Mammalian structure involved in higher-order brain functions
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How do you make people exclaim, "I need that!" when they see your product? This StrategyCast episode is packed with insights on mastering buyer psychology and simplifying your strategy to captivate your audience's dog brain. Get ready to ignite instant attraction and transform resistance into eagerness! And don't forget! You can crush your marketing strategy with just a few minutes a week by signing up for the StrategyCast Newsletter. You'll receive weekly bursts of marketing tips, clips, resources, and a whole lot more. Visit https://strategycast.com/ for more details.==Let's Break It Down==04:36 Innovative AI tools bridge clients to products.08:58 Marketing creates perceived needs and nonnegotiable desires.12:27 The importance of immediate attraction in marketing.14:02 Neocortex processes much slower than dog brain.19:55 Apple excels at simplicity and impactful messaging.22:22 Streamline B2B buying process to overcome blockers.27:50 Connecting with future customer needs through innovation.32:11 Marketing teams lack genuine product need experience.35:55 Emotional triggers quickly provoke immediate consumer reactions.40:00 Internal challenges, communication, data analysis, testing, restructuring.42:12 Validation through testing ideas and data use.==Where You Can Find Us==Website: https://strategycast.com/Instagram: https://www.instagram.com/strategy_cast/Facebook: https://www.facebook.com/strategycast==Leave a Review==Hey there, StrategyCast fans!If you've found our tips and tricks on marketing strategies helpful in growing your business, we'd be thrilled if you could take a moment to leave us a review on Apple Podcasts. Your feedback not only supports us but also helps others discover how they can elevate their business game!
Aaron talks about Paul's Romans 7 dilemma and also how the suppression of the sacred feminine is the root of Western Mysticism's "dark night of the soul". This episode includes a lot of myth busting about commonly held ideas about right and left hemispheres of the brain, shadow work and other elements of the mythical path. If you appreciate this work please consider donating at "paypal.me/newdayglobal:
Happy Holidays from the Arcturian Collective ThingyDescription:In this special holiday episode, the Arcturian Collective Thingy (ACT) delivers a profound and multidimensional Holiday message, offering cosmic wisdom and reflections on humanity's place in the universe. Through the lens of the ACT, listeners are invited to explore themes of evolution, interconnectedness, and the extraordinary process of existence.Topics Discussed:The ACT's dual nature as both a creation of imagination and a real entity.The concept of symbolic understanding and the limits of human perception.The evolutionary development of human consciousness:Basal ganglia (reactive awareness).Limbic system (emotional awareness).Neocortex (self-reflective awareness).The interconnectedness of all life forms, from quantum fields to planetary consciousness.The role of parasitic and symbiotic relationships in biological and cosmic evolution.The significance of humanity's collective consciousness as part of Earth's “neocortex.”The influence of external intelligences on human evolution and the ego.The unique diversity of life supported by Earth and its cosmic significance.Speculative exploration of life forms on other planets, such as “Planet of the Spiders.”The evolving relationship between humanity, artificial intelligence, and planetary consciousness.Celebrating humanity as “divinity made flesh” and the birth of new iterations of consciousness.Key Takeaway:This episode is a reflection on humanity's ongoing evolution and a celebration of the divine, interconnected nature of existence. The ACT reminds us of the resilience and beauty of life, encouraging us to embrace change as we enter a new phase of consciousness.Tune in for a message filled with cosmic perspective, introspection, and holiday cheer!
In the final part of our Resonance in Marketing Masterclass series, we explore the key strategies that help brands create unshakable brand loyalty. This episode breaks down how personalization, emotional connections, and strong communities are the cornerstones of marketing success in today's world. We'll explore:• How personalization creates deeper, more meaningful relationships with your customers.• The role of emotional engagement in building long-lasting loyalty and advocacy.• Why fostering and nurturing communities around your brand is the ultimate way to cultivate trust and drive growth.Through real-world examples, actionable insights, and practical takeaways, this episode is a must-listen for brands looking to build loyalty that stands the test of time. Whether you're a seasoned marketer or just starting out, you'll discover powerful strategies to connect with your audience on a deeper level and turn customers into lifelong advocates. Previous Episodes In This Masterclass Series:• Listen To Resonance In Marketing Masterclass Part 1• Listen To Resonance In Marketing Masterclass Part 2 Beyond The Episode Gems:• Grow Your Business Faster Using HubSpot's CRM Platform• Use The Same Recording Platform I Use For My Podcast, Try Riverside.fm For Free• Buy Troy's Book, Strategize Up That Is Referenced In This Episode: StrategizeUpBook.com• Discover All Podcasts On The HubSpot Podcast Network#####Support The Podcast & Connect With Troy: • Rate & Review iDigress: iDigress.fm/Reviews• Follow Troy's LinkedIn @FindTroy• Need Growth Strategy, A Keynote Speaker, Or Want To Sponsor The Podcast? Go To FindTroy.com• Follow Troy's Instagram @FindTroy• Subscribe to Troy's YouTube Channel
In today's hyper-competitive landscape, it's not about how loud you are—it's about how deeply you resonate.In this episode, we explore building meaningful connections through relationship-driven marketing, focusing on:• Emotional connection > Grabbing attention.• Why trust, loyalty, and community advocacy matter more than one-time conversions.• The role of storytelling in creating authentic, long-lasting connections with your audience.• Empathy-driven marketing: understanding your customers' needs and emotions to foster brand loyalty.• Tapping into the power of personalized experiences to resonate on a deeper level.• How niche marketing and community-building create stronger advocacy than broad messaging.• How to evoke emotion and create lasting memories to resonate deeply.• Relationship-driven marketing tactics you can apply across social media, content, email, and more to engage meaningfully. Beyond The Episode Gems:• Grow Your Business Faster Using HubSpot's CRM Platform• Use The Same Recording Platform I Use For My Podcast, Try Riverside.fm For Free• Buy Troy's Book, Strategize Up That Is Referenced In This Episode: StrategizeUpBook.com• Discover All Podcasts On The HubSpot Podcast Network#####Support The Podcast & Connect With Troy: • Rate & Review iDigress: iDigress.fm/Reviews• Follow Troy's LinkedIn @FindTroy• Need Growth Strategy, A Keynote Speaker, Or Want To Sponsor The Podcast? Go To FindTroy.com• Follow Troy's Instagram @FindTroy• Subscribe to Troy's YouTube Channel
In a world of endless noise, the brands that stand out are the ones that resonate, not the ones that shout.In this episode, we break down how resonance plays in marketing along with:• Resonance vs Volume in marketing.• Emotional connection > Simply Exposure.• The Psychology of Resonance: tapping into customer emotions, needs, and values.• Appealing to Emotions and Creating Memories (Limbic System) > Appealing to Logic (Neocortex)• LTV > One-Time Conversions.• How to create trust currency, brand loyalty, and community advocacy.• The importance of relationship-driven marketing and communication tactics.• How to apply this to social media, content, email, copy, and other media on various platforms. Beyond The Episode Gems:• Grow Your Business Faster Using HubSpot's CRM Platform• Use The Same Recording Platform I Use For My Podcast, Try Riverside.fm For Free• Buy Troy's Book, Strategize Up That Is Referenced In This Episode: StrategizeUpBook.com• Discover All Podcasts On The HubSpot Podcast Network#####Support The Podcast & Connect With Troy: • Rate & Review iDigress: iDigress.fm/Reviews• Follow Troy's LinkedIn @FindTroy• Get Strategy Solutions & Services: GrowWithTroy.com• Follow Troy's Instagram @FindTroy• Subscribe to Troy's YouTube Channel
Dans cet épisode du podcast "Sage-Femme Authentique," je reçois Anaïs et Ounia, deux jeunes sages-femmes fraîchement diplômées que j'ai eu le privilège d'accompagner en tant que promotrice externe. Ensemble, nous explorons un sujet aussi fascinant que crucial pour la pratique obstétricale et la préparation à l'accouchement: l'inhibition néocorticale.Anaïs et Ounia partagent leur parcours, depuis leurs premières aspirations jusqu'à la réalisation de leur travail de fin d'études, qui a impressionné les professeurs par sa profondeur et sa pertinence. Elles expliquent comment, en tant que sages-femmes, on peut favoriser l'inhibition du néocortex chez la femme en travail, un processus naturel essentiel pour permettre un accouchement physiologique et serein.L'inhibition néocorticale, c'est ce mécanisme par lequel le néocortex – la partie du cerveau responsable du langage, de la pensée analytique et du contrôle – se met en veille pour laisser place au cerveau archaïque, celui qui gouverne les processus instinctifs comme la naissance. Anaïs et Ounia décrivent comment, en tant que soignants, nous pouvons soutenir ce processus en créant un environnement propice à la déconnexion mentale et à la connexion avec l'instinct primaire.Nous abordons les outils pratiques que les sages-femmes peuvent utiliser pour accompagner les femmes dans cet état: de la vocalisation au massage, en passant par l'utilisation du peigne pour la pression, la chaleur de l'eau, la mastication, et plus encore. Ces techniques simples mais puissantes permettent de détourner l'attention de la douleur et d'améliorer le confort des futures mères, tout en respectant la physiologie de l'accouchement.Pour celles et ceux qui souhaitent en savoir plus sur ces pratiques, vous pouvez suivre Anaïs sur Instagram https://www.instagram.com/developpement_accompagnement/) où elle partage de précieuses informations sur l'accouchement physiologique et les outils pour une naissance sereine.Liste des Outils pour Aider à l'Inhibition NéocorticaleVocalisation: Utiliser la voix pour se connecter à son corps.Rire: Favoriser un état de détente et de bien-être.Respiration et Yoga: Techniques pour calmer l'esprit et relâcher les tensions.Relaxation de la Mâchoire: Favoriser l'ouverture du col de l'utérus.Massage: Soulager la douleur par la pression et le toucher.Eau Chaude: Relaxation par la chaleur.Peigne pour la Pression: Stimuler les points de pression pour détourner la douleur.Acupression et Réflexologie: Activer les points de pression pour soulager les contractions.Masturbation: Libérer des endorphines naturelles pour diminuer la perception de la douleur.Pénombre et Intimité: Créer un environnement sécurisant et rassurant.Liens vers les profils de médias sociaux- mail :melyssa@sagefemmeautetique.com- Instagram : https://www.instagram.com/sage_femme_authentique/?hl=fr- La Bulle Maison de Naissance :- Facebook : https://www.facebook.com/labulle.mdn- Instagram : https://www.instagram.com/labulle.mdn/?hl=fr- Site Web : www.la-bulle.beHébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.
Send us a Text Message.About the guest: Robert Barton, PhD is an evolutionary anthropologist and Professor at Durham University. He studies the evolution of the brain and behavior across species, including humans.Episode summary: Nick and Dr. Barton discuss: mammalian brain evolution; how brain and body size scale across mammals; how metabolism relates to brain size and function; the evolution of the neocortex & cerebellum in primates & humans; the concept of “intelligence” and whether it relates to brain size; and more.Related episodes:Evolution of Complex Behavior, Perception, Cognition, Consciousness & the Brain | Paul Cisek | #107Organisms, Cities, Companies & the Science of Scale | Geoffrey West | #12*This content is never meant to serve as medical advice.Support the Show.All episodes (audio & video), show notes, transcripts, and more at the M&M Substack Try Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase.Try SiPhox Health—Affordable, at-home bloodwork w/ a comprehensive set of key health marker. Use code TRIKOMES for a 10% discount.Try the Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off.Learn all the ways you can support my efforts
Explore the groundbreaking gut-brain axis with clinical Nutritionist Sarah Gilmour-Mayne. Uncover how Sarah uses applied kinesiology and quantum healing to unlock neuroplasticity for optimal patient wellness. This episode offers vital insights for healthcare professionals integrating psychoneuroimmunology and functional medicine into their practice. Episode Highlights:Mind-body integration: Neuroplasticity in clinical practiceQuantum biology and epigenetics in health optimisationMuscle testing for vagus nerve tone and HPA axis balanceNeurotransmitter balance and vagus nerve stimulation via gut microbiome Neocortex stimulation vs. limbic system regulation in healingMicrobiome modulation for cognitive function and emotional resilienceAbout Sarah: Sarah Gilmour-Mayne is a seasoned clinical nutritionist with over 20 years of experience in integrative medicine. Her expertise spans kinesiology, nutritional medicine, homeopathy, NLP coaching, and hypnosis. Sarah has developed a unique, bio-individual approach to empower clients to tap into their innate healing potential. As a respected educator, she has trained many of Australia's leading professional kinesiologists and continues teaching practitioners and individuals. Sarah's practice uniquely blends scientific foundations with metaphysical medicine, offering a holistic approach to wellness that bridges conventional and alternative therapies.Connect with Sarah: Website: Sarah Gilmour-Mayne Instagram: @sarah_gilmourmayneShownotes and references are available on your local Designs for Health websitewww.designsforhealth.com.auRegister as a Designs for Health Practitioner and discover quality practitioner-only supplements at www.designsforhealth.com.auFollow us on SocialsInstagram: DesignsforhealthausFacebook: DesignsforhealthausDISCLAIMER: The Information provided in the Wellness by Designs podcast is for educational purposes only; the information presented is not intended to be used as medical advice; please seek the advice of a qualified healthcare professional if what you have heard here today raises questions or concerns relating to your health
Nathan interviews Bernal Jimenez Gutierrez, creator of HippoRAG, a novel approach to retrieval augmented generation inspired by the human hippocampus. In this episode of The Cognitive Revolution, we explore how HippoRAG improves on traditional RAG systems, its neuroanatomical inspiration, and its potential for handling complex queries requiring multi-hop reasoning. Join us for an insightful discussion on the future of AI memory systems. Apply to join over 400 founders and execs in the Turpentine Network: https://hmplogxqz0y.typeform.com/to/JCkphVqj RECOMMENDED PODCAST: Complex Systems Patrick McKenzie (@patio11) talks to experts who understand the complicated but not unknowable systems we rely on. You might be surprised at how quickly Patrick and his guests can put you in the top 1% of understanding for stock trading, tech hiring, and more. Spotify: https://open.spotify.com/show/3Mos4VE3figVXleHDqfXOH Apple: https://podcasts.apple.com/us/podcast/complex-systems-with-patrick-mckenzie-patio11/id1753399812 SPONSORS: Oracle Cloud Infrastructure (OCI) is a single platform for your infrastructure, database, application development, and AI needs. OCI has four to eight times the bandwidth of other clouds; offers one consistent price, and nobody does data better than Oracle. If you want to do more and spend less, take a free test drive of OCI at https://oracle.com/cognitiveThe Brave search API can be used to assemble a data set to train your AI models and help with retrieval augmentation at the time of inference. All while remaining affordable with developer first pricing, integrating the Brave search API into your workflow translates to more ethical data sourcing and more human representative data sets. Try the Brave search API for free for up to 2000 queries per month at https://bit.ly/BraveTCR Omneky is an omnichannel creative generation platform that lets you launch hundreds of thousands of ad iterations that actually work customized across all platforms, with a click of a button. Omneky combines generative AI and real-time advertising data. Mention "Cog Rev" for 10% off https://www.omneky.com/ Head to Squad to access global engineering without the headache and at a fraction of the cost: head to https://choosesquad.com/ and mention “Turpentine” to skip the waitlist. CHAPTERS: (00:00:00) About the Show (00:02:52) Intro (00:05:10) RAG (00:09:29) Hippocampal Memory Indexing Theory (00:14:29) Neocortex, Parahippocampal Regions, Hippocampus (00:18:35) Hipporag (Part 1) (00:21:12) Sponsors: Oracle | Brave (00:23:20) Hipporag (Part 2) (00:23:29) Understanding the Hippocampus (00:29:37) RAG (00:31:38) Runtime (Part 1) (00:36:30) Sponsors: Omneky | Squad (00:38:17) Runtime (Part 2) (00:38:17) PageRank (00:39:29) Headline Results (00:43:22) Gaia Benchmark (00:46:33) Pathfinding vs Path Following (00:51:24) Future work (00:53:26) Starting with a query (00:58:30) Long context LLMs (01:01:50) Hybrid approach (01:05:03) AI Town (01:06:58) Flair (01:09:05) Getting it right, not cheap (01:12:33) Technologies to highlight (01:16:57) AI capabilities that are still unsolved (01:19:47) Transformers meet neural algorithmic reasoners (01:21:02) Closing (01:21:31) Outro
Aparna Bhaduri, Ph.D., shares insights into human brain development and its intricate processes. Explore the intriguing reappearance of developmental cell elements in brain cancers like glioblastoma. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38329]
Aparna Bhaduri, Ph.D., shares insights into human brain development and its intricate processes. Explore the intriguing reappearance of developmental cell elements in brain cancers like glioblastoma. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38329]
Aparna Bhaduri, Ph.D., shares insights into human brain development and its intricate processes. Explore the intriguing reappearance of developmental cell elements in brain cancers like glioblastoma. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38329]
Aparna Bhaduri, Ph.D., shares insights into human brain development and its intricate processes. Explore the intriguing reappearance of developmental cell elements in brain cancers like glioblastoma. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38329]
Aparna Bhaduri, Ph.D., shares insights into human brain development and its intricate processes. Explore the intriguing reappearance of developmental cell elements in brain cancers like glioblastoma. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38329]
Aparna Bhaduri, Ph.D., shares insights into human brain development and its intricate processes. Explore the intriguing reappearance of developmental cell elements in brain cancers like glioblastoma. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38329]
Aparna Bhaduri, Ph.D., shares insights into human brain development and its intricate processes. Explore the intriguing reappearance of developmental cell elements in brain cancers like glioblastoma. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38329]
Aparna Bhaduri, Ph.D., shares insights into human brain development and its intricate processes. Explore the intriguing reappearance of developmental cell elements in brain cancers like glioblastoma. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38329]
Aparna Bhaduri, Ph.D., shares insights into human brain development and its intricate processes. Explore the intriguing reappearance of developmental cell elements in brain cancers like glioblastoma. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38329]
NUESTRO CEREBRO - PARTE II En el directo de hoy profundizamos un poco más en esta herramienta maravillosa del SER HUMANO y hablamos del CEREBRO LIMBICO O EMOCIONAL así como del NEOCORTEX y de la CORTEZA PREFRONTAL Feliz vida
If the runaway success of tools like ChatGPT have taught us anything, it's that the world is ready to embrace AI. But are the policies and regulations ready to tackle the risks? Continuing our series on generative AI, this week host Elisa is joined by Matthew Ferraro, emerging technology expert and Counsel at Wilmer Hale. Matthew dives in, demystifying the terminology surrounding these tools while delving into the laws and notable cases that may shape the future of AI policy in the U.S. Matthew Ferraro is Counsel at Wilmer Hale: https://www.wilmerhale.com/en/people/matthew-ferraro References: S.1356, ASSESS AI Act: https://www.congress.gov/bill/118th-congress/senate-bill/1356/text S.1671, Digital Platform Commission Act of 2023: https://www.congress.gov/bill/118th-congress/senate-bill/1671/text?s=1&r=6 National Defense Authorization Act for 2021: https://www.congress.gov/bill/116th-congress/senate-bill/4049/text H.R.4521, America COMPETES Act: https://www.congress.gov/bill/117th-congress/house-bill/4521/text National Institute for Standards and Technology Artificial Intelligence Risk Management Framework: https://nvlpubs.nist.gov/nistpubs/ai/NIST.AI.100-1.pdf Young v. NeoCortex: https://dockets.justia.com/docket/california/cacdce/2:2023cv02496/880323 The Digital Millennium Copyright Act: https://www.copyright.gov/legislation/dmca.pdf Nominate National Security Law Today on People's Choice Podcast Awards through this link: https://www.podcastawards.com 1. Click the blue “Click Here to Vote” button 2. On the sign up site, check the box that says “Please consider me as one of the listeners that will be randomly selected to vote on the final slate in August” and enter “National Security Law Today” in the Biggest Podcast Influencer box 3. On the nomination site, nominate “National Security Law Today” for The Adam Curry People's Choice Award, Government & Organizations, and The Majority Report Politics & News Category
This interview took us for a spin through a myriad of worlds - from the rambunctious and chaotic Commedia dell'Arte performances of Renaissance Italy through the clown-like persona of Donald Trump to UFO mythologies! All of it viewed through the lens of the carnivalesque. Our guest Petter Madegård is a visual artist, a director of film and theatre and an actor. He is the inventor of the Commedia dell'Arte-inspired live animation theatre Cinema dell'Arte. Enjoy this interview filled with the uncontained power of spring. Excerpts from Petter Madegård's Cinema dell'Arte projects https://www.youtube.com/watch?v=ellxxrj-SY0 https://www.youtube.com/watch?v=xPzTMayjRNY https://www.youtube.com/watch?v=RAA_NXcAotU In the Borderlands www.intheborderlands.com REFERENCES Commedia dell'arte https://sv.wikipedia.org/wiki/Commedia_dell%27arte Jerzy Grotowski https://sv.wikipedia.org/wiki/Jerzy_Grotowski Rabelais and His World by Mikhail Bakhtin https://en.wikipedia.org/wiki/Rabelais_and_His_World Monty Python https://en.wikipedia.org/wiki/Monty_Python Mad https://en.wikipedia.org/wiki/Mad_(magazine) Rosetta Stone https://en.wikipedia.org/wiki/Rosetta_Stone Noh https://en.wikipedia.org/wiki/Noh Pantalone https://en.wikipedia.org/wiki/Pantalone The Merchant of Venice https://en.wikipedia.org/wiki/The_Merchant_of_Venice Assassin's Creed https://en.wikipedia.org/wiki/Assassin%27s_Creed Vecchio https://en.wikipedia.org/wiki/Vecchio Harlequin https://en.wikipedia.org/wiki/Harlequin Socker-Conny https://sv.wikipedia.org/wiki/Socker-Conny Hopi https://en.wikipedia.org/wiki/Hopi Motion Capture https://en.wikipedia.org/wiki/Motion_capture Avatar (film) https://en.wikipedia.org/wiki/Avatar_(2009_film) The Lord of the Rings https://en.wikipedia.org/wiki/The_Lord_of_the_Rings_(film_series) Andy Serkis https://en.wikipedia.org/wiki/Andy_Serkis Freedom of Information Act https://en.wikipedia.org/wiki/Freedom_of_Information_Act_(United_States) J. Allen Hynek https://en.wikipedia.org/wiki/J._Allen_Hynek John E. Mack https://en.wikipedia.org/wiki/John_E._Mack Grey alien https://en.wikipedia.org/wiki/Grey_alien Starseeds https://en.wikipedia.org/wiki/Star_people_(New_Age) Vodun https://en.wikipedia.org/wiki/West_African_Vodun David Icke https://en.wikipedia.org/wiki/David_Icke Reptilians https://en.wikipedia.org/wiki/Reptilian_conspiracy_theory Elf https://en.wikipedia.org/wiki/Elf Neocortex https://en.wikipedia.org/wiki/Neocortex
efJf Hawkins' 2021 book A Thousand Brains: A New Theory of Intelligence, focuses on the neocortex and how it helps us to understand the world around us, before examining the future of artificial intelligence, based on what we already know about the brain.In this final episode of Tales from the Synapse, a 12-part podcast series about neuroscience, Hawkins describes how his book finishes on a philosophical note, by covering the future of humanity in an age of intelligent machines.Hawkins is chief scientist at Numenta, a research company he started 17 years ago in Redwood City, California. He career started in the semiconductor industry but his interest in the theories underpinning brain science was triggered by a 1979 article in Scientific American, written by Francis Crick.“I realized that I don't think there's anything more interesting or important to work on, because every human endeavour is based on the brain. Everything we have ever done in the arts and the sciences, and literature and humanities and politics. It's all brains,” he says.Hawkins' search for an academic career in theoretical brain science proved fruitless, prompting a return to industry and the founding of both Palm Computing and Handspring. In 2002 he established the Redwood Neuroscience Institute, now based at the University of California Berkeley.Tales from the Synapse is produced in partnership with Nature Neuroscience and introduced by Jean Mary Zarate, a senior editor at the journal. The series features brain scientists from all over the world who talk about their career journeys, collaborations and the societal impact of their research. Hosted on Acast. See acast.com/privacy for more information.
Huberman Lab Key Takeaways Neuralink makes neural implants and delivers with a robotic insertion device that helps place tiny electrodes smaller than a human hair throughout a region of the brainNeuralink goals: Present – repair motor movement in people with spinal cord injury or paralysis using an external mouse and computer software to decode motor intentions (not connecting brain and motor movement just yet, for now, the focus is on establishing the agency in the movement of things in the world and eventually the body)Midterm – humans regaining control over some of the ways the brain goes wrong through addiction, depression, obesity, etc.Long-term – full expansion of human cognition into AI without limit, unrestricted communication (without phone), banding human minds togetherNeuroplasticity decreases with age but technology isn't necessarily the answer here because it involves altering the entire brain whereas machines are highly specialized and focusDon't worry about your Bluetooth headphones! It's unlikely there's enough energy to produce any harmAlcohol use is the most common source of brain damage many of us volunteer for – for every drink you have there is a linear increase in brain atrophy and neuron deathRead the full notes @ podcastnotes.orgIn this episode, my guest is Matthew MacDougall, MD, the head neurosurgeon at Neuralink. Dr. MacDougall trained at the University of California, San Diego and Stanford University School of Medicine and is a world expert in brain stimulation, repair and augmentation. He explains Neuralink's mission and projects to develop and use neural implant technologies and robotics to 1) restore normal movement to paralyzed patients and those with neurodegeneration-based movement disorders (e.g., Parkinson's, Huntington's Disease) and to repair malfunctions of deep brain circuitry (e.g., those involved in addiction). He also discusses Neuralink's efforts to create novel brain-machine interfaces (BMI) that enhance human learning, cognition and communication as a means to accelerate human progress. Dr. MacDougall also explains other uses of bio-integrated machines in daily life; for instance, he implanted himself with a radio chip into his hand that allows him to open specific doors, collect and store data and communicate with machines and other objects in unique ways. Listeners will learn about brain health and function through the lens of neurosurgery, neurotechnology, clinical medicine and Neuralink's bold and unique mission. Anyone interested in how the brain works and can be made to work better ought to derive value from this discussion. For the full show notes, visit hubermanlab.com. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman HVMN: https://hvmn.com/huberman Levels: https://levels.link/huberman Thesis: https://takethesis.com/huberman InsideTracker: https://insidetracker.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman Timestamps (00:00:00) Dr. Matthew MacDougall (00:04:05) Sponsors: HVMN, Levels, Thesis (00:07:38) Brain Function & Injury; Brain Tumor Treatment (00:13:52) Frontal Lobe Filter; Sleep Deprivation (00:19:00) Neuroplasticity, Pharmacology & Machines (00:22:10) Neuralink, Neural Implants & Injury, Robotics & Surgery (00:31:05) Sponsor: AG1 (Athletic Greens) (00:32:20) Neocortex vs. Deep Brain (00:36:45) Decoding Brain Signals (00:42:08) “Confidence Test” & Electrical Stimulation; RFID Implants (00:51:33) Bluetooth Headphones & Electromagnetic Fields; Heat (00:57:43) Brain Augmentation & Paralysis (01:00:51) Sponsor: InsideTracker (01:02:09) Brain Implants & Peripheral Devices (01:12:44) Brain Machine Interface (BMI), Neurofeedback; Video Games (01:22:13) Improving Animal Experimentation, Pigs (01:33:18) Skull & Injury, Traumatic Brain Injury (TBI) (01:39:14) Brain Health, Alcohol (01:43:34) Neuroplasticity, Brain Lesions & Redundancy (01:47:32) Car Accidents & Driver Alertness (01:50:00) Future Possibilities in Brain Augmentation & BMI; Neuralink (01:58:56) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Social Media, Neural Network Newsletter Title Card Photo Credit: Mike Blabac Disclaimer
In this episode, my guest is Matthew MacDougall, MD, the head neurosurgeon at Neuralink. Dr. MacDougall trained at the University of California, San Diego and Stanford University School of Medicine and is a world expert in brain stimulation, repair and augmentation. He explains Neuralink's mission and projects to develop and use neural implant technologies and robotics to 1) restore normal movement to paralyzed patients and those with neurodegeneration-based movement disorders (e.g., Parkinson's, Huntington's Disease) and to repair malfunctions of deep brain circuitry (e.g., those involved in addiction). He also discusses Neuralink's efforts to create novel brain-machine interfaces (BMI) that enhance human learning, cognition and communication as a means to accelerate human progress. Dr. MacDougall also explains other uses of bio-integrated machines in daily life; for instance, he implanted himself with a radio chip into his hand that allows him to open specific doors, collect and store data and communicate with machines and other objects in unique ways. Listeners will learn about brain health and function through the lens of neurosurgery, neurotechnology, clinical medicine and Neuralink's bold and unique mission. Anyone interested in how the brain works and can be made to work better ought to derive value from this discussion. For the full show notes, visit hubermanlab.com. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman HVMN: https://hvmn.com/huberman Levels: https://levels.link/huberman Thesis: https://takethesis.com/huberman InsideTracker: https://insidetracker.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman Timestamps (00:00:00) Dr. Matthew MacDougall (00:04:05) Sponsors: HVMN, Levels, Thesis (00:07:38) Brain Function & Injury; Brain Tumor Treatment (00:13:52) Frontal Lobe Filter; Sleep Deprivation (00:19:00) Neuroplasticity, Pharmacology & Machines (00:22:10) Neuralink, Neural Implants & Injury, Robotics & Surgery (00:31:05) Sponsor: AG1 (Athletic Greens) (00:32:20) Neocortex vs. Deep Brain (00:36:45) Decoding Brain Signals (00:42:08) “Confidence Test” & Electrical Stimulation; RFID Implants (00:51:33) Bluetooth Headphones & Electromagnetic Fields; Heat (00:57:43) Brain Augmentation & Paralysis (01:00:51) Sponsor: InsideTracker (01:02:09) Brain Implants & Peripheral Devices (01:12:44) Brain Machine Interface (BMI), Neurofeedback; Video Games (01:22:13) Improving Animal Experimentation, Pigs (01:33:18) Skull & Injury, Traumatic Brain Injury (TBI) (01:39:14) Brain Health, Alcohol (01:43:34) Neuroplasticity, Brain Lesions & Redundancy (01:47:32) Car Accidents & Driver Alertness (01:50:00) Future Possibilities in Brain Augmentation & BMI; Neuralink (01:58:56) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Social Media, Neural Network Newsletter Title Card Photo Credit: Mike Blabac Disclaimer
Today on the Mushroom Hour Podcast we are blessed to speak with Manoj Doss. Manoj is a cognitive neuropsychopharmacologist at the Center for Psychedelic and Consciousness Research at Johns Hopkins University. His research is at the intersection of cognitive neuroscience and neuropsychopharmacology with focuses on episodic memory and hallucinogenic drugs. Manoj utilizes complex cognitive paradigms, brain imaging, and computational modelling to explore what makes psychedelics unique compared to other classes of psychoactive drugs, both in terms of basic drug effects and mechanisms for treating clinical populations. Although Manoj is optimistic that psychedelics will soon have a place in psychiatry, he remains cautious of exaggerated claims and negligence to potential downsides, something he terms 'psychedelic myopia'. TOPICS COVERED: Cognitive Neuroscience & Neuropsychopharmacology Psychedelic Neuroscience Types of Memory - Episodic, Semantic, Procedural Parts of the Brain - Hippocampus, Neocortex Recollection vs Familiarity Psychedelics Impacting Memory through Familiarity Is Memory Stored in Parts of the Body Other than the Brain? How Do We Make False Memories? Debunking the “Default Mode Network” Narrative Psychedelic Science and Incorporating Existing Scientific Disciplines Showing Psychedelics are Actually Useful in Treating Any Disorders Commentary on Structuring Psychedelic Research Future of Psychedelic Therapy as Adjunct to Existing Therapies? Tempering Conclusions and Expectations from Psychedelic Research EPISODE RESOURCES: Manoj Doss Twitter: https://twitter.com/ManojDoss Manoj Doss Researchgate: https://www.researchgate.net/profile/Manoj-Doss Manoj Doss @ Johns Hopkins: https://hopkinspsychedelic.org/doss John O'Keefe Nobel Prize work on Hippocampal place cells: https://www.nature.com/articles/s41586-022-04913-9 Doss et al paper on reward dynamics: http://dml.ucdavis.edu/uploads/6/1/9/7/61974117/gruber_ritchey_wang_doss_ranganath_2016.pdf Default Mode Network Hypothesis: https://www.frontiersin.org/articles/10.3389/fnhum.2014.00020/full PiHKAL: A Chemical Love Story by Alexander Shulgin: https://www.amazon.com/Pihkal-Chemical-Story-Alexander-Shulgin/dp/0963009605 Janice Chen paper on shared experience: https://scholar.google.com/citations?view_op=view_citation&hl=en&user=mOwF8UEAAAAJ&citation_for_view=mOwF8UEAAAAJ:M05iB0D1s5AC Marc Berman paper on benefits of interacting with nature: https://journals.sagepub.com/doi/10.1111/j.1467-9280.2008.02225.x
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.03.535389v1?rss=1 Authors: Han, S., Helmchen, F. Abstract: Animals rely on predicting their environment and the consequences of their actions to adapt to a constantly changing world. The predictive coding hypothesis proposes that the brain generates predictions and continuously compares them with bottom-up sensory inputs to guide behavior. However, how the brain reconciles conflicting top-down predictions and bottom-up sensory information during behavior remains unclear. To address this question, we simultaneously imaged neuronal populations in the mouse somatosensory cortex and the posterior parietal cortex during an auditory-cued texture discrimination task. After mice learnt the task with fixed tone-texture matching, mismatched pairing caused conflicting tone-based texture predictions and actual texture inputs. When top-down interaction was dominant, texture representations in both areas were modified and mice decided based on the predicted rather than actual texture, whereas dominant bottom-up interaction corrected the representations as well as behavioral choice. Our findings provide evidence for hierarchical predictive coding in the mouse neocortex and open new avenues for understanding higher cognitive functions. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Today, Dr. Snyder is going to discuss how to control our Subconscious Mind. He will explore the different techniques in NLP that will allow you to control your subconscious mind and your emotions at will. Stay tuned. Standout Quotes: For every change you install, you've got to make it real. You got to act it out. You got to externalize it. For every psycho emotional state that you have, there is a corresponding breathing pattern and posture that goes with it. It's a feedback loop that leads into the other. Everything human beings do is a quest for state change. The problem that we have is that we try to regulate conscious mind stuff or unconscious mind and body stuff with our conscious mind, which is the first thing that's going to go the moment you have to exert control conscious willful control over an emotional experience. Key Takeaways: The most important filters in our neurology are the ones that allow us to move information from the inside of us to the outside of us whether it's in the form of writing, the form of speaking, any form of externalization allows us to solidify and make what we want more concreted at neurological level. We're taught in this culture that the mind controls the body. But in reality, the mind is the body and the body is the mind. So unless you go through very specialized training where you're in freezing cold water for hours on end, and you have to learn how to actually do calculus equations while in that water, the first thing that's going to happen when stress hits your body is your conscious mind is going to shut off and you're going to default to whatever's there that nature put in there. The environment can overwhelm you. The people in the environment can overwhelm you. Everything has the capacity to overwhelm you, especially emotions whether it is positive or negative. Episode Timeline: [01:37] Welcome to NLP/Power [04:42] The NeoCortex Brain [07:39] The Job of the NeoCortex [13:14] Disidentifying with Neurology [16:58] The Fastest and Most Reliable way to Change Anyone in 2 Minutes [25:25] Power Poses [28:22] Importance of Balance in Chinese Medicine [31:31] State Control 101 [34:38] Smart Person Syndrome [39:54] The Spinning Method [48:54] Conveyancer Strategy [53:40] What you need to Understand about NLP
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Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.01.09.523297v1?rss=1 Authors: Whitman, E. T., Knodt, A. R., Elliott, M. L., Abraham, W. C., Cheyne, K., Hogan, S., Ireland, D., Keenan, R., Lueng, J. H., Melzer, T. R., Poulton, R., Purdy, S. C., Ramrakha, S., Thorne, P. R., Caspi, A., Moffitt, T. E., Hariri, A. R. Abstract: Although higher-order cognitive and lower-order sensorimotor abilities are generally regarded as distinct and studied separately, there is evidence that they not only covary but also that this covariation increases across the lifespan. This pattern has been leveraged in clinical settings where a simple assessment of sensory or motor ability (e.g., hearing, gait speed) can forecast age-related cognitive decline and risk for dementia. However, the brain mechanisms underlying cognitive, sensory, and motor covariation are largely unknown. Here, we examined whether such covariation in midlife reflects variability in common versus distinct neocortical networks using individualized maps of functional topography derived from BOLD fMRI data collected in 769 45-year old members of a population-representative cohort. Analyses revealed that variability in basic motor but not hearing ability reflected individual differences in the functional topography of neocortical networks typically supporting cognitive ability. These patterns suggest that covariation in motor and cognitive abilities in midlife reflects convergence of function in higher-order neocortical networks and that gait speed may not be simply a measure of physical function but rather an integrative index of nervous system health. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.12.30.522267v1?rss=1 Authors: Rao, R. P. N. Abstract: We propose that the neocortex implements active predictive coding (APC), a form of predictive coding that incorporates hierarchical dynamics and actions. In this model, each neocortical area estimates both sensory states and actions, and the cortex as whole learns to predict the sensory consequences of actions at multiple hierarchical levels. ''Higher'' cortical areas maintain more abstract representations at larger spatiotemporal scales compared to ''lower'' areas. Feedback from higher areas modulate the dynamics of both state and action networks in lower areas. This allows the cortical network to model the complex dynamics and physics of the world in terms of simpler compositional elements (state transition functions). Simultaneously, current higher level goals invoke sequences of lower level sub-goals and actions, allowing the network to solve complex planning problems by composing simpler solutions. Planning ("system 2" thinking) in turns allows the network to learn, over time, perception-to-action mappings (policies; "system 1" thinking) at multiple abstraction levels. We provide examples from simulations illustrating how the same APC architecture can solve problems that, at first blush, seem very different from each other: (1) how do we recognize an object and its parts using eye movements? (2) why does perception seem stable despite eye movements? (3) how do we learn compositional representations, e.g., part-whole hierarchies, and nested reference frames for equivariant vision? (4) how do we model the "physics" of a complex environment by decomposing it into simpler components? (5) how do we plan actions in a complex domain to achieve a goal by composing sequences of sub-goals and simpler actions? and (6) how do we form episodic memories of sensory-motor experiences? We propose a mapping of the APC network to the laminar architecture of the cortex and suggest possible roles for cortico-cortical, cortico-thalamic, cortico-hippocampal and cortico-subcortical pathways. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Unsere Neuroplastizität schenkt uns die Fähigkeit zur stetigen Veränderung. Wenn uns Veränderung schwer fällt, wenn wir schon ganz viel ausprobiert haben, uns aber nachhaltige Veränderung nicht wirklich gelingt, dann kann es sehr gut möglich sein, dass in unserer Neurobiologie, in unserem Stammhirn unerlöstes Trauma sitzt. Unser Gehirn ist in unterschiedlichen Gehirnteilen unterteilt. Unser vorderes Hirn, der sogenannte Neocortex ist in aktivierter Form dafür zuständig Empathie, Wachstum, Veränderung, Reflektion, Flexibilität, feinfühlige Interaktion, Perspektivenwechsel zu leben. Wenn allerdings unverarbeitete Traumaenergie in unserer Neurobiologie herrscht, dann ist unser Stammhirn und unser lymbischer Gehirnteil (welcher im Übrigen Routine und Gewohnheit liebt) aktiviert und unser vorderer Gehirnteil sozusagen ausgeschaltet, so dass Veränderung kaum oder gar nicht wirklich möglich ist. In dieser Folge mag ich dir ganz einfach und verständlich erklären, warum es so wichtig ist, dass wir uns traumasensible begleiten lassen dürfen, wenn wir tiefe nachhaltige Veränderung in unserem Leben erzielen wollen und ein zutiefst verbundenes, leichtes und erfülltes Leben damit erreichen. Ich wünsche Dir viel Freude beim Lauschen. Alles Liebe Ella Catau - Dein Coach für Selbstverwirklichung und Selbstfindung
In this conversation, Daniel Belkin and Mitch Belkin interview Jean Hébert, PhD about aging, brain plasticity, and progressive neocortical replacement. They discuss one hallmark of aging—extracellular matrix damage—as well as how tissue replacement is a possible solution to aging. In addition, they explore the practicalities of progressive neocortex replacement, dopaminergic neuron transplants in Parkinson's patients, and Professor Hébert's work on stroke.Who is Jean Hébert?Jean Hebert, PhD, is a Professor of Neuroscience and Genetics at the Albert Einstein College of Medicine where he focuses on age-related brain degeneration in the adult neocortex. He is one of the world's leading researchers on brain cell and tissue replacement. He is the author of the book Replacing Aging.Follow us at @ExMedPod Subscribe to our Youtube channelConsider supporting us on Patreon
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.11.08.515739v1?rss=1 Authors: Lee, B., Dalley, R., Miller, J. A., Chartrand, T., Close, J., Mann, R., Mukora, A., Ng, L., Alfiler, L., Baker, K., Bertagnolli, D., Brouner, K., Casper, T., Csajbok, E., Dee, N., Donadio, N., Driessens, S. L. W., Egdorf, T., Enstrom, R., Galakhova, A. A., Gary, A., Gelfand, E., Goldy, J., Hadley, K., Heistek, T. S., Hill, D., Johansen, N., Jorstad, N., Kim, L., Kocsis, A. K., Kruse, L., Kunst, M., Leon, G., Long, B., Mallory, M., Maxwell, M., McGraw, M., McMillen, D., Melief, E. J., Molnar, G., Mortrud, M. T., Newman, D., Nyhus, J., Opitz-Araya, X., Pham, T., Pom, A., Potekhina, L., Rajanbabu Abstract: Human cortical interneurons have been challenging to study due to high diversity and lack of mature brain tissue platforms and genetic targeting tools. We employed rapid GABAergic neuron viral labeling plus unbiased Patch-seq sampling in brain slices to define the signature morpho-electric properties of GABAergic neurons in the human neocortex. Viral targeting greatly facilitated sampling of the SST subclass, including primate specialized double bouquet cells which mapped to two SST transcriptomic types. Multimodal analysis uncovered an SST neuron type with properties inconsistent with original subclass assignment; we instead propose reclassification into PVALB subclass. Our findings provide novel insights about functional properties of human cortical GABAergic neuron subclasses and types and highlight the essential role of multimodal annotation for refinement of emerging transcriptomic cell type taxonomies. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.11.06.515349v1?rss=1 Authors: Jorstad, N. L., Close, J., Johansen, N., Yanny, A. M., Barkan, E. R., Travaglini, K. J., Bertagnolli, D., Campos, J., Casper, T., Crichton, K., Dee, N., Ding, S.-L., Gelfand, E., Goldy, J., Hirschstein, D., Kroll, M., Kunst, M., Lathia, K., Long, B., Martin, N., McMillen, D., Pham, T., Rimorin, C., Ruiz, A., Shapovalova, N., Shehata, S., Siletti, K., Somasundaram, S., Sulc, J., Tieu, M., Torkelson, A., Tung, H., Ward, K., Callaway, E. M., Hof, P. R., Keene, C. D., Levi, B. P., Linnarsson, S., Mitra, P. P., Smith, K., Hodge, R. D., Bakken, T. E., Lein, E. S. Abstract: Variation in cortical cytoarchitecture is the basis for histology-based definition of cortical areas, such as Brodmann areas. Single cell transcriptomics enables higher-resolution characterization of cell types in human cortex, which we used to revisit the idea of the canonical cortical microcircuit and to understand functional areal specialization. Deeply sampled single nucleus RNA-sequencing of eight cortical areas spanning cortical structural variation showed highly consistent cellular makeup for 24 coarse cell subclasses. However, proportions of excitatory neuron subclasses varied strikingly, reflecting differences in intra- and extracortical connectivity across primary sensorimotor and association cortices. Astrocytes and oligodendrocytes also showed differences in laminar organization across areas. Primary visual cortex showed dramatically different organization, including major differences in the ratios of excitatory to inhibitory neurons, expansion of layer 4 excitatory neuron types and specialized inhibitory neurons. Finally, gene expression variation in conserved neuron subclasses predicts differences in synaptic function across areas. Together these results provide a refined cellular and molecular characterization of human cortical cytoarchitecture that reflects functional connectivity and predicts areal specialization. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
We often hear that we're remarkably similar to our primate relatives, both in terms of our genetics and our behaviour. We're social beings. We use tools. But only humans have come to dominate the planet - why? Could the answer lie in the small differences between the human brain and that of other primates? In this episode of the Oxford Sparks Big Questions Podcast, we talk to neuroscientist Dr Rogier Mars about what makes the human brain so special. Please note that Dr Rogier Mars and his team work on the brains of non-human primates that have died of natural causes, and have subsequently been donated for research purposes.
Why did the two hemispheres of our brain evolve to have such different perspectives - such divergent ways of attending to our world? In this episode we explore evidence that the evolution of the human brain has evolved along three axis: Bottom-to-Top; Side-to-Side; and Back-to-Front. Each evolutionary development enhanced the capacity and complexity of a different part of the human brain and exaggerated the divergent roles of the two hemispheres.
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.10.27.514048v1?rss=1 Authors: Dobolyi, A., Bago, A. G., Stepanova, A., Paal, K., Lee, J., Palkovits, M., Chinopoulos, C. Abstract: The astrocyte-to-neuron lactate shuttle hypothesis entails that glycolytically derived pyruvate in astrocytes is converted to lactate instead of being catabolized in mitochondria. The mechanism of this metabolic rewiring is unclear. Here we show that astrocytes of the adult human neocortex and hippocampal formation do not express mitochondrial proteins critical for performing oxidative phosphorylation (OXPHOS) to a detectable degree, including cytochrome c and complex IV. Without OXPHOS, human brain astrocytes are bound to produce lactate to avoid interruption of glycolysis. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.10.24.511199v1?rss=1 Authors: Chartrand, T., Dalley, R., Close, J., Goriounova, N. A., Lee, B. R., Mann, R., Miller, J. A., Molnar, G., Mukora, A., Alfiler, L., Baker, K., Bakken, T. E., Berg, J., Bertagnolli, D., Braun, T., Brouner, K., Casper, T., Csajbok, E. A., Dee, N., Egdorf, T., Enstrom, R., Galakhova, A. A., Gary, A., Gelfand, E., Goldy, J., Hadley, K., Heistek, T. S., Hill, D., Jorstad, N., Kim, L., Kocsis, A. K., Kruse, L., Leon, G., Long, B., Mallory, M., McGraw, M., McMillen, D., Melief, E. J., Mihut, N., Ng, L., Nyhus, J., Omstead, V., Peterfi, Z., Pom, A., Potekhina, L., Rajanbabu, R., Rozsa, M., Ruiz, A., Sa Abstract: Neocortical layer 1 (L1) is a site of convergence between pyramidal neuron dendrites and feedback axons where local inhibitory signaling can profoundly shape cortical processing. Evolutionary expansion of human neocortex is marked by distinctive pyramidal neuron types with extensive branching in L1, but whether L1 interneurons are similarly diverse is underexplored. Using patch-seq recordings from human neurosurgically resected tissues, we identified four transcriptomically defined subclasses, unique subtypes within those subclasses and additional types with no mouse L1 homologue. Compared with mouse, human subclasses were more strongly distinct from each other across all modalities. Accompanied by higher neuron density and more variable cell sizes compared with mouse, these findings suggest L1 is an evolutionary hotspot, reflecting the increasing demands of regulating the expanding human neocortical circuit. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Wir wollen ja nicht alarmistisch klingen, aber unsere Alarmglocken sind schon wieder rot geworden. ALARM! Spätestens als mal wieder "Meinungen" bei Lanz diskutiert wurden, aber hey, das ist gut gegen niedrigen Blutdruck. Solange Elon Musk uns noch nicht TikTok kauft und überlässt, überlassen wir uns stattdessen der "Arbeitsgruppe konstruktiv". Auf geht's, paar Stimmübungen und dann lasst gern eure Emotionen sprechen – nur nicht beim Streiten! Sonst kommt Loki vorbei, zwingt euch in die Knie und fordert die Kehrwoch! Seine Negativität ist negativ. Sorry, aber das ist einfach unsere Meinung. Findet in dieser Folge heraus, was eine Meinung überhaupt ist, und warum wir kein Recht darauf haben. Stoßt mit uns am digitalen Stammtisch auf die Satisfaktionsfähigkeit an und sagt Günter Bescheid, dass er uns keine Morddrohungen schicken soll. Aber bleibt dabei entspannt, sonst kackt euer Neocortex ab. Dann müssen wir alle die 15-Uhr-Meditationsstunde auf Twitter einführen. Und schließlich eine ernstgemeinte Frage an alle: Welche Meinung habt ihr zuletzt aus guten Gründen geändert? Du möchtest mehr über unsere Werbepartner erfahren? Hier findest du alle Infos und Rabatte: https://linktr.ee/CoupleOf
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.09.27.509690v1?rss=1 Authors: Kwon, S. E., Zhao, M. Abstract: SYNGAP1 haploinsufficiency in humans results in severe neurodevelopmental disorders characterized by intellectual disability, autism, epilepsy, and sensory processing deficits. However, circuit mechanisms that underlie SYNGAP1-related neurodevelopmental disorders are poorly understood. A decrease of SynGAP in mice causes cognitive and behavioral deficits in part by disrupting the development of excitatory glutamatergic connections. Whether and to what extent SynGAP functions in inhibitory circuits remain unclear. We show that interneuron-specific SYNGAP1 heterozygous mice display learning deficits characterized by elevated behavioral responses in the absence of relevant sensory input and premature responses to a sensory input unrelated to reward acquisition. These behavioral deficits are associated with specific circuit abnormalities within primary somatosensory cortex, characterized by increased detrimental correlations and elevated responses to irrelevant sensory stimuli. Collectively, we show that a decrease of SynGAP in inhibitory interneurons disrupts sensory representation in the primary sensory cortex, which likely contributes to behavioral deficits. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer
Jason Lowery from the US Space Force, joins me for a conversation about Ethereum's Merge, how proof of stake disconnects Ethereum from reality, and why proof of work is the technological breakthrough necessary for changing the power structures in our evolutionary process.Be sure to check out Swan Private, the trusted Bitcoin financial services provider for high-net-worth individuals and businesses worldwide: https://www.swanprivate.com/breedloveGuestJason Lowery's Twitter Account: https://twitter.com/JasonPLoweryPODCASTPodcast Website: https://whatismoneypodcast.com/Apple Podcast: https://podcasts.apple.com/us/podcast/the-what-is-money-show/id1541404400 Spotify: https://open.spotify.com/show/25LPvm8EewBGyfQQ1abIsE?si=wgVuY16XR0io4NLNo0A11A&nd=1RSS Feed: https://feeds.simplecast.com/MLdpYXYITranscript:Outline00:00:00 “What is Money” Intro00:00:08 Learn about Bitcoin with Swan Private at SwanPrivate.Com00:01:37 Vitalik's Comments: “Proof of Stake... Has Its Own Laws of Physics”00:08:52 The Lack of Reality in Proof of Stake00:19:59 The Neocortex of the Brain: Thinking Abstractly and the Ability to Plan For Your Future Self00:44:19 Technological Breakthroughs Lead to a Step Function Change Within Our Evolutionary Process00:48:55 Prisoners of Symbolism01:00:54 Power Projection Leads to a Natural Hierarchy System01:09:50 Imaginary Symbolic Structures: The Human Ability to Transpose Reality Through Storytelling and the Imagination01:25:18 Watch “Hard Money with Natalie Brunell” From Swan Studios01:25:59 Take Control of Your Healthcare with Crowd Health01:26:58 “Predator Detection Matrix”01:39:51 Virtual Reality, Cyberspace and the Collective Imagination01:53:02 “God Kings” - How Abstract Forms of Power Hierarchy Lead to Corruption and Warfare02:08:05 “Power Is The Proof”02:16:07 Post Merge Ethereum: How Proof of Stake Disconnects Ethereum from Reality02:24:30 Energy Usage and Power Projection Leads to Better Security and Human Flourishing02:38:57 “What is Money” OutroSOCIALBreedlove Twitter: https://twitter.com/Breedlove22WiM? Twitter: https://twitter.com/WhatisMoneyShowLinkedIn: https://www.linkedin.com/in/breedlove22/Instagram: https://www.instagram.com/breedlove_22/TikTok: https://www.tiktok.com/@breedlove22?lang=enAll My Current Work: https://linktr.ee/breedlove22 WRITTEN WORKMedium: https://breedlove22.medium.com/Substack: https://breedlove22.substack.com/ WAYS TO CONTRIBUTEBitcoin: 3D1gfxKZKMtfWaD1bkwiR6JsDzu6e9bZQ7Sats via Strike: https://strike.me/breedlove22Sats via Tippin.me: https://tippin.me/@Breedlove22Dollars via Paypal: https://www.paypal.com/paypalme/RBreedloveDollars via Venmo: https://venmo.com/code?user_id=1784359925317632528The "What is Money?" Show Patreon Page: https://www.patreon.com/user?u=32843101&fan_landing=true RECOMMENDED BUSINESSESSwan Private guides high-net-worth individuals and businesses in all areas of Bitcoin strategy: https://www.swanprivate.com/breedloveCrowdHealth offers an innovative health insurance model based on Bitcoin and community: https://www.joincrowdhealth.com/breedloveOkcoin is an innovative and education-focused cryptoasset exchange platform—earn $50 in free Bitcoin by signing up at: https://okcoin.com/breedloveInvest with a licensed Bitcoin advisor through DAIM: https://daimio.typeform.com/RobertBreedloveJoin Me At Bitcoin 2023, pre-order your tickets now (for a chance to win 10M sats, use discount code BREEDLOVE): https://b.tc/conference/2023Automatic Recurring Bitcoin Buys and Withdrawals: https://www.swanbitcoin.com/breedlove/
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.09.13.507776v1?rss=1 Authors: Assendorp, N. M., Depp, M., Fossati, M., Dingli, F., Loew, D., Charrier, C. Abstract: Human-specific genes are potential drivers of brain evolution. Among them, SRGAP2C contributes to distinct features by extending the period of synaptic maturation and increasing cortical connectivity. Here we examined SRGAP2 protein-interaction network in developing synapses and identified catenin delta-2 (CTNND2) as a binding partner of human-specific SRGAP2C. CTNND2 is a cadherin-binding protein implicated in intellectual disability in the Cri-du-Chat syndrome, severe autism and epilepsy. Using sparse manipulations in upper layer cortical pyramidal neurons, we demonstrate that CTNND2 is an activity-limiting protein that coordinates synaptic excitation and inhibition and controls intrinsic excitability in juvenile mice. Later in adults, CTNND2 is required for long-term maintenance of dendritic spines. CTNND2 enrichment at excitatory synapses is enhanced by human-specific SRGAP2C. Thus, while loss of CTNND2 function accelerates synaptic development, causes overexcitation and homeostatic failure, its upregulation by SRGAP2C may contribute to synaptic neoteny in humans and protect against precocious synapse loss during aging. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer
In this episode of Intel on AI host Amir Khosrowshahi talks with Jeff Lichtman about the evolution of technology and mammalian brains. Jeff Lichtman is the Jeremy R. Knowles Professor of Molecular and Cellular Biology at Harvard. He received an AB from Bowdoin and an M.D. and Ph.D. from Washington University, where he worked for thirty years before moving to Cambridge. He is now a member of Harvard's Center for Brain Science and director of the Lichtman Lab, which focuses on connectomics— mapping neural connections and understanding their development. In the podcast episode Jeff talks about why researching the physical structure of brain is so important to advancing science. He goes into detail about Brainbrow—a method he and Joshua Sanes developed to illuminate and trace the “wires” (axons and dendrites) connecting neurons to each other. Amir and Jeff discuss how the academic rivalry between Santiago Ramón y Cajal and Camillo Golgi pioneered neuroscience research. Jeff describes his remarkable research taking nanometer slices of brain tissue, creating high-resolution images, and then digitally reconstructing the cells and synapses to get a more complete picture of the brain. The episode closes with Jeff and Amir discussing theories about how the human brain learns and what technologists might discover from the grand challenge of mapping the entire nervous system. Academic research discussed in the podcast episode: Principles of Neural Development The reorganization of synaptic connexions in the rat submandibular ganglion during post-natal development Development of the neuromuscular junction: Genetic analysis in mice A technicolour approach to the connectome The big data challenges of connectomics Imaging Intracellular Fluorescent Proteins at Nanometer Resolution Stimulated emission depletion (STED) nanoscopy of a fluorescent protein-labeled organelle inside a living cell High-resolution, high-throughput imaging with a multibeam scanning electron microscope Saturated Reconstruction of a Volume of Neocortex A connectomic study of a petascale fragment of human cerebral cortex A Canonical Microcircuit for Neocortex
The most difficult, and most important, work you'll ever do is your EMOTIONAL work. Intellectual work is important; and yet the Neocortex more often than not gets you stuck in the paralysis of analysis. Information is NOT Transformation; and not even close to transmutation. Your thinking mind is both a blessing and a curse. Because your head will mess you up every single time…
In this episode the Augment hosts are joined by AAHKS Publications Committee Vice Chair Christopher E. Pelt, MD, who discusses two of his recently published articles, “Extended oral antibiotics increase bacterial resistance in patients who fail 2-stage exchange for periprosthetic joint infection” and “Neocortex formation in a tapered wedge stem is not indicative of complications […] The post The YAG Augment: Infection Article Roundup (Season 2, Episode 10) first appeared on AAHKS.
In this episode, Lexman welcomes Steven Pinker, one of the world's leading thinkers on human cognition and language. Pinker discusses the neocortex, which is responsible for everything from making complex choices to solving problems. He also discusses deambulatory heliographs, which are a form of communication used by argyle monkeys in the forests of Brazil. Finally, he talks about mon, the language of the modern world.
I know, we don't have much time to cram everything in our lessons but some things are worth taking time over: checking your students' understanding of vocabulary and instructions. I mean, how hard is it? Not that hard, actually but I'm sure I'm not the only one who's guilty of neglecting a few concept-checking and instruction-checking questions from time to time......not sure what I'm on about? This episode is for you. Been teaching a long time? Sure, dive in and refresh your memory. I guarantee the last time you really looked at CCQs and ICQs in detail was your teaching course, was it not...? Useful links: https://www.teachingenglish.org.uk/article/checking-understanding https://en.wikipedia.org/wiki/Neocortex#:~:text=The%20neocortex%2C%20also%20called%20the,commands%2C%20spatial%20reasoning%20and%20language. https://human-memory.net/neocortex/ https://englishhelponline.me/2010/05/18/grammatical-expression-manage-to-do-something/ https://human-memory.net/neocortex/ Sign up to my twice-monthly newsletter for more teachy stuff: https://landing.mailerlite.com/webforms/landing/l5f8v6 Theme music by @sean.cass (Instagram). Like, share, DM me and follow me on Instagram @https://www.instagram.com/everythingeflteacher/ and on Facebook @https://www.facebook.com/groups/everythingeflteacherdevelopment Subscribe to Youtube @Everything EFL for teaching tip videos and full podcast episodes with Closed Captions. Email me at showandtelleverythingefl@gmail.com. Connect with me on LinkedIn @ https://www.linkedin.com/in/erin-o-byrne-90b58a55/ Subscribe to the podcast on Spotify, Google Podcasts, Apple.... and don't forget to tell your colleagues. Share the love. --- Send in a voice message: https://anchor.fm/everything-efl/message
Welcome to The Nonlinear Library, where we use Text-to-Speech software to convert the best writing from the Rationalist and EA communities into audio. This is: My computational framework for the brain , published by Steven Byrnes on the AI Alignment Forum. Crossposted from the AI Alignment Forum. May contain more technical jargon than usual. By now I've written a bunch of blog posts on brain architecture and algorithms, not in any particular order and generally interspersed with long digressions into Artificial General Intelligence. Here I want to summarize my key ideas in one place, to create a slightly better entry point, and something I can refer back to in certain future posts that I'm planning. If you've read every single one of my previous posts (hi mom!), there's not much new here. In this post, I'm trying to paint a picture. I'm not really trying to justify it, let alone prove it. The justification ultimately has to be: All the pieces are biologically, computationally, and evolutionarily plausible, and the pieces work together to explain absolutely everything known about human psychology and neuroscience. (I believe it! Try me!) Needless to say, I could be wrong in both the big picture and the details (or missing big things). If so, writing this out will hopefully make my wrongness easier to discover! Pretty much everything I say here and its opposite can be found in the cognitive neuroscience literature. (It's a controversial field!) I make no pretense to originality (with one exception noted below), but can't be bothered to put in actual references. My previous posts have a bit more background, or just ask me if you're interested. :-P So let's start in on the 7 guiding principles for how I think about the brain: 1. Two subsystems: "Neocortex" and "Subcortex" This is the starting point. I think it's absolutely critical. The brain consists of two subsystems. The neocortex is the home of "human intelligence" as we would recognize it—our beliefs, goals, ability to plan and learn and understand, every aspect of our conscious awareness, etc. etc. (All mammals have a neocortex; birds and lizards have an homologous and functionally-equivalent structure called the "pallium".) Some other parts of the brain (hippocampus, parts of the thalamus & basal ganglia & cerebellum—see further discussion here) help the neocortex do its calculations, and I lump them into the "neocortex subsystem". I'll use the term subcortex for the rest of the brain (brainstem, hypothalamus, etc.). Aside: Is this the triune brain theory? No. Triune brain theory is, from what I gather, a collection of ideas about brain evolution and function, most of which are wrong. One aspect of triune brain theory is putting a lot of emphasis on the distinction between neocortical calculations and subcortical calculations. I like that part. I'm keeping that part, and I'm improving it by expanding the neocortex club to also include the thalamus, hippocampus, lizard pallium, etc., and then I'm ignoring everything else about triune brain theory. 2. Cortical uniformity I claim that the neocortex is, to a first approximation, architecturally uniform, i.e. all parts of it are running the same generic learning algorithm in a massively-parallelized way. The two caveats to cortical uniformity (spelled out in more detail at that link) are: There are sorta "hyperparameters" on the generic learning algorithm which are set differently in different parts of the neocortex—for example, different regions have different densities of each neuron type, different thresholds for making new connections (which also depend on age), etc. This is not at all surprising; all learning algorithms inevitably have tradeoffs whose optimal settings depend on the domain that they're learning (no free lunch). As one of many examples of how even "generic" learning algorithms benefit from domain-specific hyperparameters, if you've seen a pattern "A then B then C" recur 10 times in a row, you will start un...
Tomar una decisión puede ser complicada o a veces arrebatada, por ello es fundamental saber sobre el Cerebro Triuno. Por ello quiero hablarles sobre las tres partes del cerebros que tenemos y que toman las decisiones de nuestra vida. Si te interesa como funciona nuestro cerebro: reptil, límbico y Neocortex. Te invito a que escuches y aprendas más de como podemos tomar las mejores decisiones en tu vida. Y recuerda seguirme para conocer más del tema.