Podcasts about tpoab

Welcome back to our weekend Cabral HouseCall shows! This is where we answer our community's wellness, weight loss, and anti-aging questions to help people get back on track! Check out today's questions:    Darren: Good day to you, your family and team Dr Cabral. I listened to Dr Rhonda Patrick saying Bananas, Beets, Swiss chard, collard greens have an enzyme in them called polyphenol oxidase which degrades Polyphenols in blueberries and other high polyphenol containing foods. She says it's best not to add them to smoothies with blueberries etc. Is this accurate or the drawback is not that bad?     Jenn: Hi Dr. Cabral! Ever since I was pregnant with my second baby, I get this metal taste in my mouth. It happened during the first trimester, was happening as much during the 2nd but came back in the 3rd. From what I've researched it based on hormonal changes. But 7 months postpartum I'm still experiencing the metal taste every day - typically at night. I thought this goes away after giving birth. I'm so curious as to why this continues to happen and what I can do about it. Thank you so much!!     Vanessa: I have had recurring yeast infections for a year. I have taken a gut test where I collected stool for three days then did the micribiome labs gut support package for six months and cut out most sugar (only in coffee) and went mostly keto/carnivore. Last antibiotic taken three years ago after a surgery. It went well for about four months. Now it's back in my vagina and I get it on two fingers. I have a lot of stress due to a divorce and job (nurse). Please help with a protocol to rid this yeast once and all from my body. Thank you for your time     Carol: Hi dr. Cabral. I have something called Hoffa's syndrome in my knees. I was wondering if you had a natural approach to this, my insurance will cover steroid shots, but do not want to go that route. Or liposuction. Thanks for any advice. I appreciate all you do.     Teresa: Hi Dr Cabral, can you please talk about hashitoxicosis. I have Hashimotos and my latest thyroid tests showed that my TPOab was really high and my other thyroid levels were hyperactive.      Thank you for tuning into today's Cabral HouseCall and be sure to check back tomorrow where we answer more of our community's questions!    - - - Show Notes and Resources: StephenCabral.com/3207 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

Welcome back to our weekend Cabral HouseCall shows! This is where we answer our community's wellness, weight loss, and anti-aging questions to help people get back on track! Check out today's questions:    Dave: Do you recommend the Harmoni pendant for EMF protection? I have seen other people in the natural health space recommend them and I am wondering your thoughts.     Maurna: I have been on thyroid medication for over 25 years. I am 58 and Currently on NP Thyroid. Can I heal my body to the point I would no longer need it? Or has my body shutdown producing hormones due to the fact I have supplemented for so long. Also I have read you should not take melatonin too long because your body will stop producing it. You offer a melatonin supplement so is that false. Thanks for your time and advice. My fiancé and I met later in life and are focusing on health to live our best lives together. We live in WA and are looking forward to when the big 5 lab tests become available.     Kim: Hi Dr. Cabral, Thank you for your effort in teaching the world about health and how we can take ownership in healthily living. My Question: What do you know about Lifewave X39? My doctor recommended I try it for my health issues. I have worsening arthritis and other autoimmune issues. Thank you for your feedback!     Heather: Hey Doc! Appreciate you taking the time to answer our questions as always! I have two questions: 1 - Can you talk a bit about Diabetes Insipidus? My 5-year-old cousin just got diagnosed with it and the doctors are saying he has to be on medication the rest of his life for it. Do you know what underlying root causes can cause this? 2. When I do a harder workout, my face gets real red except the area above my upper lip which the skin tone stays the same. I usually have a little bit of redness on my face daily but again, the area above my lip doesn't go red. So one, what could be the reason for this & two, is it normal for your face to get super red after a hard workout? Thanks again!!   Maria: Is treating an elevated/out of range TPOab part of the thyroid outside the scope of practice of an IHP?     Thank you for tuning into today's Cabral HouseCall and be sure to check back tomorrow where we answer more of our community's questions!    - - - Show Notes and Resources: StephenCabral.com/3165 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

Welcome back to our weekend Cabral HouseCall shows! This is where we answer our community's wellness, weight loss, and anti-aging questions to help people get back on track! Check out today's questions:    Jennifer: I am wondering what your thoughts are on the SPECT (Brain) Scans that Dr Daniel Amen recommends to clients with brain disorders or concerns, especially if there is a history of head injury?     Lara: Hi Stephen, Hope you can help. When i go to bed at night i am tired and ready to fall asleep, then when i almost fall asleep my legs start to itch very badly. I can go on for hours and it wakes me up everynight, sometimes it goes away for a while but always returnes after a few days or weeks.     Kelsi: hi dr. cabral! i have an ayurvedic-based question. i tend to have a pitta imbalance and recently it's been worse than usual. my body has been hot, especially at night, my tongue has a light yellow coating and i struggled with mild insulin resistance + acne (pcos). i'm currently on the CBO protocol and meditating like my life depends on it to calm the body down. my questions are 1) if i'm already running hot, have i been doing myself a disservice by doing the sauna every single day? and 2) is there anything else you'd recommend right off the bat to rebalance pitta?     Anonymous: Hi Dr. Cabral, I am getting into preserving my own food and have been learning about the process. I got a canning book and it splits jam recipes into those with added pectin and those without it. It says that pectin is a fiber naturally found in fruits and vegetables, and that adding it to jams reduces cooking time and increases its ability to gel. Since it is naturally found in fruit I didn't think it would be bad to add, but after some research I am getting conflicted information. Please share your thoughts, you are a trusted voice in our household! Thank you!     Maria: Is treating an elevated/out of range TPOab part of the thyroid outside the scope of practice of an IHP?     Thank you for tuning into today's Cabral HouseCall and be sure to check back tomorrow where we answer more of our community's questions!      - - - Show Notes and Resources: StephenCabral.com/3151 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

Can high TPO antibodies cause hair loss? Learn why you want to lower thyroid antibodies and practical solutions to improve your TPO numbers naturally. Make sure you listen to the end because I will tell you how to get your hands on my free guide, "5 Ways To Lower Thyroid Antibodies".  References: PMID: 28293260PMID: 33025552 PMID: 28223728Listen to the podcast and then get your FREE guide HERE.Connect with us:Kimberly Vaughn, WTS, ITS, CNC, MBA: www.hpihairpartners.comConsultations with Kimberly: https://hpihairpartners.com/consultation-request/IG: HPIHair https://www.instagram.com/hpihair/Nataliia Sanzo, RD, LDN, CHWC www.allpurposenutrition.com...

Welcome back to our weekend Cabral HouseCall shows! This is where we answer our community's wellness, weight loss, and anti-aging questions to help people get back on track! Check out today's questions:    Anonymous: Hi. Thanks so much for taking our questions on your show. I love hearing other people get their answers and learning while I listen. I heard on a previous show that fine lines or wrinkles around the mouth area is not a result of aging but from other causes. I am only 47 and have recently (within the last two years) noticed a significant increase in vertical lines around both my upper and lower lips. Is this from nutrient deficiencies or something else? I did the big 5 labs, have been working with an Equilife IHP, and have been using your products now for 8 months. I was hoping the increased nutrition plus protocols I've completed (21 day detox, CBO, parasites, heavy metal) would have helped but the lines just keep getting more noticeable. Is there any way to get these to go away or can I only hope to keep them from getting worse? Thank you so much for your help!   Wendy: Hi Dr Stephen, can i ask if EMS training is beneficial for weight loss, especially for people over 45 years old? Doing lots of high intensity activities may not be suitable for people aged 45 and above.   Paloma: Thank you so much and your team for all your hard work every single day! I was wondering whether some PMS symptoms are normal or does it always indicate hormonal imbalances?   Paloma: Me again! I once asked you whether you thought cardio was necessary if I got my 10k steps every day + 4x a week resistance training with bands & free weights and you said it wasn't. I'm a 25 year old Vata so I don't like doing a lot of cardio because I lose muscle very easily. You've been speaking a lot about cardio recently so I'm wondering whether your answer would be different now? I don't have a lot of free time so to implement some jogging or biking would mean taking out 1 or 2 days of resistance training…   Tina: First off thank you and your team for all you do. I am a 53 years old. I did the big 5, the gut and bacteria test, and mold test. I am 12 weeks into my protocol working with an IHP level 2. I have done the 14 day functional detox. I am 8 weeks into the CBO protocol. I just finished the intestinal cleanse. I did a parasite cleanse and liver flush. My morning cortisol is very low and my evening cortisol is very high. Thyroid was a little high. I've been taking supplements to support my hormones and I have been doing the deep sleep protocol because I was experiencing really bad insomnia. I still continue to wake up at least four times a night. I'm very thirsty, I wake up startled, I wake up starving , and of course then I have to go to the bathroom because I have been drinking. I've been doing the deep sleep protocol, I've been wearing blue blockers before bed. I recently bought a lief device because my HRV is very very low. On average my number is 16. I also still have very bad Reynards. My fingertips go numb and purple. I also have this scab in my nose that clears up but then comes back quickly. TPOab is 32. Which is very very low. Any other suggestions on what I could be doing? Is my rain barrel that full? Do I need to keep doing functional detoxes? Could it be lyme? Thank you !!   Ryan: Hey doc Cabral. Wanted to ask a question regarding Graves' disease vs hashimotos. When testing thyroid antibodies, i recently heard Amy myers say TSH receptor antibodies is more telling of graves and the thyroid peroxidase and thyroglobulin markers are more telling for hashi's I wanted your thoughts on this, as I am testing these markers every few months in conjunction with near daily red light therapy exposure to thyroid. I did see a reduction in TPO antibodies from about 158 in November last year to 45 this past February. So it is cool to think that it may be lowered due to that exposure. I am a previous Graves patient. But will be looking to get the TSH receptor antibody test next time. Have you seen red light therapy work for these issues? Have you ever noticed any difference in testing those anti body markers for different patients? If TPO is lowering is that a sign that inflammation as a whole for the thyroid is lowering?   Thank you for tuning into today's Cabral HouseCall and be sure to check back tomorrow where we answer more of our community's questions!    - - - Show Notes and Resources: StephenCabral.com/2353 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!

We have never had any good studies looking at how food allergies, or more specifically food intolerances, affect Hashimoto’s disease. A recent paper, however, did show that people following a gluten-free diet can help heal Hashimoto’s disease.  In this article, Dr. Hedberg answers the question if food intolerances affect Hashimoto's disease? I was excited to find a new paper just published last month that looked specifically at food intolerances and Hashimoto’s disease. The paper was published in the Journal of the American College of Nutrition and it was entitled, “Evaluation of Correlations Between Food-Specific Antibodies and Clinical Aspects of Hashimoto’s Thyroiditis.” Let’s break down the study and see what food intolerances may be connected to Hashimoto’s disease. The authors do point out a previous study that showed TSH levels improved in people with Hashimoto’s disease who were lactose intolerant when they avoided consuming lactose. The aim of this study was to evaluate whether testing IgG antibodies for specific foods show differences in people with Hashimoto’s disease compared to those without Hashimoto’s disease. The authors wanted to find out if there were any specific foods connected to Hashimoto’s disease so that those individuals would know what to avoid to help their condition. How was the study done? 74 patients, 91.9% being female, with Hashimoto’s disease had blood testing done for 125 IgG food antibodies. Some of them were taking thyroid medication and some were not (28.17%). They also performed a thyroid ultrasound and tested them for thyroid-stimulating hormone (TSH), thyroxine (T4), free thyroxine (fT4), triiodothyronine (T3), thyroid peroxidase antibodies (TPOAb), and anti-thyroglobulin antibodies (TgAb). Additional markers included body mass index (BMI), height, weight, blood pressure, and asked them how many symptoms they had. I was pleased to see a control group of 245 subject of which 54.7% were women. The control group was also tested for the same 125 IgG food antigens. To test the food antibodies they used enzyme-linked immunosorbent assay or ELISA which is a very popular technique for testing food intolerances. They broke the food intolerances down into these categories: Milk products Eggs Grains Legumes Nuts Fruits Vegetables Fish Seafood Meat Coffee and Tea They also took into account all the differences of the above blood markers, biomarkers, medication, and symptoms to see if they could find any correlations. They even looked at how frequently the subjects were eating specific food groups. What were the results? They found increased IgG antibody responses in 12 foods that were significant but these were elevated in both groups. Of the 12, only plum was significantly elevated in the Hashimoto’s group with egg white and barley showing borderline significance. Interestingly, almond was actually significantly less reactive in the group with Hashimoto’s disease compared to controls. Looking at the proportion of positive results however, only plum and barley were higher in those with Hashimoto’s disease but no significant difference with egg whites. Anti-gliadin IgG antibodies which are specific for gluten were tested but they did not find any differences between the two groups. The authors did not find any correlation with IgG food antibodies and symptoms of Hashimoto’s disease and hypothyroidism. The magnitude of reactivity from strongest to lowest in both groups was: Milk products and eggs > Grains > Nuts > Legumes > Fruits > Vegetables > Fish > Seafood > Meat > Coffee and Tea. Author Discussion The authors conclude that only plum was significant between the two groups with barley and egg white to a lesser extent. They did however find significant connections with thyroid volume and almond-specific IgG levels as well as for nuts, meat, and fish in those taking thyroid medication.

Thyroid disease is an epidemic and occurs about five times more frequently in women than in men. It is estimated that 20% of women above the age of 60 suffer from an underactive thyroid (hypothyroidism). As a medical intuitive, I have worked with hundreds of women who suffer from thyroid disease and there is a distinctive energetic and emotional pattern that drives this disease. In this episode, I will share with you what the energetics of thyroid disease are and what you can do about them. I will also talk about often overlooked nutritional factors and how to get accurately tested for thyroid disease. Biggest Takeaways: The “typical” thyroid patient is: overly giving, too concerned about others, she doesn't know what she wants and what her needs are, she has a hard time setting appropriate boundaries, she can't express her needs and feels disconnected from life. (Min: 4:04) Underlying negative beliefs of thyroid issues are: “I can't have what I want”, “My needs don't count”, “I'm not important”, "It's not save for me to speak my truth". Work on changing the beliefs by putting your hand on your heart chakra. Rub gently in a clockwise motion while going into the feeling of the new belief "I can have what I want", "It`s safe for me to speak my truth", etc. Do this three times per day for a total of six weeks. (Min: 12:16) Bring energy into your thyroid by doing the throat chakra exercise daily. (Min: 18:45) Vitamins and Minerals that are important for proper thyroid function are: Iodine (don't take Iodine if you have Hashimoto thyroiditis), Selenium, Zinc, Copper, Vitamin E, Vitamin D and Vitamin B12. (Min: 27:24) Avoid Gluten and Dairy  See an integrative MD and ask to be tested for: Thyroid Stimulating Hormone (TSH), Total T4, Total T3, Free T4 (fT4), Free T3 (fT3), Reverse T3 (rT3), Thyroid peroxidase antibody (TPOAb), Thyroglobulin antibody (TgAb)Thyroid antibodies.(Min: 30:06)

Aloe vera is one of the oldest medicinal plants we know of that was used by the ancient Egyptians who called it “the plant of immortality.” And 200 years ago Greek scientists considered Aloe vera a “universal panacea.” Aloe vera is technically named Aloe barbadensis and you most likely have heard of using Aloe topically for burns or internally for soothing an inflamed gut. I’ve used Aloe vera over the years as one of the compounds in a gut-healing supplement I use for leaky gut, inflammatory bowel, SIBO, constipation, and irritable bowel syndrome. It works extremely well at reducing inflammation and repairing inflamed and damaged mucus membranes in the gut and the urinary tract. I have also used it quite successfully with the bladder pain caused by interstitial cystitis. Aloe vera is rich in 200 nutritional substances most notably the following: Minerals: Iron Chromium Zinc Selenium Copper Manganese Magnesium Sodium Potassium Calcium Vitamins: A B1,B2,B3,B5,B6,B12 C E Folic acid Enzymes: Alkaline phosphatase Amylase Bradykinase Carboxypeptidase Catalase Lipase Peroxidase Additional compounds: Choline Anthraquinones Sterols Lignins Saponins Salicylic acid The above compounds explain its anti-oxidant, analgesic, antiseptic, anti-viral, and anti-inflammatory properties. Aloe vera has been scientifically shown to be beneficial for the following: Genital herpes Psoriasis Seborrheic dermatitis Burns Wound healing Mucositis Radiation dermatitis Frostbite Acne Lichen planus Apthous stomatitis Type 2 diabetes HIV Cancer prevention Constipation Ulcerative colitis Pressure ulcers Traditional uses not scientifically supported yet include: Parasites Chronic leg wounds Lupus Arthritis Alopecia Bacterial and fungal skin infections Tic douloureux Promising study results on Aloe vera and Hashimoto's Disease New research indicates that Aloe vera may be extremely beneficial for Hashimoto’s thyroiditis in patients with subclinical hypothyroidism. The study was inspired by an individual with Hashimoto’s thyroiditis who drank 50ml of Aloe Barbadensis Miller juice as a laxative and to soothe her skin. She noticed that after drinking this juice for 3 and 6 months, her TSH, Free T4, Free T3, and thyroid peroxidase antibodies (TPOAb) all improved. Her TSH went from 5.14 to 1.83. Free T4 improved from 8.3 to 11.44. Free T3 went from 5.22 to 4.78 which indicates improved efficiency. And TPOAb decreased from 1,875 to 246. These were quite profound changes with no other interventions and no thyroid medication. Based on these results the authors recruited 30 women aged 20-55 with Hashimoto’s thyroiditis and subclinical hypothyroidism which was defined as having a TSH >4.0 and high TPOAb levels. These women had never been treated with thyroid medication before or taken any supplements for their thyroid issues. All 30 subjects drank 50ml of Aloe Vera Miller Juice (ABMJ) manufactured by ZUCCARI (Trento, Italy) every morning on an empty stomach for 9 months. TSH, Free T4, Free T3, and TPOAb levels were measured at baseline, 3 months, and 9 months. The control group consisted of data on 15 women from a university hospital who had Hashimoto’s thyroiditis and subclinical hypothyroidism. What did the results reveal? The control group did not show any statistically significant changes in any of their thyroid test numbers. At three months the study group showed statistically significant improvements in all four thyroid tests. TSH, Free T4, and TPOAb levels all improved again at the nine month mark. Free T3 levels declined at three months but then did not significantly change from three months to nine months. Here are the basic averages during the study: TSH Baseline: 5.19 TSH 3 Months: 3.12 TSH 9 Months: 2.01 Free T4 Baseline: 9.63 Free T4 3 Months: 10.67

AIR DATE: November 1, 2012 at 7PM ETFEATURED EXPERT: FEATURED TOPIC: “Finding The Diet That's Right For You” If you've been listening to my podcasts or read my blog for any length of time, then you've obviously heard me talk about one of the basic philosophies that I think is an important part of living a healthy lifestyle. Here it is: "Find a diet plan that is right for you, follow that plan exactly as prescribed by the author and then keep doing that plan for the rest of your life making appropriate tweaks along the way to keep it working." But how do you go about figuring out what the "right" diet and lifestyle plan is for you? That's what we'll be exploring further in Episode 33 of "Ask The Low-Carb Experts" with a highly-qualified guest expert named  (listen to my March 2012 interview with Peter in ). TRY THESE DELICIOUS NEW PRE-MADE PALEO MEALSUSE COUPON CODE "LLVLC" FOR 10% OFF YOUR ORDERNOTICE OF DISCLOSURE: TRY THE WORLD'S FINEST CACAO BEAN LOW-CARB CHOCOLATEEnter "LLVLC" at checkout for 15% offNOTICE OF DISCLOSURE:  Here are some of the questions we addressed in this podcast: RENEE ASKS:I have been refining what I think is my perfect diet for about 3 years now. During that time my diet has drastically changed for the better. I eat a very strict Paleo autoimmune diet with no dairy, nuts or nightshades. This has worked very well for me and now I am experimenting with a few little things here and there to tweak my diet that help me go from feeling good to feeling great. I am wondering about the cross-reactivity of coffee with gluten. I have heard that this can be a problem for some people, but I dismissed it because I didn’t want to believe that it can be a problem for me. But now I’m thinking that it IS a problem for me because after quitting coffee I started losing weight with no other changes in my diet. And it's not just calories because I replaced the coffee with a coconut oil cocoa that would have equal calories since I made my coffee into a coconut oil latte anyway. I know that gut issues are the minority of manifestation of gluten intolerance, so this effortless weight loss might be showing some type of healing. I also heard that a study came out early this year confirming that a coffee/gluten cross reactivity is a significant problem. What are your thoughts on this issue? MICHAEL ASKS:I'd like to hear Peter address hypercaloric feeding on a ketogenic diet in combination with weight training. Is it possible for someone who is already basically lean and healthy to overeat and train his way up in size? What is the likely practical limit to size gain and performance in weightlifting with insulin levels being kept very low? MIKE ASKS:I have found success stabilizing my weight on a diet of 20-30g of carbs per day. However, I can't seem to lose those last stubborn pounds. I am a 5'8" male and currently weight 160 pounds with 19% body fat. My goal is to get down to 15% body fat. I started monitoring my ketones and after a month was able to lose another 4 pounds and 1% body fat, but it was very hard for me to maintain the high percentage of fat in my diet required to get my ketones high enough. Recently I started slow lifting and I really like that program. But when I increased my protein to aid muscle development I knocked myself out of ketosis and am right back to the 19% fat, 160-pound mark. I suspect a hormonal problem is contributing to the difficulties in losing but I’ve tested my testosterone twice and both times it’s near the high end of the "normal range." Recently my TSH also tested fine at 1.9, my Free T4 Direct was in the middle of the lab range at 1.32, and my TPOab was also in the middle at 12. My Free T3 was on the low end of the lab range at 2.2 (with the lowest reference range being 2.0). Given all of the above, are there variations I could try in my diet that could get me unstuck and help me reach my goal? MARYANN ASKS:I’m a 76-year old woman with the H63D gene for hemochromatosis and have high ferritin. My latest test was 436 and it goes up and down with an all-time high of 625. My doctors says that a phlebotomy is unnecessary unless it goes over 1000. I also have paroxysmal atrial fibrillation which I understand eating the Paleo way is the best for this. My A fib discussion board members say my ferritin is way too high now. What diet would you say would be the best for me? TINA ASKS:I am 42 years old and have been overweight since having children in my early 20s. I am 5'4" and weigh 199 pounds. My A1c was 5.8 when I check it a few months ago and my doctor advised me that I’m at risk for Type 2 diabetes and that I need to start exercising 30 minutes per day. I have been playing around with low-carb/Paleo and primal diets for the past few months but I can't decide which way to go. I have read tons of information and listen to many health podcasts like the ones from Jimmy Moore, Balanced Bites and Fat Burning Man. Where do I start? I crave sweets at least once a day and that continues to be my biggest downfall. How do I pick the diet that’s right for me? PALEOZETA FROM AUSTRALIA ASKS:I would like Dr. Attia to talk about intermittent fasting and…well, diarrhea. Sorry. About 10 minutes after I eat again following an intermittent fast, which works very well for me in conjunction with my ketogenic diet, I tend to have one or two bouts of diarrhea. I was reading that it could be our body expelling the toxins in it, but I’m not so sure about that. I’ve heard other people who do IF having this same issue. Do you have any insights about this? JAN ASKS:I'm a peri-menopausal woman, and I eat a low-carb, high-fat version of primal. My doctor is pushing statins on me strictly on the basis of my LDL-C which registered in at 142 using the Freidewald Equation. My HDL is 79 and my triglycerides are 71. Because of my insurer and financial situation, getting an NMR Lipoprofile test to measure my LDL-P is out of my reach to better assess my risk factors. I can't even get them to do a C-Reactive Protein test to assess whether there's inflammation. Is there any dietary tweak I can make to bring LDL-C lower without negatively impacting my excellent HDL and triglyceride readings? ERIC ASKS:It seems very timely that Dr. Attia will be on your podcast, Jimmy, as your latest Apo B results showing 238 and an LDL-P score of 3451 would appear to be quite alarming based on his recent “The Straight Dope On Cholesterol” series. Since Dr. Attia is a huge fan of ketogenic diets AND has a lot of knowledge about the importance of lipid markers, I would imagine he would be in a fantastic position to help clarify what is going on here. He seems to believe that the Apo B number is one of the most important markers of cardiovascular health. By the way, what is Dr. Attia’s Apo B number? JACK ASKS:Since cycling is a topic that is rarely addressed in Paleo/low-carb circles, does Peter have any tips for maximizing endurance athletic performance while on a ketogenic diet? Whenever I try to do cycling while in ketosis, I often feel fatigued and lose some of my power. Alternately, if I eat a lot of carbs and sugar-laden cycling food, I get stomachaches and feel bloated and grouchy most of the ride. Peter's blog has been the only thing I've ever seen talking about this topic and I’d appreciate hearing more from him about this. ROGER ASKS:Does a ketogenic diet repair or re-regulate an underactive thyroid? I’ve been on this diet for a year and a half now, but my hypothyroid symptoms still exist although I feel much better. My latest blood tests suggest I have low T3. I’m athletically built, never been overweight and exercise moderately. I’m wondering if Dr. Attia is a proponent of doing any thyroid supplementation in conjunction with a ketogenic diet as a beneficial approach to treating these hypothyroid symptoms? MICHELE ASKS:I heard you mention on your previous podcast with Jimmy that you use vegetables as a vehicle for consuming more fat. How important are vegetables in the diet if you’re eating a high-fat, low-carb diet? I always get confused because you hear how important it is to eat a lot of vegetables but I’m not particularly fond of a lot of them when trying to increase my ketones. TOM ASKS:We often hear the phrase used in the low-carb community that “there’s no dietary requirement for carbohydrate.” I’ve always assumed this comment was directed at the usual suspects like breads, cereals, pastas, legumes, etc. However, I have to ask, are vegetables really necessary to consume? In my case, I’m referring to non-starchy vegetables, such as kale, Brussels sprouts, cauliflower, and so forth. While vegetables contain vitamins, nutrients, fiber, and phytochemicals, I’ve read that cruciferous vegetables are also potentially goitrogenic. Cooking these vegetables for long periods of time supposedly helps to mitigate any deleterious effects, but the suggested cooking time is a minimum of 30 minutes. So what’s the scoop on veggies? DARREN ASKS:Over the past year and a half, I've been following a low-carb diet stopping short of nutritional ketosis. I'd put my daily carbohydrate input close to 100g out of a 2700- calorie diet. It has allowed me to accomplish and exceed the goals that I set out to do: - Lowered my Triglycerides from ~330 to

Background: Three genes have been confirmed as major joint susceptibility genes for endocrine autoimmune disease: human leukocyte antigen class II, cytotoxic T-lymphocyte antigen 4 and protein tyrosine phosphatase non-receptor type 22. Recent studies showed that a genetic variation within the interferon induced helicase domain 1 (IFIH1) locus (rs1990760 polymorphism) is an additional risk factor in type 1 diabetes and Graves' disease (GD). Methods: The aim of the present study was to investigate the role of the rs1990760 polymorphism within the IFIH1 gene in German patients with GD (n = 258), Hashimoto's thyroiditis (HT, n = 106), Addison's disease (AD, n = 195) and healthy controls (HC, n = 227) as well as in 55 GD families (165 individuals, German) and 100 HT families (300 individuals, Italian). Furthermore, the interaction between rs1990760 polymorphism with human leukocyte antigen (HLA) risk haplotype DQ2(DQA*0501-DQB*0201), the risk haplotypes DQ2/DQ8 (DQA*0301-DQB*0302) and the status of thyroglobulin antibody (TgAb), thyroid peroxidase antibody (TPOAb) and TSH receptor antibody (TRAb) in patients and families were analysed. Results: No significant differences were found between the allele and genotype frequencies for rs1990760 IFIH1 polymorphism in patients with GD, HT, AD and HC. Also no differences were observed when stratifying the IFIH1 rs1990760 polymorphism for gender, presence or absence of thyroid antibodies (GD: TRAb and HT:TPOAb/TgAb) and HLA risk haplotypes (DQ2: for GD and HT, DQ2/DQ8: for AD). Furthermore the transmission analysis in GD and HT families revealed no differences in alleles transmission for rs1990760 IFIH1 from parents with or without HLA risk haplotype DQ2 to the affected offspring. In contrast, by dividing the HT parents according to the presence or absence of thyroid Ab titers, mothers and fathers both positive for TPOAb/TgAb overtransmitted the allele A of IFIH1 rs1990760 to their HT affected offspring (61.8% vs 38.2%; p = 0.05; corrected p [pc] = 0.1). However, these associations did not remain statistically significant after correction of the p-values. Conclusion: In conclusion, our data suggest, no contribution from IFIH1 rs1990760 polymorphism to the pathogenesis of either Graves' disease, Hashimoto's thyroiditis or Addison's disease in our study populations. However, in order to exclude a possible influence of the studied polymorphism in specified subgroups within patients with autoimmune thyroid disease, further investigations in larger populations are needed.

Selenium Supplementation in Patients with Autoimmue Thyroiditis Decreases Thyroid Peroxidase Antibodies Concentrations ROLAND GÄRTNER, BARBARA C. H. GASNIER, JOHANNES W. DIETRICH, BJARNE KREBS, AND MATTHIAS W. A. ANGSTWURM Departement of Endocrinology, Medizinische Klinik Innenstadt, University of Munich, D-80336 Munich, Germany In areas with severe selenium deficiency there is a higher incidence of thyroiditis due to a decreased activity of selenium-dependent glutathione peroxidase activity within thyroid cells. Selenium-dependent enzymes also have several modifying effects on the immune system. Therefore, even mild selenium deficiency may contribute to the developpement and maintenance of autoimmune thyroid dideases. We performed a blinded, placebo-controlled, prospective study in female patients (n = 70; mean age, 47.5 + 0.7 yr) with autoimmune thyroiditis and thyroid peroxidase antibodies (TPOAb) and/or Tg antibodies (TgAb) above 350 IU/ml. The primary end point of the study was the change of TPOAb concentrations. Secondary end points were changes in TgAb, TSH, and free thyroid hormone levels as well as ultrasound pattern of the thyroid and quality of life estimation. Patients were randomized into 2 age- and antibody (TPOAb)-matched groups; 36 patients received 200 µg (2.53 µmol) sodium selenite/d, orally, for 3 months, and 34 patients recieved placebo. All patients were substituted with L-T4 to maintain TSH within the normal range. TPOAb, TgAb, TSH, and free thyroid hormones were determined by commercial assays. The echogenicity of the thyroid was monitored with high resolution ultrasound. The mean TPOAb concentration decreased significantly to 63.6% (P = 0.013) in the selenium group vs. 88% (P = 0.95) in the placebo group. A subgroup analysis of those patients with TPOAb greater than 1200 IU/ml revealed a mean 40% reduction in the selenium-treated patients compared to a 10% increase in TPOAb in the placebo group. TgAb concentrations were lower in the placebo group at the beginning af the study and significantly further decreased (P = 0.018), but were unchanged in the selenium group. Nine patients in the selenium-treated group had completely normalized antibody concentrations, in contrast to two patients in the placebo group (by x2 test, P = 0.01). Ultrasound of the thyroid showed normalized echogenicity in these patients. The mean TSH, free T4, and free T3 levels were unchanged in both groups. We conclude that selenium substitution may improve the inflammatory activity in patients with autoimmune thyroiditis, especilally in those with high activity. Whether this effect is specific for autoimmune thyroiditis or may also be effective in other endocrine autoimmune diseases has yet to be investigated. (J Clin Endocrinol Metab 87: 1687-1691, 2002)