Podcasts about Rationale

Scott Wu is the co-founder and CEO of Cognition, the company behind Devin, the world's first AI software engineer. On Friday last week they pulled off the acquisition of the year, acquiring Windsurf, following their licensing agreement with Google. Previously a world-class competitive programmer, he was a gold medalist at the International Olympiad in Informatics and a member of the U.S. Math and Physics Olympiad teams. Before Cognition, he was a founding engineer at Scale AI, helping shape the early AI infrastructure stack. AGENDA: 00:00 – Why are founders walking away instead of going down with the ship? 01:05 – How did Cognition pull off the $220M Windsurf deal in just 72 hours? 04:45 – What really happened behind closed doors the weekend Windsurf was acquired? 07:15 – Did Google overlook a goldmine in the Windsurf team and IP? 09:00 – Who are the 100 people that secretly shape the future of AI? 12:30 – Can application startups ever gain leverage over foundation model giants like Anthropic? 14:15 – Is coding about to be replaced by simply describing what you want? 17:30 – 50% of new code is AI-written. Where does that go next? 20:45 – “We've gone from 0 to $80M ARR in 6 months. Quietly.” 25:00 – Are IDEs and agents just the training wheels for the real future of software engineering? 28:20 – If you could only back one—OpenAI or Anthropic—who's the better bet? 30:00 – Why has Cognition kept its insane growth a secret… until now?    

There is no doubt that the tariff back and forth is causing challenges for agriculture and the overall U.S. economy. Ted McKinney, CEO of the National Association of State Departments of Agriculture, says that imbalance has to be rectified.

Another wild weekly ride of beats and baseball with the MLBbro All-Stars. As we approach the All-Star break in Atlanta, we have several MLBbros to enjoy during the Midsummer's Classic. Notably, Aaron Judge (Yankees), Jazz Chisholm Jr. (Yankees), James Wood (Nats), Byron Buxton (Twins). Check out three of these Bros in the Home Run Derby. Intro: It's All-Star Week With MLBbro (Da Gambler) Brett’s Reps w/Brett Quintyne: Minnesota Twins Soul Patrol -- Shannon Stewart, Torii Hunter, Jaque Jones Ryan’s Rationale w/Ryan Holt: Pick Your Weekend MLB Winners Goign Deep w/OG Mark Gray: Spoken Word All-Star Edition (MLB All-Star Game) Black Ace Report w/Justin Petrille: Still No Hunter Greene Numbers Man w/Sebastian Baugh: The Metrics Say Jazz Chisholm Is Elite SONG: Chitty Bang Bang (Bro Gang/Da Gambler/KRP SONG: Get After It (Da Gambler/KRP) SONG: Jazz Chisholm Came to The Yankees (Da Gambler/KRP) Chritt's Countdown: Top Bro Plays Of The Week SONG: Ooh La La (Da Gambler, KRP) www.mlbbro.com See omnystudio.com/listener for privacy information.

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From July 1st onwards, Delhi started enforcing a fuel ban on End-of-Life Vehicles or ELVs. In Delhi, this means diesel vehicles older than 10 years and petrol vehicles older than 15 years. This enforcement drive followed an order from the Commission for Air Quality Management (CAQM) stipulating no fuel for ELVs from July 1. But now, following a public outcry, the Delhi government has written to CAQM asking for this fuel ban to be put on hold “with immediate effect”. The reasons it has cited include “critical operational and infrastructural challenges” and ‘public discontent and outcry”. While the enforcement drive raising a public outcry is understandable, it cannot be denied that Delhi's air quality has become a year-round emergency which needs counter-measures. How was this decision to ban 10-year-old diesel cars and 15-year-old petrol cars arrived at? Is this a practical policy in a poor country like India where for many, their vehicle is linked to their livelihood? Are there better ways to weed out polluting vehicles? What about retro-fitting older vehicles to make them less polluting? Guest: Anumita Roychowdhury, Executive Director, Research and Advocacy, Centre for Science and Environment, Delhi. Host: G Sampath, Social Affairs Editor, The Hindu Produced and Edited by Jude Francis Weston Learn more about your ad choices. Visit megaphone.fm/adchoices

Ashkan Shoamanesh, MD, FRCPC - Can We Find a New Way Forward in Secondary Stroke Prevention? Exploring the Rationale and Potential Roles for Factor XIa Inhibition

Ashkan Shoamanesh, MD, FRCPC - Can We Find a New Way Forward in Secondary Stroke Prevention? Exploring the Rationale and Potential Roles for Factor XIa Inhibition

Ashkan Shoamanesh, MD, FRCPC - Can We Find a New Way Forward in Secondary Stroke Prevention? Exploring the Rationale and Potential Roles for Factor XIa Inhibition

Ashkan Shoamanesh, MD, FRCPC - Can We Find a New Way Forward in Secondary Stroke Prevention? Exploring the Rationale and Potential Roles for Factor XIa Inhibition

In this episode, we hear a strong statement defending a person, as depicted in Sangam Literary work, Aganaanooru 22, penned by Veri Paadiya Kaamakanniyaar. Set amidst the cascades and slopes of the 'Kurinji' or 'Mountain landscape', the verse paints a portrait of the beliefs and rituals of those times.

In this episode I talk through my r17 nrl fantasy trades and strategy update + the private group team situation!Join the new Facebook group which is replacing the discord group herehttps://www.facebook.com/share/g/1AQavXJogu/?mibextid=K35XfPCome and join a big group of people that love talking NRL Fantasy. Receive advice from myself and other superstar players including Riley 5th, Bevan 8th, Hayden 9th and Mitch 21st (2024). Be in the running for big prizes as seen last year with 2 x $1000 winners.What is included in this year private group is below:- Massive Top 10 Written Analysis (20th, 50,100,500,1000,2000 included for comparison)- Massive Top 10 Video Analysis (20th, 50,100,500,1000,2000 include for comparison)- The 3 Best Season Long Trading Strategies after analysing the top 10- The 4 Different ways the top 10 made the top 10 (Each strategy works)- My Trading Checklist- My clear team structure plans (how many guns, cows etc)Private Group During Season Posting Schedule (Written)Sunday- Results Thread - Result & Rank + 1 thing you did right and wrong - help everyone learn on the run (8pm)Monday- Early Trade Thoughts Thread - Who are you wanting to rage trade, who do you want? (9am)Tuesday- My top 3 teams to target rankings Thread - You can provide your thoughts in comments (12pm)- Questions for Jamie Thread (5-6pm) (Written answer then release video to Private Group Wed (5:30pm). Public release Thursday (5:30pm)Wednesday- Trades Discussion Thread - I start with my thoughts then add yours in comments (9am)- My Buy/Hold/Sell Rankings with risk % Thread (3-5pm)Thursday- My Captaincy Rankings Thread (12pm Gameday)Friday- Weekend Thread (Looping, late changes, my changes, do I take this score or not?)Full Season Pricing & What You Get (4 Tiers)JBFA Private = $25 AUD- Access to the exclusive private Facebook Group & Group Chat with likeminded people which includes:My weekly best buys, teams to target, captaincy rankings, trades discussion, late mail, my late changes & nrl physio insider news.- Post your questions in the weekly thread answered by me in the thread or on the channel & podcast (Q&A video = private members questions only. Received 12-24hrs before public)- Contribute to the private group consensus team- Finals fantasy accessPayment DetailsAustralian Bank AccountJamie BrownBSB: 062692AN: 41028639Wise.com. (good overseas option)Or PayPalJamie@wattlecomms.com.auDM me or email me at jamie@wattlecomms.com.au when you have paid.#nrl #nrlfantasy #nrlfantasy2025 Hosted on Acast. See acast.com/privacy for more information.

In this episode, Dr. Scott Sigman sits down with Dr. Timothy Codd, a shoulder and elbow specialist out of Baltimore, Maryland, and Dr. Christopher Baker, who specializes in sports medicine and shoulder reconstruction in Tampa, Florida. Here, they discuss their philosophies on rotator cuff reconstruction and repair. This episode is brought to you by Anika.

The truth is out there Hosted on Acast. See acast.com/privacy for more information.

St. Joseph Foundation president and canon lawyer Philip Gray on the Buffalo Catholic the Diocese's rationale on which parishes should pay how much toward the clergy abuse settlement full 565 Wed, 18 Jun 2025 08:30:00 +0000 xPAvc0wKtOu6bRJVCVz2Ozjlvdi5HNOf buffalo,news,wben,buffalo catholic diocese,st. joseph foundation,canon law,philip gray WBEN Extras buffalo,news,wben,buffalo catholic diocese,st. joseph foundation,canon law,philip gray St. Joseph Foundation president and canon lawyer Philip Gray on the Buffalo Catholic the Diocese's rationale on which parishes should pay how much toward the clergy abuse settlement Archive of various reports and news events 2024 © 2021 Audacy, Inc.

Men and Women at Church(1 Timothy 2:8-15)For the bulletin in PDF form, click here. Message SlidesLiberty or Limits for Women - SwindollMen and Their Prayers - SwindollThe Modesty Conversation We Need to Have - Meagan HillWomen and Their Adornment - Stott1 Timothy 2:8-15: Explanation of the Text - Bill MounceImportant Context: “Great is Artemis of the Ephesians” (Acts 19:23-41)• God is God - not Artemis - prominent central goddess of Ephesus• God is Savior - not Artemis - functioned as goddess of midwifery• God's Worshipers are Modest - not Artemis worshipers - extravagant dressDignified Men and PrayerMen Leading Prayer with Intensity and Integrity (2:8) • Positively (2:8a) - approaching God with a holy life• Negatively (2:8b) - avoid hot-tempered controversies Worshipful Women and BeautyWomen Engaged in Worship with Modesty and Witness (2:9-10) • Positively (2:9a) - dress appropriately for church - not seductive• Negatively (2:9b) - don't draw attention to yourself - not affluent• Positively (2:10) - keep the focus on worshipping God - not yourselfVirtuous Women and TeachingWomen Attentively Learning with Trust and Love (2:11-15) • Opportunity (2:11) - Learning with respect• Regulation (2:12) - Not in the authoritative teaching role • Rationale (2:13-15) - Creation Truth in a Cultural Setting[Correcting the Issues of Artemis Priority?]- Creation Order Established: Adam was created first, then Eve.- Creation Order Violated: Adam was not deceived; Eve was fully deceived.- Creation Order Redeemed: Godly women will be saved by God.God has designed the church to be a place of worship where men and women serve appropriately so that nothing distracts people from a focus on God.Mission Prayer Focus: Chris and Vira Loux in UkrainePray for Chris, Vira, and Maggie Loux as they serve at Hosanna Church's family camp in Ukraine, June 22–July 11. The camp will offer rest and renewal for families impacted by war. Pray for lives to be transformed, for God's presence to be felt, and for the Loux family to serve with joy. Ask God for safety, health, and lasting peace in Ukraine.FinancesWeekly Budget 35,297Giving For 06/01 28,376Giving For 06/08 41,383YTD Budget 1,729,561Giving 1,685,161 OVER/(UNDER) (44,400) Men's Ministry Smoke Off | June 21Think you've got what it takes to be PITMASTER? Or maybe it's just about the BBQ and time with the guys. Either way, you're invited. Join us SATURDAY, JUNE 21, from 5–8pm at The Venue for a feast and games. Want in on the Smoke-Off? Sign up to compete when you register. MEN. FOOD. FIRE. What's not to like? Spots are limited—RSVP today. Bring a friend while you're at it. Save your spot at fellowshipconway.org/register.New to Fellowship?We are so glad that you chose to worship with our Fellowship Family this morning. If you are joining us for the first time or have been checking us out for a few weeks, we are excited you are here and would love to meet you. Please fill out the “Connect Card” and bring it to the Connection Center in the Atrium, we would love to say “hi” and give you a gift. Automate the ImportantWe understand that the summer months can be a whirlwind of new schedules and travel. To ensure the continuous growth of Fellowship's ministry, we encourage you to simplify your giving process by automating it. It's a straightforward and hassle-free process. Just visit fellowshipconway.org/give, click “Ready to Give?” then “Recurring,” and fill out the necessary information. If you need any assistance, please feel free to reach out to Emily in our office at 501-327-3444 between 8:30 a.m. and 4:30 p.m., Monday through Thursday. Men's Fellowship BreakfastMen, join us for a great breakfast and fellowship on Wednesday, July 9, at 6:00 a.m. here in the Fellowship atrium. No sign-up is needed. Come with your Bible ready to eat, fellowship with other men, and start your day off right through prayer and Biblical insight. Questions? Contact Michael at mharrison@fellowshipconway.org.​Prayer During ServiceWe love to pray for one another. Our prayer team will have people at the front of the Auditorium under the signs Hope and Love to pray for you after the message. Please feel free to walk up to them for prayer or encouragement during the first worship song after the message. Downline - 9 Months that will change your lifeApply now for next year's Downline class that starts on August 26th. The program equips individuals to know God's Word and make disciples where God has strategically placed you around the city. Space and time are limited, so visit DownlineConway.com for more information and to submit your application.Atrium Remodel Exciting changes are happening to the Atrium over the next month as we continue inviting people into God's story, equipping and releasing them to become reproducing disciples of Jesus Christ. The remodel includes adding a bathroom stall in both the men's and women's restrooms. The Atrium will be under construction, but usable on Sundays, except the restrooms, which will be closed until mid-July. Please use the bathrooms that are located in the first kids hallway (elevator and stairway area).

Your daily dose of beats and baseball is here! We cover the Black and brown players across MLB and their feats and accomplishments for the week. From High-flying wall climber Denzel Clarke to the Slugger extraordinaire Aaron Judge. It’s all in the music !! Your soundtrack to the season brought to you by the MLBbro flow. Executive Produced by Da Gambler and KRP. SONG: Sunshine and Roses w/Da Gambler & KRP Going Deep W/OG Mark Gray: Denzel Clarke Web Gems Brett's Reps W/Brett Quintyne: George Charles Scott "The Boomer" & Dennis "Oil Can" Boyd SONG: Oh Yeah W/Da Gambler & KRP MLBbro Stars Of The Week: Young Chritt Let's Cook W/Devon Cook: Division Battles Heating Up SONG: Pro Bros Black Ace Report W/Justin Petrille: Oh No Hunter Greene!? SONG: Jazz Chisholm Arrives Ryan's Rationale w/Ryan Holt: Weekend MLB Picks For Expert Gamblers Numbers Man W/Sebastian Baugh: Denzel Clarke is Blowing Up Outro See omnystudio.com/listener for privacy information.

The Trump administration's proposed rule effectively frees power plants from climate regulation of any kind and will almost certainly invite legal challenges. POLITICO's Alex Guillén breaks down how EPA is justifying this rule, the pushback from critics, and how an eventual legal fight could help determine whether the federal government can regulate climate pollution from any sector. Plus, President Donald Trump on Thursday moved to eliminate California's nation-leading vehicle emissions standards. Alex Guillén is an energy reporter for POLITICO. Nirmal Mulaikal is the co-host and producer of POLITICO Energy.  Alex Keeney is a senior audio producer at POLITICO.  Gloria Gonzalez is the deputy energy editor for POLITICO.  Matt Daily is the energy editor for POLITICO. For more news on energy and the environment, subscribe to Power Switch, our free evening newsletter: https://www.politico.com/power-switch And for even deeper coverage and analysis, read our Morning Energy newsletter by subscribing to POLITICO Pro: https://subscriber.politicopro.com/newsletter-archive/morning-energy Learn more about your ad choices. Visit megaphone.fm/adchoices

A Rationale for Sexual Purity, with Pete Chiofalo by Keller, Texas

‘It took the US as a nation 220 years to build up its first $1 trillion of debt, and it's now adding $1 trillion of debt every six months' – Hywel George, Old Mutual Investments.

Diana N. Ionescu, MD - Standardizing pCR Assessment in Early-Stage Breast Cancer: Evaluating Rationale, Methods, and Common Pitfalls

In Episode 17 of BITE BIG, we go behind the scenes of one of Australia's most successful luxury skincare brands, Rationale, with its trailblazing CEO, Shamini Rajarethnam. From navigating global expansion and regional relocation, to staying ruthlessly focused in a fragmented market, Shamini shares the story of building an enduring brand without compromising on values.With a mantra passed down from her father, "Nobody cares how much you know until they know how much you care", Shamini's leadership style is deeply human, deeply strategic, and unapologetically clear on what matters most: purpose, people, and integrity.

The Trump administration has pursued a high tariff policy, reversing the movement to lower trade barriers around the world. The justification for this policy is the presence of trade deficits with other nations. However, what if US trade deficits don't matter?Original article: https://mises.org/mises-wire/what-rationale-behind-current-us-tariff-policy

The Trump administration has pursued a high tariff policy, reversing the movement to lower trade barriers around the world. The justification for this policy is the presence of trade deficits with other nations. However, what if US trade deficits don't matter?Original article: https://mises.org/mises-wire/what-rationale-behind-current-us-tariff-policy

Revisionist history isn't denial—it's the pursuit of truth. Tom DiLorenzo exposes the dangerous "Treasury of Virtue" that justifies endless wars and imperialism.Recorded at the Mises Institute in Auburn, Alabama, on May 16, 2025.

Get ready for another action-packed week of MLBbro beats and baseball as only we can deliver it. 1.Song: Hit The Ball/Da Gambler & KRP & Cameron Jade 2.Gambler’s Voice: What’s Wrong With Jazz Chisholm Jr.’s Bat? 3.Numbers Man w/Sebastian Baugh: Stats Say Aaron Judge Greatest Hitter Ever 4.Black Ace Report w/Justin Petrille: Return of Joe Ross 5.Brett’s Reps w/Brett Quintyne: Eddie Murray & Derek Lee, Gold Glove 1B Bros 6.Top 5 MLBbros Of Week w/ Young Chritt: Money Mike Harris Is Rolling 7.SONG: Don’t Take It Away (Baseball)/Da Gambler, KRP, Cameron Jade 8.Ryan’s Rationale w/Ryan Holt: Pick Your Weekend MLB Winners 9. OutroSee omnystudio.com/listener for privacy information.

My guest today for the second time is Mark Dow. Mark is one of my favourite thinkers on Macro, and his experience at the IMF, the US Treasury, and Wall Street gives him a truly unique perspective for the current moment. As we went through one of the biggest market and policy upheavals of my career, I reached out to Mark to help us make sense of this situation. We recorded this episode on Thursday, the 10th of April, and talked about the general principle behind tariffs, the global trading system, the goals of President Trump, and the market reaction. Please enjoy this conversation with Mark Dow. For the full show notes, transcript, and links to the best content to learn more, check out the episode page HERE. ----- Making Markets is a property of Colossus, LLC. For more episodes of Making Markets, visit joincolossus.com/episodes. Stay up to date on all our podcasts by signing up to Colossus Weekly, our quick dive every Sunday highlighting the top business and investing concepts from our podcasts and the best of what we read that week. Sign up here. Follow us on Twitter: @makingmkts | @ericgoldenx Editing and post-production work for this episode was provided by The Podcast Consultant (https://thepodcastconsultant.com). Show Notes (00:00:00) Welcome to Invest Like the Best (00:00:07) Understanding Tariffs: Historical Context and Rationale (00:01:05) China's Role in Global Trade (00:01:54) Impact of Automation on Jobs (00:03:07) Trump's Trade Policies and Their Implications (00:04:20) Challenges with Current Tariff Approaches (00:05:37) Global Trade Imbalances and Misconceptions (00:06:07) Market Reactions and Economic Consequences (00:21:35) Political Shifts and Economic Policies (00:25:56) Trump's Economic Policies and Wage Stagnation (00:26:42) Tariffs and Their Impact on Small Businesses (00:27:20) Market Reactions and Economic Surprises (00:28:41) Equity and Credit Market Dynamics (00:30:59) China's Strategic Moves and Market Implications (00:33:49) The Fed's Role in Economic Stability (00:39:00) Global Trade Relations and Soft Power (00:49:08) Negotiating with Trump: Strategies and Challenges Learn more about your ad choices. Visit megaphone.fm/adchoices

Tom Does Disney: We check back in with Tom Does Disney for the fallout of his arrest and court. Also ripping some Pokemon packs!? Jamison Newlander: Friend of the show and other half of the Frog Brothers, Jamison Newlander congratulates Jim and Them on getting their Youtube channel back. Terrence Howard: Terrence Howard rants about not giving your man card up for Hollywood and throws the challenge out to all of his haters. THE BEAR!, FUCK YOU, WATCH THIS!, COSMO!, HE'S CHINESE!, BOOGIE NIGHTS!, RICK SPRINGFIELD!, JESSIE'S GIRL!, IMMORTALS!, IT'S REAL!, SHOTGUN VAPE!, MAGIC OF A THEME PARK!, TOM DOES DISNEY!, ARREST!, FALLOUT!, FOLLOW UP!, ARGUMENTS!, LIVE!, TOXIC!, COURT!, LOCKED OUT!, EPCOT!, HANGING!, LONELY!, TRASH CAN!, PONTIFICATING!, BLAME EVERYONE ELSE!, NO RESPONSIBILITY!, EXPLANATION!, THEME PARK MUSIC!, COMPLAINING!, DEPRESSING!, SELF REFLECTION!, GROWTH!, HELL OR HIGH WATER!, CAMEO!, ERIK!, LOST BOYS!, FROG BROTHERS!, JAMISON NEWLANDER!, WINDY PARK!, HOUSE!, HERO!, FAN!, CONGRATULATIONS!, DOES HE KNOW!?, JIM AND THEM!, POP CULTURE!, 2020-EPIC!, ERIK!, TIMELINE!, OBAMNA!, HAIRSPRAY!, NIKKI BLONSKY!, TOILET!, GROSS!, TERRENCE HOWARD!, RAMBLINGS!, BEING A MAN!, SCIENCE!, MAN CARD!, GETTING FUCKED!, HOLLYWOOD!, PERVERTS!, JUSTIN BIEBER!, P DIDDY!, ILLUMINATI!, INSIDE LOOK!, RATIONALE!, HUSTLE AND FLOW!, NOMINATED!, FUTURE PERVERT!, HIDING BEHIND A KEYBOARD!, ACTOR PENIS!  You can find the videos from this episode at our Discord RIGHT HERE!

This week on The Genetics Podcast, Patrick is joined by Kent Rogers, Chief Executive Officer at EveryONE Medicines. They discuss Kent's journey across every side of the desk in the drug discovery space, EveryONE Medicines' efforts to develop antisense oligonucleotides for ultra-rare diseases, and the need to adapt regulatory models for n-of-1 therapies.Show Notes: 00:00 Intro to The Genetics Podcast00:59 Welcome to Kent and his experiences across every side of the pharma ‘desk'06:00 Challenges of commercialization for ultra-rare disease therapies and the advantage of antisense oligonucleotides (ASOs) 10:28 EveryONE Medicines' approach to regulatory bodies12:30 Regulatory feedback and expectations from EveryONE Medicines' platform-based approach to n-of-1 therapies15:47 Differences in regulatory requirements for rare disease across countries 19:53 Insights from being on different sides of the drug development industry22:40 Differences in healthcare systems across countries that can facilitate or impede drug development26:57 Rationale behind focusing on ASOs for treating rare diseases 28:03 Building EveryONE Medicines and Kent's approach to leadership33:20 Lessons from Kent's career37:17 Closing remarks Find out moreEveryONE Medicines (https://www.eomeds.com/)Please consider rating and reviewing us on your chosen podcast listening platform! https://drive.google.com/file/d/1Bp2_wVNSzntTs_zuoizU8bX1dvao4jfj/view?usp=share_link

Drs. Pier Giorgio Cojutti and Navaneeth Narayanan join Dr. Megan Klatt to break down what you need to know about amoxicillin/clavulanate dosing. Tune in to learn more about the PK/PD of amoxicillin and clavulanic acid, how we landed on certain ratios for the treatment of common infections, strategies to optimize dosing for serious infections, and more! References: Oral amoxicillin and amoxicillin-clavulanic acid: properties, indications and usage. Clin Microbiol Infect. 2020 Jul;26(7):871-879. doi: 10.1016/j.cmi.2019.11.028. Epub 2019 Dec 4. PMID: 31811919. New formulations of amoxicillin/clavulanic acid: a pharmacokinetic and pharmacodynamic review. Clin Pharmacokinet. 2005;44(11):1097-115. doi: 10.2165/00003088-200544110-00001. PMID: 16231964. Non-linear absorption pharmacokinetics of amoxicillin: consequences for dosing regimens and clinical breakpoints. J Antimicrob Chemother. 2016 Oct;71(10):2909-17. doi: 10.1093/jac/dkw226. Epub 2016 Jun 20. PMID: 27330071. Augmentin (amoxicillin/clavulanate) in the treatment of community-acquired respiratory tract infection: a review of the continuing development of an innovative antimicrobial agent. J Antimicrob Chemother. 2004 Jan:53 Suppl 1:i3-20. doi: 10.1093/jac/dkh050. PMID: 14726431. Is the standard dose of amoxicillin-clavulanic acid sufficient? BMC Pharmacol Toxicol. 2014 Jul 21:15:38. doi: 10.1186/2050-6511-15-38. PMID: 25047044. MIC of amoxicillin/clavulanate according to CLSI and EUCAST: discrepancies and clinical impact in patients with bloodstream infections due to Enterobacteriaceae. J Antimicrob Chemother. 2017 May 1;72(5):1478-1487. doi: 10.1093/jac/dkw562. PMID: 28093484. Amoxicillin-Clavulanate Breakpoints Against Enterobacterales: Rationale for Revision by the Clinical and Laboratory Standards Institute. Clin Infect Dis. 2024 Aug 16;79(2):516-523. doi: 10.1093/cid/ciae201. PMID: 38626241. Amoxicillin-Clavulanate Breakpoints Against Haemophilus influenzae: Rationale for Revision by the Clinical and Laboratory Standards Institute. Clin Infect Dis. 2025 Feb 24;80(2):481-482. doi: 10.1093/cid/ciae246. PMID: 38709848. No evidence of difference in mortality with amoxicillin versus co-amoxiclav for hospital treatment of community-acquired pneumonia. J Infect. 2024 Jun;88(6):106161. doi: 10.1016/j.jinf.2024.106161. Epub 2024 Apr 23. PMID: 38663754. Population pharmacokinetics and dosing simulations of amoxicillin in obese adults receiving co-amoxiclav. J Antimicrob Chemother. 2020 Dec 1;75(12):3611-3618. doi: 10.1093/jac/dkaa368. PMID: 32888018. Comprehensive guidance for antibiotic dosing in obese adults: 2022 update. Pharmacotherapy. 2023 Mar;43(3):226-246. doi: 10.1002/phar.2769. Epub 2023 Feb 18. PMID: 36703246.

In our second hour, Rich chats with Richmond Mayor, Dr. Danny Avula, about the Diamond District's groundbreaking -- and his first budget for the city.

It ain't just wine country anymore!!  Some of the best craft-brewed beers in the world are right here in the North Bay.  And Danny Wright wants to taste them ALL on Beer Thirty!  With help from the guys at the Sports Meats Beer podcast, catch new episodes on-air every Friday at 8:30am on 97.7 The River : RationAle - Non Alcoholic Hazy IPA!

Send us a textDmitry Silversteyn offers his take on Administration's actions to increase domestic minerals production in the effort to decouple from China-dominated supply chain, its impact on mining and processing companies' prospects, and how investors can take advantage of the potential rebalancing of the critical minerals supply chain.

Nuclear weapons have changed the nature of modern warfare and exerted a profound impact on international politics. The Cold War logic of nuclear deterrence maintains that nuclear-armed states will not attack one another because of fear of massive retaliation, or mutually assured destruction. By this logic, nuclear weapons promote stability and can prevent war.At the same time, however, nuclear weapons created a new dilemma. That is: “How can a state achieve its political objectives through military force without triggering a catastrophic nuclear exchange?”This is a dilemma faced by all countries, especially nuclear powers. States have responded differently to this dilemma. What is China's answer to this strategic dilemma? What has Beijing been doing to gain strategic leverage? How should we evaluate the success of China's approach so far?These issues are the subject of a new book titled Under the Nuclear Shadow: China's Information Age Weapons in International Security. The author, Fiona Cunningham, joins host Bonnie Glaser for this episode. Fiona is an Assistant Professor of Political Science at the University of Pennsylvania. She is also a Faculty Fellow at Perry World House and affiliated with the Center for the Study of Contemporary China and the Christopher H. Browne Center for International Politics at the University of Pennsylvania. Timestamps[00:00] Start[01:59] How do countries cope with the limited war dilemma?[04:00] China's Approach of Strategic Substitution[07:24] Adoption of this Third Approach[11:23] Utilizing Information-Age Weapons[15:49] From Brinksmanship to Calibrated Escalation[21:21] Understanding China's No First Use Posture[26:27] Following China's Model [30:42] An American Response

Physicians play a critical role in philanthropy, particularly in health care, as trusted referral agents for grateful patient giving. This episode explores why physician engagement is essential and how their involvement leads to significantly larger gifts. While doctors shouldn't be asking for donations directly, they can recognize moments of gratitude, engage meaningfully, and transition relationships to development teams. The broader nonprofit sector can apply this approach by leveraging board members, executives, or faculty as trusted connectors. In a shifting philanthropic landscape, where fewer donors are giving but at higher amounts, mastering these relationships is vital for long-term fundraising success.

In our exclusive interview, Dr Uboha discussed the significance of this approval, key efficacy and safety data from the pivotal phase 3 RATIONALE-306 trial (NCT03783442), and considerations for integrating this agent into the ESCC treatment paradigm. 

Dr. Sue Yom, Editor in Chief, co-hosts with Dr. Lachlan McDowell, Consultant Radiation Oncologist at the Princess Alexandra Hospital in Queensland, Australia and our journal's Head and Neck Cancer Section Editor. Guests are Dr. Sean McBride, Radiation Oncologist at Memorial Sloan Kettering Cancer Center and Chief of External Beam Radiotherapy at the Manhattan site, who authored an editorial, Oligometastatic HNSCC: Is SABR the Solution?, and Dr. Juliette Thariat, Professor in Radiation Oncology at Cancer Center Baclesse in Normandy, France, Secrétaire Nationale at the GORTEC, and first author of our featured article, Survival Without Quality of Life Deterioration in the GORTEC 2014-04 "OMET" Randomized Phase 2 Trial in Patients with Head and Neck Cancer with Oligometastases using Stereotactic Ablative Radiation Therapy (SABR) alone or Chemotherapy and SABR.

Welcome to the Oncology Brothers podcast! In this episode, Drs. Rahul and Rohit Gosain are joined by Dr. Anwaar Saeed, Chief of GI Medical Oncology at UPMC, to discuss the recent approval of Tislelizumab, a new checkpoint inhibitor for upper GI malignancies, including esophageal squamous cell cancer, GE junction, and gastric cancer. We dive deep into the studies that led to Tislelizumab's approval, including the Rationale 302, 305, and 306 trials. Dr. Saeed explains the unique mechanism of action of Tislelizumab, its higher binding affinity to PD-1, and how it compares to other PD-1 inhibitors like nivolumab and pembrolizumab. Key topics covered in this episode: •⁠  ⁠Overview of Tislelizumab and its mechanism of action •⁠  ⁠Insights from the Rationale 306 trial and its implications for frontline treatment •⁠  ⁠Discussion on the Rationale 305 trial focusing on adenocarcinoma •⁠  ⁠The importance of PD-L1 testing and biomarker-driven treatment decisions •⁠  ⁠Side effect profiles of Tislelizumab compared to other immunotherapies •⁠  ⁠Future directions in the use of immunotherapy for upper GI malignancies Join us for this informative discussion that highlights the evolving landscape of cancer treatment and the importance of precision oncology. If you find this episode helpful, please share it with your colleagues and leave us a review! YouTube: https://youtu.be/hQeLdpSzGCk Follow us on social media: •⁠  ⁠X/Twitter: https://twitter.com/oncbrothers •⁠  ⁠Instagram: https://www.instagram.com/oncbrothers •⁠  Website: https://oncbrothers.com/ Don't forget to subscribe for more practice-changing discussions in the world of oncology. We are the Oncology Brothers!  

Fury CEO Tim Clark and QPM CEO Normand Champigny, along with Fury SVP Exploration Bryan Atkinson, explain why Fury acquiring QPM makes sense for the shareholders of both companies. Bill Powers conducted the interview at PDAC 2025. Tim Clark, CEO of Fury, commented: “This Transaction is an exciting opportunity given it doubles Fury's land package in the Eeyou Istchee territory in the James Bay Region of Quebec and unites complementary assets, teams, and investor bases which should ultimately increase shareholder value at both companies. Combining QPM's gold and critical minerals portfolio of exploration projects with Fury's projects and strong balance sheet will not only help improve cost efficiency but also add to the potential for new discoveries.” Normand Champigny, CEO and Director of QPM, commented: “We are very pleased to be entering this combination with Fury. By combining with Fury, QPM's shareholders will benefit from the synergies and cost savings of leveraging the combined company's excellent management team for funding and obtaining required permits to continue drilling at Sakami. We believe that the Transaction with Fury offers for QPM shareholders a high potential for share price appreciation in the current gold market environment. The Transaction demonstrates the progress made with our exploration work to date. Fury has the ability to rapidly advance our assets to identify a large gold mineral resource.” Sponsor: https://furygoldmines.com/ Ticker: FURY Quebec Precious Metals: https://www.qpmcorp.ca/en/ Press Releases discussed: https://furygoldmines.com/fury-gold-mines-limited-to-acquire-quebec-precious-metals-corporation/ 0:00 Intro 0:51 Rationale for Fury's acquisition of QPM 2:53 QPM's Sakami gold project 3:47 QPM's Kipawa REE project 5:17 Fury to “focus on gold in James Bay” 6:31 Normand Champigny will be Fury advisor 7:19 Eleonore South drilling ongoing 7:43 Major interest in Committee Bay project 8:18 BMO & PDAC: “a lot of excitement” Sign up for our free newsletter and receive interview transcripts, stock profiles and investment ideas: http://eepurl.com/cHxJ39 Sponsor Fury Gold Mines pays MSE a United States dollar seven thousand per month coverage fee. The forward-looking statement found in Fury Gold's most-recent presentation found at www.FuryGoldMines.com applies to everything discussed in this interview. Mining Stock Education (MSE) offers informational content based on available data but it does not constitute investment, tax, or legal advice. It may not be appropriate for all situations or objectives. Readers and listeners should seek professional advice, make independent investigations and assessments before investing. MSE does not guarantee the accuracy or completeness of its content and should not be solely relied upon for investment decisions. MSE and its owner may hold financial interests in the companies discussed and can trade such securities without notice. MSE is biased towards its advertising sponsors which make this platform possible. MSE is not liable for representations, warranties, or omissions in its content. By accessing MSE content, users agree that MSE and its affiliates bear no liability related to the information provided or the investment decisions you make. Full disclaimer: https://www.miningstockeducation.com/disclaimer/

5 Jahre BETREUTES FÜHLEN. Kinder, wie die Zeit vergeht! Grund zum Anstoßen mit NINA CHUBA. Bäääm! Ja, wir sind bisschen spät - 2019 ging's los mit dem Podcast. Wir feiern nach. Nina ist Betreutes Fühlen Fan (wirklich!) und erzählt uns, wie der Podcast ihr in einer schweren Krise geholfen hat. Zusammen mit ihr klären wir, wie man Krisen durchsteht. Klingt erstmal düster, ist aber eine Folge voller Freude und Hoffnung. Auf die nächsten 5 Jahre mit euch und DANKE, dass ihr jede Woche mit dabei seid. Wir senden Herzen in eure Hirne Fühlt euch gut betreut Leon & Atze VVK Münster 2025: https://betreutes-fuehlen.ticket.io/ Instagram: https://www.instagram.com/leonwindscheid/ https://www.instagram.com/atzeschroeder_offiziell/ Der Instagram Account für Betreutes Fühlen: https://www.instagram.com/betreutesfuehlen/ Mehr zu unseren Werbepartnern findet ihr hier: https://linktr.ee/betreutesfuehlen Tickets: Atze: https://www.atzeschroeder.de/#termine Leon: https://leonwindscheid.de/tour/ Bewerbung bei MTS: info@mts-gmbh.com Quellen: Alles zu Professor Bonanno findet ihr in Leons Buch „Besser Fühlen“ im Kapitel zu Trauer. Im Detail auf Englisch aber auch hier: Bonanno, G. A. (2004). Loss, trauma, and human resilience: Have we underestimated the human capacity to thrive after extremely aversive events?. American psychologist, 59(1), 20. Bonanno, G. A. (2019). The other side of sadness: What the new science of bereavement tells us about life after loss. Mehr zu posttraumatischen Wachstum: Tedeschi, R. G., & Calhoun, L. G. (2004). Posttraumatic growth: conceptual foundations and empirical evidence Das Duale Prozess Modell wird auch ausführlich in Leons Buch BESSER FÜHLEN beschrieben. Die Originalstudie: Schut, M. S. H. (1999). The dual process model of coping with bereavement: Rationale and description. Death studies, 23(3), 197-224. Produktion: Murmel Produktions

In this episode, Droste hosts a discussion with Trewkat (Miss Katrina) and Adam Miller (The Thriller) about Black Flag DAO's new membership structure and legal entity formation. The conversation, originally recorded as a Twitter Space on February 18th, covers the transition from BanklessDAO, new membership tiers, staking requirements, and upcoming events. Key topics include the special membership opportunity for former BanklessDAO members (ending March 2nd, 2025), the formation of a Marshall Islands DAO LLC, and an upcoming social gathering with Chippi fam at EthDenver!Important Dates- Deadline for Discounted Staking: March 2nd, 2025- ChippiCon and BlackFlag Social at EthDenver: February 26th, 2025Timestamps[00:00] Show Introduction and Time-Sensitive Updates- March 2, 2025 discounted staking deadline for existing Level 1 BanklessDAO members[02:00] X Space intro banter and historical context with TheThriller (Adam Miller)[06:15] Background on Transition from BanklessDAO with Trewkat (Miss Katrina)[08:30] Staking Discount, Deadline and Rationale for returning members vs new members[11:00] New Member Criteria and Structure Details announced in January- Flag Curious: Entry Level Access (free)- Flag Raiser: 500 USDC Stake + Social Consensus- Flag Bearer: Advanced Membership Requirements + Voting Rights[16:30] Transition mechanism through March 2 for existing L1 members[20:00] Staking Mechanism and Pool Details[22:30] Historical Context and Governance[24:00] Related Community Projects and Updates[27:00] BCard x ChippiCon[28:30] Black Flag Initiative[30:00] Chippi children's book on Amazon, more Chippi talk[34:00] Legal Entity Formation with MiDAO[39:00] Community Impact and Evolution[41:00] Closing chatter[42:00] Note on How to DAO book by Kevin Owocki & Puncar[43:00] Wrap upLinks and Resourceshttps://x.com/BlackFlagDAOhttps://warpcast.com/~/channel/blackflaghttps://blackflagdao.notion.site/https://www.chippicon.com/#https://linktr.ee/chippinfthttps://getbcard.iohttps://app.banklessacademy.com/newsletterhttps://warpcast.com/banklessacademyPresentationhttps://docs.google.com/presentation/d/1-2Dio4GaPW2vF8FNBFHXrS0cdOtmGk0Fy2fbu3GvKO4/edit?usp=sharingAnnouncementshttps://banklessdao.substack.com/p/bfd-bulletin-1https://paragraph.xyz/@bfbulletin/black-flag-bulletin-2Making Bank is produced independently on behalf of BlackFlag DAO

Pores and blackheads—everyone’s got them, but do we really know how to deal with them? Can you actually shrink pores? Are blackhead strips a scam? Dermatologist Dr. Shammi Theesan is here to bust the biggest myths, share what actually works, and spill her own skincare routine for smoother, clearer skin. LINKS TO EVERYTHING MENTIONED: Check out Dr Shammi's previous episode of You Beauty about all things acne here. Minimalist AHA 25% + PHA 5% + BHA 2% Peeling Solution $20 Paula's Choice Skin Perfecting 2% BHA Liquid Exfoliant $49 Avene Cleanance Aha Exfoliating Serum $59 The Ordinary Glycolic Acid 7% Exfoliating Toner $20.50 Rationale #4 The PreCleanse Balm $134 Jojoba Company Australian Jojoba $52 La Roche Posay Mela B3 Serum $80 Rationale #1 The Serum $114 Allies of Skin Copper Tripeptide & Ectoin Advanced Repair Serum $281 The Ordinary Salicylic Acid 2% Solution $10.70 Rationale #5 The Serum $194 IS Clinical Active Serum $157 Cetaphil Gentle Skin Cleanser $15 Rationale #4 The Cleanser $80 Paula's Choice Optimal Results Hydrating Cleanser $38 La Roche-Posay Hyalu B5 Hyaluronic Acid Anti-Ageing Serum $75 Rationale #1 The Serum $114 iS Clinical – Pro-Heal Advance+ $154 Profhilo Haenkenium Antioxidant Cream $120 Rejuran Turnover Cream $32 ANUA Heartleaf 70% Intense Calming Cream $42 SUBSCRIBE: Watch us on Youtube Subscribe to Mamamia Sign up for our free You Beauty weekly newsletter for our product recommendations, exclusive beauty news, reviews, articles, deals and much more! GET IN TOUCH: Got a beauty question you want answered? Email us at youbeauty@mamamia.com.au or send us a voice message, and one of our Podcast Producers will come back to you ASAP. Join our You Beauty Facebook Group here. You Beauty is a podcast by Mamamia. Listen to more Mamamia podcasts here. CREDITS: Hosts: Erin Docherty Guest: Dr Shammi Theesan Producer: Cassie Merritt Audio Producer: Tegan Sadler Mamamia acknowledges the Traditional Owners of the Land we have recorded this podcast on, the Gadigal people of the Eora Nation. We pay our respects to their Elders past and present, and extend that respect to all Aboriginal and Torres Strait Islander cultures.Become a Mamamia subscriber: https://www.mamamia.com.au/subscribeSee omnystudio.com/listener for privacy information.

On this episode we sample and fight over Weller 12 year while talking about jumping on board the same train of thought, a mail call from RationAle, our 4th Weller, dark chocolate and college library, earrings on a dog, the Yacht Rock of bourbon, Nick's read a couple of books, a novel that's challenging comfort food, getting some things off of your chest, The Muppets Christmas Carol, Born in the USA, Nick's Gatsby tattoo, Can't get Peter Parker out of my head, So We Read On, wanting some version of home, spoiling a 100 year old book, tomorrow will be better, you can't repeat the past, committing a felony, and why you should stay away from public property.  Support Us On Patreon: https://www.patreon.com/DrepandStone We'd love to hear from you! https://linktr.ee/DrepandStone Don't forget to subscribe! Music by @joakimkarudmusic Episode #281

This is the last time I hope to talk about this for a while. 

Ryan Wilson completed a long and challenging career in the Australian Army spanning 18 years, primarily in the Special Air Service Regiment, where he gained extensive experience leading teams in highly complex and uncertain environments on multiple combat tours.   During his time in the special forces, Ryan experienced many life-changing and challenging situations that sparked his interest in resilience, high performance, and operational management.  Following his military career, Ryan commenced his journey into the whiskey industry, starting in 2020 as Business Development Manager for Whipper Snapper Distillery, and is now the General Manager overseeing the entire operation.      Ryan is active in the veteran support space. He is on the Board of Directors for the Veteran employment non-profit Working Spirit and is the WA manager for the veteran charity Wandering Warriors.  He has recently founded a new charity called Working Paws Australia, which aims to raise money and provide financial assistance for medical bills and other areas associated with retired military and police working dogs.  He holds a BA in Politics and International Studies from Murdoch University and a Master's in Business Administration (MBA) from the University of Western Australia.  He is also a graduate of the Australian Institute of Company Directors (AICD) Course.  Ryan spent much of his career living and working throughout Southeast Asia, particularly Indonesia, and is fluent in Bahasa Indonesian.   More about Ryan:You can learn more about Ryan and the charities he's involved with at his Instagram: https://www.instagram.com/ryanwilson_1984/Timestamps:00:00:22 Introduction to Ryan Wilson00:01:55 Career Overview00:04:16 SAS Selection: What makes people quit?00:07:32 Mental Preparation: How to Keep Going and Stay Out of Your Head00:10:40 Keeping An Internal Compass 00:13:40 Segmenting: A Thousand Manageable Steps, One At A Time00:15:56 Stories of Selection & Low Points00:19:13 What Are My Odds of Making It00:22:20 End of Selection: Three Sentences and You're On Your Way Home00:24:08 The Sword in the Stone Mentality00:27:21 Selection Starts When the Stress Sets In00:28:46 Sponsor Note: Mindfulness in Training App00:31:32 Rationale for Snapping & Trainability 00:36:04 The Ability to Deal With Failure & Setbacks00:39:30 How Powerful Nutrition Is & Can Be00:43:23 Foundation for Metabolic Flexibility00:45:32 Team Dynamics in Selection: Knowing When to Follow & When to Lead00:47:21 Building Trust and Rapport With a New Group00:50:32 Career Progression After Selection00:54:06 Work/Life Balance Compared to the Army00:58:23 Best and Worst Advice Ever Received01:01:39 Outro

Verno and Jacoby both woke up to the absolute bombshell of a trade that now has Luka Doncic with the Lakers and Anthony Davis with the Mavericks and decided to fire up the mics. The guys try to piece together how exactly the biggest trade in NBA history came together and offer their own theories of why the powers that be in Dallas and Los Angeles decided to go through with the deal at this point of the season. They close the show talking through the Luka-LeBron pairing and how the two of them and JJ Redick will make it all work. Hosts: Chris Vernon and David Jacoby Producer: Ben Cruz Social: Keith Fujimoto Learn more about your ad choices. Visit podcastchoices.com/adchoices

Today my guest is Anton Howes head of innovation research at The Entrepreneurs Network, and the historian-in-residence at the Royal Society for the Encouragement of Arts, Manufactures, and Commerce. He is the author of Arts and Minds: How the Royal Society of Arts Changed a Nation and the excellent Substack Age of Invention.  We talked about salt trade in India, the Dutch culture of innovation, the Royal Society of Arts, endogenous versus O-ring theories of growth, why the Industrial Revolution took place in Britain, and much more.  Recorded November 11th, 2024. Read a full transcript enhanced with helpful links. Connect with Ideas of India Follow us on X Follow Shruti on X Follow Anton on X Click here for the latest Ideas of India episodes sent straight to your inbox. Timestamps (00:00:00) - Intro (00:01:29) - History of the Salt Trade and Salt Tax in India (00:11:12) - Harvesting Salt in Bengal (00:17:140 - The Great Hedge of India (00:23:58) - The Rationale for Taxing Salt (00:25:49) - The Western European Salt Trade and Land Control  (00:34:22) - The Dutch Golden Age (00:39:44) - Baltic Salt and New Forms of Sleeching (00:45:51) - Maritime Trade (00:48:24) - Why Did the Industrial Revolution Take Place in Britain and Not Elsewhere? (01:03:14) - Solving the Problem of Debasement in Britain (01:08:33) - The Path to the Royal Society of Arts (01:16:39) - A Culture of Tinkerers and Improvers  (01:20:49) - The Society of Arts' Aims and Legacy (01:31:15) - Theories of Progress (01:40:20) - The Society of Arts and the Tool of Status (01:47:43) - Outro

Got acne scars? You’re not alone. Dr. Shammi Theeson, a top Aussie dermatologist joins us today to reveal the secrets to fading stubborn scars. From the best treatments and affordable skincare routines to busting common myths, Dr. Shammi is here to help you transform your skin without breaking the bank. LINKS TO EVERYTHING MENTIONED: Cetaphil Gentle Skin Cleanser $14.99 Bioderma Sensibio H2O Soothing Micellar Water Cleanser $32.99 RATIONALE 4 THE CLEANSER $120 Avene Cleanance Aha Exfoliating Serum $59.99 iS Clinical Retinol + Emulsion 0.3 $187 Skin-Renewing Daily Micro-Dose Retinol Serum $115 Rational #6 The Night Crème $230 La Roche-Posay Retinol B3 Anti-Ageing Serum $75 The Ordinary Multi-Peptide + HA Serum $29.90 Paula's Choice Pro-Collagen Multi-Peptide Booster $89 Multi Peptides & Gf Advanced Lifting Serum $333 SUBSCRIBE: Watch us on Youtube Subscribe to Mamamia Sign up for our free You Beauty weekly newsletter for our product recommendations, exclusive beauty news, reviews, articles, deals and much more! GET IN TOUCH: Got a beauty question you want answered? Email us at youbeauty@mamamia.com.au or send us a voice message, and one of our Podcast Producers will come back to you ASAP. Join our You Beauty Facebook Group here. You Beauty is a podcast by Mamamia. Listen to more Mamamia podcasts here. CREDITS: Hosts: Erin Docherty Guest: Dr. Shammi Theeson Producer: Cassie Merritt Audio Producer: Leah Porges Mamamia acknowledges the Traditional Owners of the Land we have recorded this podcast on, the Gadigal people of the Eora Nation. We pay our respects to their Elders past and present, and extend that respect to all Aboriginal and Torres Strait Islander cultures.Become a Mamamia subscriber: https://www.mamamia.com.au/subscribeSee omnystudio.com/listener for privacy information.

On their 200th episode of the show(!), Ben and Andrew discuss the Stargate Project and what clarifies about the dynamics between OpenAI and Microsoft. Then: the risks inherent to Stargate investments, the rationale for the corporate structure announced this week, PhD-level agents in 2-3 years, and various lessons from the success of DeepSeek and its latest models.

The EARLY TAVR trial, colchicine after MI, and the TRISCEND II trial of tricuspid valve replacement are the topics John Mandrola, MD, covers in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I. Early TAVR EARLY TAVR https://www.acc.org/latest-in-cardiology/clinical-trials/2024/10/24/14/42/early-tavr Rationale https://doi.org/10.1016/j.ahj.2023.11.019 AVATAR https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.057639 RECOVERY https://www.nejm.org/doi/full/10.1056/NEJMoa1912846 FAME 2 https://www.nejm.org/doi/full/10.1056/NEJMoa1205361 Rajkumar; Faith Healing in Unblinded Trials https://pubmed.ncbi.nlm.nih.gov/29530888/ PARTNER 3 trial https://www.nejm.org/doi/full/10.1056/NEJMoa2307447 EARLY TAVR: A Positive Trial That Fails to Inform Clinical Decisions https://www.medscape.com/viewarticle/early-tavr-positive-trial-fails-inform-clinical-decisions-2024a1000kec II. Colchicine Meta-analysis https://doi.org/10.1016/j.eclinm.2024.102835 Clear-Synergy Rationale https://pubmed.ncbi.nlm.nih.gov/38936755/ COLCOT (post MI) https://www.nejm.org/doi/full/10.1056/NEJMoa1912388 LoDoCo (Chronic CAD) https://www.nejm.org/doi/full/10.1056/NEJMoa2021372   III. TRISCEND II Trial TRISCEND II Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2401918 You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net