery of MOTS-c, a novel mitochondrial-derived peptide that functions as an exercise mimetic, cellular stress responder, and immunomodulator.Are mitochondria more than just cellular powerhouses? In this episode of Modern Healthspan, Dr David Lee, Associate Professor at the USC Leonard Davis School of Gerontology and co-discoverer of MOTS-c, joins us for a deep dive into the emerging world of mitochondrial-derived peptides (MDPs). Dr. Lee explains how these small microproteins, encoded within the mitochondrial 12S rRNA locus, act as critical retrograde signaling molecules. We explore how MOTS-c translocates to the nucleus during metabolic stress, coordinates with AMPK and hypothalamic POMC neurons, and functions as an interferon-responsive host defense peptide. Additionally, Dr. Lee shares findings from preclinical models examining sarcopenia, muscle homeostasis, and age-related physical capacity, while providing an update on the current regulatory state, WADA anti-doping classification, and human translational pipeline of MDP research.

Should endurance athletes complete high-intensity intervals while fresh, or place them later in a workout after accumulating fatigue? Paul Warloski and Dr. Paul Laursen explain why the answer depends on the type of fatigue involved. General systemic or neuromuscular fatigue may be a reason to postpone intensity, while lower muscle-glycogen availability can amplify signals associated with mitochondrial development and fatigue resistance. The discussion covers AMPK, fat oxidation, fast-twitch muscle fibers, running mechanics, heat, race specificity, athlete type, training experience, and why experienced athletes may benefit from occasionally performing intervals later in a session—even when their power output is lower.Key takeawaysNot all fatigue is the same. Suppressed HRV, neuromuscular fatigue, and feeling systemically depleted are different from deliberately training with reduced glycogen availability.Do not force intensity when genuinely under-recovered. When the central nervous system appears flat or muscle tone and coordination are impaired, recovery or easy aerobic work may be more appropriate.Lower glycogen can increase the adaptive signal. The episode explains that training with reduced glycogen may amplify AMPK signaling, encouraging mitochondrial development.Lower power does not necessarily mean a poor session. Intervals performed later in a workout may produce less power while still creating a strong physiological stimulus.The aerobic system supports repeatable power. Training fast-twitch fibers under depleted conditions may help those fibers become more fatigue-resistant while retaining their strength.Running requires greater caution than cycling. Fatigue can alter stride length, ground-contact time, stiffness, and movement patterns, potentially increasing injury risk.Experienced athletes are better candidates for fatigue-state intervals. Beginners should generally complete a manageable warm-up and perform their intervals with good form and quality.Athlete profile matters. “Twitchy” athletes may require more recovery than diesel-type athletes, both between intervals and between demanding training days.Heat adds another stressor. High temperatures may increase glycogen use and reduce the ability to sustain interval quality, so heat-based sessions require careful control.Use fatigue-state intervals selectively. They are a tool for building durability, not a requirement for every high-intensity workout.TRY ATHLETICA.AI | Adaptive Endurance Training Plans Powered by Sports ScienceAthlete Profiling PrimerDr. Paul LaursenPaul Warloski - Simple Endurance Coaching

Your liver and blood sugar are far more connected than most people realize. In this episode, Nurse Doza walks through five links between the two: how the liver stores and releases glucose, where insulin resistance actually begins, how stress and cortisol raise blood sugar without food, how all of it lands on your mitochondria, and what obesity has to do with the whole picture. Featured Product  The Metabolic Pack bundles the three formulas this episode keeps circling back to: Liver Boost to support phase I and phase II liver detoxification pathways, Mitochondriac for resveratrol, quercetin and pterostilbene to support cellular energy production, and Zen to support a healthy stress and cortisol response. Liver, cellular energy, and stress — supported together in one simple daily protocol. Suggested use: 2 Liver Boost, 1 Mitochondriac, and 1 Zen daily with food.

What if your metabolism isn't broken—but responding exactly as your body has been programmed to survive? Welcome to The FutureYou Blueprint™ PNOĒ Metabolic Patterns™ Series, where Debbie Potts explores the five common metabolic patterns revealed through advanced PNOĒ breath analysis. In each episode, you'll learn how stress, nutrition, muscle health, hormones, blood sugar, digestion, sleep, recovery, and lifestyle influence the way your body produces and uses energy. Discover why two people can follow the same diet or exercise plan and experience completely different results—and why identifying your unique metabolic pattern is the first step toward creating a personalized strategy for better health, performance, and longevity. This educational series is designed to help you better understand your metabolism and introduce you to the science behind Debbie's personalized approach through The FutureYou Blueprint™. Learn more or schedule your PNOĒ Metabolism Test:

Send us Fan MailMitochondrial peptide MOTS-c is a stress-induced signal that reprograms cell metabolism.TOPICS DISCUSSED:Mitochondrial Roles: Not just ATP production, but “speaker of the house” via communication molecules that “talk” to the rest of the cell.Origin of Communication: Mitochondrial peptides were likely co-opted from ancient antimicrobial factors to synchronize nuclear and mitochondrial genomes.MOTC Discovery: Identified in mitochondrial ribosomal RNA regions linked to interferon responses.Stress Induction: MOTS-c is produced in response to exercise, immune activation, and nutrient withdrawal; circulates as a mitokine.Nuclear Regulation: MOTS-c translocates to the nucleus under stress and acts as a nonspecific cofactor that shapes chromatin accessibility and gene expression.Metabolic Effects: Prevents diet-induced obesity and fatty liver in mice without altering baseline weight; engages AMPK and suppresses anabolic pathways.Immune Modulation: Shifts immune cell programs to reduce autoimmune attack in type 1 diabetes models.Aging Phenotypes: Daily or intermittent dosing doubles running capacity and preserves walking ability in old mice.ABOUT THE GUEST: Changhan David Lee, PhD is Associate Professor at the University of Southern California Leonard Davis School of Gerontology. His laboratory investigates mitochondrial communication and microproteins in the biology of aging. RELATED CONTENT:Article | MOTS-c & Cellular Energy HomeostasisSupport the showSupport my work:Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.For all the ways you can support my efforts.

Alle Informationen zur Carnivoren Ernährung unter www.carnitarier.de.  ______________________________________________  Herzlichen Dank an unsere WERBEPARTNER:  www.carnivoro.eu: Supplemente rund um die Carnivore Ernährung Mit dem Gutscheincode CARNITARIER erhältst du 10 % Rabatt auf deinen ersten Einkauf! Affiliate Link: www.carnivoro.eu/carnitarierin www.kreutzers.eu: Die größte Auswahl an Online verfügbarem frischem Fleisch. Mit dem Gutscheincode CARNITARIER erhältst du 10 % Ermäßigung.   www.mindful-meat.com: Hochwertiges Hirschfleisch aus den Wäldern Deutschlands. Mit dem Gutscheincode CARNITARIER erhältst du 10 € Ermäßigung auf deinen Einkauf.  www.pemmican-shop.de: Europas einzige originale Survival Beef Bar – Made in Germany. Mit dem Gutscheincode CARNITARIER erhältst du 10 % Ermäßigung auf deinen ersten Einkauf. _____________________________________________ Julia Tulipan über Ketone als Signalmoleküle - mehr als nur Energie Julia Tulipan ist Biologin (Mag.) und Master of Science in klinischer Ernährungsmedizin, Speakerin, Dozentin und Bestseller-Autorin ("Keto Kompass"). Sie schreibt für verschiedene Magazine sowie auf ihrem eigenen Blog JuliaTulipan.com vor allem zu ketogener und artgerechter Ernährung sowie Bewegung. Auf dem Carnivore Convent 2026 hielt sie den Vortrag "Ketone als Signalmoleküle – Mehr als Energie", den wir in dieser Folge zusammenfassen. Ketonkörper – Beta-Hydroxybutyrat, Acetoacetat und Aceton – entstehen in der Leber aus Fettsäuren bei Fasten, intensivem Training oder kohlenhydratarmer Kost und galten lange nur als Notfall-Brennstoff fürs Gehirn. Tulipan zeigt, dass sie weit mehr sind: wasserlösliche Botenstoffe, die direkt in den Energiestoffwechsel eingreifen, mTOR und AMPK modulieren, das entzündungstreibende NLRP3-Inflammasom hemmen und als körpereigene HDAC-Inhibitoren sogar die Genexpression beeinflussen. Der Vortrag spannt den Bogen von der 100-jährigen Geschichte der ketogenen Ernährung in der Epilepsiebehandlung bis zur aktuellen Forschung zu Diabetes, Krebs, Alzheimer und psychiatrischen Erkrankungen – Stichwort "Metabolic Psychiatry" mit Studien zu Depression, Angst, Schizophrenie und Essstörungen. Eine aktuelle RCT-Studie (Hengist et al. 2024) belegt zudem messbare Vorteile gegenüber reiner Zuckerreduktion bei Gewicht, Hormonen wie GLP-1 und dem Darmmikrobiom. Tulipan ordnet auch kritisch ein, warum manche Schlagzeilen ein negativeres Bild zeichnen, als die Studienlage hergibt. Ihr Fazit: Ketogene Ernährung sollte als ernstzunehmende Stoffwechseltherapie einen festen Platz in der klinischen Praxis bekommen. Eine spannende Grundlage für alle, die verstehen wollen, warum Ketose weit mehr ist als nur eine Diät zum Abnehmen. ________________________________ Fleischzeit ist der erste deutschsprachige Podcast rund um die carnivore Ernährung. Hier erfahrt ihr Tipps zur Umsetzung des carnivoren Lifestyles, wissenschaftliche Hintergründe zur Heilsamkeit sowie ökologische und ethische Informationen zum Fleischkonsum. Eine Übersicht über alle Folgen findet ihr hier: www.carnitarier.de/fleischzeitpodcast Andrea Siemoneit berichtet nach über sechs Jahren carnivorer Ernährung über ihre Erfahrungen und Erkenntnisse. Außerdem interviewt sie andere Carnivoren und Wissenschaftler. Ihr findet sie auf Instagram unter @carnitarier.de Handbuch der Carnivoren Ernährung: www.carnitarier.eu Haftungsausschluss:Alle Inhalte im Podcast werden von uns mit größter Sorgfalt recherchiert und publiziert. Dennoch übernehmen wir keine Haftung für die Richtigkeit, Vollständigkeit oder Aktualität der Informationen. Sie stellen unsere persönliche subjektive Meinung dar und ersetzen auch keine medizinische Diagnose oder ärztliche Beratung. Dasselbe gilt für unsere Gäste. Konsultieren Sie bei Fragen oder Beschwerden immer Ihren behandelnden Arzt.

In this video, I explain what AMPK is and its central role in metabolism and aging. Discover how AMPK activation can lead to significant fat loss and improved metabolic function. We also explore the extensive AMPK benefits, including enhanced cellular respiration and reduced oxidative stress, offering valuable longevity tips.CHAPTERS00:00 Why ATX-304 Matters for Energy & Longevity00:48 What AMPK Is and Why It Controls Metabolism01:48 What ATX-304 Actually Does02:58 The Potential Health Benefits04:24 ATX-304 vs PQQ and CoQ1005:18 Safety, Dosing, and What We Don't Know06:13 Final Thoughts on ATX-304Connect with Dr. Greg JonesGet 10% off your first order at Dr. Jones Supplement Store when you join the email list. https://drjonessupplements.com/Instagram: @doctorjones_doctorjones Enovative Wellness Center: https://enovativewellness.com/

„Kaum ein Pflanzenstoff wird derzeit so intensiv erforscht wie Berberin. Der Grund dafür liegt tief im Energiestoffwechsel unserer Zellen.“ Jede einzelne Zelle unseres Körpers muss permanent entscheiden, ob sie Energie speichert, verbraucht oder neu bereitstellt. Gesteuert wird dieser Prozess unter anderem durch AMPK, einen der wichtigsten Energiesensoren unseres Stoffwechsels. Genau hier setzt Berberin an. Der natürliche Pflanzenstoff wird seit Jahrhunderten in der traditionellen Medizin eingesetzt und steht heute im Fokus der Forschung, weil er Stoffwechselprozesse beeinflussen könnte, die für Blutzucker, Fettstoffwechsel und Insulinsensitivität entscheidend sind. In dieser Deep Dive Folge der artgerecht HEALTH NERDS erklären Podcast-Host Felix Moese und Gesundheitswissenschaftler Matthias Baum, was Berberin genau ist, wie es auf zellulärer Ebene wirkt und warum der Vergleich mit Abnehmmedikamenten wie Ozempic wissenschaftlich zu kurz greift. Im Mittelpunkt stehen die Aktivierung des Enzyms AMPK, die Regulation des Glukosestoffwechsels sowie die Frage, welche Effekte auf Prädiabetes, Typ 2 Diabetes und Fettstoffwechsel heute tatsächlich durch Studien gestützt werden und wo die Evidenz noch begrenzt ist. Außerdem geht es um die geringe Bioverfügbarkeit von Berberin, mögliche Einsatzgebiete bei Insulinresistenz und metabolischem Syndrom sowie um aktuelle Forschung zu Darmmikrobiom, Fettleber und Healthy Aging. Denn immer deutlicher zeigt sich: Hinter Themen wie Blutzucker, Gewichtsregulation oder Cholesterin stehen keine isolierten Prozesse, sondern Milliarden von Zellen, die ihren Energiehaushalt permanent neu organisieren. Genau dieses biologische Zusammenspiel besser zu verstehen, ist der Schlüssel zu einem besseren Verständnis unseres Stoffwechsels. HEALTH NERDS. Mensch, einfach erklärt. Spare 15% auf Deine erste Bestellung auf https://artgerecht.com mit dem Code: HEALTHNERDS15 (im Warenkorb eingeben) Ein ALL EARS ON YOU Original Podcast.

This episode is for ambitious, health-driven people who want to optimize their body from the inside out  and it makes the case that the most radical thing you can do for your brain, mood, and longevity isn't another nootropic or longevity supplement: it's fixing your gut. The science applies to anyone, but the framing throughout is high performers who feel "off" despite doing everything right.Did you know that over 90% of your serotonin, much of your dopamine and GABA, and the BDNF that builds your neurons are stimulated in your gut  and that a broken gut is, quite literally, a broken brain? In this episode, Andres sits down in person with Nathaly Marcus clinical nutritionist, functional-medicine pioneer, founder of the Bienesta functional medicine center, and author of Sano, salvaje y sabio (Healthy, Wild, and Wise)  for a deep, practical masterclass on the gut microbiome, postbiotics, and the nervous system underneath it all.Drawing on her own journey from three-and-a-half years of post-surgical pain, burnout, and "never enough" perfectionism to a philosophy of self-love, rituals over habits, and healing from gentleness instead of fear, Nathaly breaks down the 5 R's of functional medicine (starting with remove), why Akkermansia and butyrate are the quiet heroes of gut repair, and how postbiotics act as the "tools" your microbiome builds to talk to your brain, mitochondria, and hormones. She and Andres go deep on leaky gut and autoimmunity, SIBO and stress, the histamine surge more and more people are experiencing, and the longevity pathways FOXO, Klotho, Nrf2  you can switch on through epinutrients and smart discomfort.Key Topics Discussed:A Broken Gut Is a Broken Brain: Why the gut is the most important "agent of wisdom" in the body, and how inflammation there shows up as brain fog, anxiety, and low mood.Postbiotics Explained: The artisan-and-tools (and garden) metaphor why postbiotics, not just probiotics, are the molecules that rebuild your gut lining, mitochondria, and brain.Akkermansia & Butyrate: How this keystone bacteria feeds on mucin and polyphenols, why fasting lets the strongest species survive, and how butyrate lowers inflammation and lifts depression.Leaky Gut & Autoimmunity: The zonulin story, what a GI Map reveals (IgA, calprotectin, gluten antibodies), and why Nathaly argues most autoimmune disease Hashimoto's, lupus, psoriasis, even Parkinson's  begins in the gut.SIBO, Stress & Digestion: How survival mode lowers betaine and stomach acid, feeds bacterial overgrowth, and wrecks absorption  and why probiotics can sometimes make it worse.Histamine Intolerance: Why so many people are suddenly reacting to coffee, leftovers, and sulfur-rich foods, the role of the DAO enzyme, and the SIBO and food-diversity roots underneath it.Food Diversity Over Repetition: Why "marrying" one food every day drives sensitivities and inflammation, and how rotating protein, produce, and ferments restores biodiversity.Fiber as the Forgotten Pillar: Why half your plate should be fiber, how to build to ~30g a day without bloating, and the inulin, pectin, resistant starch, and green-juice tactics to get there.Longevity Pathways You Can Switch On: FOXO, Klotho, Nrf2, AMPK and sirtuins  and the epinutrients (rhodiola, curcumin, cacao, astaxanthin, sulforaphane, omega-3, PC) plus hormesis that activate them.Nervous System, Trauma & "I Am Enough": Why "I am safe and I am secure" is the foundational mantra, why motivation from fear leads to self-sabotage, and how rituals done from love not guilt become longevity.Actionable Tips:Start Your Day for Your Gut: Warm water with lemon and a little apple cider vinegar to stimulate digestive fire, then chia, flax, and a splash of olive oil to feed the gut lining a cleaner, lead-free alternative to psyllium.Rebuild Before You Add: Remove first (foods, toxins, disruptors, and toxic relationships), repair with glutamine, butyrate, and aloe, then reintroduce ferments slowly a "tequila shot" of rotating kefir, not a jar of sauerkraut.Feed Your Postbiotics: Prioritize polyphenols and prebiotics pomegranate, red/purple pigments, artichoke, asparagus, leek, onions, olive oil, and green tea to stimulate Akkermansia and butyrate.Make a Rotating Green Juice: Greens plus a detox herb (cilantro/coriander, parsley) and a daily-rotated polyphenol powder (pomegranate, maqui, açai) instead of overpriced all-in-one greens powders.Eat for Diversity, Not Efficiency: Rotate proteins, produce, seeds, and ferments through the week even "healthy" foods repeated daily can drive sensitivities and inflammation.Mind the State You Eat In: Be present, chew thoroughly, don't drink water with meals (sip between them), and drop into rest-and-digest first because how you eat changes how your body absorbs it.Do Hard Things on Purpose: Use temporary, intelligent discomfort sauna, cold, fasting, hard training to switch on FOXO, Klotho, Nrf2 and build a body that adapts to stress instead of breaking under it.Test, Don't Guess: Get a GI Map and food-sensitivity testing before assuming the problem is willpower or mindset find your personal bottlenecks first. 

Links, cheatsheet, private group and more: ⁠https://hunterwilliamshealth.com/linksIn this masterclass I break down what MOTS-c actually is. It's a tiny peptide your mitochondria make when you exercise. It's the only major peptide coded inside the mitochondrial genome, not the cell nucleus.I get into how it flips the AMPK switch, your cell's main fuel gauge. I cover the dual action that lets it travel into the nucleus and turn on antioxidant genes. That part makes it pretty unique.Then I walk through the practical stuff. Who's a good candidate and who should skip it. My full dosing tiers, from a 250mcg screening dose up to 5mg. Cycling, reconstitution, and how I pair it with SS-31 and humanin.I also cover the side effect nobody warns you about. Around 10% of people react badly, and some of those reactions are serious. That's why I start low and work up slowly.A heads up on the evidence. Most of the exciting data is still animal models. Human data is thin, so I flag where I'm extrapolating.MOTS-c is more bioactive than its reputation suggests. Treat it with respect and it rewards you.

Episode Description: Everyone is calling it nature's Ozempic. That is marketing. And it is doing a total disservice to what berberine actually does. Berberine is not a GLP-1 drug. It does not work the same way. The weight loss outcomes are not comparable. And if you are taking it expecting to drop 15% of your body weight, you are going to be disappointed. But here is what the research actually shows, and why Dr. G takes berberine every single day. The clinical evidence on berberine for blood sugar, cholesterol, insulin resistance, and gut health is genuinely compelling. A three month randomized controlled trial in newly diagnosed type two diabetics showed reductions in HbA1c, fasting blood glucose, and post-meal blood glucose that were comparable to metformin. A 2022 meta analysis confirmed it hits triglycerides, total cholesterol, LDL, blood pressure, and insulin resistance markers simultaneously. And the gut microbiome research is a piece almost nobody is talking about.In this episode, you will learn:  •  What berberine actually does in the body through the AMPK pathway, why it is not a GLP-1, and what to realistically expect from it  • Why standard berberine has a major absorption problem, what dihydroberberine is and why it may deliver 2 to 4 times more into circulation at a fraction of the dose  • Exactly how to buy berberine intelligently, what standardization means on a label, which forms to choose, and what to avoid Dr. G's recommended berberine brands linked in the show notes.Product reviews assess both brand transparency and product quality. If a company doesn't respond to our outreach, it doesn't automatically mean their product is low quality but it does mean they're failing their customers on transparency and communication. We reach out multiple times. No response isn't an oversight, it's a choice. And consumers deserve better. Timestamps: 0:00 - Intro 1:44 - How Berberine Works in the Body (And Why It's Not a GLP-1 Drug) 3:24 - The Weight Loss Reality: What Berberine Can and Can't Do 4:48 - Blood Sugar and Insulin Resistance: Where the Evidence Is Strongest 6:30 - Comparable to Metformin in Some Trials — What That Actually Means 7:42 - Cholesterol, Triglycerides & Cardiovascular Risk: Berberine's Strongest Evidence Base 9:44 - How Dr. G Uses Berberine in His Own Daily Routine 10:38 - Berberine's Underrated Effect on the Gut Microbiome 12:30 - The Big Absorption Problem With Standard Berberine (And the Solution) 14:22 - Dihydroberberine: 2-4x More Bioavailable in Human Trials 15:18 - How to Buy Berberine Intelligently: Standardization, Form & Third-Party Testing 17:00 - Who Should Take Berberine (And Who Shouldn't) Learn more about your ad choices. Visit megaphone.fm/adchoices

Are light runs (Zone 2 runs) better than heavier workouts? Sophie goes on a semi-manic tangent in her most enthusiastic episode yet to answer whether less intense exercise might actually help your fitness level, aerobic threshold and mitochondrial efficiency. Also, Chris tells a funny marathon story and a viewer question tries to fact-check to the fact checkers on whether walking and running burn the same amount of energy.   Become a supporter of our show today either on Patreon or through PayPal! Thank you! http://www.patreon.com/thebodyofevidence/ https://www.paypal.com/donate?hosted_button_id=9QZET78JZWCZE   Email us your questions at thebodyofevidence@gmail.com.   Hosts:     Christopher Labos & Sophie Tseng Pellar Editor:    Robyn Flynn Researcher: Auriane Journet Theme music: “Fall of the Ocean Queen“ by Joseph Hackl Rod of Asclepius designed by Kamil J. Przybos Chris' book, Does Coffee Cause Cancer?: https://ecwpress.com/products/does-coffee-cause-cancer   Obviously, Chris is not your doctor (probably). This podcast is not medical advice for you; it is what we call information. References: 1.   Storoschuk, K. L., Moran-MacDonald, A., Gibala, M. J., & Gurd, B. J. (2025). Much Ado About Zone 2: A Narrative Review Assessing the Efficacy of Zone 2 Training for Improving Mitochondrial Capacity and Cardiorespiratory Fitness in the General Population: KL Storoschuk et al. Sports Medicine, 55(7), 1611-1624.  2.   Mølmen, K. S., Almquist, N. W., & Skattebo, Ø. (2025). Effects of exercise training on mitochondrial and capillary growth in human skeletal muscle: a systematic review and meta-regression. Sports Medicine, 55(1), 115-144. 3.   Inglis, E. C., Iannetta, D., Rasica, L., Mackie, M. Z., Keir, D. A., Macinnis, M. J., & Murias, J. M. (2024). Heavy-, severe-, and extreme-, but not moderate-intensity exercise increase V̇o 2max and thresholds after 6 wk of training. Medicine & Science in Sports & Exercise, 56(7), 1307-1316. 4.   McConell, G.K., Wadley, G.D., Le plastrier, K. and Linden, K.C. (2020), Skeletal muscle AMPK is not activated during 2 h of moderate intensity exercise at ∼65% in endurance trained men. J Physiol, 598: 3859-3870. https://doi.org/10.1113/JP277619 5.   Meixner, B., Filipas, L., Holmberg, H. C., & Sperlich, B. (2025). Zone 2 Intensity: A Critical Comparison of Individual Variability in Different Submaximal Exercise Intensity Boundaries. Translational sports medicine, 2025, 2008291. https://doi.org/10.1155/tsm2/2008291 6.   Harber MP, et al. Impact of Cardiorespiratory Fitness on All-Cause and Disease-Specific Mortality: Advances Since 2009. Progress in Cardiovascular Diseases 2017;60(1):11-20. PubMed 28286137 7.   Kodama S, Saito K, Tanaka S, et al. Cardiorespiratory Fitness as a Quantitative Predictor of All-Cause Mortality and Cardiovascular Events in Healthy Men and Women: A Meta-analysis. JAMA 2009;301(19):2024-2035. PubMed 19454641  

The anti-aging industry is a $59 billion business built on creams, serums, injections, IV drips, and stem cell tourism, and almost all of it is being sold from the outside in, as the actual aging is happening at the level of your DNA, your mitochondria, and the cellular pathways that decide whether your cells protect themselves or wear themselves down over time. Inside today's episode, I walk through the 80/20 breakdown on longevity that most people aren't getting, starting with the identical twin research showing aging is roughly 20% genetic and 80% lifestyle, and the shift in the field from the oxidative stress theory to the current information theory of aging.Topics discussed: - Genetics vs Lifestyle in Aging- The Nine Hallmarks of Aging- The Information Theory of Aging- Sirtuins, AMPK, and mTOR- The Rhythm Between Growth and Repair- Chronological vs Biological Age- Methylation Clocks and Telomere Length- Nutrition, Fasting, and Training Interventions- Sleep, Stress, and Community---------- ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠My Live Program for Coaches: The Functional Nutrition and Metabolism Specialization ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.metabolismschool.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠---------- [Free] Metabolism School 101: The Video Series⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠http://www.metabolismschool.com/metabolism-101⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠----------Subscribe to My Youtube Channel: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://youtube.com/@sammillerscience?si=s1jcR6Im4GDHbw_1⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠----------⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Grab a Copy of My New Book - Metabolism Made Simple⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠---------- Stay Connected: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Instagram: @sammillerscience⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Youtube: SamMillerScience⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Facebook: The Nutrition Coaching Collaborative Community⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠TikTok: @sammillerscience⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠----------“This Podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast and the show notes or the reliance on the information provided is to be done at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment and is for educational purposes only. Always consult your physician before beginning any exercise program and users should not disregard, or delay in obtaining, medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions. By accessing this Podcast, the listener acknowledges that the entire contents and design of this Podcast, are the property of Oracle Athletic Science LLC, or used by Oracle Athletic Science LLC with permission, and are protected under U.S. and international copyright and trademark laws. Except as otherwise provided herein, users of this Podcast may save and use information contained in the Podcast only for personal or other non-commercial, educational purposes. No other use, including, without limitation, reproduction, retransmission or editing, of this Podcast may be made without the prior written permission of Oracle Athletic Science LLC, which may be requested by contacting the Oracle Athletic Science LLC by email at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠operations⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@sammillerscience.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. By accessing this Podcast, the listener acknowledges that Oracle Athletic Science LLC makes no warranty, guarantee, or representation as to the accuracy or sufficiency of the information featured in this Podcast."

Hosts: Ed Jones (Owner – Nutrition World) & Clint Powell A variety of topics all related to living a healthy life Presented by: Nutrition World www.nutritionw.com Broadcasting from the Nooga Dentistry Studio www.noogadentistry.com Production of: Whitfield Media Group www.vitalhealthradio.com Title: Peptides, AMPK, and Other Supplements for Weight Loss.  [0:00:00] Headlines, Glucosamine & Alzheimer's, and Study Skepticism Ed recaps last week's episode about truly high-quality eggs and how to tell if eggs are nutritious Mentions Kristy (“chicken whisperer”) and that her eggs are sold at Nutrition World. Ed addresses a national headline claiming glucosamine may accelerate Alzheimer's. Explains it was an observational study based on medical records, not a controlled trial. People who start glucosamine often already have joint pain, inflammation, or cognitive decline. This creates confounding factors (correlation ≠ causation). Even broad AI-style review of research finds little credibility for the idea that glucosamine worsens Alzheimer's and notes that some data suggest potential benefit. Clint and Ed discuss: How people often change multiple habits at once when they get sick (diet, supplements, etc.). The importance of baseline data (bloodwork, journaling) before judging if changes work [0:13:29] Guest Elisha: What Peptides Are & How They Can Assist Weight Loss Elisha from Nutrition World is introduced. Ed recounts his history with weight-loss supplements: Heavy use of ephedra in the '80s and '90s: effective but with side effects (nervousness, blood pressure, insomnia). Ephedra was eventually banned; Ed largely stopped promoting weight-loss pills, focusing instead on lifestyle, macros, and exercise. Ed admits he dismissed Ancient Nutrition's new Active Peptides at first, assuming it was a label trend riding on the buzzword “peptides.” Reports strong positive feedback from real customers, including many who are not heavy supplement users but want help with appetite and weight. Elisha  explains peptides with a “pearl necklace” analogy: A full necklace = protein. Individual pearls = amino acids. Small segments of the chain = peptides, which act like signals or “text messages” in the body. Distinguishes nutritional peptides (like in this product) from therapeutic/medical peptides (e.g., GLP‑1 drugs). Describes DNF‑10, the peptide in Active Peptides: A three‑amino‑acid chain isolated from baker's yeast (Saccharomyces cerevisiae). Modulates appetite‑related hormones: Ghrelin (“hunger hormone”) – DNF‑10 helps reduce ghrelin signaling so you feel less hungry. CCK (cholecystokinin) (“fullness hormone”) – DNF‑10 helps increase CCK, making you feel full/satisfied sooner. Elisha's personal experience: Used it to help lose a few pounds before her wedding and to control cravings after a carb‑heavy honeymoon in Italy. Reports feeling less snacky in the afternoons despite the tempting snacks at Nutrition World. Notes customers are consistently “wowed” by the effect on appetite Product forms and dosing: Powder in flavors like guava grapefruit and chocolate (which she says tastes like brownie). Capsules: typically 2 per day. Can be mixed with: Ancient Nutrition's A2 protein powder after lunch. Or simply with water. [0:24:35]  AMPK, Berberine & Metabolism Support Products Alicia introduces Life Extension AMPK Metabolic Activator: AMPK is described as a master cellular switch in every cell — like the light switch in your house showing you what needs cleaning. Supports cellular cleanup and improves handling of belly/visceral fat, the dangerous fat around organs. Typical study protocol: 12–16 weeks (3–4 months) for notable changes. Usually 1 capsule per day. Ed references Dr. David Sinclair and the role of AMPK (and NMN) in longevity, noting strong safety when aiming to restore normal function, not push extremes. Berberine: Also activates AMPK. Mimics some effects of metformin: supports blood sugar balance and metabolic health. Very safe overall, though some experience GI upset; Ed notes finding a brand that minimized stomach issues. Nutrition World pharmacist Dr. Curt Dearing frequently recommends it. Life Seasons Metabolism Formula: Designed to boost resting metabolic rate rather than affect satiety. Key ingredients mentioned: Green tea (thermogenesis) Cayenne pepper (metabolic “furnace”) Theobromine (mild stimulant for energy without jitters) Theanine (calming) Cacao (hormonal and metabolic support) Green coffee bean (via chlorogenic acid; supports liver and moderates sugar release, especially in fasting). Ed recalls the Dr. Oz–era fad around green coffee bean and notes that while it was overhyped, it does have real, modest benefits when used correctly and not as a “magic pill.” Ed describes his own experience: Training for the Chattanooga Fitness bodybuilding event. Cut calories by ~40% for the first time at age almost 69, but only lost about 7 pounds, illustrating slower metabolism with age. Elisha emphasizes: These products are tools, not replacements for macros, exercise, and lifestyle. Goal is to raise resting metabolic rate and support what diet and training are already doing. Elisha notes peptides are fine in the evening (non‑stimulating) but the Metabolism formula should be used earlier in the day due to its stimulating ingredients. [0:37:39] Aging, Eye Strain Ed reframes healthy aging: Less about reaching extreme ages (e.g., 120+) and more about strength, clarity, mobility, and energy in the years you do have. Notes concepts like a “heartbeat quota”—a rough idea that we have a finite number of heartbeats. Discusses modern eye strain from constant near‑focus screens: Historically, humans mostly focused on distant objects. Screen use reduces blinking from about 15 times/min to 5–7 times/min, leading to dry, strained eyes. Recommends the 20‑20‑20 rule: every 20 minutes, look 20 feet away for 20 seconds. Mentions lutein and zeaxanthin from green vegetables as supportive eye nutrients. [0:40:51] Teflon, & philosophy on chemicals Ed shares a household tip: He uses green, non‑toxic stainless steel cookware (360 Cookware) but scrambled eggs stick badly. His sister suggested Dawn Powerwash, which worked exceptionally well on the pan. Clint notes he uses non‑stick pans where food slides right out. Ed warns: Many non‑stick pans (e.g., classic Teflon) can contain “forever chemicals”, potentially harming hormones and long‑term health. Philosophical tension: Show is generally pro‑“green pharmacy” and low‑chemical living, but Ed acknowledges sometimes selective use of effective products (like Dawn Powerwash) can be very helpful if used sparingly and thoughtfully. [0:42:15]  Intermittent fasting & hair loss Ed shares findings from a new research study linking intermittent fasting with increased hair loss: During fasting, the body shifts from glucose to fat as fuel. Hair follicle stem cells strongly prefer glucose; forcing them to rely on fat can stress or damage them. Fasting may flood follicles with toxic fatty acids, especially in the presence of widespread seed‑oil consumption (canola, generic “vegetable oils,” etc.). Reinforces Ed's long‑standing reservations about intermittent fasting: Risk of insufficient protein, leading to muscle loss and higher mortality. Harder to build muscle within a restricted eating window. Adds this hair loss risk as another factor against aggressive fasting for many people. [0:44:59] Tinnitus & diet Study highlights dietary links for tinnitus (ringing in the ears): Higher fruit consumption correlates with lower odds of developing tinnitus. Butter and legumes appeared to calm tinnitus symptoms. MSG and aspartame/Nutrasweet can worsen tinnitus by overstimulating nerves. [0:46:00] Safer bug repellents Ed discusses concerns with DEET: Effective but not ideal for frequent or heavy use, especially on children and over large skin areas. Introduces picaridin (he pronounces it like “Picardian”): 20% picaridin spray is comparable to DEET for repelling mosquitoes and ticks. Has a better safety profile, less damaging to fabrics, and is Ed's top chemical alternative to DEET. Natural/green options: Lemon eucalyptus oil and similar formulas can repel mosquitoes for up to 6 hours. Nutrition World carries options like Trek and “Extra Strength Tick Repellent,” which Ed's family uses directly on skin, especially for his grandkids. [0:54:08] Resistance Training, Longevity, Mindset on Medicine vs. Nature Ed cites a study from the British Journal of Sports Medicine: 90–119 minutes per week of resistance training associated with: 13% lower all‑cause mortality. 19% lower cardiovascular mortality. 27% lower mortality from neurological diseases, particularly dementia‑related. Reiterates: Exercise is the most reliable “elixir” of longevity. Emphasizes that quality of life and cognitive health are at least as important as adding years. Ed quotes Andrew Kaufman, MD, who advocates: Strong belief in natural healing and the body's innate ability to self‑regulate. Skepticism toward new pharmaceuticals and product trends. “Your body is always working in service to your healing.” Ed adds his own nuance: There is an important role for short‑term pharmaceuticals, surgeries, and acute interventions when life‑saving. But defaulting to nature and lifestyle first, with drugs as Plan B, is his guiding model. Clint points out that practitioners who have worked both in conventional and integrative spaces can often offer the best balanced guidance, understanding both toolkits without being dogmatic. [0:56:15]  Final reflections & closing Ed summarizes: The world can be divided into “learners and non‑learners,” and listeners of the show are very much in the “learner” camp. The show's mission is to give practical, immediately usable health strategies that often aren't emphasized in conventional appointments. Clint highlights: We can't control everything (genetics, some disease), but having things we can control (diet, movement, sleep, supplements, environment) gives confidence and calm. Ed emphasizes the phrase: “Genes load the gun; lifestyle pulls the trigger.” Good habits can keep risky genes silent much longer The post Radio Show / Podcast – June 21, 2026 first appeared on Vital Health Radio.

Your body after a baby was never a calorie problem. It is a metabolic one. In this Her Stack episode I am walking you through exactly how to restore your metabolism so body composition follows. The goal is not weight loss. The goal is metabolic restoration. Body comp is downstream. I am breaking down the four drivers that actually run body composition (insulin, thyroid, sleep, growth hormone), the four pillars to address them (nutrition, lifestyle, supplements, peptides), and the exact peptide sequencing for women. Plus my honest take on GLP-1s including semaglutide, tirzepatide, and retatrutide, where they actually fit, and why microdosing makes more sense than chasing the scale. I also share what nobody talks about. Eating less postpartum often makes body composition worse. Breastfeeding is sequencing, not failure. Growth hormone is the layer women never hear about, so they plateau and blame their age when it was a fixable signal the whole time. Join The LongHer Life for women-specific guidance on peptides, hormones, and longevity.   I TALK ABOUT: 00:00 Welcome back to the Her Stack series 00:53 Updates: working with me one-on-one and my new peptide planner 06:15 Why body composition not weight, and why metabolism not calories 07:01 The four drivers and four pillars framework 09:00 Driver 1: Insulin resistance and why stubborn middle fat is an insulin problem, not a calorie problem 11:30 Driver 2: Thyroid, and why TSH alone misses Free T3 (the worker hormone) 14:50 Driver 3: Sleep, cortisol, and the loop back to insulin resistance 19:32 Driver 4: Growth hormone, the layer nobody talks about that's blunted postpartum and through aging 22:19 The labs to actually ask for: fasting insulin, Free T3, IGF-1, DHEA-S, plus a 2-week CGM 24:30 Pillar 1: Nutrition (protein floor of 120g, leucine at every meal, food order, fiber, and why you should NOT under-eat) 28:06 Why leucine flips the muscle-building switch 35:00 Pillar 2: Lifestyle and biohacking (lift 3x a week, walk 7-10k steps, zone 2, cold and heat, red light, and the fringe tier honestly) 45:30 Pillar 3: Supplements (creatine, magnesium glycinate, myo-inositol, omega-3, berberine, and breastfeeding sequencing) 51:01 Berberine, AMPK, and "nature's metformin" 55:30 Pillar 4: The peptide stack starts here with AOD-9604 56:00 AOD-9604, the growth hormone fragment, why I am personally taking it right now 01:02:00 MOTS-c, the "exercise in a molecule" mitochondrial peptide 01:05:00 5-Amino-1MQ and releasing the brake on fat cells 01:07:00 Sermorelin, the gentle GH entry (what a secretagogue actually is) 01:10:00 CJC-1295, Ipamorelin, and Tesamorelin for post-weaning GH restoration 01:13:00 The GLP-1 honest take: semaglutide, tirzepatide, and the retatrutide question 01:14:00 Why retatrutide is called the triple agonist and where it fits (and where it doesn't) 01:19:27 Recap and wrap-up   RESOURCES: Work with me one-on-one on your peptide stack and protocol. The Her Stack Planner, the first peptide tracking journal built around female biology. Free Peptide Masterclass for Women. Join The LongHer Life for women-specific guidance on peptides, hormones, and longevity.   LET'S CONNECT: Instagram, TikTok, Facebook Shop my favorite health products Listen on Spotify, Apple Podcasts, YouTube Music

If you're training consistently, eating healthy, and still struggling with muscle loss, slower recovery, stubborn body composition changes, or feeling like your metabolism simply doesn't work like it used to… this episode is for you. In this deep-dive conversation, I sit down with Dr. David Minkoff, physician, endurance athlete, and founder of BodyHealth, to explore what is really happening beneath the surface as we age—and why muscle health may be one of the biggest missing pieces in longevity, metabolism, and performance. We discuss: • Why muscle loss accelerates after 40—even if you exercise consistently • What anabolic resistance is and why building muscle becomes harder with age • The difference between AMPK (survival mode) and mTOR (build mode) • What muscle protein synthesis (MPS) actually means and how to stimulate it • Why simply "eating more protein" may not solve the problem • The importance of digestion, stomach acid, and protein utilization • Why reaching the leucine threshold matters for muscle repair and growth • The science behind essential amino acids (EAAs) and recovery • How under-fueling, overtraining, poor recovery, and chronic stress can keep you stuck • Why muscle is critical for blood sugar regulation, energy, metabolism, and healthy aging If you're a high performer, endurance athlete, active adult, or someone navigating midlife changes and wondering why your body no longer responds the way it used to—this conversation will help connect the dots. Because many active adults are not undertrained.  They are under-muscled.  And the solution may not be working harder. It may be learning how to send a stronger signal. Resources & Next Steps Support muscle protein synthesis and recovery with Perfect Aminos: https://www.bodyhealthaffiliates.com/42D431W/3QQG7/ Learn more about the 30-Day Muscle & Metabolism Reset: https://debbiepotts.net/30-day-group-program/ Explore coaching, testing, and your personalized FutureYou Blueprint: https://www.debbiepotts.net Remember:  You do not need more effort.  You need better signals.  Build muscle. Restore metabolism. Become your strongest Future You. Educational purposes only. Please consult your qualified healthcare practitioner before making changes to your nutrition, supplements, medications, or exercise program.

Hosts: Ed Jones (Owner – Nutrition World) & Clint Powell A variety of topics for living a healthy life Presented by: Nutrition World www.nutritionw.com Broadcasting from the Nooga Dentistry Studio www.noogadentistry.com Production of: Whitfield Media Group www.vitalhealthradio.com Title: Digestive Enzymes, Gut Health, and Omega-3's with Guest Brenda Watson [0:00:00] Show Intro,  National Club Foot Day & Prior Episode Reference Ed mentions National Club Foot Day (previous Wednesday). References a prior Vital Health Radio episode where he strongly criticized a local Chattanooga physician for poor club foot care that nearly harmed his grandson. Ed urges: Anyone with a child/grandchild with club foot seeing providers in Chattanooga  listen to our Feb 15th (2026) episode Contact: NutritionWorld@comcast.net to get details of that show and the physician referenced. Emphasis on truth, empowerment, and avoiding harm from medical “inefficiency and ignorance.” [0:03:58] Delta-8 Gummies, Anxiety/Sleep & Lifespan Extension Concepts Recap of a recent show with Hemp House. Ed explains: Only about three weeks left to legally purchase Delta-8 gummies at Hemp House or Nutrition World. Why someone might use Delta-8: Anxiety Trouble sleeping Need to stay functional but calmer Must find the right dose individually (no standard dosing). Safer than many anti-anxiety drugs when used properly. He is saving several containers in his freezer for future “bumps in the road” (periods of poor sleep or high stress). Notes dogs may benefit for anxiety, thunder phobia, pain, etc., when used correctly and from a trusted company. Ed recommends Dr. David Sinclair's “Lifespan” podcast: Focus on practical drugs, supplements, and lifestyle strategies to extend lifespan. Central concept: cellular repair – if we repaired cells at 50 as well as at 20, lifespan could drastically increase. Key tools Dr. Sinclair highlights (as relayed by Ed): Rapamycin – Ed takes this drug himself; impacts mTOR; can extend lifespan even when started later in life. AMPK activators – sold at Nutrition World; support clearing out old/dysfunctional cells. Resveratrol – mimics some effects of fasting. Hyperbaric oxygen – discussed as a potential lifespan extender. Ed shares Sinclair's animal-longevity illustrations: A mole rat living ~20x longer than regular rats → proves there are mechanisms of extended lifespan. A long-lived whale (Clint jokes and riffs on the name) said to reach ~200 years, suggesting humans might mimic similar mechanisms. [0:08:46] Call for Listener Stories & Introduction of Guest Brenda Watson Ed invites listeners to share personal health recovery stories, especially involving “the Green Pharmacy” (natural, nutritional, and lifestyle approaches, including Nutrition World support). Announced collaboration with Clint Powell on a new podcast: Short, credible motivational/educational stories (5–20 minutes). Focus: “I was in bad shape, now I'm much better” recovery narratives. Participants receive a $50 Nutrition World gift card. Recordings at a studio ~5 minutes from Nutrition World. Introduction of guest Brenda Watson, founder of Vital Planet. Described as a guru of gut health and the microbiome: Leaky gut, SIBO, broad digestive health expertise. Ed recalls her long-running NPR fund-raiser specials on gut health that reached tens of thousands. [0:13:25] Digestive Enzymes, Gut Health & Problems with Acid Blockers Topic: What is an enzyme? Why does it matter? Brenda's explanation: Enzymes “break things apart”: Protease → breaks proteins into amino acids. Amylase → breaks starches into glucose. Lipase → breaks fats into fatty acids. Ideally, stomach, pancreas, liver, and gallbladder work together to digest food into absorbable units. Early digestive symptoms: Heartburn, gas, bloating, etc. Many people self-treat with OTC antacids or proton pump inhibitors (PPIs) and this often worsens underlying issues. Her main point: For early digestive symptoms, start with a full-spectrum digestive enzyme (protease, amylase, lipase) with meals, not acid-blocking drugs. As we age, natural digestion weakens, compounded by poor food quality. If food is not properly digested: It rots in the gut → gas, overgrowth of “bad bugs”. Contributes to SIBO, leaky gut, and broader dysbiosis. Leads to poor absorption of nutrients and worsening health. Enzymes as Step One: Should be a first-line intervention alongside or even before probiotics. Emphasizes that digestive enzymes for digestion must be taken with meals. Brenda notes she ran a stool test program with 12 people; often saw imbalanced gut bacteria driven by undigested food. Modern enzyme formulations can be more targeted: Gluten-support enzymes. General high-potency formulas. Formulas for dairy and fat, especially for people on keto who need extra fat-digesting support. She reiterates: Poor digestion = bad bacteria, leaky gut, SIBO, multiple gut issues. Digestive enzymes are a “no-brainer” first step when digestive symptoms appear. [0:23:47] Enzymes as a Foundational Strategy & Aging, Pancreas/Bile Physiology Emphasizes: Rotting food analogy: leftover food in a trash can on a 97°F day = what undigested food can be like inside the gut. Even without symptoms, after age ~40–45, enzymes may be wise especially for people who: Overeat Eat a lot of dairy or gluten Notes loose stools and general poor health can be caused by lack of pancreatic enzymes. Shares a case where a client's stool test showed zero pancreatic enzyme production, correlating with constant sickness. You can “get away with” some other health issues, but you cannot have a dysfunctional digestive tract and still expect even average health. Brenda further explains physiology and pH: Stomach should be very acidic (pH ~2) during digestion. When partly digested food moves into the small intestine: Bicarbonate is released to neutralize acid. Pancreas releases enzymes (protease, amylase, lipase). Liver/gallbladder release bile for fat digestion near the same region. If stomach acid is suppressed, the chain reaction is disrupted: Poor enzyme activation. Poor bile function. pH shifts can foster candida and other imbalances (e.g., colon getting too alkaline). She underscores: From mouth to colon, each region needs appropriate pH. Chronic use of acid blockers has long-term downstream consequences. Ed mentions a simple at-home baking soda test to roughly gauge stomach acid (baking soda in water between meals, watching for burping). Important caution: If you're on acid-blocking medications, you must wean off slowly; do not stop abruptly. Nutrition World's pharmacist, Dr. Curt Dearing, helps people step down from PPIs and H2 blockers safely (in partnership with their physicians). [0:30:58] Omega-3s , Purity, and Heart/Brain Health Ed highlights Vital Omega (Vital Planet): #1 selling product at Nutrition World. Exceptional purity and transparency (heavy emphasis on contaminant-free sourcing). Very high potency (2350 mg of EPA/DHA per serving). No “fish burp” complaints and virtually no returns. Contains lipase enzyme to support fat digestion and further reduce digestive discomfort. Omega blood tests on customers show high omega-3 levels when using this brand. Brenda agrees: Omega-3s are critical at any age, especially in today's toxic environment. You might skip a multivitamin, but you should not skip omega-3s. Ed's additional points: Olive oil and flax oil are not the same as concentrated EPA/DHA. EPA/DHA are essential for cell membranes, cardiovascular health, and cognitive function. Warns of contaminated fish oil from polluted waters (mercury, heavy metals, etc.). Website plug for Vital Planet: VitalPlanet.com for education, and product details. Ed reiterates his respect for Brenda's decades of ethical, passionate work and says they'll have her back on again.   [0:38:54] Lifestyle, Local Food, Pillows, and Environmental Toxins Ed and Clint return; Ed summarizes the show's philosophy: Better aging is about strength, clarity, mobility, energy, not just added years. Introduces term “peak span”, maximizing the years we're at peak function, not just lifespan. Critiques normalization of poor health (hunched posture, chronic pain, poor sleep, anxiety) as “just getting old.” Local food talk: Discussion of Tallow House in Cleveland (burger restaurant, cousin of Tony from Portofino). Two-hour waits, excellent reviews, smash burgers, buns from Neidlovs bakery. Dust mites and pillows: Ed cites data that about 1/3 of a pillow can be dead skin + dust mites over time. Many pillows also contain fire retardant chemicals leading to chronic exposure while sleeping. Ed searched for non-toxic pillows via Mamavation: A site that tests products for chemical residues and rates them. His previous pillow (from Avocado) came out top-rated, so he bought a new Avocado pillow. Recommends buying via Mammovation's affiliate link for a small discount. [0:44:00] Essential Oils, Green Pharmacy & Polypharmacy Ed on essential oils quality: A test of 20 lavender oils from Amazon found: Only 3 were pure. 17 were diluted/contaminated with other oils. Smell alone isn't a reliable indicator of quality. Nutrition World only carries brands with Certificates of Analysis; dropped an entire line a few years back over quality concerns. Ed shares a Taiwanese blood pressure study: 58 adults with high blood pressure, many on meds. wore a face mask with a cotton pad containing small amounts of real lavender oil for 15 minutes/day over 7 days. Result: systolic blood pressure reduced by ~10 points. A placebo (fake) oil did not reduce blood pressure. One-day use showed no benefit – consistent use was required. He frames this as an example of the “Green Pharmacy”: Mentions Dr. Curt Dearing (pharmacist at Nutrition World): Helps people review and rationalize medication lists, with the goal of reducing polypharmacy in collaboration with prescribing doctors. References a recent Vital Health Radio episode on polypharmacy (average American takes ~17 prescriptions per year). [0:56:48] Meditation, Mindset, Ancient Wisdom & Fulfillment Story from the Daily Stoic: Kurt Vonnegut and Joseph Heller at a billionaire's party: Vonnegut points out the host made more money yesterday than Heller's Catch-22 ever did. Heller replies he has something the billionaire never will: “the knowledge that I've got enough.” Ed uses this to emphasize: The power of knowing you have enough. Shifting from chasing money to working for fulfillment once basics are covered. Clint adds: You must learn to be content with what you have while still pursuing goals. More stuff doesn't automatically create a content person. Ed reads a longer reflection on “ancient wisdom” vs. modern medicine: Fundamental philosophy: alignment with nature. Humans thrived for millennia without pharmaceuticals (acknowledges infectious disease issues before hygiene and antibiotics). Nearly every drug has unintended consequences and rarely treats root causes. Cites estimate: medical errors as the 3rd leading cause of death in the US (~250,000 deaths/year). Notes ~90% of American calories now come from processed foods and seed oils Argues seed oils are among the most destructive components of the modern diet. Many cardiologists still recommend them as heart-healthy, highlighting the conflict between mainstream and holistic views. Plug for Ed's book: “Are You Sick and Tired of Being Sick and Tired” available at TheHolisticNavigator.com, built around ancient wisdom.  The post Radio Show / Podcast – June 7, 2026 first appeared on Vital Health Radio.

Sulforaphane, Detox Pathways, and the Science of Microplastic Removal Microplastics are building up inside your brain, blood, and reproductive tissue, and most detox protocols do nothing to remove them. This episode gives you the cellular science behind why toxins accumulate, which three detox pathways control your ability to excrete them, and what the latest research shows actually moves microplastics, heavy metals, BPA, and benzene out of your body.. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -For next week, 25% off all Mara Labs products when you go to www.mara-labs.com/DAVE and use code DAVE at checkout. After June 11th, the code will return to the standard 15% off. Host Dave Asprey sits down with Dr. John Gildea, a Johns Hopkins-trained PhD with 60 scientific publications and over 20 NIH-funded studies, and David Roberts, co-founder of Mara Labs and co-creator of BrocElite, the only naturally derived stable form of sulforaphane available in a capsule. Together they bring decades of research-backed biohacking and functional medicine insight into one of the most pressing longevity conversations of our time. They break down the lysosome, your cell's built-in incinerator, and explain exactly why it gets clogged with microplastics, advanced glycation end products, and other toxins that won't break down. New research shows that sulforaphane triggers a process called lysosomal surface translocation, which releases those trapped particles so your body can finally excrete them. An in-house Mara Labs study confirmed the excretion pathway: microplastics come out in feces. In the original study, the individual measured the highest microplastic levels ever recorded, and a repeat study a year later showed dramatically lower baseline microplastic levels, suggesting consistent use compounds the benefit over time. You'll Learn: Why microplastics accumulate inside lysosomes and what sulforaphane does to release them How the three detox pathways, glutathione, glucuronidation, and sulfation, work together to remove every major class of toxin What an in-house study revealed about how and where microplastics actually leave the body How toxic estrogen metabolites form and why sulforaphane is the most effective natural tool to reroute them Why berberine supports sleep optimization, ketosis, and blocks a cancer growth pathway most drugs cannot touch How sulforaphane boosts BDNF and neuroplasticity at the cellular level What microplastic sources in your home, including your dryer, rugs, and receipts, are doing to your toxin load daily Why losing weight releases stored toxins and what to take to protect your brain and metabolism during fat loss How sulforaphane activates the same AMPK longevity pathways triggered by fasting without restricting food Thank you to our sponsors! - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE - HeartMath | Go to https://www.heartmath.com/dave to save 15% off. - Timeline | Go to timeline.com/dave and you'll get an additional 20% off your first month - Our Place | Stop cooking with toxic cookware and upgrade to Our Place today. With a 100-day risk-free trial, plus free shipping and returns, you can experience this game-changing cookware with zero risk. Visit: fromourplace.com/DAVE Use code: DAVE for 10% off sitewide Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Dr. John Gildea, David Roberts, Mara Labs, BrocElite, sulforaphane, microplastics, microplastic removal, lysosome, lysosomal surface translocation, detox pathways, glutathione, glucuronidation, sulfation, Nrf2 pathway, AMPK, TFEB1, BDNF, neuroplasticity, heavy metals, BPA, benzene, estrogen metabolism, toxic estrogen, xenoestrogens, berberine, BerbaLite, ResveraLite, c-Myc, cancer and estrogen, sleep optimization, ketosis, broccoli sprouts, isothiocyanates, PEITC, watercress, phase two detox, microplastic excretion, indoor air quality, HEPA filter, dryer lint microplastics, BPA receipts, endocrine disruptors, fat loss and toxins, autism and sulforaphane, ADHD and focus, vivid dreams and BDNF, fasting mimicry, anti-aging, biohacking, longevity, functional medicine, supplements, human performance, brain optimization, metabolism, cellular detox Resources: • For next week, 25% off all Mara Labs products when you go to www.mara-labs.com/DAVE and use code DAVE at checkout. After June 11th, the code will return to the standard 15% off. • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 0:00 – Trailer 1:55 – Intro & Context 4:48 – Microplastics & Sulforaphane 12:39 – Broccoli Sprouts Formulation 15:20 – Lab Origin Story 26:01 – Reducing Toxin Exposure 37:06 – Estrogen, Hormones & Berberine 52:46 – Autism, ADHD & Brain Health 59:01 – Wrap-Up See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Dr. Corey Schuler, PhD(c), FNP, DC, CNS, and director of medical affairs at Allergy Research Group, details his paper “Energy Allocation Resilience and Endocrine Integration” in the International Journal of Molecular Sciences. He introduces the Energy Allocation System (EAS), which emphasizes how the body allocates energy—not just produces it—and links many symptoms to impaired bioenergetics and resilience. They discuss mitochondria as energy generators and cellular signaling hubs, the integrated stress response and endocrine coordination (HPA axis, thyroid, gonads), and mitohormesis/eustress (exercise, fasting, heat/cold, circadian “zeitgebers”). Schuler explains nuanced testing for fatigue (diurnal cortisol, CGM patterns, thyroid markers including T3/reverse T3) and a case of a perimenopausal woman where oral contraceptives and cortisol dysregulation affected glucose patterns. They cover mitochondrial support (removing obstacles like pollutants/antibiotics, triglycerides, carnitine, dietary fats, micronutrients) and pacing/sequencing lifestyle interventions.

What if your skin could literally rebuild itself from the inside out? In this episode, we break down one of the most powerful and misunderstood biological processes in the human body: autophagy.From its Nobel Prize-winning discovery to the molecular machinery that drives it, we walk you through exactly what autophagy is, how it works at the cellular level, and why it matters far more than most people realize for skin aging.We explore the two master switches that control autophagy, mTOR and AMPK, and how the constant tug of war between them determines whether your cells are in build mode or cleanup mode. We also explain why most people in the modern world are stuck in permanent mTOR activation, and what that means for how their skin ages over time.This is Part 1 of our deep dive. In Part 2, we go skin-specific and break down exactly how autophagy renews your skin at the tissue level.What's Discussed:(0:19) The "phoenix process": the cellular mechanism rebuilding your skin from the inside out(3:14) What autophagy actually means, and why the science world ignored it for 30 years(4:47) How baker's yeast cracked the code that won the 2016 Nobel Prize(7:14) Inside a single skin cell: the step-by-step breakdown of how autophagy actually works(10:22) Why autophagy is not destruction, and what this means for your collagen supplements(16:44) The two master switches controlling whether your cells build or clean(20:10) The everyday habit silencing your body's most powerful anti-aging system(26:17) Why aging skin isn't broken, it has just never been told to cleanResources Mentioned:Biohacking Beauty Podcast: Ben Azadi: Why 93% of Americans Are Aging Too Fast + What to Do About It: podcasts.apple.com/us/podcast/ben-azadiFind more from Young Goose:Use code PODCAST10 to get 10% OFF your first purchase, and if you're a returning customer use the code PODCAST5 to get 5% OFF at younggoose.comInstagram: @young_goose_skincare

Chronic stress belly fat is more than a feeling — it changes your hormones, metabolism, and cravings. Nurse Doza breaks down 5 specific mechanisms — cortisol, insulin resistance, leptin dysfunction, fatty liver, and late-night eating — explaining exactly why belly fat won't budge and what to do about it. FEATURED PRODUCT:  The Metabolic Pack from MSW Nutrition is the complete protocol for everything covered in this episode. Liver Boost combines turmeric (curcumin), green tea extract (EGCG), NAC, and alpha-lipoic acid to reduce inflammation, support liver detoxification, and combat insulin resistance at the cellular level. Mitochondriac delivers resveratrol and key mitochondrial support to activate AMPK, improve cellular energy, and lower inflammatory markers linked to chronic stress and weight gain. Zen contains an adaptogenic blend with Rhodiola, Ginseng, Eleuthero, Schisandra, and bovine adrenal glandular support — specifically designed to regulate cortisol and protect adrenal health. Together, these three supplements form a 60–90 day metabolic reset built to address the root causes of chronic stress belly fat.

Chronic stress belly fat is more than a feeling — it changes your hormones, metabolism, and cravings. Nurse Doza breaks down 5 specific mechanisms — cortisol, insulin resistance, leptin dysfunction, fatty liver, and late-night eating — explaining exactly why belly fat won't budge and what to do about it. FEATURED PRODUCT:  The Metabolic Pack from MSW Nutrition is the complete protocol for everything covered in this episode. Liver Boost combines turmeric (curcumin), green tea extract (EGCG), NAC, and alpha-lipoic acid to reduce inflammation, support liver detoxification, and combat insulin resistance at the cellular level. Mitochondriac delivers resveratrol and key mitochondrial support to activate AMPK, improve cellular energy, and lower inflammatory markers linked to chronic stress and weight gain. Zen contains an adaptogenic blend with Rhodiola, Ginseng, Eleuthero, Schisandra, and bovine adrenal glandular support — specifically designed to regulate cortisol and protect adrenal health. Together, these three supplements form a 60–90 day metabolic reset built to address the root causes of chronic stress belly fat.

In this episode, Dr. Jockers breaks down the science of autophagy and mTOR, two crucial processes for cellular repair and growth. Learn how balancing these pathways is key to slowing down aging and optimizing longevity. Discover the powerful impact of fasting, exercise, and ketosis on activating autophagy and inhibiting mTOR. Dr. Jockers explains how these strategies help reduce inflammation and promote healthy muscle mass. You'll also hear about the best foods and supplements to support your body's natural healing processes. From polyphenols to intermittent fasting, this episode gives you the tools to boost cellular regeneration and maintain vitality. In This Episode:  00:00 Autophagy Basics 00:23 Podcast Intro and Resources 03:28 mTOR Explained 04:21 Autophagy and AMPK 05:11 Longevity Risks and Balance 07:10 How to Inhibit mTOR 08:55 What Increases mTOR 12:21 Exercise Spring Load Strategy 13:22 Fasting Window and Meals 16:17 Longevity Takeaways and Outro   Unwind with Purality Health's KSM 66 Ashwagandha, clinically proven to reduce stress and improve overall health. Its advanced nano-absorption technology ensures you get this ancient herb's full benefits. Experience better sleep, enhanced memory, and a calmer mindset. Enjoy a special buy one, get one free offer now! Each order comes with a six-month satisfaction guarantee. Visit longevityroot.com/drj to claim your deal and start feeling less stressed today. Say goodbye to unhealthy cooking oils and elevate your meals with Kettle & Fire's 100% grass-fed beef tallow. Free from seed oils and preservatives, it's the cleanest, healthiest fat you can use for cooking. With a high smoke point of 420°F, it's perfect for grilling, roasting, and sautéing, bringing both great flavor and nutritional benefits. For a limited time, enjoy 25% off sitewide with the code DRJOCKERS at checkout. Visit kettleandfire.com/drjockers to shop now!   "Autophagy clears out what's broken so your body can rebuild stronger, cleaner, and more efficient cells." ~ Dr. Jockers   Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean TuneIn Radio     Resources: Visit renewyourhair.com/drj to claim your exclusive offer Visit kettleandfire.com/doctorjockers with the code DRJOCKERS   Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https:/www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/   If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/ 

Your cells start failing at 35. Dr Sandra Kaufmann reveals the 7 systems breaking down — and how to stop it. Your cells start failing at 35. Dr Sandra Kaufmann reveals the 7 systems breaking down — and how to stop it.

Your day is getting programmed whether you choose it or not, and the “golden hours” after waking and before sleep are where that programming sticks. I walk through what's happening in the brain and nervous system during those windows, why we're more suggestible and neuroplastic, and how a few small choices can shift your baseline from reactive to regulated. If your mornings start with scrolling, stress, and quick dopamine hits, you may be teaching your body to crave agitation, distraction, and tunnel vision all day long.I share my flexible, repeatable morning routine built around spirit, mind, and body: meditation done out of bed, intention setting that acts like a GPS for your subconscious, and gratitude to create heart-brain coherence. We also talk about discipline versus willpower, how to create natural dopamine through learning, and how movement and breathwork help clear cortisol so you can think bigger, feel steadier, and respond instead of react. These are practical nervous system regulation tools you can adapt to any season of life.Then we pivot to a topic I'm seeing everywhere: protein. Can you overdo it? Absolutely. I explain why protein can still drive insulin, how excess can spill over into glucose production and fat storage, and which symptoms can signal “too much” for your body, from digestion and dehydration to sleep disruption and hot flashes. We zoom out into pathways, not just macros, comparing mTOR and IGF-1 growth signaling with AMPK, ketosis, and autophagy so you can balance building muscle with cellular repair, metabolic health, and long-term longevity.If you're ready to stop copying influencers and start listening to your biofeedback, press play, then subscribe, and share this with a friend who's stuck in health noise!To work one-on-one with me, you can apply HERE!To get notified as soon as groups open up and other updates sign up/subscribe here:https://stacy-baker.mykajabi.com/opt-in-9cffc5f4-f006-4adb-a0a7-6c33a0698b4bResources mentioned:Ketone and Blood Sugar Testing MasterclassKetone TestingRa Optics (Code DRSTACYND) blue light blockersHigher Dose (my FAV sauna blanket with low to no EMF) code DRSTACYCGM *2 months free with code DRSTACYStructured/Living Water *code DRSTACYSpring Aqua (my FAV water system) For more from me, follow me on IG @dr.stacy.ndEpisodes Mentioned: Dairy Paradox/Insulin Impact Calorie Deficit versus FastingThank you for listening! This information is just that; information only - not to be taken as medical advice. Please contact your primary care before changing anything to your routine. This information is not mean to diagnose, treat, or cure disease.

Most of the NAD+ skincare on shelves right now is built on a misunderstanding. And if you've been trusting niacinamide to do the heavy lifting, this episode is going to change how you read a label.This episode is Part 2 of our NAD+ deep dive. Here, we get into what actually works to raise NAD+ in the skin, the real precursors, the delivery technology that gets them where they need to go, and the mitochondrial support system most brands leave out. We also walk through the lifestyle levers that move the needle, and why one of them becomes non-negotiable for women after a certain age.If Part 1 explains what steals your NAD+, this episode is where the science gets practical and eye-opening.What's Discussed:(5:07) What the clinical data actually says about topical niacinamide(7:21) Why most niacinamide products on your shelf are underdosed(8:16) The roundabout pathway that makes niacinamide a poor NAD+ precursor(9:03) Niacinamide is a brightening agent, not an NAD+ booster(10:15) Why NMN can't cross the skin barrier alone(11:19) CD38 and blocking the enzyme that destroys NAD+(13:03) NAD+ alone is potential energy, not usable energy(13:45) Liposomal encapsulation and how real precursors get into the skin(17:02) The five mitochondrial pathways your skin actually needs(18:53) Senescent cells and the next telomeres conversation(25:17) Why NAD Apex targets NAD+ in three dimensions(26:39) Lifestyle strategies: fasting and the AMPK pathway(28:47) How to get 30 to 50% more NAD+ from caloric restriction through fasting(30:37) The fun fact behind why 16:8 fasting became the standard(33:02) HIIT and its compounding effect on baseline NAD+(34:51) Sleep is an NAD+ dependent repair session, not just rest(39:15) Your skin does 8x more renewal at night(41:38) Sun protection as an NAD+ strategy(44:49) Why you should expose your back more than your face(45:29) Contrast therapy, heat shock proteins, and cold-driven biogenesis(50:32) Why stacking NAD+ boosting activities at 50% beats maxing out one modality(52:49) The perimenopause problem no one is talking about(56:29) Why niacinamide creates homework for the body(1:01:46) You recycle more NAD+ daily than you can ever supplement(1:02:19) 5-Amino-1MQ, the peptide that recycles NAD+(1:05:35) Mitophagy, autophagy, and the role of spermidine(1:06:44) Ergothioneine, the only antioxidant with a direct mitochondrial transporter(1:07:46) Fermented resveratrol and activating SIRT1Check out resources mentioned:Part 1 of our NAD+ deep dive: The NAD+ Thief Your Skin Can't Escape: CD38, Zombie Cells, and the DeclineCheck out our NAD+ Guide: NAD+ & SKIN AGING - The Cellular Energy ConnectionSleep is Skincare episode: How Timing Unlocks Your Body's Best Skincare RepairFind more from Young Goose:Use code PODCAST10 to get 10% OFF your first purchase, and if you're a returning customer use the code PODCAST5 to get 5% OFF at https://younggoose.comInstagram: @young_goose_skincareVampire Exosomes: Professional Exosome Serum for Regeneration and Post-Treatment Recovery https://younggoose.com/products/vampire-exosomes

Cancer has long been understood through a variety of biological frameworks, including genetic mutations, dysregulated signaling pathways, and uncontrolled cell proliferation. Yet, these models often capture the visible consequences of disease rather than the deeper metabolic dependencies that sustain tumor survival. Despite major advances in targeted therapies, a central challenge remains: what underlying mechanisms make cancer cells vulnerable to treatment, and how can these vulnerabilities be exploited more effectively? Increasing attention has shifted toward cellular metabolism—particularly lipid regulation and energy-sensing pathways such as AMPK—as critical determinants of tumor behavior. Scientists are now taking a closer look at how metabolism works together with stress responses like autophagy—and how this connection could be used to develop better cancer treatments. A new research paper was published in Volume 17 of Oncotarget, titled “The SCD1 inhibitor aramchol interacts with regorafenib and metformin to kill tumor cells.” The study was led by first author Michael R. Booth and corresponding author Paul Dent from Virginia Commonwealth University, in collaboration with Laurence Booth and Jane L. Roberts from Virginia Commonwealth University and John M. Kirkwood from the University of Pittsburgh Cancer Institute. Full blog - https://www.oncotarget.org/2026/04/21/scd1-inhibition-strategy-shows-potent-synergy-with-regorafenib-and-metformin-in-tumor-cell-killing/ Paper DOI - https://doi.org/10.18632/oncotarget.28861 Correspondence to - Paul Dent - paul.dent@vcuhealth.org Abstract video - https://www.youtube.com/watch?v=lmX_c2e_-HY Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28861 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, macroautophagy, ER stress, aramchol, regorafenib, BID To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

Fatty liver and insulin resistance form a dangerous loop driving diabetes, dementia, and colon cancer. Learn what causes this cycle, what happens when it keeps running, and how diet, fasting, the Mediterranean diet, and targeted supplements can break it for good. FEATURED PRODUCT The Good Poops Protocol — combining Liver Boost, Gut Powder, and Berberine Plus — directly targets both sides of the fatty liver and insulin resistance loop discussed in this episode. Liver Boost supports your liver's ability to process fats and manage detoxification, Berberine Plus has been shown to improve insulin sensitivity and lower pro-inflammatory cytokines, and Gut Powder addresses the digestive consequences — bloating, constipation, and gut dysfunction — that compound when this loop goes unchecked. Together, these three work on the liver, the blood sugar, and the gut simultaneously, which is exactly what this episode makes clear you need.

Walking videos are everywhere — "walk 10,000 steps and melt belly fat." The conclusion is right: walking does reduce body fat. But the explanation is completely wrong. Your body compensates for ~80% of exercise calories. The real reason walking transforms metabolic health has almost nothing to do with calories burned. Here's the actual science. CHAPTERS: 0:00 - The walking myth: why calorie counting is wrong 0:52 - I'm Dr. Robert Lufkin — the actual mechanism 1:09 - Part 1: The calorie burn myth 1:24 - Pontzer's constrained energy model (Current Biology, 2016) 2:12 - Your body claws back 80% of exercise calories 2:51 - Constrained energy expenditure confirmed (2021 review) 3:36 - The body's compensation is actually the feature 3:42 - Part 2: The hormonal truth — insulin and GLUT4 4:05 - GLUT4: 100-fold glucose uptake without insulin 4:49 - AMPK: the molecular switch for fat oxidation 5:31 - AMPK activates autophagy via sestrins 6:05 - Part 3: Cortisol and visceral fat 6:18 - Visceral fat: the fat that kills 7:07 - Walking lowers cortisol (systematic review) 7:37 - Outdoor walking: 20–30 min for biggest cortisol drop 7:45 - Japanese walking study: visceral fat down, independent of calories 8:18 - Part 4: The post-meal walk 8:52 - 10-minute walk right after eating beats 30 minutes later 9:44 - Why the body's calorie compensation is a metabolic gift 10:36 - Part 5: The metabolic framework 11:04 - Walking is a hormonal intervention, not a calorie one 12:01 - Walking: 2 million years of metabolic medicine REFERENCES: Constrained Total Energy Expenditure (Pontzer et al., Current Biology, 2016): https://pubmed.ncbi.nlm.nih.gov/26832439/ 10-Min Walk Immediately After Meals Suppresses Glucose (Hashimoto et al., Scientific Reports, 2025): https://pubmed.ncbi.nlm.nih.gov/40594496/ Exercise, GLUT4, and Skeletal Muscle Glucose Uptake (Physiol Rev, 2013): https://pubmed.ncbi.nlm.nih.gov/23899560/ GLUT4 Translocation — 100-Fold Glucose Uptake (Am J Physiol, 2020): https://pmc.ncbi.nlm.nih.gov/articles/PMC8260367/ AMPK and Adaptation to Exercise (Annual Review of Physiology, 2022): https://pmc.ncbi.nlm.nih.gov/articles/PMC8919726/ Physical Activity Lowers Cortisol (Psychoneuroendocrinology, 2022): https://pubmed.ncbi.nlm.nih.gov/35777076/ Walking + Forest Environment Reduces Cortisol (Frontiers in Public Health, 2019): https://pmc.ncbi.nlm.nih.gov/articles/PMC6920124/ Daily WalkiNew episodes every Tuesday & Thursday. Subscribe so you don't miss one.Continue this conversation on Substack: https://robertlufkinmd.substack.comLies I Taught In Medical School — Free sample chapter: https://www.robertlufkinmd.com/lies/Web: https://www.robertlufkinmd.comYouTube: https://www.youtube.com/robertlufkinmdX: https://x.com/robertlufkinmdInstagram: https://www.instagram.com/robertlufkinmd/TikTok: https://www.tiktok.com/@robertlufkinLinkedIn: https://www.linkedin.com/in/robertlufkinmd/

If you feel like your metabolism has slowed down, your workouts aren't working, and your body isn't responding the way it used to… this episode explains why. In Part 3 of this series, we shift from identifying the problem to understanding the solution. Because your metabolism isn't broken. Your signals are disrupted. After years of chronic stress, underfueling, overtraining, poor recovery, and hormonal shifts in midlife, the body adapts by slowing down, conserving energy, and prioritizing survival over performance. In this episode, you'll learn how to restore the signals that control your metabolism—from the inside out. We break down: • Why energy availability is the foundation of metabolic recovery • The balance between AMPK (burn mode) and mTOR (build mode) • How nervous system regulation impacts fat loss, hormones, and recovery • Why breathing patterns and carbon dioxide tolerance affect energy production • The role of gut health, liver detox pathways, and inflammation in metabolism • How receptor sensitivity impacts hormone function and results • What true metabolic resilience looks like in midlife This is where you stop forcing your body… …and start rebuilding it. If you're ready to understand your metabolism on a deeper level and create a personalized strategy based on your data, this is exactly what we do inside The FutureYou Blueprint.

Are you great at burning fat—but struggling with recovery, muscle, energy, or stubborn body composition? In this Part 1 episode, Coach Debbie Potts takes you down a deep-dive rabbit hole into AMPK dominance, the "burn mode" many high performers and endurance athletes unknowingly live in. You'll learn how chronic stress, under-fueling, fasting, and excessive endurance training can shift your body into energy conservation instead of rebuilding—and why this becomes even more important in midlife. Debbie breaks down the difference between being a fat burner vs. metabolically flexible, and how PNOĒ metabolism testing reveals key clues at rest (RMR) and during exercise (AMR), including: • Low resting metabolic rate (RMR) and what it really means • Fat-burning dominance vs true metabolic flexibility • Poor high-intensity capacity and "flat" performance • Limited carbohydrate access when you need it most • Signs of chronic AMPK activation and reduced mTOR signaling This episode will help you understand why your body may feel stuck—even when you're doing everything "right"—and why the solution isn't more discipline, but better metabolic signaling and strategy. This is where you stop guessing… and start connecting the clues.

This week's stories: *SNL Roasts the MAHA Movement Saturday Night Live took direct aim at RFK-adjacent anti-vaccine culture in a sketch that lampoons raw milk, bull semen, energy healers, and "natural immunity" rhetoric — and it landed with a mainstream audience. Dave breaks down what it means when fringe health narratives become national punchlines, and why being a biohacker means staying precise about what you're actually skeptical of. Sources: -https://www.nbc.com/saturday-night-live -https://www.statnews.com/2026/03/03/fda-breakthrough-designation-generative-ai-chatbot-recovryai/ *Pistachios Are a Stealth Longevity Stack New Cornell-linked research shows pistachios are significantly more bioactive than standard nutrition data suggested — hitting Nrf2, AMPK, and gut barrier pathways simultaneously. This is a whole-food hack hiding in plain sight. Sources: -https://www.reddit.com/r/Biohackers/comments/1rvcqiy/cornell_university_reveals_pistachios_are_far/ -https://www.instagram.com/p/DViqesBDOZQ/ *40 Million People Are Using ChatGPT as Their Doctor Industry estimates put daily ChatGPT health queries at roughly 40 million users — making AI the largest informal primary care interface on the planet. Dave lays out the only safe framework for using these tools without getting burned. Sources: -https://www.linkedin.com/pulse/month-healthcare-ai-march-2026-gary-monk-ermcf -https://www.statnews.com/2026/03/03/fda-breakthrough-designation-generative-ai-chatbot-recovryai/ -https://bipartisanpolicy.org/issue-brief/fda-oversight-understanding-the-regulation-of-health-ai-tools/ *Your Microbiome Is a City — and Architecture Matters New biofilm research shows that how your gut microbes physically organize themselves may matter as much as which strains you have. The next frontier of microbiome hacking is infrastructure, not species. Sources: -https://phys.org/news/2026-01-hidden-microbial-communities-health-space.html -https://astrobiology.com/2026/03/rethinking-the-microbial-future-of-space-travel.html *Colon Cancer Is Now the Leading Cause of Cancer Death Under 50 This is no longer a retirement problem. Dave breaks down the four drivers behind the spike — and why your gut health protocols are now frontline cancer prevention. Sources: -https://pubmed.ncbi.nlm.nih.gov/41754195/ -https://www.washingtonpost.com/wellness/2026/03/03/muscle-strength-longevity-study/ *Measles Is Back — and the Math Is Unambiguous Over 1,300 confirmed cases across 31 states in 2026 alone, with the US at risk of losing its measles elimination status for the first time since 2000. Dave addresses the "natural immunity" argument directly — and doesn't pull punches. Sources: -https://www.cdc.gov/measles/cases-outbreaks.html -https://bipartisanpolicy.org/issue-brief/fda-oversight-understanding-the-regulation-of-health-ai-tools/ This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on immune resilience, gut health, microbiome optimization, cancer prevention, and how to use AI tools safely. Host Dave Asprey connects emerging science, cultural shifts, and real epidemiological data into practical frameworks you can use to build a resilient, adaptable health stack. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: MAHA movement biohacking, SNL vaccine sketch, RFK health satire, pistachios polyphenols longevity, pistachio Nrf2 AMPK, ChatGPT health advice AI, AI primary care risks, gut microbiome biofilm architecture, colon cancer under 50, colorectal cancer young adults, colon cancer prevention diet, measles outbreak 2026, measles elimination status, natural immunity measles risk, immune amnesia measles, biohacking news, longevity research 2026 Thank you to our sponsors! - Dave Asprey's 2026 Clean Nicotine Roadmap | Enroll for free at: daveasprey.com/2026-clean-nicotine-roadmap- The One Device | Use code DAVE for $10 off at theonedevice.com/dave Resources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 00:41 – SNL Roasts the MAHA Movement 03:20 – Pistachios and Longevity 04:37 – AI as Your Health Advisor 06:12 – Gut Biofilms and Microbiome Architecture 07:44 – Colon Cancer in Young People 09:23 – The Measles Comeback See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Biomechanist Katy Bowman and biologist Dr. Jeannette Loram explain how just nine minutes of vigorous activity can make a measurable difference for your cardiovascular health. They break down what counts as vigorous exercise, how to gauge it “old skool” without complicated gadgets, and how much is needed based on the movement patterns of the heart-healthy Hadza. Plus, they share nine practical ways to fit short bursts of higher-intensity movement into your day, from running stairs and kitchen dance parties to treading water in a pool.The episode also explores a personal experience related to the menopause transition, including the onset of salt sensitivity, water retention, and hypertension. Katy and Jeannette discuss the link between estrogen and salt management, explaining why the loss of estrogen can make women more susceptible to salt-induced high blood pressure—and what lifestyle shifts can help protect heart health.Enhanced Show Notes and Full Transcript00:00 — Introduction & Sponsors01:50 — Heart Health and Midlife Movement03:45 — What Counts as Vigorous Exercise?07:00 — How Much Vigorous Do We Actually Need? Insights from the Hadza 12:30 — Nine Minutes of Vigorous Movement: Practical Ideas to fit into your life25:00 — Listener Question: Vigorous Movement in the Pool36:20 — Warming Up for Vigorous Movement Snacks 41:30 — Salt Sensitivity, Menopause & Blood PressureLinks & Research Mentioned:Physical Activity Patterns and Biomarkers of Cardiovascular Disease Risk in Hunter Gatherers  by Raichlen et al (2017) Lifestyle and Patterns of Physical Activity in Hadza Foragers by Sayre et al (2023)Association of wearable device-measured vigorous intermittent lifestyle physical activity with mortality by Stamatakis et al (2022) Postmenopausal Salt Sensitivity and Hypertension by Kim et al (2014)Estrogen negatively regulates the renal epithelial sodium channel (ENaC) by promoting Derlin-1 expression and AMPK activation by Zhang et al (2019) Salt Sensitivity of Blood Pressure in Women by Barris et al (2023)Connect, Move & Learn:Join Our Newsletter: Movement Colored GlassesFollow Katy on SubstackTry Katy's Virtual Studio Free for 7 days!Made Possible By Our Wonderful Sponsors:Movemate: Active standing boards with smoothly articulating wooden slats. Designed to keep you moving without interrupting your focus.Peluva: Five-toe minimalist shoes that move like you do—take 10% off with code NUTRITIOUSMOVEMENTMy Happy Feet: Toe-spacing socks that gently realign toes for comfortable recovery—take 20% off with code MYDNA.Venn Design: Beautifully upholstered ball-shaped Air Chairs that encourage dynamic sitting.Ikaria Design: The Soul Seat® offers height-adjustable, multi-position sitting—get 10% off new chairs and desks with code DNA10.Smart Playrooms: Beautiful playroom design and movement-rich equipment—save 10% on monkey bars and rock-wall items with code DNA10.Thoughts/questions email us at podcast@nutritiousmovement.comYour Voice on the Podcast: Read The Credits 

Longevity science is shifting fast. New discoveries are revealing that aging may be influenced not just by genetics or lifestyle, but by specific nutrients that regulate cellular health. In this episode of Habits & Hustle, I sit down with Dr. Stephanie Venn-Watson to explore the discovery of C15, a fatty acid that emerged from decades of research studying Navy dolphins. Her work suggests that declining C15 levels may weaken cell membranes, accelerate aging, and increase vulnerability to metabolic disease. We break down how this molecule works, why not all saturated fats are the same, and how modern dietary shifts away from full-fat dairy may be contributing to widespread nutrient deficiencies. We also discuss how C15 interacts with longevity pathways like AMPK and mTOR, the same pathways targeted by drugs like metformin and rapamycin, and why researchers believe C15 may function as a geroprotector — a compound capable of slowing biological aging. Dr. Stephanie Venn-Watson is a veterinary epidemiologist, CEO of Seraphina Therapeutics, and author of The Longevity Nutrient. Her work bridges marine biology, epidemiology, and human longevity science to uncover how nutrition influences cellular aging. What's Discussed (07:48) How studying Navy dolphins led to a breakthrough in longevity research (10:31) Why dolphins are a powerful model for studying human aging (16:04) The discovery of C15 and its role in metabolic health (17:33) Why not all saturated fats are harmful (20:25) How C15 interacts with longevity pathways like mTOR and AMPK (22:23) How modern diets may be creating a widespread C15 deficiency (24:30) The link between C15 deficiency and accelerated cellular aging (27:11) How dairy fat became the primary source of C15 in humans (31:18) Why C15 may qualify as a “geroprotector” (34:28) How to measure C15 levels through blood testing (39:23) Signs of cellular fragility and biological aging in blood markers (43:02) How C15 may influence inflammation and autoimmune conditions (50:20) The lifestyle factors that matter most for longevity (55:17) Other ways to increase C15 levels through diet and exercise Thank you to our sponsors: Rho Nutrition: Try Rho Nutrition today and experience the difference of Liposomal Technology. Use code JEN20 for 20% OFF everything at https://rhonutrition.com/discount/jen20  Prolon: Get 30% off sitewide plus a $40 bonus gift when you subscribe to their 5-Day Program! Just visit https://prolonlife.com/JENNIFERCOHEN and use code JENNIFERCOHEN to claim your discount and your bonus gift. Therasage: Head over to therasage.com and use code Be Bold for 15% off  Air Doctor: Go to airdoctorpro.com and use promo code HUSTLE40 for up to $300 off and a 3-year warranty on air purifiers. Magic Mind: Head over to www.magicmind.com/jen and use code Jen at checkout. Momentous: Shop this link and use code Jen for 20% off  Manna Vitality: Visit mannavitality.com and use code JENNIFER20 for 20% off your order  Amp fit is the perfect balance of tech and training, designed for people who do it all and still want to feel strong doing it. Check it out at joinamp.com/jen   Find more from Jen:  Website: https://jennifercohen.com Instagram: @therealjencohen Books: https://jennifercohen.com/books Speaking: https://jennifercohen.com/speaking-engagement Find more from Stephanie Venn-Watson: Website: https://fatty15.com Instagram: https://www.instagram.com/fatty15/?hl=it  LinkedIn: https://www.linkedin.com/in/stephanievennwatson/ Book: The Longevity Nutrient

Is fasting actually worth it for fat loss, muscle retention, and longevity? In this science-backed breakdown, I explain intermittent fasting, autophagy, AMPK, mTOR, and whether fasting helps or hurts muscle growth. ► Free 7 Day Trial To My Workout App: https://www.liveleantv.com ► Live Lean Body Quiz: https://www.liveleantv.com/quiz ► Free 7 Day Meal Plan And Recipes: https://www.liveleantv.com/free-stuff

What should you actually do when you're chronically sleep deprived?If you're a parent, shift worker, insomniac, or coach people who are, you've probably asked yourself whether training is helping or harming you.In this episode, I dive into the research on acute and chronic sleep restriction and its effects on:• Cognitive performance• Strength and endurance• Hormonal signalling (testosterone, AMPK, mTOR)• Mood and perceived health• Recovery and long-term adaptationWe examine a 2025 systematic review and meta-analysis of 45 experimental studies (from 18,127 initially identified papers) looking at sleep deprivation and performance. We unpack one of the longest chronic sleep restriction protocols to date (6 weeks of restricted weekday sleep with weekend “recovery”), and what that tells us about cumulative sleep debt.We also explore:• Why early waking may impair cognition differently than going to bed late• Whether moderate aerobic exercise can offset some cognitive effects of sleep loss• What experimental data show about testosterone under sleep restriction• Why resistance training under chronic sleep deprivation may require adjustment• The difference between narrative reviews and higher-quality meta-analytic evidenceEssentially, we look at how to train intelligently when sleep is broken, short, or unpredictable, and what the science can (and cannot) tell us right now.Main ReferenceSystematic Review & Performance Effects[2025 Systematic Review & Meta-Analysis on Sleep Deprivation and Performance – 45 Experimental Studies]Chronic Sleep Restriction with Weekend RecoverySmith et al. (2021). Chronic sleep restriction during a 6-week protocol with weekend recovery and cumulative sleep debt analysis.

Sardines are one of the most nutrient-dense, anti-inflammatory foods you can eat, but does eating only sardines actually count as fasting?     On today's show, I break down the growing trend of "sardine fasting," explain why it's gaining popularity, and clarify the key differences between true fasting, fasting-mimicking diets, and simply following a low-calorie, high-protein plan.     You'll learn why sardines, while incredibly healthy, do not lower IGF-1 or activate AMPK, why that matters for longevity and autophagy, and when a sardine-only day may—or may not—make sense depending on your goals.     Join me on today's Cabral Concept, Episode 3646, to find out whether the sardine fasting diet really works and what you can do instead to achieve better results.     Enjoy the show! - - - For Everything Mentioned In Today's Show: StephenCabral.com/3646 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

Why do we lose ourselves in love, repeat painful relationship patterns, and mistake intensity for intimacy instead of becoming whole within ourselves first?Josh Trent welcomes Sheleana Aiyana to the Wellness + Wisdom Podcast, episode 800, to explore why self-abandonment drives relationship chaos, how attachment wounds and the mother wound shape romantic bonds, what becoming the one truly means, how grief and motherhood catalyze deep healing, and why divine union begins with reclaiming self-trust, presence, and inner wholeness before partnership.In This Episode, Sheleana Aiyana Uncovers:(01:15) Why We Lose Ourselves In Relationships(06:40) Your Soul Came Here to Learn(11:10) Becoming The One(16:10) Awakening Through Relationships(20:50) Mother Wound(25:45) True Depth of Transformation + Healing(32:10) When Motherhood Reopens It Heals Your Wounds(38:55) What Is The Role of A Parent?(46:55) Life Feels Heavy When You Abandon Yourself(53:45) Relationship Rebirth(01:03:05) What Is A Divine Union?

Why do we lose ourselves in love, repeat painful relationship patterns, and mistake intensity for intimacy instead of becoming whole within ourselves first? Josh Trent welcomes Sheleana Aiyana to the Wellness + Wisdom Podcast, episode 800, to explore why self-abandonment drives relationship chaos, how attachment wounds and the mother wound shape romantic bonds, what becoming the one truly means, how grief and motherhood catalyze deep healing, and why divine union begins with reclaiming self-trust, presence, and inner wholeness before partnership.   About The Guest Sheleana Aiyana is the best-selling author of Becoming the One and the founder of Rising Woman, a global community dedicated to self-healing, relational transformation, and spiritual embodiment. Her work blends somatic awareness, inner child healing, and grounded spiritual insight to guide millions through the landscapes of heartbreak, love, and personal rebirth. Having grown up in foster care and overcome cycles of abuse, addiction, and heartbreak, Sheleana's teachings are not theoretical, they are lived. Through Rising Woman, she has helped millions remember that healing is not about becoming someone else, but about reclaiming the love, power, and wholeness that was always theirs.

Tired of doing “everything right” and still feeling inflamed, foggy, and out of sync with your body? We dig into a clear, faith-forward plan to restore energy, steady hormones, and heal the gut using targeted, physician-grade supplements and practical daily habits. No fads. No hype. Just clean science, smart dosing, and tools you can actually stick with.We start by reframing the problem: modern food and stress deplete minerals, overwhelm the liver, and skew our fat balance. That's why stacked support works best. We unpack Hormone Tame as a five-in-one: activated B vitamins for methylation, mitochondrial nutrients for energy, and polyphenols that help metabolize estrogen so periods calm and mood steadies. Then we tackle the omega equation—why seed oils drive inflammation and how a high-purity omega-3, plus magnesium, can flip the script on aches, sleep, and resilience.From there, we build your gut plan. A medical-food style protein with L-glutamine soothes IBS and feeds the lining. Digestive Lift adds enzymes, gentle acid, and ox bile to prevent bloat and help you handle healthy fats. For microbiome balance, Biome Lift stabilizes daily while Spore Lift acts like a bouncer when SIBO or post-travel trouble hits. We also introduce a fiber you won't fear: a diverse prebiotic blend that increases short-chain fatty acids, nudges Akkermansia for metabolic health, and naturally boosts GLP-1 to curb cravings.Detox gets a reset with a true 3-2-1 approach—opening phase 3 and 2 before phase 1 so toxins exit rather than recirculate. Expect less bloat, brighter skin, and steadier energy when you rotate this seasonally and keep daily support with Slim Lift. If you're stepping down from GLP-1 meds or want a stimulant-free metabolism boost, MetaboLift pairs GLP-1 support with AMPK activation to quiet “food noise” and raise your burn without wrecking appetite or sleep.This is how faith, functional medicine, and simple choices meet: whole foods, better fats, prayer, rest, and supplements that respect how the body actually works. Subscribe, share with a friend who needs hope, and leave a review to help more women find real healing.✨ Join the EMPOWERED BY FAITH: 5 Days To A Lighter You Challenge!

Sardines are one of the most nutrient-dense, anti-inflammatory foods you can eat, but does eating only sardines actually count as fasting?     On today's show, I break down the growing trend of "sardine fasting," explain why it's gaining popularity, and clarify the key differences between true fasting, fasting-mimicking diets, and simply following a low-calorie, high-protein plan.     You'll learn why sardines, while incredibly healthy, do not lower IGF-1 or activate AMPK, why that matters for longevity and autophagy, and when a sardine-only day may—or may not—make sense depending on your goals.     Join me on today's Cabral Concept, Episode 3646, to find out whether the sardine fasting diet really works and what you can do instead to achieve better results.     Enjoy the show! - - - For Everything Mentioned In Today's Show: StephenCabral.com/3646 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

What if the biggest metabolism disruptor today is not carbs or calories, but the toxic load you cannot see? In this episode of the Metabolic Freedom Podcast, Ben Azadi sits down with Mara Labs co-founders David Roberts and Dr. John Gildea for a deep dive into microplastics, detox pathways, and the science of sulforaphane. They break down how microplastics and the chemicals that leach from plastics can interfere with cellular function, including lysosomes, autophagy, inflammation, and hormone signaling. You will learn why sulforaphane is known for activating Nrf2, what that means for detox and repair genes, and why the conversation around metabolic health is also a conversation about toxin exposure. They also discuss berberine as a tool for metabolic flexibility, blood sugar support, ketosis, and even sleep, plus new product innovations like BarkElite for dogs. If you want practical strategies backed by research and real-world testing, this one is packed. Key Topics Covered Why microplastics are everywhere and why that matters for metabolism and longevity How microplastics may interfere with lysosomes, autophagy, and cellular cleanup What sulforaphane is and how it activates the Nrf2 pathway Phase 1, 2, and 3 detox explained in plain English Why inflammation is often the real root issue behind stubborn fat loss Berberine, AMPK, GLP-1 signaling, and metabolic flexibility Why late-night eating can wreck sleep and HRV The dog angle: joint support, inflammation, and BarkElite Coupon and Discount  Browse all products featured in this episode : http://www.benazadi.com/mara Mara Labs discount code: FREEDOM 25% off from January 19, 2026 through January 26, 2026 After January 26, 2026: code still works for 15% off Follow Ben Azadi