Podcasts about human gene

Dr. Richard Presser joins the program to share how a lost protocol to restore human dna function can help people restore health. Their research shows that Nano Soma literally helps the human body regain the ability to make its own vitamin C again and to regulate all 48/9 nuclear receptors (which it has not been doing). This remarkable change in body function will allow your body to heal from an endless array of ailments. You can learn more or buy yours at https://iwantmyhealthback.com/sarah   Links Mentioned in previous shows: Try the Amazing Nano Soma line of products and receive a 10% discount at https://iwantmyhealthback.com/sarah EMF products: Protect yourself from damaging EMFs with the sleeping pod or the other amazing mitigation devices. Buy at https://www.ftwproject.com/ref/531/ Consider subscribing: Follow on Twitter @Sarah_Westall Follow on my Substack at SarahWestall.Substack.com See Important Proven Solutions to Keep Your from getting sick even if you had the mRNA Shot - Dr. Nieusma MUSIC CREDITS: “In Epic World” by Valentina Gribanova, licensed for broad internet media use, including video and audio     See on Bastyon | Bitchute | Brighteon | CloutHub | Odysee | Rumble | Youtube | Tube.Freedom.Buzz   Dr. Richard Presser Biography: Richard was born on a farm in country Victoria, Australia. Whilst he loved the country, the connection with native and farm plants and animals this provided as well as the practical skills he learned, he never felt at home in that community. After four years at boarding school in Ballarat, Victoria, he moved to Melbourne to attend University. Apart from 18 months in Adelaide, Melbourne and its nearby surrounds has been his home ever since. After completing his PhD in Materials Engineering, Richard joined IBM in sales and spent some 7 years with the company in sales and management roles. In the mid-80's he joined a small existing consulting and products business and helped grow that business to a A$25M operation in a few short years. It was a pinnacle in his business and financial success. A year or so prior to deciding to sell the company, Richard had an epiphany of sorts, when he realised all the success he had been creating was not addressing a deep void he felt inside himself. So began a search to understand this and shortly thereafter came a crisis that led him to destroy almost everything he had created in his life. This included losing over $1M in a year and experiencing a breakdown in his marriage. In his attempts to make some sense of his life, he investigated many healing modalities and finished up becoming a member of small yoga-based group that morphed into a cult. After some years Richard realised that, although he had learned a lot about spirituality through the group, it was not where the answers lay. The only healing modality that brought any lasting benefit to him was Reiki and through this work became aware of a connection to Archangel Michael. Richard also studied Reiki to be able to heal himself. He continued to investigate other healing modalities and read a broad range of spiritual material as he looked for answers. Despair was a close companion throughout this time, though underlying this was also a sense that it would all work out and make sense. It seemed like a piece of cosmic irony. He was deeply in debt, unemployed with no seeming employment prospects, a desire to keep his children in their schools… A mix that looked like it was never going to work - and yet there was this optimism deep inside him. In investigating the connection he felt to Archangel Michael, he found a resonance with the work being done by Carolyn Evers (www.carolynevers.com). He began to participate in some conference calls with her and this work resonated deeply within him. It began a continuing unfolding that has been in part expressed in his eBook. In more recent times, Richard has been working closely with Carolyn,

What better way to start 2024 than with our 100th episode? We celebrate with Washington Post reporter Gene Park as he professes his love for Kojima games and reflects on his hopes for the future of Metal Gear. Recorded on January 10, 2024.

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This talk was given on October 5th, 2022 at Dartmouth College. For more information please visit thomisticinstitute.org. About the speaker: Fr. Nicanor Austriaco, O.P., completed his Bachelor's Degree (B.S.E.) in Bioengineering, summa cum laude, at the University of Pennsylvania, and then earned his Ph.D. in Biology from M.I.T. in the laboratory of Professor Leonard Guarente, where he was a fellow of the Howard Hughes Medical Institute (HHMI). He was ordained a priest in the Order of Preachers in May of 2004. He completed his Pontifical License in Sacred Theology (S.T.L.) in Moral Theology, summa cum laude, at the Dominican House of Studies in Washington, DC, in 2005, and a Pontifical Doctorate in Sacred Theology (S.T.D.), magna cum laude, at the University of Fribourg in Switzerland, in 2015. Fr. Austriaco currently serves as Professor of Biological Sciences & Professor of Sacred Theology at the University of Santo Tomas in Manila, Philippines. Before this position, he was Professor of Biology and of Theology at Providence College in Providence, Rhode Island. His NIH-funded laboratory at Providence College is investigating the genetics of programmed cell death using the yeasts, Saccharomyces cerevisiae and Candida albicans, as model organisms. Papers describing his research have been published in PLoS ONE, FEMS Yeast Research, Microbial Cell, Cell, the Journal of Cell Biology, and the Proceedings of the National Academy of Sciences USA, among others. In philosophy and theology, his essays have been published in the National Catholic Bioethics Quarterly, Theological Studies, Nova et Vetera, The Thomist, Science and Theology, and the Linacre Quarterly. His first book, Biomedicine and Beatitude: An Introduction to Catholic Bioethics, was published by the Catholic University of America Press in 2011. It was recognized as a 2012 Choice outstanding academic title by the Association of College and Research Libraries.

In this episode, Rebecca Megson-Smith talks to Eben Kirksey, American anthropologist and Associate Professor at Alfred Deakin Institute in Melbourne, Australia. Rebecca and Eben discuss his latest book 'The Mutant Project: Inside the Global Race to Genetically Modify Humans', the work of Dr. Jiankui He, who created the first genetically modified babies, and the moral dilemmas this work has since raised, with a particular focus on the values behind gene-editing and the implications for society. Intro music: Cold by yoitrax | @yoitrax Music promoted by www.free-stock-music.com Creative Commons Attribution 3.0 Unported License creativecommons.org/licenses/by/3.0/deed.en_US

Now that we've gotten a look at the genomes of archaic humans, researchers are trying to determine whether our differences are due to genetics.Â

Life matters, just ask this (Wo)man whoo beat the odds not once, but twice! Third time is a charm when you're on a mission to leave a legacy for every hooman that you meet.It OWL started with the Ovarian Cancer project, whoo's on a mission to support (Wo)men that aren't sure how much life they have left to give our world because #cancersucks BUT love and hope make OWL the difference to the one whoo's world is on fire in their body, heart, mind, spirit and soul. At least that's OWL she was doing, but then "the man" stepped in with his papers and products and tried to sell our shared humanity to the highest bidder, AGAIN. But I digress...Tune in, turn on and give a hoot about hoomans struggling with Ovarian Cancer because some dumb idiot forgot that this is ONE shared humanity and we no longer sell hoomans and their future offspring for profit. And put those little greenbacks to work, put a little love in your heart, and invest in (Wo)men around the world whoo need a little love and hope in their lives right now at https://ovariancancerproject.org/Advocate, Partner, and LOVE sharing your gifts (and money) with hoomans whoo need it this Valentine's Day and make a wish that commercials stop showing diamonds this day and begin shining a light on the diamonds in the rough that OWL-ready exist right in front of you. Spoiler alert, mining for diamonds is called Murder on the streets for those whoo are woke to what's going on over there. Put hoomans to work and have the make those fake diamonds that employee people instead of enslaving them in a system that wasn't built for shared hoomanity. 

Recently, the Nobel prize in Chemistry was awarded to Emmanuelle Charpentier and Jennifer Doudna “for the development of a method for genome editing”. In this episode, Dr. Dagan Wells reviews CRISPR gene editing technology and discusses the ethical and biological challenges of human gene editing, as well as its very promising potential. Podcast website: https://www.ivi-rmainnovation.com/?utm_source=podcast&utm_medium=episode&utm_campaign=ep15  

In this episode, we explore the world of epigenetics testing with Dr. Erika Gray, PharmD of Toolbox Genomics. Learn what health markers play a role in our long-term health and why your standard DNA test may not be enough. Epigenetics are expressions of your DNA, impacted by your lifestyle and environment. The respective genes can be turned ’on’ or ‘off’ through targeted lifestyle interventions, which can be tracked with repeat testing.ABOUT TOOLBOX GENOMICS:Toolbox Genomics is a data interpretation service. They take genetic data generated by a CLIA/CAPP certified lab and compare it against hundreds of genetic markers that our research team has identified as significant. The company also has a comprehensive data protection privacy policy, which you can find outlined on their website. Use promocode B&B7 for 7% savings on your test kit that you can buy here! (We like the epigenetic and nourish test kits the most!)Website: https://www.mytoolboxgenomics.comABOUT BEAUTY & THE BIOHACKER:Learn more: beautyandthebiohacker.comEmail us at info@beautyandthebiohacker.comABOUT RACHEL & KATIE:Learn more with Rachel Varga BScN, RN, CANS, Board Certified Aesthetic Nurse Specialist https://RachelVarga.caBOOK YOUR ONE ON ONE Virtual Skin and Aging Consultation with Rachel Varga here: https://RachelVarga.ca/get-startedLearn more with Katie Type A: https://katietypea.comCheck out Katie Type A's YouTube Channel: https://bit.ly/3le3MUJDISCLAIMER: Information in this podcast and interview is not to be taken as medical advice, and always consult with your Physician before making any lifestyle changes. The material shared by guests in this podcast is not the opinion of Rachel Varga or Katie Moore, and disclaims any responsibility of inaccurate credentials of guests or information used that may cause harm. Always consult with your licensed Physician before any lifestyle modifications.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.15.340802v1?rss=1 Authors: Pantazis, Y., Tselas, C., Lakiotaki, K., Lagani, V., Tsamardinos, I. Abstract: High-throughput technologies such as microarrays and RNA-sequencing (RNA-seq) allow to precisely quantify transcriptomic profiles, generating datasets that are inevitably high-dimensional. In this work, we investigate whether the whole human transcriptome can be represented in a compressed, low dimensional latent space without loosing relevant information. We thus constructed low-dimensional latent feature spaces of the human genome, by utilizing three dimensionality reduction approaches and a diverse set of curated datasets. We applied standard Principal Component Analysis (PCA), kernel PCA and Autoencoder Neural Networks on 1360 datasets from four different measurement technologies. The latent feature spaces are tested for their ability to (a) reconstruct the original data and (b) improve predictive performance on validation datasets not used during the creation of the feature space. While linear techniques show better reconstruction performance, nonlinear approaches, particularly, neural-based models seem to be able to capture non-additive interaction effects, and thus enjoy stronger predictive capabilities. Our results show that low dimensional representations of the human transcriptome can be achieved by integrating hundreds of datasets, despite the limited sample size of each dataset and the biological / technological heterogeneity across studies. The created space is two to three orders of magnitude smaller compared to the raw data, offering the ability of capturing a large portion of the original data variability and eventually reducing computational time for downstream analyses. Copy rights belong to original authors. Visit the link for more info

During this episode, Dean Jacob Rooksby visits with Sandra Park. Sandra is a senior attorney with the ACLU Women’s Rights Project. Her work focuses on advancing gender equality and challenging discrimination experienced by survivors of gender-based violence, and she was also counsel on the ACLU’s successful 2013 U.S. Supreme Court challenge to human gene patents. During this conversation, she shares her insights and experience with the case.

Journalist, author, and consent expert, Vanessa Grigoriadis with expert in Asian affairs and biotechnology, Jamie Metzl, discuss everything about the future and predictions of editing genes.

How should we prepare for rapid advancement of gene editing technology? This month on Ethics Talk, Dr Sean C. McConnell provides an introduction to gene editing and CRISPR technology and Scott J. Schweikart discusses what prudent governance requires.

In November 2018, a Chinese scientist announced the birth of the world's first gene-edited babies and sparked outrage across the world. Professor Nie considers how China's complex socio-ethical approach paved the way for this controversial experiment. Among numerous ethical issues, editing heritable germline genomes of otherwise healthy embryos for natural resistance to HIV constitutes an effort of positive eugenics, i.e. not treating disease but enhancing genetic features. This paradigm case of scientific misconduct has its roots in the widespread practice of yousheng (eugenics) in China and in the nation's pursuit of science superpower status. This talk will offer a (brief) socio-ethical inquiry into how the ideologies of nationalism, sinicised social Darwinism and scientism have shaped the Chinese authoritarian model of human genetic engineering in a global context.

In November 2018, a Chinese scientist announced the birth of the world’s first gene-edited babies and sparked outrage across the world. Professor Nie considers how China's complex socio-ethical approach paved the way for this controversial experiment. Among numerous ethical issues, editing heritable germline genomes of otherwise healthy embryos for natural resistance to HIV constitutes an effort of positive eugenics, i.e. not treating disease but enhancing genetic features. This paradigm case of scientific misconduct has its roots in the widespread practice of yousheng (eugenics) in China and in the nation’s pursuit of science superpower status. This talk will offer a (brief) socio-ethical inquiry into how the ideologies of nationalism, sinicised social Darwinism and scientism have shaped the Chinese authoritarian model of human genetic engineering in a global context.

What used to take PhD’s weeks and months to do, now takes people at an undergraduate level just a few hours to do. Gene programming consists of editing human microbes on a molecular level to produce a desired outcome. Ginkgo Bioworks is the leading company in the field of synthetic biology with a private valuation … Continue reading Human Gene Programming… We Agree, It’s Weird. →

In this episode:01:01 Breaking NewsThe first image of a black hole took the world by storm, but what was it like reporting such a quickly developing story? News: Black hole pictured for first time — in spectacular detail; Video: The first image of a black hole: A three minute guide; Video: How scientists reacted to the first-ever image of a black hole09:01 Digital JournalismWhen a new research paper came to light about pig brains being revived, we asked our audience what they wanted to know, and got a big response. Could this be the future of journalism? News: Pig brains kept alive outside body for hours after death; News Explainer: Disembodied pig brains revived: Your questions answered15:09 The Future of gene editingWith yet more stories emerging of the editing of human embryos, we discuss the ethical implications and what should happen next? News Feature: CRISPR babies: when will the world be ready?; News: Russian biologist plans more CRISPR-edited babies See acast.com/privacy for privacy and opt-out information.

The Chain Method!? No, I'm not talking about Fleetwood Mac. Human gene editing!? Yes, it's exactly as terrifying as it sounds. The world has an important decision to make: will our future be Utopian or Dystopian? Through "right action" and re-orientation the obvious answer is easily attainable. Make good decisions, build on your momentum, and before you know it you'll be rolling in positivity. Once you create, you should never break the chain!

New York Times staff writer Pam Belluck discusses the WHO and regulation on human gene editing. Read her March 19, 2019, article here: https://www.nytimes.com/2019/03/19/health/who-panel-demands-a-registry-for-human-gene-editing.html. 

Hi, hello and welcome to another amazing episode from Nerds Amalgamated. Once again we enjoy bringing you this slice of entertainment from the world of the NERD pop culture news, where all are welcome. We pause for a moment to pay our respect to the victims of the cowardly bombings in Sri Lanka over Easter. Also we pause to honour the ANZACs, those individuals who have helped defend Australia and New Zealand for over a century. First topic is from the Professor, and it is about an open source game making program that enables the creation of 8-bit type games. Useable on web-browsers and portable devices such as the Nintendo Gameboy (All trademarks acknowledged – so don’t sue us please Nintendo, Buck is still not happy with you). This is looking like a fun way of making your own games and also introducing coding and game development to a new generation. Then we look at a birthday celebration for Batman, 80 years old and still giving crime a beat down. Yep, there is a return of the quadrilogy from the 90’s to cinemas. So grab you friends, dig those happy pants out of the cupboard and shake up that hair spray and head on down. You get to see the two Michael Keaton Batman movies, followed by Val Kilmer and then George Clooney. We discuss Bat-nipple gate and how fun these movies were. Plus we hear how tragic Buck was at decorating his bedroom as a teenager. Next up we look at further plans to make use of CRISPR for gene editing, this time to prevent hereditary diseases. Say hi to the start of Gattaca folks, we have a group of mad scientists running around with questionable ethics who don’t watch movies. Next they will be telling us about how they want to remake dinosaurs and release them into the wild, like that other movie. Don’t these people ever learn to think about the consequences of their actions? We finish off with the usual shout out, remembrances, birthdays and events. As always take care of each other and stay hydrated.EPISODE NOTES:Sri Lankan Easter Bombing - https://en.wikipedia.org/wiki/2019_Sri_Lanka_Easter_bombingsAnzac Day - https://en.wikipedia.org/wiki/Anzac_DayGB Studios - https://www.gbstudio.dev/ - https://www.reddit.com/r/programming/comments/bg1xej/gb_studio_is_an_opensource_visual_game_maker_to/Original Batman Quadrilogy - https://screenrant.com/batman-original-movie-quadrilogy-returning-theaters/CRISPR Human Gene Editing - http://discovermagazine.com/2019/may/repairing-the-futureGames Currently playingDJ– Mortal Kombat 11 – https://store.steampowered.com/app/976310/Mortal_Kombat11/Buck– Assassin’s Creed Unity - https://store.steampowered.com/app/289650/Assassins_Creed_Unity/Professor– Adrenaline the board game - https://boardgamegeek.com/boardgame/202408/adrenalineOther topics discussedAnzac Day road closures- https://www.couriermail.com.au/news/queensland/full-list-of-anzac-day-road-closures-in-brisbane/news-story/21e0848fde4b685faaa4a416adf98018Nintendo shuts down Emuparadise - https://www.extremetech.com/gaming/275146-retro-gaming-site-emuparadise-shuts-down-as-nintendo-hits-the-warpathNintendo shuts down Pokemon Uranium- https://www.polygon.com/2016/8/14/12472616/pokemon-uranium-taken-down-nintendoNintendo takes down Commodore 64 Remake of Super Mario Bros- https://www.kotaku.com.au/2019/04/nintendo-takes-down-c64-remake-of-super-mario-bros/Batman Movies- Batman (1989 film) - https://en.wikipedia.org/wiki/Batman_(1989_film)- Batman Returns (1992 film) - https://en.wikipedia.org/wiki/Batman_Returns- Batman Forever (1992 film) - https://en.wikipedia.org/wiki/Batman_Forever- Batman & Robin (1995 film) - https://en.wikipedia.org/wiki/Batman_%26_Robin_(film)Joker actors in Batman movies and other media- Jack Nicholson (1989 Batman film Joker) - https://en.wikipedia.org/wiki/Jack_Nicholson- Heath Ledger (2008 Batman film Joker) - https://en.wikipedia.org/wiki/Heath_Ledger- Mark Hamill (1992 Batman: The Animated Series Joker) - https://en.wikipedia.org/wiki/Mark_HamillAlicia Silverstone (Batgirl in Batman & Robin 1997)- https://en.wikipedia.org/wiki/Alicia_SilverstoneActors portraying as Batman- Michael Keaton (1989 & 1992 Batman) - https://en.wikipedia.org/wiki/Michael_Keaton- Val Kilmer (1992 Batman) - https://en.wikipedia.org/wiki/Val_Kilmer- George Clooney (1997 Batman) - https://en.wikipedia.org/wiki/George_ClooneyGattaca (1997 film)- https://en.wikipedia.org/wiki/GattacaDynamite also known as TNT – TriNitroToluene is a compound in dynamite but is not the same, there is another piece of trivia you can use in the trivia night to stump people- https://en.wikipedia.org/wiki/DynamiteGuided bombs also known as Smart bombs, but smart bombs also have many other variants ranging from types of explosions, for example the bunker busters, to warhead variants on ICBMs which separate and loose multiple strikes over an extended area or separate targets.- https://en.wikipedia.org/wiki/Guided_bombEugenics- https://en.wikipedia.org/wiki/EugenicsBrave New World by Aldous Huxley- https://en.wikipedia.org/wiki/Brave_New_WorldU.N findings: US Forces kill more Afghan Civilians than ISIS & Taliban in 2019- https://www.commondreams.org/news/2019/04/24/unprecedented-un-finds-us-backed-forces-killed-more-afghan-civilians-taliban-and?fbclid=IwAR3xU6beak4Ega5DO8VeaoF77-Mn3lPSR6m5E_Ibg8lhTPMYgC4MHkSoeiAImage comparison of Mortal Kombat Sonya Blade (MK 9 vs MK 11)- https://am21.akamaized.net/tms/cnt/uploads/2019/01/Sonya-Blade.jpgFrank Welker (voice actor)- https://en.wikipedia.org/wiki/Frank_WelkerCary-Hiroyuki Tagawa (actor)- https://en.wikipedia.org/wiki/Cary-Hiroyuki_TagawaMK 11 Skins total cost = $6440- https://www.vg247.com/2019/04/24/mortal-kombat-11-skin-price-6440/Ed Boon’s response to total cost of MK 11 skins- https://twitter.com/noobde/status/1121243237388357632Mortal Kombat 11 voice cast list- https://www.imdb.com/title/tt9398566/Master Chief (Halo character)- https://en.wikipedia.org/wiki/Master_Chief_(Halo)Last chance to download Assassin’s Creed Unity for free (Now expired)- https://www.gamespot.com/articles/last-chance-to-get-assassins-creed-unity-for-free-/1100-6466327/Star Trek Beyond (2016 film) - https://en.wikipedia.org/wiki/Star_Trek_BeyondDid Shakespeare write his own plays- https://www.history.com/news/did-shakespeare-really-write-his-own-playsShirley Temple (drink)- https://en.wikipedia.org/wiki/Shirley_Temple_(drink)Email Bomb (internet virus)- https://en.wikipedia.org/wiki/Email_bombMonkey selfie copyright dispute- https://en.wikipedia.org/wiki/Monkey_selfie_copyright_disputeKanellos Kanellopoulos (Greek cyclist who piloted the 1988 MIT Daedalus project)- https://en.wikipedia.org/wiki/Kanellos_KanellopoulosShoutouts20 Apr 1887 - World's First Motor Race, Georges Bouton “won the world’s first motor race” with a steam-powered quadricycle. The event was a “test” organised by the newspaper Le Velocipede to see if Bouton’s machine, which had boasted speeds of 60kmph, could make the 29-kilometre distance between Neuilly Bridge in Paris and the Bois de Boulogne. Bouton and de Dion completed the test course in 1 hour and 14 minutes riding La Marquise, the quadricycle named after the aristocrat’s mother. - https://www.onthisday.com/articles/the-worlds-first-motor-race14 Apr 2019 – 1000th Formula 1 Grand Prix race at Shanghai, China - https://www.formula1.com/en/latest/article.top-shots-the-drivers-1000th-race-helmet-designs.nFP8yFNcrzI7yybxLMUXs.html23 Apr 2013 - "Star Trek Into Darkness" directed by J. J. Abrams starring Chris Pine and Zachary Quinto premieres in Sydney - https://www.startrek.com/article/star-trek-into-darkness-premieres-in-australia23 Apr 2018 - Marvel's "Avengers: Infinity War" directed by Anthony and Joe Russo, starring Chris Evans, Robert Downey Jr and large ensemble cast premieres in Los Angeles - https://variety.com/2018/film/news/avengers-infinity-war-premiere-marvel-1202784555/Remembrances22 Apr 2019 - Kiyoshi Kawakubo, Japanese voice actor, his prominent anime roles include Guame in Gurren Lagann, Kevin Yeegar in D.Gray-man, Quincy in Bubblegum Crisis and Scramble Wars. He passed away on 16 Apr 2019 at 89 - https://en.wikipedia.org/wiki/Kiyoshi_Kawakubo- https://www.animenewsnetwork.com/news/2019-04-22/voice-actor-kiyoshi-kawakubo-passes-away/.14598423 Apr 1616 - William Shakespeare, English poet, playwright and actor, widely regarded as the greatest writer in the English language and the world's greatest dramatist. His extant works, including collaborations, consist of approximately 39 plays, 154 sonnets, two long narrative poems, and a few other verses, some of uncertain authorship. His plays have been translated into every major living language and are performed more often than those of any other playwright. He died of a fever at 52 in Stratford-upon-Avon, Warwickshire - https://en.wikipedia.org/wiki/William_Shakespeare23 Apr 1850 - William Wordsworth, English Romantic poet who, with Samuel Taylor Coleridge, helped to launch the Romantic Age in English literature with their joint publicationLyrical Ballads. Wordsworth's magnum opus is generally considered to be The Prelude, a semi-autobiographical poem of his early years that he revised and expanded a number of times. Wordsworth was Britain's poet laureate from 1843 to 1850. He died of aggravated case of pleurisy at 80 in Rydal, Westmorland - https://en.wikipedia.org/wiki/William_WordsworthBirthdays23 Apr 1901 – E.B Ford, British ecological geneticist. He was a leader among those British biologists who investigated the role of natural selection in nature. As a schoolboy Ford became interested in lepidoptera, the group of insects which includes butterflies and moths. He went on to study the genetics of natural populations, and invented the field of ecological genetics. He was born in Dalton-in-Furness, Lancashire - https://en.wikipedia.org/wiki/E._B._Ford26 Apr 1616 - William Shakespeare, same as above, he baptised in Stratford-upon-Avon, Warwickshire - https://en.wikipedia.org/wiki/William_Shakespeare23 Apr 1928 – Shirley Temple, American actress, singer, dancer, businesswoman, and diplomat who was Hollywood's number one box-office draw as a child actress from 1935 to 1938. As an adult, she was named United States ambassador to Ghana and to Czechoslovakia, and also served as Chief of Protocol of the United States. Temple began her film career at the age of three in 1932. Two years later, she achieved international fame in Bright Eyes, a feature film designed specifically for her talents. She appeared in 14 films such as Heidi and Curly Top from the ages of 14 to 21. Temple retired from film in 1950 at the age of 22. She began her diplomatic career in 1969, when she was appointed to represent the United States at a session of the United Nations General Assembly, where she worked at the U.S Mission under Ambassador Charles W. Yost. Temple was the recipient of numerous awards and honors, including the Kennedy Center Honors and a Screen Actors Guild Life Achievement Award. She is 18th on the American Film Institute's list of the greatest female American screen legends of Classic Hollywood cinema. She was born in Santa Monica, California - https://en.wikipedia.org/wiki/Shirley_Temple23 Apr 1941 - Ray Tomlinson, a pioneering American computer programmer who implemented the first email program on the ARPANET system, the precursor to the Internet, in 1971; he is internationally known and credited as the inventor of email. It was the first system able to send mail between users on different hosts connected to ARPANET. Previously, mail could be sent only to others who used the same computer. To achieve this, he used the @ sign to separate the user name from the name of their machine, a scheme which has been used in email addresses ever since.[9] The Internet Hall of Fame in its account of his work commented "Tomlinson's email program brought about a complete revolution, fundamentally changing the way people communicate". He was born in Amsterdam, New York - https://en.wikipedia.org/wiki/Ray_TomlinsonEvents of Interest23 Apr 1516 - German Beer Purity Law or Reinheitsgebot, is a series of regulations limiting the ingredients used to brew beer in Germany and the states of the former Holy Roman Empire. - https://en.wikipedia.org/wiki/Reinheitsgebot- https://www.onthisday.com/photos/german-beer-purity-law23 Apr 2005 - The first ever YouTube video, titled "Me at the zoo", was published by user "jawed". It was uploaded on April 23, 2005 at 20:27:12 PTD (April 24, 2005 at 3:27:12 UTC) by the site's co-founder Jawed Karim, with the username "jawed" and recorded by his high school friend Yakov Lapitsky. He created a YouTube account on the same day. The nineteen-second video was shot by Yakov at the San Diego Zoo, featuring Karim in front of the elephants in their old exhibit in Elephant Mesa, making note of their lengthy trunks. - https://en.wikipedia.org/wiki/Me_at_the_zoo - First ever YouTube video “Me at the Zoo” - https://www.youtube.com/watch?v=jNQXAC9IVRw23 Apr 1988 – A Greek makes world record with the MIT Aeronautics and Astronautics Department's Daedalus, a human-powered aircraft flew a distance of 72.4 mi (115.11 km) in 3 hours, 54 minutes, from Heraklion on the island of Crete to the island of Santorini. The flight holds official FAI world records for total distance, straight-line distance, and duration for human-powered aircraft. - https://en.wikipedia.org/wiki/MIT_DaedalusIntroArtist – Goblins from MarsSong Title – Super Mario - Overworld Theme (GFM Trap Remix)Song Link - https://www.youtube.com/watch?v=-GNMe6kF0j0&index=4&list=PLHmTsVREU3Ar1AJWkimkl6Pux3R5PB-QJFollow us on Facebook - https://www.facebook.com/NerdsAmalgamated/Email - Nerds.Amalgamated@gmail.comTwitter - https://twitter.com/NAmalgamatedSpotify - https://open.spotify.com/show/6Nux69rftdBeeEXwD8GXrSiTunes - https://itunes.apple.com/au/podcast/top-shelf-nerds/id1347661094RSS - http://www.thatsnotcanonproductions.com/topshelfnerdspodcast?format=rss

Razib Khan joins the Urbane Cowboys podcast once again to discuss Crispr gene editing of humans. Will we eliminate diseases, create a master race, or choose vibrant new skintones? Co-hosted by Josiah Neeley of R Street Institute and Doug McCullough of Lone Star Policy Institute. Produced by Ray Ingegneri.

UC San Diego Professor of Pediatrics and Computer Science & Engineering Rob Knight illustrates the enormous presence of the microbiome in humans. Knight is presented by the Library Channel at UC San Diego. Series: "Library Channel" [Health and Medicine] [Humanities] [Show ID: 33434]

UC San Diego Professor of Pediatrics and Computer Science & Engineering Rob Knight illustrates the enormous presence of the microbiome in humans. Knight is presented by the Library Channel at UC San Diego. Series: "Library Channel" [Health and Medicine] [Humanities] [Show ID: 33434]

UC San Diego Professor of Pediatrics and Computer Science & Engineering Rob Knight illustrates the enormous presence of the microbiome in humans. Knight is presented by the Library Channel at UC San Diego. Series: "Library Channel" [Health and Medicine] [Humanities] [Show ID: 33434]

UC San Diego Professor of Pediatrics and Computer Science & Engineering Rob Knight illustrates the enormous presence of the microbiome in humans. Knight is presented by the Library Channel at UC San Diego. Series: "Library Channel" [Health and Medicine] [Humanities] [Show ID: 33434]

The challenge for the first ever in-human gene editing trial, according to today’s guest, is with the delivery to the body. “At the moment, the easiest place to deliver your gene or genome editing is to the liver, using AAV which are viruses that seek out and go to the liver cells," says Sandy Macrae, the CEO of Sangamo Therapeutics. Sangamo is known for two things: They have pioneered the commercialization of an older gene editing technology called Zinc Fingers. And they have done a lot of work in the area of HIV.

Reviewing the arguments that homosexuality is bad from a logical perspective, can it be done? What science says about homosexuality. With a special guest, Gary provides us with an LGBTQ perspective, and has a lifetime of stories to tell as a gay man in the US. Gay swanhttps://en.wikipedia.org/wiki/Homosexual_behavior_in_animals https://www.livescience.com/1125-homosexual-animals-closet.html https://www.youtube.com/watch?v=n5LVunYzM5M   How does homosexuality contribute to the human gene pool?  And how is it considered a vitial contributor to our species?  Listen to find out more.

James Noonan, Assistant Professor of Genetics at Yale School of Medicine, focuses on identifying changes in gene regulation during early embryonic development that contributed to the evolution of uniquely human biological traits. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 21988]

James Noonan, Assistant Professor of Genetics at Yale School of Medicine, focuses on identifying changes in gene regulation during early embryonic development that contributed to the evolution of uniquely human biological traits. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 21988]

Relationships between genes and social behavior have historically been viewed as a one-way street, with genes in control. Recent analyses have challenged this view by discovering broad alterations in the expression of human genes as a function of differing socio-environmental conditions. My talk summarizes the developing field of social genomics, and its efforts to identify the types of genes subject to social regulation, the biological signaling pathways mediating those effects, and the genetic polymorphisms that moderate socio-environmental influences on human gene expression. This approach provides a concrete molecular perspective on how external social conditions interact with our genes to shape the functional characteristics of our bodies, and alter our future biological and behavioral responses based on our personal transcriptional histories. (March 25, 2014)

Relationships between genes and social behavior have historically been viewed as a one-way street, with genes in control. Recent analyses have challenged this view by discovering broad alterations in the expression of human genes as a function of differing socio-environmental conditions. My talk summarizes the developing field of social genomics, and its efforts to identify the types of genes subject to social regulation, the biological signaling pathways mediating those effects, and the genetic polymorphisms that moderate socio-environmental influences on human gene expression. This approach provides a concrete molecular perspective on how external social conditions interact with our genes to shape the functional characteristics of our bodies, and alter our future biological and behavioral responses based on our personal transcriptional histories. (March 25, 2014)

If babies are born by caesarian and modern medicine allows many more people to survive to adulthood, will the human gene pool be affected? We explore this huuuge question in a very concise Question of the Week. Plus, we ask why it is that wine and cheese complement each other so well. Like this podcast? Please help us by supporting the Naked Scientists

Human-Specific Signaling Networks (Genevieve Konopka); Uniquely Human Gene Regulation (James Noonan); Human-Specific Changes in Siglec Genes (Ajit Varki) Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 21958]

Human-Specific Signaling Networks (Genevieve Konopka); Uniquely Human Gene Regulation (James Noonan); Human-Specific Changes in Siglec Genes (Ajit Varki) Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 21958]

Uniquely Human Gene Regulation (James Noonan); A Comparative Study of Immune Response in Primates (Yoav Gilad); Human-Specific Changes in Siglec Genes (Ajit Varki) Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 21957]

Uniquely Human Gene Regulation (James Noonan); A Comparative Study of Immune Response in Primates (Yoav Gilad); Human-Specific Changes in Siglec Genes (Ajit Varki) Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 21957]

Real design vs. appearance?; Human genes decaying?; Inter-family marriage?; Keys to the kingdom?

On episode #73 of the podcast This Week in Virology, Vincent, Dickson, and Rich discuss multipotent progenitor bone marrow cells as a reservoir of HIV-1, integration of HHV-6 into telomeres, and dispersal of West Nile virus across the US by mosquitoes. Host links Vincent Racaniello, Dickson Despommier, and Rich Condit Links for this episode: HIV-1 infects multipotent progenitor cells HHV-6 genome integrates into telomeres A role for mosquito-mediated dispersal of West Nile virus across the US Using tobacco mosaic virus to produce synthetic photovoltaic cells (thanks Nissin!) Animation of HIV replication cycle (thanks Ilya!) Can computer viruses evolve? (thanks Norman!) Mumps outbreak in Israel (one and two) (thanks Ariel!) Bocavirus infections in children (thanks Tyler!) Weekly science picks: Dickson Whole-Genome Sequencing in a Patient with Charcot–Marie–Tooth Neuropathy (NEJM and NY Times) Rich Invisible Frontiers: The Race to Synthesize a Human Gene by Stephen Hall Vincent Conference on Retroviruses and Opportunistic Infections - videocasts

IP & Public Health

Vectors based on adeno-associated virus type 2 (AAV) offer considerable promise for somatic gene therapy of various diseases (e.g. cystic fibrosis, hemophilia B, cancer). Limitations, however, still exist and require further improvement. The study presented here addresses two major problems that hamper a widespread use of AAV in human gene therapy: First, the loss of site-specific integration of recombinant AAV vectors (rAAV) due to the deletion of the rep gene, and secondly, the potential neutralization of AAV gene therapy vectors by preexisting antibodies. It could be demonstrated that site-specific integration of a transgene encoding rAAV vector can be efficiently restored by providing rep as plasmid DNA in trans. Based on these findings, a rAAV vector was developed where a plasmid coding for Rep was coupled as polylysine/DNA complex (PLL/DNA) directly to the capsid of the virion and co-transduction of such a PLL/DNA coupled to AAV was shown. Thus, providing rep-DNA as PLL/DNA should allow rAAV vectors to integrate specifically at chromosome 19. To characterize immunogenic domains of the AAV capsid and to develop strategies to circumvent neutralization by antibodies, AAV capsid mutants carrying peptide insertions in surface exposed loop regions were investigated in binding and neutralization assays. Three positions could be identified in the AAV capsid (at aa 534, 573, and 578 of the VP1 protein) where binding and neutralization of the virus by human serum samples was markedly reduced. These result suggest that capsid modifications could help to overcome binding and neutralization by human antisera in clinical gene therapy applications.