National Institute for Health and Care Research

Professor of clinical oncology at the University of Oxford and Clinical Director of the Oxford Institute for Radiation Oncology - Stratified medicine studies: what we have learnt from the set-up and delivery of the adaptive FOCUS 4 trial. Transcript: https://docs.google.com/document/d/1kkNeISk15owBsojhUk68ypHnUueDDcGnD6kv3by_L4w/edit

Dr Emma Gray Assistant Director of Research at the MS Society Development of the multi-arm, multi-stage trial ‘Octopus' for people with progressive MS www.mssociety.org.uk/stop-ms Transcript:https://docs.google.com/document/d/1kaoWeiRiZr7kZczP1omst2FvYWbwVun4VIN2MIzCHfU/edit?pli=1

Dr Hugh Davies chair of the Oxford research ethics committee and was formerly a research ethics advisor to the health research authority. Dr. Davies trained in medicine and was a consultant paediatrician for many years. Transcript: https://docs.google.com/document/d/1JJR0JF_1jPKOoxN45M-xZtD8obbEWd9S3ezHKR5f-K0/edit?usp=sharing

Matt Sydes Professor of Clinical Trials and Methodology at the MRC Clinical Trials Unit at University College London. The importance of communicating trial results to the study participants. Transcript:https://docs.google.com/document/d/1_tCdh1o9gWFsu5yXeTyXf8JDozGWF4qNrVTspeWNoFA/edit?usp=sharing

Professor Sir Munir Pirmohamed - The NHS, the UK's not so secret weapon in delivering Covid-19 research. COVID-19 - the importance of embedding research and the clinical care interface as a whole, working seamlessly together, to improve future outcomes for patients. Transcript:https://docs.google.com/document/d/1tvGNL5rWd7t3NVbtWy1z8HJPzVPfZR9db-NgwmRCXf8/edit?usp=sharing

Professor Thomas Jaki - Professor of Statistics at Lancaster University and Programme Leader at the MRC Biostatistics Unit at the University of Cambridge The AGILE initiative and the advantages and challenges of Platform Trials. Transcript: https://docs.google.com/document/d/1ad6R8yTfRsdna7Wk442ybKHwPB4h5oZF3WzUqqEMubw/edit?usp=sharing

Professor Pam Kearns, Director of the Cancer Research UK Clinical Trials Unit, University of Birmingham The CATALYST trial: Accelerating drug development for COVID-19 Transcript: https://docs.google.com/document/d/1h5c5C15kiTqsPEJPoHXkbcDTD_hbhIBNzSQjQavteLk/edit?usp=sharing

Dr Camille Carroll Associate Professor and Honorary Consultant Neurologist Peninsula Medical School (Faculty of Health). NSL for Neurology NIHR CRN The role of digital technology, such as sensors and wearables, in clinical trials. Transcript https://docs.google.com/document/d/1OwnBt7efXXCn3-DpefjIukDHtrrXYzEg9XmzXfhZQoc/edit?usp=sharing

Dr Kirsty Wydenbach deputy unit manager and senior medical assessor at the clinical trials unit in the MHRA Challenges and advice for complex innovative design trials, and how COVID-19 has impacted on the MHRAs approach. Transcript:https://docs.google.com/document/d/1HS-c3mR-B4m3RCtRpWHb5kIS8Xv90XJ2IIReWOg4fpw/edit?usp=sharing

Yan Yiannakou Clinical Director of the NIHR Patient Recruitment Centre – Newcastle Running a wholly virtual trial during the COVID19 pandemic. Transcript: https://docs.google.com/document/d/1_HkW3ixWip1XtrqUAGeiinQX7J3divCC1tKo_X_HUWg/edit?usp=sharing

Emma Lowe - acting head of research policy for clinical research and growth at the UK department of health and social care (DHSC) - focus on the Innovation in delivery of research studies during the COVID pandemic. Transcript: https://docs.google.com/document/d/13XO3AK7ar2co34e0zT-jPWZ-iI88xavLaqzXo0O09DE/edit?usp=sharing

Following on from our first round of podcasts that evolved from the recommendations in the paper; Effective delivery of Complex Innovative Design (CID) cancer trials- a consensus statement focusing on complex innovative design trials the NIHR CRN coordinating center has again collaborated with the Health Research Authority and in this series, the NIHR Office for Clinical Research Infrastructure. This time, we will be discussing some of the key learning points from the COVID-19 pandemic, such as: - Has the recent success using innovative design and delivery of research studies during the COVID pandemic been part due to the advance of innovation in trials pre-COVID-19? Could Continuous Improvement mean innovation in COVID-19 research inform studies post the pandemic? And how can we evidence this? The general learnings and happenings throughout the COVID-19 pandemic, and we will be building on the further questions around the management and delivery of innovative design trials during the pandemic. From Weds 27th January we will roll out a weekly podcast here aimed at anyone with an interest in designing, delivering or reviewing Innovation in Trail Design and Study Delivery. They are presented by experienced research professionals from across the research environment. The research delivery infrastructure in the UK provided by the NIHR, working closely with the NHS, regulators and stakeholders, continues to deliver unparalleled clinical research activity to address the COVID-19 pandemic. Agility, coordination and innovation are core attributes that are driving this impact made by our clinical research. They are also attributes that will ensure the UK can regrow the comprehensive health and social care research portfolio as soon as the harm of the COVID-19 pandemic upon health and social care is overcome. Drawing upon proven research infrastructure and our culture of continuous improvement from recent experience (such as those shared in this podcast series) provides this platform for future success.

Kelly Fricker is the lead research nurse at The Boathouse Surgery in Pangbourne, Reading. Here she speaks about what her role involves, studies into conditions such as arthritis and chronic obstructive pulmonary disease (COPD) and how her team are able to carry out research in their GP practice with the support of the National Institute for Health Research (NIHR).

Emma Lowe Dept. of Health and Social Care and CID Trials as she discusses the definition of complex innovative trials and on the role of the Dept. of Health and Social Care.

Prof. Julie Lovegrove and Nutritional Research by NIHR

Martin's clinical research interests are in the degenerative dementias, particularly familial disease, and more recently in general cognitive impairment in systemic disease and multimorbidity. He established the Queen Square Dementia Research Centre and has served as the editor of the Journal of Neurology, Neurosurgery and Psychiatry, President of the Association of British Neurologists, Director of the NIHR Clinical Research Network for Dementia and Neurodegenerative diseases (DeNDRoN), and Director of the NIHR Queen Square Dementia Biomedical Research Unit. As part of the activities of DeNDRoN he established Join Dementia Research (JDR), a national system for linking patients and public to research studies. He has served on numerous advisory boards and is currently an associate member of the World Dementia Council, member of the 2020 Dementia Programme Board, and Chairman of the Senate for the German Centre for Neurodegenerative Diseases (DZNE).

Katherine Cowan by NIHR

Prof. Irene Higginson and Palliative Care Research

Peter Bower Multimorbidity by NIHR

Clare Meachin 70 @ 70 by NIHR

Sally Wyke, Interdisciplinary Professor of Health and Wellbeing at the University of Glasgow talks about complex interventions to improve health.

Dr Fiona Thistlethwaite and Advanced Therapies In Clinical Research by NIHR

Dr Matthew Hobbs And The Role Of Single Disease Medical Charities In Research by NIHR

Dr Hugh Davies and Research Ethics Committees

Jennifer Martin (MHRA) And Clive Collett (HRA) And EConsent by NIHR

Primary Care Research With Prof. Philip Evans by NIHR

Joanne Ashcroft and Non-traditional Settings for Clinical Research

Kate Searle talks about how the new Highlight from the NIHR: Management of Labour would have been beneficial reading for her before the birth of her third child.

Prof. Patricia Connolly and Medical Device Research

Medical Devices With Prof. Patricia Connolly by NIHR

Clinical Trials Of Vaccines With Prof. Helen McShane

Dr Mike Clark and Social Care Research by NIHR

Prof. Janet Peacock and Medical Statistics by NIHR

Professor Jeremy Wyatt on why the NIHR is seeking to fund more research into Digital Health and what kind of proposals they would like to see.

Prof. Sandra Eldridge and Pragmatic Clinical Trials by NIHR

Allan and Richard Smith discuss misconduct and fraud in clinical research. by NIHR

Compassion in clinical research with Dr de Zulueta by NIHR

Jonathan Sheffield International Clinical Trials Day by NIHR

Dr Fiona O'Neill and the Development of the Clinical Research Workforce by NIHR

Multi-arm, Multi-stage Clinical Trials with Prof. Allan Hackshaw by NIHR

Dr Jonathan Sheffield Stratified Medicine by NIHR

Shona McDermott Educational Needs of Researchers by NIHR

MHRA GCP Inspections with Jason Wakelin-Smith by NIHR

Research Priority Setting Partnerships with Katherine Cowan

Clinical Research and Brexit with Prof. Emma Cave

Ethical considerations in genetic research with Prof. Nalin Thakker

Systematic Reviews and Meta-analyses with Prof Mike Clarke — Director of the MRC Methodology Hub at the Centre for Public Health in Queen's University Belfast. Virtual Journal Club Link: Investigation of bias in meta-analyses due to selective inclusion of trial effect estimates: empirical study bmjopen.bmj.com/content/6/4/e011863.full

Challenges and Opportunities in Large-scale Trials with Prof David Newby

The Role of the Research Funder with Prof Sir Nilesh Samani by NIHR

Simon Denegri OBE, National Institute for Health Research (NIHR) National Director for Patients, Carers and the Public.

The Nurse's Changing Role in Clinical Research with Dr Susan Hamer — Director of Nursing, Learning and Organisational Development at the National Institute for Health Research Clinical Research Network Coordinating Centre.