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The U.S. House will hold a hearing on fraud in Minnesota's social service programs in early January and again in February. The Republican-led House Committee on Oversight and Government will hear from three GOP state legislators from Minnesota Jan. 7. The Initiative Foundation in central Minnesota is providing financial support to Somali American nonprofit organizations facing harassment and threats.This is an MPR News Evening update, hosted by Emily Reese. Theme music is by Gary Meister. Subscribe on Apple Podcasts, Spotify, YouTube or RSS.
In 2014, a military spouse and a priest—both avid bakers—wanted to create a fun, welcoming place that could help out transitioning veterans. They started Dog Tag Bakery, a Washington café that not only serves coffee and treats but also hosts a business incubator program. Over the last decade, the organization has assisted almost four hundred veterans and military spouses in their startup companies, creating employment—and high spirits—across the country. Hosts LTG (Ret.) Leslie C. Smith and SMA (Ret.) Dan Dailey sit down with Dog Tag's Director of Programs and Community Impact, Maureen Devine-Ahl, and Army spouse and entrepreneur, Erin Vandre, to discuss what lessons the bakery teaches its fellows, how it aided Erin in the launch of her business (also a bakery!), and what their favorite sweets are. Guests: Maureen Devine-Ahl, Director of Programs and Community Impact, Dog Tag Bakery Erin Vandre, Dog Tag Bakery Fellow and Founder, Bravory Bakehouse Has a member of the Army positively changed your life? Now is your chance to thank them publicly with a shoutout via our Hooah Hotline and have it possibly appear on an upcoming episode of AUSA's Army Matters podcast! AUSA's Army Matters podcast can also be heard on Wreaths Across America Radio on Monday at 8 pm Eastern. You can find Wreaths Across America Radio on the iHeart Radio app, the Audacy app, and the TuneIn app. Search the word Wreath. Donate: If you are interested in supporting AUSA's educational programs, such as this podcast, please visit www.ausa.org/donate. Feedback: How are we doing? Email us at podcast@ausa.org. Disclaimer: AUSA's Army Matters podcast primary purpose is to entertain. The podcast does not constitute advice or services. While guests are invited to listen, listeners please note that you are not being provided professional advice from the podcast or the guests. The views and opinions of our guests do not necessarily reflect the views of AUSA.
SUMMARY: - “Hurting people hurt people—but narcissists mean to. The higher up the spectrum, the more deliberate and sadistic it becomes.” - “A normal person can self-reflect and repair. A narcissist can't or won't—self-reflection feels like death to them.” - “You didn't cause this, and you can't fix it. It's not your fault.” - “As darkness rises, so does the glory of God. What the enemy meant for evil, God can turn for good.” - “If you move slowly and keep physical/emotional boundaries while dating, a narcissist will often disqualify himself.” Annette's 4-category spectrum - Category 1: “Normal” human flaws—can be selfish or insensitive at times, but can self-reflect, repent, repair, and grow. - Category 2: Emotionally immature; hurtful without calculated malice. Constant defensiveness, blame-shifting, meltdowns when confronted. Change is unlikely; aim is reducing chaos and managing wisely if you choose to stay. - Category 3: Calculated and conniving. Love-bombing, data-mining your hopes/fears to weaponize later. Public charm/private cruelty. Dangerous in church/community settings. You won't resolve this. - Category 4: Sociopathic/psychopathic traits. Amplified cruelty and real danger. Divorce triggers the “monster.” Requires safety planning, documentation, and expert help. Dating red flags and protection - Love-bombing: intense pursuit, “soulmate” language, over-the-top gestures, fast-moving timeline. - Boundary testing: pushes past your limits; discomfort rises quickly. - Inconsistencies and subtle cruelty: backhanded comments, smirks at tears or grief, delight in your pain. - How to protect: move slowly, keep physical/emotional boundaries early, listen to the Holy Spirit and your discomfort, look for patterns (not isolated incidents), and let time test character. If you stay (Category 2 dynamics) - Goal: not fixing him, but wisely reducing chaos and preserving your well-being and the household's stability. - Tactics: reframe requests in terms of what benefits him; avoid head-on confrontation; build your life outside the relationship (calling, ministry, education, friendships). - Support: grief the loss of the dream; get equipped; find a small, trusted peer group who truly understands narcissistic abuse. If you're considering leaving (especially 3–4) - Safety first: if there's a risk of harm, have a go-bag for you/kids/pets and get out. - Prepare: document everything; expect financial sabotage; avoid using the term “narcissist” in court unless there's a diagnosis. - Kids: courts may be vulnerable to “parental alienation” claims; consider a High-Conflict Divorce Coach to reduce legal costs and navigate strategy. - Church/community: narcissists often “borrow” your credibility and pre-poison relationships. Find a healthy church culture and rebuild wise support. Biblical considerations for divorce - Abuse, abandonment, adultery are valid biblical grounds. With minors, weigh carefully: safety, modeling for children, and the realities of family court. Healing and identity - Post-abuse, identity is almost always impacted. You can be 10 years out and still hear their voice in your head—self-abuse by proxy. - The path: clean up the past (lies, agreements, unresolved pain), rebuild identity in Christ, then step into power and authority with wisdom and boundaries. - Beauty must rise with pain: intentionally add joy, nature, creativity, and community to counterbalance suffering. Church and parenting insights - Teach kids the Word, discernment, and healthy vs. unhealthy relationship dynamics. Christlike love includes boundaries and walking away when necessary. Programs and resources Annette mentioned - Living Well While Staying: coaching for women who choose to remain in Category 2 marriages, focused on reducing chaos and rebuilding a meaningful life. - Cinderella No More Academy: membership community and tools for recovery and growth. - Cinderella Conversations: 4-session discovery series on identifying narcissistic dynamics, tactics, false guilt, and spiritual warfare. - Upcoming book: Cinderella No More: Becoming Ella (target 2026). She's seeking early readers for feedback. - For severe trauma/PTSD: consider a Christian therapist specializing in trauma; complement with coaches who understand narcissistic abuse. Interview for fit. One thing to remember - You didn't cause it, you can't fix it—and this isn't the end. With God, this can be the beginning of a new, stronger chapter. You get to write the next chapters with Him. PODCAST INTRO: My guest Annette Chesney is a Christian coach, speaker, and seasoned recovery professional who equips women healing from narcissistic abuse. Narcissistic dynamics can be hard to spot because they often look like ordinary relationship friction at first. Many people struggle to tell the difference between someone who is simply hurting and occasionally hurtful, and someone who persistently harms others without accountability. One useful way to think about it is as a spectrum: not everyone with difficult traits is a narcissist, and not every narcissistic person behaves the same way. Understanding this range can help you decide what you're seeing—and what to do next. But before you think that keeps you in the dark….Annette has created a spectrum that consists of 4 categories or types of narcissists including 10 different characteristics. What she shares is very interesting and from my experience very accurate. Annette's work is done both one-on-one and in groups. She talks primarily from a women's point of view with regard to narcissistic abuse but she did say men are subject to women narcs as well. Annette talks about common red flags and she says pay attention to patterns over time rather than isolated incidents; that wider view tells the truth. Annette even shares about how she coaches women who choose to stay in a challenging relationship…she teaches “management” strategies that focus less on changing the other person and more on stabilizing her client's environment, protecting her energy, and minimizing chaos. A few of the examples she gave were learning how to reframe requests so they're seen as mutually beneficial, limiting circular arguments, and building a strong support system outside the relationship. She even touches on the subject for when separation or divorce becomes necessary and minor children are involved. She alerted us to the fact that trauma symptoms, including anxiety and PTSD‑like responses, are not uncommon adding that qualified mental health support and targeted coaching can help you recover clarity and confidence. Even with the reality of living with the effects of narcissistic abuse…the dismantling of who you are, loss of confidence, identity, goals, dreams etc. , Annette says recovery is possible. Many people find that healing involves unpacking earlier hurts, challenging false beliefs, rebuilding identity, and learning durable skills: boundaries, self‑care, emotional regulation, and discernment. Getting connected with the right help will make all the difference and get you to what she calls…your Kingdom Zone of Impact where you're living with identity and purpose in Christ. Her parting words were for the listener to remember two things that are worth holding onto: you didn't cause someone else's narcissistic pattern, and you can't fix it for them. What you can do is prioritize safety, educate yourself/get informed, surround yourself with wise support, and invest in your own future. Whether you're staying, preparing to leave, or rebuilding afterward, the next chapters can be healthier—with Christ those next chapters are filled with restoration and redemption, they can bring clarity, strength identity and purpose… and they're yours to discover with the Lover of Your Soul, the One who never abuses you, never fails you, Jesus. Live Loved and Thrive! Sherrie Pilk Connect With Annette: LinkedIn: https://www.linkedin.com/in/annette-chesney/ Website: https://annettechesney.com/ Visit her website for more information on the programs and resources Annette mentioned: - Living Well While Staying: coaching for women who choose to remain in Category 2 marriages, focused on reducing chaos and rebuilding a meaningful life. - Cinderella No More Academy: membership community and tools for recovery and growth. - Cinderella Conversations: 4-session discovery series on identifying narcissistic dynamics, tactics, false guilt, and spiritual warfare. - Upcoming book: Cinderella No More: Becoming Ella (target 2026). She's seeking early readers for feedback. - For severe trauma/PTSD: consider a Christian therapist specializing in trauma; complement with coaches who understand narcissistic abuse. Interview for fit.
Today: A broadcast of the most beloved Hawaiian songs of 1949 as the popular series bids aloha to 1949. Original Radio Broadcast Da Read more ...
There's a point where labs, diet, and protocols stop explaining why symptoms linger and that's where this episode begins.Healing doesn't always stall because the body lacks the right nutrients or protocol. Sometimes it's because the brain and nervous system are still holding unresolved trauma. Dr. Louise Swartswalter explains how neurobiofeedback and trauma release work can influence regulation, resilience, and the body's ability to heal. So If you're open to exploring how brain health and trauma resolution might fit into a root-cause thyroid healing approach, this episode will give you a thoughtful place to start. Listen NowEpisode Timeline: 00:03 – Welcome and guest introduction02:07 – Dr. Louise's health journey07:28 – Healing motivation and purpose08:24 – Biofeedback vs neurobiofeedback10:00 – Energy medicine acceptance13:49 – Remote brain work explained16:38 – Trauma and chronic illness17:08 – Hidden and stored trauma19:31 – Mindset versus energy21:45 – Womb and early trauma22:46 – Rewiring the brain24:22 – Anxiety and thyroid symptoms27:32 – Live brain rewiring example31:44 – Clearing childhood trauma35:47 – Brain balance demonstration39:27 – Small trauma, big impact43:10 – How to work with Dr. Louise45:30 – Programs and final thoughtsAbout Dr. Louise Swartswalter:Dr. Louise Swartswalter is a naturopath, frequency medicine practitioner, transformational coach, speaker, and mentor serving women and men worldwide. She is the creator of the Brain Soul Success Academy and the B.R.A.I.N. System™, a multidimensional approach that works with the mind, body, soul, and energetic field to support lasting change.With over 30 years of experience, Dr. Louise blends naturopathy, NLP, kinesiology, trauma-release work, and energy-based modalities to help people improve brain function, reduce stress, and move past long-standing blocks. Connect with Dr. Louise Swartswalter: Website - https://louiseswartswalter.com/ Facebook - https://www.facebook.com/LouiseSwartswalter1/ Instagram - https://www.instagram.com/drlouiseswartswalter/ Youtube - https://www.youtube.com/c/LouiseSwartswalter Free resources for your thyroid healthGet your FREE Thyroid and Immune Health Restoration Action Points Checklist at SaveMyThyroidChecklist.comHigh-Quality Nutritional Supplements For Hyperthyroidism and Hashimoto' s Have you checked out my new ThyroSave supplement line? These high-quality supplements can benefit those with hyperthyroidism and Hashimoto's, and you can receive special offers, along with 10% off your first order, by signing up for emails and text messages when you visit ThyroSave.com. Do You Want Help Saving Your Thyroid?Get free access to hundreds of articles and blog posts: https://www.naturalendocrinesolutions.com/articles/all-other-articles Watch Dr. Eric's YouTube channel: https://www.youtube.com/c/NaturalThyroidDoctor/videos Join Dr. Eric's Graves' disease and Hashimoto's group: https://www.facebook.com/groups/saveyourthyroid Take the Thyroid Saving Score Quiz: https://quiz.savemythyroidquiz.com/sf/237dc308 Read all of Dr. Eric's published books: http://savemythyroid.com/thyroidbooks Work with Dr. Eric: https://savemythyroid.com/work-with-dr-eric/
Leave a message & include your contact or I won't know it's you.The New Year is soon! So let's dive in to being a Better You.Do you ever feel like you're stuck in life — spinning your wheels, starting over and over but never following through? Maybe you've tried to eat healthier, save money, be a better partner, or show up as the mom you want to be… but no matter how hard you try, you just can't seem to stick with it. That constant cycle of starting, failing, and feeling like you're not enough can leave you frustrated, sad, or even depressed.In this interactive episode of The Be a Better You Podcast, Allison K. Dagney takes you step by step through a powerful exercise to define what “being a better you” actually looks like — so you finally have clarity instead of vague goals that keep you stuck. You'll unpack the subconscious beliefs that sabotage your progress, discover the hidden trauma responses that make it harder to take action, and learn how to break free from these old patterns.By the end of this episode, you'll have a simple but clear roadmap for taking action, plus fresh motivation to believe you really can create a healthier, happier, more successful life.If you're tired of feeling like you'll never change, this episode will show you how to finally shift from hopeless and stuck to confident and in control.Support the showTo learn more about my Programs visit the websitewww.radiatenrise.com Email: Allison@radiatenrise.comFree 30 Min Root Cause Call Join Radiate and Rise Together - Survivor Healing Community for Women To send a DM, visit Allison's profiles on Instagram and Facebookhttps://www.instagram.com/allisonkdagney/https://www.facebook.com/allisonkdagney/*Formerly (The Emotional Abuse Recovery Podcast)
https://teachhoops.com/ Think youth sports isn't big business? Think again. Are you charging too much…or not enough? Many coaches assume youth basketball is all about drills, but few consider how pricing and community needs impact participation. In this episode, Bill Flitter and data expert Mal Mizen bust myths about spend, accessibility, and what really keeps kids in the game. Are you tuned in to your players' real barriers? Discover: How pricing can make or break your program's growth Ways to understand your community's spending habits Tips to keep basketball accessible for every kid Even more practical data insights await! To access the research mentioned in the podcast, go here: https://open.substack.com/pub/youthsportshq/p/youth-sports-tam-and-spending-report Learn more about your ad choices. Visit podcastchoices.com/adchoices
Can you imagine if the mob still ran Las Vegas today? Co-host Sarah Lohman talks with Geoff Schumacher, VP of Exhibits and Programs at The Mob Museum, about what life used to be like in our city — and why nostalgia for this era is so prevalent today. Also, heads up: We've got an extended cut in the members-only feed that goes into the origins of the Vegas mob and all the businesses they ran in town. Get your members-only feed by becoming a City Cast Las Vegas Neighbor. Learn more about the sponsors of this December 30th episode: Simply Eloped Want to get in touch? Follow us @CityCastVegas on Instagram, or email us at lasvegas@citycast.fm. You can also call or text us at 702-514-0719. For more Las Vegas news, make sure to sign up for our morning newsletter, Hey Las Vegas. Learn more about becoming a City Cast Las Vegas Neighbor at membership.citycast.fm. Looking to advertise on City Cast Las Vegas? Check out our options for podcast and newsletter ads at citycast.fm/advertise.
Vulnerable populations suffer in a variety of ways. One way is having a lack of access to financial services - either lacking transportation, or awareness that services exist. Joining Chris to discuss a new mobile tax service provided by the United Way of South Central Michigan, is their Senior Director of Community Impact & Programs, Bethany Stutzman and CEDAM Member, Quill Stellaris!
Justin Barclay filling in for Glenn. Hundreds of millions of dollars laundered in Minnesota in one of the biggest fraud scandals in history. Gov. Walz defends Somali community. Alirezah Jafarzadeh, Deputy Director of the U.S. office of the National Council of Resistance of Iran, joins to discuss Iran declaring 'full-scale war' on the U.S., Israel and Europe. Scott Singer, Mayor of Boca Raton, joins to discuss his run for Congress and the important issues facing America today. Massive fraud uncovered in Ohio by Somali Immigrants. Mike Lindell joins to discuss his run for Governor of Minnesota and recent fraud uncovered. Gavin Newsom releases video wishing everyone 'Happy Kwanzaa'. Learn more about your ad choices. Visit megaphone.fm/adchoices
Post-traumatic stress disorder is common among veterans, with 10% of men and nearly 20% of women reporting having symptoms at some point in their lives. But could exposure to more arts programming be the needed prescription for those who have served our country? Stephanie Sy reports for our look at the intersection of art and health, part of our arts and culture series, CANVAS. PBS News is supported by - https://www.pbs.org/newshour/about/funders. Hosted on Acast. See acast.com/privacy
Post-traumatic stress disorder is common among veterans, with 10% of men and nearly 20% of women reporting having symptoms at some point in their lives. But could exposure to more arts programming be the needed prescription for those who have served our country? Stephanie Sy reports for our look at the intersection of art and health, part of our arts and culture series, CANVAS. PBS News is supported by - https://www.pbs.org/newshour/about/funders. Hosted on Acast. See acast.com/privacy
Text us your thoughts on the episode or the show!In this episode of OpsCast, hosted by Michael Hartmann and powered by MarketingOps.com, Michael is joined by co-host Mike Rizzo for a candid conversation about why most Account-Based Marketing programs fail and how teams can fix them.Their guest is Mason Cosby, Founder and CEO of Scrappy ABM, a leading voice challenging conventional ABM thinking. Mason shares why roughly 80 percent of ABM programs launched in recent years have not delivered results, why most companies already have what they need to succeed, and how to build a scalable ABM program without buying new technology.The discussion cuts through hype to focus on fundamentals, targeting discipline, organizational alignment, and realistic execution. Mason breaks down his practical framework for identifying best customers, avoiding common ABM pitfalls, and rebuilding programs that are stuck in the messy middle.In this episode, you will learn:Why most ABM programs fail before they ever have a chance to workWhat the 70 to 75 percent of existing tools and data most companies already have actually looks likeHow to identify the best customers using simple, objective criteriaWhere ABM programs break down when alignment is missingHow to measure ABM success without overcomplicating the modelWhat role does AI really play in modern ABM effortsThis episode is ideal for Marketing Ops, RevOps, demand generation, and GTM leaders who want a practical, realistic approach to ABM that works at any stage without unnecessary complexity.Episode Brought to You By MO Pros The #1 Community for Marketing Operations ProfessionalsSupport the show
About our guest:Danielle Palmer, CNMT was born and raised in Northern California and diagnosed with Juvenile Rheumatoid Arthritis at the age of two. After leaving home to attend California State University, Fullerton, Danielle competed as an NCAA Division I Fencer and was highly involved in the Theatre and Dance Department. Her lifelong passion for helping others initially led her to consider Physical Therapy. However, years of injuries and unresolved pain from JRA left her disillusioned with conventional Western Medicine—until she discovered SCENAR and Frequency Medicine.Determined to master her craft, Danielle pursued advanced training with SCENAR Health USA and later traveled multiple times to London to study with the Revenko SCENAR Academy of Russia, the English school of the “Father of SCENAR,” Professor of Neurology Dr. Alexander Revenko. She has achieved Master Class certifications in Advanced Spinal Disorders, Immune Support, Joint Flexibility, and the New Advancements of SCENAR Therapy, making her one of the most highly trained SCENAR practitioners in the United States. The Revenko Academy of Russia recognizes her as one of its top international practitioners and mentors.Her mission remains clear: to empower others to harness the body's innate healing potential through bioelectric and frequency-based therapies.Danielle's Links:Website: https://www.frequencytherapistofficial.com/ Instagram: https://www.instagram.com/thefrequencytherapist/Programs: https://www.frequencytherapistofficial.com/programs Stephanie's links:Tiktok: https://www.tiktok.com/@drstephpeacockInstgram: https://www.instagram.com/drstephpeacock/Website: https://stephaniepeacock.com/ Subscribe to my newsletter: https://stephanies-newsletter-c410d1.beehiiv.com/subscribe
The Gavel Podcast is the official podcast of Sigma Nu Fraternity, Inc., and is dedicated to keeping you updated on the operations of the Legion of Honor and connecting you to stories from our brotherhood. To find out more from the Fraternity, you can always check out our website at www.sigmanu.org. Also consider following us on: Facebook | Instagram | LinkedIn | YouTube | FlickrHave feedback or a question about this episode? Want to submit an idea for a future topic you'd like to see covered? Contact the Gavel Podcast team at news@sigmanu.org. Hosts for this EpisodeChristopher Brenton - Beta Tau Chapter (North Carolina State) Alumnus and Sigma Nu Fraternity's Director of CommunicationsGuest for this EpisodeDominic Frattura - Zeta Upsilon Chapter (Arizona State) Alumnus and Director of Advocacy for the North American Interfraternity ConferenceEpisode ReferencesNorth American Interfraternity Conference - The North American Interfraternity Conference (NIC) is a trade association representing 58 inter/national men's fraternities.ENGAGE - ENGAGE is the go-to network for sorority and fraternity campus leaders and alumni who are passionate about advocating for the fraternal movement. Through various programs and initiatives, ENGAGE supports and promotes participation in government, public policy, and on-campus student government opportunities. Programs and initiatives include FGRC Capitol Hill Visits, ENGAGE Ambassadors, Student Government Grants, and the First Amendment Institute. General ResourcesRegistration for the Sigma Nu Institute - The Sigma Nu Institute is designed to assist with the officer transition process and the learning curve that accompanies taking on new positions of chapter leadership. Both newly elected and mid-term officers will benefit from the program through increased exposure to and education on the knowledge and skills required for their roles. Attendees will also learn about key Fraternity programs, policies, and procedures.Prospective Member Referral - Do you know a young man who would be an ideal candidate for Sigma Nu? Please submit a membership referral.Employment and Staff Hiring Resources - If you are interested in learning more about working for the Fraternity as a consultant. Please visit the employment webpage for resources and access to the position application. The application deadlines are October 15 and March 1. Applications are accepted on a rolling basis. Contact Scott Smith at scott.smith@sigmanu.org for more information.Become a Volunteer - Learn more and take the next steps to become a volunteer for the Fraternity.Establish or Serve an Alumni Chapter - Learn more about how to help establish and maintain an Alumni Chapter.Organize an Alumni Club - Learn more about how to become engaged with or set up an Alumni Club.Donate to the Sigma Nu Educational Foundation - Give a gift to help advance the Fraternity's honorable Mission.
If you've ever said to yourself, “Porn ruined my life” — but still find yourself going back to it — this episode is for you.For years, I believed quitting porn was about discipline, willpower, and avoiding temptation. But what I eventually discovered — both in my own recovery and in my work with men — is that porn addiction isn't just about pleasure. It's about attachment. And often, it's an attachment not only to pleasure… but to pain.In this episode, I explore a side of porn addiction recovery that almost no one talks about: grieving your porn addiction.Whether you realize it or not, porn has likely been a relationship in your life — a companion you turned to for comfort, escape, connection, control, or relief from emotional pain. And when you try to quit porn without understanding what it's been doing for you emotionally, your nervous system resists. That's why porn cravings feel so powerful. That's why relapse feels inevitable. And that's why so many men stay stuck in shame-based cycles.We dive deep into the psychology and neuroscience of porn addiction, including:Why your brain can become attached to both pleasure and punishmentHow early emotional wounds and trauma shape porn useWhy your sexual fantasies aren't random — and what they reveal about unmet emotional needsHow attachment to familiarity (even painful familiarity) keeps porn addiction aliveWhy willpower alone fails — and what actually leads to lasting recoveryI also walk you through a step-by-step emotional process for grieving porn — not shaming it, not white-knuckling it, but understanding it — so you can finally leave it behind without fear, self-hatred, or constant relapse.If you're tired of fighting yourself… If you feel disconnected from your body, your relationships, or your purpose… If quitting porn feels harder than it “should”…You're not broken. And you're not weak.You may simply be trying to walk away from something your nervous system believes it still needs — without honoring the grief underneath it.This episode will help you understand:What porn has been symbolically trying to give youWhat you're afraid of losing if you let it goAnd how to meet those needs in ways that actually align with who you areThis is porn addiction recovery rooted in psychology, emotional healing, and compassion — not fear or control.Listen in, and let's talk about the real path to freedom.Link to Blog Article for this episodeIf you're looking for deeper support and real connection in recovery, I'm opening the No More Desire Brotherhood on January 15th. The pre-launch is open right now, and when you join you'll get free lifetime access to my 4 Pillars of Recovery mini-course, plus exclusive pre-launch bonuses. You can learn more and join here: https://www.nomoredesire.com/prelaunchGrab my Free eBook and Free Workshop for more strategies to overcome porn addiction, rewire your brain, and rebuild your life.Support the showNo More Desire
Anyone can catch lightning in a bottle once. Kelly Christensen is proving that he can repeat success over and over, as he just won back-to-back national high school cross country titles at NXN, and is clearly on the Mount Rushmore of high school distance coaches. The Niwot boys cross country team just won a second consecutive national title on December 6 in Oregon. Their 61 points set a record for the best team score ever recorded at Nike Cross Nationals, which began in 2004.The boys were led by Quinn Sullivan (5th with a time of 15:09), Hunter Robbie (6th), Ryder Keeton (33rd), Jude Ritzenhein (40th), and Gabe Marshall (60th). The girls team came in second. Heading into this season, Coach Kelly had guided the Cougars to 12 total state championships. You can add to that number after another dominating season this year. He recently was recognized on a national level by being named MileSplit's Coach of the Month in November 2025 for his program's continued excellence.If you want to understand how elite programs stay elite, Kelly Christensen is back on the Running Effect. No fluff or preamble: he's opening up about another dominant and historic season for the Niwot Cougars. Tap into the Coach Kelly Christensen Strand Special.If you enjoy the podcast, please consider following us on Spotify and Apple Podcasts and giving us a five-star review! I would also appreciate it if you share it with your friend who you think will benefit from it. Comment the word “PODCAST” below and I'll DM you a link to listen. If this episode blesses you, please share it with a friend!S H O W N O T E S-The Run Down By The Running Effect (our new newsletter!): https://tinyurl.com/mr36s9rs-Our Website: https://therunningeffect.run -THE PODCAST ON YOUTUBE: https://www.youtube.com/channel/UClLcLIDAqmJBTHeyWJx_wFQ-My Instagram: https://www.instagram.com/therunningeffect/?hl=en-Take our podcast survey: https://tinyurl.com/3ua62ffz
Podcast: Industrial Cybersecurity InsiderEpisode: The Hidden Reason Most Manufacturing Cybersecurity Programs FailPub date: 2025-12-23Get Podcast Transcript →powered by Listen411 - fast audio-to-text and summarizationDino sits down with cybersecurity expert Wil Klusovsky to discuss the massive gap between IT security practices and OT reality. With 26 years of experience, Wil shares his unconventional journey into operational technology and reveals why most security tools end up as shelfware on plant floors.They dive deep into the communication breakdown between CISOs and plant operations, the critical role of system integrators and OEMs that IT leaders often ignore, and why the "air gap" myth continues to put manufacturing facilities at risk.Wil breaks down his framework for speaking to boards in language they understand, emphasizing business impact over technical jargon. The conversation covers everything from the challenges of MFA implementation in OT environments to why patching isn't always the answer. They discuss how organizations can build effective OT security programs by making cybersecurity everyone's responsibility - not just IT's problem.Chapters:(00:00:00) - Opening: The $50K Security Investment That Nobody Uses(00:01:00) - Will's Unconventional Journey Into OT Cybersecurity(00:03:45) - The Communication Gap Between IT and OT Teams(00:07:15) - Why Asset Visibility Tools Miss 135% of Your Equipment(00:10:30) - Speaking Board Language: Revenue Loss vs. Technical Jargon(00:13:25) - The Missing Third Leg: System Integrators and OEMs(00:17:30) - Making Cybersecurity Everyone's Job, Not Just IT's Problem(00:21:15) - Why Patching Isn't Always the Answer in OT Environments(00:25:45) - The Reality Check: Physical Security in Manufacturing Plants(00:28:30) - Building a Cybersecurity Program as a Journey, Not a DestinationLinks And Resources:Wil Online LinktreeWil Klusovsky on LinkedInWant to Sponsor an episode or be a Guest? Reach out here.Industrial Cybersecurity Insider on LinkedInCybersecurity & Digital Safety on LinkedInBW Design Group CybersecurityDino Busalachi on LinkedInCraig Duckworth on LinkedInThanks so much for joining us this week. Want to subscribe to Industrial Cybersecurity Insider? Have some feedback you'd like to share? Connect with us on Spotify, Apple Podcasts, and YouTube to leave us a review!The podcast and artwork embedded on this page are from Industrial Cybersecurity Insider, which is the property of its owner and not affiliated with or endorsed by Listen Notes, Inc.
The international Fresh Produce Association is a trade group with the mission of helping businesses at every step along our food supply chain.
Send us a textKarl W. Kuhnert, Ph.D. is Professor of the Practice of Organization and Management in the Goizueta Business School at Emory University. Karl's research focuses on how leaders cognitively, interpersonally, and emotionally develop over the life course. Karl has published over 80 peer-reviewed articles, 13 book chapters and made over 100 conference presentations, and served on numerous editorial and review panels. He teaches industrial and organizational psychology, leadership, organizational change, and professional ethics. Karl has won numerous awards for teaching and research. Karl also regularly teaches leadership development in the Executive Ed. Programs at Emory, UCLA, HEC Paris, and UGA. He has served as a consultant with many large and small corporations, non-profit and government organizations including, United Parcel Service, The U.S. Dept. of Treasury, Siemens, The Jet Propulsion Lab, and Cox Automotive.A Few Quotes From This Episode“Every time I have done this, it has freed up experts to do the work they actually want to do.”“Tacit knowledge is lived wisdom—it's what makes an expert an expert.”“AI is a tool, it is not truth.”“We need to ask how judgments are made, not just whether AI can render them.”Resources Mentioned in This EpisodeBook: Personal Knowledge by Michael PolanyiBook: The MAP: A Practical Guide to Leadership Development by Keith Eigel & Karl KuhnertArticle: Training Innovative AI to Provide Expert Guidance on Prescription Medications by KuhnertArticle: Teaching Leadership: Where Theory Bridges Practice by KuhnertAbout The International Leadership Association (ILA)The ILA was created in 1999 to bring together professionals interested in studying, practicing, and teaching leadership. About Scott J. AllenWebsiteWeekly Newsletter: Practical Wisdom for LeadersMy Approach to HostingThe views of my guests do not constitute "truth." Nor do they reflect my personal views in some instances. However, they are views to consider, and I hope they help you clarify your perspective. ♻️ Please share with others and follow/subscribe to the podcast!⭐️ Please leave a review on Apple, Spotify, or your platform of choice.➡️ Follow me on LinkedIn for more on leadership, communication, and tech.
Join us for an engaging conversation with Dr. Dustin Allen, Clinical Assistant Professor and Director of Programs in Human Physiology at Boston University. In this episode, Dr. Allen shares their experience with thermoregulation, virtual reality, and the power of mentorship in career and education.
Farmer Bridge Assistance Program Used Failed Wheat Crop for Cattle Understanding More About Bull Fertility 00:01:05 – Farmer Bridge Assistance Program: David Schemm, state executive director for the Kansas Farm Service Agency, kicks off the show as he highlights what he learned in Washington D.C. and the new Farmer Bridge Assistance Program. Farmers.gov 00:12:05 – Used Failed Wheat Crop for Cattle: Continuing the show is grad student in K-State's Animal Sciences and Industry, Adam King, discussing how producers can use a failed wheat crop for cattle rations. adamking@ksu.edu eabriggs@ksu.edu 00:23:05 – Understanding More About Bull Fertility: Part of the Beef Cattle Institute's Cattle Chat podcast with Brad White, Bob Larson, Todd Gunderson and Jason Warner concludes today's show as they converse about bull fertility. BCI Cattle Chat Podcast Bovine Science with BCI Podcast Email BCI at bci@ksu.edu Send comments, questions or requests for copies of past programs to ksrenews@ksu.edu. Agriculture Today is a daily program featuring Kansas State University agricultural specialists and other experts examining ag issues facing Kansas and the nation. It is hosted by Shelby Varner and distributed to radio stations throughout Kansas and as a daily podcast. K‑State Extension is a short name for the Kansas State University Agricultural Experiment Service, a program designed to generate and distribute useful knowledge for the well‑being of Kansans. Supported by county, state, federal and private funds, the program has county Extension offices statewide. Its headquarters is on the K‑State campus in Manhattan. For more information, visit www.ksre.ksu.edu. K-State Extension is an equal opportunity provider and employer.
Bull buying season is upon us! Whether you have already identified the sale and lot number you're going after or you're in the beginning stages of researching the advantages of Angus bulls, this episode is for you. Listen in as we visit with Troy Marshall, director of commercial industry relations with the American Angus Association, regarding: Making an Angus bull pencil out in your operation,Programs (and marketing opportunities) that calves sired by Angus bulls are eligible for, How additional data can help you make decisions in your cow herd,And more!A huge thank you to Purina for their sponsorship of this episode.Have questions or comments? We'd love to hear from you!Find more information to make Angus work for you in the Angus Beef Bulletin and ABB EXTRA. Make sure you're subscribed! Sign up here to the print Angus Beef Bulletin and the digital Angus Beef Bulletin EXTRA. Have questions or comments? We'd love to hear from you! Contact our team at abbeditorial@angus.org.
In this episode, Paige and Jamie from Real Food Recovery join us to explore the powerful intersection of holistic health, nervous system regulation, and long-term recovery from ultra-processed food addiction. They share why they wrote their book, the four core branches that anchor recovery, and why recovery isn't about perfection—it's about resilience, compassion, and sustainable support systems that hold us when life falls apart. With honesty and courage, Jamie shares her story of leaving an abusive relationship and navigating destabilization while protecting her recovery. Together, we dig into spirituality (beyond religion), harm reduction, abstinence debates, nervous system science, ego traps like "I'll start Monday," and how we can meet ourselves with clarity and grace instead of shame. This conversation is validating, empowering, and deeply human. Recovery isn't about mastering food—it's about building a life worth staying for.
Leave a message & include your contact or I won't know it's you.Free Starter Pack with "how to truly stay no contact" https://www.radiatenrise.com/survivor-starter-packIt's officially Hoover Season — that magical time of year when toxic exes suddenly remember you exist and send a “Merry Christmas ❤️” text that derails your entire night. If you've ever felt your heart drop, your stomach twist, or your brain spiral from one message… this episode is for you.We're breaking down why narcissists and emotionally abusive partners love the holidays, why they come back during December, and what their sudden “I've changed” or “I miss us” messages actually mean (spoiler: it's not love). You'll learn the psychology behind hoovering, how to decode the emotional bait, and why your nervous system reacts even when you know better.Inside this episode, you'll learn: ✨ The 6 flavors of holiday hoovering and how to spot each one ✨ How to decode the “Merry Christmas
Learn how to permanently heal from heartbreak or rejection, detach and move on to attract what's TRULY meant for you in this episode with Marcy Neumann, The HeartShift Coach. Here's where you can learn more about Marcy's new program, "Cracking Your Forgiveness Code": https://www.subscribepage.io/hh_forgiveness_journey Learn more about Marcy's "Self-Love For True Love" program here (use the coupon code LOVEIN2025 to get $70 off!): lovemyself.selfloveuniversity.com/self-love-for-true-love/k2a7o Check out Marcy's course, "Find Love Now: True Love Begins With A HeartShift In You" here (use the coupon code FINDLOVE150 to get 70% off!): https://lovemyself.selfloveuniversity.com/find-love-now/k2a7o Check out Marcy's course, "Removing Energetic Resistance: HeartShifting101" here (use the coupon code LOVE100 to get $100 off!): https://lovemyself.selfloveuniversity.com/removing-energetic-resistance-heartshifting-101/k2a7o You can get Marcy's Self-Love Starter Course here: https://lovemyself.selfloveuniversity.com/self-love-starter-course/k2a7o If you want to learn the secrets to attracting the man you want and inspiring his love, devotion and commitment, get my FREE "3 Keys To Attract The Man You Want" report and audio training here: http://helenahartcoaching.com/ Ever wonder why a guy pulls away even when he was interested and attracted to you at first? It's not you - it's something I call "The Heartbreak Treadmill." Discover how to stop this painful cycle, and what to do instead to bring a man closer than ever here: https://helenahart--mcoast.thrivecart.com/feminine/ Check out my eBooks and Programs here: http://helenahartcoaching.com/ebooks/ Here are the biggest Connection Barriers that push a man away (PLUS how to make him come back and want to stay forever): http://forever1234.com/ While I don't personally conduct one-on-one counseling, I'm sponsored by a company that can meet such a need if you'd like to get online therapy from a licensed professional (I've worked with a therapist from BetterHelp myself and it was absolutely life-changing!). You can get a discount through my exclusive invitation here: https://betterhelp.com/helenahart/ Subscribe to my YouTube channel: https://www.youtube.com/c/HelenaHartCoaching/ Connect with me on Facebook: https://www.facebook.com/helena.hart.10 Follow me on Instagram: https://www.instagram.com/helenahartcoaching/ Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
Charles Dickens’ classic tale of Ebenezer’s life-changing encounter with three spirits on Christmas Eve. Original Air Date: December 24, 193 Read more ...
Wellness House of Annapolis' Director of Counseling and Programs - Emma Rogers - says for those of us going through cancer, recently diagnosed with cancer, or have suffered the loss of someone from cancer… the joy of the holiday season exists in stark contrast to what they may be feeling…
Law enforcement Explorer programs were created to mentor teens interested in policing. But decades of weak oversight created an environment where officers could manipulate that trust. Some exploited their roles, using their authority to groom, abuse, and silence the very teens they were entrusted to guide.Resources:RAINN – Rape, Abuse & Incest National Network: 24/7 hotline and resources for survivors of sexual assault and abuse. Call 1-800-656-HOPE (4673) or visitrainn.orgNational Sexual Violence Resource Center (NSVRC): Research, education, and tools to support prevention and survivor recovery. Visitnsvrc.orgJoyful Heart Foundation: Works to transform the response to sexual assault, domestic violence, and child abuse, while supporting healing and survivor advocacy. Visitjoyfulheartfoundation.orgChildhelp National Child Abuse Hotline: Confidential support for anyone concerned about child abuse. Call 1-800-4-A-CHILD (1-800-422-4453) or visitchildhelphotline.orgVictimConnect Resource Center: Provides free, confidential support and referrals for people affected by crime, including sexual abuse and misconduct by authority figures. Call 1-855-4-VICTIM (855-484-2846) or visitvictimconnect.orgNational Child Traumatic Stress Network (NCTSN): Expert guidance, therapist locators, and educational tools for families navigating trauma and abuse. Visitnctsn.orgBloom365: Youth-focused organization working to end teen dating abuse, sexual violence, and trauma through prevention, peer advocacy, and healing services. Call or text the Bloom helpline at 1-888-606-HOPE (4673) or visitbloom365.orgCDC – Child Sexual Abuse Prevention: Evidence-based strategies and data about child sexual abuse in the U.S. Visit cdc.gov/violenceprevention/childsexualabuseState Child Abuse and Neglect Reporting Numbers: Directory to report child abuse to agencies. Visit childwelfare.gov/state-child-abuse-and-neglect-reporting-numbers988 Suicide & Crisis Lifeline: Provides 24/7, free and confidential support for people in distress, prevention and crisis resources. Call 988 or visit988lifeline.orgCrisis Text Line: 24/7 mental health support via text. Text "HOME" to 741741 or visitcrisistextline.orgNational Domestic Violence Hotline: Support for those experiencing abuse or coercive control. Call 1-800-799-SAFE (7233), text "START" to 88788, or visitthehotline.orgLove is Respect: Help for teens and young adults in abusive relationships.Call 1-866-331-9474, text "LOVEIS" to 22522, or visitloveisrespect.orgNational Center for Victims of Crime: Provides advocacy, legal information, and trauma-informed resources for survivors of sexual abuse, harassment, and exploitation. Visitvictimsofcrime.orgMale Survivor: Support for male survivors of sexual abuse and assault, including institutional or authority-based abuse. Visitmalesurvivor.orgStaying Safe in Youth Law Enforcement Programs:If you or your child is involved in a Police Explorer program – or any youth mentorship run by law enforcement – there are steps you can take to reduce risk and create safer boundaries.Ask direct questions. Who runs the program? What are the policies around texting, ride-alongs, and one-on-one interactions? Are there rules that limit contact between adult officers and minors outside of scheduled events?Insist on transparency. Reputable programs should have clear, written guidelines about communication, supervision, and conduct. Ask to see them.Monitor ride-alongs. Know who your child is riding with, how long they're gone, and what the reporting procedures are.Watch the tech. Officers or advisors should never be Snapchatting, DMing, or texting minors privately. Monitor app usage and discuss healthy boundaries.Get involved. Show up to meetings. Get to know the adults running the program. Your presence as a parent or guardian helps make the space safer for everyone.Keep communication open. Let your child know they can talk to you about anything -- especially if something makes them uncomfortable. Make it clear that they won't be in trouble for speaking up.Getting Help:If you or someone you know has experienced abuse in a Police Explorer or similar youth program, here's what to do:Believe them. If a child or teen discloses abuse, believe what they say. Stay calm, listen, and affirm that it's not their fault. Praise them for coming forward.Report it. If the child is in danger, call 911. Otherwise, contact your local police, sheriff's department, or state child protection agency. If you're concerned local police might have a conflict of interest, contact your state police, state attorney general, or the FBI.Document/preserve everything. Save messages, screenshots, call logs — anything that could help support the report.Seek emotional support: Abuse by a trusted adult is incredibly disorienting. You and/or your child deserve compassionate care from someone trained in trauma -- like a therapist, school counselor, or crisis line advocate.Connect with survivor resources. Many organizations offer specialized support for young people.Consult legal counsel: Some survivors explore civil legal action against individuals or institutions. An attorney familiar with institutional abuse cases can help assess your options.Red Flags: Signs of Grooming or Abuse in Explorer Programs:Abuse by authority figures often begins with grooming -- a gradual, often-subtle process that builds trust before violating it. Here are common warning signs in youth law enforcement programs:“Special” treatment. One teen is singled out for attention, gifts, mentorship, or exclusive opportunities not given to others.Excessive one-on-one contact. Repeated private ride-alongs, late-night messages, or invitations to hang out off-duty.Private communication. The adult uses personal texting apps, Snapchat, Instagram DMs, or other unmonitored channels to talk to a minor.Overstepping/blurring boundaries. Inappropriate compliments, jokes about relationships, or sharing personal details not appropriate for a mentor-mentee dynamic.Isolation. The adult discourages the teen from talking to others about their relationship or makes the teen feel responsible for their secrecy.Gaslighting or guilt. The adult blames the teen for misunderstandings, manipulates their emotions, or makes them feel they'll “ruin someone's life” if they speak out.Physical contact. Touch that's unnecessary, prolonged, or makes the teen uncomfortable -- even if it's framed as casual or accidental. You can learn more about The Good segment and even submit a story of your own by visiting The Good page on our website! Source materials for this episode cannot be listed here due to character limitations. For a full list of sources, please visit: https://crimejunkiepodcast.com/scandal-police-explorer-programs/Did you know you can listen to this episode ad-free? Join the Fan Club! Visit https://crimejunkiepodcast.com/fanclub/ to view the current membership options and policies.Don't miss out on all things Crime Junkie!Instagram: @crimejunkiepodcast | @audiochuckTwitter: @CrimeJunkiePod | @audiochuckTikTok: @crimejunkiepodcastFacebook: /CrimeJunkiePodcast | /audiochuckllcCrime Junkie is hosted by Ashley Flowers and Brit Prawat. Instagram: @ashleyflowers | @britprawatTwitter: @Ash_Flowers | @britprawatTikTok: @ashleyflowerscrimejunkieFacebook: /AshleyFlowers.AF Text Ashley at 317-733-7485 to talk all things true crime, get behind the scenes updates, and more! Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
Chris Simonsen joins Dr. Sandie Morgan as they explore how communities can close the gap that makes young people vulnerable to trafficking—not with rescue mentalities, but with trauma-informed care, consistent relationships, and spaces where young people feel safe enough to stay. Chris Simonsen Chris Simonsen is the Chief Executive Officer of Orangewood Foundation, one of Orange County's leading organizations serving youth who have experienced abuse, neglect, homelessness, and exploitation. With more than fifteen years at the helm and over three decades of executive leadership experience, Simonsen oversees a comprehensive continuum of care that includes housing, education, transitional support, wellness services, and specialized programs for youth who have been exploited or trafficked. Under his leadership, Orangewood has expanded its focus on intervention for children and Transitional Age Youth (TAY), emphasizing strategies that prevent revictimization, stabilize immediate crises, and strengthen long-term resilience. Simonsen's leadership is shaped by a commitment to relationship-based, trauma-informed care and a theory of change rooted in the belief that consistent adult support, safe environments, and practical resources dramatically alter a young person's trajectory. Key Points Orangewood Foundation made a strategic decision ten years ago to remove all labeling criteria for their programs, allowing them to serve any teen or young adult in need regardless of foster care status or county of residence, which caused the organization to grow from 40 to 250 employees. The number one priority when working with vulnerable youth is building a trusting relationship and creating a safe environment where they feel comfortable, which can take weeks or months before meaningful goal-setting work can begin. Young people without support structures are highly vulnerable to traffickers, and their trauma is so much more complex that Orangewood created dedicated programming including the Lighthouse transitional housing program and Project Choice drop-in center specifically for survivors and at-risk youth. Prevention work must address the developmental realities of youth who haven't had long-term stability or supportive infrastructure, including implementing social-emotional support in schools through programs like advisory groups that stay together for four years. The role of loneliness and connection is critical—young people need to build their own communities and peer support networks, not just rely on organizational staff, to develop healthy relationships and long-term resilience. For those wanting to help, the most effective approach is to support existing trauma-informed organizations through volunteering, donations, or collaboration rather than starting new nonprofits, and to get educated on what human trafficking really is before attempting direct intervention. Schools need to dedicate more resources to the social-emotional aspects of teenagers' lives, not just academics, and provide direct education to students about trafficking prevention at appropriate age levels without parental pushback. The Ending Human Trafficking Collaborative led by the Samueli Foundation exemplifies how community education and cross-sector partnerships can strengthen prevention efforts by bringing together experts and philanthropists to direct resources where they're most needed. Resources Orangewood Foundation Samueli Academy Project Choice (Orangewood Foundation) Lighthouse Transitional Housing Program (Orangewood Foundation) Ending Human Trafficking Podcast Global Center for Women and Justice - Vanguard University Orange County Human Trafficking Task Force Samueli Foundation Transcript [00:00:00] Chris Simonsen: The number one thing we have to do initially with any of our young people is build a trusting relationship with them. [00:00:07] Make them feel comfortable.
Mid-major Division I baseball programs don't always have the biggest budgets, flashiest facilities, or national spotlight — but many consistently develop high-level players. In this episode, we break down how great coaching becomes the competitive advantage.We dive into how mid-major D1 staffs focus on individualized player development, teaching fundamentals, and building repeatable routines that translate to game performance. Without relying on star recruits or unlimited resources, these programs emphasize skill growth, baseball IQ, physical development, and mental toughness.The conversation also covers how coaches identify under-recruited players, create clear development plans, and hold athletes accountable in an environment where development isn't optional — it's the priority. From practice structure to feedback systems, we explore what separates programs that consistently improve players from those that don't.Whether you're a player navigating the recruiting process, a parent trying to understand different D1 environments, or a coach looking for development ideas, this episode offers an inside look at why great coaching — not resources — is often the biggest driver of success at the mid-major level.
It's important that agents are equipped to handle Medicare grievances when they arise. Listen to learn how to prepare and best practices for avoiding these situations. Read the text version
Julie A. Parsons, MD Haberfield Endowed Chair in Pediatric Neuromuscular DisordersProfessor of Clinical Pediatrics and NeurologyUniversity of Colorado School of Medicine, Children's Hospital ColoradoAurora, CO, USAAs we talk about the gene transfer therapies and the modalities that we have to use, it's really interesting. Yesterday, with our keynote speaker, you could see this logarithmic growth of the use of gene transfer therapies for these disorders. If you look at the Venn diagram, you can see that really 27% almost of gene transfer therapies that are used are in musculoskeletal and neurology. For many of us as neurologists, we also take care of metabolic disorders.We really own right now this landscape, and of course, our two approved modalities are Onasemnogene and Delandistrogene. We're going to look at three different disorders, monogenic disorders, monogenic diseases, to typify what we look at in terms of some of the risks and benefits of these treatments. SMA, Duchenne, and X-linked myotubular myopathy are all rare disorders. They're all diseases that have a high unmet medical need and a significant disease burden.I think they're all good in terms of typifying where we are clinically with these disorders. The first question is, is it worth it? Are these effective treatments? We know from looking at the information about SMA that just looking early on, we know that if we treat kids early, that we do see a marked improvement in motor scores for kids that are treated early with Onasemnogene.In Duchenne, we have information that there is at least some improvement in the 4-5-year-olds in terms of motor skills treated with Delandistrogene. In terms of X-linked MTM, which was a very dramatic improvement, you could see that for boys who were basically traked, vented, and had no mobility, the bottom line, the blue line, is actually looking at ventilator dependence. Are they effective? Yeah, they're effective, but then we have to say, okay, what's the downside?The downside is that there's tremendous risk associated with treatment with these agents. If we really look at the sobering facts, we know that with SMA, there have been deaths, there have been fatalities related to thrombotic microangiopathy to patients who have liver failure, a couple of patients have died. With Onasemnogene, this is 4,000 plus doses that have so far been given. With Duchenne, unfortunately, many of us got the letter yesterday talking about an additional death in a patient treated with commercial Delandistrogene.We also know with some of the other agents, like fordadistrogene, patient died of heart failure, cardiac arrest, another patient who had acute respiratory syndrome with pulmonary edema. Again, we look at this and say this is significant. With X-linked MTM, as Alan said, there were some unanticipated deaths, four deaths from patients who ended up having cholestatic liver diseases that really wasn't anticipated prior to the patients being treated with the animal models and all that we had. Then many of you have heard about the patient with Rett syndrome who had a systemic hyperinflammatory syndrome. Again, these are rare disorders. They have a high disease burden, but the risk of treatment is significant.In the next part, Dr. Parsons discuss factors impacting safety and efficacy of AAV-mediated gene therapies.
Julie A. Parsons, MD Haberfield Endowed Chair in Pediatric Neuromuscular DisordersProfessor of Clinical Pediatrics and NeurologyUniversity of Colorado School of Medicine, Children's Hospital ColoradoAurora, CO, USAHow have programs adapted to the experiences from clinical trials? I'm just looking at SMA because we've had SMA. We've had onasemnogene around for the longest period of time. We want to always confirm a diagnosis and know that the patient is right. We do antibody testing for these disorders prior to delivering the AAV therapies. We have to know that the product that is incredibly expensive is handled appropriately by the institution. Dealing with the pharmacy, making certain that you handle the agent properly, patients need to be pretreated at this point with prednisone, and that really has to happen so that you know that they're ready for treatment, that they don't have any infections prior to treatment.Then we need to monitor and provide medication and follow-up afterwards. As I said, I think this is really, really important to make sure that you're connected well with the patient. If you live in an area as we do, that has a huge catchment area with patients that come from hundreds of miles away, sometimes they need to stay with us for a period of time, so that we can ensure the safety and follow-up of these patients after we deliver gene therapies.Again, a recurring theme is the patients that you're treating who are not in a clinical trial are not the homogeneous, well-selected patients. It's really all actors. The population that you're treating commercially is very different. We're now moving into treating patients with larger body masses and older ages. We don't always know, because those patients haven't really been included in the clinical trials. We don't really know what some of the effects are going to be with that group of patients as well.I am a neurologist. I am not an immunologist. I have had to learn a lot of immunology at this point, but it's still not sufficient. I think that we also need to reach out to our subspecialist colleagues who really do have more experience than we do to try to help us with some of these issues, because as we look at these viral vector capsids and the transgenes, we have to say, is there something that we can do to mitigate the immune response that we're seeing when we're giving massive doses of these agents and really taxing the immune system in our patients?Looking at possibilities, we give steroids, and that's really what we've done. That was what was done in the early clinical trials with MENDEL. It's like, okay, prednisone, that's all we have to do is we give steroids and everybody will be fine. That really isn't maybe the answer. As we have more information, we know that we're going to start with steroids, but we're really going to look at, is there a way to block both the B-cell response, the T-cell response? Is there something that we can do so that we don't have to sit on the edge of our seats and not sleep for months after we treat these patients?At least in a trial, was done looking at patients who were treated just with corticosteroids. Those patients had rapid increases in IgM and IgG. There's complement activation. Both the adaptive and the acute immune responses are triggered. That's really what we're doing as standard practice right now, but in the trial looking at treating patients and pretreating patients with rituximab blocking B cells and sirolimus and corticosteroids, then no significant change in IgM, IgG.Is that something that we should be doing? I think that some of the clinical trials that are being set up are looking at instituting some of these immune-modulating features to see whether or not their outcomes are improved. Can we do anything proactively to prevent our patients from having some of these very severe events or fatalities? I think that's really what we need to be looking at now. I think we are looking at that as a community, and to me, is a story that is still unfolding in terms of how we keep our patients safe.In the next part, Doctors Beggs and Parsons will discuss key issues on gene therapy development.
Alan Beggs, PhDDirector of the Manton Center for Orphan Disease ResearchSir Edwin and Lady Manton Professor of Pediatrics, Boston Children's HospitalHarvard Medical School, Boston, MA, USAThe challenges that you've heard about are real. Some of them I think we could have foreseen others. There was no way to know until we actually started treating patients in clinic. But we now know that there are immune responses and also responses just to the viral load. As Julie mentioned, we're giving massive doses to these patients on the order of one times ten to the 14 viral genomes per kilogram.Think about the fact that when these capsids are manufactured, there's a certain percentage of empty capsid. The amount of protein that's being delivered to these patients can be massive. One of the approaches to mitigate some of the risk would be to lower the dose. While early studies demonstrated that in order to get adequate delivery to skeletal muscle, you need to give these very large doses. But what if we could engineer a viral capsid that would be potent at lower doses?There has been quite a bit of research in this area that's ongoing, and some new next generation vectors that are just starting to enter the clinic. In particular, there are a class of Myotropic viral vectors or capsids so-called RGD vectors. RGD refers to arginine, glycine, and aspartic acid, which are three residues which, when present at a particular point in the viral capsid proteins interact with integrin receptors that are specific for skeletal muscle. These viral capsids home to skeletal muscle and can deliver their genetic payload at much lower doses. There was one group of these developed in Germany by Theo Grimm's lab.These were the so-called AAV Myos, and simultaneously in Boston at the Broad Institute, a group of capsids was developed that were called Myo AAV. These were both based off of an AAV nine backbone. It's basically an AAV nine legacy vector with these three amino acids changed. Now Solid Biosciences also has their own independently derived vector that I believe is also an RGD vector. These vectors give us the potential then for more efficient and specific delivery to muscle cells.They may or may not target the liver depending on the particular virus. Some of them the risk to the liver is mitigated by delivering a lower dose. You can also develop these vectors in a way that will be liver targeted, that specifically less of it gets delivered to the vectors. These would be really, in my mind potentially third generation vectors.Strategies, there are a number of strategies. You heard about the immunomodulation regimens. I just talked about optimizing vector design. Also, Doctor Parsons mentioned earlier the fact that where you deliver so zolgensma is delivered Intrathecally. We get it to the place we need it, and we're less likely to have off target effects through other tissues.Then improved manufacturing is very important. I mentioned the fact that every viral preparation contains empty capsids. There are ways to minimize the production of empty capsids, and also effective ways to filter out and remove those empty capsids. This is actually a very important aspect that is being developed further by the CMO community. Then in summary, I think it's important to take a holistic approach when we're thinking about the development of AAV based gene therapies for neuromuscular disease.It starts from the fact that for any given disease we're interested in, we need to define the genetic etiology. Since these are gene directed therapies. We need to pay careful attention to the preclinical animal models. How accurately do they really reflect the human condition? Or are there potentially responses in our human patients that we haven't experienced in the animals? It's important to understand the natural history and the patient population.Recognize that there's extensive heterogeneity, not just in age and severity, but also potentially in underlying susceptibilities in our patients. We have a group of toxicities that we know about and can anticipate. But as Julie was saying, you need to be really careful and think about any potential unexpected SAEs. And then finally I mentioned the manufacturing aspect, the development of newer vectors and quality control aspects that go into making a safe and effective therapeutic.In the next part. Doctor Parsons will discuss clinical safety and efficacy observed in AAV mediated gene therapy programs in DMD, SMA, and XLMTM.
Big Tobacco's playbook is back — just with better branding and candy flavors. Jessica Wynn clears the air about vaping here on Skeptical Sunday!Welcome to Skeptical Sunday, a special edition of The Jordan Harbinger Show where Jordan and a guest break down a topic that you may have never thought about, open things up, and debunk common misconceptions. This time around, we're joined by writer and researcher Jessica Wynn!Full show notes and resources can be found here: jordanharbinger.com/1260On This Week's Skeptical Sunday:Vapes don't produce harmless vapor. They emit aerosol, a "chemical soup" containing nicotine, heavy metals like lead and nickel, formaldehyde, and ultrafine particles that penetrate deep into lungs where filtration is impossible.JUUL revolutionized addiction by using nicotine salts instead of freebase nicotine — lowering the pH for smoother hits at higher concentrations, delivering a faster brain rush with less coughing, and packing one pod with the equivalent of an entire pack of cigarettes.Many vapes labeled "nicotine-free" actually contain nicotine when tested, and secondhand aerosol isn't safe either — it deposits residue on surfaces, harms pets, and exposes bystanders to the same toxic cocktail inhaled by the vaper.The same playbook Big Tobacco used for decades — targeting kids, using candy flavors, buying off scientists, and fighting regulation — is now deployed through sleeker devices and better branding.Quitting is possible, and the tools actually work. Programs like the Truth Initiative's "This Is Quitting" show 40% higher quit rates, and texting DITCHVAPE to 88709 connects you with free, judgment-free support designed for real people fighting real addiction.Connect with Jordan on Twitter, Instagram, and YouTube. If you have something you'd like us to tackle here on Skeptical Sunday, drop Jordan a line at jordan@jordanharbinger.com and let him know!Connect with Jessica Wynn at Instagram and Threads, and subscribe to her newsletters: Between the Lines and Where the Shadows Linger!And if you're still game to support us, please leave a review here — even one sentence helps! Sign up for Six-Minute Networking — our free networking and relationship development mini course — at jordanharbinger.com/course!Subscribe to our once-a-week Wee Bit Wiser newsletter today and start filling your Wednesdays with wisdom!Do you even Reddit, bro? Join us at r/JordanHarbinger!This Episode Is Brought To You By Our Fine Sponsors: Uplift Desk: Special offer: upliftdesk.com/jordanWayfair: Start renovating: wayfair.comShopify: 3 months @ $1/month (select plans): shopify.com/jordanApretude: Learn more: Apretude.com or call 1-888-240-0340Homes.com: Find your home: homes.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
The Comic Weekly Man comes for a weekly visit right before Christmas and reads strips from Puck: The Comic Weekly, including Flash Gordon, Dick’ Read more ...
Leaving a relationship rarely happens in one big, dramatic final moment. Instead it happens discreetly, in the stories you stop sharing, the tension you learn to live with, and the gut feelings you keep pushing away.In this episode, I walk you through six powerful signs your relationship may be coming to an end. Not to convince you to leave, but to help you listen more honestly to yourself about what they may mean. This isn't an episode about giving up on relationships.It's about unlearning the belief that love means enduring at your own expense, and recognising the difference between healthy effort and emotional self-abandonment.If you've ever found yourself thinking, “I don't know if this is bad enough to leave,” or “is this really it?" this conversation is for you.By the end of this episode, my hope is that you feel clearer, more grounded, and more connected to your own truth whatever your next move.With love, always,LouisaSocials, Programs & More from Unlearn with Louisahttps://linktr.ee/unlearnwithlouisaCoaching Questions & Enquiriescoaching@unlearnwithlouisa.comPodcast Questions & Enquiriespodcast@unlearnwithlouisa.com
Blizzard conditions are impacting much of the Red River Valley today. Snow, falling heavily at times this morning, will total 3-4 inches, with totals closer to 2 inches for the Fargo-Moorhead area and Fergus Falls. Expect high winds gusting to 50-60 mph along the western edge of Minnesota as temperatures drop into the single digits. There's a chance of snow statewide Thursday.The first person charged in a scheme to defraud a state program for children with autism is expected to plead guilty Thursday morning. Asha Hassan is also charged with ripping off taxpayer-funded child nutrition programs.The 29-year-old is alleged to have bilked Minnesota's Early Intensive Developmental and Behavioral Intervention program out of more than $14 million and used some of that to pay kickbacks to the parents. Six Minnesotans are suing U.S. Immigration and Customs Enforcement, alleging that federal agents violated their rights while they were observing immigration arrests. The ACLU and several law firms filed the lawsuit Wednesday on behalf of the plaintiffs. They say federal agents detained or threatened people who were not breaking any laws.One of the men arrested by ICE agents at a construction site in Chanhassen last weekend has filed a petition in federal court seeking release.
Former co-host and semi-regular guest Bri Gerzevske stops by the Lounge for a holiday visit — and this time, she's mining her own recent life experience to offer Sarah, Erin, and Rachel her expert “Guide to a Fun and Fabulous Christmas Program at Church.” Among Bri's words of wisdom are these key takeaways: Don't go it alone! YOU NEED A VILLAGE FOR THIS. Treat the kids like “professionals.” Show gratitude by keeping the main thing the main thing. “Producing a children's Christmas program is hard work,” Bri says, “but it's deeply fulfilling. With collaboration, joyful structure, child empowerment, and gratitude, the program becomes meaningful for everyone. True ‘success' lies not in perfection, but in ministry, community, and shared joy.” Brianne Gerzevske is a fellow Lutheran lady, LCMS pastor's wife, and director of managed contributor care for LCMS Mission Advancement. She is a former co-host of The Lutheran Ladies' Lounge and remains a regular guest and occasional contributor to the program. Connect with the Lutheran Ladies on social media in The Lutheran Ladies' Lounge Facebook discussion group (facebook.com/groups/LutheranLadiesLounge) and on Instagram @lutheranladieslounge. Follow Sarah (@hymnnerd), Rachel (@rachbomberger), and Erin (@erinaltered) on Instagram! Sign up for the Lutheran Ladies' Lounge monthly e-newsletter here, and email the Ladies at lutheranladies@kfuo.org.
Davit Karapetyan and Laura Bowman Goldstein from Philadelphia Ballet break down three focused summer programs designed for dancers considering specialized training: the Pas de Deux Intensive, Variations Intensive, and Company Experience. They start with partnering, an essential skill that many students cannot get in their local schools. Davit and Laura talk about how much partnering really matters in today's job market, what experience dancers need going in, and how this intensive tackles the challenges students struggle with most. Next, they dive into the Variations Intensive, where dancers receive targeted competition coaching and individualized feedback. They explain why dedicated variation work matters, how pieces are chosen, and what dancers can expect from the final showing. Finally, the Company Experience offers a taste of professional life, with daily training and direct access to Philadelphia Ballet's artistic staff. The conversation covers schedules, repertoire, and how often students move from this program into trainee, second company, or even the main company. Davit and Laura also share guidance for dancers and parents trying to decide which program makes the most sense, and what sets Philadelphia Ballet's summer training apart. If you are looking beyond a traditional summer intensive, this episode lays out three distinct options and who each one is really for. Learn more about Philly's summer programs. Links: Read Our Ballet School Summer & Year-Round Reviews: https://reviews.ballethelpdesk.com/ Buy Corrections Journals Support Ballet Help Desk Instagram: @BalletHelpDesk Facebook: BalletHelpDesk TikTok: Music from #Uppbeat: https://uppbeat.io/t/ian-aisling/new-future License code: MGAW5PAHYEYDQZCI
Andy Linerud, Chair of the RCC Foundation Board joins the Exchange along with Randy Weber, the president of Rogue Community College.
Today’s Story: A writer who has cast herself as America’s favorite homemaker in her columns faces ruin when her publisher and a war-hero sai Read more ...
Who is hiding the truth about UFOs? Are UAP actually secret government weapon programs? In this full length documentary (created from a supercut of our IRONCLAD Original series, Black Project), Andy Stumpf talks with experts, whistleblowers, and insiders including Dr. Garry Nolan, Rep. Tim Burchett, Chrissy Newton, Richard Dolan, and others to get to the bottom of the mystery. Change Agents: Black Project is an IRONCLAD Original Sponsors: Firecracker Farm Use code IRONCLAD to get 15% off your first order at https://firecracker.farm/ Hollow Socks For a limited time Hollow Socks is having a Buy 2 , Get 2 Free Sale. Head to http://Hollowsocks.com today to check it out. #HollowSockspod Mizzen and Main Get 20% off your first purchase at https://www.mizzenandmain.com with promo code IRONCLAD20 Delete Me Go to https://www.joindeleteme.com/IRONCLAD and use coupon code IRONCLAD, or scan the QR code SYNC ID MB01RN0TOTXIJJR Learn more about your ad choices. Visit megaphone.fm/adchoices
From August to December 2016, then Marine Special Operations Officer Ivan Ingraham lived on an assault ship off the coast of Sirte, a city in northern Libya that lies between Tripoli and Benghazi. It was the hometown of Muammar Gaddafi, who invested in Sirte before dying there during Libya's first civil war. In the midst of a second civil war, ISIS had filled a power vacuum and overrun the city, sending its civilians fleeing. At the request of Libya's UN-backed Government of National Accord, the United States provided support. Ivan led a five-man special operations team attached to a Marine Expeditionary Unit to help push ISIS out. The mission was known as Operation Odyssey Lightning. Subscribe to Sasha's Substack, HUMINT, to get more intelligence stories: https://sashaingber.substack.com/ For more information about the International Spy Museum, visit: https://www.spymuseum.org/ And if you have feedback or want to hear about a particular topic, you can reach us by E-mail at SpyCast@Spymuseum.org. This show is brought to you from Goat Rodeo, Airwave, and the International Spy Museum in Washington, DC. This episode was produced by Flora Warshaw and the team at Goat Rodeo. At the International Spy Museum, Mike Mincey and Memphis Vaughan III are our video editors. Emily Rens is our graphic designer. Joshua Troemel runs our SPY social media. Amanda Ohlke is our Director of Adult Education and Mira Cohen is the Vice President of Programs. Learn more about your ad choices. Visit megaphone.fm/adchoices
Nongovernmental organizations (NGO's) are about to lose a great deal of federal government money. Secretary of State Marco Rubio has said that tax dollars meant for foreign aid have instead been heavily used to prop up NGOs. And many NGOs have gotten involved in programs that facilitate mass migration, in what's now being referred to as the “refugee industrial complex.”We'll discuss this topic and others in this episode of “Crossroads.”Views expressed in this video are opinions of the host and guests, and do not necessarily reflect the views of The Epoch Times.