Podcasts about molecular mechanisms

Você já ouviu falar de galhas vegetais? Separe trinta minutinhos do seu dia e descubra, com Mila Massuda, o que são galhas, como se desenvolvem e como pequenos organismos conseguem manipular o crescimento das plantas para criar verdadeiras estruturas vivas sob medida para eles!Apresentação: Mila Massuda (@milamassuda)Roteiro: Mila Massuda (@milamassuda) e Emilio Garcia (@emilioblablalogia)Revisão de Roteiro: Vee Almeida e Caio de Santis (@caiodesantis)Técnica de Gravação: Julianna Harsche (@juvisharsche)Editora: Lilian Correa (@_lilianleme)Mixagem e Masterização: Lívia Mello (@adiscolizard) Produção: Prof. Vítor Soares (@profvitorsoares), Matheus Herédia (@Matheus_Heredia) e BláBláLogia (@blablalogia) e Biologia em Meia Hora (@biologiaemmeiahora)Gravado e editado nos estúdios TocaCast, do grupo Tocalivros (@tocalivros)REFERÊNCIASHARRIS, M. O.; PITZSCHKE, A. Plants make galls to accommodate foreigners: some are friends, most are foes. New Phytologist, v. 225, n. 5, p. 1852–1872, 6 jan. 2020.IKEUCHI, M. et al. Molecular Mechanisms of Plant Regeneration. Annual Review of Plant Biology, v. 70, n. 1, p. 377–406, 29 abr. 2019.REDFERN, M. Plant Galls (Collins New Naturalist Library, Book 117). [s.l.] HarperCollins UK, 2011.

Dr. Karine Gaelle Le Roch is a Professor in the Department of Molecular, Cell and Systems Biology and Director of the Center for Infectious Disease and Vector Research at the University of California, Riverside. Karine's research focuses on parasites, and much of her work has focused on the parasite that causes malaria in humans. She is working to better understand the life cycle of the parasite, how the molecular components in its body work together, and how the parasite's function can be disrupted after a person has been infected in order to treat and cure malaria. When she's not doing science, Karine enjoys sailing in the San Diego Bay, skiing in the winter, spending time with her son, and watching him play soccer. She received her BA in Biochemistry and Microbiology from the University Paris-Sorbonne, her MS in host-parasite interactions between Oxford University in the UK and the University of Lille in France, and her PhD in Parasitology and host-parasite interactions from the University Paris-Sorbonne. Afterwards, she conducted postdoctoral research at The Scripps Research Institute in La Jolla and subsequently she was an Institute Fellow at the Genomics Institute of the Novartis Research Foundation. Karine joined the faculty at UCR in 2006. She has earned various honors and awards throughout her career, including the Academic Senate Regent Award for Outstanding Research from the University of California, she was a participant in the Provost Faculty Leadership Program at UCR and the University of California's Women's Initiative for Professional Development. In our interview, Karine shares more about her life and science.

CME credits: 0.50 Valid until: 18-10-2025 Claim your CME credit at https://reachmd.com/programs/cme/molecular-mechanisms-of-copd/27033/ Although chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death worldwide, current management does not alter progression of the disease. With the potential for biologically-targeted therapies to be available soon, it is important to address current educational needs related to COPD. This includes knowledge of T2 inflammation in COPD, understanding the clinician's role in assessing patients for inflammatory types, staying in formed about developing therapies, and adopting strategies that shift COPD management to a more personalized approach.

Brilhar no escuro é sinônimo de bioluminescência? Quais as funções da bioluminescência na ecologia? Quais organismos apresentam essa característica?     SciCast na Campus Party São Paulo 2024:   Utilize o cupom #SCICAST para comprar seu ingresso na página da CPBR16 Patronato do SciCast: 1. Patreon SciCast 2. Apoia.se/Scicast     3. Nos ajude via Pix também, chave: contato@scicast.com.br ou acesse o QRcode:   Sua pequena contribuição ajuda o Portal Deviante a continuar divulgando Ciência! Contatos: contato@scicast.com.br https://twitter.com/scicastpodcast https://www.facebook.com/scicastpodcast https://instagram.com/scicastpodcast Fale conosco! E não esqueça de deixar o seu comentário na postagem desse episódio! Expediente: Produção Geral: Tarik Fernandes e André Trapani Equipe de Gravação: André Trapani, Caio Ferreira, Rita Kujawski, Marcelo de Matos, Ramon Carollo Sarabia Neto Citação ABNT: Scicast #599: Bioluminescência. Locução: André Trapani, Caio Ferreira, Rita Kujawski, Marcelo de Matos, Ramon Carollo Sarabia Neto. [S.l.] Portal Deviante, 05/06/2024. Podcast. Disponível em: https://www.deviante.com.br/podcasts/scicast-599 Arte:  Referências e Indicações Coelenterazine The Glow-In-The-Dark Kitty Oceanic Bioluminescence: an Overview of General Functions Bioluminescence Chemistry of bioluminescence The Chemistry of Bioluminescence Bioluminescence Functions of bioluminescence Molecular Mechanisms of Bacterial Bioluminescence Radiative DecaySee omnystudio.com/listener for privacy information.

At our second scientific breakfast, we had the pleasure of meeting Zdeněk Andrysík, the new head of the research group "Molecular Mechanisms of Cancer" at the Department of Biology, Faculty of Medicine MU. He shared his personal experiences and valuable insights on navigating and thriving in the world of research. His journey overseas began with a desire to expand his horizons and continue his research in a postdoctoral position abroad. During the conversation he compared the research infrastructure of laboratories at MU and in the United States and also he shared his plans to expand his research group to include undergraduate students in the future.

There are many reliable and unreliable symptoms of thyroid issues that can be confusing to those trying to understand how to improve their health. In this episode, I identify the top warning signs and symptoms of thyroid issues that you should not ignore, and resources to help guide you towards healing. Watch now! Take the Thyroid Course! https://drruscio.com/thyroid-course/ Grab Your Thyroid 101 Handout: https://drruscio.com/thyroid-health-101/

Dr. Kartik Sunagar, Ph.D. is Associate Professor and Group Leader of the Evolutionary Venomics Lab ( https://www.venomicslab.com/members ) at the Centre for Ecological Sciences (CES), Indian Institute of Science (IISC), where his team investigates venomous animals and their venoms as model systems to address basic but broad questions in evolutionary biology and genetics. Dr. Sunagar is an evolutionary geneticist, and a major focus of his research has been on innovating pan-India efficacious snakebite therapies through the discovery and development of broadly neutralizing antibodies. Dr. Sunagar's Ph.D. (University of Porto, Portugal) and postdoctoral research (Hebrew University of Jerusalem, Israel) provided fascinating insights into venom ecology and evolution, including the dynamics of venom evolution across large time, evolutionary origin and development of venom-producing cells, coevolutionary arms races, molecular mechanisms of venom action, the genetic basis of venom resistance, and the role of environmental and ecological factors in driving the evolution of venom. Support the show

Wilson's Disease explained (Hepatolenticular Degeneration), including its pathophysiology and genetics, signs and symptoms, diagnosis (with criteria!) and treatment options. Consider subscribing on YouTube (if you found any of the info useful!): https://www.youtube.com/channel/UCRks8wB6vgz0E7buP0L_5RQ?sub_confirmation=1Patreon: https://www.patreon.com/rhesusmedicineBuy Us A Coffee!: https://www.buymeacoffee.com/rhesusmedicineTimestamps:0:00 What is Wilson's Disease0:21 Wilson's Disease Pathophysiology2:06 Wilson's Disease Symptoms3:37 Wilson's Disease Causes4:07 Wilson's Disease Diagnosis 5:46 Wilson's Disease Criteria (Leipzig Score)6:20 Wilson's Disease Treatment References:BMJ Best Practice (2024) Wilson's Disease. Available at https://bestpractice.bmj.com/topics/en-gb/427/Larry E. Johnson - MSD Manual Pro (2023) Wilson Disease. Available at https://www.msdmanuals.com/professional/nutritional-disorders/mineral-deficiency-and-toxicity/wilson-diseaseGaillard F, Deng F, Weerakkody Y, et al. (2020) Face of the giant panda sign (midbrain). Available at https://radiopaedia.org/articles/face-of-the-giant-panda-sign-midbrainWu, Fei & Wang, Jing & Pu, Chunwen & Qiao, Liang & Jiang, Chunmeng (2015) Wilson's Disease: A Comprehensive Review of the Molecular Mechanisms. Available at https://www.researchgate.net/figure/Copper-is-delivered-by-HCTR1-to-cytosol-where-it-mainly-binds-to-Atox1-Atox1-transfers_fig2_276910514Please remember this podcast and all content from Rhesus Medicine is meant for educational purposes only and should not be used as a guide to diagnose or to treat. Please consult a healthcare professional for medical advice. 

Robert T. Fremeau, Jr., Ph.D., delves into Rett syndrome, a complex neurological condition. His research with brain organoids unveils its origins and progression. Fremeau uncovers disease markers and innovative treatments, offering insight into the pursuit of breakthrough therapies. Series: "Autism Tree Project Annual Neuroscience Conference" [Health and Medicine] [Science] [Show ID: 39167]

Robert T. Fremeau, Jr., Ph.D., delves into Rett syndrome, a complex neurological condition. His research with brain organoids unveils its origins and progression. Fremeau uncovers disease markers and innovative treatments, offering insight into the pursuit of breakthrough therapies. Series: "Autism Tree Project Annual Neuroscience Conference" [Health and Medicine] [Science] [Show ID: 39167]

Robert T. Fremeau, Jr., Ph.D., delves into Rett syndrome, a complex neurological condition. His research with brain organoids unveils its origins and progression. Fremeau uncovers disease markers and innovative treatments, offering insight into the pursuit of breakthrough therapies. Series: "Autism Tree Project Annual Neuroscience Conference" [Health and Medicine] [Science] [Show ID: 39167]

Robert T. Fremeau, Jr., Ph.D., delves into Rett syndrome, a complex neurological condition. His research with brain organoids unveils its origins and progression. Fremeau uncovers disease markers and innovative treatments, offering insight into the pursuit of breakthrough therapies. Series: "Autism Tree Project Annual Neuroscience Conference" [Health and Medicine] [Science] [Show ID: 39167]

Robert T. Fremeau, Jr., Ph.D., delves into Rett syndrome, a complex neurological condition. His research with brain organoids unveils its origins and progression. Fremeau uncovers disease markers and innovative treatments, offering insight into the pursuit of breakthrough therapies. Series: "Autism Tree Project Annual Neuroscience Conference" [Health and Medicine] [Science] [Show ID: 39167]

Robert T. Fremeau, Jr., Ph.D., delves into Rett syndrome, a complex neurological condition. His research with brain organoids unveils its origins and progression. Fremeau uncovers disease markers and innovative treatments, offering insight into the pursuit of breakthrough therapies. Series: "Autism Tree Project Annual Neuroscience Conference" [Health and Medicine] [Science] [Show ID: 39167]

Robert T. Fremeau, Jr., Ph.D., delves into Rett syndrome, a complex neurological condition. His research with brain organoids unveils its origins and progression. Fremeau uncovers disease markers and innovative treatments, offering insight into the pursuit of breakthrough therapies. Series: "Autism Tree Project Annual Neuroscience Conference" [Health and Medicine] [Science] [Show ID: 39167]

What if the secret to longevity lies not only in our genes but in our lifestyle choices and our resilience? Welcome back to another engaging episode of Inflammation Nation. This time, we take a leap into the subject of aging and resilience, zooming in on how this gradual process impacts our bodies differently and at varying rates. Listen closely as we unmask the markers of resilience in your body systems and unravel the importance of maintaining balance and control amidst stress.We then venture into the fascinating realm of cellular aging, shedding light on the structural and functional abnormalities that occur in our organs due to accumulated damage. Have you ever wondered why more people are living past a century but aren't necessarily healthier in their bonus years? We dissect this paradox, highlighting differences in longevity between men and women. Our exploration goes deeper to discuss fertility, childbearing, and caregiving and their intriguing impacts on brain health, hormonal balance, and immune system competence.Lastly, in the quest to answer the question: "How can we retain resilience as we age and improve our health span?" we dig into the world of genetics, focusing on the APOE gene and unique gene mutations. We also illuminate our paths with the molecular mechanisms of longevity, including the role of telomeres, DNA repair, and the heroes of the story, the sirtuins, in ensuring we age well. Get ready for an intense, enlightening session as we dissect longevity, telomeres, and cellular aging. Let's unravel the secrets of aging well, together.https://www.instagram.com/drnoseworthyhttps://www.facebook.com/becomeautonomoushttps://www.tiktok.com/@drsnoseworthy

How would I describe my plant medicine experience? Have you ever met God in a 3 day weekend?  My experience(s) with plant medicine have been the most profound of my life. Particularly, the most beautiful experience I've had I share with you during this episode. I break down the science and the studies in PART ONE so make sure to listen if you haven't yet! It's incredibly important to understand these compounds for ourselves and not be coerced into an experience that may not be right for us. My experience was anything unlike I could have ever asked for. Into the depths of pain, then lifted into the heavens of beauty. I share the synchronicities, the miracles, and the messy in this episode PART TWO with you this week! If you're desiring a little slice of heaven in your earbuds..  Just press play!   Jen's story: https://www.inspirehealthbyjen.com/meetjen Work with Jen: https://www.inspirehealthbyjen.com/discovery-call Jen's Blog: https://www.middaypigeon.com/ INFRARED: https://www.inspirehealthbyjen.com/infrared-therapy Studies cited: Domínguez-Clavé, E., Soler, J., Elices, M., Pascual, J. C., Álvarez, E., de la Fuente Revenga, M., Friedlander, P., Feilding, A., & Riba, J. (2016). Ayahuasca: Pharmacology, neuroscience and therapeutic potential. Brain research bulletin, 126(Pt 1), 89–101. https://doi.org/10.1016/j.brainresbull.2016.03.002 Gukasyan, N., Davis, A. K., Barrett, F. S., Cosimano, M. P., Sepeda, N. D., Johnson, M. W., & Griffiths, R. R. (2022). Efficacy and safety of psilocybin-assisted treatment for major depressive disorder: Prospective 12-month follow-up. Journal of psychopharmacology (Oxford, England), 36(2), 151–158. https://doi.org/10.1177/02698811211073759 Ling, S., Ceban, F., Lui, L. M. W., Lee, Y., Teopiz, K. M., Rodrigues, N. B., Lipsitz, O., Gill, H., Subramaniapillai, M., Mansur, R. B., Lin, K., Ho, R., Rosenblat, J. D., Castle, D., & McIntyre, R. S. (2022). Molecular Mechanisms of Psilocybin and Implications for the Treatment of Depression. CNS drugs, 36(1), 17–30. https://doi.org/10.1007/s40263-021-00877-y Palhano-Fontes, F., Soares, B. L., Galvão-Coelho, N. L., Arcoverde, E., & Araujo, D. B. (2022). Ayahuasca for the Treatment of Depression. Current topics in behavioral neurosciences, 56, 113–124. https://doi.org/10.1007/7854_2021_277 Palhano-Fontes, F., Barreto, D., Onias, H., Andrade, K. C., Novaes, M. M., Pessoa, J. A., Mota-Rolim, S. A., Osório, F. L., Sanches, R., Dos Santos, R. G., Tófoli, L. F., de Oliveira Silveira, G., Yonamine, M., Riba, J., Santos, F. R., Silva-Junior, A. A., Alchieri, J. C., Galvão-Coelho, N. L., Lobão-Soares, B., Hallak, J. E. C., … Araújo, D. B. (2019). Rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression: a randomized placebo-controlled trial. Psychological medicine, 49(4), 655–663. https://doi.org/10.1017/S0033291718001356

Ever wondered about plant medicine, or what a holistic nurse practitioner might think on the topic? Is it drugs.. or is it really (plant) medicine?? Are people just hallucinating in the forest or do the plants induce neurogenesis along with new neural pathways? Today I'm going to share with you the place where science and Spirit meet. I'm not a traditional shaman nor am I giving medical advice. I am sharing with you two things: My evidenced based research on the clinical trials that have taken place using plant medicine for mental health and quality of life My own personal experience with plant medicine during my healing journey If you're curious about this topic and just want to peek your nose in to get a tiny whiff, then this episode is for you! This episode is for the planty believers, naysayers, and anywhere you might find yourself in between. Now let's dive in :) Show notes: Jen's story: https://www.inspirehealthbyjen.com/meetjen Work with Jen: https://www.inspirehealthbyjen.com/discovery-call Jen's Blog: https://www.middaypigeon.com/ INFRARED: https://www.inspirehealthbyjen.com/infrared-therapy   Studies cited: Domínguez-Clavé, E., Soler, J., Elices, M., Pascual, J. C., Álvarez, E., de la Fuente Revenga, M., Friedlander, P., Feilding, A., & Riba, J. (2016). Ayahuasca: Pharmacology, neuroscience and therapeutic potential. Brain research bulletin, 126(Pt 1), 89–101. https://doi.org/10.1016/j.brainresbull.2016.03.002   Gukasyan, N., Davis, A. K., Barrett, F. S., Cosimano, M. P., Sepeda, N. D., Johnson, M. W., & Griffiths, R. R. (2022). Efficacy and safety of psilocybin-assisted treatment for major depressive disorder: Prospective 12-month follow-up. Journal of psychopharmacology (Oxford, England), 36(2), 151–158. https://doi.org/10.1177/02698811211073759 Ling, S., Ceban, F., Lui, L. M. W., Lee, Y., Teopiz, K. M., Rodrigues, N. B., Lipsitz, O., Gill, H., Subramaniapillai, M., Mansur, R. B., Lin, K., Ho, R., Rosenblat, J. D., Castle, D., & McIntyre, R. S. (2022). Molecular Mechanisms of Psilocybin and Implications for the Treatment of Depression. CNS drugs, 36(1), 17–30. https://doi.org/10.1007/s40263-021-00877-y   Palhano-Fontes, F., Soares, B. L., Galvão-Coelho, N. L., Arcoverde, E., & Araujo, D. B. (2022). Ayahuasca for the Treatment of Depression. Current topics in behavioral neurosciences, 56, 113–124. https://doi.org/10.1007/7854_2021_277   Palhano-Fontes, F., Barreto, D., Onias, H., Andrade, K. C., Novaes, M. M., Pessoa, J. A., Mota-Rolim, S. A., Osório, F. L., Sanches, R., Dos Santos, R. G., Tófoli, L. F., de Oliveira Silveira, G., Yonamine, M., Riba, J., Santos, F. R., Silva-Junior, A. A., Alchieri, J. C., Galvão-Coelho, N. L., Lobão-Soares, B., Hallak, J. E. C., … Araújo, D. B. (2019). Rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression: a randomized placebo-controlled trial. Psychological medicine, 49(4), 655–663. https://doi.org/10.1017/S0033291718001356  

"The genes sort of load the crossbow and the environment pulls the trigger," says Sara Pugh.   In the latest Quantum Biology Collective podcast, Meredith Oke teams up with returning guest, Sara Pugh. Sara has a degree in Biochemistry Genetics, a PhD in Molecular Mechanisms, as well as training in Functional Neurology, Pilates, and Hypnosis. Sara and Meredith dissect the interplay between our genetics and our environment and provide a great orientation for QBC listeners who are newer to the topic.   Dispelling the notion that genes alone shape our health, Sara introduces the environment as a crucial activator, determining gene expression. Zeroing in on light, she reveals how our skin and eyes capture different light wavelengths, influencing our genes and the vital mitochondria.   Sara underscores the ripple effects of light on our health, showing how misaligned exposure can contribute to conditions like obesity or mood disorders. Advocating for alignment with natural rhythms, she emphasizes morning sun exposure and genuine nighttime darkness, and natural unprocessed food.   Sara offers actionable insights, suggesting ways to mitigate modern lifestyle pitfalls, from grounding oneself to harnessing natural light indoors. There is an illustrative story in this episode which involves a truck driver whose outdoor meals ignited a significant health turnaround!   Quotes: "The important thing to understand is that the genes sort of load the crossbow and the environment pulls the trigger." (02:04 | Sara Pugh)  "Our bodies go into chaos and they don't know what to do when we give an incorrect signal, like bright light when it's supposed to be dark or darkness when it's supposed to be day." (11:37 | Sara Pugh) "So in the old paradigm, their genetics determine everything. And then the old paradigm, like an ice cream cone is an ice cream cone. It has this many calories and this many grams of fat and that's that. But in the quantum paradigm, walking to the ice cream parlor and getting an ice cream and walking outside in the sunshine while you eat it has a different effect than eating an ice cream cone at home, watching television when it's dark outside and you're being bombarded by even though the ice cream may have the same calories and the same fat, the effect on your body is totally different depending on the environment and the actions that you're taking while you're eating it." (31:20 | Meredith Oke) "We want to increase the signals that create coherence in the body. Those signals tend to come from nature and natural food, things that nature produced." (43:28 | Sara Pugh)  "The light and other frequencies give the signal to our bodies to be in coherence and that when our bodies are in coherence, we feel better." (45:44 | Sara Pugh)   Links Connect with Sara Pugh: Sara's Newsletter Opt In: https://get.busysuperhuman.com/newsletter1 Instagram, Tik Tok and YouTube: @busysuperhuman    To find a practitioner who understand the health principles of quantum biology: www.quantumbiologycollective.org  To become a QBC member and get invites to live deep dives & access to our video library: www.quantumhealthtv.com  To take our 8 week practitioner certification in the science of quantum biology so that you can add it to your existing area of expertise: www.appliedquantumbiology.com    Follow on Twitter, Instagram & Facebook: @quantumhealthtv    Podcast production and show notes provided by HiveCast.fm

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.28.550979v1?rss=1 Authors: Mishra, S., Manohar, V., Chandel, S., Manoj, T., Bhattacharya, S., Hegde, N., Nath, V. R., Hegde, N., Wendling, C., Di Mattia, T., Martinet, A., Chimata, P., Alpy, F., PADINJAT, R. Abstract: Lipid transfer proteins mediate the transfer of lipids between organelle membranes in eukaryotes and loss of function in these has been linked to neurodegenerative disorders. However, the mechanism by which loss of lipid transfer protein function leads to neurodegeneration is not understood. In Drosophila photoreceptors, depletion of Retinal Degeneration B (RDGB), a phosphatidylinositol transfer protein localized to endoplasmic reticulum-plasma membrane contact sites leads to defective phototransduction and retinal degeneration but the mechanism by which RDGB function is regulated and the process by which loss of this activity leads to retinal degeneration is not understood. RDGB is localized to membrane contact sites (MCS) and this depends in the interaction of its FFAT motif with the ER integral protein VAP. To identify regulators of RDGB function in vivo, we depleted more than 300 VAP interacting proteins and identified a set of 52 suppressors of rdgB. The molecular identity of these suppressors indicates a role for novel lipids in regulating RDGB function and for transcriptional and ubiquitination processes in mediating retinal degeneration in rdgB. The human homologs of several of these molecules have been implicated in neurodevelopmental diseases underscoring the importance of VAP mediated processes in these disorders. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Gaia Navarino shares her work on disorder-causing genetic mutations at the system, cellular and molecular level. With a focus on autism spectrum disorder, she explains techniques used to identify common pathophysiological mechanisms in ASD and how that could provide a framework for the development of effective pharmacological therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38325]

Gaia Navarino shares her work on disorder-causing genetic mutations at the system, cellular and molecular level. With a focus on autism spectrum disorder, she explains techniques used to identify common pathophysiological mechanisms in ASD and how that could provide a framework for the development of effective pharmacological therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38325]

Gaia Navarino shares her work on disorder-causing genetic mutations at the system, cellular and molecular level. With a focus on autism spectrum disorder, she explains techniques used to identify common pathophysiological mechanisms in ASD and how that could provide a framework for the development of effective pharmacological therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38325]

Gaia Navarino shares her work on disorder-causing genetic mutations at the system, cellular and molecular level. With a focus on autism spectrum disorder, she explains techniques used to identify common pathophysiological mechanisms in ASD and how that could provide a framework for the development of effective pharmacological therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38325]

Gaia Navarino shares her work on disorder-causing genetic mutations at the system, cellular and molecular level. With a focus on autism spectrum disorder, she explains techniques used to identify common pathophysiological mechanisms in ASD and how that could provide a framework for the development of effective pharmacological therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38325]

Gaia Navarino shares her work on disorder-causing genetic mutations at the system, cellular and molecular level. With a focus on autism spectrum disorder, she explains techniques used to identify common pathophysiological mechanisms in ASD and how that could provide a framework for the development of effective pharmacological therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38325]

Gaia Navarino shares her work on disorder-causing genetic mutations at the system, cellular and molecular level. With a focus on autism spectrum disorder, she explains techniques used to identify common pathophysiological mechanisms in ASD and how that could provide a framework for the development of effective pharmacological therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38325]

Gaia Navarino shares her work on disorder-causing genetic mutations at the system, cellular and molecular level. With a focus on autism spectrum disorder, she explains techniques used to identify common pathophysiological mechanisms in ASD and how that could provide a framework for the development of effective pharmacological therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38325]

Are your mental health pills making you feel bad? In this episode of The Evolving Wellness podcast, I am joined by Dr. Rachel Brown and Dr. Sara Pugh to discuss the impact of mental health medications on the body. We live in a world where these types of medications, such as SSRIs, are over-prescribed, and thus too many people experience negative side effects. Oftentimes, these pills are prescribed before a patient is recommended to fix basic pillars of health, such as diet, sleep, and exercise. We explore a few things one can do to improve their mental health naturally and easily before one resort to prescription drugs. We also chat about the dangers of over-supplementing melatonin. When we ingest too much of it, these supplements don't act as supplements anymore but as contraceptives as they start to repress our bodies' natural ability to create melatonin itself. This can cause a lot of damage to our overall health.  Dr. Sara Pugh has a degree in Biochemistry Genetics and a Welcome Trust Ph.D. in Molecular Mechanisms. She studied protein folding, which plays a role in Alzheimer's and Parkinson's disease, antioxidants, and fluorescence. She worked as a postdoctoral researcher on heart muscle cells, cholesterol, and statins. She is published in various peer-reviewed journals. Dr. Rachel Brown works as an NHS Consultant Psychiatrist in Scotland. She qualified in medicine from the University of Edinburgh in 2003 and has worked in psychiatry since 2004. She has a Master's degree in Medical Laws and Ethics from the University of Edinburgh, in addition to being a certified Functional Medicine Practitioner. What we discuss: 00:38: About Dr. Rachel 02:57: Is nutrition important for your mental health? 03:42: About Dr. Sara 06:06: How important is pattern recognition in biology? 07:33: What is the dark history of medications? 10:45: Why is Dr. Rachel not a fan of SSRI's? 14:16: How important is the placebo effect in these types of drugs? 15:59: How do SSRI's affect sexual dysfunction? 17:59: Do Dr. Sara and Dr. Rachel recommend micro gene tests? 27:15: Why do people gain weight? 32:59: What is better than medication for your mental health? 35:45: How open are people to changing their diets? 37:43: How can being in darkness heal mania? 44:20: What about the craze of supplementing melatonin?  49:50: What are the benefits of topical peptides? 50:57: How does Dr. Sarah wash her hair? 54:58: What is Dr. Rachel's hair routine? 57:11: Why is our hair going grey a lot faster? 1:01:01: How easy is it to introduce structured water into your diet? 1:02:44: How can you find a balance between diets? 1:06:10: Does Dr. Rachel deviate from the carnivore diet? 1:08:01: Why men going on a carnivore diet tend to do it wrong 1:14:06: What is the problem with all the supplements people take? 1:18:42: Can women benefit from HRT? 01:21:50: Where can we learn more about Dr. Sara and Dr. Rachel? To learn more about Dr. Sarah and Dr. Rachel: Website: https://sarapughleeds.co.uk/ and https://foodforthoughtpsychiatrist.com/ Instagram: https://www.instagram.com/busy_superhuman/ and https://www.instagram.com/carnivoreshrink/?hl=en Thank you to our sponsors: This episode is sponsored by Optimal Carnivore - Use code CarnivoreY to save 10% - optimalcarnivore.com/sarahThis episode is sponsored by Vivarays - Use code YOGI to save 15% https://vivarays.com/carnivoreyogi This episode is sponsored by Upgraded Formulas - Use code YOGI12 or YOGI to save on anything from Upgraded Formulas - https://www.upgradedformulas.com/?rfsn=4637317.2071db5&utm_source=refersion&utm_medium=affiliate&utm_campaign=4637317.2071db5 Want more from me? FREE GUIDES: Free guide on how to use blue blockers - https://sarah-kleiner.mykajabi.com/pl/2147647734 Free guide to “Building your perfect quantum day” - https://www.sarahkleinerwellness.com/pl/2147664711 My courses: https://sarah-kleiner.mykajabi.com/store

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.24.529964v1?rss=1 Authors: Marchetto, F., Santaeufemia, S., Lebiedzinska-Arciszewska, M., Sliwinska, M. A., Pich, M., Kurek, E., Naziebło, A., Strawski, M., Solymosi, D., Szklarczyk, M., Bulska, E., Szymanski, J., Wierzbicka, M., Allahverdiyeva, Y., Wieckowski, M. R., Kargul, J. M. Abstract: The order of Cyanidiales comprise seven acido-thermophilic red microalgal species thriving in hot springs of volcanic origin characterized by extremely low pH, moderately high temperatures and the presence of elevated concentrations of sulphites and heavy metals that are prohibitive for most other organisms. Little is known about the molecular mechanisms of Cyanidiales long-term adaptation to such hostile environments, in particular to heavy metals, yet elucidation of these processes is important for understanding the evolution of the metabolic pathways underlying heavy metal detoxification for developing rational strategies for heavy metal bioremediation. Here, we investigated the long-term adaptive responses of Cyanidioschyzon merolae cells, a member of Cyanidiales, to extremely high nickel concentrations. Through complementary approaches based on physiological, microscopic and elemental analyses we dissect several molecular mechanisms underlying the long-term adaptation of this model extremophilic microalga to high Ni exposure. These include: (i) extrusion of Ni from the cells and lack of significant Ni accumulation inside the cells; (ii) maintenance of efficient photoprotective responses including non-photochemical quenching and state transitions; (iii) dynamic remodelling of the chloroplast ultrastructure such as formation of metabolically active prolamellar bodies and plastoglobuli together with loosening of the thylakoid membranes; (iv) activation of ROS amelioration metabolic pathways; and (v) preservation of the efficient respiratory chain functionality. All the dynamically regulated processes identified in this study underlie the remarkable adaptability of C. merolae to extremely high Ni levels that exceed by several orders of magnitude the levels of this heavy metal found in the natural environment of this extremophile. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Commentary by Dr. Fadi Salloum

1. The (evil?) architect of The Great Reset - Sorelle Amore Finance (10:46) *Who is Klaus Schwab, really? I'll be trying to bring a more balanced perspective to the answer to that question. Because when it comes to the leader of the WEF, it seems like most of the information that's out there is pushing a very one-sided view. 2. United Nations announces Klaus Schwab of the World Economic Forum and UN General Secretary Antonio Guterres have signed an agreement to ‘accelerate' Agenda 2030 (0:30) 3. World Economic Forum | Strategic Intelligence 4. If I Were the Devil: Paul Harvey (2:47) * Paul Harvey Aurandt was an American radio broadcaster for ABC News Radio. He broadcast News and Comment on mornings and mid-days on weekdays and at noon on Saturdays and also his famous The Rest of the Story segments. From 1951 to 2008, his programs reached as many as 24 million people per week.  5. Gun Control and The Vaule Of Life (8:09)   Vitamin B6 Supplements In High Doses Can Calm Anxiety, Depression   University of Reading (UK), July 18, 2022 Taking high-dose vitamin B6 supplements may help to reduce feelings of anxiety and depression, a new study reveals. Researchers from the University of Reading in England report that young adults taking a dose 50 times the recommended daily dose reported feeling less anxious and depressed after a month. Vitamin B6 increases the body's production of GABA (Gamma-Aminobutyric Acid), a chemical that blocks impulses between nerve cells in the brain. Vitamin B6 is found naturally in a variety of foods, including salmon, tuna, chickpeas, and bananas.  Vitamin B6 helps the body produce a specific chemical messenger that inhibits impulses in the brain, and this study links this calming effect with reduced anxiety among the participants.” The study provides evidence lacking in previous studies as to what exactly drives the stress-reducing effects of marmite and multivitamins. More than 300 participants took either a placebo or Vitamin B6 or B12 supplements at 50 times the recommended amount – around 70mg. Each participant took one tablet a day with food. Vitamin B12 had little effect compared to the placebo, but B6 showed a statistically reliable difference. The team also detected subtle but harmless changes in visual performance, consistent with controlled levels of brain activity. Health officials in the United Kingdom recommend that people do not take too high a dose – more than 200mg a day – as it can lead to a loss of feeling in the arms and legs. In a few cases, this has become permanent in people who have taken very large doses for several months.   “Many foods, including tuna, chickpeas and many fruits and vegetables, contain Vitamin B6. However, the high doses used in this trial suggest that supplements would be necessary to have a positive effect on mood,” Dr. Field continues. “It is important to acknowledge that this research is at an early stage and the effect of Vitamin B6 on anxiety in our study was quite small compared to what you would expect from medication. However, nutrition-based interventions produce far fewer unpleasant side effects than drugs, and so in the future people might prefer them as an intervention.   Study Ranks Healthiest ‘Powerhouse' Vegetables, Which is #1?  William Paterson University, July 14   Research from William Paterson University attempted to rank fruits and vegetables according to the amount of nutrition within. In all, they list 41 “powerhouse” vegetables and fruits, scoring them according to the presence of 17 nutrients. The produce was scored by the presence of: fiber, potassium, protein, calcium, folate, vitamin D, vitamin A, vitamin B12, and more.   To make the study's “powerhouse” list, the researchers calculated each fruit or vegetable's “nutrient density” score based on the percentage of your daily need for each nutrient the food provides. (The study assumed a 2,000 calorie per day diet and 100 grams of each food.) The scores were capped to ensure that a fruit or vegetable that provides a huge amount of just a single nutrient wouldn't receive a disproportionately high overall score.” So, which earned the top spot? Super easy-to-grow watercress. Watercress scored an even 100, with Chinese cabbage closest behind with a score of 91.99. In third place was chard (89.27), followed by beet greens (87.08), spinach (86.43), and chicory (73.36).  Fruits scored lower, with red pepper at the top (41.26), followed by pumpkin (32.23), tomatoes (20.37), and lemons (18.72). Many of these are surprising considering they aren't the “superfruits” we are accustomed to hearing about. But, that's largely because of the nutrients measured in this study. Fruits like blueberries, that are considered healthiest by many, earn that spot because of their antioxidant levels. This study didn't capture the concentration of antioxidants, however.       Can listening to the Beatles improve your memory? New research says music just might stir the brain Northeastern University, July 19, 2022 When Paul McCartney wrote "Get Back," he never would have predicted how useful or relevant the song would become for music therapists. The song's refrain—"Get back to where you once belonged"—might as well be a therapist encouraging a dementia patient to recall a distant memory. In new research, Psyche Loui, an associate professor of music, is attempting to do exactly that. Published in Scientific Reports, Loui found that for older adults who listened to some of their favorite music, including The Beatles, connectivity in the brain increased. Specifically, Loui—and her multi-disciplinary team of music therapists, neurologists and geriatric psychiatrists—discovered that music bridged the gap between the brain's auditory system and reward system, the area that governs motivation. The researchers had a group of older adults between the ages of 54 and 89 from the Boston area listen to a playlist for an hour every day for eight weeks and journal about their response to the music afterward. Loui and the team would scan the participants' brains before and after listening in order to measure their neurological response. Playlists were highly personalized and featured a combination of the participants' self-selected songs, which ranged from The Beatles to Bruce Springsteen, and a preselected mix of classical pieces, pop and rock songs and new compositions.The most important lesson that we learned from the music therapist was that there is no one-size-fits-all for what kind of music works best," Loui said. What the researchers found was striking: Music was essentially creating an auditory channel directly to the medial prefrontal cortex, the brain's reward center. Notably, the medial prefrontal cortex "is one of the areas to lose its activity and functional connectivity in aging adults, especially in folks with dementia," Loui said. Music that was both familiar and well-liked tended to activate the auditory and reward areas more. However, the music that participants selected themselves provided an even stronger connection between these two areas of the brain.   DHA omega-3 linked to ‘significantly improved periodontal outcomes': Harvard data Harvard University, July 14 ,2022 Scientists from Harvard report that supplementation with DHA (docosahexaenoic acid) omega-3 may improve periodontal outcomes in people with periodontitis. Periodontitis is a serious gum infection that destroys the soft tissue and bone supporting the teeth. It is reportedly the second most common disease worldwide, with 30–50% of the US population suffering from it. Data published in the Journal of Dental Research indicated that DHA supplementation was associated with a decreased the average depth of the pockets between the teeth and the gums, and the gingival index, which is used to assess the extent of gum disease. In addition, inflammatory biomarkers in the gum tissue were significantly reduced. Participants were randomly assigned to receive either 2,000 mg per day of DHA or placebo (soy/corn oil) for three months. All of the participants also received 81 mg per day of aspirin. Results showed DHA levels in red blood cell membranes increased between 3.6% to 6.2%, whereas no such increases were observed in the placebo group. In addition to the improvements in pocket depth and gingival index, the researchers reported that levels of the inflammatory biomarkers C-reactive protein (CRP) and interleukin-1 beta (IL-1beta) decreased significantly in the DHA group.      This “Holy Herb' Shows Promise in Treating Alzheimer's Disease Yerba santa may also treat brain swelling in dementia patients Salk Institute, July 14, 2022 A shrub known as Yerba santa, dubbed “holy herb” in Spanish, appears to show promise in treating Alzheimer's disease, researchers say. It has the potential to reduce brain swelling in people with dementia.  Native to California, Yerba santa has long been used as a treatment for fevers, headaches, and other common ailments. But researchers at Salk's Cellular Neurobiology Laboratory believe it could be used to treat much more serious health problems. In fact, millions of dementia patients stand to benefit from the natural treatment, they claim. A molecule in the shrub called sterubin – the plant's most active component – could be the key to transforming millions of lives. The team found that sterubin had a significant anti-inflammatory effect on brain cells called microglia, which are involved in the development of Alzheimer's disease, among other ailments. The researchers further found that sterubin effectively removes iron. This is an important discovery, as iron contributes to nerve cell damage in the aging brain and neurodegenerative diseases. Sterubin was found to effectively reduce numerous causes of cell death in the nerve cells.   An inflammatory diet correlates with colorectal cancer risk The risk of developing colorectal cancer for individuals that follow a pro-inflammatory diet is two times higher than usual Bellvitge Biomedical Research Institute (Spain), July 15, 2022  Researchers from the Molecular Mechanisms and Experimental Therapy in Oncology program (Oncobell) of the Bellvitge Biomedical Research Institute (IDIBELL) and the Catalan Institute of Oncology (ICO) published in Nutrients the results of a multicenter study that unveils a correlation between inflammatory and antioxidant diets and the risk of developing colorectal and breast cancer.  "We have observed an association between the risk of developing colorectal cancer and the inflammatory potential of the diet. That is, the participants who followed an inflammatory diet had almost twice the risk of developing colorectal cancer, which is the 4th most frequent cancer worldwide", explains Dr. Mireia Obón. An inflammatory diet is usually characterized by the consumption of refined carbohydrates, red and processed meat, and saturated or trans fats. In an antioxidant diet, the consumption of vegetables, legumes, fruits and nuts predominates. "In this study we have focused on the role of diet, and specifically on its inflammatory and antioxidant capacity, as there is evidence that both chronic inflammation and oxidative stress influence the development of these two types of cancer", says Dr. Víctor Moreno. "Following a pro-inflammatory and pro-oxidant diet is a very important risk factor for colon cancer.  We should reorient our eating habits towards a Mediterranean diet, rich in fruits and vegetables, nuts, whole grains and healthy oils, such as olive oil and move away from a more pro-inflammatory diet", she argues.     OCCUPY PEACE & FREEDOM RALLY INFO Saturday, July 23 -- 2:00 pm Kingston, NY (at the historical 4 corners -- Crown and John Streets) Speakers: Gerald Celente Judge Andrew Napolitano Gary Null Scott Ritter Phil Giraldi (former CIA official) Live music, food and drink

Polycystic ovary syndrome (PCOS) is a common condition impacting roughly one in four women of reproductive age. , In this show we discuss natural ways to reverse the underlying factors driving PCOS.  Save 15% OFF on Berberine HCl and Myo-Inositol containing Sleep Formulations from MYOXCIENCE Save with code podcast at checkout  Links to Studies, Images and the Video Version: https://bit.ly/3nMt9QJ Time Stamps 00:04 PCOS (polycystic ovarian syndrome) is about 1 in 5 of women of childbearing age. 00:26 The root cause of PCOS is poor metabolic health. 01:54 Ovaries hyper secrete androgens that are linked with challenges within the ovaries and the formation of water-forming cysts. 02:39 Hormonal birth control is frequently prescribed to increase sex hormone binding globulin and neutralize the elevated androgens. 04:04 Some cytochrome P450 enzymes are involved in the formation of steroid-like hormones, like testosterone. 05:04 Insulin and IGF-1 increase the activity of a cytochrome P450 enzyme called CYP17A1, which then increases testosterone, dihydrotestosterone, and DHEA within the ovaries. 06:36 Excessive levels of androgens cause hair loss, infertility, lack of ovulation, and cause the formation of water forming cysts within the ovaries. 08:24 Autoimmunity often co-occurs with PCOS. 08:44 Deliberate cold exposure helps metabolic health by stimulating brown and beige fat cells. 09:54 Metabolic health increases the activity of enzymes that create hormones. It does the inverse in men and women. 10:04 Men's poor metabolic health drives the formation of extra estrogen. 10:14 Women's poor metabolic health drives the formation of extra testosterone. 12:44 97% of obese women have PCOS. 65% of non-obese women have PCOS. 13:14 Fat cells secrete hormones, called adipocytokines. One of these is leptin. 13:54 Leptin decreases activity of T-regulatory cells that help to prevent autoimmunity. 16:04 Belly fat cells convert androgens into estrogens. This is impacted by insulin. 18:14 Nutrition and exercise are fundamental ways to address poor metabolic health. 18:24 A ketogenic or low carb diet is helpful because it manages blood sugar and insulin, and ketones have immune signaling properties. 19:24 Intermittent fasting can support glycemic variability and improve insulin sensitivity. 19:46 Time restricted feeding with a 16 or 18 hour fast is also helpful for longevity, burning fat, and supporting metabolic health. 20:14 Poor sleep exacerbates insulin resistance. Tape your mouth shut when you sleep. 21:24 Resistance training decreases androgens in women with PCOS. All exercise supports underlying metabolic dysfunction. 22:24 Magnesium is helpful for supporting insulin sensitivity. 23:15 Myo-inositol and inositol makes ovaries more sensitive to insulin, preventing the increase in androgens. 24:04 Vitamin D is involved in blood sugar regulation, immune health, and sleep quality. 24:19 Gut health is important to metabolic health. Eat real food and ferments. 24:54 Berberine hydrochloride, 500 mg 1 to 3 times per day, is a natural Metformin. Studies Mentioned Witchel, S. F., & Plant, T. M. (2020). Intertwined reproductive endocrinology: Puberty and polycystic ovary syndrome. Current Opinion in Endocrine and Metabolic Research, 14, 127–136. http://doi.org/10.1016/j.coemr.2020.07.004 Stefanaki, C., Bacopoulou, F., Kandaraki, E., Boschiero, D., & Diamandi-Kandarakis, E. (2019). Lean Women on Metformin and Oral Contraceptives for Polycystic Ovary Syndrome Demonstrate a Dehydrated Osteosarcopenic Phenotype: A Pilot Study. Nutrients, 11(9), 2055. http://doi.org/10.3390/nu11092055 Moghetti, P., & Tosi, F. (2020). Insulin resistance and PCOS: chicken or egg? Journal of Endocrinological Investigation, 44(2), 233–244. http://doi.org/10.1007/s40618-020-01351-0 Scarfò, G., Daniele, S., Fusi, J., Gesi, M., Martini, C., Franzoni, F., et al. (2022). Metabolic and Molecular Mechanisms of Diet and Physical Exercise in the Management of Polycystic Ovarian Syndrome. Biomedicines, 10(6), 1305. http://doi.org/10.3390/biomedicines10061305 Witchel, S. F., & Plant, T. M. (2020). Intertwined reproductive endocrinology: Puberty and polycystic ovary syndrome. Current Opinion in Endocrine and Metabolic Research, 14, 127–136. http://doi.org/10.1016/j.coemr.2020.07.004 Optimal management of polycystic ovary syndrome in adolescence. (2015). Optimal management of polycystic ovary syndrome in adolescence, 1–8. http://doi.org/10.1136/archdischild-2014-306471&domain=pdf&date_stamp=2015-06-22

In this episode, Antonia and Andrew discuss a selection of articles from the May 18, 2022 issue of JBJS, along with an added dose of entertainment and pop culture. Listen at the gym, on your commute, or whenever your case is on hold! Articles Discussed: Health-Care Utilization and Expenditures Associated with Long-Term Treatment After Combat and Non-Combat-Related Orthopaedic Trauma, by Hering et al. Bipolar Hemiarthroplasty Does Not Result in a Higher Risk of Revision Compared with Total Hip Arthroplasty for Displaced Femoral Neck Fractures. An Instrumental Variable Analysis of 36,118 Procedures from the Australian Orthopaedic Association National Joint Replacement Registry, by Farey et al. Antibiotic Prophylaxis with Cefazolin Is Associated with Lower Shoulder Periprosthetic Joint Infection Rates Than Non-Cefazolin Alternatives, by Marigi et al. Outcomes and Survivorship at a Median of 8.9 Years Following Hip Arthroscopy in Adolescents with Femoroacetabular Impingement. A Matched Comparative Study with Adults, by Fukase et al. Intermediate to Long-Term Outcomes and Causes of Aseptic Failure of an At-Risk Femoral Stem, by Gazendam et al. Long-Term Survival of HINTEGRA Total Ankle Replacement in 683 Patients. A Concise 20-Year Follow-up of a Previous Report, by Kvarda et al. A Novel Fluoroscopic View for Improved Assessment of the Safety of the Posterosuperior Screw in Femoral Neck Fracture Fixation, by Terhune et al. Spontaneous Facet Joint Osteoarthritis in NFAT1-Mutant Mice. Age-Dependent Histopathologic Characteristics and Molecular Mechanisms, by Wang et al. Association of a Wider Medial Gap (Medial Laxity) in Flexion with Self-Reported Knee Instability After Medial-Pivot Total Knee Arthropla

Learn what the research says about light interactions with the cells of the brain with Dr. Rountree and Kristi! They discuss the complex web of cellular functions in the brain, what neurodegeneration is, how laser therapy interacts with the brain, and how it can benefit patients with neurodegenerative disorders. Follow along to learn more about how laser therapy could be used to slow the progression of disorders such as Alzheimer's, Parkinson's, ALS, Dementia, and more. We have begun live-streaming this podcast. Watch this episode on Facebook right here, and see the next episode LIVE in two weeks!Study mentioned in this episode:The Molecular Mechanisms of Action of Photobiomodulation Against Neurodegenerative Diseases: A Systematic ReviewVisit the LTI website for more information and to find a laser therapy provider near you.  Are you a healthcare provider?Laser Therapy Institute Podcast  YouTube ChannelHealing at the Speed of Light

Huberman Lab Podcast Notes Key Takeaways Regular use of sauna and other heat exposure can reduce mortality by cardiovascular events, stroke, and all-cause mortalityEffects of deliberate heat mimic cardiovascular exerciseGeneral guideline to start heat stimulus: temperature must be between 176F-212F for 5-20 minutes, 2-7 times per week – later in the day is better to activate cooling mechanisms and assist with sleepFind what works for you: choose either higher heat intensity and shorter bouts, or lower heat intensity and longer bouts – but always between 176F-212FMake sure you're replacing the water you lose in the sauna – drink at least 16 ounces of water for every 10 minutes of sauna useIf growth hormone increase is your main goal for sauna use, limit to 1x/week or 1x/10 days – and enter fasted or without food in the 2-3 hours prior for maximum benefitsProper application of local heat may actually change the identity of fat cells at that location and encourage the conversion of white fat to beige fatRead the full notes @ podcastnotes.orgI describe the mechanisms by which deliberate heat exposure impacts body temperature, metabolism, heart health, hormone production, exercise recovery, cognition, mood, and longevity. I detail specific protocols for deliberate heat exposure, including exposure times, temperature ranges to consider, time of day, and delivery mechanisms (sauna vs. hot bath vs. open air heat, etc.) in order to achieve different specific outcomes, including dramatic growth hormone releases, or reduction in cortisol levels. I also discuss the ability of locally applied heat to heal or otherwise improve various bodily tissues and new data on how local application of heat may induce the conversion of metabolically sluggish white fat to metabolically robust beige fat. Thank you to our sponsors LMNT: https://drinklmnt.com/huberman InsideTracker: https://insidetracker.com/huberman ROKA - https://www.roka.com - code "huberman" See Andrew Huberman Live: The Brain Body Contract Tuesday, May 17th: Seattle, WA Wednesday, May 18th: Portland, OR https://hubermanlab.com/tour Our Patreon page https://www.patreon.com/andrewhuberman Supplements from Momentous I am pleased to announce that the Huberman Lab Podcast is now partnered with Momentous. Momentous supplements are of the very highest quality; each is third-party tested for purity and accuracy of dosage. To learn more about the Huberman Lab Podcast-Momentous partnership, the supplements I that take, and stay up-to-date with future product announcements, visit: https://www.livemomentous.com/huberman. For the full show notes, visit hubermanlab.com. Timestamps (00:00:00) Heat & Health (00:03:37) Momentous Supplements (00:04:52) The Brain-Body Contract (00:05:46) LMNT, InsideTracker, ROKA (00:09:31) Body Shell Temperature vs. Body Core Temperature (00:13:28) Thermal Regulation, Hyperthermia (00:17:36) Heat Removal Circuits, Pre-Optic Hypothalamus (POA) (00:26:30) Protocols & Benefits of Deliberate Heat Exposure (00:33:37) Tools & Conditions for Deliberate Heat Exposure (00:38:47) Deliberate Heat Exposure, Cortisol & Cardiovascular Health (00:44:50) Heat Shock Proteins (HSPs), Molecular Mechanisms of Heat Regulation (00:47:56) Longevity & Heat Exposure, FOXO3 (00:52:30) Deliberate Cold & Heat Exposure & Metabolism (00:54:48) Deliberate Heat Exposure & Growth Hormone (01:04:32) Parameters for Heat & Cold Exposure (01:08:26) Circadian Rhythm & Body Temperature, Cold & Heat Exposure (01:12:00) Heat Exposure & Growth Hormone (01:16:20) Tool: Hydration & Sauna (01:17:10) Heat, Endorphins & Dynorphins, Mood (01:28:44) Tool: Glabrous Skin To Heat or Cool (01:35:33) Local Hyperthermia, Converting White Fat to Beige Fat, Metabolism (01:47:00) Hormesis/Mitohormesis & Heat/Cold Exposure (01:49:11) Benefits of Heat Exposure (01:51:10) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, Instagram, Twitter, Neural Network Newsletter Title Card Photo Credit: Mike Blabac Disclaimer

I describe the mechanisms by which deliberate heat exposure impacts body temperature, metabolism, heart health, hormone production, exercise recovery, cognition, mood, and longevity. I detail specific protocols for deliberate heat exposure, including exposure times, temperature ranges to consider, time of day, and delivery mechanisms (sauna vs. hot bath vs. open air heat, etc.) in order to achieve different specific outcomes, including dramatic growth hormone releases, or reduction in cortisol levels. I also discuss the ability of locally applied heat to heal or otherwise improve various bodily tissues and new data on how local application of heat may induce the conversion of metabolically sluggish white fat to metabolically robust beige fat. Thank you to our sponsors LMNT: https://drinklmnt.com/huberman InsideTracker: https://insidetracker.com/huberman ROKA - https://www.roka.com - code "huberman" See Andrew Huberman Live: The Brain Body Contract Tuesday, May 17th: Seattle, WA Wednesday, May 18th: Portland, OR https://hubermanlab.com/tour Our Patreon page https://www.patreon.com/andrewhuberman Supplements from Momentous I am pleased to announce that the Huberman Lab Podcast is now partnered with Momentous. Momentous supplements are of the very highest quality; each is third-party tested for purity and accuracy of dosage. To learn more about the Huberman Lab Podcast-Momentous partnership, the supplements I that take, and stay up-to-date with future product announcements, visit: https://www.livemomentous.com/huberman. For the full show notes, visit hubermanlab.com. Timestamps (00:00:00) Heat & Health (00:03:37) Momentous Supplements (00:04:52) The Brain-Body Contract (00:05:46) LMNT, InsideTracker, ROKA (00:09:31) Body Shell Temperature vs. Body Core Temperature (00:13:28) Thermal Regulation, Hyperthermia (00:17:36) Heat Removal Circuits, Pre-Optic Hypothalamus (POA) (00:26:30) Protocols & Benefits of Deliberate Heat Exposure (00:33:37) Tools & Conditions for Deliberate Heat Exposure (00:38:47) Deliberate Heat Exposure, Cortisol & Cardiovascular Health (00:44:50) Heat Shock Proteins (HSPs), Molecular Mechanisms of Heat Regulation (00:47:56) Longevity & Heat Exposure, FOXO3 (00:52:30) Deliberate Cold & Heat Exposure & Metabolism (00:54:48) Deliberate Heat Exposure & Growth Hormone (01:04:32) Parameters for Heat & Cold Exposure (01:08:26) Circadian Rhythm & Body Temperature, Cold & Heat Exposure (01:12:00) Heat Exposure & Growth Hormone (01:16:20) Tool: Hydration & Sauna (01:17:10) Heat, Endorphins & Dynorphins, Mood (01:28:44) Tool: Glabrous Skin To Heat or Cool (01:35:33) Local Hyperthermia, Converting White Fat to Beige Fat, Metabolism (01:47:00) Hormesis/Mitohormesis & Heat/Cold Exposure (01:49:11) Benefits of Heat Exposure (01:51:10) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, Instagram, Twitter, Neural Network Newsletter Title Card Photo Credit: Mike Blabac Disclaimer

Molecular Mechanisms of Cancer with guest Dr. Daryl Klein March 27, 2022 Yale Cancer Center visit: http://www.yalecancercenter.org email: canceranswers@yale.edu call: 203-785-4095

Molecular Mechanisms of Cancer with guest Dr. Daryl Klein March 27, 2022 Yale Cancer Center visit: http://www.yalecancercenter.org email: canceranswers@yale.edu call: 203-785-4095

Molecular Mechanisms of Cancer with guest Dr. Daryl Klein March 27, 2022 Yale Cancer Center visit: http://www.yalecancercenter.org email: canceranswers@yale.edu call: 203-785-4095

A 2020 review on light therapy mechanisms with neurodegenerative disease is the focus of Dr. Rountree and Kristi's discussion today. Together they review what neurodegeneration is, what light and laser treatment looks like for neurodegeneration diseases, and the cellular mechanisms and the therapeutic effects we expect to see in relation to these mechanisms. Follow along for information on how and why laser therapy works. Dr. Rountree also has a few cautions and information for light and laser therapy clinics in regards to the use of photobiomodulation for neurodegenerative diseases.We have begun live-streaming this podcast. Watch this episode on Facebook right here. See the next episode LIVE in two weeks!Studies mentioned in this episodeThe Molecular Mechanisms of Action of Photobiomodulation Against Neurodegenerative Diseases: A Systematic ReviewYouTube ChannelLaser Therapy InstituteFurther Resources:Success with Laser Therapy Flowchart & Checklist InfographicCheck out these FREE Provider ResourcesRead about laser research on the LTI BlogLearn more about what we offer on the LTI websiteFind out how you can Customize your LTI experienceRelated Podcast for PatientsHealing at the Speed of Light

Lately, investors and researchers have published more and more information on longevity research and development. Investors like Sergey Young or  Christian Angermayer started to bet significant capital on this topic. What is going on in this field on the research side? What are potential applications to increase the Lifespan? And when will those innovations hit the market?In this episode, I had a conversation in December 2021  with Prof. Collin Ewald, ETH Zürich, about his longevity research and the future impact on the pharma industry.In this episode, we talk about: What is the role of the extracellular matrix during aging and longevity? Where is currently the innovation for longevity drug discoveries done? What aging research is going on?The Swiss Society of Ageing and Longevity Research And much more…Who is the expert in the show?Prof. Ewald is Head of the Extracellular Matrix Regeneration Laboratory, Department of Health Sciences and Technology.Collin has a longstanding interest in the molecular biology of healthy aging and age-related pathologies.He is the founder and currently the president of the Swiss Society for Aging Research (www.ssfar.ch). He is named under the top 1000 Longevity Leaders worldwide and the top 15 Longevity Influencers in Switzerland. He has received multiple awards, including NYAS Future Entrepreneur, recognized by the New York Academy of Sciences.Youtube: https://youtu.be/7uH3m6spb_gTimestamps:(00:00) Opening about the situation in Switzerland and Austria in December 2021(05:40) Longevity, Ageing, and the Health Span(07:05) Collin Ewald – Development of Ageing Research since the 90s(10:45) What is Ageing?(16:45) What is the Possible Lifespan of Human Beings? From Stone Age to the Future(20:10) What Factors Changed in Society that helped increase the average Lifespan?(22:45) The Importance of Education on Healthy Aging(26:15) How Education and Research Evolved with the Internet(27:00) Research Focus of the Collin Ewald Lab(33:30) Doubling the Lifespan in lab trials – is it possible to translate the research into human applications?(35:40) How to Translate Research into Products with Spin Outs.(38:00) Spin Outs from the Collin Ewald Lab(47:24) The Role of Extracellular Matrix in Ageing(54:40) The Potential for Applications for Cancer Diagnostic rooted in the research of the Collin Ewald Lab(56:15) How Artificial Intelligence Helps in Research(59:45) The Challenges Longevity Drug Development Faces at the Clinical Stage(01:03:45) The Role of Food & Science in Longevity Research (01:07:45) The Swiss Society of Ageing Research & Health Policies(01:13:00) Development of Life Expectancy(01:17:20) Healthy Ageing and Social Security(01:20:25) Advice to Young People Who Want to Create Lasting Change(01:25:35) The Killer Experiment - How Failure Creates SuccessPodcast Links:Podcast Community: https://lsg2g.substack.com/Community Partner: https://linktr.ee/lsg2gChristian Soschner: https://linktr.ee/soschnerLSG2G Linkedin: https://www.linkedin.com/company/life-science-get2getherSupport the show (https://lsg2g.substack.com/subscribe?)

Host: Hector O. Chapa, MD, FACOG Guest: Sandra Misale, MD Did you know that HER2 mutations can be found in about 4 percent of patients with non-small cell lung cancer (NSCLC)? Although it's not a very common genetic event, it's still important to know how these mutations drive disease progression and how you can treat these NSCLC patients. That's why Dr. Sandra Misale joins Dr. Hector Chapa to explore the clinical features and characteristics of HER2 mutations along with the available therapeutic options.

Dr.SHIVA LIVE: CytoSolve Discovers Molecular Mechanisms of Green Tea Reducing Transplant Rejection. Just Published. Seminal Paper. In this discussion, Dr. SHIVA shares his research at CytoSolve and the breakthrough discovery - that was just published in ..

This week we are diving into the autonomic nervous system, fight-or-flight response, and stress. Resources: Autonomic Nervous System Crash Course Video: https://www.youtube.com/watch?v=71pCilo8k4M Trauma informed yoga video for grounding: https://www.youtube.com/watch?v=V1OtxPbFAec Article “The effects of chronic stress on health: New Insights into the Molecular Mechanisms of Brain-body Communication”: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137920/ Connect with me on Instagram @julhouseholder

In today's program we continue our series on the conservation of humanity, exposing the allopathic cancer industry and examining a far more effective naturopathic alternative. Secondarily will also continue our investigation into the wuhan corona virus. Joining us today is Dr Colleen Huber, a Naturopathic Medical Doctor from Tempe, Arizona. Dr. Huber is the owner and Medical Director of NatureWorksBest Medical Clinic. Her clinic is a natural integrative cancer clinic that focuses on natural, holistic, and integrative alternative cancer treatments. The clinic's metabolic treatments have proven to be an effective alternative to the allopathic cancer treatments of chemotherapy and radiation. Dr. Huber's landmark study on sugar intake in cancer patients was groundbreaking for being the largest and longest such study in humans. Dr. Huber's academic writings have appeared in The Lancet, the International Journal of Cancer Research and Molecular Mechanisms, and other medical journals. Dr. Huber was featured as the Keynote Speaker at the 2015 Euro Cancer Summit, and the World Congress on Cancer Therapy in 2016. She is the President of the Naturopathic Cancer Society, Co-Founder and Secretary of the American Naturopathic Research Institute and the Naturopathic Oncology Research Institute, where she is also a research Fellow. To learn more about Dr Huber and her work please visit her website: https://natureworksbest.com

Today, our guest is Tomomi Shimogori, Team Leader of the Lab for Molecular Mechanisms of Thalamus Development at RIKEN Brain Science Institute in Japan. We speak with her about cortical development, studying development in marmosets, and growing up around the globe.

Dr. Karla Kaun is an Assistant Professor of Neuroscience at Brown University. She received her PhD in Zoology from the University of Toronto and afterward completed a postdoctoral fellowship at the University of California, San Francisco and Howard Hughes Medical Institute – Janelia Farm Research Campus before joining the faculty at Brown. Karla is with us today to tell us all about her journey through life and science.

Dr. James Berger is a Professor in the Department of Biophysics and Biopysical Chemistry at the Johns Hopkins University School of Medicine. He received his PhD in Biochemistry and Structural Biology from Harvard University in 1995. Afterwards he was an independent research fellow at the Whitehead Institute of MIT until 1998. James then joined the faculty at UC Berkeley, where he remained for 15 years until coming to Johns Hopkins University in 2013. James has received many awards and honors during his career, including the National Academy of Sciences Award in Molecular Biology, the American Chemical Society Pfizer Award in Enzyme Chemistry, the American Society for Biochemistry and Molecular Biology Schering-Plough Scientific Achievement Award, a Packard Fellows award, and election to both the American Academy of Arts and sciences and the National Academy of Sciences.

Dr. Louis Muglia is a Professor in the Department of Pediatrics at the University of Cincinnati, as well as the Director for the Center for Prevention of Preterm Birth and the Co-Director of the Perinatal Institute Cincinnati childrens hospital. He received his PhD in Molecular Genetics from the University of Chicago and his MD from the University of Chicago Pritzker School of Medicine. Lou completed his Residency in Pediatrics and a Fellowship in Pediatric Endocrinology at Children's Hospital in Boston. He served as an instructor at the Children's Hospital in Boston and at Harvard Medical School, before accepting a faculty position at Washington University in St. Louis where he worked for over 10 years. Lou spent a few years as a Professor at the Vanderbilt University Medical Center before joining the faculty at the University of Cincinnati. Lou has received many awards and honors during his career, including the Burroughs Wellcome Fund Career Development Award in the Biomedical Sciences, the Society of Pediatric Research Young Investigator Award, and election to the American Society for Clinical Investigation and Association of American Physicians. Lou has also been elected as a Fellow in the American Association for the Advancement of Science and a member in the Institute of Medicine of the National Academy of Sciences. Lou is here with us today to tell us about his journey through life and science.