Podcasts about neural circuits

How do you recreate a brain circuit in a dish, and what can it unlock about our minds? Neil deGrasse Tyson, Chuck Nice, and Gary O'Reilly explore the frontier of neuroscience with Stanford neuroscientist Sergiu Pașca, to break down stem cells, how the brain forms itself, and assembloids: self-organizing brain circuits.NOTE: StarTalk+ Patrons can listen to this entire episode commercial-freehttps://startalkmedia.com/show/assembloids-recreating-the-brain-with-sergiu-pasca/Thanks to our Patrons Andy Fleishman, Khal Khumalo, Mauritz Cronje, Kyle Stone, Kathleen Fitzpatrick, Ridge Glenn, Josh Gumina, Mike Evans, Eddie Trapp, Aaron Turetsky, Kenneth TRan, Deeks, Patrick Weglinski, João Bruno Agria Russo, Lester Fernandez, Shani, Jorge Zok Yepiz, Devin Waldron, Eric D, Luke Landry, Chase Snow, Micheal Wall (Bean), Stefan, Tori Kishman, James Sellers, Alex Hayman, Kyle Gosser, Maria Balog, Vytautas Jasas, Cainã Kubiaki, Ryan Berube, James Randall, QuirkyCollisions, Bryan Staley, Jake, James Fuller, Will Behave, Gordon Pluemer, Bob Dietrich, Pizza Pockets, Nip34, Sh40l1nmunk Munken, Nick Hanna, Lyman Jordan, Robert Brashear, Lemon Life, Azeem Ahmed, John Barry, Tomas Gomez, and Joss in Cambodia for supporting us this week. Subscribe to SiriusXM Podcasts+ to listen to new episodes of StarTalk Radio ad-free and a whole week early.Start a free trial now on Apple Podcasts or by visiting siriusxm.com/podcastsplus.

Support the show to get full episodes, full archive, and join the Discord community. The Transmitter is an online publication that aims to deliver useful information, insights and tools to build bridges across neuroscience and advance research. Visit thetransmitter.org to explore the latest neuroscience news and perspectives, written by journalists and scientists. Read more about our partnership. Sign up for the “Brain Inspired” email alerts to be notified every time a new “Brain Inspired” episode is released: To explore more neuroscience news and perspectives, visit thetransmitter.org. Since the 1940s and 50s, back at the origins of what we now think of as artificial intelligence, there have been lots of ways of conceiving what it is that brains do, or what the function of the brain is. One of those conceptions, going to back to cybernetics, is that the brain is a controller that operates under the principles of feedback control. This view has been carried down in various forms to us in present day. Also since that same time period, when McCulloch and Pitts suggested that single neurons are logical devices, there have been lots of ways of conceiving what it is that single neurons do. Are they logical operators, do they each represent something special, are they trying to maximize efficiency, for example? Dmitri Chklovskii, who goes by Mitya, runs the Neural Circuits and Algorithms lab at the Flatiron Institute. Mitya believes that single neurons themselves are each individual controllers. They're smart agents, each trying to predict their inputs, like in predictive processing, but also functioning as an optimal feedback controller. We talk about historical conceptions of the function of single neurons and how this differs, we talk about how to think of single neurons versus populations of neurons, some of the neuroscience findings that seem to support Mitya's account, the control algorithm that simplifies the neuron's otherwise impossible control task, and other various topics. We also discuss Mitya's early interests, coming from a physics and engineering background, in how to wire up our brains efficiently, given the limited amount of space in our craniums. Obviously evolution produced its own solutions for this problem. This pursuit led Mitya to study the C. elegans worm, because its connectome was nearly complete- actually, Mitya and his team helped complete the connectome so he'd have the whole wiring diagram to study it. So we talk about that work, and what knowing the whole connectome of C. elegans has and has not taught us about how brains work. Chklovskii Lab. Twitter: @chklovskii. Related papers The Neuron as a Direct Data-Driven Controller. Normative and mechanistic model of an adaptive circuit for efficient encoding and feature extraction. Related episodes BI 143 Rodolphe Sepulchre: Mixed Feedback Control BI 119 Henry Yin: The Crisis in Neuroscience 0:00 - Intro 7:34 - Physicists approach for neuroscience 12:39 - What's missing in AI and neuroscience? 16:36 - Connectomes 31:51 - Understanding complex systems 33:17 - Earliest models of neurons 39:08 - Smart neurons 42:56 - Neuron theories that influenced Mitya 46:50 - Neuron as a controller 55:03 - How to test the neuron as controller hypothesis 1:00:29 - Direct data-driven control 1:11:09 - Experimental evidence 1:22:25 - Single neuron doctrine and population doctrine 1:25:30 - Neurons as agents 1:28:52 - Implications for AI 1:30:02 - Limits to control perspective

Dr. Catherine Emily Carr is a Distinguished University Professor in the Department of Biology at the University of Maryland, College Park. In the lab, Catherine is interested in understanding how animals perceive their environment. This work involves observing animal behavior in the field, as well as laboratory studies to try to understand the biology of how different fish, birds, and reptiles use their senses and their nervous systems to perceive the world around them. Much of Catherine's recent work has focused on hearing and how animals use the sounds they perceive and produce. Lately, Catherine has enjoyed spending her free time reading and doing volunteer work for the Maryland State Park system. As a volunteer she has been removing invasive species, like English Ivy and Japanese honeysuckle, from her local parks in an effort to restore the native habitats. Catherine received her undergraduate training in Zoology with first class honors at the University of Cape Town, and she completed her M.A. degree in biology at the State University New York at Buffalo. She was awarded her Ph.D. in Neuroscience at the University of California, San Diego. Afterwards, Catherine conducted postdoctoral research at CalTech, and she served briefly on the faculty at the University of Rochester before joining the faculty at the University of Maryland in 1990. She has served as a course director and co-director at the Marine Biological Laboratory at Woods Hole and has served as President, Director, and a Trustee for the Glass Foundation. Catherine has received numerous awards and honors over the years, including an Alfred P. Sloan Research Fellowship and she was awarded the Humboldt Senior Research Prize twice. She is also a fellow of the American Association for the Advancement of Science, the Hanse-Wissenschaftskolleg, and the International Society for Neuroethology. She received an honorary doctorate degree from the University of Southern Denmark, and she was named Mentor of the Year in the Neuroscience and Cognitive Science Program at the University of Maryland. In this interview, she shares more about her life and science.

Send us a Text Message.About the guest: Luis de Lecea, PhD is a neurobiologist whose lab at Stanford University studies the neural basis of sleep & wakefulness in animals.Episode summary: Nick and Dr. de Lecea discuss: the neural basis of sleep; sleep architecture & sleep phases (NREM vs. REM sleep); orexin/hypocretin neurons & the lateral hypothalamus; cortisol & stress; circadian rhythms; neuromodulators (norepinephrine, dopamine, etc); sleep across animal species; sleep drugs; ultrasound technology; and more.Related episodes:Sleep, Dreaming, Deep Neural Networks, Machine Learning & Artificial Intelligence, Overfitted Brain Hypothesis, Evolution of Fiction & Art | Erik Hoel | #43Consciousness, Anesthesia, Coma, Vegetative States, Sleep Pills (Ambien), Ketamine, AI & ChatGPT | Alex Proekt | #101*This content is never meant to serve as medical advice.Support the Show.All episodes (audio & video), show notes, transcripts, and more at the M&M Substack Try Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase.Try SiPhox Health—Affordable, at-home bloodwork w/ a comprehensive set of key health marker. Use code TRIKOMES for a 10% discount.Try the Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off.Learn all the ways you can support my efforts

In this episode of Moving Through Menopause, I am joined by Natalie McKenzie, a Cognitive Rehabilitation Therapist and Certified Brain Injury Specialist Trainer. We discuss the relationship between brain health and menopause. Did you know that hormonal fluctuations can impact the brain and cognition (thinking)? Challenges like brain fog, memory issues arise and fatigue. Natalie shares insights from her extensive experience in brain injury rehabilitation and offers tips to help women feel confident and empowered during menopause. Learn about the importance of cognitive health, some effective coping strategies, and the benefits of activities like learning new skills, journaling, and maintaining social connections. Tune in for an enlightening conversation packed with valuable advice for better cognitive well-being. 00:00 Introduction to Neural Circuits and Menopause 00:38 Welcome to the Podcast 00:47 Meet Natalie McKenzie: Cognitive Rehabilitation Expert 01:26 Understanding Cognition and Menopause 02:51 The Impact of Hormonal Changes on the Brain 05:18 Attention and Memory Issues During Menopause 11:58 Brain Injuries and Their Long-Term Effects 16:50 Cognitive Health Assessments and Online Tools 22:06 Strategies for Cognitive and Emotional Well-being 23:03 The Importance of Learning and Socialisation Natalie is available for consultations https://www.thebraininjurytherapist.co.uk/ If moving more is on your TO-DO list let Phillipa be your guide to discover her special blend of Movement Made for Women https://precizion.co.uk/onlineclasses/ Disclaimer: Please note that any information we provide in this podcast does not constitute medical guidance. You should consult your medical practitioner before making any changes that impact your health.

The National Medal of Science winner explains why she built her career around the crustacean and what it was like attending high school in a Hudson River town.

The National Medal of Science winner explains why she built her career around the crustacean and what it was like attending high school in a Hudson River town.

Biomedical researchers have long sought ways to repair spinal cord damage with the holy grail of the pursuit being the reconstitution of lost function. In the mid 1990's with the successful culture of human embryonic stem cells, and about a decade later induced pluripotent stem cells (iPSCs), the field was energized with a potential new approach to replace the lost neurons and glia cells and restoring neural connections.  In the decades since that discovery some progress has been made, however many hurdles remain, including establishing a functional synaptic connection between the transplanted and host neurons which is crucial for motor function recovery. To boost therapeutic outcomes our guests tested an ex vivo gene therapy to promote synapse formation between the donor and host neurons by expressing the synthetic excitatory synapse organizer CPTX in hiPSCs-derived neural stem and progenitor cells. Tune in to learn what they discovered. HostMartin Pera, Editor-in-Chief, Stem Cell Reports and The Jackson Laboratory@martinperaJAXGuestsHideyuki Okano, MD, PhD Keio University, Japan, Professor in the Department of Physiology and Chairman of the Graduate School of Medicine at Keio University. Professor Okano has spent decades studying neurogenesis and is currently leading a first-of-its-kind cell therapy for spinal cord injury. He has previously served as an Associate Editor for Stem Cell Reports and is a member of the Editorial Board. He is the current President of the Japanese Society of Regenerative Medicine and Vice President of the ISSCR.   Yusuke Saijo, MD. Keio University, Japan, graduated from Kyorin University School of Medicine and following a two-year initial training period, he embarked on a clinical journey, working in the field of orthopedic surgery at Keio University, specializing in the spinal cord and spinal disorders. Dr. Yusuke currently works in the research laboratory led by Professors Okano and Masaya Nakamura, where his research focuses on ex vivo cell and gene therapy for spinal cord regeneration. Supporting ContentHuman-induced pluripotent stem cell-derived neural stem/progenitor cell ex vivo gene therapy with synaptic organizer CPTX for spinal cord injury, Stem Cell ReportsAbout Stem Cell ReportsStem Cell Reports is the open access, peer-reviewed  journal of the International Society for Stem Cell Research (ISSCR) for communicating basic discoveries in stem cell research, in addition to translational and clinical studies. Stem Cell Reports focuses on original research with conceptual or practical advances that are of broad interest to stem cell biologists and clinicians.Twitter: @StemCellReportsAbout ISSCRWith nearly 5,000 members from 75+ countries, the International Society for Stem Cell Research (@ISSCR) is the preeminent global, cross-disciplinary, science-based organization dedicated to stem cell research and its translation to the clinic. The ISSCR mission is to promote excellence in stem cell science and applications to human health.ISSCR StaffKeith Alm, Chief Executive OfficerYvonne Fisher, Managing Editor, Stem Cell ReportsKym Kilbourne, Director of Media and Strategic CommunicationsJack Mosher, Scientific AdvisorVoice WorkBen Snitkoff

Arkarup Banerjee | School of Biological Science / Cold Spring Harbor Laboratory, NY "Neural Circuits for Vocal Communication: Insights from the Singing Mice." My long-standing interest is to understand how circuits of interacting neurons give rise to natural, adaptive behaviors. Using vocal communication behavior across rodent species, my lab at CSHL pursues two complementary questions. How does the auditory system interact with the motor system to generate the fast sensorimotor loop required for vocal communication? What are the neural circuit modifications that allow behavioral novelty to emerge during evolution? In this talk, I will introduce you to the rich vocal life of the Costa-Rican singing mice. Next, I will describe a series of experiments that were performed to demonstrate the role of the motor cortex in controlling vocal flexibility in this species. In closing, I will discuss our ongoing efforts to identify neural circuit differences between singing mice and lab mice using high-throughput connectomics. Together, by combining neural circuit analysis of a natural behavior with comparative evolutionary analyses across species, we stand to gain insight into the function and evolution of neural circuits for social behaviors.

Guests: Vijay Balasubramanian, External Professor at the Santa Fe Institute, Cathy and Marc Lasry Professor of Physics at the University of PennsylvaniaGeoffrey West, Shannan Distinguished Professor and Past President, Santa Fe InstituteHosts: Abha Eli Phoboo & Chris KempesProducer: Katherine MoncurePodcast theme music: Mitch MignanoOther Music: Blue Dot Sessions, Pink House Music, Eardeer, and Craig Smith.Follow us on: Twitter • YouTube • Facebook • Instagram • LinkedIn  • BlueskySFI programs: Complexity Global School Complexity Explorer: Fractals & ScalingEducationBooks & Stories: Tell Me Why by Arkady LeokumScale by Geoffrey West“Funes, the Memorious” by Jorge Luis BorgesTalks: How the Brain Makes You: Collective Intelligence and Computation by Neural Circuits by Vijay BalasubramanianThe Future of the Planet: Life, Growth and Death in Organisms, Cities and Companies by Geoffrey WestEnergy, Scaling & The Future of Life on Earth by Geoffrey WestComplex Time Working Group: “What is Sleep?” with Geoffrey West, Van Savage, Alex HermanPapers: “Brain Power” in PNAS (August 2, 2021) doi.org/10.1073/pnas.210702211“The Physical Effects of Learning” preprint published in biorxiv“Unraveling why we sleep: Quantitative analysis reveals abrupt transition from neural reorganization to repair in early development” in Science Advances (September 18, 2020) DOI: 10.1126/sciadv.aba0398“The Scales That Limit: The Physical Boundaries of Evolution” in Frontiers in Ecology and Evolution (August 7, 2019) doi.org/10.3389/fevo.2019.00242

In this episode, I share why I believe these 3 nerves are so powerful to target for manual therapy, nerve glides, or movement drills. The 3 nerves are the trigeminal nerve, the accessory nerve, and the obturator nerve. I break down the connections to the fascial containers of our axial skeleton and the role they play in viscera and neural influences on the body, why they are easy to target, and why spinal articulation can also be a powerful tool to combine with these nerve glides and targeted treatment. During this episode, I also share about recently learning that the pelvic splanchnic nerves, which have been classified as parasympathetic for decades, in fact, are not! So what does this mean for us and our understanding of the ANS? Listen to hear my thoughts on it.Resources mentioned in the podcast:The Barral Institute- if you sign up for a course be sure to let the know Anna Hartman referred you! The Power of the Trigeminal Nerve episode 28 Cervical fascia containers (CRAZY Link Between Neck Pain & Reflux | Neck Pain Home Treatments)SCIENCE article- Sacral Autonomic Outflow is Sympathetic SCIENCE article- Neural Circuits get Rewired Trigeminal Nerve GlideErb's Point Accessory Nerve Glide Obturator Nerve Glide Spinal Roll DownConsidering the viscera as a source of musculoskeletal pain and dysfunction is a great way to ensure a more true whole body approach to care, however it can be a bit overwhelming on where to start, which is exactly why I created the Visceral Referral Cheat Sheet. This FREE download will help you to learn the most common visceral referral patterns affecting the musculoskeletal system. Download it at www.unrealresultspod.com=================================================Watch the podcast on YouTube and subscribe!Join the MovementREV email list to stay up to date on the Unreal Results Podcast and MovementREV education. Be social and follow me:Instagram | Facebook | Twitter | YouTube

Neil P. Jones Ph.D. is an expert on the spectrum of Depressions, including their diverse manifestations and impact on cognitive-behavioral processes, for example accompanying rumination, stress-related anxiety, and anhedonia. This podcast focuses on subtypes of depression relating to brain pathways.

D'Angelo, Egidio, und Stefano Casali. „Seeking a Unified Framework for Cerebellar Function and Dysfunction: From Circuit Operations to Cognition“. Frontiers in Neural Circuits 6 (2013). https://doi.org/10.3389/fncir.2012.00116.

What if you could have a map of the different states of your nervous system to help you understand where you're at and how to get to where you want to be?     The autonomic nervous system is made up of 3 distinct neural circuits. How you feel, think, and act can vary greatly depending on the neural circuit in which you're operating.   Growing in awareness of the state of your nervous system helps you better understand your reactions, deepen your somatic awareness, and heal, regulate & grow.   In today's episode, I'll help you map out each of the 3 nervous system states – how they impact your emotions, responses, and physical well-being, and then I'll give you practical strategies to regulate so you can feel more at ease and empowered.      ASK MICHELLE A QUESTION!     REGULATION RESOURCES      TAKE THE PERSONALITY PATTERN QUIZ! BOOK A FREE 30-MINUTE CALL WITH MICHELLE     FB COMMUNITY: The Calm Mom Collective JOIN ME ON INSTAGRAM: @michellegrosser.coach “I love The Calm Mom Podcast!” ← if that sounds like you, please consider rating and reviewing our show!  This helps us support more women, just like you, on their motherhood journey.  Click here, scroll to the bottom, tap to rate with five stars, and select “Write a Review.”  Then be sure to let me know what you loved most about the episode!  

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.01.547328v1?rss=1 Authors: Wietek, J., Nozownik, A., Pulin, M., Saraf-Sinik, I., Matosevich, N., Malan, D., Brown, B. J., Dine, J., Levy, R., Litvin, A., Regev, N., Subramaniam, S., Bitton, E., Benjamin, A., Copits, B. A., Sasse, P., Rost, B. R., Schmitz, D., Soba, P., Nir, Y., Wiegert, J. S., Yizhar, O. Abstract: Information is transmitted between brain regions through the release of neurotransmitters from long-range projecting axons. Understanding how the activity of such long-range connections contributes to behavior requires efficient methods for reversibly manipulating their function. Chemogenetic and optogenetic tools, acting through endogenous G-protein coupled receptor (GPCRs) pathways, can be used to modulate synaptic transmission, but existing tools are limited in sensitivity, spatiotemporal precision, or spectral multiplexing capabilities. Here we systematically evaluated multiple bistable opsins for optogenetic applications and found that the Platynereis dumerilii ciliary opsin (PdCO) is an efficient, versatile, light-activated bistable GPCR that can suppress synaptic transmission in mammalian neurons with high temporal precision in-vivo. PdCO has superior biophysical properties that enable spectral multiplexing with other optogenetic actuators and reporters. We demonstrate that PdCO can be used to conduct reversible loss-of-function experiments in long-range projections of behaving animals, thereby enabling detailed synapse-specific functional circuit mapping. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.06.21.545947v1?rss=1 Authors: Zavatone-Veth, J. A., Masset, P., Tong, W. L., Zak, J. D., Murthy, V. N., Pehlevan, C. Abstract: Within a single sniff, the mammalian olfactory system can decode the identity and concentration of odorants wafted on turbulent plumes of air. Yet, it must do so given access only to the noisy, dimensionally-reduced representation of the odor world provided by olfactory receptor neurons. As a result, the olfactory system must solve a compressed sensing problem, relying on the fact that only a handful of the millions of possible odorants are present in a given scene. Inspired by this principle, past works have proposed normative compressed sensing models for olfactory decoding. However, these models have not captured the unique anatomy and physiology of the olfactory bulb, nor have they shown that sensing can be achieved within the 100-millisecond timescale of a single sniff. Here, we propose a rate-based Poisson compressed sensing circuit model for the olfactory bulb. This model maps onto the neuron classes of the olfactory bulb, and recapitulates salient features of their connectivity and physiology. For circuit sizes comparable to the human olfactory bulb, we show that this model can accurately detect tens of odors within the timescale of a single sniff. We also show that this model can perform Bayesian posterior sampling for accurate uncertainty estimation. Fast inference is possible only if the geometry of the neural code is chosen to match receptor properties, yielding a distributed neural code that is not axis-aligned to individual odor identities. Our results illustrate how normative modeling can help us map function onto specific neural circuits to generate new hypotheses. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Anthropogeny, has provided many new discoveries over the past decade, ranging from new fossil finds to ancient DNA data, including from extinct hominins. This CARTA symposium highlights where the future efforts should be focused and what type of novel collaborations are most promising for improving our understanding of the human phenomenon. Terry Sejnowski discusses how large-scale neural network models have inspired major advances in artificial intelligence. Sarah Tishkoff talks on how Africa is thought to be the ancestral homeland of all modern human populations. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Education] [Show ID: 38631]

Anthropogeny, has provided many new discoveries over the past decade, ranging from new fossil finds to ancient DNA data, including from extinct hominins. This CARTA symposium highlights where the future efforts should be focused and what type of novel collaborations are most promising for improving our understanding of the human phenomenon. Terry Sejnowski discusses how large-scale neural network models have inspired major advances in artificial intelligence. Sarah Tishkoff talks on how Africa is thought to be the ancestral homeland of all modern human populations. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Education] [Show ID: 38631]

Anthropogeny, has provided many new discoveries over the past decade, ranging from new fossil finds to ancient DNA data, including from extinct hominins. This CARTA symposium highlights where the future efforts should be focused and what type of novel collaborations are most promising for improving our understanding of the human phenomenon. Terry Sejnowski discusses how large-scale neural network models have inspired major advances in artificial intelligence. Sarah Tishkoff talks on how Africa is thought to be the ancestral homeland of all modern human populations. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Education] [Show ID: 38631]

Anthropogeny, has provided many new discoveries over the past decade, ranging from new fossil finds to ancient DNA data, including from extinct hominins. This CARTA symposium highlights where the future efforts should be focused and what type of novel collaborations are most promising for improving our understanding of the human phenomenon. Terry Sejnowski discusses how large-scale neural network models have inspired major advances in artificial intelligence. Sarah Tishkoff talks on how Africa is thought to be the ancestral homeland of all modern human populations. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Education] [Show ID: 38631]

Anthropogeny, has provided many new discoveries over the past decade, ranging from new fossil finds to ancient DNA data, including from extinct hominins. This CARTA symposium highlights where the future efforts should be focused and what type of novel collaborations are most promising for improving our understanding of the human phenomenon. Terry Sejnowski discusses how large-scale neural network models have inspired major advances in artificial intelligence. Sarah Tishkoff talks on how Africa is thought to be the ancestral homeland of all modern human populations. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Education] [Show ID: 38631]

Anthropogeny, has provided many new discoveries over the past decade, ranging from new fossil finds to ancient DNA data, including from extinct hominins. This CARTA symposium highlights where the future efforts should be focused and what type of novel collaborations are most promising for improving our understanding of the human phenomenon. Terry Sejnowski discusses how large-scale neural network models have inspired major advances in artificial intelligence. Sarah Tishkoff talks on how Africa is thought to be the ancestral homeland of all modern human populations. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Education] [Show ID: 38631]

Anthropogeny, has provided many new discoveries over the past decade, ranging from new fossil finds to ancient DNA data, including from extinct hominins. This CARTA symposium highlights where the future efforts should be focused and what type of novel collaborations are most promising for improving our understanding of the human phenomenon. Terry Sejnowski discusses how large-scale neural network models have inspired major advances in artificial intelligence. Sarah Tishkoff talks on how Africa is thought to be the ancestral homeland of all modern human populations. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Education] [Show ID: 38631]

Anthropogeny, has provided many new discoveries over the past decade, ranging from new fossil finds to ancient DNA data, including from extinct hominins. This CARTA symposium highlights where the future efforts should be focused and what type of novel collaborations are most promising for improving our understanding of the human phenomenon. Terry Sejnowski discusses how large-scale neural network models have inspired major advances in artificial intelligence. Sarah Tishkoff talks on how Africa is thought to be the ancestral homeland of all modern human populations. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Education] [Show ID: 38631]

Anthropogeny, has provided many new discoveries over the past decade, ranging from new fossil finds to ancient DNA data, including from extinct hominins. This CARTA symposium highlights where the future efforts should be focused and what type of novel collaborations are most promising for improving our understanding of the human phenomenon. Terry Sejnowski discusses how large-scale neural network models have inspired major advances in artificial intelligence. Sarah Tishkoff talks on how Africa is thought to be the ancestral homeland of all modern human populations. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Education] [Show ID: 38631]

Anthropogeny, has provided many new discoveries over the past decade, ranging from new fossil finds to ancient DNA data, including from extinct hominins. This CARTA symposium highlights where the future efforts should be focused and what type of novel collaborations are most promising for improving our understanding of the human phenomenon. Terry Sejnowski discusses how large-scale neural network models have inspired major advances in artificial intelligence. Sarah Tishkoff talks on how Africa is thought to be the ancestral homeland of all modern human populations. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Education] [Show ID: 38631]

27 January 2023 - “I really think our special feature (as humans) is communication and shared knowledge,” neuroscientist Cori Bargmann told the EMBO podcast. Bargmann is the Torsten N. Wiesel Professor and Head of the Laboratory of Neural Circuits and Behavior at The Rockefeller University in New York, where her group studies neurobiology using C. elegans as their main model. Cori Bargmann has been an Associate EMBO Member since 2011. On this episode of the EMBO podcast we discussed the evolution of behavior, open science, a worm's sense of smell, the Human Brain Initiative, mentorship, and much more.

------------------Support the channel------------ Patreon: https://www.patreon.com/thedissenter PayPal: paypal.me/thedissenter PayPal Subscription 1 Dollar: https://tinyurl.com/yb3acuuy PayPal Subscription 3 Dollars: https://tinyurl.com/ybn6bg9l PayPal Subscription 5 Dollars: https://tinyurl.com/ycmr9gpz PayPal Subscription 10 Dollars: https://tinyurl.com/y9r3fc9m PayPal Subscription 20 Dollars: https://tinyurl.com/y95uvkao ------------------Follow me on--------------------- Facebook: https://www.facebook.com/thedissenteryt/ Twitter: https://twitter.com/TheDissenterYT This show is sponsored by Enlites, Learning & Development done differently. Check the website here: http://enlites.com/ Dr. Lucia Melloni is a Research Leader of the Neural Circuits, Consciousness and Cognition Group at the Max Planck Institute for Empirical Aesthetics. Her research areas include domain-general cortical computations, neural mechanisms by which the brain predictively controls sensory processing and perception, brain mechanism subserving language comprehension, and possibilities and limits of brain plasticity to restore cognitive functions. In this episode, we talk about consciousness, language, and neuroplasticity. We start with consciousness, how it is studied in neuroscience, the neural correlates of consciousness, the hard problem of consciousness, and its causal power over behavior. We discuss conscious perception, and how language connects to consciousness. Finally, we talk about the limits of neuroplasticity. -- A HUGE THANK YOU TO MY PATRONS/SUPPORTERS: KARIN LIETZCKE, ANN BLANCHETTE, PER HELGE LARSEN, LAU GUERREIRO, JERRY MULLER, HANS FREDRIK SUNDE, BERNARDO SEIXAS, HERBERT GINTIS, RUTGER VOS, RICARDO VLADIMIRO, CRAIG HEALY, OLAF ALEX, PHILIP KURIAN, JONATHAN VISSER, JAKOB KLINKBY, ADAM KESSEL, MATTHEW WHITINGBIRD, ARNAUD WOLFF, TIM HOLLOSY, HENRIK AHLENIUS, JOHN CONNORS, PAULINA BARREN, FILIP FORS CONNOLLY, DAN DEMETRIOU, ROBERT WINDHAGER, RUI INACIO, ARTHUR KOH, ZOOP, MARCO NEVES, COLIN HOLBROOK, SUSAN PINKER, PABLO SANTURBANO, SIMON COLUMBUS, PHIL KAVANAGH, JORGE ESPINHA, CORY CLARK, MARK BLYTH, ROBERTO INGUANZO, MIKKEL STORMYR, ERIC NEURMANN, SAMUEL ANDREEFF, FRANCIS FORDE, TIAGO NUNES, BERNARD HUGUENEY, ALEXANDER DANNBAUER, FERGAL CUSSEN, YEVHEN BODRENKO, HAL HERZOG, NUNO MACHADO, DON ROSS, JONATHAN LEIBRANT, JOÃO LINHARES, OZLEM BULUT, NATHAN NGUYEN, STANTON T, SAMUEL CORREA, ERIK HAINES, MARK SMITH, J.W., JOÃO EIRA, TOM HUMMEL, SARDUS FRANCE, DAVID SLOAN WILSON, YACILA DEZA-ARAUJO, IDAN SOLON, ROMAIN ROCH, DMITRY GRIGORYEV, TOM ROTH, DIEGO LONDOÑO CORREA, YANICK PUNTER, ADANER USMANI, CHARLOTTE BLEASE, NICOLE BARBARO, ADAM HUNT, PAWEL OSTASZEWSKI, AL ORTIZ, NELLEKE BAK, KATHRINE AND PATRICK TOBIN, GUY MADISON, GARY G HELLMANN, SAIMA AFZAL, ADRIAN JAEGGI, NICK GOLDEN, PAULO TOLENTINO, JOÃO BARBOSA, JULIAN PRICE, EDWARD HALL, HEDIN BRØNNER, DOUGLAS P. FRY, FRANCA BORTOLOTTI, GABRIEL PONS CORTÈS, URSULA LITZCKE, DENISE COOK, SCOTT, ZACHARY FISH, TIM DUFFY, TRADERINNYC, SUNNY SMITH, JON WISMAN, MORTEN EIKELAND, AND DR BYRD! A SPECIAL THANKS TO MY PRODUCERS, YZAR WEHBE, JIM FRANK, ŁUKASZ STAFINIAK, IAN GILLIGAN, LUIS CAYETANO, TOM VANEGDOM, CURTIS DIXON, BENEDIKT MUELLER, VEGA GIDEY, THOMAS TRUMBLE, AND NUNO ELDER! AND TO MY EXECUTIVE PRODUCERS, MICHAL RUSIECKI, JAMES PRATT, MATTHEW LAVENDER, SERGIU CODREANU, AND BOGDAN KANIVETS!

Huberman Lab Podcast Notes Key Takeaways Creativity stems from neural structures in the brain that can be accessed in a certain sequence to spark creativity in different domains of lifeTruly creative acts are novel combinations of some things that reveal a fundamental feature about how our brain or the real world workCreativity captivates us because it's useful in some way – just coming up with a novel combination of things (like wings on a fish tank) is not inherently creativeIf you want to be creative, you need to seek out and forage for information about existing rules – you can't break rules unless you know themKey elements of creativity: (1) divergent thinking – brainstorming, exploring ideas – taking one stimulus and radiating out thoughts, events, and concepts from that thing; (2) convergent thinking – taking loose ideas and synthesizing them into a specific framework or coherent idea(s) To enhance divergent thinking try 5 minutes of open monitoring meditation: sit with eyes closed and just let thoughts flow in and outTo enhance convergent thinking try 5 minutes of focused attention monitoring: sit with eyes closed or open and focus on a specific object, sound, pointSkip the caffeine to enhance divergent thinking, consume caffeine to enhance convergent thinkingRead the full notes @ podcastnotes.orgIn this episode, I explain how the brain engages in creative thinking and, based on that mechanistic understanding, the tools to improve one's ability to think creatively and innovate in any area. I discuss how convergent and divergent thinking are essential for generating creative ideas and provide three types of meditation tools (open monitoring meditation, focused attention meditation & non-sleep deep rest; NSDR), which improve our ability to engage in these creative thinking patterns in specific and powerful ways. I also discuss how dopamine and mood contribute to the creative process and describe behavioral, nutritional and supplementation-based approaches for increasing dopamine to engage in creative thought and implementation. I explain how movement and storytelling (narrative) approaches can generate novel creative ideas and how substances like alcohol, cannabis, and psilocybin impact our creative ability. Excitingly, creativity is a skill that can be cultivated and enhanced; this episode outlines many tools to help anyone access creativity and apply creative patterns of thought to different domains of life. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman ROKA: https://www.roka.com/huberman Thesis: https://takethesis.com/huberman LMNT: https://drinklmnt.com/huberman InsideTracker: https://www.insidetracker.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman For the full show notes, visit hubermanlab.com Timestamps (00:00:00) Creativity (00:04:30) ROKA, Thesis, LMNT, Momentous (00:08:51) What is Creativity? (00:11:16) Creativity in Visual Arts, Escher & Banksy (00:23:37) Neural Circuits of Creativity (00:31:58) AG1 (Athletic Greens) (00:33:13) Creative Ideas & Divergent Thinking (00:42:09) Testing Creative Ideas & Convergent Thinking (00:46:41) Dopamine, Convergent & Divergent Thinking Pathways (00:57:02) InsideTracker (00:58:06) Tool: Open Monitoring Meditation & Divergent Thinking (01:07:38) Tool: Focused Attention Meditation & Convergent Thinking (01:11:06) Mood, Creativity & Dopamine (01:16:00) Tool: Mood Calibrating, Caffeine & Dopamine (01:23:41) Dopamine Supplementation; L-Tyrosine, Caffeine (01:30:15) Tool: Non-Sleep Deep Rest, Mesocortical Dopamine & Divergent Thinking (01:43:130 Serotonin, Psylocibin & Creative Thinking (01:49:13) Alcohol & Autobiographical Scripting; Cannabis (01:52:04) Attention Deficit Hyperactivity Disorder (ADHD) & Creativity (01:54:45) Tool: Movement & Divergent Thinking (02:01:02) Tool: Narratives & Storytelling for Creativity (02:14:47) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Neural Network Newsletter, Social Media Disclaimer Title Card Photo Credit: Mike Blabac

Huberman Lab: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- In this episode, I explain how the brain engages in creative thinking and, based on that mechanistic understanding, the tools to improve one's ability to think creatively and innovate in any area. I discuss how convergent and divergent thinking are essential for generating creative ideas and provide three types of meditation tools (open monitoring meditation, focused attention meditation & non-sleep deep rest; NSDR), which improve our ability to engage in these creative thinking patterns in specific and powerful ways. I also discuss how dopamine and mood contribute to the creative process and describe behavioral, nutritional and supplementation-based approaches for increasing dopamine to engage in creative thought and implementation. I explain how movement and storytelling (narrative) approaches can generate novel creative ideas and how substances like alcohol, cannabis, and psilocybin impact our creative ability. Excitingly, creativity is a skill that can be cultivated and enhanced; this episode outlines many tools to help anyone access creativity and apply creative patterns of thought to different domains of life. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman ROKA: https://www.roka.com/huberman Thesis: https://takethesis.com/huberman LMNT: https://drinklmnt.com/huberman InsideTracker: https://www.insidetracker.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman For the full show notes, visit hubermanlab.com Timestamps (00:00:00) Creativity (00:04:30) ROKA, Thesis, LMNT, Momentous (00:08:51) What is Creativity? (00:11:16) Creativity in Visual Arts, Escher & Banksy (00:23:37) Neural Circuits of Creativity (00:31:58) AG1 (Athletic Greens) (00:33:13) Creative Ideas & Divergent Thinking (00:42:09) Testing Creative Ideas & Convergent Thinking (00:46:41) Dopamine, Convergent & Divergent Thinking Pathways (00:57:02) InsideTracker (00:58:06) Tool: Open Monitoring Meditation & Divergent Thinking (01:07:38) Tool: Focused Attention Meditation & Convergent Thinking (01:11:06) Mood, Creativity & Dopamine (01:16:00) Tool: Mood Calibrating, Caffeine & Dopamine (01:23:41) Dopamine Supplementation; L-Tyrosine, Caffeine (01:30:15) Tool: Non-Sleep Deep Rest, Mesocortical Dopamine & Divergent Thinking (01:43:130 Serotonin, Psylocibin & Creative Thinking (01:49:13) Alcohol & Autobiographical Scripting; Cannabis (01:52:04) Attention Deficit Hyperactivity Disorder (ADHD) & Creativity (01:54:45) Tool: Movement & Divergent Thinking (02:01:02) Tool: Narratives & Storytelling for Creativity (02:14:47) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Neural Network Newsletter, Social Media Disclaimer Title Card Photo Credit: Mike Blabac

In this episode, I explain how the brain engages in creative thinking and, based on that mechanistic understanding, the tools to improve one's ability to think creatively and innovate in any area. I discuss how convergent and divergent thinking are essential for generating creative ideas and provide three types of meditation tools (open monitoring meditation, focused attention meditation & non-sleep deep rest; NSDR), which improve our ability to engage in these creative thinking patterns in specific and powerful ways. I also discuss how dopamine and mood contribute to the creative process and describe behavioral, nutritional and supplementation-based approaches for increasing dopamine to engage in creative thought and implementation. I explain how movement and storytelling (narrative) approaches can generate novel creative ideas and how substances like alcohol, cannabis, and psilocybin impact our creative ability. Excitingly, creativity is a skill that can be cultivated and enhanced; this episode outlines many tools to help anyone access creativity and apply creative patterns of thought to different domains of life. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman ROKA: https://www.roka.com/huberman Thesis: https://takethesis.com/huberman LMNT: https://drinklmnt.com/huberman InsideTracker: https://www.insidetracker.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman For the full show notes, visit hubermanlab.com Timestamps (00:00:00) Creativity (00:04:30) ROKA, Thesis, LMNT, Momentous (00:08:51) What is Creativity? (00:11:16) Creativity in Visual Arts, Escher & Banksy (00:23:37) Neural Circuits of Creativity (00:31:58) AG1 (Athletic Greens) (00:33:13) Creative Ideas & Divergent Thinking (00:42:09) Testing Creative Ideas & Convergent Thinking (00:46:41) Dopamine, Convergent & Divergent Thinking Pathways (00:57:02) InsideTracker (00:58:06) Tool: Open Monitoring Meditation & Divergent Thinking (01:07:38) Tool: Focused Attention Meditation & Convergent Thinking (01:11:06) Mood, Creativity & Dopamine (01:16:00) Tool: Mood Calibrating, Caffeine & Dopamine (01:23:41) Dopamine Supplementation; L-Tyrosine, Caffeine (01:30:15) Tool: Non-Sleep Deep Rest, Mesocortical Dopamine & Divergent Thinking (01:43:130 Serotonin, Psylocibin & Creative Thinking (01:49:13) Alcohol & Autobiographical Scripting; Cannabis (01:52:04) Attention Deficit Hyperactivity Disorder (ADHD) & Creativity (01:54:45) Tool: Movement & Divergent Thinking (02:01:02) Tool: Narratives & Storytelling for Creativity (02:14:47) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Neural Network Newsletter, Social Media Disclaimer Title Card Photo Credit: Mike Blabac

Neuroscience has made great strides in the last decade following the Brain Research Through Advancing Innovative Neurotechnologies (BRAIN) Initiative, a science and engineering grand challenge that has greatly accelerated research on large-scale recordings from neurons and reconstructions of neural circuits. Large-scale neural network models have in turn inspired major advances in artificial intelligence. These network models have been trained on large-scale data sets to recognize objects in images, caption photographs, and translate text between languages. The most recent advance has been the emergence of pre-trained foundational language models that are self-supervised and can be adapted with fine tuning to a wide range of natural language tasks, each of which previously would have required a separate network model. This is one step closer to the extraordinary versatility of human language. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Education] [Show ID: 38302]

Neuroscience has made great strides in the last decade following the Brain Research Through Advancing Innovative Neurotechnologies (BRAIN) Initiative, a science and engineering grand challenge that has greatly accelerated research on large-scale recordings from neurons and reconstructions of neural circuits. Large-scale neural network models have in turn inspired major advances in artificial intelligence. These network models have been trained on large-scale data sets to recognize objects in images, caption photographs, and translate text between languages. The most recent advance has been the emergence of pre-trained foundational language models that are self-supervised and can be adapted with fine tuning to a wide range of natural language tasks, each of which previously would have required a separate network model. This is one step closer to the extraordinary versatility of human language. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Education] [Show ID: 38302]

Neuroscience has made great strides in the last decade following the Brain Research Through Advancing Innovative Neurotechnologies (BRAIN) Initiative, a science and engineering grand challenge that has greatly accelerated research on large-scale recordings from neurons and reconstructions of neural circuits. Large-scale neural network models have in turn inspired major advances in artificial intelligence. These network models have been trained on large-scale data sets to recognize objects in images, caption photographs, and translate text between languages. The most recent advance has been the emergence of pre-trained foundational language models that are self-supervised and can be adapted with fine tuning to a wide range of natural language tasks, each of which previously would have required a separate network model. This is one step closer to the extraordinary versatility of human language. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Education] [Show ID: 38302]

Neuroscience has made great strides in the last decade following the Brain Research Through Advancing Innovative Neurotechnologies (BRAIN) Initiative, a science and engineering grand challenge that has greatly accelerated research on large-scale recordings from neurons and reconstructions of neural circuits. Large-scale neural network models have in turn inspired major advances in artificial intelligence. These network models have been trained on large-scale data sets to recognize objects in images, caption photographs, and translate text between languages. The most recent advance has been the emergence of pre-trained foundational language models that are self-supervised and can be adapted with fine tuning to a wide range of natural language tasks, each of which previously would have required a separate network model. This is one step closer to the extraordinary versatility of human language. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Education] [Show ID: 38302]

Neuroscience has made great strides in the last decade following the Brain Research Through Advancing Innovative Neurotechnologies (BRAIN) Initiative, a science and engineering grand challenge that has greatly accelerated research on large-scale recordings from neurons and reconstructions of neural circuits. Large-scale neural network models have in turn inspired major advances in artificial intelligence. These network models have been trained on large-scale data sets to recognize objects in images, caption photographs, and translate text between languages. The most recent advance has been the emergence of pre-trained foundational language models that are self-supervised and can be adapted with fine tuning to a wide range of natural language tasks, each of which previously would have required a separate network model. This is one step closer to the extraordinary versatility of human language. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Education] [Show ID: 38302]

Neuroscience has made great strides in the last decade following the Brain Research Through Advancing Innovative Neurotechnologies (BRAIN) Initiative, a science and engineering grand challenge that has greatly accelerated research on large-scale recordings from neurons and reconstructions of neural circuits. Large-scale neural network models have in turn inspired major advances in artificial intelligence. These network models have been trained on large-scale data sets to recognize objects in images, caption photographs, and translate text between languages. The most recent advance has been the emergence of pre-trained foundational language models that are self-supervised and can be adapted with fine tuning to a wide range of natural language tasks, each of which previously would have required a separate network model. This is one step closer to the extraordinary versatility of human language. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Education] [Show ID: 38302]

Neuroscience has made great strides in the last decade following the Brain Research Through Advancing Innovative Neurotechnologies (BRAIN) Initiative, a science and engineering grand challenge that has greatly accelerated research on large-scale recordings from neurons and reconstructions of neural circuits. Large-scale neural network models have in turn inspired major advances in artificial intelligence. These network models have been trained on large-scale data sets to recognize objects in images, caption photographs, and translate text between languages. The most recent advance has been the emergence of pre-trained foundational language models that are self-supervised and can be adapted with fine tuning to a wide range of natural language tasks, each of which previously would have required a separate network model. This is one step closer to the extraordinary versatility of human language. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Education] [Show ID: 38302]

Neuroscience has made great strides in the last decade following the Brain Research Through Advancing Innovative Neurotechnologies (BRAIN) Initiative, a science and engineering grand challenge that has greatly accelerated research on large-scale recordings from neurons and reconstructions of neural circuits. Large-scale neural network models have in turn inspired major advances in artificial intelligence. These network models have been trained on large-scale data sets to recognize objects in images, caption photographs, and translate text between languages. The most recent advance has been the emergence of pre-trained foundational language models that are self-supervised and can be adapted with fine tuning to a wide range of natural language tasks, each of which previously would have required a separate network model. This is one step closer to the extraordinary versatility of human language. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Education] [Show ID: 38302]

Huberman Lab Podcast Notes Key Takeaways Manic episodes are the defining criteria of bipolar disorder AKA bipolar depression – not all people with bipolar disorder experience deep depressionTypes of bipolar disorder: (1) Bipolar I – characterized by an extended period of mania (elevated mood, impulse, distractibility, etc.) – the mania is extreme and noticeable to people around; (2) Bipolar II – characterized by swings of hypomania (lessened intensity of mania or shorter duration of mania) and depressive episodesBipolar I presents itself more overtly because of bouts of mania; Bipolar II can duck under the radar because of the intense depressive state and hypomania which might look more normal compared to a depressive stateHeritability of bipolar disorder among the general population is 85% – if someone has bipolar disorder, it's likely they inherited a gene, set of genes, or susceptibility in genes to influences that can trigger bipolar disorderMajor neurological deficits in people with bipolar disorder: (1) lack of internal awareness (interoception); (2) top-down control on overall levels of energy (reduction in connectivity between parietal region and limbic system)Treatment approaches need to be comprehensive and in combination – for example, lithium + talk therapy“It's naïve and in fact, wrong, to say that lifestyle interventions alone are going to prevent especially extreme forms of mania and depression.” – Dr. Andrew HubermanRead the full notes @ podcastnotes.orgIn this episode, I explain the biology, symptoms, causes and types of bipolar disorder (sometimes called bipolar depression). I discuss neuroplasticity and how the brain normally regulates mood, energy, and perceptions; then, I contrast that with the biology of bipolar disorder, which is characterized by extremes of energy and mood, e.g., mania and depression. I outline the mechanisms through which bipolar disorder manifests in the brain, including deficits of interoception and reduced connections between the parietal and limbic systems. I also outline how treatment options (such as lithium) work in part through homeostatic plasticity.' I discuss not only lithium but also the treatment of bipolar with ketamine, different talk therapies, electroconvulsive therapy, transcranial magnetic stimulation, and nutraceuticals, including Omega-3 and Inositol supplementation. This episode should interest anyone who has or knows someone with bipolar disorder and, more broadly, those interested in how the brain works to create a balance between thoughts, energy levels, focus, and mood. Thank you to our sponsors InsideTracker: https://insidetracker.com/huberman ROKA: https://roka.com/huberman Blinkist: https://www.blinkist.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman. For the full show notes, visit hubermanlab.com. Timestamps (00:00:00) Bipolar Disorder (00:02:23) Momentous Supplements (00:03:42) Tool: Appetite Suppression & GLP-1, Parallel Pathways, Yerba Mate (00:10:23) InsideTracker, ROKA, Blinkist (00:14:24) Prevalence & Severity of Bipolar Disorder (00:16:30) Bipolar Disorder I, Diagnostic Criteria of Mania (00:28:58) Bipolar Disorder II, Individual Variability (00:33:07) Bipolar I vs. Bipolar II: Manic, Depressive & Symptom-Free States (00:38:20) Consequences of Bipolar Disorder, Heritability (00:46:53) Bipolar Disorder vs. Borderline Personality Disorder (00:51:51) Mania & Depression, Negative Impacts (00:53:06) History of Lithium Treatment (01:02:44) Lithium Treatment & Side-Effects (01:05:05) Effects of Lithium: BDNF, Anti-inflammatory & Neuroprotection (01:10:10) Neural Circuits of Bipolar Disorder, Interoception, Hyper- vs. Hypoactivity (01:17:11) Neural States & Mania, Parietal Lobe & Limbic System (01:22:58) Homeostatic Plasticity, Synaptic Scaling, Lithium & Ketamine (01:36:00) Talk Therapies: Cognitive Behavioral Therapy, Family-Focused Therapy, Interpersonal & Social Rhythm Therapy (01:43:18) Electroconvulsive Therapy (ECT), Transcranial Magnetic Stimulation (rTMS) (01:48:01) Psylocibin, Cannabis (01:51:50) Lifestyle Support, Supplements: Inositol & Omega-3 Fatty Acids (02:03:31) Omega-3s, Membrane Fluidity & Neuroplasticity (02:06:44) Mania, Creativity & Occupations (02:15:33) Bipolar Disorder: Diagnosis, Neural Circuits & Treatment (02:17:45) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, Instagram, Twitter, Neural Network Newsletter Title Card Photo Credit: Mike Blabac Disclaimer

In this episode, I explain the biology, symptoms, causes and types of bipolar disorder (sometimes called bipolar depression). I discuss neuroplasticity and how the brain normally regulates mood, energy, and perceptions; then, I contrast that with the biology of bipolar disorder, which is characterized by extremes of energy and mood, e.g., mania and depression. I outline the mechanisms through which bipolar disorder manifests in the brain, including deficits of interoception and reduced connections between the parietal and limbic systems. I also outline how treatment options (such as lithium) work in part through homeostatic plasticity.' I discuss not only lithium but also the treatment of bipolar with ketamine, different talk therapies, electroconvulsive therapy, transcranial magnetic stimulation, and nutraceuticals, including Omega-3 and Inositol supplementation. This episode should interest anyone who has or knows someone with bipolar disorder and, more broadly, those interested in how the brain works to create a balance between thoughts, energy levels, focus, and mood. Thank you to our sponsors InsideTracker: https://insidetracker.com/huberman ROKA: https://roka.com/huberman Blinkist: https://www.blinkist.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman. For the full show notes, visit hubermanlab.com. Timestamps (00:00:00) Bipolar Disorder (00:02:23) Momentous Supplements (00:03:42) Tool: Appetite Suppression & GLP-1, Parallel Pathways, Yerba Mate (00:10:23) InsideTracker, ROKA, Blinkist (00:14:24) Prevalence & Severity of Bipolar Disorder (00:16:30) Bipolar Disorder I, Diagnostic Criteria of Mania (00:28:58) Bipolar Disorder II, Individual Variability (00:33:07) Bipolar I vs. Bipolar II: Manic, Depressive & Symptom-Free States (00:38:20) Consequences of Bipolar Disorder, Heritability (00:46:53) Bipolar Disorder vs. Borderline Personality Disorder (00:51:51) Mania & Depression, Negative Impacts (00:53:06) History of Lithium Treatment (01:02:44) Lithium Treatment & Side-Effects (01:05:05) Effects of Lithium: BDNF, Anti-inflammatory & Neuroprotection (01:10:10) Neural Circuits of Bipolar Disorder, Interoception, Hyper- vs. Hypoactivity (01:17:11) Neural States & Mania, Parietal Lobe & Limbic System (01:22:58) Homeostatic Plasticity, Synaptic Scaling, Lithium & Ketamine (01:36:00) Talk Therapies: Cognitive Behavioral Therapy, Family-Focused Therapy, Interpersonal & Social Rhythm Therapy (01:43:18) Electroconvulsive Therapy (ECT), Transcranial Magnetic Stimulation (rTMS) (01:48:01) Psylocibin, Cannabis (01:51:50) Lifestyle Support, Supplements: Inositol & Omega-3 Fatty Acids (02:03:31) Omega-3s, Membrane Fluidity & Neuroplasticity (02:06:44) Mania, Creativity & Occupations (02:15:33) Bipolar Disorder: Diagnosis, Neural Circuits & Treatment (02:17:45) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, Instagram, Twitter, Neural Network Newsletter Title Card Photo Credit: Mike Blabac Disclaimer

Cori Bargmann, PhD, head of science at the Chan Zuckerberg Initiative, head of the Lulu and Anthony Wang Laboratory of Neural Circuits and Behavior, and the Torsten N. Wiesel Professor at The Rockefeller University, delivered the keynote address at UMass Chan Medical School's 49th Commencement. Listen to Dr. Bargmann's full speech in this episode of the Voices of UMass Chan. Learn more about Dr. Bargmann in this video: https://www.umassmed.edu/news/news-archives/2022/06/video-inside-the-lives-and-accomplishments-of-cori-bargmann-paula-johnson-and-james-oconnell/ Read more about Commencement: https://www.umassmed.edu/news/news-archives/2022/02/umass-chan-medical-school-to-celebrate-classes-of-2022-at-49th-commencement-on-june-5/

Huberman Lab Podcast Notes Key Takeaways Neural circuits (not individual brain areas) trigger aggressionAggression is not a switch, it's a process with a beginning, middle, and endAggression actually hinges on the hormone estrogenTestosterone in and of itself does not trigger aggression – testosterone aromatized into estrogen within the brain and binding to estrogen receptors in area of the brain that leads to aggressionEstrogen triggers aggression in brain and testosterone increases the pressure toward an aggressive episodeRecipe for aggression & reactivity: increased cortisol, reduced serotonin, short daysSelf-regulation is a key component of whether someone will engage in aggressive behaviorTools to reduce aggressive tendencies and impulsivity: pay attention to how daylight changes makes you feel, supplement with omega-3, supplement with ashwagandha in 2 week on/2week off cycles, get sunlight early in the day, try a hot bath or sauna, avoid beverages that contain both alcohol and caffeineRead the full notes @ podcastnotes.orgThis episode I describe the neural mechanisms that activate and control aggressive states and beahviors and the role of hormones—estrogen and testosterone—in mediating violent and and/or competive aggression. I also describe tools that can be used to modulate the factors that have been shown to ‘prime' an individual for aggression, including sunlight, estrogen sensitivity, competition within social settings, and overall stress levels, and the hormone cortisol. I discuss how substances such as caffeine and alcohol can impact impulsive behaviors, and how nutrition and supplementation can be used to regulate mood and aggression.  Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman ROKA: https://www.roka.com -- code: huberman Helix Sleep: https://www.helixsleep.com/huberman See Andrew Huberman Live: The Brain Body Contract https://hubermanlab.com/tour Our Patreon page https://www.patreon.com/andrewhuberman Supplements from Momentous https://www.livemomentous.com/huberman. For the full show notes, visit hubermanlab.com. Timestamps (00:00:00) Aggression, Types of Aggression (00:03:33) AG1 (Athletic Greens), ROKA, Helix Sleep (00:08:29) Neural Circuits for Aggression, “Hydraulic Pressure Model”  (00:15:50) Brain Regions Controlling Aggression, Ventromedial Hypothalamus (VMH)  (00:22:14) Psychiatric Disorders & Aggression  (00:23:36) Stimulation of the VMH, Estrogen Receptors & Aggression (00:31:57) Neural Circuits Mediating Physical Acts of Aggression, Biting (0:35:56) Testosterone & Competitiveness/Estrogen & Aggression  (00:43:00) Sunlight, Melatonin & Aggression  (00:45:46) Cortisol, Serotonin & Aggressive Behaviors  (00:51:56) Tool: Omega-3 Supplementation & Mood  (00:54:18) Tool: Sunlight, Sauna & Cortisol Reduction (00:55:54) Tool: Ashwagandha & Cortisol Reduction (00:57:06) Tool: Seasonality/Sunlight, Genetic Variation in Estrogen Sensitivity (01:00:37) Testosterone & Aggression, Competitive Work Environments (01:05:07) Testosterone, Amygdala, Challenge & Effort  (01:09:27) Caffeine, Alcohol & Impulsivity  (01:13:15) Tool: Caffeinated Alcohol Beverages, Impulsivity & Aggression  (01:17:18) Tool: ADHD, Acetyl-L Carnitine & Aggressive Behavior  (01:24:10) Factors Affecting the “Hydraulic Pressure Model” of Aggression  (01:25:44) Book by Dr. David Anderson, Aggression & Social Relationships  (01:27:35) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Patreon, Momentous Supplements, Neural Network Newsletter, Instagram, Twitter Title Card Photo Credit: Mike Blabac Disclaimer

This episode I describe the neural mechanisms that activate and control aggressive states and beahviors and the role of hormones—estrogen and testosterone—in mediating violent and and/or competive aggression. I also describe tools that can be used to modulate the factors that have been shown to ‘prime' an individual for aggression, including sunlight, estrogen sensitivity, competition within social settings, and overall stress levels, and the hormone cortisol. I discuss how substances such as caffeine and alcohol can impact impulsive behaviors, and how nutrition and supplementation can be used to regulate mood and aggression.  Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman ROKA: https://www.roka.com -- code: huberman Helix Sleep: https://www.helixsleep.com/huberman See Andrew Huberman Live: The Brain Body Contract https://hubermanlab.com/tour Our Patreon page https://www.patreon.com/andrewhuberman Supplements from Momentous https://www.livemomentous.com/huberman. For the full show notes, visit hubermanlab.com. Timestamps (00:00:00) Aggression, Types of Aggression (00:03:33) AG1 (Athletic Greens), ROKA, Helix Sleep (00:08:29) Neural Circuits for Aggression, “Hydraulic Pressure Model”  (00:15:50) Brain Regions Controlling Aggression, Ventromedial Hypothalamus (VMH)  (00:22:14) Psychiatric Disorders & Aggression  (00:23:36) Stimulation of the VMH, Estrogen Receptors & Aggression (00:31:57) Neural Circuits Mediating Physical Acts of Aggression, Biting (0:35:56) Testosterone & Competitiveness/Estrogen & Aggression  (00:43:00) Sunlight, Melatonin & Aggression  (00:45:46) Cortisol, Serotonin & Aggressive Behaviors  (00:51:56) Tool: Omega-3 Supplementation & Mood  (00:54:18) Tool: Sunlight, Sauna & Cortisol Reduction (00:55:54) Tool: Ashwagandha & Cortisol Reduction (00:57:06) Tool: Seasonality/Sunlight, Genetic Variation in Estrogen Sensitivity (01:00:37) Testosterone & Aggression, Competitive Work Environments (01:05:07) Testosterone, Amygdala, Challenge & Effort  (01:09:27) Caffeine, Alcohol & Impulsivity  (01:13:15) Tool: Caffeinated Alcohol Beverages, Impulsivity & Aggression  (01:17:18) Tool: ADHD, Acetyl-L Carnitine & Aggressive Behavior  (01:24:10) Factors Affecting the “Hydraulic Pressure Model” of Aggression  (01:25:44) Book by Dr. David Anderson, Aggression & Social Relationships  (01:27:35) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Patreon, Momentous Supplements, Neural Network Newsletter, Instagram, Twitter Title Card Photo Credit: Mike Blabac Disclaimer

For the low, low price of $15.95 on Amazon, you can purchase a little spray bottle of pheromones that supposedly will trigger "animal attraction" in your partner. But is it true??? Pheromones are a well-known system of communicating territory, alarms, and sexual needs to other animals but is this system present in humans? We know that smell is an important component of sexual attraction and arousal but human beings seem to lack both the organ and brain region needed to process pheromone information. But maybe???If you're curious, come and listen to learn a little bit more about what's happening upstairs!Please rate, review, and subscribe and if you have any questions, comments, concerns, queries, or complaints, please email me at neuroscienceamateurhour@gmail.com or DM me at NeuroscienceAmateurHour on Instagram.Citations and relevant pictures are below:Jimenez J, Hughes K, Alaks G, Graham L, Lacy R. An experimental study of inbreeding depression in a natural habitat. Science. 1994;266(5183):271-273. doi:10.1126/science.7939661Keverne EB. The Vomeronasal Organ. Science. 1999;286(5440):716-720. doi:10.1126/science.286.5440.716Kang N, Baum MJ, Cherry JA. Different Profiles of Main and Accessory Olfactory Bulb Mitral/Tufted Cell Projections Revealed in Mice Using an Anterograde Tracer and a Whole-Mount, Flattened Cortex Preparation. Chemical Senses. 2010;36(3):251-260. doi:10.1093/chemse/bjq120Wang L, Zhang Z, Chen J, et al. Cell-Type-Specific Whole-Brain Direct Inputs to the Anterior and Posterior Piriform Cortex. Frontiers in Neural Circuits. 2020;14. doi:10.3389/fncir.2020.00004‌Wedekind, C., Seebeck, T., Bettens, F. and Paepke, A. J. MHC-dependent mate preferences in humans. Proceedings of the Royal Society of London Series B. 1995: 260: 245-249Meredith M. Human Vomeronasal Organ Function: A Critical Review of Best and Worst Cases. Chemical Senses. 2001;26(4):433-445. doi:10.1093/chemse/26.4.433D'Aniello B, Semin GR, Scandurra A, Pinelli C. The Vomeronasal Organ: A Neglected Organ. Frontiers in Neuroanatomy. 2017;11. doi:10.3389/fnana.2017.00070Rodriguez I, Greer CA, Mok MY, Mombaerts P. A putative pheromone receptor gene expressed in human olfactory mucosa. Nature Genetics. 2000;26(1):18-19. doi:10.1038/79124Verhaeghe J, Gheysen R, Enzlin P. Pheromones and their effect on women's mood and sexuality. Facts, Views & Vision in ObGyn. 2013;5(3):189-195. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987372/Miller SL, Maner JK. Scent of a Woman. Psychological Science. 2009;21(2):276-283. doi:10.1177/0956797609357733Support the show (https://www.patreon.com/neuroscienceamateurhour)

Dr. Howard Schubiner is the director of the Mind Body Medicine Center at Ascension Providence Hospital in Southfield, Michigan. He is also a professor at the Michigan State University College of Human Medicine. He has multiple publications in scientific journals and books ranging from chronic pain to emotional awareness. Dr. Schubiner has consulted for the American Medical Association, the National Institute on Drug Abuse, and the National Institute on Mental Health. He is the author of multiple books, including Unlearn Your Pain, Unlearn Your Anxiety and Depression, and Hidden From View, written with Dr. Allan Abbass. Additionally, Dr. Schubiner has collaborated extensively with colleagues to develop two novel psychological treatments for chronic pain: Emotion Awareness and Expression Therapy (EAET) and Pain Reprocessing Therapy (PRT).   In today's episode, host Shay Beider speaks with Dr. Schubiner as he talks about the difference between neural circuit pain and structural pain. He describes how one's experience of pain is centered in the brain and can be the result of fear, stress or unprocessed emotions. Dr. Schubiner also shares some treatment methods he uses with patients. By understanding how the brain works and the importance of eliminating excess fear in the body, individuals are able to rewire neural feedback loops and change their pain response. Dr. Schubiner talks with Shay about how freeing this understanding can be for patients once they learn how to free their body and alleviate their pain. Listen to the complete episode by clicking the player above. Transcripts for this episode are available at: https://www.integrativetouch.org/conversations-on-healing    Show Notes: Find out more about Lisa Feldman Barett  Check out Anatomy of Hope by Jerome Groopman Learn more about the Sham Knee Surgery Study  Find out more about Terry Wahls Learn more about Adverse Childhood Experiences (ACEs)  Online Resources: Tension Myositis Peer Network Mobile App for Chronic Pain: https://www.curablehealth.com Learn more about helping chronic pain here: https://www.thedocjourney.com Freedom From Chronic Pain Psychophysiological Disorders Association Check our Dr. Schubiner's website: UnlearnYourPain Pain Psychology Center Personalized Pain Relief Program BackInControl Pain Relief in Simple Steps: here Book Resources: Healing Back Pain: The Mind Body Connection Unlearn Your Pain Unlearn Your Anxiety and Depression Hidden from View: A Clinician's guide to psychophysiological disorders Back in Control They Can't Find Anything Wrong Chronic Pain: Your Key to Recovery Documentary Films: All the Rage by Michael Gal This Might Hurt by Kent Bassett and Marion Cunningham This podcast was created by Integrative Touch (InTouch). InTouch is working to change the way people experience healthcare. A leader in the field of pediatric integrative medicine, the organization supports caregivers and families whose children have any type of special health or medical need. This includes kids with cancers, genetic conditions, autism, cerebral palsy, traumatic stress, and other serious health issues. The founder, Shay Beider, pioneered a new therapy called Integrative Touch™ Therapy that supports healing from trauma and serious illness. The organization reaches thousands of people each year in hospitals and communities and offers unique Telehealth programs to families and healthcare providers from around the world. Thanks to the incredible support of volunteers and contributors, individuals are able to receive wellness education and integrative medical services at little or no cost.

Psychiatrist Guido Frank, MD, joins Picture Blurrfect to discuss his lab's most recent paper in JAMA Psychiatry that sheds light on how eating disorder behavior can activate different circuits in the brain that control food intake. Naomi and Dr. Frank also talk about the importance of treating depression and anxiety concurrently with eating disorder behavior during treatment and recovery. Read more about Dr. Frank's work: https://profiles.ucsd.edu/guido.frank and view his most recent publication here: https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2781384Follow Picture Blurrent on social media!Twitter: @BlurrfectInstagram: @Picture_BlurrfectE-mail: naomi.charalambakis90@gmail.com

The paper we discuss is H Tyagi et al. (2019) A Randomized Trial Directly Comparing Ventral Capsule and Anteromedial Subthalamic Nucleus Stimulation in Obsessive-Compulsive Disorder: Clinical and Imaging Evidence for Dissociable Effects. Biological Psychiatry 85:726-734.You can find a copy of the Yale Brown Obsessive Compulsive Scale (Y-BOCS), complete with detailed instructions for administering the scale, here.A bit more information on the set-shifting/cognitive flexibility task used in the study can be found here.

How do neuroscientists tackle important questions about the brain? In this episode, Neuroscience PhD student Chiaki Santiago instils her wisdom about how we make discoveries about the brain, the nature vs. nurture debate, and common misconceptions we might have about the field. Discoveries about learning and memory in the brain may even be used to inform education policy - there's so much to unpack!If you want to learn more about the topics discussed in this episode, check out: So You Want to be a Neuroscientist? by Ashley Juavinett (book)"Experience-dependent structural synaptic plasticity in the mammalian brain" in Nature Reviews (scientific article)"Growing evidence of brain plasticity" by Michael Merzenich (TedTalk)Stories of WiN (Women in Neuroscience) Podcast: Episode with Brenda Bloodgood (podcast) Don't forget to follow us on Twitter @SpotlightThePod to stay up-to-date on all news and episode releases!Learn more about Northwestern University SPOT on Twitter @SPOTForceNU or at our website spot.northwestern.eduPodcast artwork created by Edie Jiang, available at her website https://ediejiang.weebly.com/ or on Instagram @ediejiangMusic in this episode: Earth by MusicbyAden https://soundcloud.com/musicbyadenCreative Commons — Attribution-ShareAlike 3.0 Unported — CC BY-SA 3.0Free Download / Stream: https://bit.ly/_earthMusic promoted by Audio Library https://youtu.be/5yIbZVOv438

Dr. Katherine Scangos, MD, PhD, is a psychiatrist and neuroscientist who focuses on circuit-level models of depression as an Assistant Professor at the University of California, San Francisco Department of Psychiatry. Her clinical work centers on interventional psychiatry. She co-directs the Transcranial Magnetic Stimulation and Neuromodulation clinic at UCSF. She also conducts quantitative neuroscience research on the development of electrophysiologic biomarkers in patients with mood disorders and works to develop new forms of brain stimulation therapies. Her goal is to translate these findings into a better understanding of neuropsychiatric illness and the development of novel therapeutics. She currently co-leads a clinical trial of personalized closed-loop deep brain stimulation in patients with depression. Dr. Scangos is a recipient of the National Institute of Mental Health's Outstanding Resident Award Program in 2017. She currently receives funding from the Brain and Behavioral Research Foundation NARSAD Young Investigator Grant and from the National Institute of Neurological Disorders. She received her medical degree and a doctorate in neuroscience from Johns Hopkins School of Medicine (MD/PhD). She subsequently completed a psychiatry residency at the University of California, Davis, and a fellowship in Interventional Psychiatry at the University of California, San Francisco.