Podcasts about c reactive protein

 PRINT THIS AND TAKE IT WITH YOU TO YOUR NEXT ANNUAL PHYSICAL EXAM:  ESSENTIAL BLOOD WORK SCREENING TESTS CHEAT SHEET    February is AMERICAN HEART MONTH, so we're replaying this solo episode where Barbara dives into the essential blood tests and health screenings every midlife woman should ask about during their annual physical. Drawing on expert insights from past episodes, she explains why it's crucial to go beyond routine tests and discusses additional screenings that can help detect potential health risks early. From heart health to bone strength, Barbara encourages listeners to have proactive conversations with their doctors to ensure they're getting the best care as they age.   What You'll Learn in This Episode:    - The importance of the lipid panel for understanding heart health.  - How the Apolipoprotein B (ApoB) test provides a more accurate cardiovascular risk assessment.  - Why high levels of C-reactive Protein (CrP) can indicate dangerous inflammation levels.  - The critical role of Vitamin D for bone and immune health, especially in midlife women.  - How regular blood glucose testing can help catch diabetes early.  - The significance of blood pressure monitoring for heart disease prevention.  - Why women should prioritize bone density tests to prevent osteoporosis.  - The importance of monitoring  waist circumference as an indicator of health risks.  - The need for regular cancer screenings, including Pap smears, mammograms, and colonoscopies, for early detection.    Key Takeaways:    - The lipid panel is foundational to understanding heart health.  - The ApoB test is crucial for assessing cardiovascular risk.  - High levels of C-Reactive Protein indicate chronic inflammation risks.  - Vitamin D is essential for bone and immune health.  - Regular blood glucose tests can catch diabetes early.  - Blood pressure monitoring is vital for heart disease prevention.  - Bone density tests are critical for midlife women.  - Waist circumference is a key indicator of health risks.  - Regular cancer screenings are essential for early detection.    Related Episodes of AGE BETTER:  Learn more about the ApoB and LP(a) tests HERE.   Learn more about inflammation HERE.   Learn more about heart health and atrial fibrillation HERE.  Learn more about blood glucose and insulin resistance HERE.    Connect with Barbara:    Website: BarbaraHannahGrufferman.com    Instagram: @BarbaraHannahGrufferman    X/Twitter: @BGrufferman  Facebook: @BarbaraHannahGruffermanAuthor    Please Rate & Review the Show!    If you enjoyed today's episode, please consider leaving a review or sharing it with someone who would benefit from these essential health tips.  Learn more about your ad choices. Visit megaphone.fm/adchoices

Commentary by Dr. Tzu-Fei Wang.

In this solo episode, Barbara dives into the essential blood tests and health screenings every midlife woman should ask about during their annual physical. Drawing on expert insights from past episodes, she explains why it's crucial to go beyond routine tests and discusses additional screenings that can help detect potential health risks early. From heart health to bone strength, Barbara encourages listeners to have proactive conversations with their doctors to ensure they're getting the best care as they age.    CLICK HERE TO GET THE ‘AGE BETTER CHEAT SHEET ESSENTIAL LIST OF TESTS'   TIP: Take this list with you to your next annual physical exam and discuss with your doctor!    What You'll Learn in This Episode:    - The importance of the lipid panel for understanding heart health.  - How the Apolipoprotein B (ApoB) test provides a more accurate cardiovascular risk assessment.  - Why high levels of C-reactive Protein (CrP) can indicate dangerous inflammation levels.  - The critical role of Vitamin D for bone and immune health, especially in midlife women.  - How regular blood glucose testing can help catch diabetes early.  - The significance of blood pressure monitoring for heart disease prevention.  - Why women should prioritize bone density tests to prevent osteoporosis.  - The importance of monitoring  waist circumference as an indicator of health risks.  - The need for regular cancer screenings, including Pap smears, mammograms, and colonoscopies, for early detection.    Key Takeaways:    - The lipid panel is foundational to understanding heart health.  - The ApoB test is crucial for assessing cardiovascular risk.  - High levels of C-Reactive Protein indicate chronic inflammation risks.  - Vitamin D is essential for bone and immune health.  - Regular blood glucose tests can catch diabetes early.  - Blood pressure monitoring is vital for heart disease prevention.  - Bone density tests are critical for midlife women.  - Waist circumference is a key indicator of health risks.  - Regular cancer screenings are essential for early detection.    Related Episodes of AGE BETTER:  Learn more about the ApoB and LP(a) tests HERE.   Learn more about inflammation HERE.   Learn more about heart health and atrial fibrillation HERE.  Learn more about blood glucose and insulin resistance HERE.    Connect with Barbara:    Website: BarbaraHannahGrufferman.com    Instagram: @BarbaraHannahGrufferman    X/Twitter: @BGrufferman  Facebook: @BarbaraHannahGruffermanAuthor    Please Rate & Review the Show!    If you enjoyed today's episode, please consider leaving a review or sharing it with someone who would benefit from these essential health tips.  Learn more about your ad choices. Visit megaphone.fm/adchoices

En el capítulo de hoy, exploramos los 5 mejores ejercicios para vencer la resistencia a la insulina y mejorar tu salud metabólica. La resistencia a la insulina puede llevar a problemas graves como la diabetes tipo 2, pero afortunadamente, ciertos tipos de ejercicio pueden ayudarte a manejar y revertir esta condición. Si te gusta el contenido y deseas más consejos sobre salud y fitness, asegúrate de darle like, comentar y suscribirte a nuestro canal. ¡Activa la campanita de notificaciones para no perderte nuestros próximos videos! Suscríbete a mi boletín informativo en: www.drmauriciogonzalez.com Sígueme en: YouTube: www.youtube.com/@DoctorMauInforma Instagram: www.instagram.com/dr.mauriciogonzalez/ TikTok: www.tiktok.com/@drmauriciogonzalez Twitter: www.twitter.com/DrMauricioGon CONTACTO ► booking@drmauriciogonzalez.com Fuentes: Jelleyman, C., Jelleyman, C., Yates, T., Yates, T., O'Donovan, G., Gray, L., King, J., Khunti, K., Davies, M., & Davies, M. (2015). The effects of high‐intensity interval training on glucose regulation and insulin resistance: a meta‐analysis. Obesity Reviews, 16. https://doi.org/10.1111/obr.12317. Gallo-Villegas, J., Castro-Valencia, L., Pérez, L., Restrepo, D., Guerrero, O., Cardona, S., Sánchez, Y., Yepes-Calderón, M., Valbuena, L., Peña, M., Milán, A., Trillos-Almanza, M., Granados, S., Aristizábal, J., Estrada-Castrillón, M., Narvaez-Sanchez, R., Osorio, J., Aguirre-Acevedo, D., & Calderón, J. (2021). Efficacy of high-intensity interval- or continuous aerobic-training on insulin resistance and muscle function in adults with metabolic syndrome: a clinical trial. European Journal of Applied Physiology, 122, 331 - 344. https://doi.org/10.1007/s00421-021-04835-w. Dunstan, D., Daly, R., Owen, N., Jolley, D., Courten, M., Shaw, J., & Zimmet, P. (2002). High-intensity resistance training improves glycemic control in older patients with type 2 diabetes.. Diabetes care, 25 10, 1729-36 . https://doi.org/10.2337/DIACARE.25.10.1729. Gordon, B., Benson, A., Bird, S., & Fraser, S. (2009). Resistance training improves metabolic health in type 2 diabetes: a systematic review.. Diabetes research and clinical practice, 83 2, 157-75 . https://doi.org/10.1016/j.diabres.2008.11.024. Castaneda, C., Layne, J., Munoz-Orians, L., Gordon, P., Walsmith, J., Foldvari, M., Roubenoff, R., Tucker, K., & Nelson, M. (2002). A randomized controlled trial of resistance exercise training to improve glycemic control in older adults with type 2 diabetes.. Diabetes care, 25 12, 2335-41 . https://doi.org/10.2337/DIACARE.25.12.2335. Thind, H., Lantini, R., Balletto, B., Donahue, M., Salmoirago‐Blotcher, E., Bock, B., & Scott-Sheldon, L. (2017). The effects of yoga among adults with type 2 diabetes: A systematic review and meta-analysis.. Preventive medicine, 105, 116-126 . https://doi.org/10.1016/j.ypmed.2017.08.017. Atashak, S. (2018). The Effect of Eight Weeks of Pilates Training on C-Reactive Protein, Insulin Resistance, and Body Composition in Middle-Aged Obese Women. Journal of Rafsanjan University of Medical Sciences, 17, 421-434. Learn more about your ad choices. Visit megaphone.fm/adchoices

The Journal of Rheumatology's Editor-in-Chief Earl Silverman discusses this month's selection of articles that are most relevant to the clinical rheumatologist. Sex-Related Differences in Dispensation of Rheumatic Medications in Older Patients With Inflammatory Arthritis: A Population-Based Study - doi.org/10.3899/jrheum.2023-1148 Upadacitinib in Rheumatoid Arthritis and Inadequate Response to Conventional Synthetic Disease-Modifying Antirheumatic Drugs: Efficacy and Safety Through 5 Years (SELECT-NEXT) - doi.org/10.3899/jrheum.2023-1062 Patients With Psoriatic Arthritis–Related Enthesitis and Persistence on Tofacitinib Under Real-World Conditions - doi.org/10.3899/jrheum.2024-0016 Cut-Offs for Disease Activity States in Axial Spondyloarthritis With Ankylosing Spondylitis Disease Activity Score (ASDAS) Based on C-Reactive Protein and ASDAS Based on Erythrocyte Sedimentation Rate: Are They Interchangeable? - doi.org/10.3899/jrheum.2023-1217 When Should I Get My Next COVID-19 Vaccine? Data From the Surveillance of Responses to COVID-19 Vaccines in Systemic Immune-Mediated Inflammatory Diseases (SUCCEED) Study - doi.org/10.3899/jrheum.2023-1214

Dr. Steven Lome dives deep into the intricacies of C-reactive protein (CRP) as an inflammatory marker, emphasizing its role in assessing heart disease risk. He underscores the distinction between regular and high-sensitivity CRP tests, exploring their implications in relation to LDL cholesterol levels. Additionally, Dr. Lome touches on various factors affecting CRP levels and stresses the importance of a balanced, plant-based diet in managing inflammation. With insightful references to current clinical trials and personal practices, he provides a comprehensive view on heart health, cholesterol, and inflammation. #HeartHealth #CRPInsights #PlantBasedDiet

Scientists have been amassing an increasing amount of evidence about the impact of racial discrimination and racial trauma, including how it can have an impact on brain regions involved with threat vigilance and emotional regulation. At the same time, there's evidence that increased engagement in those areas has been linked to increased risk of mental health problems like depression, and they also suspect it could be a vulnerability for brain health issues such as dementia and Alzheimer's disease. Negar Fani is an associate professor in the department of psychiatry and behavioral sciences at Emory University School of Medicine, and she worked with Aziz Elbasheir, a PhD candidate at Emory University in the neuroscience program, on the study. They knew that C-reactive proteins, or CRPs, are a marker of immune activation in the blood.Read their full study here: https://www.nature.com/articles/s41386-023-01737-7 Hosted on Acast. See acast.com/privacy for more information.

Factors influencing C-reactive protein status on admission in neonates after birth.Cao C, Wang S, Liu Y, Yue S, Wang M, Yu X, Ding Y, Lv M, Fang K, Chu M, Liao Z.BMC Pediatr. 2024 Feb 1;24(1):89. doi: 10.1186/s12887-024-04583-8.PMID: 38302903 Free PMC article. As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

Watch Here : https://www.youtube.com/watch?v=kayJxk_fwMs Website: https://vigoroussteve.com/ Consultations: https://vigoroussteve.com/consultations/ eBooks: https://vigoroussteve.com/shop/ YouTube Channel: http://www.youtube.com/user/VigorousSteve/ Workout Clips Channel: https://www.youtube.com/channel/UCWi2zZJwmQ6Mqg92FW2JbiA Instagram: https://instagram.com/vigoroussteve/ TikTok: https://www.tiktok.com/@vigoroussteve Reddit: https://www.reddit.com/r/VigorousSteve/ PodBean: https://vigoroussteve.podbean.com/ Spotify: https://open.spotify.com/show/2wR0XWY00qLq9K7tlvJ000 Patreon: https://www.patreon.com/vigoroussteve

In this early pandemic study of COVID-19 confirmed hospitalized patients, researchers found two groups of individuals with biomarker profiles: the first had high fibrinogen levels in relation to C-Reactive proteins (CRP) and the second had an increase in D-Dimers in relation to CRP. These molecules generally increase in relation to CRP; however, here the researchers found that the fibrinogen and D-Dimers increased while the CRP stayed low. These cohorts were associated with higher likelihood of neurological long COVID. Let's review both the findings and the mechanisms. DrBeen: Medical Education Onlinehttps://www.drbeen.com/ FLCCC | Front Line COVID-19 Critical Care Alliancehttps://covid19criticalcare.com/ URL list (Sep. 7, 2023) Acute blood biomarker profiles predict cognitive deficits 6 and 12 months after COVID-19 hospitalization | Nature Medicinehttps://www.nature.com/articles/s41591-023-02525-y Clotting proteins linked to Long Covid's brain fog | Science | AAAShttps://www.science.org/content/article/clotting-proteins-linked-long-covid-s-brain-fog Physiology, Acute Phase Reactants - StatPearls - NCBI Bookshelfhttps://www.ncbi.nlm.nih.gov/books/NBK519570/#:~:text=Acute%20phase%20reactants%20(APR)%20are,acute%20and%20chronic%20inflammatory%20states. Fibrin Polymerization - an overview | ScienceDirect Topicshttps://www.sciencedirect.com/topics/immunology-and-microbiology/fibrin-polymerization#:~:text=Cross%2Dlinked%20fibrin%20is%20an,that%20stabilizes%20the%20platelet%20plug.&text=Thrombin%20also%20activates%20a%20thrombin,%E2%80%9CFibrinolysis%2C%E2%80%9D%20below). Determinants of the onset and prognosis of the post-COVID-19 condition: a 2-year prospective observational cohort study - The Lancet Regional Health – Europehttps://www.thelancet.com/journals/lanepe/article/PIIS2666-7762(23)00143-6/fulltext Role of C-Reactive Protein at Sites of Inflammation and Infection - PMChttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908901/#:~:text=Evidence%20suggests%20that%20CRP%20is,NO%20release%2C%20and%20cytokine%20production. Screening Tests in Haemostasis:Fibrinogen Assayshttps://practical-haemostasis.com/Screening%20Tests/fibrinogen.html D-Dimers • The Blood Projecthttps://www.thebloodproject.com/cases-archive/d-dimers/d-dimers/ Low-Dose Aspirin and the Risk of Stroke and Intracerebral Bleeding in Healthy Older People: Secondary Analysis of a Randomized Clinical Trial | Geriatrics | JAMA Network Open | JAMA Networkhttps://jamanetwork.com/journals/jamanetworkopen/fullarticle/2807630#:~:text=In%20this%20secondary%20analysis%20of,overall%20risk%20of%20intracranial%20bleeding. Disclaimer:This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only. Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional. dr beenfibrinogenflccclong covidlong story short

Commentary by Dr. Valentin Fuster

In this episode of the School of Doza podcast, Nurse Doza discusses the importance of taking control of your health and provides valuable information on five blood tests you should be getting each year. With his passion for helping others, Nurse Doza aims to empower his listeners to optimize their health and make informed decisions. Don't forget to check out the Nurse Doza YouTube channel for video content and subscribe to the newsletter for bi-weekly updates.    TIMESTAMPS: 00:00 START 02:11 HSCRP: Marker of Inflammation. 04:28 Inflammatory diseases like autoimmune issues. 07:09 Fasting insulin and inflammation. 10:37 Athletes and their diet. 14:45 Problems with insulin and longevity. 19:23 Your body's response to stress. 23:49 Low DHS and mortality. 26:05 Chronic autoimmune disorders and infections. 28:06 Homocysteine and its implications. 31:08 High homocysteine and its impact.   Are you looking to optimize your health and wellness even further? Meet Bliss, a scientifically-formulated supplement designed to fill the gaps in your diet and complement your daily health routine. Take a proactive step with Bliss, and feel the difference it can make. Click the link to order your Bliss supplement now and start your journey towards enhanced well-being https://www.mswnutrition.com/products/bliss   SHOW NOTES FIRST: High-Sensitivity C-Reactive Protein (hs-CRP) High-sensitivity C-reactive protein (hs-CRP) is a critical marker of inflammation. This biomarker can predict the likelihood of myocardial infarction, stroke, peripheral arterial disease, and sudden cardiac death in healthy individuals with no prior history of cardiovascular disease. In addition, hs-CRP can also predict recurrent events and death in patients with acute or stable coronary syndromes[^1^]. Studies have shown that hs-CRP levels were significantly higher in patients with depression than in control subjects, indicating low-grade inflammation[^2^]. Furthermore, CRP, the protein that hs-CRP measures, binds phosphocholine (PC) with high affinity in the presence of calcium (Ca++)[^3^].  Studies:  [^1^]: High-sensitivity C-reactive protein: clinical importance [https://pubmed.ncbi.nlm.nih.gov/15258556/] [^2^]: Elevated C-Reactive Protein in Patients With Depression, Independent of Genetic, Health, and Psychosocial Factors: Results From the UK Biobank [https://pubmed.ncbi.nlm.nih.gov/33985349/] [^3^]: C-Reactive Protein (CRP) and Autoimmune Disease: Facts and Conjectures [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2486333/] [^4^]: Therapeutic Lowering of C-Reactive Protein [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7901964/] SECOND: Fasting Insulin Fasting insulin is a critical test for detecting insulin resistance, which is associated with an exacerbated risk of hypertension in the general population[^2^]. Elevated fasting insulin concentrations can result from factors like neuroinflammation, oxidative stress from mitochondrial dysfunction, or dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis[^5^]. Additionally, leptin, another hormone related to insulin, has been found to correlate with various health conditions like cardiovascular disease, hypertension, stroke, dyslipidemia[^5^]. Studies: [^2^]: Fasting insulin, insulin resistance and risk of hypertension in the general population: A meta-analysis [https://pubmed.ncbi.nlm.nih.gov/27836689/] [^3^]: Effects of Intermittent Fasting on the Circulating Levels and Circadian Rhythms of Hormones [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419605/] [^4^]: Circulating adiponectin levels associate with inflammatory markers, insulin resistance and metabolic syndrome independent of obesity [https://pubmed.ncbi.nlm.nih.gov/18253163/] [^5^]: Peripheral versus central insulin and leptin resistance: Role in metabolic disorders, cognition, and neuropsychiatric diseases [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642294/] [^6^]: Partial Leptin Reduction as an Insulin Sensitization and Weight Loss Strategy [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6774814/] THIRD: DHEA-S (Dehydroepiandrosterone Sulfate) DHEA and its sulfated metabolite DHEA-S are endogenous hormones secreted by the adrenal cortex. These hormones are essential for the production of sex hormones, including androgens (testosterone and androstenedione) and estrogen[^1^]. Studies have shown that low DHEA-S levels have been associated with all-cause mortality, cardiovascular, and inflammatory diseases[^3 ^]. Furthermore, a recent systematic review and meta-analysis have pointed out that DHEA could serve as a valuable biomarker for stress[^14^]. Studies: [^1^]: DHEA and DHEA-S: a review [https://pubmed.ncbi.nlm.nih.gov/10197292/] [^2^]: Dehydroepiandrosterone [https://www.mountsinai.org/health-library/supplement/dehydroepiandrosterone] [^3^]: Very High Dehydroepiandrosterone Sulfate (DHEAS) in Serum of an Overweight Female Adolescent Without a Tumor [https://www.frontiersin.org/articles/10.3389/fendo.2020.00240/full] [^4^]: Low serum DHEA-S is associated with impaired lung function in women [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280766/] [^14^]: DHEA as a Biomarker of Stress: A Systematic Review and Meta-Analysis [https://www.frontiersin.org/articles/10.3389/fpsyt.2021.688367/full] FOURTH: Vitamin D Vitamin D is a group of fat-soluble secosteroids that play a vital role in calcium homeostasis and bone health. Vitamin D insufficiency has been linked to various health problems, including cardiovascular disease, certain cancers, cognitive decline, and severe infections such as COVID-19[^7^]. There's also evidence suggesting that vitamin D can modulate the immune system and has anti-inflammatory properties[^8^]. Studies: [^7^]: Vitamin D and Cardiovascular Disease [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132695/] [^8^]: A Review of the Critical Role of Vitamin D in the Functioning of the Immune System and the Clinical Implications of Vitamin D Deficiency [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166406/] [^9^]: Vitamin D and depression: a systematic review and meta-analysis comparing studies with and without biological flaws [https://www.ncbi.nlm.nih.gov/pubmed/24603370/] [^10^]: Effect of Vitamin D Supplementation on the Incidence of Gestational Diabetes [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438452/] FIFTH: Omega-3 Index Omega-3 Index, expressed as a percentage, measures the amount of EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) in red blood cell membranes. It's considered a reflection of a person's omega-3 fatty acid status and has been correlated with various health outcomes. High levels of omega-3s are associated with a lower risk of death from heart disease[^11^]. In addition to cardiovascular benefits, omega-3 fatty acids also have anti-inflammatory properties and are crucial for brain health[^12^]. Studies: [^11^]: Omega-3 Index and Sudden Cardiac Death [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664414/] [^12^]: Omega-3 Fatty Acids and Inflammation [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257651/] [^13^]: Omega-3 fatty acids and mood disorders [https://www.ncbi.nlm.nih.gov/pubmed/18640689/] [^15^]: Fish consumption, omega-3 fatty acids and risk of heart failure: A meta-analysis [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499005/]

Objective: Determine the significance and clinical use of C-Reactive Protein in clinical practice   Lab Test Name: C-Reactive Protein – CRP   Description: C-reactive protein (CRP) is made in the liver in response to inflammation Measures CRP in the blood Increases quickly Decreases quickly   Indications: Monitor or Identify: Inflammation in the body Appendicitis Pelvic Inflammatory Disease (PID) Crohn's Ulcerative Colitis Rheumatoid Arthritis (RA) Lupus (SLE – Systemic Lupus Erythematosus) Evaluate: Coronary Artery Disease (CAD) Cholesterol level – atherosclerosis   Normal Therapeutic Values: Normal –

Dr. Jack Wolfson discusses his Paleolithic approach to Cardiology with Dr. Ben Weitz. [If you enjoy this podcast, please give us a rating and review on Apple Podcasts, so more people will find The Rational Wellness Podcast. Also check out the video version on my WeitzChiro YouTube page.]    Podcast Highlights 2:13  Conventional cardiology tells us that consuming saturated fats, such as found in red meat and butter, raises LDL cholesterol levels, which leads to cholesterol plaques forming in our arteries, which leads to heart attacks and strokes.  Dr. Wolfson believes that this view is completely wrong, since it is based on flawed studies that supposedly show that cardiovascular disease is caused by saturated that it can be cured with pills and procedures. 4:09  Advanced lab testing.  To diagnose cardiovascular disease, there are better tests than just the standard lipid profile.  Dr. Wolfson believes that HsCRP (High sensitivity C-Reactive Protein) is the most important marker to assess overall health, since it is the best marker for inflammation. But if it is elevated, you have to ask why are you inflamed and what can you do about it?  The reason that the body lays down cholesterol in the arteries as plaque is to protect the artery walls against inflammation, like putting spackle on the wall to make the wall smooth if there is a hole or irregularity. If we correct the reason for the inflammation, that is how we will end heart disease. 8:27  Dr. Wolfson does not recommend the coronary artery calcium scan, because he does not like exposure to radiation. He does like to look at advanced lipid analysis, lipoprotein (a), homocysteine, and uric acid. He also likes to test for intracellular vitamins and minerals and omega-3s, including intracellular vitamin K2. 10:02  Dr. Wolfson currently prefers using Vibrant America lab and some of the panels that he likes include the Leaky Gut Panel, which includes looking for gluten sensitivity, that includes the anti-actin antibody, which just shows that your immune system is attacking the actin protein found in all muscular tissue.  And all cells that divide contain actin protein, including the smooth muscle of the arteries.  Dr. Wolfson also likes running the toxic testing (Total Tox Burden) that includes heavy metals, environmental toxins like pesticides, phalates, parabens, VOCs, and plastics, and mold mycotoxins. 15:13  Dr. Wolfson does not like coronary calcium scans and he also does not recommend CT angiograms or nuclear stress tests because he is against radiation. He also feels like these scans get patients in the door and then when they find blockages, they are sent for a stress test and then they end up needing a stent or bypass surgery, even though they may have no symptoms and these procedures do not prevent heart attacks or save lives.  The conventional thinking is that you have a 30, 50, 70% blockage that was discovered by testing and you do an angioplasty and stent and you are saving them from a heart attack. But you actually take an unstable plaque and may be making it unstable. And then you find yourself on a bunch of pharmaceuticals that you were not on before and you have not done anything to address the cause of the problem. Stents do help reduce cardiovascular symptoms like chest pain and shortness of breath.  Dr. Wolfson's advice to people is to eat well, live well, think well. Part of living well is avoiding electromagnetic fields and manmade radiation exposure. Radiation causes heart disease, cancer, and dementia. 20:17  Diet.  While there is much disagreement about which diet is best, we should all agree to eat organic food so we can get the chemicals out of our food.  Dr. Wolfson believes that wild seafood is healthy and will provide good levels of the omega-3 fatty acids, DHA and EPA. He also recommends nose to tail, grass-fed, grass-finished, pasture raised animals, including the organs, liver, heart, et cetera.  Dr.

In this month's podcast, Journal of Investigative Medicine Social Media Editor John Dickinson, MD, PhD, University of Nebraska Medical Center, welcomes guest, Dr. Stephen Farrell, senior investigator in the research division at the Cooper Institute in Dallas, Texas, for a discussion of the article "Associations among cardiorespiratory fitness, C-reactive protein, and all-cause mortality in men and women," published in the April 2023 issue of the Journal of Investigative Medicine.

With Carl Orringer, University of Miami Miller School of Medicine - USA & Michael Albosta, Jackson Memorial Hospital, Miami - USA Link to paper Link to editorial

How much autonomy do you want over your Vitality Span?  Proactive strategies, rather than the reactive medical model, will empower you to feel better, look better, and more fully enjoy the relationships in our lives. This is information that can increase your vitality, improve your relationships, and take the stress out of being healthy!

C-reactive protein has an extremely diverse causality, can be difficult to interpret, and shouldn't be used as an isolated test. Knowing your numbers is key for all disease prevention, and this is another avenue to explore for checking overall wellness. Article by Anne O. Rice, BS, RDH, CDP, FAAOSH   Read Article HERE: https://www.rdhmag.com/pathology/oral-systemic/article/14287624/call-in-the-troops-creactive-protein-is-on-the-loose

Get a free nursing lab values cheat sheet at NURSING.com/63labs   Objective: Determine the significance and clinical use of C-Reactive Protein in clinical practice   Lab Test Name: C-Reactive Protein – CRP   Description: C-reactive protein (CRP) is made in the liver in response to inflammation Measures CRP in the blood Increases quickly Decreases quickly   Indications: Monitor or Identify: Inflammation in the body Appendicitis Pelvic Inflammatory Disease (PID) Crohn's Ulcerative Colitis Rheumatoid Arthritis (RA) Lupus (SLE – Systemic Lupus Erythematosus) Evaluate: Coronary Artery Disease (CAD) Cholesterol level – atherosclerosis   Normal Therapeutic Values: Normal –

Erin Palinski-Wade, RD, CDCES, LDN, CPT, joins The Huddle to discuss two key nutrients for blood glucose management and overall health: fats and fiber. Many adults with or at risk for type 2 diabetes aren't getting adequate amounts of these nutrients. In this episode, we dive into the health benefits of dietary fats and fiber, highlight some nutrient-dense sources, like fresh avocado, and share some practical ways individuals can increase their intake of these nutrients.Disclosure: This episode is sponsored by Fresh Avocados – Love One Today®. Love One Today® is a leading source of the healthiest reasons and tastiest ways to enjoy fresh avocados. A science-based resource, it provides turnkey solutions that make it easy for health professionals to stay on top of the latest research and confidently recommend avocados. Episode Notes:Love One Today: https://loveonetoday.com/2020-2025 Dietary Guidelines For Americans: https://www.dietaryguidelines.gov/Schoeneck, Malin, and David Iggman. “The effects of foods on LDL cholesterol levels: A systematic review of the accumulated evidence from systematic reviews and meta-analyses of randomized controlled trials.” Nutrition, metabolism, and cardiovascular diseases : NMCD vol. 31,5 (2021): 1325-1338. doi:10.1016/j.numecd.2020.12.032Reynolds, Andrew N et al. “Dietary fibre and whole grains in diabetes management: Systematic review and meta-analyses.” PLoS medicine vol. 17,3 e1003053. 6 Mar. 2020, doi:10.1371/journal.pmed.1003053Dana E. King, Arch G. Mainous, Thomas A. Buchanan, William S. Pearson; C-Reactive Protein and Glycemic Control in Adults With Diabetes. Diabetes Care 1 May 2003; 26 (5): 1535–1539. https://doi.org/10.2337/diacare.26.5.1535Zhang X, Xiao D, Guzman G, Edirisinghe I, Burton-Freeman B.  “Avocado Consumption for 12 Weeks and Cardiometabolic Risk Factors: A Randomized Controlled Trial in Adults with Overweight or Obesity and Insulin Resistance.” The Journal of nutrition vol. 152,8 (2022): 1851-1861. doi:10.1093/jn/nxac126Zhu, Lanjun, Yancui Huang, Indika Edirisinghe, Eunyoung Park, and Britt Burton-Freeman. 2019. "Using the Avocado to Test the Satiety Effects of a Fat-Fiber Combination in Place of Carbohydrate Energy in a Breakfast Meal in Overweight and Obese Men and Women: A Randomized Clinical Trial" Nutrients 11, no. 5: 952. https://doi.org/10.3390/nu11050952Resources:Avocado nutrition 101How to choose and prepare an avocadoHow to cut, slice, peel and pit an avocadoHow to ripen avocados fasterHow to store avocadosAccredited Podcast: Avocados, Satiety and Mindful Eating in Diabetes with Erin Palinski-Wade, MS, RDN, CDEEducational Handout: Effects of avocado on LDL cholesterolNutrition Therapy for Adults with Diabetes or Prediabetes: A Consensus Report

• Host Austin Beason, MD • Guest interview Andrew Schoenfeld, MD, MSc, FAAOS discussing his review article “C-reactive protein-Albumin Ratio is Associated with Post-Treatment Complications in the Setting of Spinal Epidural Abscess” from the September 1, 2022 issue • Article summarized from the September 1, 2022 issue (https://journals.lww.com/Jaaos/toc/2022/09010) o Research article “Level-specific Perioperative and Clinical Outcome Comparison: Cervical Disk Replacement Versus Anterior Cervical Diskectomy and Fusion at C5-C6 in Patients With Myeloradiculopathy” • Article summarized from the September 15, 2022 issue (https://journals.lww.com/Jaaos/toc/2022/09150) o Review article “Revisiting the Classic Open Fracture Studies to Correct Misperceptions and Errors” Follow this link to download these and other articles from the September 1, 2022 issue of JAAOS (https://journals.lww.com/Jaaos/toc/2022/09010) and the September 15, 2022 issue of JAAOS (https://journals.lww.com/Jaaos/toc/2022/09150). The JAAOS Unplugged podcast series is brought to you by the Journal of the American Academy of Orthopaedic Surgeons and the AAOS Resident Assembly. In addition, this podcast is brought to you by our sponsor, Robin. Visit robin.co/JAAOS to discover the difference ambient virtual scribing can have on your practice. Disclaimer: Neither AAOS nor JAAOS are associated with Robin or any products or services advertised. AAOS does not endorse the advertiser or its products or services.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.08.30.505953v1?rss=1 Authors: Liu, F., Su, S., Zhang, L., Fang, Y., Cui, H., Sun, J., Xie, Y., Ma, C. Abstract: Background: Neuropathic pain is difficult to treat in clinical practice, and the underlying mechanisms are insufficiently elucidated. Previous studies have demonstrated that Fc{gamma} receptor I (Fc{gamma}RI) is expressed in the neurons of the dorsal root ganglion (DRG) and may be involved in chronic pain. Methods: Chronic constriction injury (CCI) was used to induce neuropathic pain in rats. Primary neuron-specific Fcgr1 conditional knockout (CKO) rats were established by crossing rats carrying a Fcgr1loxP+/+ with the PirtCRE+ line. Behavioral and molecular studies were conducted to evaluate the differences between wild-type and CKO rats after CCI. Results: We first revealed that CCI activated neuronal Fc{gamma}RI-related signaling in the DRG. CCI-induced neuropathic pain was alleviated in CKO rats. C-reactive protein (CRP) was increased in the DRG after nerve injury. Intraganglionic injection or overexpression of the recombinant CRP protein in the DRG evoked pain accompanied and activated neuronal Fc{gamma}RI. CRP-evoked pain was significantly reduced in CKO rats. Furthermore, microinjection of native IgG into the DRG alleviated neuropathic pain and the activation of neuronal Fc{gamma}RI-related signaling. Conclusions: Our results indicate that the activation of neuronal CRP/Fc{gamma}RI-related signaling plays an important role in the development of pain in CCI. Our findings may provide novel insights into the neuroimmune responses after peripheral nerve injury and might suggest potential therapeutic targets for neuropathic pain. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer

This week, please join authors Paul Ridker and Eric Van Belle, editorialist Robert Harrington, and Guest Editor Allan Jaffe as they discuss the original research articles "Effects of Randomized Treatment With Icosapent Ethyl and a Mineral Oil Comparator on Interleukin-1β, Interleukin-6, C-Reactive Protein, Oxidized Low-Density Lipoprotein Cholesterol, Homocysteine, Lipoprotein(a), and Lipoprotein Associated Phospholipase A2: A REDUCE-IT Biomarker Substudy" and “Cerebral Microbleeds During Transcatheter Aortic Valve Replacement: A Prospective Magnetic Resonance Imaging Cohort” and the editorial "Trials and Tribulations of Randomized Clinical Trials." Dr. Carolyn Lam:             Welcome to Circulation on the Run, your weekly podcast summary and backstage pass to the Journal and its editors. We're your co-hosts. I'm Dr. Carolyn Lam, Associate Editor from the National Heart Center, and Duke National University of Singapore. Dr. Greg Hundley:           And I'm Dr. Greg Hundley, Associate Editor, Director of the Pauley Heart Center at VCU Health in Richmond, Virginia. Dr. Carolyn Lam:             It's double feature time Greg. We've got two totally unique and interesting papers that we'll be discussing. The first, a biomarker substudy from the REDUCE-IT trial, that is looking at the effects of randomized treatment with icosapent ethyl, versus a mineral oil comparator, on inflammatory biomarkers. Now, don't use roll your eyes at me, because I'm telling you, this has results that you may not expect, and very, very important clinical implications, and implications for clinical trials. The second paper, very much up your alley, Greg, is a prospective MRI study of cerebral microbleeds during TAVR. But okay, enough now to whet your appetite, let's now just first grab coffees, and discuss the other papers and the issue, shall we? Dr. Greg Hundley:           You bet, Carolyn. And how about if I go first? Dr. Carolyn Lam:             Please. Dr. Greg Hundley:           So, Carolyn, my first paper comes from a group of investigators led by Dr. Araz Rawshani from the Institute of Medicine, and it included 715,143 patients with diabetes, registered in the Swedish National Diabetes Register, and compared them with over two million match controls, randomly selected from the general population, to determine the role of diabetes in the development of valvular heart disease, and particularly, the relation with risk factor control. Dr. Carolyn Lam:             Huh? Interesting, diabetes and valve disease. All right. What did they find, Greg? Dr. Greg Hundley:           Right, Carolyn. So they found, that individuals with type one and two diabetes, have greater risk for stenotic lesions. Whereas, risk for valvular regurgitation was lower in type two diabetes. Patients with well controlled cardiovascular risk factors, continued to display higher risk for valvular stenosis, without a clear stepwise decrease in risk between various degrees of risk factor control. So Carolyn, diabetes and a link with valvular heart disease. Dr. Carolyn Lam:             Wow. Really interesting, Greg. Thanks. Well, the next paper is a preclinical study with really interesting clinical implications. Now, we know the human heart has limited capacity to regenerate new cardiomyocytes, and that this capacity declines with age. Now, because loss of cardiomyocytes may contribute to heart failure, it is important to explore how stimulating endogenous cardiac regeneration, to favorably shift the balance between loss of cardiomyocytes and birth of new cardiomyocytes, occurs in the aged heart. Now, these authors, Doctors Rosenzweig, from Massachusetts General Hospital, and Dr. Lee from Harvard University and colleagues, previously showed that cardiomyogenesis can be activated by, guess what? Exercise in the young adult mouse heart. However, whether exercise also induces cardiomyogenesis in aged hearts, however, is not yet known. So in today's paper, the authors aim to investigate the effect of exercise on generation of new cardiomyocytes in the aged heart. And here, we're talking about 20 month old mice, who were subjected to an eight week voluntary running protocol, and age matched sedentary animals who served as controls. Dr. Greg Hundley:           Wow, Carolyn. Really interesting evaluation of exercise on cardiomyogenesis. So what did they find? Dr. Carolyn Lam:             Endogenous cardiomyogenesis can be stimulated by exercise in aged hearts. Comparative global transcriptional analysis further revealed, that exercise and age specific changes occurred in gene programs. The regulator of calcineurin RCAN1.4 was specifically found to be induced with exercise in aged hearts, and was accompanied by reduced calcineurin activity. So what's a take-home message? Exercise induced cardiomyogenesis may counter the increased cardiomyocyte loss and reduced cardio myogenic capacity in elderly patients. Dr. Greg Hundley:           Great, Carolyn. Well from the mail bag, there's an exchange of letters to the editor from Professor Zhou and Veith regarding a prior letter to the editor from Professor Jin and associates, pertaining to the previously published article “SPARC, A Novel Regulator of Vascular Cell Function in Pulmonary Hypertension.” And also, there's a Perspective piece, from Professor Mentz entitled, “Catastrophic Disruptions in Clinical Trials.” Dr. Carolyn Lam:             There's also a Research Letter by Dr. Kumar on [entitled] “von Willebrand Factor Is Produced Exclusively by Endothelium, Not Neointima, in Occlusive Vascular Lesions in Both Pulmonary Hypertension and Atherosclerosis.” There's also this beautiful tour of Cardiology News from the literature, from Tracy Hampton, which ranges from a study linking COVID-19 to higher long term cardiovascular risks, which was published in Nature Med, to uncovering alternative metabolic pathways involving cell fate transitions, published in Nature, to designing an autonomous biohybrid fish, from human stem cell derived cardiac muscle cells, that was published in Science. Wow. Isn't that amazing, Greg? Well, let's get on now though, to our two feature papers. Shall we? Dr. Greg Hundley:           You bet. Welcome listeners, to these two feature discussions on this particular day. And our first feature today, we have with us Dr. Paul Ridker, from Brigham and Women's Hospital in Boston, Massachusetts. Dr. Bob Harrington, from Stanford University in California. And also, Dr. Allan Jaffe, from Rochester, Minnesota. Welcome to you all. And Paul, we're going to start for you. Can you describe for us, the background information that really went into the construct of your study, and what was the hypothesis that you wanted to address? Dr. Paul Ridker: Sure, Greg. So first of all, my thanks to the AHA and the Circulation for publishing this paper, we always want to support the AHA, and we're delighted to be here today for these podcasts. The field of omega-3 fatty acids has been a complicated one for a long time. Epidemiology suggested that, fish consumption would lower cardiovascular risk, and there was a number of trials done. And my friend and colleague here at the Brigham, Deepak Bhatt, was the lead of a very big trial, called REDUCE-IT. Some 8,000 plus patients who received EPA alone, and they got a terrific result. A 25% reduction in their primary endpoint. And this was a New England Journal paper, back in 2019 or so. But another friend of mine, Steve Nicholls, ran another large trial of a combination of eicosapentaenoic acid, or EPA, plus docosahexaenoic acid that's DHA called STRENGTH. And that one showed, really, no benefit. And so, there's been some controversy out there. In any event, when Deepak and his colleagues published their original paper, they said it's interesting, because they got this big risk reduction, but it wasn't apparently due to the triglyceride lowering of the drug. And so, my interest, as many people know, has largely been in inflammation biology. And so we said, well maybe we should just do a test. Well, we said, we'll measure a number of biomarkers that we know were associated with atherosclerosis, some inflammatory, some with coagulation. And so, that was the core hypothesis, was simply to look at some other markers, and see what we might learn. And sometimes, you learn things that you didn't expect. And I think, that goes to the heart of what complicated clinical trials are all about. And I'd also say perhaps, what the roles of surrogate endpoints are, as compared to hard clinical endpoints, and things that make this whole field kind of interesting. Dr. Greg Hundley:           Right. Very nice, Paul. So you mentioned REDUCE-IT, so describe a little bit more for your study. What was the study population, and what was your study design? Dr. Paul Ridker: We were fortunate enough to work with REDUCE-IT investigators, to use their biobank. They had put together, again, it's 8,000 plus patients. I think, it was two thirds secondary prevention, one third primary prevention. And when they received the combination of EPA and DHA, as I said earlier, they had about a 25% reduction in the risk of their primary endpoint, which was cardiovascular death, nonfatal AMI, nonfatal stroke, coronary revascularization, and the like. What we did is, we basically said, "Okay, since the mechanism was uncertain, why don't we go ahead and measure a series of biomarkers?" Things that a lot of us are interested in, homocysteine, LPLa, oxidized LDL, my own interest in inflammation. We measured, IL-1β, we measured, IL-6, we measured CRP. We measured another molecule, Lp-PLA2, that people have been interested in. And the hypothesis, of course, was to see what the drug did, as compared to the comparator did. And the findings were interesting to us, in that, to simplify them, the actual icosapent ethyl arm didn't do much to most of those biomarkers, very little change. But the mineral oil comparator arm had some small to modest effects on all those biomarkers, all of which went up again. Now, some of these effects are pretty small, two to 3% for things homocystine, LPLa. Others were moderate, 10 to 20% increases in oxidized LDL, Lp-PLA2. And the inflammatory markers went up about 25%, sometimes, even a little more. So it's complicated. It's important to point out, that these changes on an absolute scale are relatively small. On a percent scale, they're different. The REDUCE-IT investigators themselves, to their credit, had earlier published that, they saw some increase in LDL cholesterol as well, about 10, 11% in those who had received the mineral oil comparator. So it's not exactly what we thought we were going to find, I guess, is the simplest way to express it. Dr. Greg Hundley:           Very nice. And so, describe for us just a little bit more, any differences in men and women, and what about age? Or for example, premenopausal, postmenopausal women. Dr. Paul Ridker: No, the effects were quite consistent across all various subgroups. It's a very large study. There were, again, 8,000 patients, lots of blood samples been drawn. And I should again, commend the REDUCE-IT investigators, for allowing us to do this work with them. And again, as I point out, sometimes you find things out that weren't what you expected. And the hard part, I was glad this got tossed over with Dr. Harrington, is sort to figure out well, what's it really mean? Because again, as a clinical trial list, I will say, my instincts are to trust the primary endpoint of the trial. That's what they did. They're going to go out and lower heart attacks and strokes. And then, here we are a couple years later, trying to figure out what the mechanism might be, and just came across some puzzling results. Dr. Greg Hundley:           Very nice. Well, next listeners, we're going to turn to the editor that actually processed this manuscript, Dr. Allan Jaffe. Allan, what drew you to this particular article? Dr. Allan Jaffe:   Well, I was asked to be a guest editor this week, by the Journal, because of some conflicts that were intrinsic to the editorial board. And since I have an interest in biomarkers, and had for a long time, it made perfect sense for me to become involved. I was particularly interested in this particular area, because I was aware that there were these two trials that had found different endpoints, and that there were some controversy as to what the mechanisms might be by which these effects could occur. And so I was pleased to get involved. And I think it's a compliment to the REDUCE-IT investigators, and to Dr. Ridker, that they were willing to put the data out there so that everybody could see it. And we could then begin to look. So it was of interest to me. I thought it was important to the field, to get really good reviewers who would be, make sure that the data that would eventually be published was clear, so that readers would understand it. And so that, at the end, we'd be able to at least, come to some conclusions that we could end up having an expert in clinical trials. And I thought about Bob Harrington, right from the beginning, might be able to comment on. Dr. Greg Hundley:           Very nice. Well, Bob he's setting you up here nicely, both Paul and Allan, to really help us put these results in perspective with other studies that have been performed in this space. What are your thoughts? Dr. Robert Harrington:   So first off, Greg, thanks for having me. And Allan, thanks for inviting me to review and comment on the paper. As both Allan and Paul have indicated, that I've spent the last 30 plus years doing clinical trials of all sizes. Very small, where we try to understand mechanisms, and very large, where what we're trying to understand is clinical outcomes. And I've been intrigued in this field, because of the inconsistency of the data across the field. Where in some trials, Paul had indicated this STRENGTH, there seemed to be no effect of omega-3 fatty acids, and in REDUCE-IT, there was quite a pronounced effect of the test agent. And so, when one sees discordance in a field, one tries to understand, well, why might that be? And so in the editorial, I took the position that, well, what are we trying to do in clinical trials? And in outcomes trials, we're trying to figure out what matters to patients. Do they live longer? Do they feel better? Do they avoid bad stuff happening to them? Like having to undergo revascularization procedure. So you're trying to do things that are really clinically meaningful, but that doesn't say that you're also not trying to understand mechanism. And as Allan said, there have been some questions raised. And so, trying to understand mechanism in the edit in trials can be quite useful, not just to understand that trial results, but to really form hypothesis for a field going forward. And so, I took the approach of, we learn things from different trials, and sometimes we learn things in the same trial. Meaning that, there's mechanistic work embedded in the large trial. One of the most famous examples of this, in the GUSTO trial 30 years ago, we learned through the mechanistic substudy, that it was rapid reprofusion TIMI-3 establishment of TIMI-3 flow, that really explained the difference between TPA and streptokinase. So I was very intrigued by how we might use these data to explore the results. And I find the findings fascinating, as Paul said. It is complicated, but it raises a really fundamental issue in clinical trials. There's an assumption in a placebo control trial, that because randomization is allowing you to balance everything, except for the randomized treatment groups, and therefore, that comparison has causal information in it. There's an underlying assumption that's really important. And that is, that the placebo is inert. That it has no biological effect of its own. Well, that assumption was violated here. The placebo is not inert in this clinical trial. Now, the investigators, I think to their credit, have said, "Well, this is small, probably doesn't matter." And that might be right, but it also may be wrong. And you can't just say, well, it doesn't matter, these are small effects. As Paul said, some of the effects are small, some are medium, some are large. So what explains it? And I made a point in the editorial, you could model all of this. If you get 5% of this, and 10% of this, and 20% of this, you could make some assumptions and say, well, the magnitude of the benefit was so great that it couldn't have been overcome by this. But that's just modeling, and there's uncertainty. So for me, as a trialist, and somebody who really believes in using evidence to guide practice and to guide public policy, I think there's uncertainty here. It's likely that the treatment effect is not as large as was observed, but how large is it? And how large is important? And how large might we want to consider to put into our practice guidelines? I think all of those open questions, particularly in a field where there is inconsistency across trials, in terms of the observation of the outcome. So my conclusion is, we need more work. We need another trial, if we really want to understand this. And we need to use an inert placebo, to really understand what the contribution was. I'd like nothing better to see that it didn't matter. But I can't say that it doesn't matter because I don't know. Dr. Greg Hundley:           Well, listeners, boy, we've got kind of some interest here in that an unexpected result. So Paul, it's nice doing an interview like this listeners, because each speaker sets up the next one. Paul, Bob is saying, well, what should we do next to clarify the results here? So maybe we'll go through each of you, and start with Paul. Just describe for us, what do you think is the next study that we need to perform? Dr. Paul Ridker: Well, Greg, it's a really interesting issue. We saw it, as authors, to write as neutral a paper as we could possibly write, and sort of do our academic job and say, here are the data. And I think we did it that way because, we don't really know what the interpretation should be. On the one hand, you have a very big beneficial result, which is great for patients. And there's a prior clinical trial called JELIS, which was open label, the same drug, and also got a large benefit. And we were trying to figure out mechanism. That being said, as Bob pointed out, I think what we stumbled into is some level of uncertainty. And the question is, how uncertain would it be, and does it matter in the big picture? Allan was interesting, because the Journal asked us to use the word comparator, rather than placebo. Now this was designed as a placebo controlled trial, but our paper uses the word comparator, because of the possibility, that as Bob Harrington points out, it may not be totally inert. So the writing of this was quite carefully done. I think, at the end of the day, my REDUCE-IT colleagues, who I have great respect for, and really worked terribly hard to do the main trial, understandably feel, that the trial would've showed, and I have a lot of sympathy for that, because it's the hard endpoints we should go with. On the other hand, I have sympathy with the idea that it never hurts to have more data. And if there could be a way to have a second trial, and I might change the population a little bit, maybe I'd do it in true primary prevention. This was one third primary prevention. My colleague, Joanne Manson had done her, she had a trial where they showed some potential benefit in the black populations. Maybe you might over sample some minority groups. But just the pragmatic issues here, make it tough to have a second trial. And so, uncertainty is just part of what we, as physicians, have to learn to live with. Dr. Greg Hundley:           Allan, turning to you. What do you think is a next study to perform in this space? Dr. Allan Jaffe:   Well, I think what Paul has said is correct. That it would be very hard to generate enthusiasm funding for a large trial. But it might not be nearly as difficult to begin to explore the effects of the mineral oil comparator, versus the active agent, versus perhaps, another potential placebo, and see over time what happens in primary prevention patients, as a way of beginning to put some context around what these results might mean. So for example, it could turn out that, the active agent actually kept the values from rising as they normally would've, and mineral oil had no effect at all. Alternatively, mineral oil may well have been a negative. It had a negative effect. And I think, those are the sorts of questions that could be explored reasonably in the short term, without doing another multimillion dollar randomized trial. Dr. Greg Hundley:           And Bob, your thoughts. Dr. Robert Harrington:   Well, and I mentioned this in the editorial, Greg. I didn't make my recommendation lightly. I know that these trials are expensive. I know these trials take a great deal of time, a great deal of energy. And I know that the REDUCE-IT investigators worked enormously hard over the years to get this done. So I don't say tritely, "Oh, just do another trial." But if you think about the magnitude of the public health issue here, there are millions of people to who this kind of therapy might apply globally. And so, shouldn't we be more certain than less certain, if we want to include it, for example, in ACC/AHA guidelines? I would say, the answer to that is yes. And so, I think of it as, okay, let's make some assumptions. Let's assume, that the effect that was observed in JELIS and REDUCE-IT, is the true effect. That's ground truth. Well, there are different study designs one might think about, from an analytic perspective, using Bayesian statistics, as opposed to frequency statistics. One might think about an intense interim analysis plan, to understand where the data are going, and be able to pull in the prior data for evaluation. I would advise getting a smart group of people together, who spend their lives thinking about trials in the atherosclerotic space, and the REDUCE-IT team is pretty darn good, and say, "How could we do this efficiently?" I do think, there's enough uncertainty that it would be ethical, from an equipoise perspective, to include high risk patients in a second evaluation, because we do have uncertainty. And if we really want to nail this down, I think we could look at high risk patients with hypertriglyceridemia, and try to use some interesting design issues, and some interesting analytical issues, to try to reduce the sample size, lot of attention in interim analyses, to try to answer the question. I'd like, as I said, nothing better to say, "Oh look, REDUCE-IT was the truth." This next trial is consistent. That'd be, to me, a terrific outcome of this. On the other hand, if you said to me, "Well, the effect's not 25%, it's more in the 15% range." Well, maybe then we think about how we apply it to our patients a little differently, maybe a little more cautiously. So I don't make the recommendation lightly, as I said, but I do think that there are some conversations that could be had, being respectful of the effort and the expense that goes into these kind of things. To try to answer the question efficiently. Dr. Greg Hundley:           Very nice. Well listeners, we want thank Dr. Paul Ridker, from Brigham and Women's Hospital, Dr. Bob Harrington from Stanford University, Dr. Allan Jaffe, from the Mayo Clinic, for bringing us the results of a substudy of the REDUCE-IT trial, that assessed a variety of serum biomarkers, pertaining to systemic inflammation, and highlighting uncertainty around the mechanism regarding the efficacy of icosapent ethyl, that's been used previously for primary or secondary prevention of cardiovascular events. And next listeners, we are going to move to our second feature discussion and review some data pertaining to microbleeds in the central nervous system, during and after TAVR procedures. Welcome listeners, to our second feature discussion on this August 2nd. And we are going to explore some of the world of TAVR and its potential complications. And we have with us today, Dr. Eric Van Belle, from Lille, France. And also, Dr. Manos Brilakis, from Minneapolis, Minnesota. Welcome gentlemen. And Eric, we'll start with you. Can you describe for us a little, the background information that you use to assemble and construct your study, and describe, or list for us, the hypothesis that you wanted to address? Dr. Eric Van Belle:           Yes. Thanks a lot for the question. So we knew for many years, that some of the complication of the TAVR procedure relate to the brain. And it has been described by many others, that there were some complication in the brain of patient undergoing TAVR. And there was no previous investigation on potential bleeding or microbleeding in this population. And on the other side, there are previous publication on, of course, initially chronic microbleeding, in patient with some of, let's say, disease in the brain, but also, a possibility of acute microbleeding. And especially, in some interesting population relating to the TAVR feed, that is patient with valve disease, patient with endocarditis, or patient with assist device. In this population, microbleedings, acute microbleeding, have been described. And what is interesting, if you look at all these populations, these are population in which the Von Willebrand factor has been impacted and modified, and could be one of the reason of the microbleeding. And one of the similar feature of the patient with aortic stenosis that undergo TAVI, or TAVR, that are patient with indeed also, this kind of Von Willebrand disease. So if we put everything together that is previously, we only looked at antibody complication in those population, and that Von Willebrand disease, which is present in patient with aortic valve stenosis, could promote a bleeding, in particular, bleeding in the brain. We decided to look at the potential appearance of microbleeding, in patient undergoing TAVR procedure. Dr. Greg Hundley:           Very nice. And Eric, can you describe for us, your study design, and who was your study population? Dr. Eric Van Belle:           Yes. So basically, the study population is a basic population of patient undergoing TAVI. Just to make sure that one of the difficulty of this study, was to conduct and perform an MRI, a brain MRI, before the procedure, and as short as possible after the procedure, within three days, which is logistically challenging. And also, to make sure that we keep most of the population to undergo the MRI, we had to exclude patient with a high risk of pacemaker, or patient with pacemaker that could not undergo the MRI. But basically, without this, it's just a regular population. And if we indeed, compare to some of the previous work I was mentioning, about describing the acute MRI, it was important for us to make sure, or to be as sure as we could get, that indeed, this microbleeding, if we observe them, could be related to the procedure. And it means that, the MRI, after the procedure, should be done as short as possible. And also, that an MRI, a baseline MRI, should be performed. Because we know, that in this population, you could have some microbleedings also observed before starting the procedure. Dr. Greg Hundley:           So a cohort study design where MRIs are performed before, and then very soon after, TAVR procedures. So Eric, what did you find? Dr. Eric Van Belle:           So what we observed, the first thing that we confirmed was indeed, that in this population of that age, that is patient around 80 years old, when we do the baseline MRI, you find in about one out of four patients already, some microbleedings. And this was expected, and it is very similar to what is expected in this kind of population. But what was indeed more striking, that when we repeated the MRI after three days, we observed another 23% of patient with a new microbleedings that were observed. This is indeed the most important observation. What was also important that, the patient with microbleedings, and the location of the microbleedings, were not related to the cerebellum brain, because indeed we could observe some cerebellum arise in this population, as it is expected. And there was no relation between the two. So it's also, an important observation, suggesting that this microbleeding are not hemorrhagic transformation of cerebellum brain, for instance. And we also observed that, the risk of microbleeding, or the chance to observe the microbleeding, was increased when the procedure was longer. And also, when the total duration of anticoagulation was longer, we also observed that, when the procedure was, when we used protamine at the end of the procedure, the risk of microbleeding was less. And also, importantly, the status of the Von Willebrand factor, and indeed, an alteration of the multimer of Von Willebrand factor, was also associated with the risk of microbleeding in this population. Dr. Greg Hundley:           Very nice. So in this cohort of 84 individuals, average age around 80, undergoing TAVR procedure, and about 50/50 men and women, you had several factors. Prior history of bleeding, amount of heparin, absence of protamine, all indicating a higher risk of these microbleeds. So very practical information. Well, Manos, you have many papers come across your desk. What attracted you to this particular paper? And then secondly, how do we put these results really, in the context of maybe other complications that can occur during or after TAVR procedures? Dr. Emmanouil Brilakis: Yes, thanks so much, Greg. And also, congratulations Eric, for a wonderful paper, and thanks for sending it to circulation. I think, with increasing the number of targets, as you know, TAVR now is becoming the dominant mode for treating severe aortic stenosis. Safety is of paramount importance. And even though there's been a lot of progress, we still have issues with the safety of the procedure. So understanding how can make it safer is very important. And I think, what was unique in this paper, again, congratulations for creating this study, is that it opens a new frontier. We worry about stroke. We're all very worried about the stroke, and having the patient have a permanent neurologic damage during the procedure. But there may be more to it than the classic embolic stroke. And I think, this study opens actually, a new frontier with the micro cerebral bleeds. Now we don't completely understand, despite the study, we don't understand the functional significance from this. And I think, that's one of the areas that will need further research. But I think, trying to understand what causes them, and preventing those microbleeds, would have a very important role in the future, for making TAVR even safer than it is. Dr. Greg Hundley:           Very nice. Well, Manos, you really lead us into the kind of the next question. So Eric, what do you see as the next study to be performed in this sphere of research? Dr. Eric Van Belle:           Again, to me, and to follow with the comment of Manos, we need to include, I would say, to solve two questions. We have to solve the question of, what could really impact these microbleedings. And what would be the impact of this microbleeding on the long term outcome of this patient? So it's means that we have to set, as part of the studies that we will design, potentially studies on aortic immolation. Or let's say for instance, we could investigate the role of protamine. It has been suggested that protamine could be something interesting, so it could be tested as part of a randomized study. But this means that, as part of such randomized study on the use of protamine, for instance, you would include a last cohort of patients with MRI after the procedure. And also, a long term follow of the neurological complication, which indeed, is the missing part of our current study. We would need to have a much larger cohort of patients, to be able to reconnect the neurological outcome to the MRI outcome, and also to include this. So let's say, for me, one of the studies we would be interested to perform, is to conduct a study on the use of protamine, which is very simple, randomized, yes or no, and includes brain MRI in this population, as a systematic investigation, which is difficult to conduct. You have to know that it's difficult to do, but it will be very important. And then, to look at the long term neurological outcome. Dr. Greg Hundley:           And I see, Eric, you mentioned the long term, because really in the short term, so within six months, you really didn't see any changes in neurological functional outcome or quality of life. So Manos, just coming back to you. What do you see is the next study that should be performed in this space? Dr. Emmanouil Brilakis: Yeah, I agree actually, with Eric. The next step is, this was an 80 patient study. Right? It's a very small preliminary data, all that opens a new system for evaluation, we're still a very small number of patients. So having a larger number of patients, I think for me, the key thing is to understand the connection. Does this actually cause neurologic symptoms? What does it mean having a microbleed? I think right now, we're still confused on the study. There was not really much impact on the neurologic status of the patient. So for me, the number one thing is, to understand how it impacts the patient's quality of life, the neurologic status. Perhaps more sensitive studies, neurocognitive studies, to understand exactly how it impacts. And then after doing that, I agree with Eric, if this is a bad, something really bad, then we can find different ways to prevent them from happening. Protamine is one of them during the procedure time, and not be a very feasible one. Or it could be interesting to see if different valves, for example, have different propensity for causing those microbleeds. Dr. Greg Hundley: Very nice. Well listeners, we want to thank Dr. Eric Van Belle, from Lille, France, and also, our own associate editor, Dr. Manos Brilakis, from Minneapolis, Minnesota for bringing this very important study, highlighting that one out of four patients undergoing TAVR has cerebral microbleeds before the procedure. And then, after the procedure, one in four patients develop new cerebral microbleeds. And then, procedural and antithrombotic management, and persistence of acquired Von Willebrand factor defects, were associated with the occurrence of these new cerebral microbleeds. Well, on behalf of Carolyn and myself, we want to wish you a great week, and we will catch you next week On the Run. Dr. Greg Hundley:           This program is copyright of the American Heart Association 2022. The opinions expressed by speakers in this podcast are their own, and not necessarily those of the editors, or of the American Heart Association. For more, please visit ahajournals.org.

On this week's podcast, John Mandrola, MD discusses fish oil, America's heart health, pharmacists and prescribing and statins This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I - Fish Oil - New Biomarker Data Add to Concerns Over REDUCE-IT Trial https://www.medscape.com/viewarticle/976490 - Effects of Randomized Treatment With Icosapent Ethyl and a Mineral Oil Comparator on Interleukin-1β, Interleukin-6, C-Reactive Protein, Oxidized Low-Density Lipoprotein Cholesterol, Homocysteine, Lipoprotein(a), and Lipoprotein-Associated Phospholipase A2: A REDUCE-IT Biomarker Substudy https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.122.059410 - Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia https://www.nejm.org/doi/full/10.1056/nejmoa1812792 - Effect of High-Dose Omega-3 Fatty Acids vs Corn Oil on Major Adverse Cardiovascular Events in Patients at High Cardiovascular RiskThe STRENGTH Randomized Clinical Trial https://jamanetwork.com/journals/jama/fullarticle/2773120 - Effect of icosapent ethyl on progression of coronary atherosclerosis in patients with elevated triglycerides on statin therapy: final results of the EVAPORATE trial https://academic.oup.com/eurheartj/article/41/40/3925/5898836 II - US Heart Health - New AHA Checklist: Only 1 in 5 Adults Have Optimal Heart Health https://www.medscape.com/viewarticle/976519 - Life's Essential 8: Updating and Enhancing the American Heart Association's Construct of Cardiovascular Health: A Presidential Advisory From the American Heart Association https://www.ahajournals.org/doi/10.1161/CIR.0000000000001078 - Status of Cardiovascular Health in US Adults and Children Using the American Heart Association's New "Life's Essential 8" Metrics: Prevalence Estimates from the National Health and Nutrition Examination Survey (NHANES), 2013-2018 https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.122.060911 III - Pharmacist Prescribing - Paxlovid Is Here: A Pharmacist's Prescribing Pearls https://www.medscape.com/viewarticle/973260 - Coronavirus (COVID-19) Update: FDA Authorizes Pharmacists to Prescribe Paxlovid with Certain Limitations https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-authorizes-pharmacists-prescribe-paxlovid-certain-limitations IV - Statin Eligibility - New European Guidelines ‘Drastically' Reduce Statin Eligibility https://www.medscape.com/viewarticle/976715 - Statin Eligibility for Primary Prevention of Cardiovascular Disease According to 2021 European Prevention Guidelines Compared With Other International Guidelines https://jamanetwork.com/journals/jamacardiology/article-abstract/2793729 - Time to Revisit Using 10-Year Risk to Guide Statin Therapy https://jamanetwork.com/journals/jamacardiology/article-abstract/2793732 - Mendelian randomization studies: using naturally randomized genetic data to fill evidence gaps https://doi.org/10.1097/mol.0000000000000247 You May Also Like: Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine The Bob Harrington Show with Stanford University Chair of Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

Howie and Harlan discuss a concerning new COVID-19 variant, the discovery casting doubt on a major fish-oil study, and the need for new models of funding research. Links: “New Omicron subvariant Centaurus could be the most immune-evasive yet, expert warns” “Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia” “Effects of Randomized Treatment With Icosapent Ethyl and a Mineral Oil Comparator on Interleukin-1β, Interleukin-6, C-Reactive Protein, Oxidized Low-Density Lipoprotein Cholesterol, Homocysteine, Lipoprotein(a), and Lipoprotein-Associated Phospholipase A2: A REDUCE-IT Biomarker Substudy” Learn more about the MBA for Executives program at Yale SOM. Email Howie and Harlan comments or questions. 

Howie and Harlan discuss a concerning new COVID-19 variant, the discovery casting doubt on a major fish-oil study, and the need for new models of funding research. Links: “New Omicron subvariant Centaurus could be the most immune-evasive yet, expert warns” “Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia” “Effects of Randomized Treatment With Icosapent Ethyl and a Mineral Oil Comparator on Interleukin-1β, Interleukin-6, C-Reactive Protein, Oxidized Low-Density Lipoprotein Cholesterol, Homocysteine, Lipoprotein(a), and Lipoprotein-Associated Phospholipase A2: A REDUCE-IT Biomarker Substudy” Learn more about the MBA for Executives program at Yale SOM. Email Howie and Harlan comments or questions. 

Having trouble lowering your cholesterol, blood sugar, C-Reactive Protein or reversing your fatty liver condition?  Did you know that the tocotrienols in vitamin E from various plants have been extensively researched for their effect on metabolic conditions? Dr. Barrie Tan has dedicated the last 35 years to exploring the benefits of tocotrienols from the annatto plant.  Dr. Tan is a scientist and researcher in addition to being the author of The Truth about Vitamin E: The Secret to Thriving with Annatto Tocotrienols.  In this episode of The Health Fix Podcast, Dr. Jannine Krause interviews Dr. Barrie Tan on how this powerful antioxidant can lower cholesterol, reduce inflammation, protect your liver, promote bone health, increase survival rates in cancer patients, and even kill cancer cells. What You'll Learn in This Episode: How vitamin C regenerates vitamin E The difference between tocotrienols and tocopherols How vitamin E protects all of your cells Why vitamin E can help with leaky gut and brain Resources From the Show: Dr. Barrie Tan & his free vitamin E book  Dr. Barrie Tan's research  

I don't know one person that doesn't struggle with the “life takes over” challenge. You have a goal, and it goes out the window very quickly because… life. Discovering why this is, what your reward mechanisms are, and how to finally achieve that goal using a keto diet. RESOURCES Today's guide: https://www.healthfulpursuit.com/learn/ Keto question? Need help? Send me a message: https://www.healthfulpursuit.com/contact/ Join Allison's program, use the code VOGEL50 for a discount: https://yourwellbeingtribe.com/start-here/  Ketogenic diet as a metabolic treatment for mental illness: https://pubmed.ncbi.nlm.nih.gov/32773571/ The Ketogenic Diet for the Treatment of Mood Disorders in Comorbidity With Epilepsy in Children and Adolescents: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7768824/ Depression and C-Reactive Protein in US Adults: https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/217001 PARTNERS Use the code KETODIET for 20% off Eaton Hemp: https://eatonhemp.com/ketodiet Paleovalley non-binge protein bars + whole food vitamin C + apple cider vinegar get 15% off your first order with code KETO: http://paleovalley.com/

On the the second episode of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 4/27/22 – 5/11/22. Hosts: Daniel Griffin and Sara Dong Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of Puscast! Links for this episode •Acute Hepatitis and Adenovirus Infection Among Children — Alabama, October 2021–February 2022(MMWR) •Case Series of False-Positive HIV Test Results in Pediatric Acute Lymphoblastic Leukemia Patients Following Chimeric Antigen Receptor T-Cell Therapy: Guidance on How to Avoid and Resolve Diagnostic Dilemmas (J IDSA) •Immunological correlates of prevention of the onset of seasonal H3N2 influenza (JID) •Use of a Modified Preexposure Prophylaxis Vaccination Schedule to Prevent Human Rabies: Recommendations of the Advisory Committee on Immunization Practices — United States, 2022 (MMWR) •Long-term Safety and Immunogenicity of a Tetravalent Dengue Vaccine Candidate in Children and Adults(MMWR) •The Role of C-Reactive Protein as a Triage Tool for Pulmonary Tuberculosis in Children (J PIDS) •Factors Potentially Contributing to the Contamination of Packaged Leafy Greens Implicated in the Outbreak of Salmonella Typhimurium During the Summer of 2021 (FDA) •Short-course intravenous antibiotics for young infants with urinary tract infection (Arch Dis Children) •Real-World Comparison of Bezlotoxumab to Standard of Care Therapy for Prevention of Recurrent Clostridioides difficile Infection in Patients at High Risk for Recurrence (Clin Inf Dis) •2021 Focused Update Guidelines on Management of Clostridioides difficile Infection in Adults (Clin Inf Dis) •Treatment outcomes 24 months after initiating short, all-oral bedaquiline-containing or injectable-containing rifampicin-resistant tuberculosis treatment regimens in South Africa (Lancet) •Use of Novel Strategies to Develop Guidelines for Management of Pyogenic Osteomyelitis in Adults (JAMA) •Persistent MRSA Bacteremia: Resetting the Clock for Optimal Management (Clin Inf Dis) •Frequency and Duration of, and Risk Factors for, Diagnostic Delays Associated with Histoplasmosis (J Fungi) •Intestinal parasitic infections and associated factors among people living with HIV attending Dessie Referral Hospital, Dessie town, North-east Ethiopia (AIDS Res Ther) •Association of zoonotic protozoan parasites with microplastics in seawater and implications for human and wildlife health (Nat Sci Rep) •Climate change increases cross-species viral transmission risk (Nature and TWiV 898) Intro music is by Ronald Jenkees Send your questions for Puscast to puscast@microbe.tv

Huberman Lab Podcast Notes Key Takeaways Six pillars of hormone health: (1) diet (specifically caloric restriction); (2) exercise (specifically resistance training); (3) stress & stress optimization; (4) sleep optimization; (5) sunlight; (6) spirit – dial in the body, mind, and soul connectionThink of yourself as a Venn diagram: you have a body, mind, and soul – you can't completely be well if you're missing the health of one areaTip to get your doctor to order more bloodwork than the basic panel: tell your doctor your (fill in the blank) – energy, sleep, endurance, etc. – is not as good as it used to beHigh alcohol intake and smoking marijuana will ultimately decrease testosteroneCaffeine has a negligible effect on hormonesVegans: you are possibly at risk of not getting enough of certain types of fats and nutrients to maintain a proper ratio of testosterone to estrogen – supplement with algae or other healthy fatsTo naturally increase growth hormone output: don't eat within 2 hours of sleep, get good deep sleep, resistance exercise early in the day, manage stress        A word of caution about peptides: work with a physician! There are so many bad quality peptides with detrimental side effects       Read the full notes @ podcastnotes.orgMy guest is Dr. Kyle Gillett, MD, a dual board-certified physician in family medicine and obesity medicine and an expert in optimizing hormone levels to improve overall health and well-being in both men and women. We discuss how to improve hormones using behavioral, nutritional, and exercise-based tools and safely and rationally approach supplementation and hormone therapies. We discuss testosterone and estrogen and how those hormones relate to fertility, mood, aging, relationships, disease pathologies, thyroid hormone, growth hormone, prolactin, dopamine and peptides that impact physical and mental health and vitality across the lifespan. The episode is rich with scientific mechanisms and tools for people to consider. Thank you to our sponsors Thesis: https://takethesis.com/huberman InsideTracker: https://insidetracker.com/huberman ROKA: https://roka.com - use code "huberman" See Andrew Huberman Live: The Brain Body Contract Tuesday, May 17th: Seattle, WA Wednesday, May 18th: Portland, OR https://hubermanlab.com/tour Our Patreon page https://www.patreon.com/andrewhuberman Supplements from Thorne https://www.thorne.com/u/huberman For the full show notes, visit hubermanlab.com. Timestamps (00:00:00) Dr. Kyle Gillett, MD, Hormone Optimization    (00:03:10) The Brain-Body Contract  (00:04:10) Thesis, InsideTracker, ROKA (00:08:24) Preventative Medicine & Hormone Health  (00:14:17) The Six Pillars of Hormone Health Optimization (00:17:14) Diet for Hormone Health, Blood Testing (00:20:21) Exercise for Hormone Health  (00:21:06) Caloric Restriction, Obesity & Testosterone  (00:23:55) Intermittent Fasting, Growth Hormone (GH), IGF-1 (00:29:08) Sleep Quality & Hormones (00:35:03) Testosterone in Women (00:38:55) Dihydrotestosterone (DHT), Hair Loss  (00:43:46) DHT in Men and Women, Turmeric/Curcumin, Creatine (00:50:10) 5-Alpha Reductase, Finasteride, Saw Palmetto  (00:52:30) Hair loss, DHT, Creatine Monohydrate (00:55:07) Hair Regrowth, Male Pattern Baldness (00:58:12) Polycystic Ovary Syndrome (PCOS), Inositol, DIM (01:04:00) Oral Contraception, Perceived Attractiveness, Fertility  (01:10:31) Testosterone & Marijuana or Alcohol (01:14:27) Sleep Supplement Frequency (01:15:34) Testosterone Supplementation & Prostate Cancer  (01:20:24) Prostate Health, Dietary Fiber, Saw Palmetto, C-Reactive Protein   (01:24:05) Prostate Health & Pelvic Floor, Viagra, Tadalafil  (01:30:54) Testosterone Replacement Therapy (TRT) (01:35:17) Estrogen & Aromatase Inhibitors, Calcium D-Glucarate, DIM  (01:39:28) Lifestyle Factors to Increase Testosterone/Estrogen Levels, Dietary Fats  (01:45:34) Aromatase Supplements: Ecdysterone, Turkesterone (01:47:04) Tongkat Ali (Long Jack), Estrogen/Testosterone levels  (01:52:25) Fadogia Agrestis, Luteinizing Hormone (LH), Frequency (01:56:44) Boron, Sex Hormone Binding Globulin (SHBG) (01:58:13) Human Chorionic Gonadotropin (hCG), Fertility (02:04:18) Prolactin & Dopamine, Pituitary Damage  (02:08:34) Augmenting Dopamine Levels: Casein, Gluten, Vitamin E, Vitamin B6 (P5P) (02:12:30) L-Carnitine & Fertility, TMAO & Allicin (Garlic)  (02:18:19) Blood Test Frequency  (02:19:41) Long-Term Relationships & Effects on Hormones (02:25:33) Nesting Instincts: Prolactin, Childbirth & Relationships (02:29:05) Cold & Hot Exposure, Hormones & Fertility (02:32:34) Peptide Hormones: Insulin, Tesamorelin, Ghrelin  (02:37:24) Growth Hormone-Releasing Peptides (GHRPs) (02:39:38) BPC-157 & Injury, Dosing Frequency (02:45:23) Uses for Melanotan  (02:48:21) Spiritual Health Impact on Mental & Physical Health  (02:54:18) Caffeine & Hormones  (02:56:19) Neural Network Newsletter, Zero-Cost Support, YouTube Feedback, Spotify Review, Apple Reviews, Sponsors, Patreon, Thorne, Instagram, Twitter, Brain-Body Contract Title Card Photo Credit: Mike Blabac Disclaimer

My guest is Dr. Kyle Gillett, MD, a dual board-certified physician in family medicine and obesity medicine and an expert in optimizing hormone levels to improve overall health and well-being in both men and women. We discuss how to improve hormones using behavioral, nutritional, and exercise-based tools and safely and rationally approach supplementation and hormone therapies. We discuss testosterone and estrogen and how those hormones relate to fertility, mood, aging, relationships, disease pathologies, thyroid hormone, growth hormone, prolactin, dopamine and peptides that impact physical and mental health and vitality across the lifespan. The episode is rich with scientific mechanisms and tools for people to consider. Thank you to our sponsors Thesis: https://takethesis.com/huberman InsideTracker: https://insidetracker.com/huberman ROKA: https://roka.com - use code "huberman" See Andrew Huberman Live: The Brain Body Contract Tuesday, May 17th: Seattle, WA Wednesday, May 18th: Portland, OR https://hubermanlab.com/tour Our Patreon page https://www.patreon.com/andrewhuberman Supplements from Thorne https://www.thorne.com/u/huberman For the full show notes, visit hubermanlab.com. Timestamps (00:00:00) Dr. Kyle Gillett, MD, Hormone Optimization    (00:03:10) The Brain-Body Contract  (00:04:10) Thesis, InsideTracker, ROKA (00:08:24) Preventative Medicine & Hormone Health  (00:14:17) The Six Pillars of Hormone Health Optimization (00:17:14) Diet for Hormone Health, Blood Testing (00:20:21) Exercise for Hormone Health  (00:21:06) Caloric Restriction, Obesity & Testosterone  (00:23:55) Intermittent Fasting, Growth Hormone (GH), IGF-1 (00:29:08) Sleep Quality & Hormones (00:35:03) Testosterone in Women (00:38:55) Dihydrotestosterone (DHT), Hair Loss  (00:43:46) DHT in Men and Women, Turmeric/Curcumin, Creatine (00:50:10) 5-Alpha Reductase, Finasteride, Saw Palmetto  (00:52:30) Hair loss, DHT, Creatine Monohydrate (00:55:07) Hair Regrowth, Male Pattern Baldness (00:58:12) Polycystic Ovary Syndrome (PCOS), Inositol, DIM (01:04:00) Oral Contraception, Perceived Attractiveness, Fertility  (01:10:31) Testosterone & Marijuana or Alcohol (01:14:27) Sleep Supplement Frequency (01:15:34) Testosterone Supplementation & Prostate Cancer  (01:20:24) Prostate Health, Dietary Fiber, Saw Palmetto, C-Reactive Protein   (01:24:05) Prostate Health & Pelvic Floor, Viagra, Tadalafil  (01:30:54) Testosterone Replacement Therapy (TRT) (01:35:17) Estrogen & Aromatase Inhibitors, Calcium D-Glucarate, DIM  (01:39:28) Lifestyle Factors to Increase Testosterone/Estrogen Levels, Dietary Fats  (01:45:34) Aromatase Supplements: Ecdysterone, Turkesterone (01:47:04) Tongkat Ali (Long Jack), Estrogen/Testosterone levels  (01:52:25) Fadogia Agrestis, Luteinizing Hormone (LH), Frequency (01:56:44) Boron, Sex Hormone Binding Globulin (SHBG) (01:58:13) Human Chorionic Gonadotropin (hCG), Fertility (02:04:18) Prolactin & Dopamine, Pituitary Damage  (02:08:34) Augmenting Dopamine Levels: Casein, Gluten, Vitamin E, Vitamin B6 (P5P) (02:12:30) L-Carnitine & Fertility, TMAO & Allicin (Garlic)  (02:18:19) Blood Test Frequency  (02:19:41) Long-Term Relationships & Effects on Hormones (02:25:33) Nesting Instincts: Prolactin, Childbirth & Relationships (02:29:05) Cold & Hot Exposure, Hormones & Fertility (02:32:34) Peptide Hormones: Insulin, Tesamorelin, Ghrelin  (02:37:24) Growth Hormone-Releasing Peptides (GHRPs) (02:39:38) BPC-157 & Injury, Dosing Frequency (02:45:23) Uses for Melanotan  (02:48:21) Spiritual Health Impact on Mental & Physical Health  (02:54:18) Caffeine & Hormones  (02:56:19) Neural Network Newsletter, Zero-Cost Support, YouTube Feedback, Spotify Review, Apple Reviews, Sponsors, Patreon, Thorne, Instagram, Twitter, Brain-Body Contract Title Card Photo Credit: Mike Blabac Disclaimer

C-reactive protein is a well-known marker of inflammation and may be preoperatively elevated in the absence of infection in adult cardiac surgery patients, indicating a baseline inflammatory process. We conducted a literature search to assess the available evidence on whether there is an association between preoperative C-reactive protein and acute kidney injury after coronary artery bypass grafting. Included only were observational studies which investigated this association.

In this episode, Dr. Scott and Tommy discuss Psoriatic Arthritis and a host of related inflammatory and auto-immune conditions. These ailments are being increasingly acknowledged to have metabolic commonalities, and studies show improvements through fasting and other insulin-lowering methods.  Rheum Doctor - What is a high CRP? Measuring inflammation The Impact of Intermittent Fasting (Ramadan Fasting) on Psoriatic Arthritis Disease Activity, Enthesitis, and Dactylitis: A Multicentre Study Psoriatic Arthritis and Diabetes Mellitus: A Narrative Review Effect of fasting with two meals on BMI and inflammatory markers of metabolic syndrome Relationship between C-reactive protein and visceral adipose tissue in healthy Japanese subjects   Show Transcript: www.thefastingforlife.com/blog   If you enjoy the podcast, would you please tap on the stars below and consider leaving a short review on Apple Podcasts/iTunes? It takes less than 60 seconds, and it makes a difference in helping bring you the best original content each week. We also really enjoy reading them!   Sign up for the Fasting For Life newsletter at www.thefastingforlife.com   Join the Community on Facebook!   Follow Fasting For Life: www.facebook.com/thefastingforlife www.instagram.com/thefastingforlife

In this episode, I am joined by Dr. David Sinclair, tenured Professor of Genetics at Harvard Medical School and an expert researcher in the field of longevity. Dr. Sinclair is also the author of the book Lifespan: Why We Age & Why We Don't Have To, and the host of the Lifespan Podcast, which launches January 5, 2022.  In this interview, we discuss the cellular and molecular mechanisms of aging and what we all can do to slow or reverse the aging process. We discuss fasting and supplementation with resveratrol, NAD, metformin, and NMN. We also discuss the use of caffeine, exercise, cold exposure, and why excessive iron load is bad for us. We discuss food choices for offsetting aging and promoting autophagy (clearance of dead cells). And we discuss the key blood markers everyone should monitor to determine your biological versus chronological age. We also discuss the future of longevity research and technology. This episode includes lots of basic science and specific, actionable protocols, right down to the details of what to do and when. By the end, you will have in-depth knowledge of the biology of aging and how to offset it.   Thank you to our sponsors: ROKA - https://www.roka.com - code "huberman" InsideTracker - https://www.insidetracker.com/huberman Magic Spoon - https://www.magicspoon.com/huberman   Dr. David Sinclair Links: Lifespan Podcast: https://lifespanpodcast.com  Twitter: https://twitter.com/davidasinclair Instagram: https://www.instagram.com/davidsinclairphd/   YouTube: https://www.youtube.com/davidsinclairpodcast   Lifespan (book): https://amzn.to/3mAZQjF  Aging Test Waitlist: https://www.doctorsinclair.com   Harvard Lab Website: https://sinclair.hms.harvard.edu    Our Patreon page: https://www.patreon.com/andrewhuberman    Supplements from Thorne: http://www.thorne.com/u/huberman    Social: Instagram - https://www.instagram.com/hubermanlab  Twitter - https://twitter.com/hubermanlab  Facebook - https://www.facebook.com/hubermanlab  Website - https://hubermanlab.com  Newsletter - https://hubermanlab.com/neural-network    Timestamps: 00:00:00 Dr. David Sinclair, Harvard Medical School 00:03:30 ROKA, InsideTracker, Magic Spoon 00:07:45 “Aging as a Disease” vs. Longevity & Anti-Aging 00:10:23 What Causes Aging? The Epigenome 00:15:53 Cosmetic Aging  00:17:15 Development Never Stops, Horvath Clock 00:20:12 Puberty Rate as a Determinant of Aging Rate 00:23:00 Fasting, Hunger & Food Choices 00:32:44 Fasting Schedules, Long Fasts, (Macro)Autophagy 00:34:50 Caffeine, Electrolytes  00:35:56 Blood Glucose & the Sirtuins; mTOR 00:37:55 Amino Acids: Leucine, “Pulsing” 00:44:35 Metformin, Berberine 00:50:29 Resveratrol, Wine 00:53:20 What Breaks a Fast? 00:56:45 Resveratrol, NAD, NMN, NR; Dosage, Timing 01:09:10 Are Artificial Sweeteners Bad for Us? 01:12:04 Iron Load & Aging 01:15:05 Blood Work Analysis 01:19:37 C-Reactive Protein, Cholesterol: Serum & Dietary 01:26:02 Amino Acids, Plants, Antioxidants 01:33:45 Behaviors That Extend Lifespan, Testosterone, Estrogen 01:40:35 Neuroplasticity & Neural Repair 01:46:19 Ice Baths, Cold Showers, “Metabolic Winter” 01:48:07 Obesity & How It Accelerates Aging, GnRH  01:52:10 Methylation, Methylene Blue, Cigarettes  01:56:17 X-Rays   01:59:00 Public Science Education, Personal Health 02:05:40 The Sinclair Test You Can Take: www.doctorsinclair.com 02:08:13 Zero-Cost Support & Resources, Sponsors, Patreon, Supplements, Instagram    Please note that The Huberman Lab Podcast is distinct from Dr. Huberman's teaching and research roles at Stanford University School of Medicine. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Huberman Lab Podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.   Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com 

Aging-US published a Special Collection on Eye Disease which included "Activation of C-reactive protein proinflammatory phenotype in the blood retinal barrier in vitro: implications for age-related macular degeneration" which reported that the retinal pigment epithelium (RPE) is considered one of the main targets of age-related macular degeneration (AMD), the leading cause of irreversible vision loss among the ageing population worldwide. Increased levels of circulating pentameric C-reactive protein (pCRP) are associated with higher risk of AMD. Monomeric form of pCRP has been detected in drusen, the hallmark deposits associated with AMD, and we have found that mCRP induces oBRB disruption Dr. Blanca Molins from The IDIBAPS, Hospital Clínic de Barcelona said, "Age-related macular degeneration (AMD) is the primary cause of irreversible vision loss among the ageing population worldwide." AMD presents RPE cell abnormalities, disruption of the outer blood-retinal-barrier (oBRB), and degeneration of photoreceptors. Altered immune responses are thought to contribute to the dry AMD phenotype. Loss of parainflammation control contributes to AMD by invoking a chronic, heightened immune response that causes tissue destruction. mCRP has been identified in ocular drusen and other subepithelial deposits, as well as in the choroid, and contributes to oBRB disruption in vitro. The "non-risk" Factor H (FH) variant can effectively bind to mCRP to dampen its proinflammatory activity. MCRP levels are elevated in individuals with the high-risk CFH genotype [29, 30] - this is because there is no CRP transcription in retinal tissue. The Molins Research Team concluded in their https://www.aging-us.com/article/103655/">Aging-US Research Output, "our findings further support mCRP direct contribution to progression of AMD, at least at the RPE level. The topological experiments elicit that mCRP is proinflammatory when present on the apical side of the RPE. However, mCRP is likely to only reach the apical side of the RPE in compromised RPE health and where barrier functions are compromised. Thus, a plausible scenario would infer that, in the presence of an already aged/damaged RPE, mCRP reaches the apical side of the RPE to amplify the proinflammatory microenvironment and enhance barrier disruption. With respect to previous findings, this pathologic mechanism will be more prevalent in patients carrying the FH risk polymorphism for AMD, where mCRP proinflammatory effects remain unrestrained." Full Text - https://www.aging-us.com/article/103655/text Correspondence to: Blanca Molins email: bmolins@clinic.cat Keywords: age-related macular degeneration, retinal pigment epithelium, inflammation, C-reactive protein About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research as well as topics beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, cancer, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR among others), and approaches to modulating these signaling pathways. To learn more about Aging-US, please visit http://www.Aging-US.com or connect with @AgingJrnl Aging-US is published by Impact Journals, LLC please visit http://www.ImpactJournals.com or connect with @ImpactJrnls Media Contact 18009220957x105 MEDIA@IMPACTJOURNALS.COM

Aging-US published a Special Collection on Eye Disease which included "Activation of C-reactive protein proinflammatory phenotype in the blood retinal barrier in vitro: implications for age-related macular degeneration" which reported that the retinal pigment epithelium (RPE) is considered one of the main targets of age-related macular degeneration (AMD), the leading cause of irreversible vision loss among the ageing population worldwide. Increased levels of circulating pentameric C-reactive protein (pCRP) are associated with higher risk of AMD. Monomeric form of pCRP has been detected in drusen, the hallmark deposits associated with AMD, and we have found that mCRP induces oBRB disruption Dr. Blanca Molins from The IDIBAPS, Hospital Clínic de Barcelona said, "Age-related macular degeneration (AMD) is the primary cause of irreversible vision loss among the ageing population worldwide." AMD presents RPE cell abnormalities, disruption of the outer blood-retinal-barrier (oBRB), and degeneration of photoreceptors. Altered immune responses are thought to contribute to the dry AMD phenotype. Loss of parainflammation control contributes to AMD by invoking a chronic, heightened immune response that causes tissue destruction. mCRP has been identified in ocular drusen and other subepithelial deposits, as well as in the choroid, and contributes to oBRB disruption in vitro. The "non-risk" Factor H (FH) variant can effectively bind to mCRP to dampen its proinflammatory activity. MCRP levels are elevated in individuals with the high-risk CFH genotype [29, 30] - this is because there is no CRP transcription in retinal tissue. The Molins Research Team concluded in their https://www.aging-us.com/article/103655/ Aging-US Research Output, "our findings further support mCRP direct contribution to progression of AMD, at least at the RPE level. The topological experiments elicit that mCRP is proinflammatory when present on the apical side of the RPE. However, mCRP is likely to only reach the apical side of the RPE in compromised RPE health and where barrier functions are compromised. Thus, a plausible scenario would infer that, in the presence of an already aged/damaged RPE, mCRP reaches the apical side of the RPE to amplify the proinflammatory microenvironment and enhance barrier disruption. With respect to previous findings, this pathologic mechanism will be more prevalent in patients carrying the FH risk polymorphism for AMD, where mCRP proinflammatory effects remain unrestrained." Full Text - https://www.aging-us.com/article/103655/text Correspondence to: Blanca Molins email: bmolins@clinic.cat Keywords: age-related macular degeneration, retinal pigment epithelium, inflammation, C-reactive protein About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research as well as topics beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, cancer, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR among others), and approaches to modulating these signaling pathways. To learn more about Aging-US, please visit http://www.Aging-US.com or connect with @AgingJrnl Aging-US is published by Impact Journals, LLC please visit http://www.ImpactJournals.com or connect with @ImpactJrnls Media Contact 18009220957x105 MEDIA@IMPACTJOURNALS.COM

Scientists find lean subjects made protective antibodies after infection while obese subjects did not make protective antibodies—they made maladaptive autoantibodies instead. Researchers speculate that leptin plays a role in skewing the immune response toward autoimmunity after infection. Here's the details! Related: Save your seat in the upcoming Blood Work MasterClass Live Training RSVP Here: https://courses.highintensityhealth.com/store/hgwDdo2p Research, Images and Articles: https://bit.ly/3qsGYX6 Time Stamps: 0:00 Intro 0:09 Endemic Virus 0:59 Obese Don't Make Protective Antibodies 1:15 Obese people make autoantibodies 1:40 Leptin and Fat on Fire 2:40 Leptin exacerbates inflammation, autoimmunity 3:13 Study we're discussing 3:49 Make Americans Healthy Again 4:35 Blood Work MasterClass 5:30 Daniela Frasca, PhD: Obesity Hinders Immune System Response 6:10 Antibodies and BMI, C-Reactive Protein 6:43 Metainflammation and Inflammaging 7:15 Blood sugar and inflammation 8:13 Leptin and immunity 9:29 Summary of Study: immune tolerance breakdown 11:30 Lifestyle matters 12:30 Antibodies directed at fat tissue 12:52 Omega-6 Oils, Seed Oils & autoimmunity 13:50 Excess deaths related to heart disease on the rise 14:42 Image: CRP and autoantibodies 15:39 New study summary 16:21 Italy Research from fat cell spill over 16:58 Obesity is an autoimmune disease 17:05 Change your habits 17:47 Image: Behavior model Books and References: Tiny Habits: The Small Changes That Change Everything: https://amzn.to/3CbpvEQ Frasca, D., Reidy, L., Cray, C., Diaz, A., Romero, M., Kahl, K., & Blomberg, B. B. (2021). Influence of obesity on serum levels of SARS-CoV-2-specific antibodies in COVID-19 patients. Plos One, 16(3), e0245424–16.   Frasca, D., Reidy, L., Romero, M., Diaz, A., Cray, C., Kahl, K., & Blomberg, B. B. (2021). The majority of SARS-CoV-2-specific antibodies in COVID-19 patients with obesity are autoimmune and not neutralizing. International Journal of Obesity, 1–6.

Commentary by Dr. Valentin Fuster

Episode NotesFor more information, contact us at 859-721-1414 or myhealth@prevmedheartrisk.com. Also, check out the following resources:  ·PrevMed's website·PrevMed's YouTube channel·PrevMed's Facebook page

Sleeping is one of those things that we don’t think too much about until we start experiencing issues with it. This podcast is about some of those issues and a few suggested solutions. As we get older sleep patterns change and if we don’t sleep well or long enough it can affect our bodies and our brains. One of the things your body and brain do when you’re sleeping is to clean up all of the residue from the day. During sleep your body also reduces inflammation and C-Reactive Protein, lowers blood sugar levels, and kills harmful bacteria and viruses. Not getting enough sleep can lead to weight gain, heart disease, and depression among other negative ramifications. The large majority of people need 7-8 hours of sleep a night but as I know from personal experience many of us only get 5.5-6.5 hours. I used to get the lower amount but now I get 7-8. Other things covered in this podcast is your sleeping environment, snoring, supplements, blue-blocking glasses, and other things that can help you to sleep better.  

DBOL ONLY CYCLE, INCRELEX IGF, TEST DOSE ON A CUT & MORE

This episode is also available as a blog post: http://webrl.org/2021/05/03/c-reactive-protein-crp-what-it-is-and-why-it-may-be-high/

With Mark Pepys and Floriaan Schmidt, University of College London - UK Link to paper Link to editorial

You live in a zoo… Don’t believe me? Look around you… Synthetic food, separation from nature-> chronic disease rates skyrocketing, rates of obesity, depression and general unhappiness rising rapidly… The same things happen to wild animals when they are placed into zoos!  In this week’s podcast (Fundamental Health, available on Apple Podcasts, YouTube) @dranthonygustin and I dive back into our Africa adventures with some of the last hunter-gatherers left on the planet, the Hadza. This is part 2 of this series, check out part 1 from two weeks ago… In this episode we also answer your questions about the Hadza and fill in all the gaps from our first episode about our adventures with them. #theremembering Time stamps: 0:10:49 Podcast Begins 0:12:39 Urban living in healthy Tanzanians is associated with an inflammatory status driven by dietary and metabolic changes https://www.nature.com/articles/s41590-021-00867-8#:~:text=In%20a%20cohort%20of%20323,metabolites%20accounting%20for%20these%20differences. 0:13:56 Misinformation in modern papers on the Hadza | Cancel culture in the scientific community 0:26:49 Eat what is easily edible in nature 0:29:46 And now a word from Big Honey 0:31:07 Natural Honey Lowers Plasma Glucose, C-Reactive Protein, Homocysteine, and Blood Lipids in Healthy, Diabetic, and Hyperlipidemic Subjects: Comparison with Dextrose and Sucrose https://www.liebertpub.com/doi/abs/10.1089/109662004322984789 0:40:25 To be wild is to be healthy | How to rewild 0:47:32 What do the Hadza do to be happy? 0:49:43 Happiness is humanity's default 0:53:53 How did the Hadza sleep? 0:58:03 Surfing in Costa Rica 1:01:24 The remarkable patience of the Hadza 1:00:53 Do the Hadza operate in hierarchy? 1:13:13 An interesting theory on eating local, seasonal food 1:18:05 Prey Size Decline as a Unifying Ecological Selecting Agent in Pleistocene Human Evolution https://www.mdpi.com/2571-550X/4/1/7/htm 1:19:19 The evolution of the human trophic level during the Pleistocene https://onlinelibrary.wiley.com/doi/10.1002/ajpa.24247 1:19:44 Too smart for our own good | Refining away our last source of real food 1:23:54 The hygiene of the Hadza 1:26:35 How to find your true love 1:30:47 Marriage and sexuality 1:37:49 Gender roles of the Hadza 1:39:47 Some thoughts on human customs 1:43:31 Education of the hadza 1:50:52 More on the eating habits of the Hadza 1:53:17 The Hadza's medicine 1:54:49 Oral health 1:57:49 What kind of movement do the Hadza engage in? 2:03:17 What was the scariest part of the trip? 2:04:58 The Nicoya region of Costa Rica: a high longevity island for elderly males https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241350/ 2:04:59 The truth about the blue zones 2:13:13 Hunter-gatherers live as long as we do   Sponsors: Heart & Soil: www.heartandsoil.co White Oak Pastures: www.whiteoakpastures.com Use CarnivoreMD for 10% off your first order Belcampo: www.belcampo.com, use CarnivoreMD for 20% off your order Helix Mattress: www.Helixsleep.com.carnivoremd for $200 off BluBlox: www.blublox.com. CarnivoreMD for 15%

This is the third AMA podcast I’ve done and it was a fun one!  Time stamps with questions I answer in this one are below. If you have questions for future AMAs send them to radicalhealth@heartandsoil.co!    Time Stamps:  0:11:08 Ask Me Anything! 0:13:21 What are the best labs to get done? 0:21:49 How do we most effectively share the animal-based lifestyle with friends and family? 0:24:34 Is a plant-based diet more financially sustainable than an animal-based diet? 0:27:03 Zach Bush, Tetrahydrate, and eating dirt 0:32:49 The Scoop on Candida 0:39:15 Natural Honey Lowers Plasma Glucose, C-Reactive Protein, Homocysteine, and Blood Lipids in Healthy, Diabetic, and Hyperlipidemic Subjects: Comparison with Dextrose and Sucrose https://www.liebertpub.com/doi/10.1089/109662004322984789?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed& 0:39:15 Why honey is different than other carbs 0:42:35 Paleoanthropology and the origins of modern disease Https://www.youtube.com/watch?v=3fewDdSUSwg 0:42:35 Why were the ancient Egyptians so unhealthy? 0:46:30 Nutrition and health in agriculturalists and hunter-gatherers https://www.proteinpower.com/nutrition-and-health-in-agriculturalists-and-hunter-gatherers/ 0:48:55 Earliest evidence for caries and exploitation of starchy plant foods in Pleistocene hunter-gatherers from Morocco https://www.pnas.org/content/111/3/954 0:58:53 Are peptide supplements legit? 1:03:23 Diet of ancient Egyptians inferred from stable isotope systematics https://www.sciencedirect.com/science/article/abs/pii/S0305440314000843 1:03:42 Reconstructing Ancient Egyptian Diet through Bone Elemental Analysis Using LIBS (Qubbet el Hawa Cemetery) https://www.hindawi.com/journals/bmri/2015/281056/ 1:04:38 Evidence for dietary change but not landscape use in South African early hominins https://pubmed.ncbi.nlm.nih.gov/22878716/ 1:05:10 Stable isotopes reveal patterns of diet and mobility in the last Neandertals and first modern humans in Europe https://www.nature.com/articles/s41598-019-41033-3 1:05:50 The lowdown on sulforaphane 1:07:20 Concentrations of thiocyanate and goitrin in human plasma, their precursor concentrations in brassica vegetables, and associated potential risk for hypothyroidism https://pubmed.ncbi.nlm.nih.gov/26946249/ 1:08:22 Sulforaphane Induces Oxidative Stress and Death by p53-Independent Mechanism: Implication of Impaired Glutathione Recycling https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965485/ 1:14:10 Antioxidants in food: mere myth or magic medicine? https://pubmed.ncbi.nlm.nih.gov/22059961/ 1:15:50 Is linoleic acid really proven to be unhealthy? 1:15:59 Minnesota coronary experiment Https://www.bmj.com/content/bmj/353/bmj.i1246.full.pdf 1:16:04 Sydney Diet Heart Study https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.27.1_supplement.127.4 1:16:25 A high linoleic acid diet increases oxidative stress in vivo and affects nitric oxide metabolism in humans https://pubmed.ncbi.nlm.nih.gov/9844997/   -- Heart & Soil: Heartandsoil.co for grass-fed desiccated organ supplements White Oak: Use “CarnivoreMD” at whiteoakpastures.com Belcampo: Use “CarnivoreMD” or “Carnivore10” at www.belcampo.com Let’s Get Checked: www.trylgc.com/carnivoremd Cinder: cindergrill.com/pages/carnivoremd

Can C-reactive protein levels predict respiratory decline in patients with COVID-19? Find out about this and more in today’s PV Roundup podcast.

How amazing are olives? What is the olive meaning in the Bible? How often should you eat olives? Learn the olive tree meaning and how eating olives is a simple way to improve your health!   We’ll talk about the health benefits of olives, olive meaning in the Bible, and more!   Treasures of Healthy Living from the Bible DVD Series: https://designedhealthyliving.com/dvds   Here are 7 powerful reasons to eat olives. These include spiritual and physical health benefits of olives - both the olive fruit and olive oil, so you’ll learn why eating olives everyday is a great thing. (The first two are spiritual benefits of olives!)   Eating olives helps us remember the message of salvation.    The olive tree is an eternal tree, and spiritually, the eternal message that Jesus came to give us is the message of salvation.  This message of salvation is taught to us in John 3:16, “For God so loved the world that he gave his only begotten Son, that whosoever believes in Him shall not perish, but have everlasting life.”    Jesus brought us the message of salvation and one of the biblical characteristics of the olive tree is it is eternal. It is a perfect olive tree symbolism because it can last for hundreds of years.    The olive fruit helps us to recognize God at work in our lives.   The olives had to go through a pressing. So the first pressing was the oil that was used for the tabernacle. It was used for lighting in the tabernacle. And that's going to be the purest oil we always offer God the first of our fruits, the purest that we have. The second oil pressed would've been used for fires. And then the third oil press would have been used for lighting in our homes.    So we always want to give God our first fruits. We always think of the first pressing of olives in 2 Corinthians, where it says, “We are pressed but not crushed. We are perplexed, but not in despair. We are persecuted but not forsaken. Cast down, but not destroyed.” The olive tree stands for eternity and remember, olives are really not pleasing at first. In fact, they are very bitter. It takes soaking and pressing to get the finest oil that makes the best flavor.    And so just as olives are oppressed and crushed, we too can have times that are that seem pressing. But through that brings out the best in us. The olive tree stands for eternity and Jesus is the one who offers eternal life.    Olives contain antihistamine properties.   So many people today take antihistamines for allergies but did you know that this antihistamine effect can be achieved through pure olives and pure olive oil? It is a good solution to those looking to take a natural antihistamine.   It lowers the risk of inflammation.   Inflammation  tell us we've got a problem and that's okay, but when we have a consistent inflammation, then we have trouble in our body. And so what it does is it just has an antiinflammatory effect and that is going to help us to feel better.    It lowers the level of C-Reactive Protein. So, C-Reactive protein is a blood measurement. Every time you're getting your blood work done, you should always get a CRP value done and you should track that result and always keep track of those results. CRP is important because it's an inflammation marker and when you have that number go up, there can be a risk of cancer. We're getting a risk of heart disease and other inflammatory problems. https://www.youtube.com/watch?v=bMA4F... Olives inhibit the inflammation process.    There's a pathway in your body called the arachidonic acid pathway, and this is an inflammation process, so it actually inhibits the inflammation process. So not only does it help to alleviate inflammation, it helps to inhibit the process of inflammation.    Olives have anticancer properties.   When olives and olive oil are processed correctly, you are receiving an antioxidant component called glutathione. It is your master antioxidant that’s the gatekeeper and it tries to get rid of free radicals.   I explain more about it in  my Treasures of Healthy Living DVD series, so you might want to check that out. I teach all about free radical damage and how to combat it effectively. You see, free radical damage is what makes us look older and what makes us feel older. https://www.youtube.com/watch?v=boNSB...   So if we can inhibit that with glutathione, the master antioxidant which we get from olives and olive oil, then we get the health benefits that give us the wow factor. And so these are five of the physical benefits, why you should add olives and olive oil in your diet. But it all comes down to this. Just as we are spiritual, we are physical and just as we are physical, we are spiritual. So Jesus uses stories of food to teach us physical aspects of who we are so that he can then teach us the spiritual elements of who we are. To learn more, visit https://thebiblicalnutritionist.com/

Dear Listeners, The C-Reactive Protein and the Erythrocyte Sedimentation Rate are both lab tests used to measure inflammation in the body. They are usually elevated during infectious, inflammatory, and malignant diseases.  The CRP is produced by the liver shortly after the offending process so it is a direct measure of inflammation. The ESR is based […] The post Podcast 69: C-Reactive Protein and Erythrocyte Sedimentation Rate appeared first on Primary Medicine Podcast.

Here are 7 powerful reasons to eat olives. These include spiritual and physical health benefits of olives - both the olive fruit and olive oil, so you’ll learn why eating olives everyday is a great thing. (The first two are spiritual benefits of olives!) 1. Eating olives helps us remember the message of salvation. The olive tree is an eternal tree, and spiritually, the eternal message that Jesus came to give us is the message of salvation. This message of salvation is taught to us in John 3:16, “For God so loved the world that he gave his only begotten Son, that whosoever believes in Him shall not perish, but have everlasting life.” Jesus brought us the message of salvation and one of the biblical characteristics of the olive tree is it is eternal. It is a perfect olive tree symbolism because it can last for hundreds of years. 2. The olive fruit helps us to recognize God at work in our lives. The olives had to go through a pressing. So the first pressing was the oil that was used for the tabernacle. It was used for lighting in the tabernacle. And that's going to be the purest oil we always offer God the first of our fruits, the purest that we have. The second oil pressed would've been used for fires. And then the third oil press would have been used for lighting in our homes. So we always want to give God our first fruits. We always think of the first pressing of olives in 2 Corinthians, where it says, “We are pressed but not crushed. We are perplexed, but not in despair. We are persecuted but not forsaken. Cast down, but not destroyed.” The olive tree stands for eternity and remember, olives are really not pleasing at first. In fact, they are very bitter. It takes soaking and pressing to get the finest oil that makes the best flavor. And so just as olives are oppressed and crushed, we too can have times that are that seem pressing. But through that brings out the best in us. The olive tree stands for eternity and Jesus is the one who offers eternal life. 3. Olives contain antihistamine properties. So many people today take antihistamines for allergies but did you know that this antihistamine effect can be achieved through pure olives and pure olive oil? It is a good solution to those looking to take a natural antihistamine. 4. It lowers the risk of inflammation. Inflammation tells us we've got a problem and that's okay, but when we have a consistent inflammation, then we have trouble in our body. And so what it does is it just has an anti-inflammatory effect and that is going to help us to feel better. 5. It lowers the level of C-Reactive Protein. So, C-Reactive protein is a blood measurement. Every time you're getting your blood work done, you should always get a CRP value done and you should track that result and always keep track of those results. CRP is important because it's an inflammation marker and when you have that number go up, there can be a risk of cancer. We're getting a risk of heart disease and other inflammatory problems. 6. Olives inhibit the inflammation process. There's a pathway in your body called the arachidonic acid pathway, and this is an inflammation process, so it actually inhibits the inflammation process. So not only does it help to alleviate inflammation, it helps to inhibit the process of inflammation. 7. Olives have anticancer properties. When olives and olive oil are processed correctly, you are receiving an antioxidant component called glutathione. It is your master antioxidant that’s the gatekeeper and it tries to get rid of free radicals. I explain more about it in my Treasures of Healthy Living DVD series, so you might want to check that out. I teach all about free radical damage and how to combat it effectively. You see, free radical damage is what makes us look older and what makes us feel older. So if we can inhibit that with glutathione, the master antioxidant which we get from olives and olive oil, then we get the health benefits that give us the wow factor. And so these are five of the physical benefits, why you should add olives and olive oil in your diet. But it all comes down to this. Just as we are spiritual, we are physical and just as we are physical, we are spiritual. So Jesus uses stories of food to teach us physical aspects of who we are so that he can then teach us the spiritual elements of who we are.

Dr. Ebell and Dr. Wilkes discuss the POEM titled ' C-reactive protein is the most useful biomarker for diagnosis of outpatient community-acquired pneumonia '

Episode 15: In this episode, Angie Gust goes over information from nutrition experts in relation to the coronavirus. One such expert, Dr. T. Colin Campbell posed the question, "Does a whole food, plant-based diet – known to prevent, and even reverse a broad range of chronic degenerative diseases – act in a similar way to minimize viral diseases?” Based on his studies with the hepatitis B virus, he says that a whole food plant based diet might offer an important path to fight the coronavirus pandemic. The important UN climate meeting, COP 26, that was supposed to convene this November, will take place between Nov 1 and 12, 2021.   References Akhtar, A.  Our Symphony With Animals ~ On Health, Empathy & Our Shared Destiny With Animals. Pegasus Books, NY, 2019. Borenstein, S. May 19, 2020. World carbon pollution falls 17% during pandemic peak. US News and World Report. https://www.usnews.com/news/business/articles/2020-05-19/study-world-carbon-pollution-falls-17-during-pandemic-peak Campbell, TC. Apr 27, 2020.The Path to Recovery through Nutrition: Our Most Important Defense Against COVID-19. https://plantpurecommunities.org/the-path-to-recovery/ Campbell, T. C., Chen, J., Liu, C., Li, J. & Parpia, B. Non-association of aflatoxin with primary liver cancer in a cross-sectional ecologic survey in the People’s Republic of China. Cancer Res. 50, 6882-6893 (1990). Campbell, T. C., and Howard Jacobson. Whole: Rethinking the Science of Nutrition. BenBella Books. 2014. Campbell, T. C. & Campbell, T. M. I. The China Study, startling implications for diet, weight loss and long-term health. pp. 184-187, 2006. Campbell, T. C., Chen, J., Liu, C., Li, J. & Parpia, B. Non-association of aflatoxin with primary liver cancer in a cross-sectional ecologic survey in the People’s Republic of China. Cancer Res. 50, 6882-6893 (1990). Campbell, T. C. Nutrition renaissance and public health policy. J. Nutr. Biology 3(1), 124-138 (2017). J Nutr Biol. 2017;3(1):124-138. doi:10.1080/01635581.2017.1339094 (2017). Campbell, T. C. The China Study: The Most Comprehensive Study of Nutrition Ever Conducted and the Startling Implications for Diet, Weight Loss and Long-Term Health. 2016. Print. CDC. 2020. COVID-19 Forecasts. https://www.cdc.gov/coronavirus/2019-ncov/covid-data/forecasting-us.html#anchor_1587397564229 Chen, J., Campbell, T. C., Li, B. & Peto, R. Diet, life-style and mortality in mainland China and Taiwan. A study of the characteristics of 85 Chinese counties. (Harvard University, 1998). Chen, J., Campbell, T. C., Li, B. & Peto, R. Diet, life-style and mortality in mainland China and Taiwan. A study of the characteristics of 85 Chinese counties. (Harvard University, 1998). Ferris, D. May 14, 2020. How lockdowns boost renewables and harm coal. , E&E News reporter Energywire. https://www.eenews.net/stories/1063130269 Hickman, M. 2009. Study claims meat creates half of all greenhouse gases. Independent. https://www.independent.co.uk/environment/climate-change/study-claims-meat-creates-half-of-all-greenhouse-gases-1812909.html Goodland, R and Anhang, J. 2009. Livestock and climate change: What is the key actors in climate change are...cows, pigs and chickens? World Watch. https://awellfedworld.org/wp-content/uploads/Livestock-Climate-Change-Anhang-Goodland.pdf Le Quéré, C., Jackson, R.B., Jones, M.W. et al. Temporary reduction in daily global CO2 emissions during the COVID-19 forced confinement. Nat. Clim. Chang. (2020). https://doi.org/10.1038/s41558-020-0797-x Pollan, M.  June, 2020. “The Sickness in Our Food Supply”. The New York Review of Books. https://www.nybooks.com/articles/2020/06/11/covid-19-sickness-food-supply/ Rowling, M.Vulnerable nations say delayed summit should not mean delayed climate actionThomson Reuters Foundation. https://news.trust.org/item/20200529132518-m7487/?utm_campaign=trending&utm_medium=trendingWebWidget&utm_source=detailPage&utm_content=link2 Shikha G. et al. Hospitalization rates and characteristics of patients hospitalized with laboratory-confirmed coronavirus disease 2019, COVID-NET, 14 States, March 1–30, 2020,” Morbidity and Mortality Weekly Report, Vol. 69, No. 15 (April 17, 2020).  Singhal, T. A Review of Coronavirus Disease-2019 (COVID-19). Indian J Pediatr. 2020 Apr;87(4):281-286. doi: 10.1007/s12098-020-03263-6. Epub 2020 Mar 13. Slisco, A. 5/7/2020. Elizabeth Warren and Cory Booker Join Forces on Bill to Ban Most Factory Farming by 2040. Newsweek. https://www.newsweek.com/elizabeth-warren-cory-booker-join-forces-bill-ban-most-factory-farming-2040-1502699 Woodend, D. May 15, 2020. Are we ready to “Meat the Future?”TheTyee.ca. https://thetyee.ca/Culture/2020/05/15/Ready-Meat-Future/ Xiaomin Luo et al. Prognostic Value of C-Reactive Protein in Patients with COVID-19,” medRxiv, March 23, 2020. The study has not yet been peer-reviewed.   

You’ve probably heard about taking care of your gut health for some time now. Let me help you understand why and how this could help out with weight loss too and your overall health.We’ll dive into some quick scientific concepts and also share with you how you can apply them to your daily food consumption. You’ll be surprised how some of your favorite food sources might actually be helping feed good gut bacteria.   [1:04] Having a lot of bad bugs hanging in your gut has been linked to many problems including diabetes, depression, cancer, heart disease, fibromyalgia, eczema, asthma, and obesity.   [1:48] Your gut sends messages to your brain and your brain sends messages to your gut.   [2:05] Researchers are finding that alterations in the gut microbes can actually influence the risk of brain disorders such as anxiety, depression, autism, and even dementia.   [5:01]  A study in 292 people found that those who were overweight had lower gut bacteria diversity and higher levels of C-Reactive Protein and inflammatory marker on the blood.   [10:23] Your gut bacteria can produce chemicals that can help you make you feel full. And by affecting your appetite, gut bacteria may play a role in your weight.   [11:25] A diet high in sugar can stimulate the growth in unhealthy bacteria in the gut which may contribute to weight gain and other chronic health disorders.   [11:55] Lack of sleep and chronic stress both contribute to gut imbalance.   [12:35] Fruits and vegetables contain many different fibers that are good for gut bacteria. Eating an assortment of plant-based food can improve gut bacteria diversity which is linked to a healthy weight.   [12:52] Nuts and seeds contain a lot of fiber and healthy fat which helps support the growth of healthy bacteria in the gut.   [13:28] The polyphenols in food like red wine, green tea, and dark chocolate can’t be digested alone but broken down by beneficial gut bacteria which promotes the growth of good bacteria.   [13:40] Probiotics may help restore healthy gut bacteria after an illness or a course of antibiotics and may even aid weight loss.   [14:45] Another study reported a milk drink containing a probiotic called lactobacillus for three weeks improved mood in people who had the lowest mood before the treatment.   [15:09] Prebiotics don’t break down on the small intestine, instead, they reach the colon where they feed your healthy gut bacteria.   [16:00] Beyond the numerous benefits like reducing inflammation which we know is key for weight loss, studies have found that Omega 3 Fatty Acids can support healthy gut flora. Links   Trudy Stone Website   Trudy Stone Facebook   Trudy Stone Pinterest   Trudy Stone Instagram   Trudy Stone Twitter  What type of dieter are you? Take the quiz! → trudyestone.com/quiz 

The Limping Embryo:Toxic Synovitis The sun rises over the San Joaquin Valley, California, this week the Coronavirus is all over the internet. The official name is COVID-19. As of February 27, 2020, over 80,000 people are estimated to be infected with coronavirus worldwide, with about 2,700 deaths2. It is spreading fast. There are 60 confirmed cases of COVID-19 in the United States1. No deaths have been reported so far. The coronavirus story is developing as I talk right now. In the meantime, there are about 40 million people infected by Influenza A&B (yes, 40 million), which have caused about 40,000 deaths around the world (40,000). Headlines about influenza A&B are less common these days.  ___________Welcome to Rio Bravo qWeek, the podcast of the Rio Bravo Family Medicine Residency Program, recorded weekly from Bakersfield, California, the land where growing is happening everywhere.The Rio Bravo Family Medicine Residency Program trains residents and students to prevent illnesses and bring health and hope to our community. Our mission: To Seek, Teach, and Serve. Sponsored by Clinica Sierra Vista, Providing compassionate and affordable care to patients throughout Kern and Fresno counties since 1971.__________Hello everyone, this is our first episode of Rio Bravo qWeek Podcast, which I called “The limping embryo”. An embryo is the elemental stage of an organism which evolves into a baby and then becomes an adult. This is the first episode (the embryo) of many more episodes that will come. BUT Why is this a “LIMPING” embryo? I invite you to listen until the end to find out.Let me introduce myself. My name is Hector Arreaza. As you can tell, I was not born in Minnesota or Oregon, and I’m reminded frequently about it when people ask me “Where are you from?”. The answer to that question is not easy, but I’ll try to keep it simple. I was born and raised in Venezuela (South America, or how some people may call it, “one of those Mexican countries”). I graduated from Medical school there, and when I was 24 years old, I served as a missionary in Salt Lake City, Utah. I went back to Venezuela for a few months and returned to the United States searching to further my education in a residency program. After spending some years as a Spanish translator, I found a residency spot in Bakersfield, California, where I completed a residency in Family medicine. I practiced primary care in a community health center for about 1 and a half years, and Dr Stewart, who is the program director of my residency program, offered me a position as faculty in the very same residency I graduated from. It has been over one year, and I am loving it.This podcast has been created to promote teaching and learning among residents, medical students, and faculty, and whoever listens to us wherever you are in the world. I hope you can enjoy it. “What we know is a drop… what we do not know is an ocean.” (Isaac Newton) “What we know is a drop”. That little drop of knowledge that we know is becoming larger and larger over time. Medicine has experienced many advances recently, and it is complicated to keep up with all the knowledge available to us. The idea of this podcast is to provide some traces of knowledge, maybe a mini-micro-drop to complement your study during your residency.During our podcast we will focus on 5 questions. A different guest will be invited to participate every week, and I will conduct the interview. The questions are:Question Number 1: Who are you? (the interviewee will have about 20 seconds to introduce him or herself)Question number 2: What did you learn today? (any topic is valid, the interviewee will explain what he or she learned, some additional questions may be asked to clarify the topic)Question number 3: Why is that knowledge important for you and your patients? (practical application)Question number 4: How did you get that knowledge? (learning habits)Question number 5: Where did that knowledge come from? (cite source)So, because this is the first episode, I want to follow the same pattern which I have established for the podcast. QUESTION NUMBER 1: Who are you? I already answered the first question about who I am. QUESTION NUMBER 2: What did you learn today?Today, I learned about toxic synovitis. Toxic synovitis is the most common cause of acute hip pain and limp in children ages 2-12. Irritable hip is a non-specific term referring to acute limping, hip pain, and stiffness which may be used in clinical practice instead of toxic synovitis.Toxic synovitis is a term that can be confusing for patients or even professionals who are unfamiliar with this condition, because it has nothing to do with a “toxic state or toxic appearance”. Other names are: Postinfectious arthritis, Transitory coxitis, Coxitis fugáx, Acute transient epiphysitis, but in general, a very appropriate name for this condition is transient synovitis. It is “transient”because it is a self-limited, inflammatory disorder of the hip (typically the hip, but it may affect other joints) affecting young children between ages 2-12, more commonly boys. Presentation: Typically presents with mild to moderate hip pain and limping with a history of recent upper respiratory infection (runny nose, cough, fever), which may not be always present, and it can be any kind of extraarticular viral infection, some examples: rubella, parvovirus B19, and coxsackie virus. The patient normally keeps his or her hip in abduction and external rotation, hip motion may be limited, but the patient will usually allow movement through a limited arc of motion. Normally the patient will be able to bear weight.Evaluation: History and Physical exam are very important. Physical exam findings include hip pain with movement, and no external signs of inflammation.Labs may include a Complete Blood Count, Erythrocyte Sedimentation Rate and C Reactive Protein, however, they are usually normal. Lab studies may be ordered to rule out other causes, especially septic arthritis.X-ray of hip is normal, however, you can have minor changes: early radiographic signs may include capsular distention, joint space widening, decreased definition of soft tissue planes around the hip joint, or slight demineralization of the bone of the proximal femur. The primary role of plain radiographs is ruling out other disorders.Ultrasound may detect joint effusion, and absent joint effusion rules out septic arthritis.Differential Diagnosis: Septic arthritis, the most important condition to rule out. Septic arthritis presents with toxic appearance, the hip pain is more intense and elevation of inflammatory markers is present. In transient synovitis, think about this 4 elements: Fever, weight bearing, ESR and serum WBC. Fever

There's been a growing amount of hype around the "Deca only cycle". While it is most commonly referred to as the Deca only cycle, it is actually based on the compound Nandrolone being used on its own. The decanoate ester being abbreviated as "Deca" has just become synonymous nowadays in the bodybuilding community with Nandrolone itself. Seeing the potential merits of Nandrolone as a makeshift hormone replacement therapy alternative to Testosterone, I stopped using Testosterone and instead started using Nandrolone on its own with exogenous Estradiol for 3 months and paid over $1000 for an elaborate blood panel to assess how it affected my health markers. https://youtu.be/kLScNddgkks How Nandrolone Could Potentially Be A Superior HRT Alternative To Testosterone The primitive thought process is that Nandrolone used in conjunction with Testosterone will lead to horrible side effects, but Nandrolone used on its own will just result in all of the benefits of steroids with a near absence of the androgenic or estrogenic side effects associated with Testosterone use. In reality, it's a lot more nuanced than that. The reason why I found this experiment worth pursuing is the lack of androgenicity of Nandrolone in the body. Nandrolone 5α-reduces in tissues that express 5α-reductase to the much less androgenic metabolite Dihydronandrolone (DHN). Nandrolone is basically the only anabolic steroid that is going to maintain 100% anabolic activity of the Nandrolone in muscle tissue where you want it, but also be converted into a much less androgenic metabolite with a lower binding affinity in certain areas of the body where you wouldn't want Nandrolone to bind. The two areas of concern for most individuals being hair follicles and skin. By converting to DHN in these areas, Nandrolone (and by extension DHN) causes less hair loss and acne than Testosterone (and by extension DHT). In addition, some men are genetically predisposed to high levels of aromatization and estrogen receptor expression and can't even use TRT doses of Testosterone without experiencing estrogenic side effects. Nandrolone is not a potent substrate for aromatase, and mainly converts to a weaker estrogen called Estrone (Estradiol is about 10-fold more potent than Estrone). Nandrolone is also mildly estrogenic on its own via its ability to act as an estrogen receptor alpha (ERα) agonist [R]. Overall, Nandrolone is much less androgenic and estrogenic than Testosterone, and may provide symptom relief in those seeking a viable hormone replacement therapy alternative. In this context, Nandrolone may also have great potential as an efficacious alternative to Testosterone as an anabolic agent for some individuals who are prone to androgenic and/or estrogenic side effects. The Neurotoxicity And Cardiotoxicity Of Nandrolone Based on the limited data available, Nandrolone has shown to be more deleterious to cardiovascular and neurological health than testosterone. https://www.youtube.com/watch?v=Gv_v0mJy6Bg By extrapolating the data, we start to get a clearer picture as to why this likely is. Nandrolone is mildly estrogenic on its own, and it does not aromatize nearly enough to create as much Estradiol as Testosterone does. Comparing the effect of testosterone with that of 19-nortestosterone (Nandrolone) and Stanozolol (Winstrol) on neurotoxicity we can clearly see that Estrogen is what protects neurons in the brain, not Testosterone itself. In this study, a physiologic dosage of Testosterone was neuroprotective [R]. Testosterone only amplified neurotoxicity at supraphysiological dosages. The neuroprotective effect of a physiologic dosage of Testosterone was completely eliminated when the aromatase inhibitor Anastrozole (Arimidex) was co-administered, suggesting that the intrinsic toxicity of Testosterone as an androgen is only counterbalanced by its aromatization into 17β-estradiol. As opposed to testosterone, Nandrolone does not appear to aromatize sufficiently into estrogen. As you would expect, Nandrolone was neurotoxic at every single dose evaluated regardless of Arimidex being co-administered or not. If Nandrolone was inherently able to provide enough estrogen receptor alpha (ERα) activation to balance out its androgenicity without even requiring aromatization (it acts as an estrogen on its own to some extent), we would see a neuroprotective effect at equivalent dosages to a physiologic concentration of Testosterone when no AI is used, but that does not appear to be the case either. The anti-androgen flutamide attenuated the neurotoxicity of all three androgens, thus further reinforcing that physiologic dosages of androgens without a sufficient amount of opposing estrogens, or supraphysiological dosages of androgens may facilitate neuronal death. I suspect that the same applies for the inherent cardiotoxicity of Nandrolone as well. Just because you can get your Estradiol levels up to 15 pg/mL with a gram of Deca only, that ratio of androgens to estrogen in the body is way off of what would otherwise be optimal for health based on what I've seen. This is reinforced by the fact that Flutamide (an anti-androgen) was able to attenuate the neurotoxicity of Nandrolone. By preventing Nandrolone from binding to androgen receptors, it is no longer able to transcribe its effects in tissues. Hair loss and acne are one thing, cardiotoxicity and neurotoxicity are another thing and should ultimately take precedence obviously. However, just because Nandrolone monotherapy cannot produce a sufficient ratio of androgens to estrogens, that doesn't mean that there isn't a potential loophole. That loophole is exogenous Estradiol administration. Exogenous Estradiol Use With Nandrolone Only Cycles As we've seen, Estrogen produced via aromatase is what provides neuroprotection from the androgenicity of Testosterone, not the Testosterone itself. We also know that Nandrolone is not able to produce enough estrogenic activity in the body to facilitate this same level of neuroprotection. I theorize that Nandrolone in conjunction with exogenous Estradiol to replace this otherwise missing component could attenuate a significant amount of the deleterious impact Nandrolone has on the heart and brain. In addition, by providing a sufficient amount of exogenous estrogen, libido, muscle growth, fat loss, and several other aspects of health and performance should be more optimized. It isn't a coincidence that cardiovascular disease rates skyrocket once women hit menopause and stop producing Estrogen properly. The same negative effects will apply in men with low Estrogen levels. The lack of sufficient Estrogen is often addressed in Deca only cycles by adding an adjunct anabolic steroid that aromatizes into Estrogen or Estrogen analogs. Obviously for those seeking to minimize androgenic side effects, the ideal way to go about achieving sufficient Estrogen receptor activation is probably not going to be by adding more steroids to their protocol. This is where exogenous Estradiol comes into play, and I believe the majority of Deca only cycles would be more sustainable from a health perspective, and successful in a bodybuilding context as well with its inclusion. I have yet to see one person on a Deca only cycle achieve a sufficient Estradiol level relative to their Nandrolone dosage via a sensitive assay Estradiol blood test. The following blood test result was submitted by an individual on over 1000 mg per week of Deca only. Over a gram of androgens relative to a 19.2 pg/mL Estradiol level is far from ideal in my opinion. I had a good conversation with Vigorous Steve as well about his Deca only cycle experience. He told me that his Estradiol was 12 pg/mL on 1000 mg of Deca per week after 4 weeks, and he ended up adding 25 mg DHEA per day just to bring it up to 25 pg/mL. When it comes to Nandrolone use on its own, most would benefit from more Estrogen in my opinion. My Weekly Nandrolone And Estradiol Dosage For "HRT" Most guys doing Deca only cycles are evaluating Nandrolone at dosages of 600 mg or higher per week for short blasts. My experiment was based on its potential as an alternative long term HRT option for those prone to androgenic side effects. Or alternatively, its potential as a compound to swap to periodically throughout the year from TRT to reverse some of the androgenic side effects of Testosterone and DHT while still maintaining the same amount of muscle mass. Every blood test I've seen of Deca only cycle users was on high doses of Nandrolone without a sufficient amount of Estrogen. I wanted to see how Nandrolone on its own at a "therapeutic dose" would affect my blood work if I had a sufficient amount of Estrogen provided through exogenous Estradiol. Long-term, the only way Nandrolone monotherapy could be even relatively safe in a cardiovascular context would be with exogenous Estradiol supplementation from what I've seen. And even then, I'm sure it has major drawbacks that will likely accumulate over the years. With that being said, it is still something I wanted to explore nonetheless, as it is one of the few compounds that can actually support supraphysiological muscle growth with a relatively minimal impact on androgenic alopecia. Oral micronized Estradiol tablets have quite a few drawbacks. A few of the most notable drawbacks are that oral Estrogen pills can be somewhat liver toxic, they spike SHBG through the roof, and they result in the production of clotting factors in the blood that do not develop with forms of administration that skip the first pass. The two most viable methods of administration that skip the first pass are transdermal topical application, or injection. I chose to topically apply transdermal Estradiol gel (Estrogel) for this experiment. I used 100 mg of Nandrolone phenylpropionate (NPP) per week split into daily injections using an insulin pin rotating between my glutes and ventroglutes. I also applied 2.5 grams of transdermal Estrogel (delivering 1.5 mg Estradiol) to my inner thighs every day for over 3 months straight. Blood Pressure Changes On Nandrolone One of the first things I noticed was that it was a struggle to keep my blood pressure in check on NPP, even at the mild dose I was using. What that was caused by exactly, I'm not sure. I assumed it was Aldosterone prior to this blood work. When I'm on Testosterone, even when I was using TRT as high as 200 mg per week, I could keep my blood pressure at 110/70 with ease. Even if I ate terribly, I could still hold 115/75 without even trying on Testosterone. Within the first week of switching to NPP it became way harder to control my systolic blood pressure. My diastolic blood pressure was fine for the entire 3 months, but my systolic blood pressure would consistently be around 125-128. That is not normal for me, and is borderline stage 1 hypertension. The fact that I even had to try to lower my blood pressure showed to me that Nandrolone is a lot harder to manage in this regard. This is consistent with almost every single person I know who has blasted high doses of Deca. They all had significant issues with blood pressure. Most of the guys who thought they had normal blood pressure were actually stage 1 hypertensive and didn't even realize that their results were indicative of cardiovascular stress. My 125-128 systolic occurred without being in a calorie surplus, without any weight changes, and on what I would consider a very low dose of NPP. The exact same diet, weight, lifestyle, etc. would have me at 110/70 on TRT. Muscle Growth And Strength On Nandrolone I maintained my muscle and do not feel that there was a substantial difference between the anabolic potency of Nandrolone compared to Testosterone. At the very least, the anabolic activity of Nandrolone is comparable to Testosterone, but the androgenic activity is far less than that of Testosterone. In certain contexts for certain individuals, Nandrolone will be the desirable alternative because of this. Reduced Libido On Nandrolone - Deca Dick? My libido was extremely subdued on NPP. That's one of the most obvious things I noticed during my experiment. I had a libido and would still want to have sex, but my libido was much lower than it is on regular TRT. On TRT I can barely go one day without sex before it starts to consume my mind.  On Nandrolone only, I can easily go a couple days barely even thinking about it. However, when it came time to get the job done, I could still get the job done and stay hard the entire time without any issues in erection quality. It was a bit harder to reach orgasm though. On top of the lack of androgenicity causing a reduction in libido, Nandrolone also has progestogenic activity and binds to the Progesterone receptor. Excessive Progesterone is notorious for killing libido and causing erectile dysfunction, and it seems that Nandrolone has similar effects in many individuals via this pathway in conjunction with its 5α-reduction into DHN. My drive was also lower, and I felt less aggressive overall. In many individuals Testosterone and DHT levels will strongly influence libido, drive, aggression, motivation and productivity. Personally, even if I have that support via DHT or DHT derivatives, the increased motivation and drive is actually more counterproductive in a work productivity context because my libido gets way too high. Even when I had high testosterone levels and 0 DHT in my body I still had sex on my mind far more than I would like. When that happens, I can barely get anything done, and then I end up depleting myself of energy for the day through excessive sex. The subdued and normalized libido on Nandrolone is welcomed for me because of this. I don't think this is necessarily just because I'm a good responder to Nandrolone, I think it has more so to do with the fact that I was using exogenous Estrogen during this experiment with the Nandrolone. Despite androgens driving aggression and drive, libido and erection quality is largely dictated by adequate Estrogen levels. With all that being said, DHT (with sufficient Estrogen via Testosterone aromatization) is blatantly better for sexual support than Nandrolone, and testosterone itself, even if you completely inhibited 5α-reductase and nuked DHT, still provides better libido and erection quality than Nandrolone does at equivalent "therapeutic" doses for the majority of people. My Blood Work Results On A Deca Only Cycle For HRT I don't like taking shots in the dark when it comes to something that I see potential in. There is a lot of theory thrown back and forth in the community on Deca only cycles, and I needed to see for myself how Nandrolone in conjunction with exogenous Estradiol would impact my personal blood work. I wanted to check markers of oxidative stress, inflammation, kidney function, Aldosterone, Prolactin, hormone levels via sensitive assay testing, and an array of other health markers that are often debated about but very infrequently actually tested for to reinforce statements made. Expectedly, high dose Deca only cycle blasts will almost always result in low HDL levels, subpar Estradiol levels, and an array of other out of range values that are less common and are more individual dependent. To date I have yet to see someone get their blood work checked with exogenous Estradiol being used in conjunction with Nandrolone at a "therapeutic" dose. This is what I wanted to evaluate. Complete Blood Count with Differential/Platelets I was actually expecting far worse from my blood test results. At a "therapeutic" dose, it doesn't seem like my hematology was negatively affected at all. Comprehensive Metabolic Panel In my metabolic panel, nothing was really off to the point that would cause concern. My BUN being high is likely just the result of being muscular and having a high protein diet. Lipid Panel Going into the lipid panel, we can see the number one most common blood test result among steroid users. My HDL is low. LDL is also borderline high, but not overly concerning when I can see that my Triglycerides are pretty low. The reason why my HDL was too low was that my Estrogen levels were too low. Again, this just reinforces the fact that Nandrolone does not sufficiently aromatize into Estrogen. I will get into my Estrogen level and why it was still too low even with Estrogel administration later once we get to that part of the blood test results, but my HDL could have been in range if my Estrogen level was in check. If I didn't use the Estrogel my HDL likely would have been in the single digits. I know I can get my HDL into the reference range if my estradiol levels were doubled, which I have the leeway to do. Iron And Total Iron Binding Capacity Getting into Iron and TIBC we can see that everything looks pretty normal here. Total Testosterone And Free Testosterone Expectedly, by assessing my Total Testosterone level via liquid chromatography with tandem mass spectrometry (LC/MS-MS) and my Free Testosterone level via equilibrium ultrafiltration, we can see that my Testosterone levels were crashed. Both the total and the free were lower than a healthy female. This is what you should see in your blood work if you’re on just Nandrolone. The only Testosterone being produced in my body was indirectly via the trace amounts of androgens produced in my adrenal cortex, which is why the value wasn't completely bottomed out at 0. I've mentioned many times the importance of getting high sensitivity testing done for hormone levels and how Nandrolone will register as Testosterone in primitive garbage blood tests. This is another great example of this. In addition to high sensitivity testing, I had the same blood tested using electrochemiluminescence immunoassay (ECLIA) for my Total Testosterone level, and direct analog enzyme immunoassay (EIA) for my Free Testosterone level. These were the test results using the exact same blood sample with the terrible default assays that doctors will use to determine how to treat you, and that labs will give you in the majority of your blood work panels. According to ECLIA and EIA, I have a normal Total Testosterone and Free Testosterone level. Hilarious. This just one example of why getting accurate hormone testing is critical. My Testosterone levels are actually in the gutter, but the stupid primitive tests that doctors and labs give out as defaults for people is so f*cking stupid that it can't even tell the difference between Testosterone and 19-nortestosterone in my blood. Renin Activity and Aldosterone My renin activity and Aldosterone appeared to be normal. This is one of the main things I wanted to check because there's a lot of speculation around the effect Nandrolone is going to have on Aldosterone levels. When it comes to the Deca only cycle, there's something going on that throws off homeostatic mechanisms that regulate blood pressure that does not appear to be Estrogen related or Aldosterone related. At least based on my blood work, my Aldosterone was definitely not at a level that could imply any kind of negative effect on blood pressure. My Aldosterone level was low if anything. Granted, some markers in the serum can be relatively worthless when compared to actual tissue concentrations, but at least based on my blood work, Aldosterone does not appear to be the culprit. The first thing many jump to when explaining blood pressure regulation is the effect Nandrolone supposedly has on spiking Aldosterone through the roof, but it just doesn't appear to be the case in my experience as you can see yourself here. Vitamin B12 and Folate My B12 and Folate levels were normal. Pregnenolone Pregnenolone appeared to be normal and within the reference range for men which is notable, as many assume that Nandrolone will shut down the production of precursor steroids. That does not appear to be the case either. I assumed precursor hormone levels like Pregnenolone would be less affected than many seem to think as most circulating Pregnenolone is derived from the adrenal cortex. Dihydrotestosterone (DHT) Expectedly, my DHT was very low. This is because I have almost no Testosterone being produced to 5α-reduce into DHT. If my Testosterone is low, my DHT will be low as well. DHT Backdoor Pathway Contrary to popular belief, there is a backdoor pathway via Pregnenolone that can create DHT as well, which contributes to the chunk of DHT I have in my blood. Hemoglobin A1c Hemoglobin A1c appeared to be normal at 5.1%. Thyroxine (T4) My Free T4 was 1.28 ng/dL, which is acceptable. DHEA-Sulfate My DHEA was in range and actually on the high end of normal. Being on exogenous Nandrolone or Testosterone does not shut down DHEA production. Cortisol Cortisol was "normal" apparently, although it looks a bit high to me. I believe this result was mostly sleep hygiene related rather than entirely Nandrolone related. Thyroid Stimulating Hormone (TSH) My TSH is too high. I've never had a TSH this high before. I have had a TSH in the 2's before, this isn't the first time, but never this high. However, based on my resting heart rate and my morning waking temperature and my mid-day temperature, my metabolic rate seems to be the same as it usually is on TRT, and I have had no standout hypothyroidism symptoms. Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH) Expectedly, LH and FSH were undetectable. Prolactin My Prolactin was on the low end of normal. This was another interesting health marker to see on Nandrolone, as many will often jump to assuming that Nandrolone spikes Prolactin levels through the roof. That does not appear to be the case though. Prostate-Apecific Antigen (PSA) My PSA level was normal, and did not change from my previous blood work on Testosterone for TRT. D-Dimer My D-Dimer was normal. A friend of mine had a very high D-Dimer level on a Deca only cycle and he wanted me to check mine to see if there was a pattern. It looks like the elevated D-Dimer was case-specific for him and was probably caused by something completely unrelated, as my D-Dimer is normal. C-Reactive Protein C-Reactive Protein is one of the primary markers we have for assessing inflammation in the body. A C-Reactive Protein level of 0.34 mg/L is not overly concerning, although I would like to see it below 0.3 mg/L. I had undetectable C-Reactive Protein levels in the past on TRT, and on Nandrolone it jumped up to 0.34, which is notable. Estradiol, Sensitive My Estradiol (E2) level determined via LC/MS-MS was only 15.4 pg/mL, despite administering 2.5 grams of Estrogel per day. This was disappointing, as I would have liked to see my E2 at least around 30 pg/mL based on the amount of Estrogel I was applying daily. Evidently, my inner thigh was not absorbing the Estrogel very well. This is one of the recommended areas of application, but my results were not even close to in line with the average blood levels found in the Estrogel pharmacokinetics studies. With daily administration of 2.5 g or 5 g Estrogel (corresponding to 1.5 mg or 3 mg estradiol, respectively), mean serum estradiol concentrations of approximately 80 pg/ml (294 pmol/L) and 150 pg/ml (551 pmol/L), respectively, are maintained. Administration of Estrogel also results in increased serum estrone concentrations, producing a physiological estradiol/estrone ratio of approximately one. Therefore, serum concentrations of both estradiol and estrone and the serum estradiol/estrone ratio provided by ESTROGEL® are consistent with physiological levels observed during the follicular phase of the normal menstrual cycle. My inner thigh isn't very hairy at all as I manscape fairly regularly, so I expected at least a 40 pg/mL E2 based on the amount of Estrogel I was applying. I was overly generous with my dose based on the off chance that I would encounter an absorption issue, and my E2 was still way below where I expected it to be. Based on the pharmacokinetics outlined by Merck, 80 pg/mL is the average E2 level for someone applying 2.5 grams of Estrogel per day. There's no way I could have predicted that I would have an absorption issue so problematic that it would result in five times lower absorption than the average. If my E2 was closer to 30 pg/mL, I expect that my HDL would have been pushed into the reference range, and all Estradiol driven physiologic functions likely would have been more optimized. To me, this just reinforced further that Nandrolone is a subpar source of Estradiol as I was using a high dose of transdermal E2 and still could barely reach a satisfactory E2 level. To increase my E2 levels for similar future experiments I will either have to find a better application area, add some DMSO to my Estrogel to increase absorption, or consider Estradiol injections instead. Homocysteine My Homocysteine level was higher than I would like. Normally my Homocysteine is closer to 8-8.5 umol/L. Earlier in the year when I did a shorter Nandrolone experiment for a month using 200 mg per week (double the dose I used for this experiment) I had a Homocysteine level around 8.5, so I doubt this spike was Nandrolone related. This is one of the main markers I always have my eye on because I am homozygous for the C667T polymorphism. Gamma-Glutamyl Transferase (GGT) My GGT looked good. I was worried that this would be cranked through the roof as it is a marker of oxidative stress. Magnesium My magnesium level looked okay. Copper and Zinc My zinc level looked okay. My copper level may be a bit low, which I am now addressing by eating an ounce of beef liver every day. Progesterone My Progesterone was normal, which is notable as it is another precursor hormone that many assume drops to zero when exogenous anabolic steroids are present in the body. Insulin My insulin level was good. Estrone Expectedly, my Estrone was a bit high. This can be a major problem with exogenous Estradiol and Nandrolone unfortunately. Estrone Level Increase From Exogenous Estradiol The ratio of Estrone-to-Estradiol is skewed with massive elevations in Estrone with oral Estrogen administration. Fortunately, this unhealthy ratio can be avoided for the most part with transdermal Estradiol administration. High levels of serum Estrone sulfate (E1S) were found after long-term oral estrogen treatment of commonly prescribed dosages, whereas there was a small increase in E1S levels after transdermal Estradiol (E2) therapy. The mean maximum E1S levels were more than 20-fold higher with oral estradiol (E2) when compared with the 0.05 mg/day transdermal estradiol patch. This is consistent with the 20-fold higher dose of E2 when compared with the transdermal dose [R]. Estrone Level Increase From Nandrolone Nandrolone also significantly elevates concentrations of Estrone in plasma [R]. During a pilot study evaluating the possible beneficial effect of Nandrolone Decanoate (ND) on bone metabolism in patients with rheumatoid arthritis there was a significant increase in the serum levels of Estrone [R]. Despite the fact that Estrone can convert to Estradiol, we can clearly see that the amount this actually happens in the body is minimal based on the consistently skewed ratios of androgens to Estradiol in the blood test results of Deca only users (or Nandrolone in general). Ferritin My Ferritin level is too low. This is likely the result of phlebotomizing too frequently in 2019. Estriol My Estriol level was undetectable, which was expected. Triiodothyronine (T3) My Free T3 level was 2.7 pg/mL. It's not low enough for me to be overly concerned, however, it is suboptimal and should be in the low 3's at least. This is something I will need to address moving forward. With that being said, I like to look at my resting heart rate as well as my body temperature for a more accurate assessment of my metabolism, and both are where I want them to be. My waking temperature has consistently been 98 degrees Fahrenheit, and my midday temperature has consistently been 98.6 degrees Fahrenheit. Sex Hormone-Binding Globulin Expectedly, my sex hormone-binding globulin (SHBG) was low. While this isn't as relevant for a Nandrolone only user as Nandrolone has a very low affinity for SHBG, this is a value I would still like to see in the reference range, especially if I was on TRT. If I had the Estradiol level I was shooting for, I'm confident that my SHBG would have been in the reference range. My Overall Experience On Nandrolone And Exogenous Estrogen For HRT I was expecting to see a bunch of red flags in my blood work, but nothing really stood out as a major concern to me except for the spike in systolic blood pressure, and the high Estrone level. A before and after echocardiogram and calcium scoring would have been nice to see, but unfortunately I can only afford to do so much in these experiments, and the blood work was expensive enough as is. I felt good throughout the entire experiment, I maintained my physique, my libido and penis were functional, and my blood work looked pretty good considering that each issue was something more so related to my Estradiol administration than the Nandrolone itself. Estrone being out of range is a concern, as I would need to use even more exogenous Estradiol to achieve what I would consider a more therapeutic E2 level, which would likely push my Estrone up even higher. The difficulty in controlling the blood pressure spike is also a huge concern and could be a deal breaker. If I gave this experiment more time, it is entirely possible that certain things would have become problematic that appeared to be fine during my three month assessment, like my libido or sense of well-being. It is also possible that despite maintaining a healthy Estrogen level, the same neurological and cardiovascular issues we see in a significant amount of the Nandrolone data could still accumulate over time. In addition, healthy looking serum levels of Estradiol may not necessarily reflect adequate localized Estrogen receptor activation in each tissue. With Testosterone, there is a regulated amount of aromatization occurring in each tissue to satisfy however much Estrogen receptor (ER) activation we need. In the context of Deca only cycles, or Nandrolone monotherapy, there's nothing else I can refer to other than serum levels, my libido, sense of well-being, other cardiovascular health markers, etc. In other words, just because you feel good and your Estrogen levels look good on paper, that doesn't mean that an exogenously administered source of Estrogen is providing the same therapeutic ER activation in all tissues like it would if it were regulated via aromatase. With that being said, you could also argue the opposite as adequate receptor activation via exogenous hormone therapy is essentially all HRT boils down to to begin with in the context of any hormone. More than 95% of our endogenous Testosterone is produced in the testes. Testosterone is supplied to target tissues in the blood, just like most other hormones in the body. If you inject exogenous Testosterone, it then goes into the blood and is supplied to target tissues. If you inject anything it goes into the blood and then is carried to the areas that it is needed. Estrogen replacement has been deemed satisfactory for fulfilling the same functions as endogenously produced Estrogen in women for years, and synthetic Estrogen analogs are handed out like candy to millions of young girls (including teenagers). Is it healthy? Estrogen analogs like Ethinyl Estradiol probably aren't ideal for regulating Estrogen dependent functions, and they definitely aren't ideal for developing women who haven't fully matured. However, there is tons of data to support the fact that exogenous Estradiol is well-tolerated, has a strong safety profile, and can still fulfill physiologic functions sufficiently. In an ideal world, this would be a regulated process in the body in each tissue (aromatization). My experiments do not necessarily reflect what I believe are best practice with these hormones, which should be noted. This was an experiment, and not something that I would recommend someone else do. Using an exogenous progestogen with estrogel certainly isn't what I would consider an optimal HRT protocol, or what is indicative of an ideal means of providing androgenic and estrogenic support in tissues. With that being said, I don't see a better way to go about utilizing Nandrolone on its own for HRT. Should it even be considered as an HRT alternative though? That's the question, and I believe it is largely going to be individual dependent, with a significant amount of users having poor outcomes in one aspect or another. I do believe there are a minority of individuals who are very prone to androgenic and/or estrogenic side effects from exogenous Testosterone use that may benefit from exploring Nandrolone though, and it should not be discarded as a potentially viable alternative simply because it is not the primary bioidentical hormone that men produce.

Research suggests that low carbohydrate diet can improve numerous health markers, such as triglycerides, HDL (good) cholesterol, C Reactive Protein, blood sugar, and blood pressure reducing risk factors associated with type 2 diabetes and metabolic syndrome. Other conditions that may improve include arthritis, brain fog, cognitive impairment, and digestive complaints, like GERD and IBS, if done right.

In this episode, I discuss how fasting or Fasting Mimicking Diet lowers the inflammatory marker C-Reactive Protein. Reference: https://www.ncbi.nlm.nih.gov/pubmed/26094889 YouTube: bit.ly/2JUjXVt Facebook: bit.ly/2PlIOaB Instagram: bit.ly/2OBFe7i Email List: bit.ly/2AXIzK6 Patreon: bit.ly/2OBBna0

This week on the show I talk about Glyphosate and it's remedy! Glyphosate is a toxic chemical finding it's way into our environment, food, water supply and new borns! The company Purium has released a product called Biome Medic that shows a 74% reduction of Glyphosate and 75% reduction in C-Reactive Protein in Pre-Clinical Trail. We have a solution. Are you going to take action?.........www.Ishoppurium.com.....Discount code (chrishall) $50 giftcard.......Donations: PayPal.Me/rawfoodfootsoldier.......Email: rawfoodfootsoldier@gmail.com.......Be sure to subscribe and leave a itunes review!!

Welcome back to our weekend Cabral HouseCall shows! This is where we answer our community's wellness, weight loss, and anti-aging questions to help people get back on track! Check out today's questions:  Krista: I have two questions regarding EMF exposure : 1. Do you think the EMF exposure from a fitbit (or like device) is worth it if it improves a pre-teen/teen's activity level? Any specific recommendations? 2. How do I know if a sauna is safe regarding its EMF output? I have read a few articles from those who have personally tested various saunas with widely different results. I'd like to follow your advice on taking advantage of the health benefit of infrared saunas, but am confused as to how to make sure the EMF levels are safe. Thanks as always! Chris: Can you point me in the right direction in terms of chronic MAC infection of the lungs? My mother was diagnosed many years ago but things have escalated quite a bit in the past few months. She has a constant dry cough, fatigue, lack of appetite, etc. Her escalated symptoms began a few months after moving to a different house. I suspect something about the new house may be a factor.Thank you, Chris Beth: Hello Dr. Cabral. Love your podcast! I have learned so much from you and I continue to learn daily the more I listen. I'm hoping you can help point me in the right direction with this...but I have been dealing with clogged ears for the last several months. A bit of backstory to assist, back in August of 2018 I decided to take some strong antibiotics (Flagyl to be exact) in order to combat a bacterial overgrowth (please note I am health conscious and so I rarely got sick or had to deal with any health related issues prior to this). During the time I was taking the 10-day antibiotics, I got sick with what seemed to be bronchitis. While sick, I took a flight for a vacation we had planned and my ears refused to pop. It was as if the congestion from the cold or whatever I had was pushed into my ear canals. Ever since, not only have I been sick multiple times (one time resulted in IV fluids, steroids and more antibiotics), but my ears have never recovered. I know that taking the antibiotics was a horrible idea, no matter how desperate, because it destroyed all the good bacteria I had in my gut and left me completely susceptible to everything. I went to the ENT and was told my hearing was perfect and that my ears were clear, yet I still can't pop them. I feel a bit unbalanced and my ears feel full and muffled. And if I eat anything inflammatory, my right side starts hurting. On top of that, I have ongoing "post-nasal" drip feeling in the back of my throat, which again, worsens with inflammatory foods like sugar. Any suggestions you may have to help me heal are greatly appreciated! Thank you for all you do! Tony: Hi Dr. Cabral, Love your DESTRESS protocol and all your work, however, what seems to be missing is a focus on trauma.What are your thoughts on those who's health have plateau'd because of childhood trauma that has conditioned such strong subconscious beliefs, that even the Monday Motivations aren't resonating with these conditioned core beliefs?There are modalities like EMDR, but I'm curious on your take and what you see in your practice, as I put Cabral and his team as the gospel of truth on health, wellness, and spirituality :) Keep up the fantastic content! Annette: Hi Dr. Cabral.Thank you for sharing your wonderful knowledge in the world. I would like to know some information regarding hair loss. I'm considering ordering some of your tests but don't know which one would be appropriate for me. I'm going to be 45 years old and in the last few years I've lost maybe half of my hair... the loss continues... and every time that is my hair wash day I just get so scared and anxious thinking "how much hair I will lose again today!” I do not take birth control. I'm vegetarian but do not eat eggs. My TSH level is 1.42 and my C-Reactive Protein level is 0.8 and total Protein level is 7.1 I would love to get some guidance and advice as to what I should do and what might cause my hair loss issue. ( Am I premenopausal?) It's to a point that I can not leave my hair loose. Thank you so very much for your help and time.Annette Joanna: Hi Dr Cabral I have a few questions.1. What would you suggest for ovarian cysts and what can cause this? 2. Iv been having upper left abdominal bloating for a few months now usually after eating or if im a little stressd around where the stomach is situated i think i may gastritis or bile reflux. I have candida and bacterial overgrowth high histamine issues and currently doing the CBO. What do you suggest i can do to heal this naturally. I want to avoid a endoscopy if i can? 3. What are your thoughts on slippery elm in healing the gut and even treating gastritis. thanks im currently doing IHP and post regularly on the facebook groups. Many thanks for all you do joanna from australia :)   Thank you for tuning into today's Cabral HouseCall and be sure to check back tomorrow where we answer more of our community’s questions!  - - - Show Notes & Resources: http://StephenCabral.com/1205 - - - Get Your Question Answered: http://StephenCabral.com/askcabral   - - - Dr. Cabral's New Book, The Rain Barrel Effect https://amzn.to/2H0W7Ge - - - Join the Community & Get Your Questions Answered: http://CabralSupportGroup.com - - -   Dr. Cabral’s Most Popular Supplements: > “The Dr. Cabral Daily Protocol” (This is what Dr. Cabral does every day!) - - - > Dr. Cabral Detox  (The fastest way to get well, lose weight, and feel great!) - - - > Daily Nutritional Support Shake  (#1 “All-in-One recommendation in my practice) - - - > Daily Fruit & Vegetables Blend  (22 organic fruit & vegetables “greens powder”) - - - > CBD Oil  (Full-spectrum, 3rd part-tested & organically grown) - - - > Candida/Bacterial Overgrowth, Leaky Gut, Parasite & Speciality Supplement Packages - - - > See All Supplements: https://equilibriumnutrition.com/collections/supplements  - - -   Dr. Cabral’s Most Popular At-Home Lab Tests: > Hair Tissue Mineral Analysis (Test for mineral imbalances & heavy metal toxicity) - - - > Organic Acids Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Thyroid + Adrenal + Hormone Test  (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Adrenal + Hormone Test (Run your adrenal & hormone levels) - - - > Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Omega-3 Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - > Stool Test (Use this test to uncover any bacterial, h. Pylori, or parasite overgrowth) - - - > Genetic Test (Use the #1 lab test to unlocking your DNA and what it means in terms of wellness, weight loss & anti-aging) - - - > Dr. Cabral’s “Big 5” Lab Tests (This package includes the 5 labs Dr. Cabral recommends all people run in his private practice) - - - > View all Functional Medicine lab tests (View all Functional Medicine lab tests you can do right at home for you and your family!)

Doctors looking after newborn babies need to be able to detect infections early and accurately if they are to prevent the baby from becoming seriously ill. One of the tests suggested for doing this is to measure their c-reactive protein and this was assessed in a new Cochrane Review in January 2019. We asked the lead author, Jennifer Brown from the Centre for Reviews and Dissemination at the University of York in the UK, to tell us why this review is so important and what it found.

Doctors looking after newborn babies need to be able to detect infections early and accurately if they are to prevent the baby from becoming seriously ill. One of the tests suggested for doing this is to measure their c-reactive protein and this was assessed in a new Cochrane Review in January 2019. We asked the lead author, Jennifer Brown from the Centre for Reviews and Dissemination at the University of York in the UK, to tell us why this review is so important and what it found.

Doctors looking after newborn babies need to be able to detect infections early and accurately if they are to prevent the baby from becoming seriously ill. One of the tests suggested for doing this is to measure their c-reactive protein and this was assessed in a new Cochrane Review in January 2019. We asked the lead author, Jennifer Brown from the Centre for Reviews and Dissemination at the University of York in the UK, to tell us why this review is so important and what it found.

This podcast covers the JBJS issue for July 2018. Featured are articles covering Percutaneous Needle Fasciotomy Versus Collagenase Treatment for Dupuytren Contracture; recorded commentary by Dr. Slater; Postoperative Glucose Variability Associated with Adverse Outcomes of Total Joint Arthroplasty; Risk-Based Hospital and Surgeon-Volume Categories for Total Hip Arthroplasty; recorded commentary by Dr. Vail; Alpha Defensin and C-Reactive Protein in the Diagnosis of Periprosthetic Joint Infection.

This podcast covers the JBJS issue for July 2018. Featured are articles covering Percutaneous Needle Fasciotomy Versus Collagenase Treatment for Dupuytren Contracture; recorded commentary by Dr. Slater; Postoperative Glucose Variability Associated with Adverse Outcomes of Total Joint Arthroplasty; Risk-Based Hospital and Surgeon-Volume Categories for Total Hip Arthroplasty; recorded commentary by Dr. Vail; Alpha Defensin and C-Reactive Protein in the Diagnosis of Periprosthetic Joint Infection.

In this episode we talk about Five important blood tests that you should ask your doctor to order. These tests aren't typically ordered unless requested even though they can provide a lot of important information about your health. We talk about Triglycerides, C-Reactive Protein, Vitamin D Level, Omega-3 level, HA1C.

Organifi Quah! In this episode of Quah, sponsored by Organifi (organifi.com, code "mindpump" for 20% off), Sal, Adam & Justin answer Pump Head questions about if ab work is necessary if you are doing foundational lifts, if eating fruit is essential, whether women crave sweets more than men and if it is ok to hit on a guy in the gym. Nothing can mask symptoms better than Western Medicine. Sal is full blown sick, he shares all the drugs he is on and how he is refusing to take antibiotics. (5:04) The greater the challenge the greater the growth. Sal's Keith Richards drug theory, Adam's drug/genetics theory and why drugs do affect certain people more than others. (7:29) An altered state of conscious. The guys share their worst drug experiences. (14:40) The Daily Pump - Current Events: The Jersey Shore re-boot! Joey Swoll's rebranding/snake oil salesman still exists and the guys discuss Mike “The Situation” connection to Shredz. (24:45) Still drinking bottled water? Sal shares a recent article how the bottled water you are drinking may contain particles of plastic. (31:48) The Death of Satellite Radio. Largest US radio company iHeartMedia files for bankruptcy (34:20) Trump's moon base. Star Wars is here! (36:45) The First Hamburger Flipping Robot here?! Our all jobs soon going to be automated? (38:00) Toys R Us to close all of their stores. How challenge gives life meaning. Are our children these days spoiled by technology? (40:20) Comparison is the thief of joy. Is there a psychological problem of living near people who have more than you do? Guys go deep into if Keeping up with the Joneses is reality. (45:00) Quah question #1 – Is direct ab work necessary if you are doing foundational lifts? (49:08) Quah question #2 – Is eating fruit essential? (1:02:25) Quah question #3 – Do women crave sweets more than men? (1:11:21) Quah question #4 – Is it ok to hit on a guy in the gym? (1:22:45) Related Links/Products Mentioned: Vuori Clothing Methylone Why Is Salvia Such a Uniquely Terrifying Drug? Effects of Chronic, Heavy Cannabis Use on Executive Functions Ephedra and Its Application to Sport Performance: Another Concern for the Athletic Trainer? Ephedra: Is It Worth the Risk? Yellow Jacket marketing declared illegal by FDA The Situation From Jersey Shore Tries To Crack Jokes On Live TV That Bottled Water You're Drinking May Contain Tiny Particles of Plastic MiiR | Product to Project™ Microplastics and human health—an urgent problem Largest US radio company iHeartMedia files for bankruptcy Spotify's new UI is for new users only (for now) Trump's 'Back to the Moon' Directive Leaves Some Scientists with Mixed Feelings Hamburger flipping robot fired after two days at work as human staff could not keep up with it Toys R Us to close all 800 of its U.S. stores Link Between Wealth And Suicide Rates Organifi ** Use the code “mindpump” for 20% off** No BS 6-Pack AB Formula - Mind Pump Strongman Robert Oberst Responds to Your YouTube Comments How to Do the Swiss Ball Crunch | C.H.E.K INSTITUTE How Color Vision Came to the Animals Human Color Vision Evolved to See Blood and Ripe Fruit The effects of pomegranate extract on blood flow and running time to exhaustion Clinical investigation of the acute effects of pomegranate juice on blood pressure and endothelial function in hypertensive individuals Regular Consumption of Dark Chocolate Is Associated with Low Serum Concentrations of C-Reactive Protein in a Healthy Italian Population Estrogen Actions in the Brain and the Basis for Differential Action in Men and Women: A Case for Sex-Specific Medicines Sal's “White Paper” People Mentioned: Joey Swoll (@joeyswoll)  Instagram Mike The Situation (@ItsTheSituation)  Twitter Ryse Supplements (@ryse_supps) Instagram Howard Stern (@HowardStern) Twitter Donald J. Trump (@realDonaldTrump)  Twitter Robert Oberst (@robertoberst)  Instagram Paul Chek (@paul.chek)  Instagram Craig Capurso (@craigcapurso)  Instagram Kyle Kingsbury (@Kingsbu) Twitter/Instagram Max Lugavere (@maxlugavere)  Instagram Ben Greenfield (@bengreenfieldfitness) Instagram Jessica Rothenberg (@thetraininghour) Instagram Also check out Thrive Market! Thrive Market makes purchasing organic, non-GMO affordable. With prices up to 50% off retail, Thrive Market blows away most conventional, non-organic foods. PLUS, they offer a NO RISK way to get started which includes: 1. One FREE month's membership 2. $20 Off your first three purchases of $49 or more (That's $60 off total!) 3. Free shipping on orders of $49 or more How can you go wrong with this offer? To take advantage of this offer go to www.thrivemarket.com/mindpump You insure your car but do you insure YOU? If you don't, and you are the primary breadwinner, you will likely leave your loved ones facing hardship and struggle if you die (harsh reality). Perhaps you think life insurance is expensive, but if you are fit and healthy, you can qualify for approved rates that are truly inexpensive and affordable. To find out if you qualify for the best rates in the industry, go get a quote at www.HealthIQ.com/mindpump Would you like to be coached by Sal, Adam & Justin? You can get 30 days of virtual coaching from them for FREE at www.mindpumpmedia.com. Get our newest program, MAPS HIIT, an expertly programmed and phased High Intensity Interval Training program designed to maximize fat burn and improve conditioning. Get it at www.mindpumpmedia.com! Get MAPS Prime, MAPS Anywhere, MAPS Anabolic, MAPS Performance, MAPS Aesthetic, the Butt Builder Blueprint, the Sexy Athlete Mod AND KB4A (The MAPS Super Bundle) packaged together at a substantial DISCOUNT at www.mindpumpmedia.com. Make EVERY workout better with MAPS Prime, the only pre-workout you need… it is now available at mindpumpmedia.com Have Sal, Adam & Justin personally train you via video instruction on our YouTube channel, Mind Pump TV. Be sure to Subscribe for updates. Get your Kimera Koffee at www.kimerakoffee.com, code "mindpump" for 10% off! Get Organifi, certified organic greens, protein, probiotics, etc at www.organifi.com Use the code “mindpump” for 20% off. Go to foursigmatic.com/mindpump and use the discount code “mindpump” for 15% off of your first order of health & energy boosting mushroom products. Add to the incredible brain enhancing effect of Kimera Koffee with www.brain.fm/mindpump 10 Free sessions! Music for the brain for incredible focus, sleep and naps! Also includes 20% if you purchase! Please subscribe, rate and review this show! Each week our favorite reviewers are announced on the show and sent Mind Pump T-shirts! Have questions for Mind Pump? Each Monday on Instagram (@mindpumpmedia) look for the QUAH post and input your question there. (Sal, Adam & Justin will answer as many questions as they can)

"Just because you have genetic markers for things doesn't mean you necessarily have associated risks as long as you are eating real foods." – Dr. Will Cole If you are interested in the low-carb, moderate protein, high-fat, ketogenic diet, then this is the podcast for you. We zero in exclusively on all the questions people have about how being in a state of nutritional ketosis and the effects it has on your health. There are a lot of myths about keto floating around out there and our two amazing co-hosts are shooting them down one at a time. Keto Talk is co-hosted by 10-year veteran health podcaster and international bestselling author Jimmy Moore from “Livin’ La Vida Low-Carb” and Pittsburgh, PA functional medicine practitioner Dr. Will Cole from DrWillCole.com who thoroughly share from their wealth of experience on the ketogenic lifestyle each and every Thursday. We love hearing from our fabulous Ketonian listeners with new questions–send an email to Jimmy at livinlowcarbman@charter.net. And if you’re not already subscribed to the podcast on iTunes and listened to the past episodes, then you can do that and leave a review HERE. We’ve made it to 100 episodes, thanks to YOU! Listen in today as Jimmy and Will chew the keto fat in Episode 103. HERE’S WHAT JIMMY AND WILL TALKED ABOUT IN EPISODE 103: RESERVE YOUR TICKETS AT KETOFEST.COM NOTICE OF DISCLOSURE: Paid sponsorship "Just because you have genetic markers for things doesn't mean you necessarily have associated risks as long as you are eating real foods." – Dr. Will Cole YOUR NEW KETO DIET ALLY NOTICE OF DISCLOSURE: Paid sponsorship – HEALTH CRAZE HAS DANGEROUS IMPLICATIONS – Chestertown dietitian offers help with weight loss – Stop Blaming People for Being Fat! – The fight against 'fake meat' has officially begun  – Meat Madness: Americans Expected To Eat Record Amounts Of Protein In 2018 – Does giving blood temporarily reduce blood ketone levels? Why does this happen? MAKE KETO EASIER WITH FBOMB NOTICE OF DISCLOSURE: Paid sponsorship Hi Jimmy and Will, I’m a long time listener and really enjoy the wisdom and experiences you guys share. You both do such a great job! I started eating keto in January 2017. Unfortunately I wasn’t too strict last year with way too many “cheats” and I had a terrible time breaking my sugar addiction. Still I dropped 30 pounds in the first 2 months. I also do intermittent fasting and short extended fasts. I very gradually dropped another 10 pounds since then for a total of 40. I’m 58 years old and at 5’9” weigh 158 pounds. That’s probably where I was in high school and I feel great in so many ways! At the beginning of this year I gave a renewed effort to be strict with my keto and IF and have had pretty good success. I purchased a blood ketone meter from BestKetoneTest.com and I test daily to stay in nutritional ketosis. A few days ago, we had a blood drive in our community and I donated as I normally do. Before donating I had regularly been in the 3.0 blood ketone range. The morning after donating I dropped to 1.1, but then the following morning I was back to 3.1. My eating stayed the same and there were no other changes. While I’m not concerned, I am very curious about this—does donating blood affect ones ketone levels? Thanks again for all you guys do! Rich "They pretend that carbohydrate is the only source of glucose, but your body can make it from your dietary protein just fine." – Jimmy Moore – STUDY: Study Finds Food Quality Matters For Weight Loss, Not Calories THE PERFECT KETO SUPPLEMENT USE COUPON CODE LLVLC FOR 15% OFF NOTICE OF DISCLOSURE: Paid sponsorship 1. Why do I have a strong ammonia smell after exercising? Is it the acetone indicating deep ketosis? Dear Jimmy and Will, I am a 49-year old man who has been low-carb/keto for 2 years and I’ve lost 50 pounds and have kept it off. I don’t measure ketones because I don’t suffer from metabolic syndrome or diabetes so I can’t justify the expense of a breath meter or the pain of a finger prick. However, based on energy level, constant satiety, and mental clarity I’m pretty sure I am in ketosis more often than not. I recently started taking hour long walks at a brisk pace and transitioned to interval sprints with a goal of eventually running a 5K. At the end my last two sessions I smelled a strong ammonia scent. What does this mean? Online forums mentioned the following words and phrases: burning protein as fuel, amino acids, urea, nitrogen, uric acid, low glucose/glycogen levels in the muscles, and wait for it….kidneys! Am I doing more harm than good by exercising? Could the scent be an indication that I am in deep ketosis? Am I smelling acetone as a byproduct instead of ammonia? One forum mentioned the cure to the ammonia smell is to eat more carbs! Not going to happen! What gives? Love your show and your other platforms? Thanks, Ken 2. Why does my keto husband get tingling hands while sleeping? Why do I have an itchy scalp while eating ketogenic? Hi Jimmy and Dr. Cole, I listen to you guys often. Thanks for everything you do. I have a couple of questions for you guys: 1. When my husband eats strict keto, his hands tingle and go numb especially when sleeping. The strange thing is if he eats lots of carbs this doesn't happen. He supplements with potassium and magnesium, but it isn't helping. 2. I have eaten a strict keto diet for 18 months with no cheating with junk food. I have a bad itch towards the front of my scalp. It’s not dandruff, just a bad itch. Is this related to my ketogenic diet? Thank you for your help with my questions. Erin BECOME A NUTRITIONAL THERAPY PRACTITIONER Sign up by February 2018 for the 9-month program NOTICE OF DISCLOSURE: Paid sponsorship 3. Why has my fasting insulin and hsCRP levels increased since adopting a ketogenic diet? Hi Jimmy and Will, I just had some blood work done and my lipid panel looks worse, although I understand that this isn't uncommon when you’re losing weight following a ketogenic diet. Maria Emmerich stated in one of her books that all the excess fat from the fat cells gets released into the blood when you go keto. So, that part makes some sense to me. However, my fasting insulin has also increased (it was 10 in June 2016 and is now 13) and my C-Reactive Protein reading is also dramatically higher (1.6 in June, now 7.7). I'm mostly just shocked about the fasting insulin since I'm not eating hardly any carbs at all and no sugar. I'd be interested to hear any ideas you might have. I eat chicken or beef (homemade) bone broth regularly, Sauerkarut (no sugar) regularly, avocados almost daily, red leaf lettuce salad with black olives, some onion (white or green) with Primal Kitchen Ranch dressing almost daily, free range eggs, grass fed meats whenever possible, Wellshire sugar-free bacon, grass-fed ghee, coconut oil, avocado oil, Chai tea sweetened with Stevia with whipping cream (grass-fed), Lakanto monkfruit chocolate, cheeses from grass-fed cows, some beets, Miracle Noodles from time to time, and ketogenic wine usually only once per week. That's pretty much the extent. No fruit, no starchy vegetables. I usually don't eat until about noon every day and try not to eat after 6:30 pm. Thank you, Shelley KETO TALK MAILBOX – What is the criteria for a well-formulated ketogenic diet? We throw around “a well formulated keto diet” but I’m actually having trouble finding criteria for “well formulated.” Is there an agreed-upon definition? Dr. Jim Small, MD NOTICE OF DISCLOSURE: Paid sponsorship Apple Podcasts reviews:   LINKS MENTIONED IN EPISODE 103 – SUPPORT OUR SPONSOR: Register now for Ketofest at ketofest.com – SUPPORT OUR SPONSOR: Staying in ketosis just got easier – Your new keto-diet ally (Enter MOORE15 at checkout for fifteen percent off your first order.) – SUPPORT OUR SPONSOR: Drop an FBOMB for the freshest, high-quality fats from JimmyLovesFBomb.com (Get 10% off your first food order with coupon code “JIMMYLOVESFBOMB”) – SUPPORT OUR SPONSOR: Jump start your ketogenic diet with PerfectKeto.com/Jimmy (USE PROMO CODE LLVLC FOR 15% OFF) – SUPPORT OUR SPONSOR: Become A Nutritional Therapy Practitioner – SUPPORT OUR SPONSOR: The perfect keto-friendly snack with 85% FAT (Use coupon code JIMMY to get 15% off your order of Gra-POW!) – HEALTH CRAZE HAS DANGEROUS IMPLICATIONS – Chestertown dietitian offers help with weight loss – Stop Blaming People for Being Fat! – The fight against 'fake meat' has officially begun  – Meat Madness: Americans Expected To Eat Record Amounts Of Protein In 2018 – Does giving blood temporarily reduce blood ketone levels? Why does this happen? – STUDY: Study Finds Food Quality Matters For Weight Loss, Not Calories – Jimmy Moore from “Livin’ La Vida Low-Carb” – DR. Will Cole D.C. from DrWillCole.com    

For Episode 385 of The Paleo Solution Podcast we have a special guest: Dr. Shawn Baker M.D. Dr. Baker is an orthopedic surgeon, multiple record breaker in weightlifting, and has been eating a carnivore diet for the last 15 months. Listen in as we talk about all-meat diets, and go over Dr. Baker's recent blood work results. Show Notes: 1:50 – Opening Remarks/Summary 3:48 – Dr. Shawn Baker’s background 6:15 – All carnivore diets (and health and autoimmune disease) 12:46 – Athletics eating carnivore diet 14:45 – Concept 2 Rower 17:28 – Blood sugar swings 18:20 – Carnivore diet controversy and comparing to keto and mixed diets. 20:02 – mTOR and protein discussion 22:14 – Muscle mass and longevity 23:13 – Dr. Shawn Baker’s blood work 25:20 – C-Reactive Protein 27:10 – Fasting Glucose 30:15 – Blood Urea Nitrogen (BUN) 30:39 – Creatinine 30:50 – Cholesterol (general panel) 32:37 – Liver function (AST and ALT) 33:57 – More Cholesterol discussion 35:50 – Testosterone 40:38 – A1c 42:42 – Ferritin 44:21 – Iron related 45:57 – Insulin 47:55 – LDL-P 48:40 – LPIR score 48:55 – TSH 49:02 – Vitamin D 50:08 – Remnant cholesterol particles 50:41 – BMI 50:55 – Blood pressure 51:05 – HDL to Triglyceride ratio 53:09 – Lp(a) 54:54 – More LDL-P and cholesterol discussion (reverse discordance) 56:15 – More discussion on glucose (athletics and glucose) 59:05 – Where is Dr. Baker taking this next? (and salt and muscle pump) 1:01:05 – Fiber 1:02:26 – Fruits and vegetables 1:03:43 – Experimentation, science, and progression 1:08:51 – Where you can find Dr. Shawn Baker   Instagram: @ShawnBaker1967 Twitter: @SBakerMD World Carnivore Tribe Facebook Group MeatHeals.com Carnivore Training System https://nequalsmany.com/ Dr. Shawn Baker on the Joe Rogan Experience podcast: http://podcasts.joerogan.net/podcasts/dr-shawn-baker  

If you are interested in the low-carb, moderate protein, high-fat, ketogenic diet, then this is the podcast for you. We zero in exclusively on all the questions people have about how being in a state of nutritional ketosis and the effects it has on your health. There are a lot of myths about keto floating around out there and our two amazing cohosts are shooting them down one at a time. Keto Talk is cohosted by 10-year veteran health podcaster and international bestselling author Jimmy Moore from “Livin’ La Vida Low-Carb” and Pittsburgh, PA functional medicine practitioner Dr. Will Cole from DrWillCole.com who thoroughly share from their wealth of experience on the ketogenic lifestyle each and every Thursday. We love hearing from our fabulous Ketonian listeners with new questions–send an email to Jimmy at livinlowcarbman@charter.net. And if you’re not already subscribed to the podcast on iTunes and listened to the past episodes, then you can do that and leave a review HERE. Listen in today as Jimmy and Will peel back the layers of your low-carb, high-fat, ketogenic questions in Episode 85. BECOME A NUTRITIONAL THERAPY PRACTITIONER Sign up by February 2018 for the 9-month program NOTICE OF DISCLOSURE: Paid sponsorship *****SPECIAL THANKS to Jordan******   Go to PayPal.me/KetoTalk to make a donation.  You can set up automatic monthly payments there THE PERFECT KETO SUPPLEMENT USE COUPON CODE LLVLC FOR 15% OFF NOTICE OF DISCLOSURE: Paid sponsorship   KEY QUOTE: “Food comes first. I don't think you can supplement your way into an optimum, healthy, ketogenic diet.” — Dr. Will Cole MAKE KETO EASIER WITH FBOMB JIMMYLOVESFBOMB FOR 10% OFF YOUR FIRST FOOD ORDER NOTICE OF DISCLOSURE: Paid sponsorship Here’s what Jimmy and Will talked about in Episode 85: RESPONSE FROM A LISTENER: Hey, Jimmy and Dr. Cole, I listened to your discussion in Episode 81 of Keto Talk about the difficulty in getting life insurance and I wanted to let you know that there are actually carriers that will issue up to $1 million policies up to the best rating class without having to go through any blood/urine profile or physical exam. If they are healthy and between the ages of 18-54 and have not been declined or rated from a life insurance carrier before, this option is available. It could be a good fit for someone that thinks their blood levels may be "abnormal" from the insurance company perspective and want to avoid doing labs. Just an FYI for people to talk to their insurance broker about this. Thanks, Justin HOT TOPICS: Zero carb diets Exogenous ketones To Test or Not To Test For Ketones Join The Keto Clarity Club For $1 Blood Ketone Test Strips!   – That keto diet you think is working wonders could kill you – Furore over ketogenic diet – The Silicon Valley execs who don't eat for days: 'It's not dieting, it's biohacking' – Mick Jagger gets satisfaction from diet that could add 10 years to his life KEY QUOTE “If you're eating zero-carb, make sure you're eating nose to tail to ensure you are getting all the micronutrients you need.”  – Jimmy Moore – Why am I having painful leg cramps while on keto outside of electrolyte imbalance? How do you resolve them without supplementation? Hi, Jimmy and Dr. Cole, I love this podcast, been listening since Day 1. I’ve been eating low-carb for several years and about a year and a half ago I went full-on keto. I love this way of eating and have seen a lot of benefits from it. I regularly see average ketones of 1.7 mmol/L. However, there is one drawback I experience at least once a week and upwards of four times a week. It’s the dreaded leg cramps. They are more common at night, often when I’m sleeping, but I’ve experienced them pretty much anytime throughout the day. I believe the ketogenic lifestyle truly is the ideal way to eat, but I shouldn’t be having this major and often quite painful side effect, right? I’ve heard you discuss the issue of muscle cramps in the past and how they’re typically due to dehydration and/or electrolyte depletion or imbalance. The quandary I now have is how can I really consider this ketogenic diet to be “ideal” if it leaves me with this leg cramp issue that I seemingly have to solve with supplementation. Obviously, if this way of eating was being implemented by our ancestors and it was causing them this problem, they wouldn’t have been able to solve it with supplements. I don’t have any major health issues and am not metabolically broken. But this nagging problem with my ketogenic diet makes me wonder how it can truly be the perfect way to eat? Any ideas why my electrolytes may be out-of-whack and leading to leg cramps? Or could the cramps possibly be due to something else I’m not aware of? I appreciate your help. Keep up the good work! Brian   – STUDY: Red meat halves risk of depression 1. Why am I experiencing a sudden dip in my energy levels while eating ketogenic when energy has been great? Dear Jimmy and Will, I’ve been following the ketogenic diet for nearly a year at the age of 75 and have experienced great energy eating grass-fed meats, fresh farm eggs, and organic vegetables. But over the past month I’ve noticed my energy has taken a dive and I thought it might be the heat of the summer. But my blood pressure also dropped so low (70/42) that I had a tough time just standing up. My doctor had me wear a heart halter and discovered I have tachycardia. Of course, now I have to see a cardiologist and I’m sure he’s gonna flip out about my numbers eating keto: Total cholesterol 294, LDL-C 198, HDL-C 85, triglycerides 55, LDL-P 2100, small LDL-P 386, VLDL 11, fasting blood glucose 90, Vitamin D 97.0, C-Reactive Protein 1.1 Do you have any suggestions for me? Brenda   2. Is there concern about a low Vitamin C intake while eating a restricted ketogenic diet like the one outlined in The Plant Paradox? Hi, Jimmy and Dr. Cole, A friend of mine read the book The Plant Paradox by Dr. Steven Gundry and is following his dietary advice. After reviewing their recommendations (essentially no legumes, no grains, low/no fruit, no vegetables that contain seeds on the inside like cucumbers, squash, etc) it seems that she would easily fall into the ketogenic diet recommendations. She recently met with her naturopath who was leery of keto because of a supposedly low vitamin C intake. Do you have any insight into this and how a ketogenic dieter would get Vitamin C? I usually follow a Paleo/keto diet but have never considered micronutrient deficiencies as a concern because I am eating so much plant matter. Thank you in advance! Alexandria 3. How do I avoid the onslaught of sugar and crappy carbage while I am in the hospital? Will they honor my request to keep the sugar and carbs out of my diet? Hey guys, What is a patient who eats keto supposed to do when they are in the hospital? I need to have aortic heart valve and stem replacement surgery someday and I worry about what this hospital stay will do to me. I’m a severely insulin resistant Type 2 diabetic who had an A1c of 10.4 prior to going on a ketogenic diet. Three months after going keto, that number dropped to 5.6. I’m keto for life now, but this hospital stay will be a challenge to avoid the crappy carbage they like to serve as well as the sugar-filled goop they put in the feeding tubes. I already know my healing won’t happen properly with high blood sugar and insulin levels and the hospital will simply medicate and inject me with insulin to deal with it. If I asked my hospital to avoid doing this, will they follow my wishes? I suppose I could just fast the entire time I am in the hospital, but do you have any suggestions about this? Thanks so much for helping me with this. Ethan KETO TALK MAILBOX – Does a ketogenic diet help or hurt with anxiety issues? Hey Jimmy and Will, I just found and subscribed to Keto Talk—thank you for the great information! I’m thinking seriously about getting into the keto thing for myself, but I am doing my homework first. I am a 61-year-old carb addicted female who needs to lose at least 50 pounds. I was recently diagnosed as pre-diabetic and I want to get myself back to feeling happy and well again. My question for you guys revolves around how keto helps with anxiety issues. Is there any medical, scientific, or other data with ketogenic diets and anxiety? Or does it make anxiety worse (ugh…I hope not)? Thank you again! Kim iTunes reviews:   LINKS MENTIONED IN EPISODE 85 – SUPPORT OUR SPONSOR: Join Jimmy Moore’s Keto Support Group: KetoClarityAcademy.com – SUPPORT OUR SPONSOR: Join The Keto Clarity Club For $1 Blood Ketone Test Strips! BestKetoneTest.com – SUPPORT OUR SPONSOR: The world’s freshest and most flavorful artisanal olive oils. Get your $39 bottle for just $1. – SUPPORT OUR SPONSOR: Become A Nutritional Therapy Practitioner – SUPPORT OUR SPONSOR: Jump start your ketogenic diet with PerfectKeto.com/Jimmy (USE PROMO CODE LLVLC FOR 15% OFF) – SUPPORT OUR SPONSOR: Drop an FBOMB for the freshest, high-quality fats from JimmyLovesFBomb.com (Get 10% off your first food order with coupon code “JIMMYLOVESFBOMB”) – That keto diet you think is working wonders could kill you – Furore over ketogenic diet – The Silicon Valley execs who don't eat for days: 'It's not dieting, it's biohacking' – Mick Jagger gets satisfaction from diet that could add 10 years to his life – STUDY: Red meat halves risk of depression – Jimmy Moore from “Livin’ La Vida Low-Carb” – DR. Will Cole D.C. from DrWillCole.com – HELP KEEP KETO TALK ON THE AIR: MAKE A DONATION HERE

Join Our Beta Program Community - Here! - The next gene to be put under our spotlight is CRP. This gene affects both the aerobic trainability and recovery aspects of our report, as well as playing a role in the our Peak Performance algorithm. Small changes within this gene cause changes in the amount of CRP we would expect each person to have, both at baseline and following exercise. CRP stands for C-Reactive Protein, which is a marker for inflammation. The greater the amount of CRP a person has, typically the more inflammation they have. Research indicates that higher amounts of CRP are associated with lower levels of aerobic fitness (as measured by VO2max). Research typically shows that G allele carriers of the CRP SNP we are interested in will typically have higher levels of CRP both at baseline and after exercise, which could affect how much they will improve following aerobic endurance based training – typically we would expect smaller improvements in these people. The opposite is also true; A allele carriers of CRP will be more likely to see greater improvements in aerobic capacity, and better improvements from endurance training than G allele carriers.  CRP is also released after exercise, and again G allele carriers are likely to have a higher amount of CRP following exercise. This causes a greater amount of inflammation, which in turn means it can take longer for recovery to occur. Because of this, we will class people with at least one G allele as having a slower recovery speed than AA genotypes. The good news is that small changes in our diet can have a really positive effect on lowering CRP levels and improving recovery. A 2003 study looked at the effect of a supplement containing omega-3, vitamin E and polyphenols (nutrients found in fruits and vegetables) on CRP release following exercise. What the researchers found is the less CRP was released following exercise when the supplement was taken, and this helped recovery; those taking the supplement saw shorter recovery times. So, if we know you’re likely to have higher levels of CRP following exercise, we would recommend that you consume higher amount of antioxidants through fruits and vegetables, as well as fish oils, in order to improve your recovery speed. In summary, a polymorphism within the CRP gene can affect how well you recover from exercise, as well as affecting improvements from exercise. CRP genotype Power-Endurance / VO2max Recovery Speed AA 4:35 Associated with lower levels of CRP, which in turn is associated with a better VO2max response to training Associated with lower levels of inflammation after hard training sessions, leading to quicker recovery times. AG 4:56 Intermediate CRP levels, and some benefits in VO2max response to training. May experience moderately increased levels of inflammation following strenuous exercise. A longer rest period may be required between training sessions when compared to AA genotypes. GG 5:24 Associated with higher levels of CRP, and therefore inflammation, following exercise. In turn, this is associated with a lower VO2max response to exercise. May experience higher levels of inflammation after strenuous exercise. A longer rest period between training sessions may be required compared to A allele carriers. Time Stamped Show Notes: 0:41 – Jonny opens the show 1:07 – Jonny introduces CRP gene and its impact on aerobic trainability and recovery 2:33 – Jonny discusses how CRP impact inflammation and recovery from strenuous exercise 3:03 – Jonny gives suggestions on how a person can change their diet in relation to their CRP gene to aid in recovery 4:15 – Jonny explains how a polymorphism in the CRP gene affects recovery time 5:56 – Jonny explains why knowing about your CRP gene is important and how you can incorporate this knowledge to optimize your training. 7:33 – Jonny closes the show  Resources Mentioned: http://jap.physiology.org/content/jap/early/2006/12/14/japplphysiol.01028.2006.full.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2643022/ https://www.ncbi.nlm.nih.gov/pubmed/16546475 https://www.ncbi.nlm.nih.gov/pubmed/14652498

If you go to your doctor for a routine checkup, he or she will usually run very limited blood tests because of cost considerations and limited health insurance coverage. For anyone interested in optimal health, this is not much of a "checkup" at all since you're not checking much of anything. You could have low Vitamin D (almost certainly), elevated C-Reactive Protein (very likely) and a high A1C (very common) without knowing it. Today, we have the ability to go "rogue" and take our health into our own hands. Just like you can order a designer cocktail at your local bar, you can also order up your own blood tests and hire someone to help you review them. Rather than comparing your results to the national averages (which means a bunch of sick people), a qualified professional can help you analyze your results and help you work toward optimal health, not average health. On this week's Yoga Talk Show, you'll meet Dr. Stephen Lewis and Janet Lewis, founders of Doctor's Nutrition, an innovative company that advises you on blood work and helps you interpret the data. ------------ Listen & Learn: Why most doctors do extremely limited blood tests Why your results are usually green light or red light only, and the yellow range (warning!) is almost completely ignored How to go "rogue" and take your health into your own hands Why you should get an A1C test for a 3-month snapshot of your blood glucose management Why you should get your T3 (not just TSH) tested for thyroid health ABOUT OUR GUEST Dr. Stephen Lewis and Janet Lewis are the founders of Doctor's Nutrition. Doctor's Nutrition provides Evidence-Based Nutrition™ information, where you get information based on years of experience treating patients with natural compounds and verifying the results with pre and post lab tests. Located in Longview, Texas, Doctor's Nutrition offers medical lab services in or near your hometown without the need for expensive office visits and long waits. Nutritional Tip of the Week: Alkalized Water Links & References from the Show: Doctor's Nutrition Got Questions? Send me a voicemail here: Ask Lucas a Question Or write to us: podcast@yogabody.com  Like the Show? Leave us a Review on iTunes Thanks to our sponsor: Cork Yoga Block  This block was originally developed for the YOGABODY Fitness Studio Group because we needed an all-natural, eco-friendly, and non-slip prop to use in our public classes. Traditional, synthetic blocks are ugly, slip with sweat, and have an unpleasant hand-feel. Hence, Corky the Block was born! Yoga students use Corky the Block in dynamic Vinyasa Yoga practices, deep stretching Gravity Yoga sessions, and in advanced arm balancing and back-bending. A block is an essential yoga prop, and Corky the Block is a beautiful addition to your practice room. Learn More

If you're concerned about your cholesterol, or confused about what to do, this episode is for you. In this episode, I list the four key factors that control blood cholesterol levels and outline the simplest dietary or lifestyle changes we can make to have the biggest impact. This episode is brought to you by US Wellness Meats. Head to grasslandbeef.com and enter "Chris" at checkout to get 15% off your order as long as the final price is over $75 and you order fewer than 40 pounds of meat. You can use "Chris" to get the same discount twice. In this episode, you will find all of the following and more:  00:33 Cliff notes; 09:22 Targeting the low-hanging fruit; 11:50  The total-to-HDL-C ratio as a fingerprint of low LDL receptor activity; 13:20  Other markers such as particle size, particle count, and ApoB as fingerprints of low LDL receptor activity; 16:30  The four factors that control the LDL receptor; 18:50  Intracellular free cholesterol (effects of dietary fiber, cholestyramine, statins, and polyunsaturated fatty acids or PUFAs); 20:37  Thyroid hormone (effects of micornutrients, body fat, and carbohydrate intake); 23:50  Insulin (via PCSK9, effects of the fasting-feeding cycle and carbohydrate intake); 27:00  Inflammation (via PCSK9, effects of acute infection and chronic inflammation); 29:15  Practical approaches to maximizing LDL receptor activity; 29:22  Nutrient-dense whole food diets; 34:00  Thyroid disorder; 37:15   Adrenal stress, circadian stress, inflammatory stress; 39:05  Insulin resistance, body composition, and fatty liver disease; 42:00  Weight loss will improve insulin sensitivity, and for many a low-carb diet is a tool to achieve that, but in an insulin-sensitive person, carbohydrate stimulation of insulin has a powerful beneficial effect on LDL receptor activity; 46:20  Inflammation and PCSK9; 47:00  C-Reactive Protein levels, body composition, diet quality, and exercise; 49:25  Replacing fat with carbohydrate.  

Dai asks Spencer about the top three tests someone should consider getting. As Spencer is a genius in optimizing the human body, it was very hard for him to round it down to three. However, the top three listed in this show are probably the most important to help you detect inflammation and other bad things lurking in your body. Also, Spencer discusses some of the benefits of taking a DNA test, and why it’s good to know what cards you’ve been dealt, when it comes to your genetics.   Key Takeaways: [1:40] Spencer just came back from the islands of Hawaii! He shares some of his favorite slang words. [3:15] Dai has cologne where you can smell like a Canadian. [4:05] Dai has been working with Spencer on optimizing his health. [5:05] What three tests does Spencer recommend everybody get, as we head into the new year? [6:25] If you do feel resistance from your family doctor, then maybe it’s best to approach a naturopathic doctor for these tests. [8:15] Test number one: Get a C-Reactive Protein test done. [10:00] Test number two: A Homocysteine test. [12:35] Test number three: Your ferritin levels. [13:30] Spencer had a hard time picking the top three tests. You need like 20! [14:05] It’s important for women to check their ferritin levels. They are typically too low in iron. [14:40] When men have too much iron in their body, we rust! [17:10] Supplementation should be used to augment, not to replace. [19:05] What is the benefit of getting a DNA test? [20:55] Spencer always asks for a DNA test whenever a new client begins work with him. [23:10] You just don’t know what you don’t know. So take a leap and try out these tests.   Mentioned in This Episode: www.23andme.com/ www.ancestry.com/dna/   Connect With the Guys Here: Instagram: @22forlifepodcast #22forlife   Dai Website NetZeroGain   Adam Website   Spencer Website

Chronic inflammation is a precursor to a myriad of diseases and illness, and the foods and lifestyle choices we're making are largely at fault. Perhaps the biggest challenge with inflammation is you cannot see it, so it can be a "silent killer," wreaking havoc without you even aware of what's going on. This week's guest on the Yoga Talk Show hopes to change all that—and more. ------------ Listen & Learn: Why internal inflammation can contribute (or even cause) weight gain, aging and disease How a simple and cheap C-Reactive Protein test can tell you if this is a problem or not How some of the most common foods create a negative reaction inside our bodies Why arthritis, skin problems, and digestive issues might be linked to chronic inflammation There are two types of inflammation: chronic and short-term/acute How your microbiome health is crucial to your health Why you should avoid Non-Steroidal Anti-Inflammatory Drugs and antibiotics ABOUT OUR GUEST Kellyann Petrucci is a weight-loss and natural anti-aging transformation expert. She has a private practice in the Birmingham, Michigan area and is a concierge doctor for celebrities in New York City and Los Angeles. She is a board-certified naturopathic physician and a certified nutrition consultant. You might have seen her on The Doctors, Dr. Oz, and other television news programs. She is the driving force behind the website DrKellyann.com, and has authored six books for John Wiley & Sons. Nutritional Tip of the Week: Nut Milks Links & References from the Show: Find a Functional Doctor Dr. Kellyann's Site Got Questions? Write to us podcast@yogabody.com Thanks to our sponsor: Liquid Energy B If you're a vegetarian, live a high-stress lifestyle and/or are over 50 years of age, there's a very good chance you need to supplement with vitamin B12. B12 is one of the few vitamins that our body doesn't produce on its own. If you don't eat or supplement with B12, you will develop a deficiency that could lead to anemia, nerve damage, mood and mental health problems. Learn More

Susun Weed answers 90 minutes of herbal health questions followed by a 30 minute interview with Kaayla T. Daniel. KAAYLA T. DANIEL, PhD is known as The Naughty Nutritionist® because she “tells the truth that’s too hot to handle.” Kaayla is coauthor of the bestselling book Nourishing Broth: An Old-Fashioned Remedy for the Modern World (2014) and the author of The Whole Soy Story:The Dark Side of America's Favorite Health Food (2005). She received the Integrity in Science Award from the Weston A. Price Foundation in 2005, the Health Freedom Fighter Award from Freedom Law School in 2009, and the BadAss Award from the Paleo-Primal-Price Foundation in 2015.    this episode Q&A includes: • contact dermatitis- immune system protective- relieve symptoms with witch hazel, plantain leaf.. • elevated bilirubin and gassy- nourishing herbal infusions of violet leaf, chickweed, mullein, hibiscus- nourish digestion and liver with burdock, dandelion and yellow dock... • why use one herb at a time? to restore herbal medicine as people's medicine.. • anger and resentment and expressing emotion... • hemorrhoids- witch hazel, horse chestnut, stone root, restore elasticity to veins with stinging nettle infusion, foods to avoid and include... • slippery elm restores lining to small intestine... • cholesterol medicine makes muscles weak- your heart is a muscle...  

The post C-Reactive Protein (CRP) appeared first on NURSING.com.

In this VETgirl online veterinary CE podcast, we review C-reactive protein levels and whether or not they can be useful in managing your parvovirus cases.

In this VETgirl online veterinary CE podcast, we review C-reactive protein levels and whether or not they can be useful in managing your parvovirus cases.

Listen in as Dr. Mike provides the answers to a wealth of health and wellness questions.Here you'll find the answers to a wealth of health and wellness questions posed by Healthy Talk fans.Listen in because what you know helps ensure healthy choices you can live with. Today on Healthy Talk, you wanted to know:Are nutritional deficiencies to blame for being overweight? When you lack proper nutrition, your body may be showing you signs that you have a nutritional deficiency. These signs can be a number of things like brittle nails, bleeding gums, painful joints, hair loss, acne, dry skin, and many others. What about weight gain? A study from a children's hospital in Oakland, California conducted three eight-week trials involving the twice daily intake of nutrient bars for two months for 43 lean and overweight/obese adolescents. What researchers found was in the overweight/obese participants, there was a reduction in weight, weight circumference, diastolic blood pressure, heart rate, triglycerides, insulin resistance, C-Reactive Protein, and inflammation. Nutrition is extremely important; in fact, it's listed as one of the nine pillars of successful weight loss Dr. Mike wrote about. The rest of the pillars are: Restore insulin sensitivity Restore youthful hormone balance Control rate of carbohydrate absorption Increase physical activity Restore brain serotonin Restore resting energy expenditure rate Restore healthy adipocyte signaling Inhibit the lipase enzyme Eat to live a long and healthy life If you have a health question or concern, Dr. Mike encourages you to write him at askdrmikesmith@radiomd.com or call in, toll-free, to the LIVE radio show (1.844.305.7800) so he can provide you with support and helpful advice.

Nottingham Medico-Chirurgical Society presidential address. 1st October 2014.

The main ways our bodies age are through the mechanisms of drying up, burning up, turn to stone and we rust. Drying up is through dehydration and the deficiency of certain minerals. We burn up through the process of inflammation. We deposit Calcium into our arteries and we turn to stone. Lastly, we rust through oxidative stress.   Our bodies are inflamed for a number of reasons. We are exposed to so many environmental toxins that are aggravating inflammation in our body. We are eating more and more GMOs that cause inflammation and we're not eating foods that are naturally anti-inflammatory.   The healthy consumption of good oils helps reduce inflammation. You also need to eat a nutrient-dense diet and if you're not then you need to make sure you supplement your diet. Most people are deficient in Omega-3 Fatty Acids, which decrease inflammation. Triton Nutrition's Omega Prime Fish Oil contains 950mg per capsule. The fish oil is isolated from small cold-water fish under the polar ice cap, which are more pure than large fish, which usually absorb more toxins.   Omega 3-Fatty Acid consumption can reduce a number of inflammatory markers like hs-CRP (high-sensitivity C-Reactive Protein) as well as many other areas in the body. It inhibits a cascade of cytokines or eicosanoids that can aggravate inflammation.   The more we train, the more fatty acids are required. Those who are on certain medications that deplete their fatty acids or those with certain diseases such as diabetes also require more of these Omega-3 Fatty Acids. These Omega-3 Fatty Acids also lower triglycerides and help balance cholesterol levels.   Another product that reduces inflammation is the D3 Ultra Drops. Vitamin D deficiency is rampant here in the United States. The Harvard School of Public Health states that the best benefits of 25-hydroxy vitamin D is seen in the 70-90 ranges. Vitamin D below 50 is associated with insomnia. Low Vitamin D means that there is an increased production of inflammatory cytokines like IL-6, IL-17, TNF alpha. Vitamin D drops are relatively inexpensive. D3 Ultra Drops are 1200 units per drop and because it is miscellized it is highly absorbable.   Immune Boost Spray is an isolated form of colostrum produced from grass-fed, organically raised cows. PRPs are extracted from this colostrum. Dr. Andrew Keech's Peptide Immunotherapy book emphasizes the importance of colostrum and the proline-rich polypeptides (PRPs). These PRPs balance the process of inflammation and balance a healthy immune system. This is very important in times of autoimmune diseases like Lupus and Scleroderma.   For more information on the benefits of PRPs please see the article Viruses and the Advantages of PRPs.   by Robert Seik, PharmD

Today’s episode is with the always amazing Jimmy Moore, and we chat about his brand-spankin’ new book “Cholesterol Clarity: What the HDL is Wrong With My Numbers?” Congrats Jimmy – this book is one of a kind and finally sets the record straight on what has become an impossibly confusing subject! So if you’re shaking […]

This podcast highlights original research appearing in the April 2013 issue of Otolaryngology - Head and Neck Surgery, the official journal of the American Academy of Otolaryngology - Head and Neck Surgery (AAO-HNS) Foundation.  Editor in chief Richard Rosenfeld is joined in by lead author Annie Simpson and associate editor Jennifer Shin in discussing the role of cardiovascular disease markers in age-related hearing loss over time.

AIR DATE: November 1, 2012 at 7PM ETFEATURED EXPERT: FEATURED TOPIC: “Finding The Diet That's Right For You” If you've been listening to my podcasts or read my blog for any length of time, then you've obviously heard me talk about one of the basic philosophies that I think is an important part of living a healthy lifestyle. Here it is: "Find a diet plan that is right for you, follow that plan exactly as prescribed by the author and then keep doing that plan for the rest of your life making appropriate tweaks along the way to keep it working." But how do you go about figuring out what the "right" diet and lifestyle plan is for you? That's what we'll be exploring further in Episode 33 of "Ask The Low-Carb Experts" with a highly-qualified guest expert named  (listen to my March 2012 interview with Peter in ). TRY THESE DELICIOUS NEW PRE-MADE PALEO MEALSUSE COUPON CODE "LLVLC" FOR 10% OFF YOUR ORDERNOTICE OF DISCLOSURE: TRY THE WORLD'S FINEST CACAO BEAN LOW-CARB CHOCOLATEEnter "LLVLC" at checkout for 15% offNOTICE OF DISCLOSURE:  Here are some of the questions we addressed in this podcast: RENEE ASKS:I have been refining what I think is my perfect diet for about 3 years now. During that time my diet has drastically changed for the better. I eat a very strict Paleo autoimmune diet with no dairy, nuts or nightshades. This has worked very well for me and now I am experimenting with a few little things here and there to tweak my diet that help me go from feeling good to feeling great. I am wondering about the cross-reactivity of coffee with gluten. I have heard that this can be a problem for some people, but I dismissed it because I didn’t want to believe that it can be a problem for me. But now I’m thinking that it IS a problem for me because after quitting coffee I started losing weight with no other changes in my diet. And it's not just calories because I replaced the coffee with a coconut oil cocoa that would have equal calories since I made my coffee into a coconut oil latte anyway. I know that gut issues are the minority of manifestation of gluten intolerance, so this effortless weight loss might be showing some type of healing. I also heard that a study came out early this year confirming that a coffee/gluten cross reactivity is a significant problem. What are your thoughts on this issue? MICHAEL ASKS:I'd like to hear Peter address hypercaloric feeding on a ketogenic diet in combination with weight training. Is it possible for someone who is already basically lean and healthy to overeat and train his way up in size? What is the likely practical limit to size gain and performance in weightlifting with insulin levels being kept very low? MIKE ASKS:I have found success stabilizing my weight on a diet of 20-30g of carbs per day. However, I can't seem to lose those last stubborn pounds. I am a 5'8" male and currently weight 160 pounds with 19% body fat. My goal is to get down to 15% body fat. I started monitoring my ketones and after a month was able to lose another 4 pounds and 1% body fat, but it was very hard for me to maintain the high percentage of fat in my diet required to get my ketones high enough. Recently I started slow lifting and I really like that program. But when I increased my protein to aid muscle development I knocked myself out of ketosis and am right back to the 19% fat, 160-pound mark. I suspect a hormonal problem is contributing to the difficulties in losing but I’ve tested my testosterone twice and both times it’s near the high end of the "normal range." Recently my TSH also tested fine at 1.9, my Free T4 Direct was in the middle of the lab range at 1.32, and my TPOab was also in the middle at 12. My Free T3 was on the low end of the lab range at 2.2 (with the lowest reference range being 2.0). Given all of the above, are there variations I could try in my diet that could get me unstuck and help me reach my goal? MARYANN ASKS:I’m a 76-year old woman with the H63D gene for hemochromatosis and have high ferritin. My latest test was 436 and it goes up and down with an all-time high of 625. My doctors says that a phlebotomy is unnecessary unless it goes over 1000. I also have paroxysmal atrial fibrillation which I understand eating the Paleo way is the best for this. My A fib discussion board members say my ferritin is way too high now. What diet would you say would be the best for me? TINA ASKS:I am 42 years old and have been overweight since having children in my early 20s. I am 5'4" and weigh 199 pounds. My A1c was 5.8 when I check it a few months ago and my doctor advised me that I’m at risk for Type 2 diabetes and that I need to start exercising 30 minutes per day. I have been playing around with low-carb/Paleo and primal diets for the past few months but I can't decide which way to go. I have read tons of information and listen to many health podcasts like the ones from Jimmy Moore, Balanced Bites and Fat Burning Man. Where do I start? I crave sweets at least once a day and that continues to be my biggest downfall. How do I pick the diet that’s right for me? PALEOZETA FROM AUSTRALIA ASKS:I would like Dr. Attia to talk about intermittent fasting and…well, diarrhea. Sorry. About 10 minutes after I eat again following an intermittent fast, which works very well for me in conjunction with my ketogenic diet, I tend to have one or two bouts of diarrhea. I was reading that it could be our body expelling the toxins in it, but I’m not so sure about that. I’ve heard other people who do IF having this same issue. Do you have any insights about this? JAN ASKS:I'm a peri-menopausal woman, and I eat a low-carb, high-fat version of primal. My doctor is pushing statins on me strictly on the basis of my LDL-C which registered in at 142 using the Freidewald Equation. My HDL is 79 and my triglycerides are 71. Because of my insurer and financial situation, getting an NMR Lipoprofile test to measure my LDL-P is out of my reach to better assess my risk factors. I can't even get them to do a C-Reactive Protein test to assess whether there's inflammation. Is there any dietary tweak I can make to bring LDL-C lower without negatively impacting my excellent HDL and triglyceride readings? ERIC ASKS:It seems very timely that Dr. Attia will be on your podcast, Jimmy, as your latest Apo B results showing 238 and an LDL-P score of 3451 would appear to be quite alarming based on his recent “The Straight Dope On Cholesterol” series. Since Dr. Attia is a huge fan of ketogenic diets AND has a lot of knowledge about the importance of lipid markers, I would imagine he would be in a fantastic position to help clarify what is going on here. He seems to believe that the Apo B number is one of the most important markers of cardiovascular health. By the way, what is Dr. Attia’s Apo B number? JACK ASKS:Since cycling is a topic that is rarely addressed in Paleo/low-carb circles, does Peter have any tips for maximizing endurance athletic performance while on a ketogenic diet? Whenever I try to do cycling while in ketosis, I often feel fatigued and lose some of my power. Alternately, if I eat a lot of carbs and sugar-laden cycling food, I get stomachaches and feel bloated and grouchy most of the ride. Peter's blog has been the only thing I've ever seen talking about this topic and I’d appreciate hearing more from him about this. ROGER ASKS:Does a ketogenic diet repair or re-regulate an underactive thyroid? I’ve been on this diet for a year and a half now, but my hypothyroid symptoms still exist although I feel much better. My latest blood tests suggest I have low T3. I’m athletically built, never been overweight and exercise moderately. I’m wondering if Dr. Attia is a proponent of doing any thyroid supplementation in conjunction with a ketogenic diet as a beneficial approach to treating these hypothyroid symptoms? MICHELE ASKS:I heard you mention on your previous podcast with Jimmy that you use vegetables as a vehicle for consuming more fat. How important are vegetables in the diet if you’re eating a high-fat, low-carb diet? I always get confused because you hear how important it is to eat a lot of vegetables but I’m not particularly fond of a lot of them when trying to increase my ketones. TOM ASKS:We often hear the phrase used in the low-carb community that “there’s no dietary requirement for carbohydrate.” I’ve always assumed this comment was directed at the usual suspects like breads, cereals, pastas, legumes, etc. However, I have to ask, are vegetables really necessary to consume? In my case, I’m referring to non-starchy vegetables, such as kale, Brussels sprouts, cauliflower, and so forth. While vegetables contain vitamins, nutrients, fiber, and phytochemicals, I’ve read that cruciferous vegetables are also potentially goitrogenic. Cooking these vegetables for long periods of time supposedly helps to mitigate any deleterious effects, but the suggested cooking time is a minimum of 30 minutes. So what’s the scoop on veggies? DARREN ASKS:Over the past year and a half, I've been following a low-carb diet stopping short of nutritional ketosis. I'd put my daily carbohydrate input close to 100g out of a 2700- calorie diet. It has allowed me to accomplish and exceed the goals that I set out to do: - Lowered my Triglycerides from ~330 to

Fibrinogen is a target of autoimmune reactions in rheumatoid arthritis (RA). Fibrin(ogen) derivatives are involved in inflammatory processes and the generation of a stable fibrin network is necessary for sufficient inflammation control. As the density and stability of fibrin networks depend on complex interactions between factor XIIIA (F13A) and fibrinogen genotypes, the authors studied whether these genotypes were related to C-reactive protein (CRP) levels during acute-phase reactions.

In today's Wellness Minute Dr Fitness and the Fat Guy explained all about C-Reactive Protein. Listen right now to hear Dr Fitness' tips. Dr Fitness and the Fat Guy's Wellness Minutes improve your health in 3 minutes a day or less. iTunes Follow us on Twitter @FatGuy and @DrFitness6

In this episode I interview Dr Paul Ridker from Brigham and Women’s hospital about the JUPITER trial, a randomized trial of statins for prevention of cardiac events in people with elevated C-Reactive Protein who do not have hyperlipedemia.  Dr Ridker is hugely published as was on Time Magazine’s list of 100 Most Influential People.   We […]

Background: Type 2 diabetes mellitus is associated with increased cardiovascular risk. One laboratory marker for cardiovascular risk assessment is high-sensitivity C-reactive protein (hsCRP). Methods: This cross-sectional study attempted to analyze the association of hsCRP levels with insulin resistance, beta-cell dysfunction and macrovascular disease in 4270 non-insulin-treated patients with type 2 diabetes {[}2146 male, 2124 female; mean age +/- SD, 63.9 +/- 11.1 years; body mass index (BMI) 30.1 +/- 5.5 kg/m(2); disease duration 5.4 +/- 5.6 years; hemoglobin A(1c) (HbA(1c)) 6.8 +/- 1.3% ]. It consisted of a single morning visit with collection of a fasting blood sample. Observational parameters included several clinical scores and laboratory biomarkers. Results: Stratification into cardiovascular risk groups according to hsCRP levels revealed that 934 patients had low risk (hsCRP < 1 mg/L), 1369 patients had intermediate risk (hsCRP 1-3 mg/L), 1352 patients had high risk (hsCRP > 3-10 mg/ L), and 610 patients had unspecific hsCRP elevation ( > 10 mg/ L). Increased hsCRP levels were associated with other indicators of diabetes-related cardiovascular risk (homeostatic model assessment, intact proinsulin, insulin, BMI, beta-cell dysfunction, all p < 0.001), but showed no correlation with disease duration or glucose control. The majority of the patients were treated with diet (34.1%; hsCRP levels 2.85 +/- 2.39 mg/L) or metformin monotherapy (21.1%; 2.95 +/- 2.50 mg/L hsCRP). The highest hsCRP levels were observed in patients treated with sulfonylurea (17.0%; 3.00 +/- 2.43 mg/ L). Conclusions: Our results indicate that hsCRP may be used as a cardiovascular risk marker in patients with type 2 diabetes mellitus and should be evaluated in further prospective studies.

Mon, 1 Jan 1990 12:00:00 +0100 https://epub.ub.uni-muenchen.de/9772/1/relationship_between_angiotensinogen_alpha-1-protease_inhibitor_9772.pdf Jochum, Marianne; Kienapfel, G.; Kellermann, W.; Hilgenfeldt, U.

Sun, 1 Jan 1984 12:00:00 +0100 https://epub.ub.uni-muenchen.de/9223/1/9223.pdf Neumann, S.; Dittmer, H.; Duswald, Karl-Heimo; Jochum, Marianne

Can C-reactive protein levels predict respiratory decline in patients with COVID-19? Find out about this and more in today's PV Roundup podcast.