Podcasts about Alteration

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Best podcasts about Alteration

Latest podcast episodes about Alteration

Astrology Alchemy Podcast
#346-“You Stop Trying to Make Sense of Things”-- Week of January 5, 2026

Astrology Alchemy Podcast

Play Episode Listen Later Jan 4, 2026 11:43 Transcription Available


This week concentrates powerful Capricorn energy, activating themes of commitment, responsibility, desire, and relational truth—all tested through tension with Jupiter in Cancer and Chiron in Aries. The question underneath it all: What are you truly willing to tend, protect, and build?Tuesday, Jan 6 — Venus conjunct Sun in CapricornArchetypal Dialogue: The Lover meets the Sovereign A renewal of values and relational orientation. What you love seeks alignment with what you are responsible for. Beauty, worth, and devotion ask to be taken seriously.Reflection Question: Where am I clarifying what truly matters—and what I'm willing to commit to?Wednesday, Jan 7 — Venus conjunct Mars in CapricornArchetypal Dialogue: Desire joins Discipline Attraction meets will. Passion becomes purposeful when guided by integrity and long-term vision. This is a moment to act in alignment with your values.Reflection Question: How can my desire move with maturity rather than impulse?Friday, Jan 9 — Sun conjunct Venus in Capricorn and Venus in Capricorn opposes Jupiter in CancerArchetypal Dialogue: Devotion faces Expansion A peak moment for relationship and value themes. The tension asks you to balance duty with emotional nourishment—ambition with care.Reflection Question: Where might growth require both boundaries and tenderness?Saturday, Jan 10 — Sun & Mars in Capricorn oppose Jupiter in CancerArchetypal Dialogue: Authority meets Protection Drive and responsibility meet the need for safety and belonging. Overreach or defensiveness may surface if inner needs are ignored.Reflection Question: Am I acting from grounded authority—or compensating for unmet emotional needs?Sunday, Jan 11 — Venus in Capricorn square Chiron in AriesArchetypal Dialogue: The Lover meets the Wounded Self Old relational wounds or identity sensitivities may be activated. This is an invitation to mature self-worth through compassion rather than self-judgment.Reflection Question: What would honoring my worth look like without needing to prove myself?Podcast poem: Alteration by Rosemerry Wahtola TrommerSupport the showGo to Sheila's website for information for transformational resources: https://www.ontheedgesofchange.com/home-page This episode was co-created with generative AI, engaged as a soul-aligned ally in service of transformation. At the edge where technology meets myth, I choose insight over noise, and alchemy over automation. Thank you for dreaming the future with me.

JCO Precision Oncology Conversations
Podcast: FGFR3 Alteration Status and Immunotherapy in Urothelial Cancer

JCO Precision Oncology Conversations

Play Episode Listen Later Dec 17, 2025 18:51


JCO PO author Dr. Shilpa Gupta at Cleveland Clinic Children's Hospital shares insights into her article, "Fibroblast Growth Factor Receptor 3 (FGFR3) Alteration Status and Outcomes on Immune Checkpoint Inhibitors (ICPI) in Patients with Metastatic Urothelial Carcinoma". Host Dr. Rafeh Naqash and Dr. Gupta discuss how FGFR3 combined with TMB emerged as a biomarker that may be predictive for response to ICPI in mUC. TRANSCRIPT Dr. Rafeh Naqash: Hello and welcome to JCO Precision Oncology Conversations, where we bring you engaging conversations with authors of clinically relevant and highly significant JCO PO articles. I'm your host, Dr. Rafeh Naqash, podcast editor for JCO Precision Oncology and Associate Professor at the OU Health Stephenson Cancer Center. Today I am excited to be joined by Dr. Shilpa Gupta, Director of Genitourinary Medical Oncology at the Cancer Institute and co-leader of the GU Oncology Program at the Cleveland Clinic, and also lead author of the JCO PO article titled "Fibroblast Growth Factor Receptor 3 Alteration Status and Outcomes on Immune Checkpoint Inhibitors in Patients With Metastatic Urothelial Carcinoma." At the time of this recording, our guest's disclosures will be linked in the transcript. Shilpa, welcome again to the podcast. Thank you for joining us today. Dr. Shilpa Gupta: Thank you, Rafeh. Honor to be here with you again. Dr. Rafeh Naqash: It is nice to connect with you again after two years, approximately. I think we were in our infancy of our JCO PO podcast when we had you first time, and it has been an interesting journey since then. Dr. Shilpa Gupta: Absolutely. Dr. Rafeh Naqash: Well, excited to talk to you about this article that you published. Wanted to first understand what is the genomic landscape of urothelial cancer in general, and why should we be interested in FGFR3 alterations specifically? Dr. Shilpa Gupta: Bladder cancer or urothelial cancer is a very heterogeneous cancer. And while we find there is a lot of mutations can be there, you know, like BRCA1, 2, in HER2, in FGFR, we never really understood what is driving the cancer. Like a lot of old studies with targeted therapies did not really work. For example, we think VEGF can be upregulated, but VEGF inhibitors have not really shown definite promise so far. Now, FGFR3 receptor is the only therapeutic target so far that has an FDA approved therapy for treating metastatic urothelial cancer patients, and erdafitinib was approved in 2019 for patients whose tumors overexpressed FGFR3 mutations, alterations, or fusions. And in the landscape of bladder cancer, it is important because in patients with non-muscle invasive bladder cancer, about 70 to 80% patients can have this FGFR3. But as patients become metastatic, the alterations are seen in, you know, only about 10% of patients. So the clinical trials that got the erdafitinib approved actually used archival tumor from local cancer. So when in the real world, we don't see a lot of patients if we are trying to do metastatic lesion biopsies. And why it is important to know this is because that is the only targeted therapy available for our patients right now. Dr. Rafeh Naqash: Thank you for giving us that overview. Now, on the clinical side, there is obviously some interesting data for FGFR3 on the mutation side and the fusion side. In your clinical practice, do you tend to approach these patients differently when you have a mutation versus when you have a fusion? Dr. Shilpa Gupta: We can use the treatment regardless of that. Dr. Rafeh Naqash: I recently remember I had a patient with lung cancer, squamous lung cancer, who also had a synchronous bladder mass. And the first thought from multiple colleagues was that this is metastatic lung. And interestingly, the liquid biopsy ended up showing an FGFR3-TACC fusion, which we generally don't see in squamous lung cancers. And then eventually, I was able to convince our GU colleagues, urologists, to get a biopsy. They did a transurethral resection of this tumor, ended up being primary urothelial and synchronous lung, which again, going back to the FGFR3 story, I saw in your paper there is a mention of FGFR3-TACC fusions. Anything interesting that you find with these fusions as far as biology or tumor behavior is concerned? Dr. Shilpa Gupta: We found in our paper of all the patients that were sequenced that 20% had the pathognomonic FGFR3 alteration, and the most common were the S249C, and the FGFR3-TACC3 fusion was in 45 patients. And basically I will say that we didn't want to generate too much as to fusion or the differences in that. The key aspect of this paper was that historically there were these anecdotal reports saying that patients who have FGFR alterations or mutations, they may not respond well to checkpoint inhibitors because they have the luminal subtype. And these were backed by some preclinical data and small anecdotal reports. But since then, we have seen that, and that's why a lot of people would say that if somebody's tumor has FGFR3, don't give them immunotherapy, give them erdafitinib first, right? So then we had this Phase 3 trial called the THOR trial, which actually showed that giving erdafitinib before pembrolizumab was not better. That debunked that myth, and we are actually reiterating that because in our work we found that patients who had FGFR3 alterations or fusions, and if they also have TMB-high, they actually respond very well to single agent immunotherapy. And that is, I think, very important because it tells us that we are not really seeing that so-called potential of resistance to immunotherapy in these patients. So to answer your question, yeah, we did see those differences, but I wouldn't say that any one marker is more prominent. Dr. Rafeh Naqash: The analogy is kind of similar to what we see in lung cancer with these mutations called STK11/KEAP1, which are also present in some other tumors. And one of the questions that I don't think has been answered is when you have in lung cancer, if you extrapolate this, where doublet or single agent immunotherapy doesn't do as well in tumors that are STK11 mutated. But then if you have a high TMB, question is does that TMB supersede or trump the actual mutation? Could that be one reason why you see the TMB-high but FGFR3 altered tumors in your dataset responding or having better outcomes to immunotherapy where potentially there is just more neoantigens and that results in a more durable or perhaps better response to checkpoint therapy? Dr. Shilpa Gupta: It could be. But you know, the patients who have FGFR alterations are not that many, right? So we have already seen that just patients with TMB-high respond very well to immunotherapy. Our last podcast was actually on that, regardless of PD-L1 that was a better predictor of response to immunotherapy. So I think it's not clear if this is adding more chances of response or not, because either way they would respond. But what we didn't see, which was good, that if they had FGFR3, it's not really downplaying the fact that they have TMB-high and that patients are not responding to immunotherapy. So we saw that regardless, and that was very reassuring. Dr. Rafeh Naqash: So if tomorrow in your clinic you had an individual with an FGFR3 alteration but TMB-high, I guess one could be comfortable just going ahead with immunotherapy, which is what the THOR trial as you mentioned. Dr. Shilpa Gupta: Yes, absolutely. And you know, when you look at the toxicity profiles of pembrolizumab and erdafitinib, really patients really struggle with using the FGFR3 inhibitors. And of course, if they have to use it, we have to, and we reserve it for patients. But it's not an easy drug to tolerate. Currently the landscape is such that, you know, frontline therapy has now evolved with an ADC and immunotherapy combinations. So really if patients progress and have FGFR3 alterations, we are using erdafitinib. But let's say if there were a situation where a patient has had chemotherapy, no immunotherapy, and they have FGFR3 upregulation and TMB-high, yes, I would be comfortable with using only pembrolizumab. And that really ties well together what we saw in the THOR trial as well. Dr. Rafeh Naqash: Going to the clinical applications, you mentioned a little bit of this in the manuscript, is combination therapies. You alluded to it a second back. Everything tends to get combined with checkpoint therapy these days, as you've seen with the frontline urothelial, pembrolizumab with an ADC. What is the landscape like as far as some of these FGFR alterations are concerned? Is it reasonable to combine some of those drugs with immune checkpoint therapy? And what are some of the toxicity patterns that you've potentially seen in your experience? Dr. Shilpa Gupta: So there was indeed a trial called the NORSE trial. It was a randomized trial but not a comparative cohort, where they looked at FGFR altered patients. And when they combined erdafitinib plus cetrelimab, that did numerically the response rates were much higher than those who got just erdafitinib. So yeah, the combination is definitely doable. There is no overlapping toxicities. But unfortunately that combination has not really moved forward to a Phase 3 trial because it's so challenging to enroll patients with such kind of rare mutations on large trials, especially to do registration trials. And since then the frontline therapy has evolved to enfortumab vedotin and pembrolizumab. I know there is an early phase trial looking at a next generation FGFR inhibitor. There is a triplet combination looking in Phase 1 setting with a next generation FGFR inhibitor with EV-pembro. However, it's not a randomized trial. So you know, I worry about such kinds of combinations where we don't have a path for registration. And in the four patients that have been treated, four or five patients in the early phase as a part of basket trial, the toxicities were a lot, you know, when you combine the EV-pembro and an FGFR3 inhibitor, we see more and more toxicity. So the big question is do we really need the "kitchen sink" approach when we have a very good doublet, or unless the bar is so high with the doublet, like what are we trying to add at the expense of patient toxicity and quality of life is the big question in my mind. Dr. Rafeh Naqash: Going back to your manuscript specifically, there could be a composite biomarker. You point out like FGFR in addition to FGFR TMB ends up being predictive prognostic there. So that could potentially be used as an approach to stratify patients as far as treatment, whether it's a single agent versus combination. Maybe the TMB-low/FGFR3 mutated require a combination, but the TMB-high/FGFR mutated don't require a combination, right? Dr. Shilpa Gupta: No, that's a great point, yeah. Dr. Rafeh Naqash: But again, very interesting, intriguing concepts that you've alluded to and described in this manuscript. Now, a quick take on how things have changed in the bladder cancer space in the last two years. We did a podcast with you regarding some biomarkers as you mentioned two years back. So I really would like to spend the next minute to two to understand how have things changed in the bladder cancer space? What are some of the exciting things that were not there two years back that are in practice now? And how do you anticipate the next two years to be like? Maybe we'll have another podcast with you in another two years when the space will have changed even more. Dr. Shilpa Gupta: Certainly a lot has happened in the two years, you know. EV-pembro became the universal frontline standard, right? We have really moved away from cisplatin eligibility in metastatic setting because anybody would benefit from EV-pembro regardless of whether they are candidates for cisplatin or not, which historically was relevant. And just two days ago, we saw that EV-pembro has now been approved for localized bladder cancer for patients who are cisplatin ineligible or refusing. So, you know, this very effective regimen moving into earlier setting, we now have to really think of good treatment options in the metastatic setting, right? So I think that's where a lot of these novel combinations may come up. And what else we've seen is in a tumor agnostic trial called the DESTINY-PanTumor trial, patients who had HER2 3+ on immunohistochemistry, we saw the drug approval for T-DXd, and I think that has kind of reinvigorated the interest in HER2 in bladder cancer, because in the past targeting HER2 really didn't work. And we still don't know if HER2 is a driver or not. And at ESMO this year, we saw an excellent study coming out of China with DV which is targeting HER2, and toripalimab, which is a Chinese checkpoint inhibitor, showing pretty much similar results to what we saw with EV-pembro. Now, you know, not to do cross-trial comparisons, but that was really an amazing, amazing study. It was in the presidential session. And I think the big question is: does that really tell us that HER2-low patients will not benefit? Because that included 1+, 2+, 3+. So that part we really don't know, and I think we want to study from the EV-302 how the HER2 positive patients did with EV and pembro. So that's an additional option, at least in China, and hopefully if it gets approved here, there is a trial going on with DV and pembro. And lastly, we've seen a very promising biomarker, like ctDNA, for the first time in bladder cancer in the adjuvant setting guiding treatment with adjuvant atezolizumab. So patients who were ctDNA positive derived overall survival and recurrence-free survival benefit. So that could help us select moving forward with more studies. We can spare unnecessary checkpoint inhibitors in patients who are not going to benefit. So I think there is a lot happening in our field, and this will help do more studies because we already have the next generation FGFR inhibitors which don't have the toxicities that erdafitinib comes with. And combining those with these novel ADCs and checkpoint inhibitors, you know, using maybe TMB as a biomarker, because we really need to move away from PD-L1 in bladder cancer. It's shown no utility whatsoever, but TMB has. Dr. Rafeh Naqash: Well, thank you so much, Shilpa, for that tour de force of how things have changed in bladder cancer. There used to be a time when lung and melanoma used to lead this space in terms of the number of approvals, the biomarker development. It looks like bladder cancer is shifting the trend at this stage. So definitely exciting to see all the new changes that are coming up. I'd like to spend another minute and a half on your career. You've obviously been a leader and example for many people in the GU space and beyond. Could you, for the sake of our early career especially, the trainees and other listeners, describe how you focused on things that you're currently leading as a leader, and how you shaped your career trajectory over the last 10 years? Dr. Shilpa Gupta: That's a really important question, Rafeh, and you and I have had these discussions before, you know, being an IMG on visas like you, and being in different places. I think I try to make the most of it, you know, instead of focusing on the setbacks or the negative things. Like tried to grab the opportunities that came along. When I was at Moffitt, got to get involved with the Phase 1 trial of pembrolizumab in different tumor types. And just keeping my options open, you know, getting into the bladder cancer at that time when I wanted to really do only prostate, but it was a good idea for me to keep my options open and got all these opportunities that I made use of. I think an important thing is to, like you said, you know, have a focus. So I am trying to focus more on biomarkers that, you know, we know that 70% patients will respond to EV-pembro, right? But what about the remaining 30%? Like, so I'm really trying to understand what determines hyperprogressors with such effective regimens who we really struggle with in the clinic. They really don't do well with anything we give them after that. So we are doing some work with that and also trying to focus on PROs and kind of patient-reported outcomes. And a special interest that I've now developed and working on it is young-onset bladder cancer. You know, the colorectal cancer world has made a lot of progress and we are really far behind. And bladder cancer has historically been a disease of the elderly, which is not the case anymore. We are seeing patients in their 30s and 40s. So we launched this young-onset bladder cancer initiative at a Bladder Cancer Advocacy Network meeting and now looking at more deep dive and creating a working group around that. But yeah, you know, I would say that my philosophy has been to just take the best out of the situation I'm in, no matter where I am. And it has just helped shape my career where I am, despite everything. Dr. Rafeh Naqash: Well, thank you again. It is always a pleasure to learn from your experiences and things that you have helped lead. Appreciate all your insights, and thank you for publishing with JCO PO. Hopefully we will see more of your biomarker work being published and perhaps bring you for another podcast in a couple of years. Dr. Shilpa Gupta: Yeah, thank you, Rafeh, for the opportunity. And thanks to JCO PO for making these podcasts for our readers. So thanks a lot. Dr. Rafeh Naqash: Thank you for listening to JCO Precision Oncology Conversations. Don't forget to give us a rating or review and be sure to subscribe so you never miss an episode. You can find all ASCO shows at asco.org/podcast. The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. DISCLOSURES Dr. Shilpa Gupta Stock and Other Ownership Interests: Company: BioNTech SE,  Nektar Consulting or Advisory Role: Company: Gilead Sciences, Pfizer, Merck, Foundation Medicine, Bristol-Myers Squibb/Medarex, Natera, Astellas Pharma, AstraZeneca, Novartis, Johnson & Johnson/Janssen Research Funding: Recipient: Your Institution Company: Bristol Myers Squibb Foundation, Merck, Roche/Genentech, EMD Serono, Exelixis, Novartis, Tyra Biosciences, Pfizer, Convergent Therapeutics, Acrivon Therapeutics, Flare Therapeutics, Amgen Travel, Accommodations, Expenses: Company: Pfizer, Astellas Pharma, Merck    

The PM Team w/Poni & Mueller
HOUR 3 - Draft clock alteration, ALL ACCESS, Debrief

The PM Team w/Poni & Mueller

Play Episode Listen Later Dec 10, 2025 34:25


Will we see Aaron Rodgers next season? We also got notable NFL Draft news that the 1st round clock will drop from 10 minutes to 8 minutes per pick. That could be the night the Steelers draft their next QB. We know the Steelers won't show their hand early, but is Rodgers in their plans for next season? Will the Steelers still do everything they can to move up and take one of this year's QBs? Chris suggested allowing the fans to have their dream Mason Rudolph bridge season. There are not many (or any) attractive free agent QBs. ALL ACCESS w/ Aditi – Christmas music began the conversation with Aditi before it jumped to the future for old QBs like Aaron Rodgers and Philip Rivers. What should the strategy be for the Steelers going into the draft? If Rodgers doesn't trust Roman Wilson, what does that mean for his future? Aditi talked about the Dolphins pre-snap motion that is ‘a lot of eye candy.' Aditi gave a bit of a scouting report on the Dolphins as they come into town Monday night. She said the offensive line in Miami has been one of the best in football. Donny Football Debrief – A New York Giants coach was fired over their bye week and the final straw was a pretty funny reason. And is it Kenny Pickett time in Vegas? The Raiders take on the Eagles Sunday afternoon.

Cutting Through the Matrix with Alan Watt Podcast (.xml Format)
Oct. 26, 2025 "Cutting Through the Matrix" with Alan Watt --- Redux (Educational Talk From the Past): "New Order Schemes to Track Your Dreams"

Cutting Through the Matrix with Alan Watt Podcast (.xml Format)

Play Episode Listen Later Oct 26, 2025 74:51


--{ "New Order Schemes to Track Your Dreams"}-- CTTM book club and other big projects - AI companion robots for elderly people - “RFID Will Protect You, Says Industry Lawyer” by Mark Baard -- RFID (Radio Frequency Identification) - Department of Homeland Security - “Public Safety” - Chipping business - ID cards, passports - 911 - British ID passport - Public-Private - Psychopathic terms - Remote tracking devices to “protect you” - Tagging and tracking store items from factory floor to checkout counter and beyond [this is what the blockchain is really all about] - Data mining - Pyramid capstone at top - -- Alan: “If you don't know your history, you are doomed to repeat it” -- Movements toward “Democracy” - Holding power by keeping pulse of public - World elite and fudal serfdom - Specialized priesthoods - Machiavellian techniques - New World Order is always becoming New - Allegiances sworn to royalty - Oaths - Doublethink - Tribal psychology - Population reduction - Global Warming - Psychopaths will blame others; rationalization of anything - “Founding Fathers” many were verified Freemasons - Bill Cooper; those who want to save the system - Great Depression - Tax men - Legalistic statements by media; people have been told - Everyone is making decisions -Migration - Agenda 21 - Cloning and genetic enhancement, Plato's The Republic- Breeding qualities in or out - Looking at alternate ways of getting through all this - Why save an illusion? - Property taxes; inhumane system - Ignorance is a choice - Relationships - Awake individuals - Conscience - Psychopathic egocentric culture - Conscience brings responsibility, pointing out what is, what will be, what can be - Not caring is a choice; those through the ages that could understand with clarity -Teaching others, Age of Aquarius brings in final solution for elite -Trinity of 2 in 1 - Duad - High occult - 21st Century (2 in 1) - Completion of part of plan - Time to pass on knowledge is running out - Children's conditioning for chips and virtual reality - Infiltration of mass movements - Personal choices on a daily basis - Risk of complete oblivion of conscious mind - Silence is acquiescence - Empathy for others ensures your own survival - Selection of particular qualities for future humans - Alteration then chipping would bring non-persons.

Inside Out Style
374: Your colour questions answered about alteration, pants and Pops of 3.

Inside Out Style

Play Episode Listen Later Sep 5, 2025 13:24


In This Episode 0.12 I am tallish (5ft 8in) and not slender (UK size 16), and I like clothes. I can describe the kind I want – but they don’t exist. Right now, I’d like a replacement for a 20 year old unlined slouchy blazer In a greeny grey (or greyish green) that goes with…

Forbidden Knowledge News
End of the Millennial Reign of Christ & the Parasitic Timeline Alteration | Guy Anderson

Forbidden Knowledge News

Play Episode Listen Later Sep 2, 2025 62:53 Transcription Available


Guy's website https://thetartarianempire.co.uk/Doors of Perception is available now on Amazon Prime!https://watch.amazon.com/detail?gti=amzn1.dv.gti.8a60e6c7-678d-4502-b335-adfbb30697b8&ref_=atv_lp_share_mv&r=webDoors of Perception official trailerhttps://youtu.be/F-VJ01kMSII?si=Ee6xwtUONA18HNLZMerchhttps://fknstore.net/Start your microdosing journey with BrainsupremeGet 15% off your order here!!https://brainsupreme.co/FKN15Book a free consultation with Jennifer Halcame Emailjenniferhalcame@gmail.comFacebook pagehttps://www.facebook.com/profile.php?id=61561665957079&mibextid=ZbWKwLWatch The Forbidden Documentary: Occult Louisiana on Tubi: https://link.tubi.tv/pGXW6chxCJbC60 PurplePowerhttps://go.shopc60.com/FORBIDDEN10/or use coupon code knowledge10FKN Link Treehttps://linktr.ee/FKNlinksForbidden Knowledge Network https://forbiddenknowledge.news/ Make a Donation to Forbidden Knowledge News https://www.paypal.me/forbiddenknowledgenehttps://buymeacoffee.com/forbiddenJohnny Larson's artworkhttps://www.patreon.com/JohnnyLarsonSign up on Rokfin!https://rokfin.com/fknplusPodcastshttps://www.spreaker.com/show/forbiddenAvailable on all platforms Support FKN on Spreaker https://spreaker.page.link/KoPgfbEq8kcsR5oj9FKN ON Rumblehttps://rumble.com/c/FKNpGet Cory Hughes books!Lee Harvey Oswald In Black and White https://www.amazon.com/dp/B0FJ2PQJRMA Warning From History Audio bookhttps://buymeacoffee.com/jfkbook/e/392579https://www.buymeacoffee.com/jfkbookhttps://www.amazon.com/Warning-History-Cory-Hughes/dp/B0CL14VQY6/ref=mp_s_a_1_1?crid=72HEFZQA7TAP&keywords=a+warning+from+history+cory+hughes&qid=1698861279&sprefix=a+warning+fro%2Caps%2C121&sr=8-1https://coryhughes.org/YouTube https://youtube.com/@fknclipspBecome Self-Sufficient With A Food Forest!!https://foodforestabundance.com/get-started/?ref=CHRISTOPHERMATHUse coupon code: FORBIDDEN for discountsOur Facebook pageshttps://www.facebook.com/forbiddenknowledgenewsconspiracy/https://www.facebook.com/FKNNetwork/Instagram @forbiddenknowledgenews1@forbiddenknowledgenetworkXhttps://x.com/ForbiddenKnow10?t=uO5AqEtDuHdF9fXYtCUtfw&s=09Email meforbiddenknowledgenews@gmail.comsome music thanks to:https://www.bensound.com/Become a supporter of this podcast: https://www.spreaker.com/podcast/forbidden-knowledge-news--3589233/support.

The KE Report
Cosa Resources – Summer Drill Program Delineates 2kms Strikelength of Graphitic Faulting And Strong Sandstone Alteration Along The Cyclone Trend At The Murphy Lake North Uranium Project

The KE Report

Play Episode Listen Later Aug 29, 2025 18:26


Keith Bodnarchuk, President and CEO, and Andy Carmichael, VP of Exploration of Cosa Resources Corp. (TSXV: COSA) (OTCQB: COSAF) (FSE: SSKU), both join me to review the news released today on August 25th  highlighting that the summer exploration drilling has successfully identified two kilometres of highly prospective strike length characterized by strong sandstone alteration and graphitic faulting at the Cyclone Trend on the Murphy Lake North Project (“MLN”).   MLN is a joint venture between Cosa and Denison Mines Corp. $DML $DNN.US and is located in the eastern Athabasca Basin, Saskatchewan. Cosa is the project operator and holds a 70% interest with Denison holding a 30% interest.   Summer Drilling Highlights:   Two kilometres of strong sandstone structure and alteration identified at the Cyclone trend underlain by large scale graphitic faulting Up to 30 metres of unconformity relief identified at Cyclone Alteration and structure at Cyclone remain open in both directions and follow up drill targets exist along multiple trends Cosa has met its sole-fund obligation and now owns an irrevocable 70% interest in Murphy Lake North   Keith outlines why these results of the Murphy Lake North summer drill program, specifically those at the Cyclone trend, are the most significant to date for Cosa, and further support their thesis and the follow up drill program slated to begin in early 2026.   Andy visually walks us through where the 3,323 metres in eight holes were completed, with one hole being put into the Hurricane trend to follow up winter 2025 drilling results, and then the balance of 7 holes being drilled as the initial reconnaissance of the Cyclone trend.  These results identified over two kilometres of highly prospective strike length and potentially identified an additional unexplored parallel trend to the south. The intensity and continuity of sandstone alteration and structure, both vertically and along strike, is an encouraging indicator of the trend's prospectivity. Basement structures intersected two kilometres apart are textbook examples of major graphitic faults critical to the formation of eastern Athabasca uranium deposits. With an average depth to the unconformity of roughly 250 metres, the Cyclone trend is incredibly well situated for the discovery of relatively shallow mineralization.   Andy showcased photos of the drill core, and that they'll be awaiting the geochemical results, to then vector into to the future follow up drill targets.   Wrapping up we looked ahead to the follow up program for early 2026, where Cosa and Denison elected to leave much of the drill equipment on site to minimize the time and cost to resume early next year.  Additionally, Keith mentioned that Darby project, another key property in the Cosa/Denison JV agreement will be getting its first drilling at high-priority targets in 2026.     If you have any questions for Keith or Andy regarding Cosa Resources, then please email them in to me at Shad@kereport.com.     Click here to follow the most recent news from Cosa Resources

CISSP Cyber Training Podcast - CISSP Training Program
CCT 272: Confidentiality, Integrity, Availability, Authenticity, and Nonrepudiation (CISSP Domain 1.2)

CISSP Cyber Training Podcast - CISSP Training Program

Play Episode Listen Later Aug 18, 2025 41:58 Transcription Available


Send us a textCheck us out at:  https://www.cisspcybertraining.com/Get access to 360 FREE CISSP Questions:  https://www.cisspcybertraining.com/offers/dzHKVcDB/checkoutGet access to my FREE CISSP Self-Study Essentials Videos:  https://www.cisspcybertraining.com/offers/KzBKKouvThe core principles of cybersecurity aren't just theoretical concepts—they're the practical foundation every security professional needs to master. In this deep-dive episode, Sean Gerber breaks down the critical components of Domain 1.2 of the CISSP exam, unpacking confidentiality, integrity, availability, authenticity, and non-repudiation in clear, actionable terms.Starting with breaking news about Microsoft ending Windows 10 support on October 14th, Sean highlights the urgent security implications for organizations still running this widely-embedded operating system. He emphasizes the importance of comprehensive inventory management—especially for IoT devices that may contain embedded Windows components—and the available extension options for critical systems.The heart of the episode delivers a comprehensive exploration of the CIA triad. Sean walks through each element with real-world examples: confidentiality through encryption and access controls; integrity via change management and validation processes; and availability through redundant systems and business continuity planning. But he doesn't stop there. The discussion expands to cover the DAD triad (Disclosure, Alteration, Destruction) which helps identify security failures, and the AAA framework (Authentication, Authorization, Accounting) that provides essential security controls.What makes this episode particularly valuable is Sean's practical advice drawn from 25 years of cybersecurity experience. He emphasizes the importance of defense-in-depth strategies, network segmentation, and prioritizing critical systems rather than attempting to fix everything at once—"eating the elephant one toenail at a time." His methodical approach helps listeners understand not just the concepts themselves, but how to implement them effectively in real-world environments.Whether you're preparing for the CISSP exam or looking to strengthen your organization's security posture, this episode provides the foundational knowledge and practical strategies you need. Visit CISSP Cyber Training for free study materials, practice questions, and mentoring options to accelerate your cybersecurity career.Support the showGain exclusive access to 360 FREE CISSP Practice Questions delivered directly to your inbox! Sign up at FreeCISSPQuestions.com and receive 30 expertly crafted practice questions every 15 days for the next 6 months—completely free! Don't miss this valuable opportunity to strengthen your CISSP exam preparation and boost your chances of certification success. Join now and start your journey toward CISSP mastery today!

Forbidden Knowledge News
FKN Classics Double Feature! | CJ Rodriguez - Human Alteration | Rob Gauthier - Reptilian Channel

Forbidden Knowledge News

Play Episode Listen Later Aug 15, 2025 146:18 Transcription Available


Doors of Perception is available now on Amazon Prime!https://watch.amazon.com/detail?gti=amzn1.dv.gti.8a60e6c7-678d-4502-b335-adfbb30697b8&ref_=atv_lp_share_mv&r=webDoors of Perception official trailerhttps://youtu.be/F-VJ01kMSII?si=Ee6xwtUONA18HNLZMerchhttps://fknstore.net/Start your microdosing journey with BrainsupremeGet 15% off your order here!!https://brainsupreme.co/FKN15Book a free consultation with Jennifer Halcame Emailjenniferhalcame@gmail.comFacebook pagehttps://www.facebook.com/profile.php?id=61561665957079&mibextid=ZbWKwLWatch The Forbidden Documentary: Occult Louisiana on Tubi: https://link.tubi.tv/pGXW6chxCJbC60 PurplePowerhttps://go.shopc60.com/FORBIDDEN10/or use coupon code knowledge10FKN Link Treehttps://linktr.ee/FKNlinksForbidden Knowledge Network https://forbiddenknowledge.news/ Make a Donation to Forbidden Knowledge News https://www.paypal.me/forbiddenknowledgenehttps://buymeacoffee.com/forbiddenJohnny Larson's artworkhttps://www.patreon.com/JohnnyLarsonSign up on Rokfin!https://rokfin.com/fknplusPodcastshttps://www.spreaker.com/show/forbiddenAvailable on all platforms Support FKN on Spreaker https://spreaker.page.link/KoPgfbEq8kcsR5oj9FKN ON Rumblehttps://rumble.com/c/FKNpGet Cory Hughes books!Lee Harvey Oswald In Black and White https://www.amazon.com/dp/B0FJ2PQJRMA Warning From History Audio bookhttps://buymeacoffee.com/jfkbook/e/392579https://www.buymeacoffee.com/jfkbookhttps://www.amazon.com/Warning-History-Cory-Hughes/dp/B0CL14VQY6/ref=mp_s_a_1_1?crid=72HEFZQA7TAP&keywords=a+warning+from+history+cory+hughes&qid=1698861279&sprefix=a+warning+fro%2Caps%2C121&sr=8-1https://coryhughes.org/YouTube https://youtube.com/@fknclipspBecome Self-Sufficient With A Food Forest!!https://foodforestabundance.com/get-started/?ref=CHRISTOPHERMATHUse coupon code: FORBIDDEN for discountsOur Facebook pageshttps://www.facebook.com/forbiddenknowledgenewsconspiracy/https://www.facebook.com/FKNNetwork/Instagram @forbiddenknowledgenews1@forbiddenknowledgenetworkXhttps://x.com/ForbiddenKnow10?t=uO5AqEtDuHdF9fXYtCUtfw&s=09Email meforbiddenknowledgenews@gmail.comsome music thanks to:https://www.bensound.com/Become a supporter of this podcast: https://www.spreaker.com/podcast/forbidden-knowledge-news--3589233/support.

Music Seeds: The Music That Made Us
Emotional Alteration in Music Part 3

Music Seeds: The Music That Made Us

Play Episode Listen Later Jul 19, 2025 70:23


Episode 82!What can I say about part 3 of this episode? We discuss biopics, documentaries, The late Brian Wilson, and Sly of Sly and the Family Stone.The excellent documentary ' Becoming Led Zeppelin', when an artist should hang it up, and when we want bands to come back together.Depeche Mode, just a little, hope to discuss some more in the future. Alternative acts and their influences. Soundgarden / Chris Cornell and his legacy. The Rock N' Roll Hall of Fame inductees. And the SNL 50th Music Documentary by Questlove. And so much more.The episode alternates between conversations, and this is the third part of a three-part series. I do apologize for a little cursing.Thank you for listening!I hope you enjoy it.You can get a hold of us through:Email at:ozomatfan87@gmail.comSocial Media:Facebook@MusicMadeSeeds"Music Seeds"johnny0520@snapchatInstagram is musicmadeusjohnnySupport is on Patreon= https://www.patreon.com/bePatron?u=48542707Thank you for listening!I hope you enjoy it.You can get a hold of us through:Email at:ozomatfan87@gmail.comSocial Media:Facebook@MusicMadeSeeds"Music Seeds"johnny0520@snapchatInstagram is musicmadeusjohnnySupport is on Patreon= https://www.patreon.com/bePatron?u=48542707Please subscribe wherever you get podcasts ★ Support this podcast on Patreon ★

Music Seeds: The Music That Made Us
Emotional Alteration in Music Part 2

Music Seeds: The Music That Made Us

Play Episode Listen Later Jul 6, 2025 43:24


Episode 81!Very excited about part 2 of this episode! Considering what we talked about when this was recorded happened just this weekend.The 'Back to Beginnings Black Sabbath' Tribute to Ozzy show we discuss, and how that ties in with the previous topic of hanging it up for a music artist.Also, INXS and their lead singer, Michael Hutchence. Depeche Mode, Led Zeppelin, Pearl Jam, and their song 'Give To Fly'. And so much more.The episode alternates between conversations, and this is the second part of a three-part series.Thank you for listening!I hope you enjoy it.You can get a hold of us through:Email at:ozomatfan87@gmail.comSocial Media:Facebook@MusicMadeSeeds"Music Seeds"johnny0520@snapchatInstagram is musicmadeusjohnnySupport is on Patreon= https://www.patreon.com/bePatron?u=48542707Thank you for listening!I hope you enjoy it.You can get a hold of us through:Email at:ozomatfan87@gmail.comSocial Media:Facebook@MusicMadeSeeds"Music Seeds"johnny0520@snapchatInstagram is musicmadeusjohnnySupport is on Patreon= https://www.patreon.com/bePatron?u=48542707Please subscribe wherever you get podcasts. ★ Support this podcast on Patreon ★

Fantasy for the Ages
MOST OVERLOOKED SFF Books of the 1970s Revealed?

Fantasy for the Ages

Play Episode Listen Later Jul 3, 2025 30:30


Get ready to discover the hidden gems of science fiction and fantasy literature! In this episode, Jim's counting down the most overlooked SFF books of the 1970s that deserve more attention. From forgotten classics to under-appreciated authors, we're diving into a decade that shaped the genre. Join us as we explore the lesser-known SFF novels of the 1970s that will make you wonder how you ever missed them. Whether you're a seasoned SFF fan or just looking to expand your reading list, this episode is for you!#FantasyForTheAges #SFF #SciFi #ScienceFiction #Fantasy #UnderratedBooks #FantasyFiction #BookRecommendations #TBR #HiddenGems #booktube #booktuberWant to purchase books/media mentioned in this episode?The Alteration: https://t.ly/PSwgQAnd Chaos Died: https://t.ly/eYohvThe Black Corridor: https://t.ly/ClJxpThe Book of Skulls: https://t.ly/nmgFrDhalgren: https://t.ly/NywfiDoctor Rat: https://t.ly/V7jMAThe Dream Master: https://t.ly/HeXEBDying Inside: https://t.ly/VsNlfThe Embedding: https://t.ly/z_R2SEngine Summer: https://t.ly/UYrz_The Female Man: https://t.ly/Cio7JFlow My Tears, the Policeman Said: https://t.ly/OODnPThe Forgotten Beasts of Eld: https://t.ly/nPy5rThe Godwhale: https://t.ly/xnOR2High Rise: https://t.ly/zI6XUThe Hour of the Star: https://t.ly/IPPKKIn the Ocean of Night: https://t.ly/rhINIThe Inverted World: https://t.ly/BX0ctThe Iron Dream: https://t.ly/ZU2f4On Wings of Song: https://t.ly/kQrhLThe Riddle-Master of Hed: https://t.ly/3rjPxRiddley Walker: https://t.ly/KA5mxThe Road to Corlay: https://t.ly/3wg9QTime and Again: https://t.ly/5fvsOWalk to the End of the World: https://t.ly/1Cb9KWatership Down: https://t.ly/Nx5-yWhere Late the Sweet Birds Sang: https://t.ly/1Vy50Who Fears the Devil?: https://t.ly/pKqnNWoman on the Edge of Time: https://t.ly/DrrgOThe Year of the Quiet Sun: https://t.ly/Vtiy0Ways to connect with us:Support us on Patreon: https://www.patreon.com/FantasyForTheAges Follow Jim/Father on Goodreads: https://www.goodreads.com/user/show/13848336-jim-scriven Join us on Discord: https://discord.gg/jMWyVJ6qKk Follow us on "X": @Fantasy4theAges Follow us on Blue Sky: @fantasy4theages.bsky.socialFollow us on Instagram: fantasy_for_the_ages Follow us on Mastodon: @FantasyForTheAges@nerdculture.de Email us: FantasyForTheAges@gmail.com Check out our merch: https://www.newcreationsbyjen.com/collections/fantasyfortheagesJim's Microphone: Blue Yeti https://tinyurl.com/3shpvhb4 ————————————————————————————Music and video elements licensed under Envato Elements:https://elements.envato.com/

Music Seeds: The Music That Made Us
Emotional Alteration in Music Part 1

Music Seeds: The Music That Made Us

Play Episode Listen Later Jun 29, 2025 43:31


Welcome back, folks.In this episode, we discuss what songs or music makes us emotional, and what we feel with music.The bands we bring up are: Metallica / Trent Reznor and Nine Inch Nails / U2 / Kansas / Foreigner / Journey / Depeche Mode / Tom Morello and Rage Against The Machine / Billy Corgan / Halsey / Anton Corbijn / Nitzer Ebb, amongst others.We also bring up the topic, when a band should call it quits?The episode goes back and forth in conversation, and this is the first part of a three part series.Thank You for listening!I hope you enjoy it.You can get a hold of us through:Email at:ozomatfan87@gmail.comSocial Media:Facebook@MusicMadeSeeds"Music Seeds"johnny0520@snapchatInstagram is musicmadeusjohnnySupport is on Patreon= https://www.patreon.com/bePatron?u=48542707Please Thank You for listening!I hope you enjoy it.You can get a hold of us through:Email at:ozomatfan87@gmail.comSocial Media:Facebook@MusicMadeSeeds"Music Seeds"johnny0520@snapchatInstagram is musicmadeusjohnnySupport is on Patreon= https://www.patreon.com/bePatron?u=48542707Please Subscribe wherever you get podcasts. ★ Support this podcast on Patreon ★

The Realist & The Visionary
Black Mirror Series 11

The Realist & The Visionary

Play Episode Listen Later May 24, 2025 36:03


Dutch & Tena discuss Black Mirror Season 7 Episode 2 entitled Bête Noire.This episode brilliantly explores the concept of the Mandela Effect, where the collective memory of a group can differ from the actual reality. As we dissect the plot, we see how the character Maria, a chocolate maker, encounters Verity, a former classmate who wields a peculiar device that can alter reality itself.https://www.therealistthevisionary.comBecome a supporter of this podcast: https://www.spreaker.com/podcast/the-realist-the-visionary--3304218/support.

City Breaks
Amsterdam Episode 04 The Churches of Amsterdam

City Breaks

Play Episode Listen Later Apr 9, 2025 23:49


The churches of Amsterdam are not always what they seem.  One is more of a national memorial, another is an art gallery and concert venue.  A third is a museum where you can learn the story of the hidden churches which opened in the 17th century and where worshippers gathered for over 200 years.  They key factor is a date – 1578 – when an event occurred which changed everything: the Alteration.  This episode explains what happened and then tours half a dozen of the city's churches and explains what you can expect to find if you visit them today.   Reading Suggestions  Amsterdam A Brief Life of the City by Geert Mak Amsterdam A History of the World's Most Liberal City by Russell Shorto The Invention of Amsterdam A History of the World's Greatest City in 10 Walks by Ben Coates Links for this post The Begijnhof The Oude Kerk The Nieuwe Kerk The Westerkerk The Noorderkerk    St Nicholas Our Lord in the Attic

NFPA Journal Podcast
The Construction Fire Problem

NFPA Journal Podcast

Play Episode Listen Later Apr 8, 2025 31:40


As the weather in the Northern Hemisphere starts to shift to spring and construction season gears up, we revisist an episode from 2021 about the costly ongoing problem of fires in buildings under construction. In the United States, there's a fire in a building under construction or renovation every hour and a half, according to NFPA data. On this podcast, Angelo speaks with Kevin Carr (4:15), NFPA staff liaison to NFPA 241, Standard for Safeguarding Construction, Alteration, and Demolition Operations, to learn more about construction site fires and how to prevent them. Plus, a safety executive with a large Maryland-based construction company and the chair of the NFPA 241 technical committee weigh in on why they think NFPA 241 is underutilized and how that could change (22:24). Links: Read more about the latest edition of NFPA 241 and NFPA trainings related to construction site fire safety: https://www.nfpa.org/safetyfirst

The KE Report
Cosa Resources – Murphy Lake North Uranium Project Maiden Drill Program Hits Alteration Zone And 2 KM Strike Extension Of The Hurricane Trend

The KE Report

Play Episode Listen Later Mar 31, 2025 14:06


Keith Bodnarchuk, President and CEO, and Andy Carmichael, VP of Exploration of Cosa Resources Corp (TSX-V: COSA) (OTCQB: COSAF), both join me to review the news released on March 20, 2025 reporting that the inaugural drill program has confirmed that the Murphy Lake North Uranium Project contains up to 2 kilometres strike length of the extension of geology underpinning the Hurricane deposit. Murphy Lake North is a joint venture between Cosa and Denison Mines Corp. (TSX: DML) (NYSE American: DNN) and is located in the eastern Athabasca Basin, Saskatchewan. Cosa is the project operator and holds a 70% interest with Denison holding a 30% interest.   Highlights   Located and defined the Hurricane trend extension within Murphy Lake North, the primary objective of the inaugural drilling campaign   Final drill hole intersected a significant zone of sandstone-hosted alteration and structure, overshooting optimal target by 25 metres; zone is open along strike in both directions and up to two kilometres of untested Hurricane trend strike length is interpreted within Murphy Lake North   Andy walks us through the extension of the Hurricane Trend, where the historic exploration holes were drilled, and where the 4 drill holes from this maiden drill program were located. Not only did they find the right faulting and geological structure, but they also found the alteration zone in the sandstone that tells them they are vectoring in on the right areas. Plans are in development for a fully funded summer drill program to follow up winter drilling results.   Keith wraps us up covering the financial strength of the company, reviews their recent capital raise, and key strategic shareholders.  The company is well-funded to proceed with their summer drill program and initiatives on other properties.     If you have any questions for Keith or Andy regarding Cosa Resources, then please email them in to me at Shad@kereport.com. . * In full disclosure, Shad is a shareholder of Cosa Resources at the time of this recording.   Click here to follow the most recent news from Cosa Resources

Forbidden Knowledge News
Cataclysmic Timelines - Covert Programming & NLP - Past & Future Alteration | Didi Verg

Forbidden Knowledge News

Play Episode Listen Later Mar 4, 2025 66:23


Forbidden Knowledge News
FKN Classics: CUT: Daughters of the West - Alteration & Exploitation of Children | Simon Esler

Forbidden Knowledge News

Play Episode Listen Later Feb 21, 2025 64:10


Make a Donation to Forbidden Knowledge News https://www.paypal.me/forbiddenknowledgenehttps://buymeacoffee.com/forbiddenReconnect to Everything with BrainsupremeGet 25% off your order here!!https://brainsupreme.co/discount/FKN15Subscribe to Cory Hughe's "Bloody History" substackhttps://bloodyhistory.substack.comSign up for the IMT crypto community Imt.networkBook a free consultation with Jennifer Halcame Emailjenniferhalcame@gmail.comFacebook pagehttps://www.facebook.com/profile.php?id=61561665957079&mibextid=ZbWKwLSick of having mediocre health? Transform your health and vitality with Christian Yordanov's program. Learn more and book a free intro call here https://christianyordanov.com/fkn/Watch The Forbidden Documentary: Occult Louisiana on Tubi: https://link.tubi.tv/pGXW6chxCJbC60 PurplePowerhttps://go.shopc60.com/FORBIDDEN10/or use coupon code knowledge10FKN Link Treehttps://linktr.ee/FKNlinksForbidden Knowledge Network https://forbiddenknowledge.news/ Merchhttps://fknstore.net/Johnny Larson's artworkhttps://www.patreon.com/JohnnyLarsonSign up on Rokfin!https://rokfin.com/fknplusPodcastshttps://www.spreaker.com/show/forbiddenAvailable on all platforms Support FKN on Spreaker https://spreaker.page.link/KoPgfbEq8kcsR5oj9FKN ON Rumblehttps://rumble.com/c/FKNpGet Cory Hughes Book!https://www.buymeacoffee.com/jfkbookhttps://www.amazon.com/Warning-History-Cory-Hughes/dp/B0CL14VQY6/ref=mp_s_a_1_1?crid=72HEFZQA7TAP&keywords=a+warning+from+history+cory+hughes&qid=1698861279&sprefix=a+warning+fro%2Caps%2C121&sr=8-1https://coryhughes.org/YouTube https://youtube.com/@fknclipspBecome Self-Sufficient With A Food Forest!!https://foodforestabundance.com/get-started/?ref=CHRISTOPHERMATHUse coupon code: FORBIDDEN for discountsOur Facebook pageshttps://www.facebook.com/forbiddenknowledgenewsconspiracy/https://www.facebook.com/FKNNetwork/Instagram @forbiddenknowledgenews1@forbiddenknowledgenetworkXhttps://x.com/ForbiddenKnow10?t=uO5AqEtDuHdF9fXYtCUtfw&s=09Email meforbiddenknowledgenews@gmail.comsome music thanks to:https://www.bensound.com/Become a supporter of this podcast: https://www.spreaker.com/podcast/forbidden-knowledge-news--3589233/support.

Retro Radio Podcast
Fibber McGee And Molly – House Alteration – Look for an Architect. ep500, 470121Fibber McGee And Molly – House Alteration – Look for an Architect. 470121

Retro Radio Podcast

Play Episode Listen Later Jan 21, 2025 30:28


As the McGee's discuss the name of a good architect, Wallace Wimple visits. Who designed his house? He has a special room to keep his bird books in. Why does…

Today's RDH Dental Hygiene Podcast
Audio Article: A Hygienists' Overview of Halitosis and Taste Alteration

Today's RDH Dental Hygiene Podcast

Play Episode Listen Later Dec 2, 2024 7:37


A Hygienists' Overview of Halitosis and Taste Alteration By Sahar Attari, MS.Ed., BSDH, RDH Original article published on Today's RDH: https://www.todaysrdh.com/a-hygienists-overview-of-halitosis-and-taste-alteration/ Need CE? Start earning CE credits today at ⁠https://rdh.tv/ce⁠  Get daily dental hygiene articles at ⁠https://www.todaysrdh.com⁠ Follow Today's RDH on Facebook: ⁠https://www.facebook.com/TodaysRDH/⁠ Follow Kara RDH on Facebook: ⁠https://www.facebook.com/DentalHygieneKaraRDH/⁠ Follow Kara RDH on Instagram: ⁠https://www.instagram.com/kara_rdh/

Our Film Fathers
Episode 233: Upgraded Batman with Charlie Cebuhar

Our Film Fathers

Play Episode Listen Later Nov 29, 2024 56:49


We brought on our friend and first time dad, Charlie Cebuhar to discuss the underrated neo-noir thriller, Upgrade (2018). With elements of sci-fi and horror added in the mix, this movie has something for everyone. We also talked about the Movie You Can't Wait To Show Your Kid, Batman (1989). The Tim Burton classic started the love for many Batman fans. Let us know your thoughts by leaving a review.Also Play:Cinema Chain Game--------------------------------------------Subscribe, rate, and review:Apple Podcasts: Our Film FathersSpotify: Our Film FathersYouTube: Our Film Fathers---------------------------------------------Follow Us:Instagram: @ourfilmfathersTwitter: @ourfilmfathersEmail: ourfilmfathers@gmail.com

Rugby on Off The Ball
Rugby Daily | Munster put faith in Butler, Bealham's Connacht return, Another Emerging alteration

Rugby on Off The Ball

Play Episode Listen Later Sep 27, 2024 7:42


On Friday's Rugby Daily, Richie McCormack has a plethora of team news ahead of the weekend's URC action. We hear from John Hodnett, as Munster put their faith in Tony Butler for their Italian job. Kok is on familiar ground as Ulster begin their South African double-header. Finlay Bealham makes a timely return to Connacht action. And Simon Easterby's forced into yet another alteration to his Emerging Ireland squad.

Zaneis Baptist Church
WDTBS?, Tattoos, Piercings, Alteration – Ephesians 4:1-3, 32

Zaneis Baptist Church

Play Episode Listen Later Aug 29, 2024 57:49


8/28/24 – Wednesday Day Evening Service. A series on social issues and the Bible. What does the Bible say about ________?

Authentic Biochemistry
Immune Cell Biochemistry. B cells. The XIST-RNP complex with histone epigenetic alteration of Xi -linked genomic loci mediates SLE and RA in women. DJGPhD. 25.6.24. Authentic Biochemistry Podcast

Authentic Biochemistry

Play Episode Listen Later Jun 25, 2024 61:04


References J Biomed Sci 2017. 24, 63. Cell Death & Disease 2014. volume 5, page e1416 Haematologica. 2022 Mar 1; 107(3):721–732 Nucleic Acids Res. 2022 Jan 7; 50(D1): D413–D420 Oncogene 2017. volume 36, pages 5593–5608 Cell. 2021 Apr 1; 184(7):1790–1803.e17. Van Zant and Collins. 1973. "Tuesday's Gone" Lynyrd Skynyrd. https://youtu.be/LJrFxnvcWhc?si=EoL42Pw72Qe_atsz Lennon-McCartney. 1967. "I am the Walrus" Beatles. [Magical Mystery Tour, lp.] https://youtu.be/Ws5klxbI87I?si=QGe84-nMLK4dqgFy Hayward, J. 1967. "Tuesday Afternoon" [Days of Future Passed lp.] Moody Blues https://youtu.be/jmMPBQ4kYKk?si=FjZfDQ6KwCNecphw Mendelsshon, F. 1842 Wedding March C major op 61. https://youtu.be/Z-yUOBft96Y?si=ldxpuxPYTlAExXez --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

THE MAG BITTER TRUTH PODCAST
OUR ALTERATION IS THE GOVERNMENT'S MIND CONTROL

THE MAG BITTER TRUTH PODCAST

Play Episode Listen Later Jun 24, 2024 11:47


magbittertruth.com --- Send in a voice message: https://podcasters.spotify.com/pod/show/mag-bitter-truth/message

Authentic Biochemistry
Immune Cell biochemistry. BCR activation results in mitochondrial alteration in ETC and OXPHOS. DJGPhD. 12June24 Authentic Biochemistry.

Authentic Biochemistry

Play Episode Listen Later Jun 12, 2024 54:57


References Biophys Res Commun. 2024 Mar 12:700:149598. Eur J Pharmacol.2002 May 17;443(1-3):189-96 Nature Immunology2018 volume 19, 871–884 Mozart, WA 1785. C Major String Quartet 19. K 465 (The Dissonance" https://youtu.be/f3oK4XVMARs?si=xjTTKrC0OL-V1xkX --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

Podcast - Secrets of a Bridal Seamstress
The Seamstress Evolution: Attracting Gen Z Clients, Building a Bridal Seamstress Business & Managing Systems and Workflows with Rose McGregor, The Alteration Shop

Podcast - Secrets of a Bridal Seamstress

Play Episode Listen Later Jun 11, 2024 48:19


In this episode, I chat with Rose McGregor, a bridal seamstress from western Kentucky and member of Secrets of a Bridal Seamstress.  Rose shares her journey of learning to sew from her mother, the steps she took to leave David's Bridal to start The Alteration Shop, the importance of updating her marketing strategies to attract Gen Z clients, and the exciting transition to a new commercial space. We also discuss setting prices, managing workflow, and the significance of staying open to new ideas and techniques! Rose is a native of Western Kentucky, growing up in Livingston County, learning to sew from her mother. After high school she earned a degree in tailoring and dressmaking, and then specialized training and experience in bridal and formal wear. Rose is a fashion designer and professional seamstress that wants to help make you feel fabulous and unique on your special day. With over two decades of experience in the formal wear industry, she has the creative abilities to make your dress dreams come true. Connect with Rose: Website: https://www.thealterationsshopky.com Facebook: https://www.facebook.com/thealterationsshopledbetterky Instagram: https://www.instagram.com/thealterationsshopky/ Connect with Nadine:  Check out the NEW exclusive private podcast series, Fitting Packages 101: https://enchanting-sun-77080.myflodesk.com/privatepodcast Become a member: https://secretsofabridalseamstresspodcast.com/membership Instagram: https://www.instagram.com/secretsofabridalseamstress/ TikTok: https://www.tiktok.com/@nadinebozeman YouTube: https://www.youtube.com/@secretsofabridalseamstress

ALAN MULHERN: The Quest & Psychotherapy (Jungian Approach to Healing)
S2 Ep97 Transhumanism. Part 1. Enhancement or deep alteration of human nature?

ALAN MULHERN: The Quest & Psychotherapy (Jungian Approach to Healing)

Play Episode Listen Later May 31, 2024 32:00


A mini series on Transhumanism Transhumanism divides into moderate Transhumanism which believes in an enhanced human condition, and radical Transhumanism which envisages a profound alteration of our bodies and minds, even to the extent of abandoning our biological inheritance and becoming a designed new species. Both visions envisage accelerating technological change. But humans are not in charge of their technologies, rather technology itself is in the driving seat. While the record so far of a highly improved human condition looks good, for example increased life span, as well as impressive increases in GDP and the standard of living, on closer inspection the contemporary situation looks fraught with difficulty and the world economy could well be at an inflection point. Thus, the moderate Transhumanism project would be stalled, even endangered. However, as further episodes will argue this does not apply to radical Transhumanism which  is set to proceed regardless of economic conditions.

The Praiseworld Podcast
Bridesmaids Kicked Out of Church for Indecent Dressing, Dominican Actress' Jesus Dress Red Carpet Alteration, Pour Out by Michael Oyo

The Praiseworld Podcast

Play Episode Listen Later May 28, 2024 64:07


Quote of The Day: “You don't need to know people; you only need to know God. When you know God, people will know you." ~ Bishop David Oyedepo Hosts: Hosts: TOLA Omoniyi, Kanyinsola Omojola, Eyiyemi Olivia

Church of Philadelphia
Time for an Alteration

Church of Philadelphia

Play Episode Listen Later May 26, 2024 48:16


Time for an Alteration Worship Leader Prophetess Bonita Johnson Acts 26:13-18 May 26, 2024 Today, we continue in our current sermon series 'Altar Egos'. Listen to Worship Leader Prophetess Bonita Johnson speak about how we need make alternations. #churchofphila #churchofphiladelphia #buildinglivesthroughlove #loveinaction #2024sermon #onlinechurch  https://znap.link/churchofphila To support this ministry and help us continue to build God's kingdom click here: http://www.churchofphila.com  If you've just made a decision for Christ, please respond HERE: http://www.churchofphila.com  Our vision is to provide a place where people of all colors, creeds, and nationalities can come together and worship the Living Savior who is Jesus Christ, the Son of the Living God.  Connect with Us Website: http://www.churchofphila.com  Twitter & Instagram:  Charlotte, NC: @churchofphilacha  Asbury Park, NJ: @churchofphilaap  Lakeland, Florida: @churchofphilalkld  Facebook:  Charlotte, NC: www.facebook.com/churchofphila  Asbury Park, NJ: www.facebook.com/churchofphilaap  Lakeland, Florida: www.facebook.com/churchofphilalkld

Dr. James Beckett: Sports Card Insights
1225 - Recap: Podcast Episodes 1201-1224

Dr. James Beckett: Sports Card Insights

Play Episode Listen Later May 24, 2024 13:55


Recapping and amplifying episodes 1201 to 1224. Overall, this recap presents a rich tapestry of topics, from the evolution of sports card collecting, market dynamics, historical perspectives, to personal growth stories within the hobby. 00:28 Founder's Influence: The Half-Life of Leadership 02:43 The Debate on Card Restoration 05:19 Mount Rushmore 06:39 Exploring the 10X Factor in the Hobby 07:23 The Wall of Fame: A Deep Dive 08:38 Sensory Challenges and the Hobby 09:16 Baseball Card Hall of Fame Insights 10:43 Grading, Alteration, and Restoration: A Hot Topic 11:10 From Dirty Jobs to Hobby Insights 11:39 Topps Conference Outtakes and Industry Updates 12:03 Dueling Questions with Chris Sewell 12:42 Basketball Hypotheticals and Industry Power Dynamics

Sports Card Nation
Hobby Quick Hits Ep.179 Alteration Thoughts/Grading Tips

Sports Card Nation

Play Episode Listen Later May 20, 2024 28:13


I often get asked my thoughts on card alteration/restoration and also tips on grading so I put those topics and thoughts together on this episode. Also: *New Product Release Schedule *Hobby News Follow us on Social Media:  Website:https://www.sportscardnationpo....com https://linktr.ee/Sportscardna...   E-Mail us at:hobbyquickhits@gmail.com Become a supporter of this podcast: https://www.spreaker.com/podcast/sports-card-nation-podcast--4761791/support.

Dr. James Beckett: Sports Card Insights
1218 - Listener Questions on Grading, Alteration, and Restoration

Dr. James Beckett: Sports Card Insights

Play Episode Listen Later May 8, 2024 12:48


The dialogue begins with debunking the myth that card grading is a scam, illustrating the rigorous checks, balances, and competitive nature of grading companies. Dr. Beckett emphasizes the importance of trust in these companies and how a grading system's transparency, like BGS' Report Card and PSA's new grading notes, is appreciated by collectors. The conversation shifts to explore grading logistics, stressing that if collectors disagree with a grade, options are available to seek re-grading, reflecting on the relatively minor variations in grading outcomes among reputable companies. A poignant moment comes when evaluating cards becomes equated to non-prejudice, highlighting a story where the value of a card should be seen independently of its presenter, advocating for objectivity in card assessment. Unusual grading scenarios, such as the impact of 'hot dog juice' on a card's integrity and the occasional added "value" of pinholes in cards, are discussed. Beckett also draws parallels between art restoration principles and card restoration, arguing for the necessity of transparency and honesty about a card's condition to preserve collector trust, while anticipating future shifts in the hobby. 00:44 Debunking Grading Myths and Explaining the Process 01:38 Exploring Grading Logistics and Company Variations 03:16 Unique Cases: Hot Dog Juice and Pinholes 05:32 Restoration Ethics and the Art World Comparison

The Voncast Show
Ep. 217: No More Dead Friends Ft. James Evans

The Voncast Show

Play Episode Listen Later May 3, 2024 66:20


Von interviews James Evans, the host of the No More Dead Friends podcast, about his journey to sobriety. James discusses the feeling of relief and escape that substance abuse provided him, as well as the external factors that contributed to his addiction. James also talks about his experience in treatment and the importance of building a foundation in recovery. Both Von and James reflect on the challenges and rewards of maintaining sobriety. The conversation explores the importance of addiction recovery and the challenges faced by individuals in maintaining sobriety. The hosts discuss their personal experiences with addiction and the role of support systems, such as Narcotics Anonymous (NA), in their recovery journeys. They emphasize the need for education and understanding of addiction as a disease and the importance of treating it as such. The conversation also delves into the power of cognitive behavioral therapy in changing distorted thinking patterns and building self-worth. The hosts discuss the No More Dead Friends podcast and its mission to share stories of recovery and promote awareness about addiction.Chapters (00:00) Introduction and Background(08:50) James' Experience with Alteration and Medication(25:10) The Challenges and Rewards of Maintaining Sobriety(32:43) The Role of Support Systems(49:33) Introducing the No More Dead Friends PodcastNo More Dead Friends PodcastNo More Dead Friends EtsyNo More Dead Friends IGFollow Me on Social Media: https://www.instagram.com/thevoncastshow/ https://www.instagram.com/shibavon/  https://www.tiktok.com/@wowshibavonWebsite:iamvon.net

Faith Over Breakfast
#5018 The Trump Bible (God Bless America Bible)

Faith Over Breakfast

Play Episode Listen Later Apr 1, 2024 48:38


Pastors Andy and Eric chat about the ramifications of the ex-president, Donald Trump's latest endeavor to market Bibles. Their conversation covers the fusion of biblical teachings with foundational American documents, such as the Constitution. They express concern over the trend of individuals blending their personal beliefs with the Bible and subsequently branding God's word with their own names. This practice of altering sacred texts with personal interpretations troubles them deeply.Support the show"Faith Over Breakfast with Pastors Andy & Eric" is a weekly podcast where Pastors Andy and Eric come together over a imaginary delicious breakfast to talk about faith, food, sermons, culture, and more. In each episode, the pastors delve into thought-provoking topics and offer inspiring insights and practical guidance for those seeking to deepen their relationship with Jesus. With occasional guests joining the conversation, "Faith Over Breakfast with Pastors Andy & Eric" provides a unique perspective on what it means to live a life of faith in today's world. Whether you're a seasoned Christian or just starting on your faith journey, this podcast is the perfect companion for your morning routine. So join Pastors Andy and Eric each week as they explore the intersections of faith, food, and life over a delicious breakfast.Support:https://www.buzzsprout.com/97804/support

THE MAG BITTER TRUTH PODCAST
THE ALTERATION OF HUMANS TO KEEP US HERE

THE MAG BITTER TRUTH PODCAST

Play Episode Listen Later Mar 26, 2024 50:57


Magbittertruth.com --- Send in a voice message: https://podcasters.spotify.com/pod/show/mag-bitter-truth/message

Sermons - The Potter's House
He Buried More Than a Talent by Pastor Joe Campbell (2014) | LEADERSHIP MONDAY

Sermons - The Potter's House

Play Episode Listen Later Mar 25, 2024 41:17


Summary In this sermon, Pastor Campbell dissects the parable of the talents and the consequences of burying one's talent. He emphasizes that the talent belongs to God and it is a privilege to use it for His kingdom. Burying the talent alters one's perception of God and others, leading to justification and a temptation to invest in the world and flesh. We are challenged to keep our talents active and pursue their purpose in God's will. Chapters 00:00 Introduction and Sermon Announcement01:02 Appreciation for the Congregation01:36 The Parable of the Talents06:11 The Meaning of Burying the Talent09:05 Reasons for Burying the Talent12:00 The Privilege of Having a Talent15:42 The Talent Belongs to God20:05 The Consequences of Burying the Talent23:45 The Potential and Possibilities of the Talent26:18 Burying the Talent Alters Perception of God and Others29:26 The Dangers of Entitlement and Justification32:13 The Alteration of Vision and Future35:36 The Temptation to Invest in the World and Flesh36:23 The Importance of Keeping the Talent Active36:40 Conclusion and Prayer Takeaways The talent we have is a privilege and belongs to God. Burying our talent alters our perception of God and others. Justifying our decision to bury the talent leads to a temptation to invest in the world and flesh. We must keep our talents active and pursue our purpose in God's will. ⁠Find a CFM Church near you: https://cfmmap.org⁠⁠⁠⁠⁠ SUBSCRIBE TO PREMIUM: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Subscribe for only $2.99/month on Spotify⁠: https://podcasters.spotify.com/pod/show/taking-the-land/subscribe⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Subscribe for only $3/month on Supercast⁠: https://taking-the-land.supercast.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Subscribe for only $4.99/month on Apple Podcasts⁠: https://apple.co/3vy1s5b⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ --- We need five-star reviews! Tell the world what you think about this podcast at: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Apple Podcasts⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠: https://apple.co/3vy1s5b⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Podchaser⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠: https://www.podchaser.com/podcasts/taking-the-land-cfm-sermon-pod-43369⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ --- Visit our sponsors: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠***FEATURED*** Global Passport Express: Mention this ad to get a 10% discount on all services⁠: https://bit.ly/TTL-GPE⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Pastor Mike Ashcraft's Financial Services⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠: (310) 403-6471 ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠10% Discount Off First Order from Advanced Creative Design: advancedcreativedesign23@gmail.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠$100 Credit for Text In Church: https://bit.ly/TTL-TIC⁠⁠⁠

Authentic Biochemistry
Biochemical Mosaic I. The PA phosphatase c.6. Alteration of the TCA pathway intermediates and hypoxia/nutrient deficiency control HIF1α stability indirectly regulating IMM protein and lipid turnover.

Authentic Biochemistry

Play Episode Listen Later Feb 13, 2024 30:00


References Front. Oncol. 2017. 26 November.V.7. Oncogene. 2017 Mar 23; 36(12): 1607–1618. Schubert, F. 1819 Piano Quintet in A major, D. 667/ "Trout" https://youtu.be/syod5rkFdNY?si=5F3rexiou7dTifYg Hunter, R., Garcia , J. 1970 "Ripple" https://youtu.be/xofhZx9eWUQ?si=tpOAMzyW5qUy01P_ --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

On this episode of the Real Life Pharmacology podcast, I take a dive into the most common mechanisms of drug interactions. Below I list some of the common drug interactions seen in practice and how they work! Opposing Effects Many drugs will work on various receptors throughout the body. To use as an educational point, there is no better example to point to than the beta receptor. Beta-blockers are frequently used in clinical practice for their ability to lower blood pressure and slow the heart rate. Both of these beneficial actions are primarily achieved by blocking the effects of beta-1 receptors. Some beta-blockers have action on alternative beta receptors. Propranolol is one such beta-blocker that is classified as a non-selective beta-blockers. This means that in addition to the positive effects on beta-1 receptors, it can also have blocking effects on beta-2 receptors. The blockade of the beta-2 receptor by propranolol can also be life-changing. It can directly oppose beta-2 agonists like albuterol from having their beneficial effects of opening up the airway. Enzyme Inhibition Medication metabolism is arguably the largest and most clinically significant source for drug interactions. Medications that are primarily metabolized by enzymes in the liver can be greatly affected if we affect how those enzymes work. CYP3A4 is one of the most well studied and well-known enzymes that can impact hundreds to maybe even thousands of drugs. Apixaban is an oral anticoagulant that is broken down at least in part by CYP3A4. By using a CYP3A4 inhibitor like erythromycin, there is the potential to raise concentrations of apixaban. This could lead to a higher risk of bleeding. Enzyme Induction Carbamazepine is a drug that you must know. This drug is a potent enzyme inducer. This differs significantly from an enzyme inhibitor and will have the exact opposite clinical effect. Drugs that are inactivated by liver enzymes will be inactivated more quickly in a patient taking an enzyme inducer. Going back to our prior apixaban example above, carbamazepine can induce CYP3A4 and facilitate a more efficient and swifter breakdown of the drug. Bleeding will be less likely. The risk for treatment failure, usually in the form of a blot clot, will be more likely.  Here's more information from the past on carbamazepine. Alteration in Absorption Binding interactions can be consequential and are one of the most common types of drug interactions. Many medications have the potential to bind one another in the gut. This can lead to lower concentrations of a specific medication. Calcium and iron are two of the most common examples of medications that can bind other drugs. Alteration in Protein Binding By remembering that unbound drug is an active drug, you should appreciate the risk for protein binding alterations. A significant number of medications can bind proteins in the bloodstream. As this occurs, that drug is not freely available to create physiologic effects. When another medication is added that can also bind these proteins, this can displace other medications and increase the quantity of free drug in the bloodstream. This essentially allows for enhanced physiologic effects. Warfarin is a medication that is highly protein-bound. When another drug is added that can kick warfarin off of those protein binding sites, it can free up warfarin which will increase the likelihood of elevating the patient's INR and increase their bleed risk. Alteration in Renal Elimination Some drugs can alter the way other medications are eliminated through the kidney. Chlorthalidone, like all thiazide diuretics, has the potential to block the excretion of lithium from the kidney. This can lead to lithium toxicity. This type of interaction, while significant, is much less common than drug interactions involve the liver and CYP enzyme pathways.   Effects on Transporters One of the last types of drug interactions is the effe...

Corrosion Chronicles
Benefits and Challenges of Fiber-Reinforced Composites

Corrosion Chronicles

Play Episode Listen Later Feb 7, 2024 48:08


In this episode, industry veteran Dale Keeler, Associate Director at MTI, sits down with co-hosts Heather Allain and Marc Cook to discuss fiber-reinforced composites (FRP). The three chat about: fabrication methods; the types of fiber, resin and additives; differences in design standards and practices around the globe; how material properties used in design are determined and validated; inspection and life assessment techniques; flange design; and thermal shock.   Show notes Public bookstore – Guide for Repair and Alteration of FRP Equipment:  https://marketplace.mimeo.com/mtiglobal/product/e3fb7e600fb4423b9532394fd8e7ec7b   Members bookstore – Guide for Repair and Alteration of FRP Equipment: https://marketplace.mimeo.com/mtiglobalMEMBERS/product/1868c1a40bd94e05be701ab394d89498   Embedded RFID Sensor Technology https://www.mti-global.org/rfid-microsite/monitor-frp-vessel-integrity-with-rfid-sensors   Risk Based Inspection for FRP Tanks https://access.mti-global.org/record/562?ln=en   Global FRP Standards Comparative Report https://access.mti-global.org/record/337?ln=en   Accelerated Testing of FRP https://access.mti-global.org/record/78?ln=en   Corrosion Chronicles is hosted by Heather Allain and Marc Cook. Heather Allain is the Executive Director of Materials Technology Institute (MTI). She has been with the organization for 16 years and previously held an Associate Director position facilitating MTI's Project work. Before MTI, she worked as a Materials Engineer at DuPont for 15 years, and has a BS in Materials Engineering from Rice University. Marc Cook has a BS in Chemical Engineering from Purdue University and an MS in Material Engineering from NC State. He has worked for Dow for 26 years and at a contracting company in Cincinnati for 3 years. His current role at Dow is leading the Technical Services Team for Ceramics and Refractory at Dow and providing materials engineering support to Dow's Freeport, Texas site. Disclaimer: Marc Cook is an employee of Dow but is speaking purely in a personal capacity and is not talking about or recommending Dow products.   Corrosion Chronicles is produced by Association Briefings.

Blair Technique Podcast
Strategic Communication and Action Steps for Breaking Out in 2024 with Dr. Jeff Langmaid

Blair Technique Podcast

Play Episode Listen Later Feb 6, 2024 66:27


In this conversation, Dr. Jeff Langmaid, also known as the "evidence-based chiropractor", discusses the misconceptions about evidence-based chiropractic and the importance of niching down and identifying ideal patients. Check out his podcast here: https://www.theevidencebasedchiropractor.com/ Check out his website for more about VMA and AOMSI: https://www.theevidencebasedchiropractor.com/ Check out Dr. Jeff's IG here: https://www.instagram.com/evidencebasedchiropractor/ Takeaways Niching down and identifying ideal patients is crucial for chiropractors to attract and serve the right individuals. Clear and effective communication is essential in chiropractic care to ensure patients understand their treatment plans and feel reassured. Focusing on the benefits of chiropractic care, rather than technical details, helps patients understand the value of treatment. The use of imaging, such as Vertebral Motion Analysis (VMA) and Alteration of Motion Segment Integrity (AOMC), can provide objective data to guide clinical decision-making in chiropractic. Building robust reporting and making updates to software can be challenging due to FDA clearance. The future of evidence-based chiropractic involves building referral relationships and providing educational content. Building relationships with healthcare providers is crucial for expanding your practice. Taking action and getting results is key to overcoming obscurity and succeeding in practice. Chapters 00:00 Introduction and Misconceptions about Evidence-Based Chiropractic 01:42 Dr. Jeff Langmaid's Background and the Origins of Evidence-Based Chiropractor 04:43 The Importance of Niching Down and Identifying Ideal Patients 08:45 The Role of Communication in Chiropractic Care 11:02 The Importance of Positive Healthcare Experiences 16:13 The Challenges of Patient Education and Communication 19:19 Using Templates and Scripts to Guide Communication 20:45 Focusing on Benefits Rather Than Features in Chiropractic Care 22:15 Being Flexible in Patient Care and Treatment Plans 25:48 The Importance of Reassurance and Clear Communication in Chiropractic 29:03 VMA and AOMC: Imaging in Chiropractic 32:38 The Dichotomous Thinking about Imaging in Chiropractic 36:39 The Clinical Decision-Making Process and the Use of Imaging 40:37 The Value of Objectifying Data in Chiropractic Care 41:50 Building Robust Reporting and Challenges with FDA Clearance 46:09 The Future of Evidence-Based CHIRO 50:15 Building Relationships with Healthcare Providers 58:33 Taking Action and Getting Results

Acton Line
Connecting Family, Property, and Liberty

Acton Line

Play Episode Listen Later Jan 10, 2024 66:46


In this episode of Acton Line, Dylan Pahman, Acton research fellow and executive editor of the Journal of Markets & Morality, interviews Dr. Clara Piano, assistant professor of economics at Austin Peay State University, about her recent paper “Familial Liberty: Property and Family in Late Scholastic Thought,” presented at Acton's Third Annual Academic Colloquium. Their wide-ranging discussion addresses such questions as: What is the connection between family and property? What insights do late Scholastic theologians have for us today? What does modern “pro-family” policy get wrong?  Subscribe to our podcasts  Alejandro Chafuen, “Faith and Liberty: The Economic Thought of the Late Scholastics” Juan de Mariana, “A Treatise on the Alteration of Money” Frank H. Knight, “Ethics and Economic Reform, I: The Ethics of Liberalism” Acton Line, “Free Enterprise and the Common Good” Pope Leo XIII, “Rerum Novarum” Victor V. Claar and Angela K. Dills, “Claudia Goldin Is the Ideal Academic Researcher” 

The Unruly Muse
The Chill Vibe

The Unruly Muse

Play Episode Listen Later Nov 29, 2023 29:42


SONG 1: Roses on the Floor    by JVM with Dan ModaffPOEM 1: “The Landing” by Mark Sanders, published in bosque journal #8. www.bosquepress.com. Mark is the author of Conditions of Grace. https://sandersme1.wixsite.com/FICTION: excerpt from “The Surrogate,” a novel in progress by Lynn C. Miller, author most recently of The Lost Archive. www.lynncmiller.comFeed the Cat Break: “Funky Stroller” by JVMPOEM 2: “Pond Coat and Alteration” by Barbara Rockman, author of most recently To Cleave. Poem published in bosque journal #8. www.bosquepress.comSONG 2: You Don't Love Me   by Dave Merrill with The DelversEpisode artwork by Lynda Miller Show theme and incidental music by John V. Modaff, BMI Recorded in Albuquerque, NM and Morehead, KY Produced at The Creek Studio, MoreheadNEXT UP on Episode 33:  At What Price Money?       

Politics Done Right
Activism at work in Kim Ogg admonishment rally. Bernie prevents physical alteration

Politics Done Right

Play Episode Listen Later Nov 15, 2023 58:07


Two activists admonish Kim Ogg for what many consider her dereliction of duty at the Harris County District Attorney's office. Sean Teare, her primary opponent had much to say as well. --- Send in a voice message: https://podcasters.spotify.com/pod/show/politicsdoneright/message Support this podcast: https://podcasters.spotify.com/pod/show/politicsdoneright/support

Forbidden Knowledge News
FKN Classics: Gray Lady Winked - NY Times History Alteration - Media Deception | Ashley Rindsberg

Forbidden Knowledge News

Play Episode Listen Later Nov 10, 2023 59:34


Watch The Forbidden Documentary tonight on Rokfin! https://rokfin.com/stream/40985/The-Forbidden-Documentary-Occult-Louisiana-Download the full length feature film!The Forbidden Documentary!!https://www.buymeacoffee.com/forbiddendoc/e/179799pThe Forbidden Documentary Episode 1 Official Trailerhttps://youtu.be/rpETzqdOf0cGet Cory Hughes Book!https://www.buymeacoffee.com/jfkbookhttps://www.amazon.com/Warning-History-Cory-Hughes/dp/B0CL14VQY6/ref=mp_s_a_1_1?crid=72HEFZQA7TAP&keywords=a+warning+from+history+cory+hughes&qid=1698861279&sprefix=a+warning+fro%2Caps%2C121&sr=8-1FKN Link Treehttps://linktr.ee/ForbiddenKnowledgeNewsMake a Donation to Forbidden Knowledge News http://supportfkn.comhttps://www.paypal.me/forbiddenknowledgeneForbidden Knowledge Network https://forbiddenknowledge.news/Get your medicinal mushroom supplies here!!https://berthoudfarm.com/sporeswaps.com/vendors/bf-geneticsGet 15% off your order from Nutronics Labs!https://www.nutronicslabs.com/discount/FKN?redirect=%2F%3Fafmc%3DFKN%26utm_campaign%3DFKN%26utm_source%3Dleaddyno%26utm_medium%3DaffiliateOr use code FKN C60 PurplePowerhttps://go.shopc60.com/FORBIDDEN10/ or use coupon code knowledge10Sign up on Rokfin!https://rokfin.com/fknplusFKN ON Rumblehttps://rumble.com/c/FKNSign up for The Big Fat Challenge!https://bit.ly/fkn-food-conspiracyBG Casthttps://rumble.com/user/BGcasthttps://www.spreaker.com/show/bgcastYouTube https://youtube.com/@fknclipsWatch The Food Conspiracy Now!https://bit.ly/fkn-food-conspiracySign up for Paranormality Magazine here!https://paranormalitymag.com?ref=1281Coupon code: FKNBecome Self-Sufficient With A Food Forest!!https://foodforestabundance.com/get-started/?ref=CHRISTOPHERMATHUse coupon code: FORBIDDEN for discountsThe FKN Store!https://www.fknstore.net/Our Facebook pageshttps://www.facebook.com/forbiddenknowledgenewsconspiracy/https://www.facebook.com/FKNNetwork/Instagram @forbiddenknowledgenews1@forbiddenknowledgenetworkTwitterhttps://twitter.com/ForbiddenKnow10?t=7qMVcdKGyWH_QiyTTYsG8Q&s=09email meforbiddenknowledgenews@gmail.comForbidden Knowledge News is also available on all popular podcast platforms!some music thanks to:https://www.bensound.com/This show is part of the Spreaker Prime Network, if you are interested in advertising on this podcast, contact us at https://www.spreaker.com/show/3589233/advertisement

Forbidden Knowledge News
FKN Classics: Alteration of Humanity - Transhuman Agenda - False Alien Invasion | Jay Weidner

Forbidden Knowledge News

Play Episode Listen Later Nov 2, 2023 62:51


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The Reality Revolution Podcast
Q'uo - On DNA Alteration And The Pineal Gland

The Reality Revolution Podcast

Play Episode Listen Later Mar 19, 2023 54:51


Was there a time, or were there times, in human history in which non-human intelligences altered human DNA associated with the function of the pineal gland? If so, when, by whom, and for what purposes? Will Q'uo please advise methods or practices to train the mind and improve the function of the pineal gland through the Ajna Chakra? The ability to do work in consciousness, as the activation of intelligent energy, may at some point allow the entity to contact intelligent infinity and know, in full, the One Infinite Creator that exists within all beings. Thus, this is a program of personal evolution for each entity that will be unique for each entity. For each is a unique portion of the One Infinite Creator that exists within all things and all entities. This is the journey of perhaps numerous lifetimes. However, each entity on Earth at this time has been incarnated through the seniority by vibration, which suggests that there are very likely many who have made progress up through the lower three chakras, have opened the heart chakra, which is the way that graduation into the fourth density of love and understanding is accomplished. And some few who have become adept who have gone forward into the blue energy center or chakra so that they may become the Creator that has the outflow of energies that surrounds them and all around them, and may inspire them to further work on their own journeys. Then, there is the possibility of the act of moving into the indigo-ray energy center. Q'uo is a gathering of high density beings who are channeled by ll research. For more on Q'uo check out https://www.llresearch.org Posted with approval of ll research. Music Epidemic Sound and Mettaverse Music 

UMD NEWMAN CATHOLIC CAMPUS MINISTRY
10/30/22 Alteration or Transformation?

UMD NEWMAN CATHOLIC CAMPUS MINISTRY

Play Episode Listen Later Oct 29, 2022 21:13


Homily from the Thirty-first Sunday in Ordinary Time. Zacchaeus knew that he was a bad man. What he didn't know was if he could be different. Too many of us come to Jesus with the idea that He is willing to change us and change our lives. But what happens when we want Him to merely offer cosmetic changes and He wants to make structural changes? Mass Readings from October 30, 2022: Wisdom 11:22-12:2 Psalms 145:1-2, 8-11, 13-142 Thessalonians 1:11-2:2 Luke 19:1-10