Podcasts about Rationale

In this episode of the Hands-On, Hands-Off Podcast, Dr. Trenton Rehman sits down with Dr. Shane McClinton to discuss plantar heel pain and the role of physical therapy in both clinical outcomes and healthcare costs.Dr. McClinton walks through a series of studies stemming from his doctoral research, including a randomized clinical trial, a detailed case series, and a three-year cost-effectiveness analysis. Together, they explore how adding physical therapy to usual podiatry care impacts pain, function, quality of life, and long-term costs.Key themes include manual therapy, impairment-based exercise, proximal contributions to heel pain, interdisciplinary collaboration, and why plantar heel pain may deserve the same clinical mindset as low back pain.Key Takeaways (Listener-Facing)Plantar heel pain is a multidimensional condition with local and proximal contributors.Adding physical therapy to usual podiatry care improved outcomes and reduced costs over three years.Manual therapy and exercise were delivered pragmatically and tailored to impairments.Strengthening may be underutilized in plantar heel pain management.Collaboration between physical therapists and podiatrists benefits patients and reduces downstream burden.⏱️ TIMESTAMPED CHAPTERS (YouTube + Podcast)00:00 – Introduction to the episode and guest00:01 – Dr. Shane McClinton's background and research focus00:03 – Why plantar heel pain referrals to PT are low00:07 – Rationale for studying cost-effectiveness00:10 – Study design overview (RCT + pragmatic approach)00:15 – Description of podiatry-only vs podiatry + PT care00:17 – Inclusion and exclusion criteria00:22 – Case series: why eight different heel pain presentations00:26 – Manual therapy strategies used in the study00:30 – Clinical practice guidelines and decision-making00:32 – Pain mechanisms, education, and chronicity00:35 – Proximal vs local treatment decisions00:38 – Three-year cost-effectiveness results explained00:44 – Implications for referrals and collaboration00:48 – Final take-home message from Dr. McClinton

The crew checks in live from Rockefeller Center and quickly veers from Patreon housekeeping into Polymarket absurdities, restaurant closures, and the grim mechanics of auctioning off a closed kitchen. Jean details liquidating equipment (including a Rationale), while Dave unloads on bureaucracy, safety grounds left floating inside a brand-new Bosch oven, and the theoretical physics of jacking oven temps via PT1000 resistance sensors—plus reversible home steam-injection hacks that don't involve drilling holes.Quinn talks risotto-style oats and fresh milling, and Dave breaks down grain texture, grinder damage myths, and why oats are mushy compared to rice. Listener questions round things out with astringency in drinks beyond tannins (bitters, resins, aromatics), blood-sausage preferences across styles, and how phosphoric acid can anchor a cola-like, carbonated amaro build. Hosted on Acast. See acast.com/privacy for more information.

Picture this: a patient with early-stage breast cancer is sitting in front of you in the clinic. You are about to offer your expert management plan. The age-old question arises—should you really perform a sentinel lymph node biopsy, or could omission actually help this patient more? Today, we're tackling one of the hottest debates in modern breast cancer care.Should we rethink sentinel lymph node biopsy for select patients, and can skipping it actually improve quality of life without sacrificing cancer control? The stakes couldn't be higher—balancing accurate cancer staging and minimizing harm is the name of the game. Together, we're breaking down the latest evidence from the SOUND and INSEMA trials. What do these landmark studies mean for your patients, your practice, and the future of axillary management? Ready for a journal review that might just change your next consult? Hosts:- Rashmi Kumar, MD, PhDResident, University of Michigan General Surgery Residency ProgramTwitter/X: @RashmiJKumar- Melissa Pilewskie, MDAttending Breast Surgical Oncologist, Co-Director of the Weiser Family Center for Breast Cancer, Michigan Medicine Twitter/X: @MPilewskie- Stephanie Downs-Canner, MDAttending Breast Surgical Oncologist & Physician-Scientist, Memorial Sloan Kettering Cancer Center, Program Director of the Breast Surgical Oncology Fellowship Training Program Twitter/X: @SDownsCannerLearning Objectives:- Understand when and for whom it is safe and beneficial to omit sentinel lymph node biopsy (SLNB) in early-stage breast cancer patients.- Identify the risks associated with foregoing SLNB, including loss of nodal staging, and analyze how this impacts treatment selection and prognosis.- Review key findings from the SOUND and INSEMA trials and their influence on axillary management.- Discuss implications for adjuvant therapy, genomic profiling, and multidisciplinary clinical practice.- Recognize which patient populations should still receive SLNB, and the importance of individualized, multidisciplinary decision-making.References:- Gentilini OD, Botteri E, Sangalli C, et al. Sentinel Lymph Node Biopsy vs No Axillary Surgery in Patients With Small Breast Cancer and Negative Results on Ultrasonography of Axillary Lymph Nodes: The SOUND Randomized Clinical Trial. JAMA Oncol. 2023;9(11):1557–1564. doi:10.1001/jamaoncol.2023.3759 https://pubmed.ncbi.nlm.nih.gov/37733364/- Reimer T, Stachs A, Veselinovic K, et al. Axillary surgery in breast cancer – primary results of the INSEMA trial. N Eng J Med. 2024. doi:10.1056/NEJMoa2412063.https://pubmed.ncbi.nlm.nih.gov/39665649/- Sparano JA, Gray RJ, Makower DF, Albain KS, Saphner TJ, Badve SS, Wagner LI, Kaklamani VG, Keane MM, Gomez HL, Reddy PS, Goggins TF, Mayer IA, Toppmeyer DL, Brufsky AM, Goetz MP, Berenberg JL, Mahalcioiu C, Desbiens C, Hayes DF, Dees EC, Geyer CE Jr, Olson JA Jr, Wood WC, Lively T, Paik S, Ellis MJ, Abrams J, Sledge GW Jr. Clinical Outcomes in Early Breast Cancer With a High 21-Gene Recurrence Score of 26 to 100 Assigned to Adjuvant Chemotherapy Plus Endocrine Therapy: A Secondary Analysis of the TAILORx Randomized Clinical Trial. JAMA Oncol. 2020 Mar 1;6(3):367-374. doi: 10.1001/jamaoncol.2019.4794. PMID: 31566680; PMCID: PMC6777230. https://pubmed.ncbi.nlm.nih.gov/31566680/- Slamon DJ, Fasching PA, Hurvitz S, Chia S, Crown J, Martín M, Barrios CH, Bardia A, Im SA, Yardley DA, Untch M, Huang CS, Stroyakovskiy D, Xu B, Moroose RL, Loi S, Visco F, Bee-Munteanu V, Afenjar K, Fresco R, Taran T, Chakravartty A, Zarate JP, Lteif A, Hortobagyi GN. Rationale and trial design of NATALEE: a Phase III trial of adjuvant ribociclib + endocrine therapy versus endocrine therapy alone in patients with HR+/HER2- early breast cancer. Ther Adv Med Oncol. 2023 May 29;15:17588359231178125. doi: 10.1177/17588359231178125. Erratum in: Ther Adv Med Oncol. 2023 Sep 29;15:17588359231201818. doi: 10.1177/17588359231201818. PMID: 37275963; PMCID: PMC10233570. https://pubmed.ncbi.nlm.nih.gov/37275963/Sponsor Disclosure: Visit goremedical.com/btkpod to learn more about GORE® SYNECOR Biomaterial, including supporting references and disclaimers for the presented content. Refer to Instructions for Use at eifu.goremedical.com for a complete description of all applicable indications, warnings, precautions and contraindications for the markets where this product is available. Rx only Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more.  If you liked this episode, check out our recent episodes here: https://behindtheknife.org/listenBehind the Knife Premium:General Surgery Oral Board Review Course: https://behindtheknife.org/premium/general-surgery-oral-board-reviewTrauma Surgery Video Atlas: https://behindtheknife.org/premium/trauma-surgery-video-atlasDominate Surgery: A High-Yield Guide to Your Surgery Clerkship: https://behindtheknife.org/premium/dominate-surgery-a-high-yield-guide-to-your-surgery-clerkshipDominate Surgery for APPs: A High-Yield Guide to Your Surgery Rotation: https://behindtheknife.org/premium/dominate-surgery-for-apps-a-high-yield-guide-to-your-surgery-rotationVascular Surgery Oral Board Review Course: https://behindtheknife.org/premium/vascular-surgery-oral-board-audio-reviewColorectal Surgery Oral Board Review Course: https://behindtheknife.org/premium/colorectal-surgery-oral-board-audio-reviewSurgical Oncology Oral Board Review Course: https://behindtheknife.org/premium/surgical-oncology-oral-board-audio-reviewCardiothoracic Oral Board Review Course: https://behindtheknife.org/premium/cardiothoracic-surgery-oral-board-audio-reviewDownload our App:Apple App Store: https://apps.apple.com/us/app/behind-the-knife/id1672420049Android/Google Play: https://play.google.com/store/apps/details?id=com.btk.app&hl=en_US

In this episode, I'm joined by Virginie Raphael — investor, entrepreneur, and philosopher of work — for a wide-ranging conversation about incentives, technology, and how we build systems that scale without losing their humanity. We talk about her background growing up around her family's flower business, and how those early experiences shaped the way she thinks about labor, value, and operating in the real economy. That foundation carries through to her work as an investor, where she brings an operator's lens to evaluating businesses and ideas. We explore how incentives quietly shape outcomes across industries, especially in healthcare. Virginie shares why telehealth was a meaningful shift and what needs to change to move beyond one-to-one, supply-constrained models of care. We also dig into AI, venture capital, and the mistakes founders commonly make today — from hiring sales teams too early to raising too much money too fast. Virginie offers candid advice on pitching investors, why thoughtful cold outreach still works, and how doing real research signals respect and fit. The conversation closes with a contrarian take on selling: why it's not a numbers game, how focus and pre-qualification drive better outcomes, and why knowing who not to target is just as valuable as finding the right people. If you're thinking about the future of work, building with intention, or navigating entrepreneurship in an AI-accelerated world, this episode is for you. And for more conversations like this, join us at Snafu Conference 2026 on March 5th, where we'll keep exploring incentives, human skills, and what it really takes to build things that last. Start (0:00) Reflections on Work, Geography, and AI Adoption Virginie shares what she's noticing as trends in work and tech adoption: Geographic focus: she's excited to explore AI adoption outside traditional tech hubs. Examples: Atlanta, Nashville, Durham, Utah, Colorado, Georgia, North Carolina, parts of the Midwest. Rationale: businesses in these regions may adopt AI faster due to budgets, urgency, and impatience for tech that doesn't perform. "There are big corporates, there are middle and small businesses in those geos that have budget that will need the tech… and/or have less patience, I should say, for over-hub technologies that don't work." She notes that transitions to transformational technology never happen overnight, which creates opportunities: "We always underestimate how much time a transition to making anything that's so transformational… truly ubiquitous… just tends to think that it will happen overnight and it never does." Robin adds context from her own experience with Robin's Cafe and San Francisco's Mission District: Observed cultural and business momentum tied to geography Mentions Hollywood decline and rise of alternative media hubs (Atlanta, Morocco, New Jersey) Virginie reflects on COVID's impact on workforce behaviors: Opened a "window" to new modes of work and accelerated change: "There were many preexisting trends… but I do think that COVID gave a bit of a window into what was possible." Emphasis on structural change: workforce shifts require multi-year perspective and infrastructure, not just trends. Investor, Mission, and Capital Philosophy Virginie clarifies she is an investor, not a venture capitalist, resisting labels and prestige metrics. "I don't call myself a venture capitalist… I just say investor." Focuses on outcomes over categories, investing in solutions that advance the world she wants to see rather than chasing trendy tech sectors. "The outcome we want to see is everyone having the mode of work that suits them best throughout their lives." Portfolio themes: Access: helping people discover jobs they wouldn't otherwise know about. Retention / support: preventing workforce dropouts, providing appropriate healthcare, childcare, and caregiving support. "Anyone anywhere building towards that vision is investible by us." Critiques traditional venture capital practices: Raising VC money is not inherently a sign of success. "Raising from a VC is just not a sign of success. It's a milestone, not the goal." Concerned about concentration of capital into a few funds, leaving many founders unsupported. "There's a sense… that the work we do commands a lot less power in the world, a lot less effectiveness than holding the capital to hire that labor." Emphasizes structural, mission-driven investing over chasing categories: Invests in companies that prevent workforce dropouts, expand opportunity, and create equitable access to meaningful work. Portfolio strategy is diversified, focusing on infrastructure and long-term impact rather than quick wins. "We've tracked over time what type of founders and what type of solutions we attract and it's exactly the type of deal that we want to see." Reflects on COVID and societal trends as a lens for her investment thesis: "COVID gave a bit of a window into what was possible," highlighting alternative modes of work and talent distribution that are often overlooked. Labor, Ownership, and Durable Skills Virginie reframes the concept of labor, wages, and ownership: "The word labor in and of itself… is something we need to change." Interested in agency and ownership as investment opportunities, especially for small businesses transitioning to employee ownership. "For a very long time… there's been a shift towards knowledge work and how those people are compensated. If you go on the blue-collar side… it's about wages still and labor." Emphasizes proper capitalization and alignment of funds to support meaningful exits for smaller businesses, rather than chasing massive exits that drive the VC zeitgeist. AI fits into this discussion as part of broader investment considerations. Childhood experience in family flower business shaped her entrepreneurial and labor perspective: Selling flowers, handling cash, and interacting with customers taught "durable skills" that persisted into adulthood. "When I think of labor, I think of literally planting pumpkin plants… pulling espresso shots… bringing a customer behind the counter." Observing her father start a business from scratch instilled risk-taking and entrepreneurial spirit. "Seeing my dad do this when I was seven… definitely part of that." Skills like sales acumen, handling money, and talking to adults were early lessons that translated into professional confidence. Non-linear career paths and expanding exposure to opportunity: Concerned that students often see only a narrow range of job options: "Kids go out of high school, they can think of three jobs, two of which are their parents' jobs… Surely because we do a poor job exposing them to other things." Advocates for creating more flexible and exploratory career pathways for young people and adults alike. Durable skills and language shaping work: Introduction of the term "durable skills" reframes how competencies are understood: "I use it all the time now… as a proof point for why we need to change language." Highlights the stigma and limitations of words like "soft skills" or "fractional work": Fractional roles are high-impact and intentional, not temporary or inferior. "Brilliant people who wanna work on a fractional basis… they truly wanna work differently… on a portfolio of things they're particularly good at solving." Work in Progress uses language intentionally to shift perceptions and empower people around work. Cultural significance of language in understanding work and people: Virginie notes that language carries stigma and meaning that shapes opportunities and perception. References Louis Thomas's essays as inspiration for attention to the nuance and power of words: He'll take the word discipline and distill it into its root, tie it back into the natural world." Robin shares a personal anecdote about language and culture: "You can always use Google Translate… but also it's somebody learning DIA or trying to learn dharia, which is Moroccan Arabic… because my fiance is Moroccan." Human-Positive AI, Process, and Apprenticeship Virginie emphasizes the value of process over pure efficiency, especially in investing and work: "It's not about the outcome often, it's about the process… there is truly an apprenticeship quality to venture and investing." Using AI to accelerate tasks like investment memos is possible, but the human learning and iterative discussion is critical: "There's some beauty in that inefficiency, that I think we ought not to lose." AI should augment human work rather than replace the nuanced judgment, particularly in roles requiring creativity, judgment, and relationship-building: "No individual should be in a job that's either unsafe or totally boring or a hundred percent automatable." Introduces the term "human-positive AI" to highlight tools that enhance human potential rather than simply automate tasks: "How do we use it to truly augment the work that we do and augment the people?" Project selection and learning as a metric of value: Virginie evaluates opportunities not just on outcome, but what she will learn and who she becomes by doing the work: "If this project were to fail, what would I still learn? What would I still get out of it?" Cites examples like running a one-day SNAFU conference to engage people in human-centered selling principles: "Who do I become as a result of doing that is always been much more important to me than the concrete outcomes of this thing going well." AI Bubble, Transition, and Opportunity Discusses the current AI landscape and the comparison to past tech bubbles: "I think we're in an AI bubble… 1999 was a tech bubble and Amazon grew out of it." Differentiates between speculative hype and foundational technological transformation: "It is fundamental. It is foundational. It is transformative. There's no question about that." Highlights the lag between technological introduction and widespread adoption: "There's always a pendulum swing… it takes time for massively transformative technology to fully integrate." AI as an enabler, not a replacement: Transition periods create opportunity for investment and human-positive augmentation. Examples from healthcare illustrate AI's potential when applied correctly: "We need other people to care for other people. Should we leverage AI so the doctor doesn't have to face away from the patient taking notes? Yes, ambient scribing is wonderful." Emphasizes building AI around real human use cases and avoiding over-automation: "What are the true use cases for it that make a ton of sense versus the ones we need to stay away from?" History and parallels with autonomous vehicles illustrate the delay between hype and full implementation: Lyft/Uber example: companies predicted autonomous vehicles as cost drivers; the transition opened up gig work: "I was a gig worker long before that was a term… the conversation around benefits and portability is still ongoing." AI will similarly require time to stabilize and integrate into workflows while creating new jobs. Bias, Structural Challenges, and Real-World AI Experiments Discusses the importance of addressing systemic bias in AI and tech: Shares the LinkedIn "#WearThePants" experiment: women altered gender identifiers to measure algorithmic reach: "They changed their picture, in some cases changed their names… and got much more massive reach." Demonstrates that AI can perpetuate structural biases baked into systems and historical behavior: "It's not just about building AI that's unbiased; it's about understanding what the algorithm might learn from centuries of entrenched behavior." Highlights the ongoing challenge of designing AI to avoid reinforcing existing inequities: "Now you understand the deeply structural ingrained issues we need to solve to not continue to compound what is already massively problematic." Parenting, Durable Skills, and Resilience Focus on instilling adaptability and problem-solving in children: "I refuse to problem solve for them. If they forget their homework, they figure it out, they email the teacher, they apologize the next day. I don't care. I don't help them." Emphasizes allowing children to navigate consequences themselves to build independence: "If he forgets his flute, he forgets his flute. I am not making the extra trip to school to bring him his flute." Everyday activities are opportunities to cultivate soft skills and confidence: "I let them order themselves at the restaurant… they need to look the waiter in the eye and order themselves… you need to speak more clearly or speak loudly." Cultural context and exposure shape learning: Practices like family meals without devices help children appreciate attention, respect, and communication: "No iPad or iPhone on our table… we sit properly, enjoy a meal together, and talk about things." Travel and cultural exposure are part of teaching adaptability and perspective: "We spent some time in France over the summer… the mindset they get from that is that meals matter, and people operate differently." Respecting individuality while fostering independence: "They are their own people and you need to respect that and step away… give them the ability to figure out who they are and what they like to do." Parenting as a balance of guidance and autonomy: "Feel like that was a handbook that you just offered for parenting or for management? Either one. Nobody prepares you for that… part of figuring out." Future of Work and Technology Horizons Timeframes for predicting trends: Focus on a 5-year horizon as a middle ground between short-term unpredictability and long-term uncertainty: "Five years feels like this middle zone that I'm kind of guessing in the haze, but I can kind of see some odd shapes." Short-term (6–18 months) is more precise; long-term (10–15 years) is harder to anticipate: "I'm a breezy investor. Six months at a time max… deal making between two people still matters in 18 months." Identifying emerging technologies with latent potential: Invests in technologies that are ready for massive impact but haven't yet had a "moment": "I like to look at technologies that have yet to have a moment… the combo of VR and AI is prime." Example: Skill Maker, a VR+AI training platform for auto technicians, addressing both a labor shortage and outdated certification processes: "We are short 650,000 auto technicians… if you can train a technician closer to a month or two versus two years, I promise you the auto shops are all over you." Focuses on alignment of incentives, business model innovation, and meaningful outcomes: "You train people faster, even expert technicians can benefit… earn more money… right, not as meaningful to them and not as profitable otherwise." Principles guiding technology and investment choices: Solving enduring problems rather than temporary fads: "What is a problem that is still not going to go away within the next 10–15 years?" Ensuring impact at scale while creating economic and personal value for participants: "Can make a huge difference in the lives of 650,000 people who would then have good paying jobs." Scaling, Incentives, and Opportunity Re-examining traditional practices and identifying opportunities for change: "If you've done a very specific thing the exact same way, at some point, that's prime to change." Telehealth is an example: while helpful for remote access, it hasn't fundamentally created capacity: "You're still in that one-to-one patient's relationship and an hour of your time with a provider is still an hour at a time." Next version of telehealth should aim to scale care beyond individual constraints: "Where do we take telehealth next… what is the next version of that that enables you to truly scale and change?" Incentives shape outcomes: "Thinking through that and all the incentives… if I were to change the incentives, then people would behave differently? The answer very often is yes, indeed." Paraphrasing Charlie Munger: "Look for the incentives and I can tell you the outcome." Founders, Pitching, and Common Mistakes Pet peeves in founder pitches: Lack of research and generic outreach is a major turn-off: "I can really quickly tell if you have indeed spent a fraction of a minute on my site… dear sir, automatic junk. I won't even read the thing." Well-crafted, thoughtful cold inbound pitches get attention: "Take some time. A well crafted cold inbound will get my attention… you don't need to figure out an intro." Big mistakes entrepreneurs make: Hiring too early, especially in sales: "Until you have a playbook, like don't hire a sales team… if you don't have about a million in revenue, you're probably not ready." Raising too much capital too quickly: "You get into that, you're just gonna spend a lot more time fundraising than you are building a company." Comparing oneself to others: "You don't know if it's true… there's always a backstory… that overnight success was 15 years in the making." Sales Strategy and Non-Sales Selling Approach is contrarian: focus on conversion, not volume: "It is not a numbers game. I think it's a conversion game… I would much rather spend more time with a narrower set of targets and drive better conversion." Understanding fit is key: "You gotta find your people… and just finding who is not or should not be on your list is equally valuable." Recognizes that each fund and business is unique, so a tailored approach is essential: "The pitch is better when I'm talking to the quote unquote right people in the right place about the right things." Where to Find Virginie and Her Work Resources for listeners: Full Circle Fund: fullcirclefund.io  Work in Progress: workinprogress.io  LinkedIn: Virginie Raphael  Where to Access Snafu Go to joinsnafu.com and sign up for free.  

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-467 Overview: Join us as we discuss recent changes to newborn hepatitis B vaccination recommendations and review the risks, benefits, and rationale for immunizing this patient population. Come away with confidence to navigate new guidance, thoughtfully address parental concerns, and provide evidence-based care that promotes both infant and public health. Episode resource links: N Engl J Med 2019;380:2041-2050  DOI: 10.1056/NEJMra181047 Clin Infect Dis. 2021 Nov 2;73(9):e3317-e3323. doi: 10.1093/cid/ciaa898.  Guest: Robert A. Baldor MD, FAAFP   Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com  

From "clean beauty" fairy tales experts wish you’d forget to the marketing myths clogging your feed, today’s guest is stripping away the bullshit to reveal the cold, hard science of skin. On this week's episode of The Formula, content creator and evidence-based advocate Sam [By The Counter] breaks down why reading an ingredient list is like trying to guess a cake recipe without the measurements, the truth about who actually pays for "cruelty-free" research, and why your favourite luxury products might actually be worth the splurge. Plus, Sam explains why fragrance isn't the enemy, the "moral superiority" trap in sustainable packaging, and the indie products he swears by for a perfect barrier. PRODUCTS MENTIONED: build [skincare] b-cream, $30. Biologique Recherche Lotion P50, $260. Rationale #5 The Milk Concentrate, $214. DAB by Augustinus Bader Science Supercharged Glow Complex, $138. CHANEL SUBLIMAGE LA CRÈME TEXTURE SUPRÊME Ultimate Cream, $670. CHANEL COCO MADEMOISELLE Foaming Shower Gel, $215. The Eco Well (Jen Novakovic) Lab Muffin Beauty Science (Michelle Wong) FOR MORE WHERE THIS CAME FROM: Hosts: Kelly McCarren Guest: Sam [By The Counter] Producer: Sophie Campbell Audio Producer: Tegan Sadler Video Producer: Artemi Kokkaris Just so you know — some of the links in these notes are affiliate links, which means we might earn a small commission if you buy through them. It doesn’t cost you anything extra, and it helps support the show. Happy shopping! Mamamia acknowledges the Traditional Owners of the Land we have recorded this podcast on, the Gadigal people of the Eora Nation. We pay our respects to their Elders past and present, and extend that respect to all Aboriginal and Torres Strait Islander cultures.Become a Mamamia subscriber: https://www.mamamia.com.au/subscribeSee omnystudio.com/listener for privacy information.

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-467 Overview: Join us as we discuss recent changes to newborn hepatitis B vaccination recommendations and review the risks, benefits, and rationale for immunizing this patient population. Come away with confidence to navigate new guidance, thoughtfully address parental concerns, and provide evidence-based care that promotes both infant and public health. Episode resource links: N Engl J Med 2019;380:2041-2050  DOI: 10.1056/NEJMra181047 Clin Infect Dis. 2021 Nov 2;73(9):e3317-e3323. doi: 10.1093/cid/ciaa898.  Guest: Robert A. Baldor MD, FAAFP   Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com  

Welcome to the NeurologyLive® Mind Moments® podcast. Tune in to hear leaders in neurology sound off on topics that impact your clinical practice.In this episode, "Bexicaserin, the PACIFIC Trial, and Treating Developmental Epileptic Encephalopathies," Johannes Streffer, MD, PhD, discusses phase 1/2 findings from the PACIFIC trial evaluating bexicaserin in developmental epileptic encephalopathies, presented at the American Epilepsy Society 2025 Annual Meeting. Streffer, senior vice president of clinical development at Lundbeck, outlines the scientific and clinical rationale for studying DEEs as a unified population, emphasizing the unmet need and complexity of trial design in this highly vulnerable group. He reviews key efficacy outcomes, including sustained reductions in countable motor seizures and strong patient retention through long-term open-label extension and expanded access follow-up. The discussion also explores safety and tolerability considerations in patients receiving multiple concomitant antiseizure medications, the highly selective mechanism of action of bexicaserin, and how Lundbeck's broader strategy in rare neurological disorders aims to de-risk development early while addressing populations with limited therapeutic options.Looking for more Epilepsy discussion? Check out the NeurologyLive® Epilepsy clinical focus page.Episode Breakdown: 1:05 – Rationale for studying developmental epileptic encephalopathies as a unified group 3:05 – Challenges of trial design and retention in vulnerable pediatric DEE populations 5:25 – Key PACIFIC efficacy findings and long-term open-label extension results 7:05 – Neurology News Minute 9:15 – Safety, tolerability, and drug-drug interaction considerations for bexicaserin 11:20 – Lundbeck's strategy across rare and severe neurological disorders The stories featured in this week's Neurology News Minute, which will give you quick updates on the following developments in neurology, are further detailed here: Remyelinating Agent PIPE-307 Falls Short in Phase 2 Trial of Relapsing Multiple Sclerosis Semaglutide Linked to Improved Neurological Outcomes in Large Vessel Occlusion Without IV Thrombolysis FDA Approves Generic Glatiramer Acetate Injection for Multiple Sclerosis Treatment Thanks for listening to the NeurologyLive® Mind Moments® podcast. To support the show, be sure to rate, review, and subscribe wherever you listen to podcasts. For more neurology news and expert-driven content, visit neurologylive.com.

Rebecca Dent, MD, FRCP (Canada) - TROP2 and Triple-Negative Breast Cancer: The Rationale and Emerging Evidence for Exploring the Therapeutic Potential of TROP2-Targeted Antibody-Drug Conjugates in Earlier Lines and Disease-Stage Settings

Hour 2 of the WIP Afternoon Show dives into Nick Sirianni's rationale for resting the starters vs. the Commanders, with former Eagles head coach Dick Vermeil sharing his take on the controversial move.

Democracy in the UK is under strain. Many voters feel deeply alienated from politics, believing that those elected to represent them often pursue narrow or personal interests rather than the public good. Political polarisation, intensified by changes in the media landscape, is undermining constructive debate. And for many citizens, it can feel as though money (rather than votes) is what really speaks loudest in politics.Against this backdrop, there is growing interest in how democratic systems might be reformed to function better and become more resilient. A wide range of proposals has emerged, tackling different aspects of democratic decline. While we can't cover them all in a single episode, today's discussion focuses on two specific reform ideas explored in recent articles published in the journal The Political Quarterly.The first examines the role of donations to political parties, asking how political finance shapes power, influence, and public trust in the democratic system. The second looks at the position of smaller parties in the House of Commons, exploring how parliamentary procedures affect their ability to contribute meaningfully to debate and scrutiny.To discuss these ideas, we're joined by the authors of both pieces:Iain McMenamin, Professor of Comparative Politics at Dublin City University, is an expert on political finance and co-author of the article on party donations.Louise Thompson, Senior Lecturer in Politics at the University of Manchester, is a leading scholar of parliamentary politics and the author of the study on the role of small parties in the Commons.Together, we explore whether reforming party funding and giving smaller parties a stronger voice in Parliament could help rebuild trust, improve representation, and strengthen UK democracy.Mentioned in this episode:‘Unbroken, but Dangerous: The UK's Political Finance Regime and the Rationale for Reform', by Logan De la Torre, Kevin Fahey, and Iain McMenamin 'Modernising the House: Why the 2024 Parliament Highlights the Need to Formalise Party-Group Rights in the House of Commons', by Louise Thompson.  UCL's Department of Political Science and School of Public Policy offers a uniquely stimulating environment for the study of all fields of politics, including international relations, political theory, human rights, public policy-making and administration. The Department is recognised for its world-class research and policy impact, ranking among the top departments in the UK on both the 2021 Research Excellence Framework and the latest Guardian rankings.

Die Existenz Gottes kann mittels philosophischer Argumente bewiesen werden. So war die verbreitete Vorstellung im Mittelalter. In den letzten zwei Jahrhunderten kam sie aus der Mode. Ändern möchte das der katholische Philosoph Sebastian Ostritsch. Ostritsch, Sebastian; Newmark, Catherine www.deutschlandfunkkultur.de, Sein und Streit

(00:00) - Introduction(03:22) - Rationale for the Policy(04:40) - Glasgow City Council's Evidence(06:45) - Emissions & Air Quality(10:23) - Piecemeal Approach to Implementation(11:37) - Concerns of Businesses & Residents(16:19) - Using Revenue Raised

Chegou o episódio escolhido por vocês! Marcela Belleza e Joanne Alves convidam Carol Millon para conversar sobe 6 clinicagens de inibidores de SGLT2, as gliflozinas:Indicações além do DMRisco de CAD euglicêmicaQuando não usar?⁠Cuidados com doença aguda (sick day) e hipovolemia⁠Cuidados pré-operatórioRisco de fratura e amputaçãoReferências:1. Bailey CJ, et al. Dapagliflozin add-on to metformin in type 2 diabetes inadequately controlled with metformin: a randomized, double-blind, placebo-controlled 102-week trial. BMC Med. 2013;11:43. Published 2013 Feb 20. doi:10.1186/1741-7015-11-432. Bersoff-Matcha SJ, et al. Fournier Gangrene Associated With Sodium-Glucose Cotransporter-2 Inhibitors: A Review of Spontaneous Postmarketing Cases. Ann Intern Med. 2019;170(11):764-769. doi:10.7326/M19-00853. Chang HY, et al. Association Between Sodium-Glucose Cotransporter 2 Inhibitors and Lower Extremity Amputation Among Patients With Type 2 Diabetes. JAMA Intern Med. 2018;178(9):1190-1198. doi:10.1001/jamainternmed.2018.3034 4. Clar C, et al. Systematic review of SGLT2 receptor inhibitors in dual or triple therapy in type 2 diabetes. BMJ Open. 2012 Oct 18;2(5):e001007. doi: 10.1136/bmjopen-2012-001007. PMID: 23087012; PMCID: PMC3488745.5. Das SR, et al. 2020 Expert Consensus Decision Pathway on Novel Therapies for Cardiovascular Risk Reduction in Patients With Type 2 Diabetes: A Report of the American College of Cardiology Solution Set Oversight Committee. J Am Coll Cardiol. 2020 Sep 1;76(9):1117-1145. doi: 10.1016/j.jacc.2020.05.037. Epub 2020 Aug 5. PMID: 32771263; PMCID: PMC7545583. 6. Fralick M, et al. Risk of amputation with canagliflozin across categories of age and cardiovascular risk in three US nationwide databases: cohort study. BMJ. 2020;370:m2812. Published 2020 Aug 25. doi:10.1136/bmj.m28127. Li D, et al. Urinary tract and genital infections in patients with type 2 diabetes treated with sodium-glucose co-transporter 2 inhibitors: A meta-analysis of randomized controlled trials. Diabetes Obes Metab. 2017;19(3):348-355. doi:10.1111/dom.128258. Neal B, et al. Rationale, design, and baseline characteristics of the Canagliflozin Cardiovascular Assessment Study (CANVAS)--a randomized placebo-controlled trial. Am Heart J. 2013;166(2):217-223.e11. doi:10.1016/j.ahj.2013.05.0079. Nyirjesy P, et al. Evaluation of vulvovaginal symptoms and Candida colonization in women with type 2 diabetes mellitus treated with canagliflozin, a sodium glucose co-transporter 2 inhibitor. Curr Med Res Opin. 2012;28(7):1173-1178. doi:10.1185/03007995.2012.69705310. Perkovic V, et al. Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy. N Engl J Med. 2019;380(24):2295-2306. doi:10.1056/NEJMoa181174411. Rosenwasser RF, et al. SGLT-2 inhibitors and their potential in the treatment of diabetes. Diabetes Metab Syndr Obes. 2013 Nov 27;6:453-67. doi: 10.2147/DMSO.S34416. PMID: 24348059; PMCID: PMC3848644.12. Sridharan K, Sivaramakrishnan G. Risk of limb amputation and bone fractures with sodium glucose cotransporter-2 inhibitors: a network meta-analysis and meta-regression. Expert Opin Drug Saf. 2025;24(7):797-804. doi:10.1080/14740338.2024.237775513. Ueda P,  et al. Sodium glucose cotransporter 2 inhibitors and risk of serious adverse events: nationwide register based cohort study. BMJ. 2018;363:k4365. Published 2018 Nov 14. doi:10.1136/bmj.k436514. Watts NB, et al. Effects of Canagliflozin on Fracture Risk in Patients With Type 2 Diabetes Mellitus. J Clin Endocrinol Metab. 2016 Jan;101(1):157-66. doi: 10.1210/jc.2015-3167. Epub 2015 Nov 18. PMID: 26580237; PMCID: PMC4701850.15. Zhuo M, et al. Association of Sodium-Glucose Cotransporter-2 Inhibitors With Fracture Risk in Older Adults With Type 2 Diabetes. JAMA Netw Open. 2021;4(10):e2130762. Published 2021 Oct 1. doi:10.1001/jamanetworkopen.2021.3076216. Emerson Cestari Marino, Leandra Anália Freitas Negretto, Rogério Silicani Ribeiro, Denise Momesso, Alina Coutinho Rodrigues Feitosa, Marcos Tadashi Kakitani Toyoshima, Joaquim Custódio da Silva Junior, Sérgio Vencio, Marcio Weissheimer Lauria, João Roberto de Sá, Domingos A. Malerbi, Fernando Valente, Silmara A. O. Leite, Danillo Ewerton Oliveira Amaral, Gabriel Magalhães Nunes Guimarães, Plínio da Cunha Leal, Maristela Bueno Lopes, Luiz Carlos Bastos Salles, Liana Maria Torres de Araújo Azi, Amanda Gomes Fonseca, Lorena Ibiapina M. Carvalho, Francília Faloni Coelho, Bruno Halpern, Cynthia M. Valerio, Fabio R. Trujilho,  Antonio Carlos Aguiar Brandão, Ruy Lyra e Marcello Bertoluci. Rastreamento e Controle da Hiperglicemia no Perioperatório – Posicionamento Conjunto da Sociedade Brasileira de Diabetes (SBD), Sociedade Brasileira de Anestesiologia (SBA) e Associação Brasileira para o Estudo da Obesidade e Síndrome Metabólica (ABESO). Diretriz Oficial da Sociedade Brasileira de Diabetes (2025). DOI: 10.29327/5660187.2025-10 , ISBN: 978-65-5941-367-6.17. Singh LG, Ntelis S, Siddiqui T, Seliger SL, Sorkin JD, Spanakis EK. Association of Continued Use of SGLT2 Inhibitors From the Ambulatory to Inpatient Setting With Hospital Outcomes in Patients With Diabetes: A Nationwide Cohort Study. Diabetes Care. 2024;47(6):933-940. doi:10.2337/dc23-112918. Mehta PB, Robinson A, Burkhardt D, Rushakoff RJ. Inpatient Perioperative Euglycemic Diabetic Ketoacidosis Due to Sodium-Glucose Cotransporter-2 Inhibitors - Lessons From a Case Series and Strategies to Decrease Incidence. Endocr Pract. 2022;28(9):884-888. doi:10.1016/j.eprac.2022.06.00619. Umapathysivam MM, Morgan B, Inglis JM, et al. SGLT2 Inhibitor-Associated Ketoacidosis vs Type 1 Diabetes-Associated Ketoacidosis. JAMA Netw Open. 2024;7(3):e242744. Published 2024 Mar 4. doi:10.1001/jamanetworkopen.2024.274420. Fleming N, Hamblin PS, Story D, Ekinci EI. Evolving Evidence of Diabetic Ketoacidosis in Patients Taking Sodium-Glucose Cotransporter 2 Inhibitors. J Clin Endocrinol Metab. 2020;105(8):dgaa200. doi:10.1210/clinem/dgaa20021. Neuen BL, Young T, Heerspink HJL, et al. SGLT2 inhibitors for the prevention of kidney failure in patients with type 2 diabetes: a systematic review and meta-analysis. Lancet Diabetes Endocrinol. 2019;7(11):845-854. doi:10.1016/S2213-8587(19)30256-622. Braunwald E. Gliflozins in the Management of Cardiovascular Disease. N Engl J Med. 2022;386(21):2024-2034. doi:10.1056/NEJMra211501123. Zinman B, Wanner C, Lachin JM, et al. Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes. N Engl J Med. 2015;373(22):2117-2128. doi:10.1056/NEJMoa150472024. Neal B, Perkovic V, Mahaffey KW, et al. Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes. N Engl J Med. 2017;377(7):644-657. doi:10.1056/NEJMoa161192525. Wiviott SD, Raz I, Bonaca MP, et al. Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes. N Engl J Med. 2019;380(4):347-357. doi:10.1056/NEJMoa181238926. McMurray JJV, Solomon SD, Inzucchi SE, et al. Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction. N Engl J Med. 2019;381(21):1995-2008. doi:10.1056/NEJMoa191130327. Packer M, Anker SD, Butler J, et al. Cardiovascular and Renal Outcomes with Empagliflozin in Heart Failure. N Engl J Med. 2020;383(15):1413-1424. doi:10.1056/NEJMoa202219028. Anker SD, Butler J, Filippatos G, et al. Empagliflozin in Heart Failure with a Preserved Ejection Fraction. N Engl J Med. 2021;385(16):1451-1461. doi:10.1056/NEJMoa210703829. Heerspink HJL, Stefánsson BV, Correa-Rotter R, et al. Dapagliflozin in Patients with Chronic Kidney Disease. N Engl J Med. 2020;383(15):1436-1446. doi:10.1056/NEJMoa202481630. The EMPA-KIDNEY Collaborative Group, Herrington WG, Staplin N, et al. Empagliflozin in...

Should a nonprofit create its own foundation? The answer is surprisingly simple and at the same time, relentlessly hard: will it raise more money? Foundations only make sense when organizational complexity, donor access, privacy, or governance limitations are actively holding philanthropy back. Done well, a foundation creates focus, opens doors, and frees leadership to pursue deeper donor relationships. Done poorly (or too early) it adds cost, confusion, and duplication without impact.

US S&P futures slightly firmer but Nasdaq lower. European opened with modest gains and Asian's broadly higher. Bond yields mixed. US 10-year up 2 bps at 4.2%. Gilts off 1 bps at 4.5% after soft UK data. Dollar slightly firmer versus yen and sterling, softer elsewhere. Oil up. Gold edges higher. Industrial metals mixed. Bitcoin gains. Economists are aligning views with ECB Executive Board member Schnabel that next move in rates is likely to be a hike. Bloomberg survey of economists showed 60% of respondents think the ECB is more likely to raise rates than lower them, which is a meaningful shift from October when only a third shared that outlook. However, rate hikes will not likely come anytime soon with the majority expecting deposit rate to remain at 2% for the next two years. Rationale for extended period of unchanged policy is the improving macro backdrop.Companies Mentioned: Destination XL Group, Citigroup, Warner Bros. Discovery, Paramount Skydance

The U.S. is now highlighting its significant seizure of a Venezuelan oil tanker as part of a larger effort to fight drug trafficking, even as Venezuela describes the move as “piracy.” Plus, DHS Secretary Kristi Noem faced a heated hearing on Capitol Hill over immigration raids and FEMA's storm response. Critics are now calling for her resignation. And in Indiana, a political shockwave. Republican state senators teamed up with Democrats to sink a Trump-backed redistricting plan in a clear and very public break from the president. These stories and more highlight your Unbiased Updates for Friday, December 12, 2025.

The U.S. is now highlighting its significant seizure of a Venezuelan oil tanker as part of a larger effort to fight drug trafficking, even as Venezuela describes the move as “piracy.” Plus, DHS Secretary Kristi Noem faced a heated hearing on Capitol Hill over immigration raids and FEMA's storm response. Critics are now calling for her resignation. And in Indiana, a political shockwave. Republican state senators teamed up with Democrats to sink a Trump-backed redistricting plan in a clear and very public break from the president. These stories and more highlight your Unbiased Updates for Friday, December 12, 2025.

Mavericks TRADED Luka Doncic for THIS reason?!

Today on Truth in Politics and Culture, we will talk about the latest peace proposals for ending war in Ukraine. The US, Ukraine, and Europe are now on the same page, but will Putin get on board? The Trump Administration appears to be on the verge of invading Venezuela...what are some possible reasons for talking this bold action? Also, the GOP faces a tough challenge in a red district in Tennessee. A Republican victory is a must.

Are you up to date with the latest guidelines on deep venous thrombosis (DVT) management? Dr. Steven Abramowitz, vascular surgeon at MedStar Health, joins host Dr. Chris Beck for a deep dive into emerging clinical data in DVT management, where they review the evolving indications for mechanical thrombectomy and the implications of studies like the ATTRACT trial, the CLOUT registry, and the ongoing DEFIANCE trial. --- This podcast is supported by: Inari Medicalhttps://www.inarimedical.com/artix-system --- SYNPOSIS Dr. Abramowitz reviews recent data comparing outcomes of mechanical intervention versus lytic-based therapy, outlining how each approach fits into current practice. He underscores the critical role of IVUS in determining treatment endpoints, while noting the ongoing challenge of an absent standardized definition. The conversation also offers practical insights on procedural techniques and the evolving role of anticoagulation, emphasizing the importance of close collaboration and open communication with referring physicians. --- TIMESTAMPS 00:00 - Introduction00:45 - Overview of DVT Management02:50 - New Guidelines for DVT Treatment07:30 - Technical Endpoints in DVT Treatment13:26 - Clout Registry and Its Findings17:57 - Anticoagulation and DVT23:05 - Defining Acute DVT Management27:00 - Evolving Approaches to Acute DVT28:19 - Patient Experience and Quality of Life31:08 - Referring Providers and Data Impact37:01 - Single Session Treatments and Stenting41:07 - Chronic Venous Disease Management --- RESOURCES (ATTRACT) Weinberg I, Vedantham S, Salter A, et al. Relationships between the use of pharmacomechanical catheter-directed thrombolysis, sonographic findings, and clinical outcomes in patients with acute proximal DVT: Results from the ATTRACT Multicenter Randomized Trial. Vasc Med. 2019;24(5):442-451. doi:10.1177/1358863X19862043https://pubmed.ncbi.nlm.nih.gov/31354089/ (CLOUT) Shaikh A, Zybulewski A, Paulisin J, et al. Six-Month Outcomes of Mechanical Thrombectomy for Treating Deep Vein Thrombosis: Analysis from the 500-Patient CLOUT Registry. Cardiovasc Intervent Radiol. 2023;46(11):1571-1580. doi:10.1007/s00270-023-03509-8https://pubmed.ncbi.nlm.nih.gov/37580422/ (DEFIANCE) Abramowitz SD, Marko X, D'Souza D, et al. Rationale and design of the DEFIANCE study: A randomized controlled trial of mechanical thrombectomy versus anticoagulation alone for iliofemoral deep vein thrombosis. Am Heart J. 2025;281:92-102. doi:10.1016/j.ahj.2024.10.016https://pubmed.ncbi.nlm.nih.gov/39491572/

Wendy Pickett, Co-Founder & EVP of Sales, RationAle Brewing. Bringing 25 years of consumer goods experience to the non-alcoholic craft brewing brand, Wendy has a long history of building legacy brands in the grocery/mass, natural, and specialty channels. As one of the few female leaders in the male-dominated alcohol space, she's helping reshape the future of NA craft beer, tapping into the surging demand for NA options driven by wellness-minded consumers.what we chat about:RationAle's mission is to “crush society's drinking rules.” How do you see mindful drinking reshaping not just the NA beer industry, but drinking culture at large?As a woman co-founder in the beer industry—an industry historically dominated by men—what challenges and opportunities have you experienced in carving out space for both yourself and RationAle?The Crush the Crisis initiative ties RationAle directly to mental health and wellness. Can you share more about the impact of that program and why it was important to bake into the brand's DNA from the start?IG rationalebrewing.com | rationalebrewingFind Me:IG + TikTok citrusdiaries.studiocitrusdiaries.com | hello@citrusdiaries.comCreate your ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠podcast⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ today! ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠#madeonzencastr

We all know that huge sums of money are invested in creating new, more effective weapons of war.  Brian Abrams sees an opportunity to invest instead in what he calls "peace tech," emerging businesses using technologies and creative methods designed to prevent war from happening in the first place. He's created a new firm, B Ventures, and in this Blue Sky episode he describes with infectious optimism his exciting vision for the future.    Chapters: 00:00 Introduction to Brian Abrams  Bill Burke introduces Brian Abrams, founder of B Ventures Group, an investment fund focused on global peacebuilding and conflict resolution through "peace tech." Brian's extensive background in managing over $1 billion in assets and his human-centric investment philosophy are highlighted.  02:09 From Founder to Venture Capitalist  Brian shares his career journey, starting as an entrepreneur in India where he experienced failure, which led him to realize his strength in spotting opportunities rather than operationalizing them. He then transitioned to venture capital in Israel, building a fund from $2 million to over $1.2 billion, emphasizing the role of luck and a pivotal moment in fostering peace initiatives.  08:28 The Genesis of Peace Tech  Brian reflects on his past experiences, including a startup's condition to include Palestinian teammates during an acquisition, which planted the seed for his current work. He explains his philosophy of using money to serve people and approaching problems from a bottom-up perspective, leading him to focus on peace tech as an alternative to military tech.  10:17 The Rationale for Peace Tech  Drawing inspiration from Thich Nhat Hanh's philosophy of 'interbeing,' Brian articulates why war is illogical and a form of collective self-harm. He emphasizes the enormous economic cost of violent conflict, totaling $19 trillion annually, and how venture capital's bottom-up, experimental approach can offer innovative solutions for peacebuilding.  15:28 AI in Crisis Simulation  Brian describes an investment in a startup founded by a Harvard researcher who developed an AI-powered crisis simulation platform. This technology aims to anticipate and prevent future conflicts, like potential World War III over Taiwan, by running thousands of scenarios daily, far exceeding traditional war games.  21:32 Business Model for Peace Tech  Brian explains the twofold business model for peace tech startups: selling to friendly governments and to companies for competitive landscape analysis. He emphasizes that a for-profit model ensures scalability and continuous funding, unlike grants, allowing for exponential growth and a virtuous cycle to prevent major conflicts.  29:23 Peace Tech: Agile and Ethical  Brian highlights the agility of venture-backed peace tech companies compared to traditional government or academic initiatives, citing an example of a startup rapidly forming after the dismantling of the US Institute of Peace. He defines peace tech as anything that preempts, mitigates, or resolves violent conflict, adhering to a 'first do no harm' principle.  34:26 Peace Tech Investments and Ecosystem  Brian discusses additional investments, including a company creating digital twins of societies to understand and model civil conflicts like those between Armenia and Azerbaijan. He describes the growing Peace Tech ecosystem, drawing parallels to the private space industry's exponential growth, and aims to build a global community of founders and investors.  41:12 Conclusion and Call to Action  Bill Burke reflects on how technology's ability to show the grim reality of war might increase the fervent desire for peace. Brian encourages listeners to connect via LinkedIn and join the Peace Tech community, expressing his strong optimism for the future impact of this movement.   

Donnell Duncan, P.E., S.E. is the author of the revolutionary new book; Faith Science - "Where Faith and The Scientific Method Collide." While studying Applied Physics in 2000, he did research on the Cosmic Microwave Background, an important aspect of The Big Bang Theory at the Lawrence Berkeley National Laboratory. This research was led by Dr. George Smoot who consequently won the Nobel Prize for Physics in 2004. He is an author, speaker and blogger with an international following. He was twice listed as a finalist for the Atlanta Power 30 Under 30 Awards. A structural engineer by profession, he holds a professional engineer's license (P.E.) in the State of Georgia and a structural engineer's license (S.E.) in the State of Illinois. He was also awarded the Model Law Structural Engineer Certificate (M.L.S.E.) by the National Council of Examiners for Engineering and Surveying. He is the founder of The Cracked Door Foundation, an organization dedicated to empowering young professionals with biblical principles. He obtained a BS in applied physics from Morehouse College, along with a BS and an MS in civil engineering (structural emphasis) from Georgia Institute of Technology. - www.faithscienceonline.comBecome a supporter of this podcast: https://www.spreaker.com/podcast/the-x-zone-radio-tv-show--1078348/support.Please note that all XZBN radio and/or television shows are Copyright © REL-MAR McConnell Meda Company, Niagara, Ontario, Canada – www.rel-mar.com. For more Episodes of this show and all shows produced, broadcasted and syndicated from REL-MAR McConell Media Company and The 'X' Zone Broadcast Network and the 'X' Zone TV Channell, visit www.xzbn.net. For programming, distribution, and syndication inquiries, email programming@xzbn.net.We are proud to announce the we have launched TWATNews.com, launched in August 2025.TWATNews.com is an independent online news platform dedicated to uncovering the truth about Donald Trump and his ongoing influence in politics, business, and society. Unlike mainstream outlets that often sanitize, soften, or ignore stories that challenge Trump and his allies, TWATNews digs deeper to deliver hard-hitting articles, investigative features, and sharp commentary that mainstream media won't touch.These are stories and articles that you will not read anywhere else.Our mission is simple: to expose corruption, lies, and authoritarian tendencies while giving voice to the perspectives and evidence that are often marginalized or buried by corporate-controlled media

Zuletzt haben wir schwache Bewegungen an den weltweiten Handelsplätzen gesehen. Einige Experten warnen auch immer stärker vor einer KI-Blase und auch Bitcoin und Gold schwächeln. „Es gibt keine Einbahnstraße an den Märkten - nicht nach unten und nicht nach oben. Wir haben eine Angst, dass die Überbewertung der KI-Branche übertrieben ist. Wir haben diese Aussetzung der Zinssenkung wahrscheinlich im Dezember. Wir wissen ja, Zinssenkung ist das Schmiermittel der Aktienmärkte. Der längste US-Shutdown aller Zeiten geht den Menschen auf die Nerve. Das sind so Dinge, wo man denkt, ob man nicht mal Gewinne mitnimmt", so Robert Halver. Der Experte von der Baader Bank über KI-Aktien weiter: „Ich nenne es die rationale Blase. Rational, weil diese Branche Zukunftscharakter hat." Alle Details im Interview von Inside Wirtschaft-Chefredakteur Manuel Koch an der Frankfurter Börse und auf https://inside-wirtschaft.de

The reason for all that Paul has instructed thus far in his letter is found in this section. God's grace and the gospel is the foundation upon which everything else stands. Memorizing these words allows us to keep them as our focus as we study Paul's instructions for this Cretan church and the church today. All teaching, doctrine, and patterns of relating with one another must be built upon the good news of Jesus' redemption.  For this week continue to **work on memorizing Titus 2:13** stacking it onto vs 11-12For the grace of God has appeared that offers salvation to all people. It teaches us to say “No” to ungodliness and worldly passions, and to live self-controlled, upright and godly lives in this present age, while we wait for the blessed hope—the appearing of the glory of our great God and Savior, Jesus Christ, ---Titus 2:11-13

In this episode, host Dr Anna Volkmer is joined by Dr Alys Griffiths, Sophie Jeffery, and Esther Whittlesea Reed to explore a two-year Alzheimer's Society project testing #psychotherapy for people with dementia. Together, they discuss the importance of therapy in #dementia care, the barriers to access, the development of new therapist competencies, and the lived experience of psychotherapy from both clinical and personal perspectives. -- Takeaways

On this week's show we have an essay from one of our listeners on why he wants to stick with his DVR over streaming. We also take a deep dive into Automatic Content Recognition and how to turn it off on your smart TVs. As usual we also read your emails and take a look at the week's news. News: Disney pulls channels from YouTube TV as carriage deal expires DIRECTV now offering the Disney Bundle free to select customers TV Set-Top Box Losing Market Dominance Please support Movember and enter to win great prizes from Bright Side Home Theater Movember Raffle — Bright Side Home Theater Swimming against the Stream - An essay from Jorge Beltran  I know I will sound old and swimming against current, but I would like to go back to my world where we had our cable subscriptions, DVR and Netflix.  Simple, vs having to manage 5-7 subscriptions to watch what we want at a cost we can pay. The proliferation of streaming services is turning out to be a way for content owners to extract more value from customers and significantly increase the amount of work customers have to do to find and track the content we want to watch.  Even sports.  Furthermore, it has backfired to content producers, with less opportunity to monetize content, driving them to look for economies of scale again.  I follow or used to follow La Liga, Premier League Soccer, ski, college football, and formula 1 racing. Back in the day I knew what channel carried all of these sports on my cable line up, would set it to record on my DVR and done.  I could watch it when I wanted and where I wanted since I could access my DVR from anywhere but the plane.  Netflix was just growing and buying "older" content from the major networks and allowed us to binge watch old series we had missed.  Some new exclusive content was coming out and that made paying the 10 - 12 $/mo a good value. Fast forward to today: The best games of Premier League have been taken off the over the air or regular cable channels are now behind a Paramount or someone else's paywall.  Why am I going to pay for access to content that is mostly CBS that I can get over the air?.  Worst of all, you can not skip commercials when you stream this content nowadays.  You can't DVR the content and skip the commercials. I have lost track of who is now airing La Liga, but last time I checked was behind some other streamer.  Fubo has a lot of soccer but is now super expensive too.   Conclusion:  I have stopped following La Liga and Premier League.  My enthusiasm for good Futbol has gone down tremendously.  I turned my eyes to college football and Formula 1.  The worst part is that now I fear the same is going to happen with College Football, moving from free over the air or in basic cable channels to some exclusive need-to-pay streaming service.  You guys praised Formula 1 going to Apple.  I dread it!!! I do not pay for Apple TV(plus or not plus) and I catch Formula 1 over ESPN.   Does it mean I will have to drop ESPN, that gives me other content and add AppleTV?  If I were an NFL fan I would have lost it. Some content is on Amazon, other in the different networks or streamers.  I do not know how much you have to pay to be able to watch the NFL consistently.  Call me old school.  I still have a cable service that gives me the right to HBO, ESPN, Fox, and the likes.  I can watch and record all the related content in Hulu from the major networks. I only keep paying for Netflix that I see as a premium channel (like paying for HBO back in the day).  Rationale - we get a lot of exclusive content there.  I only keep the Disney/Hulu bundle cause it comes free with my wireless bill. And Amazon Prime (now with commercials) free for the shipping.  But I barely watch Primer or Hulu cause I can't stand the commercials! In a world with many streamers, the economies of scale enjoyed by bundling content in cable packages have been lost and thus it costs more per viewer for content owners to create and distribute given the less # of eyeballs.  Yes, it sounds counter intuitive, but that translates into higher bills for consumers, through different bills but when you add it all up, it has to be more expensive, no way around it.  The positive is more content and innovation for sure.  You can definitely find more quality content.  But I foresee more partnerships coming to allow the industry to benefit from economies of scale and be able to distribute the cost of expensive content through more subscribers / viewers.  Or they will have to continue to increase our subscription bills.  I listened to an interview recently with a Hollywood producer detailing how cost efficient they have to be nowadays to be able to turn a profit on content produced given the lower number of ultimate viewers. This is a good thing, do not get me wrong.  But my point is we are coming full circle and a lot of inefficiencies have been introduced in the content value chain and made the experience more time consuming and difficult for viewers in the process.  I think the industry has shot itself on the foot.  Content that used to be free over the air is now behind a paywall and ALSO with commercials.   Apologies from my broken record Long live my DVR! Jorge What is Automatic Content Recognition (ACR)? Automatic Content Recognition (ACR) is built into most smart TVs (Samsung, LG, Vizio, Roku, Fire TV) and silently identifies everything you watch via your smart TV or any attached device via HDMI. It monitors your streaming, cable, and physical media.  It will even identify any ads you watch. It grabs screen samples, sends them online, and feeds data to manufacturers, streamers, and advertisers for recommendations, targeted ads, and ratings.  Usually on by default, it needs the internet to work. Privacy groups like the EFF warn it tracks your habits without clear ongoing notice. How Does ACR Collect Data from Your TV Viewing? ACR operates passively and continuously (or at set intervals) while the TV is on and tuned to a channel or app.  Here's a step-by-step breakdown of the process: Content Sampling: The TV's built-in software periodically "grabs" a short clip or snapshot of the audio, video, or both from what's currently displayed on the screen. This could be every few seconds or minutes, creating a digital "fingerprint" rather than storing full video. For example: Video fingerprinting: Analyzes pixels, colors, or scene changes (similar to how Shazam identifies songs). Audio fingerprinting: Listens for sound patterns in the broadcast. Watermarking: Detects invisible digital markers embedded in content by broadcasters or studios. This sampling works even for non-smart inputs, like cable or gaming consoles, because it captures whatever is output to the screen. Local Processing: The TV processes the sample on-device to generate a compact fingerprint. Raw clips aren't stored long-term on the TV itself—the data is anonymized to protect bandwidth and privacy (though critics argue these can still be re-identified when combined with other data like your location or device ID). Database Matching: The fingerprint is sent to the manufacturer's cloud servers where it's compared against a massive reference database. This database is built by: Monitoring live TV broadcasts in real-time via data centers. Cataloging known content like shows, movies, ads, and even timestamps for commercials. Matches reveal details such as the program title, channel, duration watched, and ad exposures. Data Aggregation and Transmission: Matched data is aggregated with metadata like your TV's IP address, viewing time, and household size. It's then used or shared: Internally for features like "fewer repetitive ads" or recommendations. With third parties like advertisers and Nielsen for ratings and for cross-device targeting which means you'll see the same ad on your phone after TV exposure. The entire process is designed to be invisible and efficient, running without impacting TV performance noticeably. Why Is This Data Collected? Personalization: To suggest shows/movies based on what you've watched. Advertising: Measures ad views for pricing, retargets viewers across devices, and optimizes campaigns. Measurement: Provides device-specific viewership stats, replacing outdated panel-based surveys. TV Manufacturers Using Automatic Content Recognition (ACR) for Data Collection Manufacturer ACR Usage Details How to Disable (General Steps) Samsung Uses built-in ACR on Tizen OS smart TVs to track viewing behavior, including programs, ads, OTT apps, and gaming. Data supports ad retargeting and is used internally for recommendations. Go to Settings > General > System Manager > Samsung Account > Privacy > Viewing Information Services > Toggle off. (10-37 clicks; also opt out via Samsung account online.) LG Integrates ACR on webOS TVs to fingerprint video/audio for viewing history and ad targeting. Captures screenshots every 10 milliseconds in some models. Settings > All Settings > General > System > Additional Settings > Live Plus > Toggle off. (Buried in menus; check privacy controls.) Vizio Owns Inscape, which licenses ACR data from its SmartCast TVs. Historically sold data to third parties; now requires opt-in after 2017 FTC settlement. Settings > Privacy & Security > Smart Home > Viewing Data > Limit Ad Track > Toggle off. (Opt out during setup or later.) Sony Employs ACR on Google TV/Android TV models to collect viewing data for personalization and ads, often via third-party integrations like Samba TV. Settings > Privacy > Automatic Content Recognition > Toggle off. (Varies by model; check Google account privacy if linked.) Roku (powers TVs from TCL, Hisense, Philips, Sharp) "Smart TV Experience" feature uses ACR on Roku OS to track content across linear TV, streaming, and devices. Data shared for ads and measurement. Settings > Privacy > Advertising > Smart TV Experience > Toggle off. (11-24 clicks; not on Roku sticks, only TVs.)  

In this conversation, May Zabaneh breaks down PayPal's move into stablecoins with PYUSD and why it matters for financial inclusion. We explore how PYUSD could lower costs for cross-border payments, deliver faster settlement, and plug directly into PayPal's existing ecosystem. The discussion covers why PayPal built a proprietary stablecoin, early adoption and real-world use cases, and plans for international expansion. We also examine the role merchants play in crypto acceptance, how DeFi and traditional finance are converging, and why interoperability will be essential in the next phase of digital payments.Chapters00:00 PayPal's Vision for Stablecoins02:47 Why PYUSD? Rationale and Goals05:18 Stablecoin Advantages: 24/7, Inclusion, Cross‑Border08:22 Why Proprietary vs Supporting Others11:06 Unlocking B2B and Rebuilding On‑Chain12:20 PYUSD in the PayPal/Venmo Ecosystem14:21 International Expansion and Global Transfers17:02 Merchant Fit: Categories, Costs, Declines19:32 User Segments: Crypto‑Curious to Super Users23:28 Pay with Crypto: Scaling to Larger Merchants29:38 PYUSD in DeFi: Open and Multi‑Chain32:01 Liquidity, Partnerships, and the Three Pillars35:56 Interoperability and Evolving Roles39:11 AI x Payments: Agent‑Driven Commerce40:42 Finding the Flywheel, What's Next

Pakistan's Military Calculus: Jailing Imran Khan to Disintegrate His Party Hussein Khan (Ambassador Husain Haqqani) Ambassador Husain Haqqani explains the Pakistani military's rationale for keeping Imran Khan imprisoned despite his status as a former Prime Minister. Khan faces various lawfare charges brought by the government, but the underlying strategy is political rather than judicial. The military's calculus is that Khan's party lacks alternate leadership or a succession plan, unlike Pakistan's traditional dynastic parties. Since Khan serves as the sole rallying point and the party stands primarily for good governance under his leadership, the military believes that prolonged imprisonment will cause the party to fade or that Khan will become too old to lead effectively when released.

Is meningeal artery embolization the key to ending the cycle of chronic subdural hematomas? In this episode of the Back Table Podcast, Dr. Paul Gullota from Ochsner Health joins host Michael Barraza to share his technical insights on middle meningeal artery embolization, including patient workup, procedure technique, and post-operative care.---SYNPOSISThe episode begins with a discussion on the evolving role of middle meningeal artery embolization in preventing chronic subdural recurrence. The doctors talk through patient selection and procedural planning for middle meningeal artery embolization, emphasizing the importance of assessing collateral pathways and hemorrhage laterality. Dr. Gullota shares his access techniques, microcatheter and embolic options, and the critical role of teamwork with neurosurgery. He also shares his approach to navigating complex vascular anatomy as well as ensuring appropriate patient follow up.---TIMESTAMPS00:00 - Introduction03:12 - Middle Meningeal Artery Embolization: Rationale and Process04:17 - Patient Evaluation and Procedure Steps06:09 - Outpatient Procedures and Billing07:06 - Candidates for Embolization Post-Evacuation07:56 - Unilateral vs. Bilateral Embolization10:34 - Procedure Techniques and Tools19:48 - Post-Procedure Care and Follow-Up21:35 - Final Thoughts and Conclusion

The Supreme Court's decision in Students for Fair Admissions v. Harvard ended decades of race-conscious admissions in higher education. Supporters argue the ruling restores colorblind fairness, while critics warn it risks undoing decades of progress toward equal opportunity. On this week's Stay Tuned with Preet, Yale Law Professor Justin Driver, author of The Fall of Affirmative Action: Race, the Supreme Court, and the Future of Higher Education, joins Preet to trace the history of affirmative action — from Lyndon Johnson's call for “true equality” in 1965 to the Court's recent decision — and to explore what colleges can still do to build diverse classrooms within the confines of the law. Then, Preet answers your questions about the recent court ruling on deploying the National Guard to Portland, Oregon. In the bonus for Insiders, Justin Driver reflects on how his father's sacrifices shaped his understanding of opportunity and education. Join the CAFE Insider community to stay informed without hysteria, fear-mongering, or rage-baiting. Head to cafe.com/insider to sign up. Thank you for supporting our work. Show notes and a transcript of the episode are available on our website.  You can now watch this episode! Head to CAFE's Youtube channel and subscribe. Have a question for Preet? Ask @PreetBharara on BlueSky, or Twitter with the hashtag #AskPreet. Email us at staytuned@cafe.com, or call 833-997-7338 to leave a voicemail. Stay Tuned with Preet is brought to you by CAFE and the Vox Media Podcast Network. Learn more about your ad choices. Visit podcastchoices.com/adchoices

In this episode of Longevity by Design, our host, Dr. Gil Blander, sits down with Dylan Livingston, CEO at the Alliance for Longevity Initiatives, and Dr. Brenda Eap to explore how public policy shapes the future of aging research. Dylan and Brendan share how their team pushes for legislation that supports healthy lifespan extension, aiming to bring longevity science into the center of national health priorities.Dylan and Brendan explain why policy advocacy is crucial for securing funding for research, reducing regulatory hurdles, and establishing a clear path for new therapies. They outline recent successes, including building bipartisan support in Congress and expanding access to experimental treatments in states such as Montana. Throughout their discussion, Dylan shows how effective communication,  using stories and simple analogies, helps move longevity from the lab to lawmakers' agendas.The episode closes with practical advice for listeners. Dylan highlights the power of community, clear communication, and grassroots action as tools that help turn advanced science into real-world health gains.Episode highlights:[00:00:00]: Introduction[00:01:00]: Overview of Longevity Policy and Research Funding[00:02:00]: Backgrounds and Personal Journeys into Longevity Advocacy[00:05:00]: Inspiration and Founding of Longevity Policy Organization[00:07:00]: Scientific Training and Motivation for Policy Work[00:09:00]: Mission and Approach of Longevity Advocacy Organization[00:10:00]: Policy Advocacy's Role in Advancing Longevity Research[00:12:00]: Gaps in Funding and the Importance of Government Engagement[00:13:00]: Experiences with Policy Events and Realizations about Advocacy[00:14:00]: Early Accomplishments and Congressional Engagement[00:15:00]: Building Bipartisan Support and the Longevity Science Caucus[00:16:00]: Legislative Engagement and Policy Paper Development[00:17:00]: State-Level Policy Wins and Expansion of Right to Try Laws[00:19:00]: Rationale and Strategy for State-Level Focus[00:21:00]: Plans for Geographic Expansion of Longevity Policy Initiatives[00:23:00]: Political Climate and Opportunities with the Current Administration[00:25:00]: Shifts in Federal Attitudes Toward Longevity and Healthspan[00:27:00]: Demographics, Policy Momentum, and National Health Priorities[00:29:00]: Prevention Versus Treatment: Shifting Policy Mindsets[00:32:00]: Communicating Policy Opportunities to a Wider Audience[00:34:00]: Ensuring Longevity Policy Remains Bipartisan[00:35:00]: Intersection of Policy, Science, and Public Engagement[00:37:00]: Funding and Regulatory Challenges in Longevity Research[00:39:00]: Barriers in Clinical Trials and Policy Modernization[00:40:00]: Strategies for Communicating Longevity Science to Policymakers[00:44:00]: Framing Longevity for Policy Impact and Public Understanding[00:48:00]: Future Vision and Milestones for Longevity Policy[00:51:00]: How Individuals and Organizations Can Support Longevity Advocacy[00:55:00]: Practical Longevity Advice and Episode ConclusionWe Appreciate You!As a token of our gratitude, we're excited to offer you 15% off your next purchase. Simply click the link below to redeem your discount: https://info.insidetracker.com/podcastFor science-backed ways to live a healthier, longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast

We're discussing 2 controversial topics with Stassi Cramm, President of the Community of Christ. We'll focus on the controversial sale of Kirtland Temple, as well as the schism that followed the 1984 revelation on women's ordination. Which was more controversial? Check out our conversation... https://youtu.be/CIv5kq-x648 1984 Schism & Its Aftermath The 1984 revelation that allowed women to hold the priesthood led to an immediate schism within the church, which was then known as the RLDS Church. President Cramm, who was not present at the 1984 conference, describes the period as rancorous with hard feelings. Following the decision, there were significant conflicts, including debates over property ownership and padlocks being put on church doors as whole congregations pulled away from the main body of the church. The opposition was so strong that a resolution to rescind the 1984 revelation was brought forward at the 1986 conference, though it did not pass. President Cramm contrasts this divisive experience with how the church handled the more recent, and also potentially divisive, issue of same-sex marriage in the early 2010s. Learning from the past, Church leadership approached the topic more slowly, with years of study and conversation. They developed "the principles of faithful disagreement," which allow members to hold differing opinions on church decisions without being judged as unfaithful. While the church still lost members after implementing new policies on same-gender marriage in 2013, the schism was not as severe as in 1984. Today, there are still members who do not believe women should be ordained, and some voiced their opposition to President Cramm's call at the most recent conference, which she notes is acceptable within the church's framework. Sale of Kirtland Temple A significant portion of the conversation addresses the recent sale of Kirtland Temple and other historic sites to The Church of Jesus Christ of Latter-day Saints. This decision was very difficult and emotional, comparable in some ways to the 1984 revelation. Key points regarding the sale: Lack of Conference Vote: The decision for the sale of Kirtland Temple was made by church leadership without a vote or formal input from the World Conference delegates. This was a major point of contention for members who felt the process contradicted the principle of common consent. A resolution was brought to the most recent conference demanding that future property sales receive conference approval, but it was ruled out of order. Rationale for Bypassing Conference: President Cramm explained that the resolution was ruled out of order because it conflicted with the scriptural and bylaw authority granted to the First Presidency and the Presiding Bishopric to act in the church's best overall interest. She also stated that giving 2,800 delegates enough information to make an informed recommendation was not feasible, and that leadership needed to be trusted to do their difficult job. Negotiation Secrecy: The negotiations on sale of Kirtland Temple were conducted under a non-disclosure agreement (NDA), which President Cramm described as a mutual decision to manage how information was released. A public debate or vote would have weakened the church's negotiating position, especially since it was determined that the LDS Church was the only entity capable of providing the necessary funds while ensuring the site's continued maintenance and accessibility. Financial Necessity: The sale was driven by a looming financial shortfall that threatened the church's ability to function globally. Leadership had a legal and moral obligation to keep the church operating and to ensure they could be good stewards of their properties. When it became clear they could no longer afford to properly maintain the temple, selling it was seen as the best option to preserve it. Response to "Revelation" Argument: When asked about the argument that the temple was given by...

Is the economic rationale of soil health always the top priority for farmers? Or, do other soil values rise to the top of farmers' minds, for example, having a healthy habitat for soil fungi? Kasper Krabbe, a doctoral student at Aarhus University in Denmark and a visiting guest scholar at Virginia Tech, returns to talk with Mary, Jeff, and Eric about his research into understanding farmers' intrinsic and extrinsic values in caring for soil. Kasper states that a deeper understanding of farmers' values and motivations is needed because of the degraded condition of agricultural soils globally. For instance, peer pressure to maintain and strive for tidy fields can inhibit experimentation with alternative minimum till systems and diverse cropping mixtures because of neighboring farmers' perceptions of certain aesthetics.    The videos Kasper created of his interviews and interactions with cooperating Danish farmers as part of the Soil Values research initiative can be viewed at https://www.youtube.com/watch?v=oxwHRB9ybRM As always, we encourage you to cooperate with other farmers, graziers, and gardeners for peer-to-peer learning and to follow the four core soil health principles: 1) Keep the soil covered -- Cover crops are our friends and allies;2) Minimize soil disturbance -- Practice no-till or gentle tillage in your field or garden as much as possible;3) Maximize living roots year-round -- to improve biodiversity, soil structure, and life in the soil; and4) Energize with diversity -- through crop rotation, farm enterprises, and/or livestock integration.More details about the Virginia Farm-to-Table Feast and Harvest Celebration scheduled for Saturday, October 25, 2025, from 4:00 to 8:00 p.m. at On Sunny Slope Farm in Rockingham, Virginia, can be found at https://virginiafarmtotable.org/2025vaf2tharvestcelebration/To enjoy recent 4 The Soil blog posts and additional soil health resources, please visit https://www.4thesoil.org/blog and https://www.virginiasoilhealth.org/. For questions about soil and water conservation practices, natural resource concerns, and the financial rationale of soil health, call or visit a USDA Service Center, a Virginia Soil and Water Conservation District office, or your local Virginia Cooperative Extension office.  4 the Soil: A Conversation is made possible with funding support from the National Fish and Wildlife Foundation and The Agua Fund. Other partners include the USDA Natural Resources Conservation Service; Virginia Cooperative Extension; Virginia State University; Virginia Department of Conservation and Recreation; and partners of the Virginia Soil Health Coalition.Disclaimer: Views expressed on this podcast are those of each individual guest.To download a copy of this, or any other show, visit the website 4thesoil.org. Music used during today's program is courtesy of the Flip Charts. All rights reserved. 4 the Soil: A Conversation is produced by On the Farm Radio in collaboration with Virginia Tech. The host and co-hosts are Jeff Ishee, Mary Sketch Bryant, and Eric Bendfeldt.

Misery is manufactured and dark forces continue to profit from it. But our light does not die. Let's root ourselves in truth. It will always outlast the empire of lies. The kingdom of God is not confusion, but clarity. In Syria, a one time terrorist is now a statesman. When governments play with human lives. The Spiral Case. Inuit population control from Denmark in the 90's. Implants for twelve year olds. Zero informed consent. Considered too stupid. Compensation is in process. Implementing the eugenics book. Add an extra zero to the numbers. Trump is pressuring them. Child health care at it's worst. Scary similarities to the Covid policies. It's almost like colonialism. Oh, and we funded Smartmatic in Venezuela. A history of USA overthrow policy. Are there voices bold enough to speak out? A historical Syrian speech at the UN. Operation Cyclone is the precedent. It was dripping everywhere with everything. Israel has other plans. It's not just Gaza. Iran nukes are now in play. The status of our assets is constantly changing. Ireland is in the censorship news. Sometimes in intelligence, the environment is the message. Always take the high level and skeptical view. Those skills will serve us all very well in the future.

Merriam-Webster's Word of the Day for September 18, 2025 is: rationale • rash-uh-NAL • noun Rationale refers to an explanation or reason for something said or done. It is often used with for, behind, or of. // City council members who oppose the zoning change should be ready to explain their rationale for voting against it. // She's explained the rationale behind her early retirement. See the entry > Examples: “There is a rationale for commercializing seagrass production, but ecologically sustainable production needs to be at the heart of that business model, and the numbers for doing that simply don't add up at the moment.” — Richard Lilley, quoted in Smithsonian Magazine, 7 Oct. 2024 Did you know? If someone asserts that the word rationale refers to a ration of ale, they are wrong, but that doesn't mean they don't have an actual rationale (a reason, explanation, or basis) for such a claim. “Rationale looks like the words ration and ale jammed together,” they could offer, and while that is true you'd be justified in responding: “Appearances can be deceiving.” Rationale is a direct borrowing of the Latin word rationale, with which it shares the meaning “an explanation of controlling principles of opinion, belief, practice, or phenomena.” The Latin rationale comes from a form of the adjective rationalis (“rational”), which traces back to the noun ratio, meaning “reason.” While the Latin ratio is also the forebear of the English noun ration, referring to a share of something, rationale has nothing to do with a tankard (or stein, or even a pony) of beer.

In this episode, we give a wrap-up of late-breaking clinical science presented at the ESC Congress 2025 in Madrid. First, David Berg presents the DAPA ACT HF-TIMI 68 trial, reporting on dapagliflozin in patients hospitalized for acute heart failure, along with a meta-analysis of SGLT2 inhibitors in this setting. Next, Javed Butler highlights results of the VICTOR trial, a large phase 3 study of vericiguat in chronic heart failure with reduced ejection fraction. Then, Andre Zimerman discusses the PhysioSync-HF trial, comparing conduction system pacing with biventricular resynchronization therapy in patients with HFrEF. Finally, Kieran Docherty shares insights from a community-based study on the benefits of early initiation of disease-modifying therapy in suspected heart failure.   Additional information: Topic 1: With Gregorio Tersalvi, Mayo Clinic, Rochester, MN - USA, David Berg, Brigham and Women's Hospital, Boston - USA and Novi Yanti Sari, Siloam Hospitals Group, Jakarta - Indonesia Results paper: Dapagliflozin in Patients Hospitalized for Heart Failure: Primary Results of the DAPA ACT HF-TIMI 68 Randomized Clinical Trial and Meta-Analysis of Sodium-Glucose Cotransporter-2 Inhibitors in Patients Hospitalized for Heart Failure Replay ESC Congress Hot Line: https://esc365.escardio.org/presentation/312142 Circulation. 2025 Aug 29. doi: 10.1161/CIRCULATIONAHA.125.076575.    Topic 2: With Javed Butler, Baylor Scott & White Health, Dallas - USA and Henrike Arfsten, Medical University of Vienna, Vienna - Austria Results papers: Vericiguat in patients with chronic heart failure and reduced ejection fraction (VICTOR): a double-blind, placebo-controlled, randomised, phase 3 trial Lancet. 2025 Replay ESC Congress hotline: https://esc365.escardio.org/presentation/312148 doi: 10.1016/S0140-6736(25)01665-4.  Vericiguat for patients with heart failure and reduced ejection fraction across the risk spectrum: an individual participant data analysis of the VICTORIA and VICTOR trials Lancet. 2025 Aug 29:S0140-6736(25)01682-4. doi: 10.1016/S0140-6736(25)01682-4.   Topic 3: With Andre Zimerman, Hospital Moinhos De Vento, Porto Alegre - Brazil and Floran Sahiti, University Hospital of Wurzburg, Wurzburg - Germany Methods paper: Conduction system pacing vs biventricular resynchronization in heart failure with reduced ejection fraction and left bundle branch block: Rationale and design of the PhysioSync-HF Trial Am Heart J. 2025 Dec:290:38-45. Replay ESC Congress: https://esc365.escardio.org/session/50327 doi: 10.1016/j.ahj.2025.06.002.   Topic 3: With Kieran Docherty, University of Glasgow, Glasgow - UK and Jolie Bruno, Inserm UMR-S942, Paris - France Results paper: Benefit of early initiation of disease-modifying therapy in community-based patients with suspected heart failure Eur Heart J. 2025 Aug 29:ehaf675. doi: 10.1093/eurheartj/ehaf675.    This 2025 HFA Cardio Talk podcast series is supported by Bayer AG in the form of an unrestricted financial support. The discussion has not been influenced in any way by its sponsor. 

In this podcast, experts Virginia Kaklamani, MD, DSc, and Tiffany A. Traina, MD, FASCO, discuss the rationale for and data to support combining TROP2-targeting antibody-drug conjugates (ADCs) with immune checkpoint inhibitors (ICIs) to treat triple-negative breast cancer (TNBC).

The Chrisman Commentary Daily Mortgage News Podcast delivers timely insights for mortgage lenders, loan officers, capital markets professionals, and anyone curious about the mortgage and housing industry. Hosted by industry expert Robbie Chrisman, each weekday episode breaks down mortgage rates, lending news, housing market trends, capital markets activity, and regulatory updates with insightful analysis, expert perspectives, and conversations with top professionals from across the mortgage industry. Stay informed, gain actionable insights, and keep up with developments in mortgage banking and housing finance. Learn more at www.chrismancommentary.com.In today's episode, we go through all things Federal Reserve. Plus, Robbie sits down with Potomac Core's Dan Varroney for a discussion on why the Federal Reserve should cut rates 50-basis points this week due to weakening labor markets and recent inflation data. And we close by looking at the overall economic narrative in the wake of recent data points.CreditXpert is the all-new credit optimization platform that helps you close more loans. CreditXpert is committed to making homeownership more accessible andaffordable for ALL.

In this podcast, experts Filipa Lynce, MD, and Rita Nanda, MD, discuss unmet needs in triple-negative breast cancer (TNBC) and the rationale for using TROP2-targeting antibody-drug conjugates (ADCs) in this disease.

Have any questions, insights, or feedback? Send me a text!Length of article: 2 pagesLength of audio: 8 minutes 28 secondsSynopsis: This is the audio version of the 2-page article I wrote and published on rabbischneeweiss.substack.com/ on 9/5/25, titled: Ki Teitzei: Ibn Kaspi's Radical Rationale for Sending Away the Mother Bird. He'd sum up the rationale by saying: "You're nothing but a lowlife ass, a cabbage, and a dumb rock who'd cannibalize his own father. Become a vegetarian!"-----The Torah Content for the month of September is sponsored by Meir Areman in loving memory of his grandmother, Esther Chasha bas Meir Gedalya, who recently passed away on the 25th of Av. Tehei nishmasah tzerurah b'tzror ha'chayim.My Zoom account has been sponsored for the entire year by Isaac and Aviva Lichter, with hakaras ha'tov to Hashem in honor of Navonah's first birthday: “We couldn't have known how much joy and wonder she'd bring into our lives. רבות מחשבות בלב איש, ועצת ה' היא תקום."-----If you've gained from what you've learned here, please consider contributing to my Patreon at www.patreon.com/rabbischneeweiss. Alternatively, if you would like to make a direct contribution to the "Rabbi Schneeweiss Torah Content Fund," my Venmo is @Matt-Schneeweiss, and my Zelle and PayPal are mattschneeweiss at gmail. Even a small contribution goes a long way to covering the costs of my podcasts, and will provide me with the financial freedom to produce even more Torah content for you.If you would like to sponsor a day's or a week's worth of content, or if you are interested in enlisting my services as a teacher or tutor, you can reach me at rabbischneeweiss at gmail. Thank you to my listeners for listening, thank you to my readers for reading, and thank you to my supporters for supporting my efforts to make Torah ideas available and accessible to everyone.-----Substack: rabbischneeweiss.substack.com/YU Torah: yutorah.org/teachers/Rabbi-Matt-SchneeweissPatreon: patreon.com/rabbischneeweissYouTube Channel: youtube.com/rabbischneeweissInstagram: instagram.com/rabbischneeweiss/"The Stoic Jew" Podcast: thestoicjew.buzzsprout.com"Machshavah Lab" Podcast: machshavahlab.buzzsprout.com"The Mishlei Podcast": mishlei.buzzsprout.com"Rambam Bekius" Podcast: rambambekius.buzzsprout.com"The Tefilah Podcast": tefilah.buzzsprout.comOld Blog: kolhaseridim.blogspot.com/WhatsApp Content Hub (where I post all my content and announce my public classes): https://chat.whatsapp.com/GEB1EPIAarsELfHWuI2k0HAmazon Wishlist: amazon.com/hz/wishlist/ls/Y72CSP86S24W?ref_=wl_sharel

Today's host was Michael Wear, Founder, President and CEO of the Center for Christianity and Public Life.  Thanks for listening to The Morning Five! Please subscribe to and rate The Morning Five on your favorite podcast platform. Learn more about the work of the Center for Christianity and Public Life at www.ccpubliclife.org. Scripture: Ecclesiastes 5 Top Headlines: 1) Judge Throws Wrench in Trump Troop Plans 2) Court Seeks to Promote Competition, Declines to Breakup Google 3) Stop Being Weird Today's host was Michael Wear, Founder, President, and CEO of the Center for Christianity and Public Life.  Join the conversation and follow us at: Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@michaelwear⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, @ccpubliclife Twitter: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@MichaelRWear⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, @ccpubliclife and check out ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@tsfnetwork⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Music by: King Sis #politics #faith #prayer #Nadler #2026 #House #Democrats #Xi #Modi #Putin #China #Russia #India #Ukraine #ForeignPolicy #unions #WhiteHouse #executiveorders Learn more about your ad choices. Visit megaphone.fm/adchoices

Today, I'm taking you on a solo exploration into the world of extra virgin olive oil—a topic that's both well-loved in ancestral diets and increasingly backed by cutting-edge science. Inspired by my recent interview with TJ Robinson of the Fresh Pressed Olive Oil Club, I started looking deeper into what makes extra virgin olive oil so powerful for health and longevity. What I found truly surprised me: there's a wealth of research showing just how crucial high-quality olive oil is to the benefits of the Mediterranean lifestyle. Try the Fresh Pressed Olive Oil Club and get a $39 bottle of extremely fresh olive oil for just $1 for shipping. No catch, no subscription required. Go to GetFreshLongevity.com   Resources from the episode: Bioactive Compounds and Quality of Extra Virgin Olive Oil Protective Effects and Benefits of Olive Oil and Its Extracts on Women's Health EVOO's Effects on Incretin Production: Is There a Rationale for a Combination in T2DM Therapy? Xenohormetic and anti-aging activity of secoiridoid polyphenols present in extra virgin olive oil FREE Peptide Book: natniddam.com/free   What we discuss: Mediterranean diet and lifestyle overview ... 00:04:30 What makes olive oil "extra virgin" ... 00:08:15 Key bioactive compounds in olive oil ... 00:12:03 Major health benefits and research highlights ... 00:19:10 GLP-1 activation, gut, and heart health ... 00:20:17 Olive oil's role in women's health and longevity ... 00:21:28 Ways to use extra virgin olive oil ... 00:24:16 Final tips and episode close ... 00:28:39   Our Amazing Sponsors: Berberine Breakthrough by BiOptimizers - Take 15 min. before a meal and your body will push carbs and glucose into your muscles to be used as fuel instead of turning them into fat. Enjoy more stable energy without the post-meal crash. Visit bioptimizers.com/bionat and enter the code BIONAT to get 10% off your order.   More from Nat:  YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

The Soundtrack to your 2025 MLB season is back again as The Brow Flow takes you on a journey through beats and baseball. Lock in on everything you missed this week from MLBbros across the league and the new music that tells their stories. Executive produced by Da Gambler & KRP Productionz. SONG: MLBbro Show (Drill Time) SONG: Diamond Mining Ryan’s Rationale w/Ryan Holt (Best Baseball Bets) Numbers Man w/Sebastian Baugh (Jeremiah Jackson) SONG: CJ Abrams (No.5 Is An Issue) SONG: Jazz Chisholm Anthem FACTZ w/Charlie Dunkin (Yankees Bro Blasts) KRP Drop Going Deep w/OG Mark Gray (Give Jackie Rob His Props) SONG: We Can Play All Day Black Ace Report w/Justin Petrille Top 5 MLBbros Of Week w/Young Critt SONG: Ooh La La Brett’s Reps w/Brett Quintyne (Dusty Baker & Gary “Sarge” Matthews) KRP Drop See omnystudio.com/listener for privacy information.

In this episode of Bitcoin Politics Weekly, host Frank Corva speaks with Rwandan activist Anaïse Kanimba. From her father's kidnapping and imprisonment to her fight for freedom, Anaïse shares how Bitcoin became a lifeline for her family. She explains why Bitcoin matters for refugees, democracy movements, and communities across Africa. They also discuss the founding of the African Bitcoin Institute and its mission. Don't miss this powerful story of resilience, human rights, and financial freedom.

The Chimps have nothing to talk about so, of course, they find something to talk about…

Jeff Bemis runs 1031 Specialists. 1031 Specialists help real estate owners swap one investment property for another to defer taxes and grow rich.Summary of the PodcastIntroduction to 1031 SpecialistsJeff Bemis, co-founder of 1031 Specialists, is introduced. 1031 Specialists helps real estate investors in the United States leverage a tax code section called 1031 to defer capital gains taxes when selling and reinvesting in investment properties.Overview of 1031 ExchangesJeff explains how 1031 exchanges work - if an investor sells an investment property and reinvests the proceeds into a new investment property, they can defer paying capital gains taxes. This provides a unique tax advantage compared to other financial assets like stocks. The 1031 code has existed for over 100 years and is widely used by real estate investors.Benefits and Rationale of 1031 ExchangesThe 1031 code was originally intended to encourage the productive use of farmland by allowing farmers to defer taxes when expanding or relocating. Over time, it has expanded to incentivize real estate investment and development in underserved areas. The deferred taxes must eventually be paid, but the ability to build wealth through tax-deferred reinvestment is a major benefit.Comparison to UK Tax RulesKevin compares the 1031 exchange rules in the US to the capital gains tax rollover relief in the UK, noting that the US has a much higher estate tax exemption limit compared to the UK, making 1031 exchanges even more advantageous for building generational wealth.1031 Specialists' Business Model1031 Specialists' core business is acting as a qualified intermediary to facilitate 1031 exchanges, safeguarding client funds and ensuring transactions comply with IRS rules. They have built a team with deep expertise in real estate and 1031 exchanges to provide efficient service to clients.Competitive Landscape and Growth OpportunitiesJeff notes that while there is competition, 1031 Specialists has become one of the larger players in their niche. They see significant white space in the market, as many individual real estate investors are unaware of or underutilize 1031 exchanges. Educating this market is a key focus for their growth.Leveraging Technology and AI1031 Specialists has built their own AI tool to provide automated answers to common 1031 exchange questions, recognizing that while AI can be helpful, the real estate industry tends to be a late adopter of new technologies. They are focused on using technology to improve internal efficiency and client experience.The Next 100 Days Podcast Co-HostsGraham ArrowsmithGraham founded Finely Fettled ten years ago to help business owners and marketers market to affluent and high-net-worth customers. He's the founder of MicroYES, a Partner for MeclabsAI, where he introduces AI Agents that you can talk to, that increase engagement, dwell time, leads and conversions. Now, Graham is offering a Generative Engine Optimisation Website Auditor that gets you ready to be found by LLM search.Kevin ApplebyKevin specialises in finance transformation and implementing business change. He's the COO of GrowCFO, which provides both community and CPD-accredited training designed to grow the next generation of finance leaders. You can find...

Twitter Space 15 July 2025In this episode, I explore the foundations of ethics and morality in the context of atheism, questioning the source of truthfulness without God. I challenge atheists to articulate their own rationale for morality, critiquing common justifications that often lack depth. Through personal anecdotes and listener engagement, I examine the implications of self-interest in ethical reasoning and stress the importance of accountability. This dialogue promotes a re-evaluation of moral principles, aiming to establish a coherent ethical framework that guides our interactions in a secular world.FOLLOW ME ON X! https://x.com/StefanMolyneuxGET MY NEW BOOK 'PEACEFUL PARENTING', THE INTERACTIVE PEACEFUL PARENTING AI, AND THE FULL AUDIOBOOK!https://peacefulparenting.com/Join the PREMIUM philosophy community on the web for free!Subscribers get 12 HOURS on the "Truth About the French Revolution," multiple interactive multi-lingual philosophy AIs trained on thousands of hours of my material - as well as AIs for Real-Time Relationships, Bitcoin, Peaceful Parenting, and Call-In Shows!You also receive private livestreams, HUNDREDS of exclusive premium shows, early release podcasts, the 22 Part History of Philosophers series and much more!See you soon!https://freedomain.locals.com/support/promo/UPB2025

Scott Wu is the co-founder and CEO of Cognition, the company behind Devin, the world's first AI software engineer. On Friday last week they pulled off the acquisition of the year, acquiring Windsurf, following their licensing agreement with Google. Previously a world-class competitive programmer, he was a gold medalist at the International Olympiad in Informatics and a member of the U.S. Math and Physics Olympiad teams. Before Cognition, he was a founding engineer at Scale AI, helping shape the early AI infrastructure stack. AGENDA: 00:00 – Why are founders walking away instead of going down with the ship? 01:05 – How did Cognition pull off the $220M Windsurf deal in just 72 hours? 04:45 – What really happened behind closed doors the weekend Windsurf was acquired? 07:15 – Did Google overlook a goldmine in the Windsurf team and IP? 09:00 – Who are the 100 people that secretly shape the future of AI? 12:30 – Can application startups ever gain leverage over foundation model giants like Anthropic? 14:15 – Is coding about to be replaced by simply describing what you want? 17:30 – 50% of new code is AI-written. Where does that go next? 20:45 – “We've gone from 0 to $80M ARR in 6 months. Quietly.” 25:00 – Are IDEs and agents just the training wheels for the real future of software engineering? 28:20 – If you could only back one—OpenAI or Anthropic—who's the better bet? 30:00 – Why has Cognition kept its insane growth a secret… until now?