Podcasts about Peak

Linktree: ⁠https://linktr.ee/Analytic⁠Join The Normandy For Additional Bonus Audio And Visual Content For All Things Nme+! Join Here: ⁠https://ow.ly/msoH50WCu0K⁠Analytic Dreamz dives into Borderlands 4's chaotic September 12, 2025, release by Gearbox Software and 2K Games on PS5, Xbox Series X/S, and PC via Steam/Epic—Switch 2 port hits October 3. Set on dystopian Kairos, this darker "soft reboot" trades Borderlands 3's memes for grounded resistance vibes, boasting 20-25 hour main story, 50-60 with sides, and 120-170 completionist runs. Sales exploded: 1M+ on Steam in days, another 1M+ consoles pre-Switch, 5M units in 48 hours (franchise-fastest), pushing lifetime totals past 100M ($150M+ revenue). Peak concurrents hit 304,398 (#46 Steam all-time), outpacing Hollow Knight: Silksong's 587,150 but at $70 vs. $20.Critics laud Metacritic 84/PC and OpenCritic 85 ("Mighty" top 7%) for exhilarating gunplay, loot depth, seamless open world (no loading zones), and co-op—IGN 8/10, GameSpot 7/10 praise mobility like double-jumps, grappling, and hybrid "Licensed Parts" weapons blending 8 manufacturers. Bosses demand 10+ minute multi-phase mechanics, not sponges. But "Stutterlands 4" memes rage over Unreal Engine 5 woes: PC stuttering, RTX 4090 FPS drops, crashes, memory leaks; consoles locked at 70° FOV, no motion blur toggle. Day 1 patch helped, but corrupted saves, UI glitches persist—Steam reviews "Mixed."Controversies fuel toxicity: Pre-launch EULA "spyware" rumors (debunked), Pitchford's "$80 real fans" tweet sparking piracy threats, $130 Super Deluxe skimping DLC vs. BL3's $100 Ultimate. Post-launch, Pitchford's "build your own engine" clapback ignited review-bombs. Community splits on Reddit/X: Co-op bliss and Easter eggs (Noisy Cricket, bobbleheads) vs. bland villain, pricing gripes. Analytic Dreamz unpacks if patches salvage this loot-shooter gem amid franchise highs and dev drama—tune in for the full fallout.Support this podcast at — https://redcircle.com/analytic-dreamz-notorious-mass-effect/donationsAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

Summer is almost officially over, and while some Oregonians may be eagerly transitioning into fall, there's still time to get in your final few summer activities. On this week's episode of Peak Northwest, we go over 10 of the best ways to round out an Oregon summer, making sure you make the most of the last days of the season. While many are oriented around water – hanging out by a river, taking a trip to the coast – there are so many other ways to enjoy the warm, sunny season while it lasts. So before you hang up your swimsuit for your flannel, make sure to get in a couple more summer activities for good measure. Here are some highlights from this week's show: Sugarpine Drive-In combines two great Oregon summer pastimes. Why late summer is the best time to get into the mountains. This might be the perfect time for a road trip across eastern Oregon. Caves are often associated with the spooky season, but summertime is the best time to get underground. Learn more about your ad choices. Visit megaphone.fm/adchoices

In Episode 85 of the GHM Podcast, we talk about the NEW Demon Slayer Infinity Castle Movie and how PEAK it was, some of the new anime that just finished up, and we play Headbandz Naruto Edition!

Does anyone else hear that low buzzing sound when the residents of Mineral Town talk? Or are my ears still ringing from my last encounter with Mayor Felix? Time will tell, I suppose.Discussed: We're both sick, Story of Seasons: Grand Bazaar, what makes communities in games feel alive, games about being a shopkeeper, Neopets, Mayor Felix, PEAK, Friendslop, the secret microphone  within the Steam Deck, the word “marvel”, Silksong, intrinsic motivation, Hades II on the horizon, a new Fire Emblem, Nine Sols, parrying and stealth missions, Bake Off sketches, and lunchtimeFind us everywhere: https://intothecast.onlineBuy some merch if you'd like: https://shop.intothecast.onlineJoin the Patreon: https://www.patreon.com/intothecast---Follow Stephen Hilger: https://bsky.app/profile/stephenhilger.bsky.social Follow Brendon Bigley: https://bsky.app/profile/bb.wavelengths.onlineProduced by AJ Fillari: https://bsky.app/profile/ajfillari.bsky.social---Season 8 cover art by Scout Wilkinson: https://scoutwilkinson.myportfolio.com/Theme song by Will LaPorte: https://ghostdown.online/---Timecodes:(00:00) - Intro (01:35) - Story of Seasons: Grand Bazaar | Enough talk about SNOT (24:43) - Break (24:45) - Dayquil and water (26:23) - PEAK | This game is real (43:32) - Break (43:34) - Silksong | Fueled by a big cuppa boba tea (01:12:37) - Nine Sols | Stop this lunacy (playing soulslikes)! (01:31:10) - Wrapping up ---Thanks to all of our amazing patrons, including our Eternal Gratitude members:SnzznBertitoJ-RockGregory Mark SCmndr BiscuiticemanChristian HRydan BCaleb HArden FEye of the DuckKaleNathan EJ. H. AjoelchronoMellowMatthew BRobin LPSeekingSeakingJimmerszoey!Vinny MMattKerry KBrian MNoah DZach DChristopher TDHugo WToddChris BLukerfuffleStephen YDaniel GEric FTaran WBrendan OChris ZClayton MZach RGriffinDylan NFederico VTigerz RevengeLogan HAlan RJohn AMike LmattjanzzDavid MHeavyPixelsKaleb HTyler JCorey ZSusan HBarry TRobert RChris JBrett Allen HDan SJack SGarrett CjimiiboJohn HDirch FJim EJim WTristan LEvan BAwfulHanzomin2Aaron GJean HTodd Nred_wagonNeilPeter BJohn VvErik MRedmage77Joshua JTony LDanny KGibson GKate Duncan BRichard MDaniel NSeth MJamesAndy HDemoEmmaLyn ECorey TCaleb WJake LJesse WMike TCodesMatt BWesleymebezacAlex LSergio LninjadeathdogRory BA42PoundMooseRobert MMichael WAndrewthis_JUSTINRyan O14.3 billion yearsBrendan KMegan BSecretAgentKoalaNoah OArcturusAndrew WhepaheChase ALoveDiesNick QChris MRBKaren HAdam FScott HAlexander SMatt HMurrayDavid PJason KMicah OKamrin HAndrew DKyle SPhilip N ★ Support this podcast on Patreon ★

Kylian Mbappé delivered a brace in yesterday's opening match in the UEFA Champions League competition for his club. It was enough to put them over the top in the 2-1 victory. It was also the club's 700th UCL goal, 200th, UCL win. Mbappé now has 57 goals in the competition and it was Xabi Alonso's first UCL victory as well. Morning Footy is available for free on the Audacy app as well as Apple Podcasts, Spotify and wherever else you listen to podcasts.  Visit the ⁠⁠⁠⁠⁠betting arena on CBSSports.com⁠⁠⁠⁠⁠ for all the latest in ⁠⁠⁠⁠⁠sportsbook reviews⁠⁠⁠⁠⁠ and ⁠⁠⁠⁠⁠sportsbook promos⁠⁠⁠⁠⁠ for ⁠⁠⁠⁠⁠betting on soccer⁠⁠⁠⁠⁠ For more soccer coverage from CBS Sports, visit ⁠⁠⁠⁠⁠https://www.cbssports.com/soccer/⁠⁠⁠⁠⁠ To hear more from the CBS Sports Podcast Network, visit ⁠⁠⁠⁠⁠https://www.cbssports.com/podcasts/⁠⁠⁠⁠⁠ Watch UEFA Champions League, UEFA Europa League, UEFA Europa Conference League, Serie A, Coppa Italia, EFL, NWSL, Scottish Premiership, Argentine Primera División by subscribing Paramount Plus: ⁠⁠⁠⁠⁠https://www.paramountplus.com/home/⁠⁠⁠⁠⁠ Visit the betting arena on CBS Sports.com: ⁠⁠⁠⁠⁠https://www.cbssports.com/betting/⁠⁠⁠⁠⁠ For all the latest in sportsbook reviews: ⁠⁠⁠⁠⁠https://www.cbssports.com/betting/sportsbooks/⁠⁠⁠⁠⁠ And sportsbook promos: ⁠⁠⁠⁠⁠https://www.cbssports.com/betting/promos/⁠⁠⁠⁠⁠ For betting on soccer: ⁠⁠⁠⁠⁠https://www.cbssports.com/betting/soccer/ To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

This weeks crew: Webby, Darren, Nick, Graham We discuss Darren having a fall and is now out of gaming action for a while. Games discussed include Hell is Us, F1 25, GT7, Helldivers 2, Cronos, Car X Street, Peak, Into Black, Goldeneye, Mafia Old Country, Donkey Kong, and more. In the news we discuss the Nintendo Direct with some strange announcements including a Virtual Boy peripheral and Charlie Kirk's brutal assassination. https://www.patreon.com/360gamercast https://discord.gg/CqDMSg9 https://www.facebook.com/groups/360gamercast/ https://twitter.com/Webby360G https://twitter.com/360GamerCast All Access Patrons - John Smith Philip Thompson

Carrie and Molly continue their trek through the Glacier Peak Wilderness, taking a pit stop at one of their favorite spots along the Pacific Crest trail. They make a decision on carrying water and descend through thickets and blow down on their way to Milk Creek. They encounter hiker who finds himself in a complex situation. They discuss PCT trail conditions this season in the Glacier Peak wilderness. Carrie reveals her “crazy girl delulu dream.” The sisters make an exciting discovery at camp.

Believe it or not, peak rut dates across the whitetail's range stretch all the way from July to February — an incredible span of eight months. But when is the peak of the rut where YOU hunt? Big-game biologists Brian Murphy and Jim Heffelfinger from HuntStand join us to discuss how they compiled breeding data from across North America to map peak whitetail breeding dates across more than 5,000 counties and parishes, along with peak breeding dates for mule deer, blacktail deer and elk.

In this special episode of The Produce Industry Podcast, host Patrick Kelly travels to Winnipeg, Manitoba to meet with Pamela Kolochuk, CEO of Peak of the Market. Join Patrick on this Canadian adventure as he sits down with Pamela to discuss the heart of the produce industry in Manitoba, the unique challenges and opportunities of farming in the region, and how Peak of the Market continues to innovate while staying rooted in community and sustainability.

Do you feel like your days slip away before you ever get into a state of true focus? The problem might not be time—it's energy.In this episode of Productivity MD, we dive into the concept of energy arbitrage—mastering your chronotype, aligning your day to your natural rhythms, and using intentional flow blocks to get more done with less struggle.You'll learn how to identify your personal peak zones, build two daily flow blocks, and even optimize what you eat to sustain deep focus. By the end, you'll have a roadmap to hit your goals while still making time for yourself.Key Points From This Episode:How to determine your chronotype and why it mattersStructuring your day around energy—not just tasksAction steps that bring you closer to your goalsWhy starting with time for yourself sets the tone for focusLeveraging your second flow block during peak energy zonesThe different types of peak zones and their timingWhy two flow blocks a day can transform productivityThe role of nutrition in sustaining focus and energyListen to the previous episodes hereWelcome to Productivity MD where you can learn to master your time and achieve the 5 freedoms in life!Show Notes - Are You Wasting Your Peak Energy Time on Low Value Tasks? Find Your Chronotype Peak Zone and 4X Your ProductivityPlease subscribe and leave a review so you can help others who need the knowledge most discover this podcast. Visit https://www.productivitymd.com/ to learn more Here are 3 ways I can help you reclaim your time and be more productive:#1: Book a 15 minutes 1 Year 1-1 Peak Performance and Productivity Coaching Qualification Call now to learn more and take control of your time! #2: Join my Private Facebook Group and get full access to my 7-day Video Masterclass to 3X Your Productivity#3: Subscribe to Productivity MD Podcast (Formerly It's Not Rocket Science) on Health, Relationships, and Productivity or watch in YouTube.Follow Ann Tsung MD, MPH onAnn Tsung on FacebookAnn Tsung on YouTubeAnn Tsung on LinkedInAnn Tsung on InstagramAnn Tsung on Twitterhttps://www.productivitymd.com/2025/09/15/episode-78/

Certified trainer and nutrition coach Dan Vaysburd joins Rich to share his road from early addictions—starting with video games—to substance use, relapse, and finally sustained recovery anchored in strength training and sustainable nutrition. He explains why “diets” fail, how counting macros and consistency changed his life, and why fitness paired with fellowship accelerates healing. This candid, practical conversation shows how to trade short-term highs for long-term health.Guest Bio:  Dan Vaysburd is a Los Angeles–based certified personal trainer and nutrition coach who left a high-stress finance career to pursue his passion for helping people get strong the sustainable way. An immigrant raised in New Jersey, Dan's recovery began in 2024; he now sponsors others in 12-step programs, coaches clients in person (and selectively online), and advocates pairing fitness with recovery as a powerful path to purpose. Main Topics: ·         Early addiction roots: isolation, video games, and identity (age ~7)·         Escalation after his mother's death; marijuana → alcohol → party drugs·         Peak addiction years in New York; returning to LA and starting recovery·         The relapse at a music festival and getting back on track (May 2024 milestone)·         Why diets don't work: sustainability vs. restriction; tracking calories & macros·         Strength training as a “lifeline” and cornerstone for sobriety·         Coaching in commercial gyms, management track, and part-time work at a detox center·         Bringing recovery and fitness to schools and athletes (speaking vision)·         Living amends: being present for family; purpose-driven routines  Resources mentioned: ·         Dan's website & socials (as stated on-air): “danvaysburd.com”; Instagram: “@dan.vaysburd” ·         Recovery fellowships referenced: AA, NA (12-step) ·         Supporter: Real Life Prosthetics·         Supporter: Full Circle Boards·         Supporter: Sincerely Sawyer Photography Send us a textDonate HereSupport the showRate & Review on Apple Podcasts Follow the Conversations with Rich Bennett podcast on Social Media:Facebook – Conversations with Rich Bennett Facebook Group (Join the conversation) – Conversations with Rich Bennett podcast group | FacebookTwitter – Conversations with Rich Bennett Instagram – @conversationswithrichbennettTikTok – CWRB (@conversationsrichbennett) | TikTok Sponsors, Affiliates, and ways we pay the bills:Hosted on BuzzsproutSquadCast Subscribe by Email

Peak week in marathon training is the week of your greatest volume and longest long run. It's also the week many runners fear or dread as months of training fatigue and doubts about your race set in. In this episode of Coach Quip, we have 5 tips to help you nail your peak week training to build confidence and fitness for race day.

The Baltimore Ravens turn it around and secure their first win of the season in Week 2 against the Cleveland Browns. The Ravens home opener and celebration of their 30 years in Baltimore was a joyous occasion, at the expense of former Raven and Baltimore legend, Joe Flacco. Baltimore's current quarterback is setting a new high bar himself. #nfl #ravensflock #baltimoreravens #clevelandbrowns Join us in YouTube Membership: https://www.youtube.com/c/410SportsTalk Follow us on social media: Instagram: @410sportstalk X (Twitter): @410_sportstalk Check out our merch: https://410-sports-talk.creator-spring.com/ Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Ever felt super confident when starting something new, only to hit a wall? That's the Dunning Kruger Effect!  Understanding this psychological phenomenon can provide clarity on why you might feel confused or frustrated while running your MFR business and selling your services. Tune in as Heather breaks down the four stages of the Dunning Kruger curve: the Peak of Mount Stupid, the Valley of Despair, the Slope of Enlightenment, and the Plateau of Sustainability. She explains how new MFR therapists often feel overconfident at first, only to face a reality check as they realize the complexities of their practice. With the right support and skills, you can navigate through these stages, ultimately reaching a place of mastery where confidence aligns with competence.   LINKS AND RESOURCES —

Stories WAMU is following this week include the D.C. Council taking its final vote redeveloping the RFK Stadium site, the start of early voting in the Virginia General Election and a look at the uniquely Mid-Atlantic paw-paw season.

Illinois Peak by Wild Montana

Soil preparation is the foundation of a productive garden. Especially in the desert Southwest. Agriscaping.com's Justin Rohner talks about avoiding common mistakes, food for the soil with organic matter and more tips for peak garden production. Original broadcast archive page with expanded content https://rosieonthehouse.com/podcast/outdoor-living-hour-ultimate-garden-hour-and-soilprep4peakproduction-with-justin-rohner-of-agriscaping/

Apple's yearly iPhone event took place this week, and it left us asking, Is Apple losing the juice? We break down all the new products the company announced and discuss where it goes from here. Then, Eliezer Yudkowsky, one of the most fascinating people in A.I., has a new book coming out: “If Anyone Builds It, Everyone Dies.” He joins us to make the case for why A.I. development should be shut down now, long before we reach superintelligence, and how he thinks that could happen.Guests:Eliezer Yudkowsky, founder of Machine Intelligence Research Institute and a co-author of “If Anyone Builds It, Everyone Dies”Additional Reading: A.I.'s Prophet of Doom Wants to Shut It All DownAI as Normal Technology, revisitedApple's misunderstood crossbody iPhone strap might be the best I've seen We want to hear from you. Email us at hardfork@nytimes.com. Find “Hard Fork” on YouTube and TikTok. Unlock full access to New York Times podcasts and explore everything from politics to pop culture. Subscribe today at nytimes.com/podcasts or on Apple Podcasts and Spotify.

In this episode of Elk Talk Podcast, Randy interviews Corey to cover the most effective tactics for the 2025 archery season. This podcast covers September 15-21, what we define as the start of the Peak Rut Season, accounting for moon phase (new moon), even more hunting pressure, location of bulls in relation to cows with older bulls now controlling the herds, best calling tactics for bulls at this time of the season, how to use water as a tool, and many other ideas to consider at you hunt bulls during this Peak Rut Season period. Learn more about your ad choices. Visit megaphone.fm/adchoices

What if the advice you've been following is part of the problem? In this episode of The Health Feast, I'm joined by Dr. Colin Zhu, DO, FACLM, Chef, aka The Chef Doc — a physician, chef, and board member of the American College of Lifestyle Medicine — to explore why so many people feel lost, even when they're trying to do everything “right.” Dr. Zhu's unique background in both culinary arts and clinical medicine brings a fresh perspective to what real healing requires — and why food is more than just fuel. It's identity. It's connection. It's power. Key Topics We Cover: Why our healthcare system focuses on managing disease, not creating health The food–body–community connection, and why it matters more than ever How Colin's journey through culinary school changed his approach to medicine Reframing food from restriction and fear to creativity and joy The ripple effect of our daily choices — personally and planetarily How to reclaim agency and start building health on your terms We also talk about his passion for blending creativity and health — including his recent appearance in the lifestyle medicine anthem, We Living Healthy, a joyful music video celebrating movement, community, and taking charge of your well-being. Whether you're plant-based, curious about lifestyle medicine, or just looking for a more grounded path to wellness — this episode will give you both inspiration and tools to move forward. Resources + Links: Learn more about Dr. Colin Zhu: https://www.thechefdoc.co/ Follow Colin on Instagram: @thechefdoc Listen to Colin's podcast Thrive Bites: wherever you get your podcasts or visit https://www.thechefdoc.co/thrive-bites-podcast Preorder Colin's new book (coming in 2026) Empowered Kitchen: https://publishizer.com/empowered-kitchen/ And if you found this valuable — share it with a friend, subscribe, or leave a review. Live well and RAK ON, Dr. Rak

What Is The Peak?

DJ and Producer of the infamous 2025 summer track 'front 2 back' Jordan Peak provides us with his 'Destination Dancefloor' Mini Mix

This week on Till the Dirt, Tommy and MJ dive into the whirlwind of life: MJ's infamous Instagram comment, prepping for her trip to San Jose while Tommy heads to Vegas, and Darth Vida panicking over… everything. Plus, there's some exciting potential news for Peak 7, and MJ is powering through F45 while double-fisting. Laughs, real talk, and all the behind-the-scenes antics you love! Till the Dirt Merch is here! Espresso shop.tillthedirtpodcast.com The Best Hug in The World, written by Tommy Feight    The Till the Dirt Patreon is LIVE! https://www.patreon.com/tillthedirt?utm_campaign=creatorshare_fan   Hey Dirties, do you want to be featured on the pod? DM us at @tillthedirtpodcast on Instagram for a chance to have your question answered by Tommy and MJ. Hey Dirties, do you want a personalized video from MJ or Tommy?! Check out their cameo links below: https://www.cameo.com/mercedesjavid https://www.cameo.com/tfeightnyc   If you would like to donate, send books or pick books from Tommy's Amazon wish list visit https://feightclub.com Learn more about your ad choices. Visit megaphone.fm/adchoices

✨Taiki works with founders in the VC world to build authentic companies. In this conversation we shift that focus inward, as he discusses how to build an authentic life beyond social media metrics ✨Follow Taiki: https://www.linkedin.com/in/taikichung/ My main channel: https://www.youtube.com/wamyy5

It's time once again for our Best of the Midwest feature! Are you trying to come up with some vacation ideas that are only a quick getaway from the Chicago area? Well, John Williams has some great recommendations for your trip! Today, we take a trip east to beautiful Ohio and visit with Karen Raymore, […]

It's time once again for our Best of the Midwest feature! Are you trying to come up with some vacation ideas that are only a quick getaway from the Chicago area? Well, John Williams has some great recommendations for your trip! Today, we take a trip east to beautiful Ohio and visit with Karen Raymore, […]

It's time once again for our Best of the Midwest feature! Are you trying to come up with some vacation ideas that are only a quick getaway from the Chicago area? Well, John Williams has some great recommendations for your trip! Today, we take a trip east to beautiful Ohio and visit with Karen Raymore, […]

It happened, the guys have witnessed real actual football and they can't wait to talk about it! Welcome to 5 Yard Rush NFL Podcast's first annual Week 1's Weak 1's & Peak 1's!Come and join the Discord here and chat all things NFL, Fantasy and College Football: https://discord.gg/zdzFsAW4Join the movement: https://www.patreon.com/c/5yardrushFollow us on X: https://x.com/5yardrush?s=21&t=8_S7HfEbtEZsXpKKar4NkgFollow us on BlueSky: https://bsky.app/profile/5yardrush.bsky.social Hosted on Acast. See acast.com/privacy for more information.

We should not be releasing games in 2025 without key features.

09-09-25 - New Disease Fear Is Screw Worms Infecting Us As We Wonder How Many Chickens There Are - Rant Against Man Who Plays His Pan Flute On Top Of Piestewa Peak - US School Test Scores Are Low Prompting John To Call Again For Teachers To QuitSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Bobby tried Void Crew, and it left a Pulsar Lost Colony shaped hole in his hull. Amanda and fiancée (newly announced!) are looking to survive the trumpets of Peak, and Christian thinks blue characters are ubiquitous in Sci-Fi? (they're clearly... not) Adding a whole convention worth of games to your backlog this episode! ADD THESE TO YOUR BACKLOG Mass Effect Legendary Collection, Void Crew, Peak OTHER TOPICS Bubsy in: The Purrfect Collection, Battlestar Galactica: Scattered Hopes HONORABLE MENTIONS FROM PAX Dumpster Divers, Cornucopia, Memoria Wake, Spellfarers, Wild Woods, Demonschool, Unsent , Hell Clock, Conquest Dark, The Rabbit Haul Check us out at dlgaming.net, and next week Amanda talks more finds at PAX such as the beloved MTG killer Gudnak that you can play on Tabletop Simulator now! Learn more about your ad choices. Visit megaphone.fm/adchoices

Carrie and Molly embark on a big day traveling through the glacier peak wilderness on the pacific crest trail. They cross Kennedy creek's glacial flow, muse over suspicions about Travis Decker, and meet challenges along the trail. The sisters discuss mindset during big climbs. Fire creek pass brings beautiful views and the sisters discuss the rugged terrain in this area of Washington.

09-09-25 - New Disease Fear Is Screw Worms Infecting Us As We Wonder How Many Chickens There Are - Rant Against Man Who Plays His Pan Flute On Top Of Piestewa Peak - US School Test Scores Are Low Prompting John To Call Again For Teachers To QuitSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

The US Open 2025 is over and the Champions have been crowned, Carlos Alcaraz and Aryna Sabalenka! It all happened in New York, from Polish CEO Piotr Szczerek stealing a hat from a child and making global headlines to Naomi Osaka turning up with blinged out Labubu's for every match. We also saw Taylor Townsend make headlines for all the right reasons and Jelena Ostapenko for all the wrong reasons as well as Novak Djokovic making it to four semifinals at majors this year! So as is tradition after two weeks of daily coverage, the Tennis Weekly team reunites in truly global fashion across three time zones (Spain, Greece, and the UK!) for a special US Open wrap-up episode. In this bonus pod, Joel, Kim, and Chris reflect on their own personal highs, lows, and biggest surprises from Flushing Meadows using their Peak, Pit & Pleasant Surprise scorecard. From jaw-dropping comebacks and unexpected breakthroughs and some shocking fashion faux-pas (or should that be haircuts), we cover it all.We also debate have our Tennis weekly awards to dish out for our own Best matches of the tournament, Biggest upsets, Who has the most room for improvement and our 2026 Australian Open “ones to watch”. Let us know who you think should win in these hotly contested categories and what your own favourite moments from the US Open were!SOCIALSFollow us on Twitter, Instagram, TikTok and YouTube, plus email the show tennisweeklypod@gmail.com.MERCHPurchase Tennis Weekly Merch through our Etsy store including limited edition designs by Krippa Design where all proceeds go towards the podcast so we can keep doing what we do!REVIEWS***Please take a moment to rate and review the show on Apple Podcasts, Spotify or wherever you get your pods. It really means a lot to us at HQ and helps make it easier for new listeners to discover us. Thanks!*** Hosted on Acast. See acast.com/privacy for more information.

Last time we spoke about the Japanese encirclement of Nanjing. As battles erupted around Lake Tai, the Chinese troops used guerrilla tactics and artillery to resist the technologically superior Japanese. However, internal strife and logistical issues began to weaken their defense. On December 1st, Japan's Central China Area Army was ordered to assault Nanjing, and despite heavy resistance, the Japanese forces swiftly captured key towns. By December 7th, with Japanese troops closing in, Chiang Kai-Shek prepared to evacuate the capital. Anxiety and fear gripped the city as civilians witnessed horrific atrocities in the countryside, where Japanese soldiers unleashed violence against unarmed populations. The defense of Nanjing became symbolic of Chinese perseverance against oppression. As the city faced inevitable destruction, hope rested on the courage of its defenders and the belief that they could rally against the relentless tide of attack, knowing their plight was drawing the world's attention amidst a brutal conflict.   #166 Enemy at the Gates of Nanjing  Welcome to the Fall and Rise of China Podcast, I am your dutiful host Craig Watson. But, before we start I want to also remind you this podcast is only made possible through the efforts of Kings and Generals over at Youtube. Perhaps you want to learn more about the history of Asia? Kings and Generals have an assortment of episodes on history of asia and much more  so go give them a look over on Youtube. So please subscribe to Kings and Generals over at Youtube and to continue helping us produce this content please check out www.patreon.com/kingsandgenerals. If you are still hungry for some more history related content, over on my channel, the Pacific War Channel where I cover the history of China and Japan from the 19th century until the end of the Pacific War. War was steadily creeping toward Nanjing, and the remaining residents understood this grim reality. Starting December 8, the distant sounds of artillery began to echo through the city. The following day, the first shell from a Japanese battery struck downtown, detonating at Xinjiekou square. Amid the chaos and anarchy engulfing much of Nanjing as the population dwindled, looting became rampant. Chinese soldiers were reportedly seen stealing from abandoned stores. Daily life had largely ground to a halt. To this desolate and partially lawless city, refugees from the war continued to arrive. However, on December 8, the influx of refugees came to an abrupt halt. All gates in the city wall were locked, only to be opened for urgent military needs. Even soldiers injured in battles near the city were reportedly denied entry, left to perish just minutes away from desperately needed medical care. As the Japanese forces tightened their grip around Nanjing, more civilians sought refuge in the safety zone. American missionary Ernest Forster wrote in a letter to his wife “I wish you could witness the influx of people into this area from other parts of the city. All the roads leading here are lined with groups transporting whatever possessions they can carry, tireless rickshaws, some even pulled by students, wheelbarrows, trucks, baby carriages, anything with wheels.” On the evening of December 7, bonfires lit by soldiers of Japan's 16th Infantry Division near Unicorn Gate were clearly visible from Purple Mountain, which was defended by the elite Training Division of the Chinese Army. The bonfires presented an enticing target for this division, established as a model to inspire the rest of the Chinese forces, who remained eager to prove themselves even as defeat loomed. Commander Zhou Zhenqiang of the Training Division's 1st Brigade suggested a counterattack and had a plan in place. His brigade would launch a frontal assault while the 3rd Brigade, stationed to his left, would execute a flanking maneuver to encircle the unsuspecting adversary. Although this strategy had potential, it was never put into action. The Nanjing garrison dismissed the proposal, citing that “too many of our troops are already worn down,” according to Tang Shengzhi's staff. They warned that if the counterattack failed, there wouldn't be enough soldiers left to defend Nanjing. Consequently, the Training Division was compelled to dig in and await the enemy's arrival. While Chinese defenders were ordered to hold their ground, the 16th Japanese Infantry Division approached Purple Mountain. The slopes of the mountain were cloaked in conifers, interspersed with dense bamboo thickets that created almost jungle-like combat conditions. As one Japanese soldier of the 20th regiment noted  “Just a few paces ahead, you couldn't see anything. Even worse, you didn't know where the enemy was. When we heard gunfire, we shot back at random. Bullets were flying everywhere.” As the Japanese soldiers ascended the slope, they were halfway to the mountain's summit when they encountered white smoke and the characteristic cracking of burning bamboo. The Chinese troops, benefiting from a favorable wind, had set fire to the bamboo. Swiftly, the Japanese soldiers drew their swords and bayonets, cutting a wide firebreak through the bamboo to halt the flames. At the forefront of Purple Mountain was a key defensive position known as Old Tiger's Cave, located just east of the mountain. As long as this location remained in Chinese control, the Japanese could not capture the mountain itself. Understanding its significance, Chinese commanders stationed a battalion of well-equipped and highly motivated soldiers from the Training Division's 5th Regiment there. Fighting erupted in the afternoon of December 8, when the Japanese commenced a fierce artillery barrage on Old Tiger's Cave, followed by an infantry assault aimed at taking the hill. Under the cold-blooded command of their leaders, the Chinese battalion employed disciplined and concentrated fire, inflicting heavy casualties on the advancing Japanese troops, who were unable to advance that day. The following morning, the Japanese intensified their assault, combining artillery fire and aerial bombardment on Old Tiger's Cave. Their infantry again attempted the treacherous climb, hoping smoke grenades would obscure the defenders' line of sight. Once more, they were thwarted, facing additional pressure as a neighboring Chinese unit launched a counterattack against the Japanese right flank. The successful defense came at a significant cost; by the afternoon, over half of the battalion defending Old Tiger's Cave had become casualties. Given the hill's exposed position and difficulties in resupply, the officers of the Training Division reluctantly decided to abandon the position. The battered battalion, now without its commander, retreated to the second-highest peak of Purple Mountain. While the loss of Old Tiger's Cave was a setback for the Training Division, it also conferred certain advantages. The Chinese soldiers withdrew to a series of prepared defensive lines through terrain they knew intimately. This stronghold centered on Xiaolingwei, a town where the Training Division had moved into new barracks over four years prior. The battalion's soldiers were familiar with every creek, hamlet, bamboo grove, and pond in the region. The Japanese faced a daunting challenge ahead. Due south of Nanjing, the 6th Japanese Division had finally caught up with the 114th Division and was deployed to its left for the final push toward Nanjing. Between the division and the city wall lay a terrain of hills and low mountains dominated by two prominent features known as General's Peak and Ox Head Peak. The task fell to the division's 13th Regiment to proceed north along the highway, while the 23rd Regiment maneuvered left around the mountains before advancing north along the Yangtze River. The division's artillery regiment, functioning at only half its typical strength due to two of its four battalions remaining in the Hangzhou Bay area, was ordered to concentrate its firepower in support of the 13th Regiment as it navigated the terrain beneath the mountain peaks. Unfortunately, the regiment's advance became mired in unexpected Chinese resistance, and with the artillery deployed too far behind to provide adequate support, divisional command decided to halt the advance until the following day, December 9. Under the cover of darkness, the artillery units were repositioned closer to the front, and the artillery commanders established their command on a hill nearby. At dawn, they began firing at the Chinese positions with much greater precision than the previous day. Meanwhile, a column of tankettes rolled down the road between General's Peak and Ox Head Peak in support of the 13th Regiment. The first tank when it came under attack from hidden mountain guns. The enemy scored several hits on the tank, forcing the driver to crawl out of the burning vehicle. The driver's pants were engulfed in flames, and as men attempted to extinguish the fire, enemy machine gun fire ripped into the driver's chest, killing him instantly. The second vehicle also came under fire from shells and burst into flames. The commander and his driver attempted to escape the turret but were trapped when another shell hit, engulfing them in flames. Unaware of the unfolding disaster, the column continued its advance, and two more tankettes were destroyed. This skirmish proved costly, resulting in the loss of four vehicles and seven men. Despite the heavy losses, the coordinated operations involving infantry, armored vehicles, and artillery gradually succeeded in dislodging the Chinese from their positions. By nightfall on December 9, the first Japanese soldiers arrived in the town of Tiexinqiao, just south of Nanjing. Meanwhile, the 23rd Regiment continued its advance north along routes west of the mountain range. This maneuver required the regiment to abandon the relatively solid road it had used thus far, opting instead for primitive trails ill-suited for wheeled transport. The major drawback of this shift was the slow transportation of artillery. The consequences became evident when one of the regiment's battalions was ordered to dislodge enemy positions on a low peak known as Hill 154, situated astride the main route of advancement. With no artillery support available, half the battalion's strength, two companies remained in the rear to safeguard the artillery pieces as they were being repositioned. The battalion ordered the remaining two infantry companies to mount an assault on Hill 154. In place of artillery, they were instructed to utilize small-caliber knee mortars. As the Japanese forces advanced towards Hill 154, the Chinese defenders opened fire with everything at their disposal, heavy and light machine guns, rifles, and mortars. The Japanese were quickly pinned down, moving slowly toward the summit under the cover of fire from the knee mortars. A breakthrough occurred when a Japanese light machine gun crew spotted a large group of Chinese soldiers repositioning on the hill. A sustained burst of fire from their weapon struck true, sending dead and wounded Chinese soldiers tumbling down the slope. Seizing the opportunity, the Japanese platoon commander sprang to his feet and charged up the hill, followed closely by the machine gunner, with the rest of the platoon trailing 10 to 20 yards behind. As they advanced, they encountered four Chinese soldiers raising their rifles to shoot. The Japanese machine gunner was quicker, firing from the hip and killing all four in an instant. The remainder of the skirmish descended into chaos. The Japanese soldiers captured the hill and took aim, firing carefully and lethally at the backs of the defeated Chinese as they fled northward. Other Japanese troops swept through the trenches with fixed bayonets, mercilessly killing all Chinese soldiers present, those who were injured, those who attempted to surrender, and even those feigning death. As Japan's 10th Army advanced on Nanjing from the south, the Shanghai Expeditionary Force was making its way in from the east. The tactical situation was fluid, fast-changing, and unpredictable, with Japanese spearheads penetrating deep into Chinese-held territory, often bypassing large enemy troop formations that would then courageously launch counterattacks from the rear. On December 8th, the 16th Division was advancing into some mountainous terrain north of Jurang where their vanguard ran into an ambush. 200 Japanese soldiers were having lunch over a 300 foot hilltop position when suddenly Captain Akao Junzo heard his comrade shout “Thousands of enemies are coming up from behind! They are heading right towards you!” Rushing outside, Akao witnessed what appeared to be a wall of Chinese soldiers marching down the valley from the rear. He dashed to the next building, bursting through the door to find his soldiers preparing lunch, he shouted at them “The enemy is here! Come with me!” The soldiers dropped their cooking utensils, grabbed their rifles, and followed Akao up the hillside behind the farm buildings. Initially, the fighting seemed evenly matched. However, the Japanese quickly brought up their two heavy machine guns, set up just 50 yards apart. Firing at a rate of 500 rounds per minute, they caught the Chinese troops in a devastating crossfire. Nine light machine guns soon joined the fray. Within moments, the cohesion of the Chinese formation collapsed, and as some soldiers broke ranks and began to retreat, Akao's men eagerly pursued them with fixed bayonets. A young, aggressive officer led the charge, wildly swinging his sword until it snapped in two. Akao watched with satisfaction. This was the kind of warfare he and his men had trained for tirelessly, month after month, and they executed their tactics with precision. However, his attention soon shifted to the hill across the valley where he had previously posted the observation squad. The entire hill was now crawling with Chinese soldiers, all firing at the peak where the small group of Japanese soldiers was entrenched in what appeared to be a desperate battle. Determined to reclaim the hill, Akao led part of his men in a charge uphill but found themselves pinned down by Chinese gunfire halfway up. A force of three squads had arrived, bringing with them what was urgently needed: knee mortars. They were accompanied by the officer with the broken sword. Akao directed the mortar fire towards the top of the hill, watching as each explosive shell detonated among the dense cluster of Chinese soldiers. Taking advantage of this momentary confusion and disarray, Akao and his men rapidly climbed the hill with swords drawn. Upon reaching the peak, they found only a few Chinese soldiers remaining. One of them pointed a handgun at the officer with the broken sword. Realizing he had no means of defending himself, the officer could only shout, “Bastard!” This unexpected outburst caused the Chinese soldier to hesitate for a brief moment before pulling the trigger. That split second marked the difference between life and death. Another Japanese officer, whose sword remained intact, lunged forward and cut down the would-be shooter. Following this, Akao and his men discovered the beleaguered Japanese squad. The soldiers' bodies had been mutilated almost beyond recognition. Some had their eyes gouged out, others had their noses or ears sliced off, and many were missing hands and feet. There were no survivors. In the early hours of December 9, just before dawn, advance units of the Japanese Army's 36th Regiment, consisting of infantry and light tanks, encountered fierce resistance from a battalion of the Chinese Training Division stationed at Hongmaoshan Hill, located southeast of the Nanjing city wall. A prolonged exchange of fire ensued, forcing the Chinese defenders to withdraw after sustaining heavy casualties. The Japanese, eager to capitalize on their advantage, followed closely. As the first light of dawn cut the horizon, they faced the imposing silhouette of the Nanjing city wall, which appeared more like a natural formation than a man-made structure. Despite their exhaustion, the soldiers erupted in victorious cries of "Banzai" and advanced energetically toward an enormous gate in the wall, this was the “Guanghua Men” or “the Gate of Enlightenment”. The Chinese defenders reigned fire, and artillery upon the Japanese columns. At that time, the gate remained shut; the moat surrounding the city was 500 feet wide and up to 15 feet deep, while the city wall towered 40 feet high. The approach to the gate was obstructed by an antitank ditch and five rows of Spanish riders, these are portable wooden frames wrapped in barbed wire. Along the road from the gate to the moat, additional rows of barbed wire further fortified the defenses. Two mountain guns, hastily transported through the rugged terrain during the 36th regiment's rapid advance to Nanjing, were positioned at the Antiaircraft Academy and commenced firing directly at the gate. While they succeeded in damaging the heavy wooden doors, it quickly became apparent that the gate had been reinforced from behind with solid beams and densely packed sandbags, so robust that, as one Japanese soldier noted, “even a row of ants wouldn't be able to make it through.” Shelling alone would not suffice to break through the defenses, prompting the call for engineers to venture into the open, exposed to enemy fire from the top of the wall, to attempt clearing the obstacles and detonating explosives at the base of the gate. While their comrades provided cover fire to keep the defenders suppressed, the engineers maneuvered past the Spanish riders to plant their explosives at the foot of the gates. An ear-splitting explosion shattered the morning air, but when the dust settled, the gate remained largely intact. To the Japanese attackers, the Chinese defenders appeared firmly entrenched; however, the reality was that they were nearing a breaking point. The artillery shelling, coupled with several Japanese air raids earlier in the day, had resulted in over 100 casualties surrounding the gate. Reinforcements were hastily summoned from nearby city sectors, including a platoon of military police cadets led by Lieutenant Xiang Hongyuan. Armed with six ZB vz 26 machine guns, the cadets commandeered a series of buses and made their way to the Gate of Enlightenment.  The hours before sunset dragged on with a tense stalemate around the Gate of Enlightenment, as neither side managed to achieve a decisive advantage. The Japanese engineers made two more perilous attempts to blow up the gate, only to find their explosives insufficient to breach the strong defenses. In a bold move, the Chinese defenders launched a risky assault outside the wall to incinerate a flour mill taller than the city wall, which, if captured, could provide the Japanese with an excellent observation point. The Chinese infantry, sprinting towards the building with jerry cans and wood, became easy targets for the Japanese fire. Despite suffering heavy losses, enough soldiers managed to reach the mill and set it ablaze. As the battle for the gate intensified on December 9, the elite 88th Division of the Chinese military became increasingly involved. The division's 262nd Brigade, comprising the 523rd and 524th Regiments, was tasked with defending the city wall between the Gate of Enlightenment and the Chinese Gate. One battalion from the 524th Regiment was dispatched to bolster the defenses at the Gate of Enlightenment. As the Japanese attacks escalated, this battalion incurred around 300 casualties. One notable instance saw 17 surviving members of a company withdraw from the battlefield, led by a platoon commander after both the company commander and his deputy had been killed. The 36th Japanese Regiment had two battalions positioned on either side of the gate, with a third held in reserve. However, that reserve battalion soon uncovered that their rear was just as perilous as the front. They were consistently attacked by Chinese stragglers from the countryside, who aimed to break through to the city gate. A Chinese unit also maintained control of a hill southwest of the Antiaircraft Academy, directing fire at Japanese soldiers within the campus. This ongoing threat from Chinese stragglers made it extremely challenging for the forward regimental positions to communicate with brigade headquarters at Qiweng Bridge farther behind. Several messengers lost their lives while trying. Ultimately, all communication shifted to wireless methods. On December 9 at noon, a solitary Japanese bomber appeared above Nanjing, but rather than its usual payload of bombs, it carried leaflets. Signed by General Matsui, the leaflets boldly declared the futility of resistance for the Chinese defenders. With Nanjing surrounded, the message conveyed that the Japanese had the power to bring the conflict directly to the Chinese. Instead, the leaflet urged surrender, stating, “The deadline for a response is tomorrow, that is the 10th”.. The Chinese were instructed to submit their response by noon to the Japanese lines near Sun Yat-sen Gate. The leaflet warned that if the Chinese did not comply, the Japanese would have no choice but to launch an assault. The tone was stern and intimidating: “The Japanese Army shall show no mercy toward those who offer resistance, treating them with extreme severity, but shall harm neither innocent civilians nor Chinese military personnel who manifest no hostility.” It emphasized the dire consequences that awaited anyone who did not lay down their arms. In response, Chinese General Tang Shengzhi reiterated his order for all troops under his command to fight to the last drop of blood. At around noon on December 10, a lone car approached Nanjing's city wall along the road from Jurong. Inside was Muto Akira, the vice chief of staff for the Central China Area Army, accompanied by another senior officer and an interpreter fluent in Chinese. Upon reaching the Japanese line near Sun Yat-sen Gate, they halted and waited. Their mission was to meet with representatives of the encircled Chinese garrison and receive their response to the previous day's request for surrender. As the minutes ticked by, there was no movement from the other side. After an hour of waiting, the three Japanese officials concluded their visit had been in vain. The vehicle turned around and retraced its path. Earlier that  morning, the Japanese had deployed a large balloon over the city wall, carrying a large white banner with a simple message in Chinese: “Give up this hopeless fight. Open the city gates and surrender!” However, this effort seemed to prove useless. As the morning progressed, Chinese shelling intensified, confirming that there was no intention among the defenders to surrender. The absence of a formal reply by the established deadline served as confirmation that the Japanese had no choice but to prepare for a massive frontal assault on the fortified city walls. Matsui wrote in his diary that day “Today at noon, we still hadn't received a reply from the Chinese to my offer of surrender. So I issued an order for the two armies to launch the attack on Nanjing beginning this afternoon. The resistance put up by the enemy is almost symbolic at this stage. It will certainly have no real effect.” The Japanese advance was set to occur along the entire front, targeting Chinese positions at Yuhuatai, the Gate of Enlightenment, Tongji Gate, and the heights of Purple Mountain. Still, one final option remained: the proposal for a three-day truce sent to both the Chinese and Japanese governments by Rabe and other foreign representatives from the day before might still be acceptable. However, this hope was dashed later that afternoon. Tang issued an order at 7:00 pm, calling for a fight to the bitter end. He warned that anyone leaving their post without permission would face severe punishment, and those failing to prevent others from withdrawing would also be penalized. Additionally, he dispatched Song Xilian and his 36th Division, his closest equivalent to a Praetorian Guard, to patrol the Yangtze docks and thwart any attempts to escape across the river. “We must defend the city with all our strength. We cannot give up an inch of our soil.” The battle for the Gate of Enlightenment remained fiercely contested. Soldiers of the 9th Japanese Infantry Division, surrounded by Chinese forces, found themselves questioning whether they were the ones laying siege or if it was the other way around. The division's 36th Regiment, entrenched directly in front of the gate, was effectively cut off from the rest of the division, lacking even a telephone line to the 18th Infantry Brigade's headquarters at Qiweng Bridge in the rear. The area was swarming with Chinese stragglers trying to return to their units. Japanese infantrymen who exposed themselves in the open risked being fired upon from all directions by unseen adversaries. Things changed at 8:00 am when the brigade's deputy commander climbed into an armored vehicle at Qiweng Bridge and led a supply column through terrain that was only partially under Japanese control. The column, carrying 500 artillery shells and machine gun ammunition, arrived without incident, replenishing the 36th Regiment, which was dangerously low on supplies. Soon after, signal troops established a telephone link to the regiment, enabling communication to flow freely. B 4:00 pm a breach had finally appeared in the outer gate. The Japanese artillery units could now see well-fortified sandbag positions inside the gate, which would also need to be destroyed, but for now, they had overcome their first obstacle. Cheers erupted among the batteries. Tang Shengzhi understood the significance of the Gate of Enlightenment in the battle for Nanjing. He had entrusted its defense to remnants of the elite German-trained 87th Infantry Division. He also deployed survivors from the 156th Division and dispatched armored cars to the section of the city wall and rolled artillery near the gate to provide close tactical support. Then suddenly cries of banzai rang out as a Rising Sun flag hoisted above the city gate. Major Ito Yoshimitsu, the commander of the 1st Battalion positioned near the Gate of Enlightenment had ordered his 1st Company to ascend the debris-laden slopes flanking the gate that had accumulated during hours of shelling. As the soldiers of the 1st Company infiltrated the gate, Ito quickly instructed the 4th Company to follow closely behind. By the time the Chinese forces recognized the critical breach in their defenses, it was too late. The two Japanese companies secured the gate and moved up to 100 yards inside the city, establishing positions in several buildings. They had created a foothold. A few miles southwest of the Gate of Enlightenment, the elite german trained 88th Chinese Infantry Division, was embroiled in fierce combat. They were defending the rugged hills in front of the Chinese Gate known as Yuhuatai, which were crucial to holding Nanjing. As General Sun Yuanliang, the division's commander, succinctly put it, “The enemy won't die by himself!” The division deployed its 527th Regiment to Yuhuatai alongside two artillery companies, while keeping the 528th Regiment in reserve. Although the 88th Division had once been part of the pre-war elite, it had suffered significant losses during months of grueling fighting, first in and around Shanghai and then during the retreat to Nanjing. The division now comprised only 6,000 to 7,000 soldiers, of which 3,000 were newcomers brought in to replenish their depleted ranks.  The division did possess one notable advantage over its opponents: the terrain. Yuhuatai was a nightmare for attackers. Military planners had long assumed invaders would assault from the south, leading to the fortification of the area. Consequently, the defenses included extensive antitank ditches, concrete-reinforced pillboxes, and rows of barbed wire, all designed to thwart an invasion. Moreover, Yuhuatai had frequently served as a training ground, allowing the 88th Division's soldiers to jump into prepared trenches during maneuvers. When the 6th Japanese Division arrived at Yuhuatai on December 10, it became immediately clear to its officers that the Chinese had transformed the area into a formidable stronghold. Strategically placed Chinese machine gun nests pinned down Japanese infantry, rendering them unable to advance or retreat. To counter this, the 6th Division set up its artillery to provide close tactical support, even at great risk. A battery commander was killed while maneuvering his guns to target a heavily fortified Chinese position. Despite the added firepower, the Japanese forces advanced slowly through the hilly landscape and sustained heavy casualties. They faced repeated obstacles from barbed wire barricades, which could only be dismantled by soldiers exposing themselves to pinpoint enemy fire. The Chinese defenders often fought to the last man; one Japanese officer noted that a pillbox had been locked from the outside, leaving the soldiers inside with no chance to escape. The experience of a company from the 6th Division's 23rd Regiment was typical. They found themselves pinned down in an antitank ditch, barely able to move. At the slightest motion, a vigilant Chinese machine gunner from a pillbox 50 yards away unleashed carefully aimed bursts of fire. Gradually, however, Japanese shelling began to weaken the Chinese positions, prompting the defenders to retreat one by one, even forcing the machine gunner to withdraw. When the Japanese troops finally emerged from cover, they spotted the fleeing gunner in the distance. Eager for revenge, they fired at him as he crossed a low ridge. He initially collapsed, only to rise again and continue fleeing. This cat-and-mouse chase occurred several times, and the Japanese soldiers couldn't tell whether they had hit him. Later that day, as they advanced further, they discovered him dead, still clutching his machine gun. The 6th Division faced the familiar issue of advancing too rapidly and bypassing Chinese units that still posed a threat. A 1,600-foot hill in the path of the 47th Regiment remained occupied by Chinese soldiers, who continued firing into the backs of the advancing Japanese troops. The Japanese forces managed to take the hill in the evening of December 10 and held it throughout the night despite repeated Chinese counterattacks. On the Chinese side, the 88th Division's 527th Regiment was engaged in particularly heavy fighting, but unlike their Japanese counterparts, they struggled with inadequate artillery support. Reluctant to risk valuable materiel, a concern that was rarely matched by a similar regard for personnel, Chinese commanders had positioned their artillery behind a low hill for protection against direct Japanese fire. However, this placement also meant they had no clear view of the enemy. Equipment lost in battle could not be replaced, but men lost were another matter. By the evening, the battle for the Gate of Enlightenment was reaching a critical point. Chinese commanders deployed every available unit to close the gap in their defenses created by the Japanese 36th Infantry Regiment, which had managed to establish a tenuous foothold near the gate. The pressure was immense, as there was no doubt that dire consequences awaited if the gate were lost. By midnight, a squad of southern Chinese soldiers from the 156th Division devised a ruthless plan to eliminate the remaining Japanese defenders, they intended to burn them out. Climbing the wall overlooking the Japanese positions with timber and cans of gasoline, they dropped burning logs onto the Japanese troops below at 1:00 am, trapping them under the heavy, flaming debris and inflicting devastating injuries. This cruel assault may have been driven by revenge, as many in the 156th Division had witnessed their comrades burned alive on the hilltop outside Nanjing just days earlier. By the morning the fight for the Gate of Enlightenment devolved into a stalemate. Nanjing was facing a siege. I would like to take this time to remind you all that this podcast is only made possible through the efforts of Kings and Generals over at Youtube. Please go subscribe to Kings and Generals over at Youtube and to continue helping us produce this content please check out www.patreon.com/kingsandgenerals. If you are still hungry after that, give my personal channel a look over at The Pacific War Channel at Youtube, it would mean a lot to me. General Tang Shengzhi led a defiant defense of Nanjing and  despite despair, civilians fortified the city, aware that its fall could shatter Chiang Kai-Shek's government. By early December, the Japanese were gradually surrounding the capital. Assaults were made against her walls and now it seemed the capital was about to face a brutal siege.

Everyone is back in the studio today, we recap our weekends, and make fun of Dave's climb up Pike's Peak.

Everyone is back in the studio today, we recap our weekends, and make fun of Dave's climb up Pike's Peak.

Send us a text"RAISE CAPITAL LIKE A LEGEND: https://offer.fundraisecapital.co/free-ebook/"Are you curious how top investors build powerful networks and close big deals? Well, listen up, because this episode goes beyond spreadsheets and cash flow and gets right to the heart of what actually works, all this and more coming right now. Subscribe on YouTube:https://www.youtube.com/channel/UCTOe79EXLDsROQ0z3YLnu1QQConnect with Ryan Miller:Linkedin: https://www.linkedin.com/in/rcmiller1/Instagram: https://www.instagram.com/makingbillionspodcast/Twitter: https://twitter.com/_MakingBillonsWebsite: https://making-billions.com/[THE GUEST]: John Azar is the founder and managing partner at Peak 15 Capital, a private equity firm specializing in equity and debt across various commercial real estate classes.[THE HOST]: Ryan Miller is an Angel investor, former VP of Finance, CFO of an insurance company, and the founder of Fund Raise Capital,  https://www.fundraisecapital.co where his strategies helped emerging fund managers and deal syndicators to report raising over $1B following his strategies.Support the showDISCLAIMER: The information in every podcast episode “episode” is provided for general informational purposes only and may not reflect the current law in your jurisdiction. By listening or viewing our episodes, you understand that no information contained in the episodes should be construed as legal or financial advice from the individual author, hosts, or guests, nor is it intended to be a substitute for legal, financial, or tax counsel on any subject matter. No listener of the episodes should act or refrain from acting on the basis of any information included in, or accessible through, the episodes without seeking the appropriate legal or other professional advice on the particular facts and circumstances at issue from a lawyer, finance, tax, or other licensed person in the recipient's state, country, or other appropriate licensing jurisdiction. No part of the show, its guests, host, content, or otherwise should be considered a solicitation for investment in any way. All views expressed in any way by guests are their own opinions and do not necessarily reflect the opinions of the show or its host(s). The host and/or its guests may own some of the assets discussed in this or other episodes, including compensation for advertisements, sponsorships, and/or endorsements. This show is for entertainment purposes only and should not be used as financial, tax, legal, or any advice whatsoever.

There's a lot of TV content out there. In fact, sometimes it feels like there's maybe too much TV to watch. However, there's a certain set of shows that it… The post e387. TV is Our Religion: The Theological Lens of Peak Television appeared first on The VoxPopcast.

In this episode of the Trust the Plan Podcast, Nick Hopwood, CFP® and Jim Pilat, CFP® of Peak Wealth shared exciting updates about their continued commitment to community impact through the Invest in Others Scholarship, now available at findingtruewealth.podbean.com YouTube: / @peakwealthmgmt Apple: rb.gy/1jqp6 (Trust the Plan Podcast) Facebook: Facebook.com/PeakWealthManagement Twitter: Twitter.com/nhopwood1 www.peakwm.com

On this episode of Pocono Mountains Magazine we're celebrating adventure, culture, and community across the Poconos! Here's what's waiting for you on this episode: Explore Big Pocono State Park with Jim Hamill — hike, zip line, and take in the fall foliage. All aboard! Ride the Stourbridge Line in Honesdale and the Lehigh Gorge Scenic Railway in Jim Thorpe with Bri & Dee. Step inside the Milford Theater revival with Deanna Fontanez — a story of creativity and vision. Discover the AgroLegacy of the Northern Poconos with a multigenerational dairy farm keeping Wayne County's heritage alive. Enjoy live music & food with sweeping views at Penn's Peak. Celebrate community heroes as Brianna Strunk highlights four inspiring nonprofits at the 22nd Annual Pocono Mountains Community Fundraiser. Catch the new Pocono Showcase featuring local talent: Little Bird and the Bad Eggs. Tune in and experience the best of the Poconos... from trails to theaters, farms to fundraisers!Stream PTN or download our app! https://poconomountains.pulse.ly/dsmd8deafj

Everyone is back in the studio today, we recap our weekends, and make fun of Dave's climb up Pike's Peak.

Dr. Pedro Barata and Dr. Rana McKay discuss the integration of innovative advances in molecular imaging and therapeutics to personalize treatment for patients with renal cell and urothelial carcinomas. TRANSCRIPT Dr. Pedro Barata: Hello, I'm Dr. Pedro Barata, your guest host of By the Book, a podcast series featuring insightful conversations between authors and editors of the ASCO Educational Book. I'm a medical oncologist at University Hospitals Seidman Cancer Center and an associate professor of medicine at Case Western Reserve University in Cleveland, Ohio. I'm also an associate editor of the ASCO Educational Book. Now, we all know the field of genitourinary cancers (GU) is evolving quite rapidly, and we have new innovations in molecular imaging as well as targeted therapeutics. Today's episode will be exploring novel approaches that are transforming the management of renal cell and urothelial carcinomas and also their potential to offer a more personalized treatment to patients. For that, joining for today's discussion is Dr. Rana McKay, a GU medical oncologist and professor at University of California San Diego. Dr. McKay will discuss her recently published article titled, “Emerging Paradigms in Genitourinary Cancers: Integrating Molecular Imaging, Hypoxia-Inducible Factor-Targeted Therapies, and Antibody-Drug Conjugates in Renal Cell and Urothelial Carcinomas.”  Our full disclosures are available in the transcript of this episode.  And with that, Rana McKay, great to have you on the podcast today. Dr. Rana McKay: Oh, thank you so much, Dr. Barata. It's really wonderful to be here with you. So, thanks for hosting. Dr. Pedro Barata: No, thanks for taking the time, and I'm looking forward to this conversation. And by the way, let me start by saying congrats on a great article in the Educational Book. Really super helpful paper. I'm recommending it to a lot of the residents and fellows at my own institution. I would like to first ask you to kind of give our listeners some context of how novel approaches in the molecular imaging as well as targeted therapeutics are actually changing the way we're managing patients with GU, but specifically with renal cell carcinoma and urothelial carcinoma. So, what are the areas you would call out as like being big areas for innovation in this context, and why are they important? Dr. Rana McKay: Very good question. And I think this is really what this article highlights. It highlights where are we going from an imaging diagnostics standpoint? Where are we going from a therapeutic standpoint? And I think if we have to step back, from the standpoint of diagnostics, we've seen PET imaging really transform diagnostics in prostate cancer with the advent of PSMA PET imaging, and now PSMA PET imaging is used as a biomarker for selection for theranostics therapy. And so, we're starting to see that enter into the RCC landscape, enter into the urothelial cancer landscape to a lesser extent. And I think it's going to potentially be transformative as these tools get more refined. I think when we think about therapeutics, what's been transformative most recently in the renal cell carcinoma landscape has been the advent of HIF2α inhibition to improve outcomes for patients. And we have seen the approval of belzutifan most recently that has reshaped the landscape. And now there's other HIF2α inhibitors that are being developed that are going to be further important as they get refined. And lastly, I think when we think about urothelial carcinoma, the greatest transformation to treatment in that context has been the displacement of cisplatin and platinum-based chemotherapy as a frontline standard with the combination of enfortumab vedotin plus pembrolizumab. And we've seen antibody-drug conjugates really reshape treatment and tremendously improve outcomes for patients. So, I think those are the three key areas of interest. Dr. Pedro Barata: So with that, let's focus first on the imaging and then we'll get to the therapeutic area. So, we know there's been a paradigm shift, really, when prostate-specific targets emerged as tracers for PET scanning. And so, we now commonly use prostate-specific membrane antigen, or PSMA-based PET scanning, and really transform how we manage prostate cancer. Now, it appears that we're kind of seeing a similar wave in renal cell carcinoma with the new radiotracer against the target carbonic anhydrase IX. What can you tell us about this? And is this going to be available to us anytime soon? And how do you think that might potentially change the way we're managing patients with RCC today? Dr. Rana McKay: First, I'll step back and say that in the context of PSMA PET imaging, we have actually been able to better understand RCC as well. So, we know that PSMA is expressed in the neovasculature of tumors, and it can actually be used to detect renal cell carcinoma tumors. It has a detection rate of about 84% when used for detection. And so, you know, I don't think it's just restricted to carbonic anhydrase IX, but we will talk about that. So, PSMA expressed in the neovasculature has a detection rate of around 84%, particularly if we're looking at clear cell RCC. CAlX is overexpressed in clear cell RCC, and it's actually used in diagnosing renal cell carcinoma when we think of CAlX IHC for diagnosing clear cell RCC. And now there are CAlX PET tracers. The first foray was with the ZIRCON study that was actually an interestingly designed study because it was designed to detect the likelihood of PET imaging to identify clear cell RCC. So, it was actually used in the early diagnostics setting when somebody presents with a renal mass to discriminate that renal mass from a clear cell versus a non-clear cell, and it was a positive study. But when I think about the potential application for these agents, you know, I think about the entire landscape of renal cell carcinoma. This is a disease that we do treat with metastasis-directed therapy. We have certainly seen patients who've undergone metastasectomy have long, durable remissions from such an approach. And I think if we can detect very early onset oligometastatic disease where a metastasis-directed therapy or SABR could be introduced - obviously tested in a trial to demonstrate its efficacy - I think it could potentially be transformative. Dr. Pedro Barata: Wonderful. It's a great summary, and I should highlight you are involved in some of those ongoing studies testing the performance of this specific PET scanning for RCC against conventional imaging, right? And to remind the listeners, thus far, for the most part, we don't really do FDG-PET for RCC. There are some specific cases we do, but in general, they're not a standard scanning. But maybe that will change in the future. Maybe RCC will have their own PSMA-PET. And to your point, there's also emerging data about the role of PSMA-PET scanning in RCC as well, as you very elegantly summarized. Wonderful. So, let me shift gears a little bit because you did, in your introduction, you did highlight a novel MOA that we have in renal cell carcinoma, approved for use, initially for VHL disease, and after that for sporadic clear cell renal cell carcinoma. We're talking about hypoxia-inducible factor 2-alpha inhibitors, or HIF2α inhibitors, such as belzutifan. But there's also others coming up. So, as a way to kind of summarize that, what can you tell us about this breakthrough in terms of therapeutic class, this MOA that got to our toolbox of options for patients with advanced RCC? Tell us a little bit what is being utilized currently in the management of advanced RCC. And where do you see the future going, as far as, is it moving early on? Is it getting monotherapy versus combinations? Maybe other therapies? What are your thoughts about that? What can you tell us about it? Dr. Rana McKay: Belzutifan is a first-in-class HIF2α inhibitor that really established clinical validation for HIF2α as a therapeutic target. When we think about the activity of this agent, the pivotal LITESPARK-005 trial really led to the approval of belzutifan in patients who were really heavily pretreated. It was patients who had received prior IO therapy, patients who had received prior VEGF-targeted therapy. And in the context of this study, we saw a median PFS of 5.6 months, and there did seem to be a tail on the curve when you looked at the 12-month PFS rate with belzutifan. It was 33.7% compared to 17.6% with everolimus. And then when we look at the response rate, it was higher with belzutifan on the order of 22-23%, and very low with everolimus, as we've previously seen. I think one of the Achilles heels of this regimen is the primary PD rate, which was 34% when used in later line. There are multiple studies that are testing belzutifan in combination across the treatment landscape. So, we have LITESPARK-011, which is looking at the combination of belzutifan plus lenvatinib in the second-line setting. We've got the MK-012 [LITESPARK-012] study, which is looking at belzutifan in various combinations in the frontline setting. So there is a combination with IO plus belzutifan. And so this is also being looked at in that context. And then we also have the LITESPARK-022 study, which is looking at pembrolizumab with belzutifan in the adjuvant setting. So there's a series of studies that will be exploring belzutifan really across the treatment landscape. Many of these studies in combination. Additionally, there are other HIF2α inhibitors that are being developed. We have casdatifan, which is another very potent HIF2α inhibitor. You know, I think pharmacologically, these are different agents. There's a different half-life, different dosing. What is going to be the recommended phase 3 dose for both agents, the EPO suppression levels, the degree of EPO suppression, and sustainability of EPO suppression is very different. So, I think we've seen data from casdatifan from the ARC-20 trial from monotherapy with a respectable response rate, over 30%, primary PD rate hovering just around 10%.  And then we've also seen data of the combination of casdatifan with cabozantinib as well that were recently presented this year. And that agent is also being tested across the spectrum of RCC. It's being looked at in combination with cabozantinib in the PEAK-1 study, and actually just at the KCRS (Kidney Cancer Research Summit), we saw the unveiling of the eVOLVE-RCC trial, which is going to be looking at a volrustomig, which is a PD-1/CTLA-4 inhibitor plus casdatifan compared to nivo-ipi in the frontline setting.  So, we're going to see some competition in this space of the HIF2α inhibitors. I think when we think of mechanism of action in that these are very potent, not a lot of off-target activity, and they target a driver mutation in the disease. And that driver mutation happens very early in the pathogenesis. These are going to be positioned much earlier in the treatment landscape. Dr. Pedro Barata: All these studies, as you're saying, look really promising. And when we talk about them, you mentioned a lot of combinations. And to me, when I think of these agents, it makes a lot of sense to combine because there's not a lot of overlapping toxicities, if you will. But perhaps for some of our listeners, who have not used HIF2α inhibitors in practice yet, and they might be thinking about that, what can you tell us about the safety profile? How do you present it to your patients, and how do you handle things like hypoxia or anemia? How do you walk through the safety profile and tolerability profile of those agents like belzutifan? Dr. Rana McKay: I think these drugs are very different than your traditional TKIs, and they don't cause the classic symptoms that are associated with traditional TKIs that many of us are very familiar with like the rash, hand-foot syndrome, hypertension, diarrhea. And honestly, these are very nuanced symptoms that patients really struggle with the chronicity of being on a chronic daily TKI. The three key side effects that I warn patients about with HIF2α inhibitors are: (1) fatigue; (2) anemia; and (3) hypoxia and dysregulation in the ability to sense oxygen levels. And so, many of these side effects - actually, all of them - are very dose-dependent. They can be very well-managed. So, we can start off with the anemia. I think it's critically important before you even start somebody on belzutifan that you are optimizing their hemoglobin and bone marrow function. Make sure they don't have an underlying iron deficiency anemia. Make sure they don't have B12 or folate deficiency. Check for these parameters. Many patients who have kidney cancer may have some hematuria, other things where there could be some low-level blood loss. So, make sure that those are resolved or you're at least addressing them and supplementing people appropriately. I monitor anemia very closely every 3 to 4 weeks, at least, when people start on these medications. And I do initiate EPO, erythropoietin, should the anemia start to worsen. And I typically use a threshold of around 10g/dL  for implementing utilization of an EPO agent, and that's been done very safely in the context of the early studies and phase 3 studies as well. Now, with regards to the hypoxia, I think it's also important to make sure that you're selecting the appropriate individual for this treatment. People who have underlying COPD, or even those individuals who have just a very high burden of disease in their lung, lymphangitic spread, pleural effusions, maybe they're already on oxygen - that's not an ideal candidate for belzutifan. Something that very easily can be done in the clinic before you think about initiating somebody on this treatment, and has certainly been integrated into some of the trials, is just a 6-minute walk test. You know, have the patient walk around the clinic with one of the MAs, one of the nurses, put the O2 sat on [measuring oxygen saturation], make sure they're doing okay. But these side effects, like I said, are very dose-dependent. Typically, if a patient requires, if the symptoms are severe, the therapy can be discontinued and dose reduced. The standing dose is 120 mg daily, and there's two dose reductions to 80 mg and 40 mg should somebody warrant that dose modification. Dr. Pedro Barata: This is relatively new, right? Like, it was not that we're used to checking oxygen levels, right? In general, we're treating these patients, so I certainly think there's a learning curve there, and some of the points that you highlight are truly critical. And I do share many of those as well in our practice. Since I have you, I want to make sure we touch base on antibody-drug conjugates as well. It's also been a hot area, a lot of developments there. When I think of urothelial carcinoma and renal cell carcinoma, I see it a little bit different. I think perhaps in urothelial carcinoma, antibody-drug conjugates, or ADCs, are somewhat established already. You already mentioned enfortumab vedotin. I might ask you to expand a little bit on that. And then in renal cell carcinoma, we have some ADCs as well that you include in your chapter, and that I would like you to tell us what's coming from that perspective. So, tell us a little bit about how do you see ADCs in general for GU tumors, particularly UC and RCC? Tell us a little bit about the complexity or perhaps the challenges you still see. At the same time, tell us about the successes. Dr. Rana McKay: Stepping back, let's just talk about like the principles and design of ADCs. So, most ADCs have three components. There's a monoclonal antibody that typically targets a cell surface antigen, which is conjugated by a linker, which is the second component, to a payload drug. And typically, that payload drug has been chemotherapy, whether it be topoisomerase or whether it be MMAE or other chemotherapeutic. We can start in the RCC space. There's been multiple antibody-drug conjugates that have been tested. There's antibody-drug conjugates to CD70, which is expressed on clear cell RCC. There's been antibody-drug conjugates to ENPP3, which is also expressed on RCC. There's antibody-drug conjugates to CDH6. And they have different payloads, like I said, whether it be topoisomerase I or other microtubule inhibitors. Now, when we think about kidney cancer, we don't treat this disease with chemotherapy. This disease is treated with immunotherapy. It is treated with treatments that target the VEGF pathway and historically has not been sensitive to chemo. So, I think even though the targets have been very exciting, we've seen very underwhelming data regarding activity, and in some context, seen increased toxicity with the ADCs. So, I think we need to tread lightly in the context of the integration and the testing of ADCs in RCC. We just came back from the KCRS meeting, and there was some very intriguing data about a c-Kit ADC that's being developed for chromophobe RCC, which is, you know, a huge unmet need, these variant tumors that really lack appropriate therapeutics. But I just caution us to tread lightly around how can we optimize the payload to make sure that the tumor that we're treating is actually sensitive to the agent that's targeting the cell kill. So, that's a little bit on the ADCs in RCC. I still think we have a long way to go and still in early testing. Now, ADCs for UC are now the standard of care. I think the prototypical agent, enfortumab vedotin, is a nectin-4-directed ADC that's conjugated to an MMAE payload and was the first ADC approved for advanced urothelial, received accelerated approval following the EV-201 trial, which was basically a multicenter, single-arm study that was investigating EV in cisplatin-ineligible patients with advanced urothelial carcinoma, and then ultimately confirmed in the EV-301 study as well. And so, that study ended up demonstrating the support superiority of EV from an overall survival standpoint, even PFS standpoint. Building on that backbone is the EV-302 study, which tested EV in combination with pembrolizumab versus platinum-based chemotherapy in the frontline setting. And that was a pivotal, landmark study that, like I said, has displaced platinum therapy as a frontline treatment for people with advanced urothelial carcinoma. And when we think about that study and the median overall survival and just how far we've come in urothelial cancer, the median OS with EV-pembro from that trial was 31 and a half months. I mean, that's just incredible. The control arm survival was 16 and a half months. The hazard ratio for OS, 0.47. I mean this is why when this data was presented, it was literally a standing ovation that lasted for several minutes because we just haven't seen data that have looked that good. And there are other antibody-drug conjugates that are being tested. We've all been involved in the saga with sacituzumab govitecan, which is a trophoblast cell surface antigen 2 (Trop-2) targeted ADC with a topoisomerase I payload. It was the second ADC to receive approval, but then that approval was subsequently withdrawn when the confirmatory phase 3 was negative, the TROPiCS-04 trial. So, approval was granted based off of the TROPHY-U-01, single-arm, phase 2 study, demonstrating a response rate of around 28% and a PFS of, you know, about 5 and a half months. But then failure to show any benefit from an OS standpoint. And I think there's a lot of controversy in the field around whether this agent still has a role in advanced urothelial carcinoma. And I think particularly for individuals who do not have molecular targets, like they're not HER2-amplified or have HER2-positivity or FGFR or other things like that. Dr. Pedro Barata: Fantastic summary, Rana. You were talking about the EV, and it came to mind that it might not be over, right, for the number of ADCs we use in clinical practice in the near future. I mean, we've seen very promising data for ADC against the HER2, right, and over-expression. It also can create some challenges, right, in the clinics because we're asking to test for HER2 expression. It's almost like, it's not exactly the same to do it in breast cancer, but it looks one more time that we're a little bit behind the breast cancer field in a lot of angles. And also has vedotin as a payload. Of course, I'm referring to disitamab vedotin, and there's very elegant data described by you in your review chapter as well. And it's going to be very interesting to see how we sequence the different ADCs, to your point as well. So, before we wrap it up, I just want to give you the opportunity to tell us if there's any area that we have not touched, any take-home points you'd like to bring up for our listeners before we call it a day. Dr. Rana McKay: Thank you so much. I have to say, you know, I was so excited at ASCO this year looking at the GU program. It was fantastic to see the progress being made, novel therapeutics that really there's a tremendous excitement about, not just in RCC and in UC, but also in prostate cancer, thinking about the integration of therapies, not just for people with refractory disease that, even though our goal is to improve survival, our likelihood of cure is low, but also thinking about how do we integrate these therapies early in the treatment landscape to enhance cure rates for patients, which is just really spectacular. We're seeing many of these agents move into the perioperative setting or in combination with radiation for localized disease. And then the special symposium on biomarkers, I mean, we've really come a long, long way. And I think that we're going to continue to evolve over the next several years. I'm super excited about where the field is going in the treatment of genitourinary malignancies. Dr. Pedro Barata: Oh, absolutely true. And I would say within the Annual Meeting, we have outstanding Educational Sessions. And just a reminder to the listeners that actually that's where the different teams or topics for the Educational Book chapters come from, from actually the educational sessions from ASCO. And your fantastic chapter is an example of that, right, focusing on advanced GU tumors. So, thank you so much, Rana, for taking the time, sharing your insights with us today on the podcast. It was a fantastic conversation as always. Dr. Rana McKay: My pleasure. Thanks so much for having me, Dr. Barata. Dr. Pedro Barata: Of course.  And thank you to our listeners for your time today. You will find the link to the article discussed today in the transcript of this episode. I also encourage you to check out the 2025 ASCO Educational Book. You'll find an incredible wealth of information there. It's free, available online, and you'll find, hopefully, super, super important information on the key science and issues that are shaping modern oncology, as we've heard from Dr. McKay and many other outstanding authors. So, thank you, everyone, and I hope to see you soon. Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. Follow today's speakers:        Dr. Pedro Barata @PBarataMD Dr. Rana McKay @DrRanaMcKay Follow ASCO on social media:        @ASCO on X (formerly Twitter)        ASCO on Bluesky       ASCO on Facebook        ASCO on LinkedIn        Disclosures:     Dr. Pedro Barata: Stock and Other Ownership Interests: Luminate Medical Honoraria: UroToday Consulting or Advisory Role: Bayer, BMS, Pfizer, EMD Serono, Eisai, Caris Life Sciences, AstraZeneca, Exelixis, AVEO, Merck, Ipson, Astellas Medivation, Novartis, Dendreon Speakers' Bureau: AstraZeneca, Merck, Caris Life Sciences, Bayer, Pfizer/Astellas Research Funding (Inst.): Exelixis, Blue Earth, AVEO, Pfizer, Merck  Dr. Rana McKay: Consulting or Advisory Role: Janssen, Novartis, Tempus, Pfizer, Astellas Medivation, Dendreon, Bayer, Sanofi, Vividion, Calithera, Caris Life Sciences, Sorrento Therapeutics, AVEO, Seattle Genetics, Telix, Eli Lilly, Blue Earth Diagnostics, Ambrx, Sumitomo Pharma Oncology, Esiai, NeoMorph, Arcus Biosciences, Daiichi Sankyo, Exelixis, Bristol Myers Squibb, Merck, Astrazeneca, Myovant Research Funding (Inst.): Bayer, Tempus, AstraZeneca, Exelixis, Bristol Myers Squibb, Oncternal Therapeutics, Artera    

In episode 270, Kelly Kennedy welcomes Laura Gabor — co-founder and COO of Ecologicca, founder of What in the Tech, angel investor, and one of The Peak's Emerging Leaders in Tech for 2024. Laura shares her journey from her immigrant roots to becoming a leader in the Canadian tech ecosystem, highlighting the pivotal experiences that shaped her as an entrepreneur and investor. From early lessons in resilience to her first angel investments, she offers a candid perspective on the challenges of building companies, raising capital, and staying true to your vision.Throughout the conversation, Laura unpacks the realities of fundraising: the misconceptions about being “too early,” the dangers of vague feedback, and the sheer persistence it takes to survive 200+ investor conversations before landing a “yes.” She also speaks openly about gender inequities in tech, the importance of inclusive leadership, and the need for stronger accountability in pay and funding. Her unfiltered insights serve as both a warning and a guide for founders — blending honesty, encouragement, and practical strategies for navigating the rollercoaster of entrepreneurship.Key Takeaways: 1. Fundraising often takes 200+ conversations before one “yes” — persistence is everything.2. Feedback like “you're too early” can kill great companies — be mindful of the weight your words carry.3. Founders must learn to filter advice; not all advice is good advice, and context matters.4. Women continue to face inequities in both pay and funding — leaders must be accountable for change.5. Angel investors need proper education too — bad investing knowledge harms founders and ecosystems.6. Building a strong support system or “village” is critical to thriving as an entrepreneur.7. Career paths don't need to follow a straight line — resilience and adaptability open new doors.8. Transparency and clarity are essential when raising capital — vagueness erodes trust.9. Founders should trust their gut as much as the data — instinct is part of good leadership.10. Legacy isn't just about business success; it's about creating impact, equity, and opportunities for others.Support Laura's work with Ecologicca & What in the Tech by engaging with the content, sharing it with your network, and amplifying the stories of women and underrepresented voices in tech. Learn more about Ecologicca: https://www.ecologicca.com/Learn more about What in the Tech?: https://www.whatinthetech.co/If you're ready to go further on your business development journey, join us inside The Catalyst Club. It's where founders, entrepreneurs, and business leaders come together to share wins, tackle challenges, and grow alongside a supportive community that understands the grind. Inside, you'll find live sessions, expert insights, and a network built to help you move the needle in your business and your life. You don't have to do this alone — your community is waiting.

Episode 190 | The Second Peak Done Right The first peak gets you to stage. The second is your chance to refine it. In this episode, John Jewett and Luke Miller cover how to improve from show to show without fading: Using timelines and worst-case planning to stay ahead Why nerves drop after the first show — and how it helps your look Data and matrix systems for food, fluids, and bodyweight Mistakes to avoid with training, travel, and PED adjustments

Hey Podtimists,Yes the rumors are true, we're back! Thanks so much for everyone being super supportive of Chase's summer paternity leave, ya'll are the best.This week we recap what games we've played over the last TWO MONTHS. Shocker, it's a lot of video games. We're so glad to be back so let's get this show on the road!---Timestamps:(0:00) - Intro(8:18) - Animation Throwdown(16:20) - The Legend of Zelda The Wind Waker(41:40) - Peak(48:29) - Dragon Quest XI: Echoes of an Elusive Age(1:06:52) - Monster Boy and the Cursed Kingdom(1:11:52) - Grimstone(1:16:28) - Octopath Traveler 1(1:25:55) - Gris(1:35:54) - Ridge Racer(1:45:17) - Clair Obscur Expedition 33(1:57:28) - Donkey Kong Bananza(2:08:43) - Outro---Games mentioned:The Legend of Zelda The Wind WakerPeakDragon Quest XI Echoes of an Elusive AgeMonster Boy and the Cursed KingdomGrimstoneOctopath Traveler 1GridRidge RacerClair Obscur Expedition 33Donkey Kong Bananza

Show Notes (contains affiliate links): Josh Got Cancelled Because of CW The radio Josh Moddified that pissed off all the hams is the Quangshen UV-K5 https://amzn.to/3JQgWsr On this week's episode of Ham Radio Crash Course, a podcast roughly based on amateur radio but mostly made up of responding to emails from listeners, hosted by Josh Nass - KI6NAZ and his reluctant wife, Leah - KN6NWZ, we talk about absolutely using 2m on CW, CW on FM and National Preparedness Month/Japanese preparedness.    Announcements: HRCC Net - https://hrcc.link.   Gigaparts Link (get 10% with code JOSH) - https://www.gigaparts.com/nsearch/?lp=JOSH   Ham Radio Minute: Absolutely 2m on CW   Ham Radio Test Study with Leah - Extra Exam HamStudy: https://hamstudy.org Support by getting something from Signal Stuff: https://signalstuff.com/?ref=622   Gordon West Ham Radio Test Prep Books with HRCC Links  -Technician: https://amzn.to/3AVHGU1 -General: https://amzn.to/4ehQ5zz -Extra: https://amzn.to/4efCqJ2   Free Fastrack to Your Ham Radio License Books on Audible (for new to Audible readers): https://www.amazon.com/hz/audible/mlp/membership/premiumplus?tag=hrccpodcast-20   Join the conversation by leaving a review on Apple Podcast for Ham Radio Crash Course podcast at https://podcasts.apple.com/us/podcast/ham-radio-crash-course/id1400794852 and/or emailing Leah@hamtactical.com. Leaving a review wherever you listen to podcasts will help Ham Radio Crash Course reach more hams and future hams and we appreciate it!   Show Topic: CW on FM   Hog Wild in the Salted Ham Cellar.    Preparedness Corner - https://www.ready.gov/september https://www.nippon.com/en/japan-data/h02513/ Email Correspondent's Tower: We answer emails with ham radio questions, comments on previous podcasts, T-shirt suggestions and everything in between.   Links mentioned in the ECT: A good summary of what DART is is available here: https://clallamdart.com/  Full Powerpoint: https://youtu.be/amyK4ZmCOSg Software-only: https://youtu.be/9X5xy-psnxw Archived HRCC Movie Club    Voted and suggested movies here - https://poll.ly/N7Jt2ACU1Epz5PSJmknw   CJ's Nifty List of HRCC Movie Club movies here - https://letterboxd.com/roguefoam/list/ham-radio-crash-course-podcast-movie-club/   The 5th Wave 10/30 War of the Worlds (2005) 10.5/30 Hitchhiker's Guide To The Galaxy 11/30 Maximum Overdrive 11/30  The Tomorrow War 11/30 On The Beach (1959) 12/30 The Postman 12/30 Soylent Green 12/30 World War Z 12/30 Waterworld 13/30 San Andreas 13/30 Airplane 14/30 The Day After (1983) 14/30 The Day After Tomorrow 14/30 Z is for Zachariah 14/30 Fall (2022) 14.5/30 Signs 15/30 Deep Impact 15/30  The Birds 15/30 Twisters (2024) 15/30  Armageddon 15.5/30 Sean of the Dead 16/30 Zombieland 16/30 The Book of Eli Ranked: 16.75/30 Love and Monsters 17/30 Frequency 17/30 2012 17/30 Greenland 17/30 12 Monkeys 17.5/30  Threads 18/30 The Survivalist 18/30 Independence Day 18.5/30 Contact (1997) 19/30 The Towering Inferno 19/30 Don't Look Up 19.5/30 Twister  19.5/30 Dante's Peak 19.5/30 Tremors 20/30 The Road 21/30 The Quiet Place 21/30 Red Dawn (1984) 22/30 Wall-E 23/30 Blast From The Past (1999) 23.5/30 28 Days Later 24.5/30 Apollo 13 24.5/30 Contagion 25/30 I Am Legend 25/30 10 Cloverfield Lane 26.5/30 The Martian 27/30   On Hiatus Indefinitely    Thank you all for listening to the podcast.  We have a lot of fun making it and the fact you listen and send us feedback means a lot to us!   Want to send us something? Josh Nass  P.O. Box 5101 Cerritos, CA 90703-5101 Support the Ham Radio Crash Course Podcast: Patreon - https://www.patreon.com/hoshnasi Shop HamTactical: http://www.hamtactical.com Shop Our Affiliates: http://hamradiocrashcourse.com/affiliates/ Shop Our Amazon Store: https://www.amazon.com/shop/hamradiocrashcourse As an Amazon Associate I earn from qualifying purchases.   Connect with Us: Website...................► http://hamradiocrashcourse.com YouTube..................► https://www.youtube.com/c/HamRadioCrashCourse Podcast...................► https://hamradiocrashcourse.podbean.com/ Discord....................► https://discord.gg/xhJMxDT Facebook................► https://goo.gl/cv5rEQ Twitter......................► https://twitter.com/Hoshnasi Instagram.................► https://instagram.com/hoshnasi (Josh) Instagram.................►https://instagram.com/hamtactical (Leah) Instagram.................►https://instagram.com/nasscorners (Leah)

This week on VG Pulse, I talk about my first week at my new job!! We start out with side notes, before diving into the regular news where we discuss the strange state of the internet right now, Nintendo continuing to be weird, and we get very confused by a new way to game with your car!! Also, y’know… something something Silksong is finally a real thing… LOL! After the news, we head on off into the discord discussions, and in a shocking turn of events, I give a review of PEAK and Millennium gives a review of Gas Station Simulator!! All this and more up next on VGP 423!! … Continue reading "VG Pulse 423: Peak Catsplosion Simulator"

With practically every “important” PlayStation 2 game being remastered, remade, and reimagined, it wasn't a surprise when Konami announced Metal Gear Solid Delta. The question wasn't “would it exist?”, but “should it exist?” This week, The Besties discuss why Metal Gear Solid 3 benefits from a high-definition, low-tweak update. And they debate just how loyal a remake should be to its source material. Get the full list of games (and other stuff) discussed at www.besties.fan. Want more episodes? Join us at patreon.com/thebesties for three bonus episodes each month!

visit: ➡️ https://raisingheights.com We're back from summer break! In this episode of Raising Heights, we catch up on all the highs, lows, peaks and pits of our summer as a family. From unforgettable Disneyland memories and the LPA convention to Jackson's brave leg surgery and Tori's return to teaching, it's been a season full of change, growth, and adventure. 00:00 - Intro & Welcome Back! 01:00 - New Podcast Setup: Cameras & Gear Talk 03:20 - Merch, Membership, and Community Shoutouts 06:45 - What is "Peak and Pit"? Family Tradition Explained 10:00 - Summer Recap: Highs & Lows Begin 12:30 - In-N-Out Opens in Washington: Local News & Fast Food Chat 16:00 - Family Road Trip to San Diego & LPA Convention 22:00 - Disneyland Adventures: Family Highlights & Parenting Wins 29:00 - Jackson's Leg Surgery: Updates & Reflections 36:00 - Tori Returns to Teaching: Life Changes & Juggling Roles 41:00 - Real Talk: Family, Vacations, and Making Choices 47:00 - Lake Days, Kayak Stories, and Kids' Milestones 52:00 - Meeting Friends & Disney Studio Tour Story 57:00 - Community Q&A, Comments, and What's Next 59:30 - Wrapping Up: Thanks, Socials, and Final Thoughts https://www.zocdoc.com/heights Don't forget to check out our merch and become a member at raisingheights.com for exclusive perks and ad-free listening! BECOME A MEMBER: visit: ➡️ https://raisingheights.com Thank you for being part of our journey. Do your best, forget the rest! Learn more about your ad choices. Visit megaphone.fm/adchoices