POPULARITY
13 episodes with neural development
13 episodes with neural development
13 episodes with neural development
4 episodes with neural development
2 episodes with neural development
3 episodes with neural development
2 episodes with neural development
In this episode of the Epigenetics Podcast, we talked with Tanja Vogel from the University Clinics Freiburg about her work on epigenetic modifications in stem cells during central nervous system development. During our discussion, Dr. Vogel shared that she and her team have investigated H3K79 methylation and its functional significance, which remains a topic of debate in the scientific community. They've also investigated the role of DOT1L in neural development and its implications for neuronal networks, as disrupting DOT1L can lead to conditions such as epilepsy and schizophrenia. They explored the function of the SOX2 enhancer in the presence or absence of DOT1L enzymatic inhibition. The conversation then shifts to FoxG1, a vital player in forebrain development. The team uncovered its role in chromatin accessibility and its connection to microRNA processing. Their study, utilizing ChIP-Seq, reveals FoxG1's interactions with enhancer regions and other transcription factors, like NeuroD1. ### References Britanova, O., de Juan Romero, C., Cheung, A., Kwan, K. Y., Schwark, M., Gyorgy, A., Vogel, T., Akopov, S., Mitkovski, M., Agoston, D., Sestan, N., Molnár, Z., & Tarabykin, V. (2008). Satb2 is a postmitotic determinant for upper-layer neuron specification in the neocortex. Neuron, 57(3), 378–392. https://doi.org/10.1016/j.neuron.2007.12.028 Büttner, N., Johnsen, S. A., Kügler, S., & Vogel, T. (2010). Af9/Mllt3 interferes with Tbr1 expression through epigenetic modification of histone H3K79 during development of the cerebral cortex. Proceedings of the National Academy of Sciences of the United States of America, 107(15), 7042–7047. https://doi.org/10.1073/pnas.0912041107 Franz, H., Villarreal, A., Heidrich, S., Videm, P., Kilpert, F., Mestres, I., Calegari, F., Backofen, R., Manke, T., & Vogel, T. (2019). DOT1L promotes progenitor proliferation and primes neuronal layer identity in the developing cerebral cortex. Nucleic acids research, 47(1), 168–183. https://doi.org/10.1093/nar/gky953 Ferrari, F., Arrigoni, L., Franz, H., Izzo, A., Butenko, L., Trompouki, E., Vogel, T., & Manke, T. (2020). DOT1L-mediated murine neuronal differentiation associates with H3K79me2 accumulation and preserves SOX2-enhancer accessibility. Nature communications, 11(1), 5200. https://doi.org/10.1038/s41467-020-19001-7 Akol, I., Izzo, A., Gather, F., Strack, S., Heidrich, S., Ó hAilín, D., Villarreal, A., Hacker, C., Rauleac, T., Bella, C., Fischer, A., Manke, T., & Vogel, T. (2023). Multimodal epigenetic changes and altered NEUROD1 chromatin binding in the mouse hippocampus underlie FOXG1 syndrome. Proceedings of the National Academy of Sciences of the United States of America, 120(2), e2122467120. https://doi.org/10.1073/pnas.2122467120 Related Episodes Molecular Mechanisms of Chromatin Modifying Enzymes (Karim-Jean Armache) Contact Epigenetics Podcast on Twitter Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Active Motif on Twitter Active Motif on LinkedIn Email: podcast@activemotif.com
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.10.17.512465v1?rss=1 Authors: De Schutter, E. Abstract: The Neural Development Simulator, NeuroDevSim, is a Python module that simulates the most important aspects of development: growth, migration and pruning. It uses an agent-based modeling approach inherited from the NeuroMaC software. Each cycle, agents called fronts execute code. In the case of a growing dendritic or axonal front this will be a choice between extension, branching or growth termination. Somatic fronts can migrate to new positions and any front can be retracted to prune parts of neurons. NeuroDevSim is a multi-core program that uses an innovative shared memory approach to achieve parallel processing without messaging. We demonstrate close to linear strong scaling for medium size models for up to 32 cores and have run large models successfully on 128 cores. Most of the shared memory parallelism is achieved without memory locking. Instead cores have write privileges to private sections of arrays only, while being able to read the entire shared array. Memory conflicts are avoided by a coding rule that allows only active fronts to use methods that need writing access. The exception is collision detection, which is needed to avoid growth of physically overlapping structures. Here a locking mechanism was necessary to control access to grid points that register the location of nearby fronts. A custom approach using a serialized lock broker was able to manage both read and write locking. NeuroDevSim allows easy modeling of neural development for models ranging from a few complex to thousands of simple neurons or a mixture of both. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Dr. Agnete Kirkeby is an Associate Professor at the University of Copenhagen and a Group Leader at Lund University. The Kirkeby group studies the factors involved in human neural subtype specification in order to enable production of specific neurons for understanding and treating neurological diseases. They apply advanced human stem cells models to understand how hundreds of human neuronal subtypes are formed during embryo development. She talks about moving stem cell therapies for Parkinson's disease from animal models to clinical trials, modeling neural tube development, and developing treatments for narcolepsy.
Exploring cellular anthropology to understand how variation in human regulatory elements can mediate morphological evolution and individual variation of the craniofacial form. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32973]
Exploring cellular anthropology to understand how variation in human regulatory elements can mediate morphological evolution and individual variation of the craniofacial form. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32973]
Exploring cellular anthropology to understand how variation in human regulatory elements can mediate morphological evolution and individual variation of the craniofacial form. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32973]
Exploring cellular anthropology to understand how variation in human regulatory elements can mediate morphological evolution and individual variation of the craniofacial form. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32973]
Exploring cellular anthropology to understand how variation in human regulatory elements can mediate morphological evolution and individual variation of the craniofacial form. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32973]
Exploring cellular anthropology to understand how variation in human regulatory elements can mediate morphological evolution and individual variation of the craniofacial form. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32973]
Explores cellular anthropology to understand how variation in human regulatory elements can mediate morphological evolution and individual variation of the craniofacial form. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32973]
Explores cellular anthropology to understand how variation in human regulatory elements can mediate morphological evolution and individual variation of the craniofacial form. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32973]
Dr. Marion Van Horn is a Research Associate at the Montreal Neurological Institute whose work focuses on brain development, developmental plasticity, and synaptic pruning. She is also a mom of three, and as a mom, she has some amazing techniques for supporting your kids’ brain development. We also dive into how we can protect ourselves and our families from COVID-19. You will learn about... What Dr. Marion researches in her lab What neuroplasticity is and how to support it within children The importance of play for kids The benefits of lowering expectations How much time we need to spend outside Getting enough sleep and sticking to a routine Improving synaptic pruning The role of nutrition in cognitive development How we can support ourselves against COVID-19 during pregnancy Resources: LinkedIn: https://www.linkedin.com/in/marion-van-horn-phd-b937b35/ (linkedin.com/in/marion-van-horn-phd-b937b35) Twitter: https://twitter.com/marionvanhorn (@marionvanhorn) Read: https://www.goodreads.com/book/show/34466963-why-we-sleep ("Why We Sleep") Connect with Kelly: https://kellyleveque.com/ (kellyleveque.com) Instagram: https://www.instagram.com/bewellbykelly/ (@bewellbykelly) Facebook: https://www.facebook.com/bewellbykelly/ (www.facebook.com/bewellbykelly) Be Well By Kelly is a production of http://crate.media (Crate Media)
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.21.261669v1?rss=1 Authors: Khakhalin, A. S., Aizenman, C. D., Lopez, V. Abstract: Escape responses, orienting reflexes, and social behaviors in Xenopus laevis tadpoles have been well documented in the literature (Lee et al. 2010; Roberts et al. 2000; Simmons et al. 2004; Katz et al. 1981; Villinger and Waldman 2012). In this article, we describe several behavioral protocols that together allow researchers efficiently (in terms of financial cost and time investment) and effectively assess developmental abnormalities in pre-metamorphic Xenopus tadpoles. Copy rights belong to original authors. Visit the link for more info
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.07.241208v1?rss=1 Authors: Dapergola, E., Menegazzi, P., Raabe, T., Hovhanyan, A. Abstract: Endogenous clocks enable organisms to adapt their physiology and behavior to daily variation in environmental conditions. Metabolic processes in cyanobacteria to humans are effected by the circadian clock, and its dysregulation causes metabolic disorders. In mouse and Drosophila were shown that the circadian clock directs translation of factors involved in ribosome biogenesis and synchronizes protein synthesis. However, the role of clocks in Drosophila neurogenesis and the potential impact of clock impairment on neural circuit formation and function is less understood. Here we demonstrate that light stimuli or circadian clock causes a defect in neural stem cell growth and proliferation accompanied by reduced nucleolar size. Further, we define that light and clock independently affect the InR/TOR growth regulatory pathway due to the effect on regulators of protein biosynthesis. Altogether, these data suggest that alterations in growth regulatory pathways induced by light and clock are associated with impaired neural development. Copy rights belong to original authors. Visit the link for more info
The search for human-specific genome changes underlying the unique neocortex expansion found only in the human brain. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32971]
CARTA - Center for Academic Research and Training in Anthropogeny (Video)
The search for human-specific genome changes underlying the unique neocortex expansion found only in the human brain. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32971]
CARTA - Center for Academic Research and Training in Anthropogeny (Audio)
The search for human-specific genome changes underlying the unique neocortex expansion found only in the human brain. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32971]
The search for human-specific genome changes underlying the unique neocortex expansion found only in the human brain. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32971]
The search for human-specific genome changes underlying the unique neocortex expansion found only in the human brain. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32971]
The search for human-specific genome changes underlying the unique neocortex expansion found only in the human brain. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32971]
The search for human-specific genome changes underlying the unique neocortex expansion found only in the human brain. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32971]
The search for human-specific genome changes underlying the unique neocortex expansion found only in the human brain. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32971]
------------------Support the channel------------ Patreon: https://www.patreon.com/thedissenter PayPal: paypal.me/thedissenter ------------------Follow me on--------------------- Facebook: https://www.facebook.com/thedissenteryt/ Twitter: https://twitter.com/TheDissenterYT Dr. Dale Purves is Geller Professor of Neurobiology Emeritus at the Center for Cognitive Neuroscience, at Duke University. He was elected to the National Academy of Sciences in 1989 for his work on neural development and synaptic plasticity. He is a fellow of the American Academy of Arts and Sciences and the National Academy of Medicine. He is the author of many books, including Principles of Neural Development, and Brains: How they Seem to Work, and also the lead author on the textbooks Neuroscience, and Principles of Cognitive Neuroscience. His research during the last 15 years has sought to explain why we see and hear what we do, focusing on the visual perception of lightness, color, form, and motion, and the auditory perception of music and speech. In this episode, we talk how perception evolved and works; how our cognitive systems have an innate structural organization, but also allow for neuroplasticity at the same time; what are illusions; if there's any direct relation between conscious perception and the production of behavior, as when we're driving and thinking about something, and not consciously aware of our surroundings; understanding perception in wholly empirical terms; and the proper way to look at the relationship between perception and reality as such. Time Links: 01:08 The evolutionary basis of perception 07:09 Do our brains make inferences based on limited information? 08:48 How do we combine innate structural organization with neuroplasticity? 10:46 Our brains contain innate information in the way they're structured 12:57 Fixed action patterns, or “instincts” 13:52 Are illusions errors in cognition? 16:08 Is there any direct relation between conscious perception and the production of behavior? 18:36 Understanding vision (and perception) in wholly empirical terms 22:30 Putting aside the distinction between “reality as such” and our experience of reality 24:59 What is “real”? 26:46 Follow Dr. Purves' work! -- Follow Dr. Purves' work: Purves Lab: http://purveslab.net/ Faculty page: https://dibs.duke.edu/scholars/dale-purves Books: https://tinyurl.com/yc7etryp -- A HUGE THANK YOU TO MY PATRONS: KARIN LIETZCKE, ANN BLANCHETTE, JUNOS, SCIMED, PER HELGE HAAKSTD LARSEN, LAU GUERREIRO, RUI BELEZA, MIGUEL ESTRADA, ANTÓNIO CUNHA, CHANTEL GELINAS, JIM FRANK, JERRY MULLER, FRANCIS FORD, AND HANS FREDRIK SUNDE! I also leave you with the link to a recent montage video I did with the interviews I have released until the end of June 2018: https://youtu.be/efdb18WdZUo And check out my playlists on: PSYCHOLOGY: https://tinyurl.com/ybalf8km PHILOSOPHY: https://tinyurl.com/yb6a7d3p ANTHROPOLOGY: https://tinyurl.com/y8b42r7g
Tracing evolution through past genomic events. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32974]
Tracing evolution through past genomic events. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32974]
Tracing evolution through past genomic events. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32974]
CARTA - Center for Academic Research and Training in Anthropogeny (Audio)
Tracing evolution through past genomic events. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32974]
Tracing evolution through past genomic events. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32974]
CARTA - Center for Academic Research and Training in Anthropogeny (Video)
Tracing evolution through past genomic events. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32974]
CARTA - Center for Academic Research and Training in Anthropogeny (Video)
Exploring cellular features of human brain development that are not represented in animal models and may reflect human or primate-specific evolutionary adaptations and how they also provide a roadmap for interpreting laboratory models of human brain development and evolution. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32972]
Exploring cellular features of human brain development that are not represented in animal models and may reflect human or primate-specific evolutionary adaptations and how they also provide a roadmap for interpreting laboratory models of human brain development and evolution. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32972]
CARTA - Center for Academic Research and Training in Anthropogeny (Audio)
Exploring cellular features of human brain development that are not represented in animal models and may reflect human or primate-specific evolutionary adaptations and how they also provide a roadmap for interpreting laboratory models of human brain development and evolution. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32972]
Exploring cellular features of human brain development that are not represented in animal models and may reflect human or primate-specific evolutionary adaptations and how they also provide a roadmap for interpreting laboratory models of human brain development and evolution. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32972]
Exploring cellular features of human brain development that are not represented in animal models and may reflect human or primate-specific evolutionary adaptations and how they also provide a roadmap for interpreting laboratory models of human brain development and evolution. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32972]
Exploring cellular features of human brain development that are not represented in animal models and may reflect human or primate-specific evolutionary adaptations and how they also provide a roadmap for interpreting laboratory models of human brain development and evolution. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32972]
Exploring the use of primate stem cell systems to understand the cellular and molecular mechanisms underlying species differences in cerebral cortex development. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32970]
Exploring the use of primate stem cell systems to understand the cellular and molecular mechanisms underlying species differences in cerebral cortex development. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32970]
CARTA - Center for Academic Research and Training in Anthropogeny (Video)
Exploring the use of primate stem cell systems to understand the cellular and molecular mechanisms underlying species differences in cerebral cortex development. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32970]
Exploring the use of primate stem cell systems to understand the cellular and molecular mechanisms underlying species differences in cerebral cortex development. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32970]
Exploring the use of primate stem cell systems to understand the cellular and molecular mechanisms underlying species differences in cerebral cortex development. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32970]
CARTA - Center for Academic Research and Training in Anthropogeny (Audio)
Exploring the use of primate stem cell systems to understand the cellular and molecular mechanisms underlying species differences in cerebral cortex development. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32970]
CARTA - Center for Academic Research and Training in Anthropogeny (Video)
This presentation provides a cellular and molecular analysis of comparative neural development in closely related hominids, which opens new avenues for understanding the differences in the neural underpinnings of cognition and neurological disease susceptibility between species. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32969]
This presentation provides a cellular and molecular analysis of comparative neural development in closely related hominids, which opens new avenues for understanding the differences in the neural underpinnings of cognition and neurological disease susceptibility between species. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32969]
CARTA - Center for Academic Research and Training in Anthropogeny (Audio)
This presentation provides a cellular and molecular analysis of comparative neural development in closely related hominids, which opens new avenues for understanding the differences in the neural underpinnings of cognition and neurological disease susceptibility between species. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32969]
This presentation provides a cellular and molecular analysis of comparative neural development in closely related hominids, which opens new avenues for understanding the differences in the neural underpinnings of cognition and neurological disease susceptibility between species. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32969]
CARTA - Center for Academic Research and Training in Anthropogeny (Audio)
New insights into the significance of the emergence of a human-specific gene on brain evolution. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32975]
New insights into the significance of the emergence of a human-specific gene on brain evolution. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32975]
New insights into the significance of the emergence of a human-specific gene on brain evolution. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32975]
CARTA - Center for Academic Research and Training in Anthropogeny (Video)
New insights into the significance of the emergence of a human-specific gene on brain evolution. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32975]
Huxley and Darwin were among the first to appreciate the close evolutionary relationship of humans and other African great apes but also to ponder what genetic changes might make us human. Initial comparisons of human and chimpanzee genes, showed little difference (>99% identical) despite the numerous adaptations that must have occurred on the human lineage. Recent studies of more complex regions of our genome have revealed hotspots of dramatic evolutionary change. Within these regions are hundreds of new duplicate genes, several of which appear to be important in human-specific neuroanatomical adaptations. Paradoxically, this genetic complexity has led to mutations causing childhood diseases suggesting that human-specific genes and increased disease burden are tightly linked. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32976]
CARTA - Center for Academic Research and Training in Anthropogeny (Audio)
Huxley and Darwin were among the first to appreciate the close evolutionary relationship of humans and other African great apes but also to ponder what genetic changes might make us human. Initial comparisons of human and chimpanzee genes, showed little difference (>99% identical) despite the numerous adaptations that must have occurred on the human lineage. Recent studies of more complex regions of our genome have revealed hotspots of dramatic evolutionary change. Within these regions are hundreds of new duplicate genes, several of which appear to be important in human-specific neuroanatomical adaptations. Paradoxically, this genetic complexity has led to mutations causing childhood diseases suggesting that human-specific genes and increased disease burden are tightly linked. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32976]
Huxley and Darwin were among the first to appreciate the close evolutionary relationship of humans and other African great apes but also to ponder what genetic changes might make us human. Initial comparisons of human and chimpanzee genes, showed little difference (>99% identical) despite the numerous adaptations that must have occurred on the human lineage. Recent studies of more complex regions of our genome have revealed hotspots of dramatic evolutionary change. Within these regions are hundreds of new duplicate genes, several of which appear to be important in human-specific neuroanatomical adaptations. Paradoxically, this genetic complexity has led to mutations causing childhood diseases suggesting that human-specific genes and increased disease burden are tightly linked. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32976]
CARTA - Center for Academic Research and Training in Anthropogeny (Video)
Huxley and Darwin were among the first to appreciate the close evolutionary relationship of humans and other African great apes but also to ponder what genetic changes might make us human. Initial comparisons of human and chimpanzee genes, showed little difference (>99% identical) despite the numerous adaptations that must have occurred on the human lineage. Recent studies of more complex regions of our genome have revealed hotspots of dramatic evolutionary change. Within these regions are hundreds of new duplicate genes, several of which appear to be important in human-specific neuroanatomical adaptations. Paradoxically, this genetic complexity has led to mutations causing childhood diseases suggesting that human-specific genes and increased disease burden are tightly linked. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32976]
The way cells differentiate to eventually form the human brain and all the unique connections that make us human is ultimately the result of processes forged in evolution. Three experts share their investigations into characteristics of the human genome and its changes throughout evolution that make us human. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32928]
CARTA - Center for Academic Research and Training in Anthropogeny (Video)
The way cells differentiate to eventually form the human brain and all the unique connections that make us human is ultimately the result of processes forged in evolution. Three experts share their investigations into characteristics of the human genome and its changes throughout evolution that make us human. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32928]
The way cells differentiate to eventually form the human brain and all the unique connections that make us human is ultimately the result of processes forged in evolution. Three experts share their investigations into characteristics of the human genome and its changes throughout evolution that make us human. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32928]
CARTA - Center for Academic Research and Training in Anthropogeny (Audio)
The way cells differentiate to eventually form the human brain and all the unique connections that make us human is ultimately the result of processes forged in evolution. Three experts share their investigations into characteristics of the human genome and its changes throughout evolution that make us human. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32928]
Concluding remarks and question and answer session for the symposium: Cellular and Molecular Explorations of Anthropogeny. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32978]
Welcome and introductory remarks to the symposium: Cellular and Molecular Explorations of Anthropogeny Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32977]
Exploring cellular anthropology to understand how variation in human regulatory elements can mediate morphological evolution and individual variation of the craniofacial form. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32973]
CARTA - Center for Academic Research and Training in Anthropogeny (Video)
Exploring cellular anthropology to understand how variation in human regulatory elements can mediate morphological evolution and individual variation of the craniofacial form. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32973]
CARTA - Center for Academic Research and Training in Anthropogeny (Video)
Welcome and introductory remarks to the symposium: Cellular and Molecular Explorations of Anthropogeny Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32977]
CARTA - Center for Academic Research and Training in Anthropogeny (Audio)
Concluding remarks and question and answer session for the symposium: Cellular and Molecular Explorations of Anthropogeny. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32978]
Concluding remarks and question and answer session for the symposium: Cellular and Molecular Explorations of Anthropogeny. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32978]
CARTA - Center for Academic Research and Training in Anthropogeny (Audio)
Welcome and introductory remarks to the symposium: Cellular and Molecular Explorations of Anthropogeny Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32977]
CARTA - Center for Academic Research and Training in Anthropogeny (Video)
Concluding remarks and question and answer session for the symposium: Cellular and Molecular Explorations of Anthropogeny. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32978]
Exploring cellular anthropology to understand how variation in human regulatory elements can mediate morphological evolution and individual variation of the craniofacial form. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32973]
CARTA - Center for Academic Research and Training in Anthropogeny (Audio)
Exploring cellular anthropology to understand how variation in human regulatory elements can mediate morphological evolution and individual variation of the craniofacial form. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32973]
Welcome and introductory remarks to the symposium: Cellular and Molecular Explorations of Anthropogeny Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32977]
CARTA - Center for Academic Research and Training in Anthropogeny (Video)
The human brain is one of, if not the most important factor that distinguishes our species from all others. Three experts explore the use of stem cells in understanding the primate brain, genes that guided the evolution of the human brain, and the features that enabled the expansion of human neural characteristics. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32927]
The human brain is one of, if not the most important factor that distinguishes our species from all others. Three experts explore the use of stem cells in understanding the primate brain, genes that guided the evolution of the human brain, and the features that enabled the expansion of human neural characteristics. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32927]
The human brain is one of, if not the most important factor that distinguishes our species from all others. Three experts explore the use of stem cells in understanding the primate brain, genes that guided the evolution of the human brain, and the features that enabled the expansion of human neural characteristics. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32927]
The human brain is one of, if not the most important factor that distinguishes our species from all others. Three experts explore the use of stem cells in understanding the primate brain, genes that guided the evolution of the human brain, and the features that enabled the expansion of human neural characteristics. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32927]
The human brain is one of, if not the most important factor that distinguishes our species from all others. Three experts explore the use of stem cells in understanding the primate brain, genes that guided the evolution of the human brain, and the features that enabled the expansion of human neural characteristics. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32927]
CARTA - Center for Academic Research and Training in Anthropogeny (Audio)
The human brain is one of, if not the most important factor that distinguishes our species from all others. Three experts explore the use of stem cells in understanding the primate brain, genes that guided the evolution of the human brain, and the features that enabled the expansion of human neural characteristics. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32927]
The Salk Institute's Rusty Gage and University of Washington's Evan Eichler explore the mechanisms and evolutionary pathways that have differentiated human neural development and allowed for the emergence of genes found only in humans. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32926]
The Salk Institute's Rusty Gage and University of Washington's Evan Eichler explore the mechanisms and evolutionary pathways that have differentiated human neural development and allowed for the emergence of genes found only in humans. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32926]
CARTA - Center for Academic Research and Training in Anthropogeny (Video)
The Salk Institute's Rusty Gage and University of Washington's Evan Eichler explore the mechanisms and evolutionary pathways that have differentiated human neural development and allowed for the emergence of genes found only in humans. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32926]
CARTA - Center for Academic Research and Training in Anthropogeny (Audio)
The Salk Institute's Rusty Gage and University of Washington's Evan Eichler explore the mechanisms and evolutionary pathways that have differentiated human neural development and allowed for the emergence of genes found only in humans. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32926]
The publisher's latest virtual reality project aims to show audiences the importance of responsive care and social interaction during their first year of life
Dr. Brock Grill is an Associate Professor in the Department of Neuroscience at the Scripps Research Institute in Florida. He received his B.Sc. in Microbiology from the University of Alberta and was awarded his Ph.D. in Experimental Medicine from the University of British Columbia. Brock conducted postdoctoral research at the University of California Santa Cruz and at Stanford University. He served on the faculty at the University of Minnesota Medical School before joining the faculty at Scripps - Florida. Brock is here with us today to tell us all about his journey through life and science.
Mon, 25 Nov 2013 20:33:48 GMT https://sakai.rutgers.edu/access/content/group/c7b3269a-bc92-488e-b4b1-0e20648073af/Podcasts
Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 13/19
Tue, 31 Jan 2012 12:00:00 +0100 https://edoc.ub.uni-muenchen.de/13954/ https://edoc.ub.uni-muenchen.de/13954/1/Nieberler_Markus.pdf Nieberler, Markus ddc:610,
From the 2006 Clinical Implications of Environmental Toxicology for Children's Neurodevelopment in Autism Conference. Recorded Thu, 02 Nov 2006 10:15:00 PST.
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.04.22.055731v1?rss=1 Authors: Roth, J. G., Muench, K. L., Asokan, A., Mallett, V. M., Gai, H., Verma, Y., Weber, S., Charlton, C., Fowler, J. L., Loh, K. M., Dolmetsch, R. E., Palmer, T. D. Abstract: Microdeletions and microduplications of the 16p11.2 chromosomal locus are associated with syndromic neurodevelopmental disorders and reciprocal physiological conditions such as macro/microcephaly and high/low body mass index. To facilitate cellular and molecular investigations of these phenotypes, 65 clones of human induced pluripotent stem cells (hiPSCs) were generated from 13 individuals with 16p11.2 copy number variations (CNVs). Cortical neural progenitor cells derived from these hiPSCs were profiled using RNA-Seq, which identified alterations in radial glial gene expression that precede morphological abnormalities reported at later neurodevelopmental stages. Moreover, a customizable bioinformatic strategy for the detection of random integration and expression of reprogramming vectors was developed and leveraged towards identifying a subset of footprint-free hiPSC clones that are available by request from the Simons Foundation Autism Research Initiative. This publicly available resource of 65 human hiPSC clones can serve as a powerful medium for probing the etiology of developmental disorders associated with 16p11.2 CNVs Copy rights belong to original authors. Visit the link for more info
© 2020-2025 Ivy Podcast Discovery LLC
