Autism Spectrum

Host: Paul Rokuskie Guest: David S. Mandell, ScD As prevalence rates for autism spectrum disorder (ASD) increase, so do economic costs. On average, medical expenditures for individuals with an ASD were 4 to 6 times greater than those without an ASD. Join Paul Rokuskie and his guest Dr. David Mandell, Associate Director of the Center for Autism Research at the Children’s Hospital of Philadelphia, as they dive into the economic impact of ASD.

Host: Paul Rokuskie Did you know that in just 10 years, the national prevalence rate for autism spectrum disorder (ASD) has nearly tripled, going from 1 in 166 to 1 in 59? Or that 2 percent of the US population under the age of 18 now carries a diagnosis of ASD? Join Paul Rokuskie as he speaks with Dr. Stuart Shapira, Associate Director for Science at CDC’s National Center on Birth Defects and Developmental Disabilities, about these and other findings from the 2018 study regarding prevalence rates for ASD.

Host: Paul Rokuskie As diagnostic information becomes more readily available, the importance of early diagnosis cannot be underestimated when it comes to helping those with autism spectrum disorder (ASD) and their families. Join Paul Rokuskie and his guest Dr. Stuart Shapira, Associate Director for Science at CDC’s National Center on Birth Defects and Developmental Disabilities, as they discuss the diagnosis criteria for ASD.

Host: Paul Rokuskie Scientists have been doing research into many areas of autism spectrum disorder in the hopes of explaining the doubling of its prevalence rate over the past decade. Both environmental risk factors and genetic components are areas of intense scrutiny for researchers seeking to understand the root causes of autism. Host Paul Rokuskie talks with Craig Newschaffer, Professor, Associate Dean for Research, and Director of the A.J. Drexel Autism Institute, about the risk factors for autism spectrum disorder that scientists are working to better define.

Host: Paul Rokuskie Over the past two decades, the world has seen a dramatic rise of individuals being diagnosed with autism spectrum disorder. For decades scientists and medical professionals have been researching various aspects of this disease to uncover genetic and environmental factors explaining this rapid increase in prevalence; however, discovering definitive clues to causality has proven elusive. Host Paul Rokuskie talks with Dr. Craig Newschaffer, Professor, Associate Dean for Research, and Director of the A.J. Drexel Autism Institute about the latest research findings into environmental factors affecting autism risk.

Host: Paul Rokuskie Researchers have been challenged for years by the simultaneous results of numerous studies into brain network connections in individuals with Autism Spectrum Disorder. Some results show strong connections, while others suggest the opposite. New research has helped bring some clarity to this ongoing paradox. Host Paul Rokuskie is joined by Dr. Benjamin Yerys, a child psychologist in the Center for Autism Research (CAR) at the Children’s Hospital of Philadelphia. They talk about how it’s possible to see conflicting results and, paradoxically, for both to be true.

Host: Paul Rokuskie Autism Spectrum Disorder affects communication skills as well as emotional & social development. Researchers have been studying the brain for decades to better understand how these developmental differences manifest as autism. Recent studies that measure rapid eye movement (REM) have been showing great promise in elucidating the origins and mechanisms of disease. Host Paul Rokusie sits down with Dr. John Foxe to talk about his study on rapid eye movement, its implications on disease pathogenesis, and new insights it can bring to future autism research.

Host: Paul Rokuskie As medical professionals gain better understandings of the etiologies, mechanisms, and progressions of autism spectrum disorder, they are looking for ways to standardize this diagnosis. This creates new needs to change the way autism is conceptualized clinically, from severity scales to behavioral impacts on quality of life. Host Paul Rokuskie welcomes Dr. Sven Bolte, Professor of Child and Adolescent Psychiatric Science and Director of the Center of Neurodevelopmental Disorders at Karolinska Institute in Stockholm, Sweden. The two discuss the complex process for building new diagnostic criteria for autism spectrum disorder.

Host: Paul Rokuskie New research is vital toward better understanding the complexities of autism spectrum disorder. Joining host Paul Rokuskie to discuss the latest research projects striving to identify the underlying causes as well as effective treatments for autism is Dr. Robert Schultz, Director of the Center for Autism Research at Children’s Hospital of Philadelphia.

Host: Paul Rokuskie Recent studies have uncovered sex differences in both the neurobiology and phenotypical presentations of autism. These emerging understandings for how autism manifests uniquely in girls vs boys may radically change the way autism spectrum disorder is clinically perceived, improving diagnostic sensitivity and personalizing therapies. Joining host Paul Rokuskie to discuss this line of research developments in autism spectrum disorder is Dr. Kaustubh Supekar, research scientist in the Department of Psychiatry at Stanford University School of Medicine.

Host: Paul Rokuskie Host Paul Rokuski welcomes Dr. Sally Rogers, Professor of Psychiatry & Behavioral Sciences and Director of Training and Mentoring at the MIND Institute of the University of California-Davis. Dr. Rogers specializes in conducting developmental and treatment research into autism and other developmental disorders. She is currently focused on developing and improving treatments for early autism using a treatment model that she developed in collaboration with Geraldine Dawson, the Early Start Denver Model.

Host: Paul Rokuskie Andy Bondy, PhD, Co-Founder and President of Pyramid Educational Consultants, Inc. join host Paul Rokuski for an in-depth discussion on the Picture Exchange Communication System (PECS), which allows children with autism who have little or no communication abilities a novel means of communicating non-verbally.

Host: Paul Rokuskie Autism Spectrum Disorder has had some profound effects on our global culture over the past few years. As greater understandings of this neurological disorder are communicated by scientists, physicians, advocacy groups, educational professionals and parents, public awareness shifts and societies reshape how autism is ultimately perceived. Paul Rokuskie welcomes Richard Grinker, PhD, Professor and Chair of Anthropology, and Director of the Institute for Ethnographic Research, at the George Washington University. Their discussion centers on how cultures are affecting the way autism is understood, evaluated, and even diagnosed across the world.

Host: Paul Rokuskie Social and emotional skills come fairly easily for neurotypical individuals. But for those with a diagnosis of Autism Spectrum Disorder (ASD), these may be some of the most challenging skills to learn. Thankfully there is a lot of experience among educators using techniques to help individuals with ASD become more social. Join host Paul Rokuskie as he welcomes speech/language pathologist Jill Kuzma to discuss therapeutic approaches for social cognitive deficits in children with ASD.

Host: Paul Rokuskie When Derek Volk's oldest child, Dylan, was two years old, his wife suggested, "Something is not quite right with Dylan." They struggled for the next several years as they were bounced from one diagnostician to another, each offering a unique perspective on Dylan's challenging behaviors. Finally, at eight years old, Dylan was diagnosed with Asperger's Syndrome and the Volk family was able to start making sense of Dylan's differences. In Chasing the Rabbit, authors Derek and Dylan Volk share their respective experiences coping with the challenges of autism in the household and the healthcare system.

Host: Paul Rokuskie Autism spectrum disorder has been around for centuries, but the modern terminology of how it is defined only started in 1943 by Dr. Leo Kanner of Johns Hopkins Hospital. Since then, the definition of autism has changed many times, refined into today’s current understanding of this mental disorder. But one point of constancy over this time frame has been the advocacy work of mothers and fathers to better understand the disease that impacts their children’s lives, helping educate communities around them in turn to foster greater compassion and awareness. In this episode of the Autism Spectrum, host Paul Rokuskie speaks with Eustacia Cutler, autism rights advocate and mother of Dr. Temple Grandin, who is often referred to as the first person officially diagnosed with autism in the United States.

Host: Paul Rokuskie Joint attention, one of the defining characteristics of social interactions that becomes impaired in children with autism, is a developmental milestone of great importance to researchers and clinicians alike. With early detection of autism spectrum disorder, children can receive better treatments to gain more exposure and training for critical social processes. But is it possible for early detection of joint attention deficits, even in infancy, to one day serve as diagnostic markers for the disease? Joining host Paul Rokuskie to discuss the state of research and awareness on this developmental milestone for children with autism are Dr. Daniel Messinger, Developmental Psychologist and Professor of Psychology, Pediatrics, and Engineering at the University of Miami, and Devon Gangi, PhD candidate in the Department of Psychology, also at the University of Miami.

Host: Paul Rokuskie Autism is not just a child matter. As the prevelance rates of autism continue to rise, so do the numbers of patients entering adulthood. What are the special challenges faced by these patients, their families, and the clinicians who treat and counsel them both respectively? And how can updated therapeutic approaches help change the life trajectories for adults with autism? Host Paul Rokuskie welcomes Dr. Marsha Mailick, Interim Vice Chancellor for Research and Graduate Education at the University of Wisconsin in Madison, Wisconsin. Her research on autism in adults has brought new awareness and understanding to the special needs of this patient population.

Host: Paul Rokuskie Associations between autism and gastrointestinal health are being actively investigated in medical research. Two major projects, each spanning three years, are focusing in particular on intestinal bacteria, ie the microbiome, and constipation, respectively. Leading the charge on these investigations are Drs. Pat Levitt and James Versalovic. Dr. Levitt is Chair of Developmental Neurogenetics at Children's Hospital - Los Angeles (CHLA), while Dr. Versalovic is Chief of the Department of Pathology at Texas Children's Hospital. Their work seeks to better understand how the human microbiome impacts neural health and development, and how refined treatments aimed at changing this potential "gut/brain axis" may aid therapies for autism and other neurodevelopmental disorders. The funding for the research project that Dr. Pat Levitt and Dr. James Versalovic are conducting is awarded by a grant from Autism Speaks.

Host: Paul Rokuskie Autism Spectrum Disorder (ASD) is a significant public health issue, affecting over 1% of all American children under the age of 18. One organization, Autism Speaks, is accelerating the care of these individuals and their families to the next level through their Autism Treatment Network, which creates collaborations that bridge multiple discplines across the United States. Joining host Paul Rokuskie to elaborate on this initiative is Dr. Dan Coury, Professor of Pediatrics and Psychiatry at Ohio State University and Medical Director of the Autism Treatment Network.

Host: Paul Rokuskie For some time, serotonin and vitamin D have been proposed to play a role in autism, but until recently no causal mechanism has ever been established. Autism researchers Dr. Bruce Ames and Dr. Rhonda Patrick of Children's Hospital Oakland Research Institute (CHORI) join host Paul Rokuskie to discuss their study on the demonstrated impact of Vitamin D on social behavior associated with Autism Spectrum Disorder (ASD). Their research implicates vitamin D as an activator of serotonin, oxytocin, and vasopressin, three brain hormones that affect social behavior related to autism.

Host: Paul Rokuskie In recent years, the national prevalence rate for Autism Spectrum Disorder rose dramatically from 1 in 166 to 1 in 88. This change creates major societal, medical, and economic impacts, leading to questions of how and why the number of autism diagnoses in this country has risen so sharply. Joining host Paul Rokuskie to talk about this development is Dr. David Mandell, associate director for the Center for Autism Research and the Children's Hospital of Philadelphia, and John Baio, epidemiologist and priniciple investigator for the Autism and Developmental Disabilities Monitoring Network at the Centers For Disease Control and Prevention.

Host: Paul Rokuskie It has been over 10 years since the Diagnostic Statistical Manual of Mental Disorders, or DSM, has been updated and released in its fifth edition. There has been much anticipation and controversy over the many changes that have been incorporated, and among the most carefully scrutinized are those pertaining to autism spectrum disorder. Joining host Paul Rokuskie to discuss important DSM-V updates in the diagnosis and classification of autism are Dr. David Kupfer, Chair of the DSM-V Taskforce, and Dr. Catherine Lord of the Neurodevelopmental Disorders Workgroup.

Host: Paul Rokuskie For children with autism, negative health care experiences early on can deter them from seeking further medical care later in life, which can lead to significant cognitive and social impairments in adulthood. Creating a positive atmosphere in this environment therefore becomes an important responsibility for health professionals, but how can physicians and healthcare executives ensure that their medical practices or larger organizations are "autism-friendly?" Joining host Paul Rokuskie to discuss evidence-based approaches for effective interactions with autistic patients and their families is Dr. Judith Miller, a clinical psychologist and Clinical Training Director for the Center for Autism Research at the Children's Hospital of Philadelphia (CHOP).

Host: Paul Rokuskie Applied Behavioral Analysis (ABA) is considered a safe and effective treatment approach for children with Autism Spectrum Disorder, but it is often misconceived by parents and teaching professionals in school settings. Joining host Paul Rokuskie to discuss research behind ABA techniques for increasing positive, useful behaviors and reducing those that may cause harm or interfere with learning is Dr. Gina Green, Executive Director at the Association of Professional Behavioral Analysis.

Host: Paul Rokuskie Autism Spectrum Disorders have major impacts on three important building blocks of an individual's social skills: interactions, communications, and interests. Joining host Paul Rokuskie to discuss methods that clinicians can use to address socialization challenges with autistic patients is Carol Gray, Director of The Gray Center for Social Learning and Understanding in Grandville, Michigan.

Host: Paul Rokuskie Host Paul Rokuskie is joined by Drs. Declan Murphy and Will Spooren. Dr. Murphy is Professor of Psychiatry and Brain Maturation at Kings College, London, and Dr. Spooren is Group Leader of Behavioral Pharmacology at Roche Pharmaceuticals. Their topic for discussion is the large academic and industrial consortium known as European Autism Interventions, or EU-AIMS, which serves as a collaborative network bridging experts in autism across the spectrum of pharmacologic research and development.

Host: Paul Rokuskie Autism Spectrum Disorder is one of the greatest medical and social challenges facing not only the United States, but the entire world. As the medical community focuses resources on finding the causal factors for autism and delivering viable treatment options for patients, key specialists in translational neurobiology research are leading the charge. Dr. Robert Ring, Vice President and Head of Translational Research for Autism Speaks, the world's leading autism science and advocacy organization, speaks with host Paul Rokuskie about current advances in understanding, diagnosis, and treatment for this disorder.

Host: Paul Rokuskie Host Paul Rokuskie is joined by Mercedes Ignasiak and Vanessa Vega, both parents of children with autism. Their conversation centers on the impact of this disease on entire families, how parents manage autism at home, and their roles as key contributors to the healthcare team.