Podcasts about Pathophysiology

This is part 2 of a 3 part series on hypertensive disorders of pregnancy. Part one with Joe Navarrete covered the baseline physiologic changes with pregnancy. In this episode, David Barksdale is going to walk us through the pathophysiology of hypertensive disorders of pregnancy. And in the next episode, Isabella Sosa joins us to walk […]

This week, Aebhric talks with Jason Jarvis, a former Special Forces medic and current PhD candidate, and discusses Chagas disease, a tropical disease transmitted by the kissing bug. He explains the life cycle of the bug, the transmission of the disease, its clinical presentation, and the challenges in diagnosis and treatment. The conversation emphasises the importance of awareness and preventive measures, especially as Chagas disease is spreading to new regions, including parts of the United States. The discussion concludes with key take-home messages for healthcare providers and the need for ongoing education in tropical medicine.TakeawaysChagas disease is transmitted by the kissing bug, primarily in Central and South America.The life cycle of the kissing bug involves several stages, including the transmission of the parasite through its faeces.Clinical diagnosis is essential, especially in endemic areas where the disease is prevalent.The acute phase of Chagas disease is easier to treat than the chronic phase, which can lead to severe complications.Preventive measures include avoiding exposure to kissing bugs and ensuring blood products are screened for the disease.Chagas disease can also be transmitted through blood transfusions and organ transplants.Healthcare providers should be aware of the symptoms and risk factors associated with Chagas disease.The disease is now spreading to parts of the continental US, raising public health concerns.Ongoing education and awareness of tropical diseases are crucial for healthcare providers.The conversation highlights the importance of understanding the global health implications of diseases like Chagas. Chapters00:00 Introduction to Chagas Disease and Its Relevance02:36 Life Cycle of the Kissing Bug and Transmission of Chagas Disease04:58 Understanding the Pathophysiology of Chagas Disease07:31 Clinical Presentation and Diagnosis of Chagas Disease10:18 Chronic Phase and Long-term Effects of Chagas Disease12:41 Treatment Options and Challenges in Managing Chagas Disease14:51 Preventive Measures and Risk Factors for Chagas Disease17:39 Chagas Disease in the Context of Global Health19:42 Take-Home Messages for Healthcare Providers22:20 Future Considerations and Closing Thoughts

*Content Warning: distressing themes, self-harm, rape, substance abuse, substance use disorder, child abuse, verbal abuse, mental abuse, physical abuse, institutional abuse, childhood sexual abuse, sexual abuse, suicidal ideation, death, and suicide. *Free + Confidential Resources + Safety Tips:  somethingwaswrong.com/resources    Snag your ticket for the live Home for the Holidays event here: https://events.humanitix.com/swwxtgi  Check out our brand new SWW Sticker Shop!: https://brokencyclemedia.com/sticker-shop  *SWW S23 Theme Song & Artwork:  The S24 cover art is by the Amazing Sara Stewart Follow Something Was Wrong: Website: somethingwaswrong.com  IG: instagram.com/somethingwaswrongpodcast TikTok: tiktok.com/@somethingwaswrongpodcast  Follow Tiffany Reese: Website: tiffanyreese.me  IG: instagram.com/lookieboo *Sources  Deseret News, and Amy Joi Bryson. “Teen Facility Targets Suicide Prevention.” Deseret News, Deseret News, 14 Jan. 2024, www.deseret.com/2004/7/30/19842793/teen-facility-targets-suicide-prevention Fuchs, David. “Utah Has Seen Abuse in ‘troubled Teen' Programs for Decades. Now, Momentum Slowly Builds for Change.” KUER, KUER, 24 Mar. 2021, www.kuer.org/health-science-environment/2020-12-17/utah-has-seen-abuse-in-troubled-teen-programs-for-decades-now-momentum-slowly-builds-for-change Institute of Medicine (US) Committee on Pathophysiology and Prevention of Adolescent and Adult Suicide; Goldsmith SK, Pellmar TC, Kleinman AM, et al., editors. Reducing Suicide: A National Imperative. Washington (DC): National Academies Press (US); 2002. 5, Childhood Trauma. Available from: https://www.ncbi.nlm.nih.gov/books/NBK220932/ Kubler, Katherine, creator and director. The Program: Cons, Cults and Kidnapping. Netflix, 2024 https://www.imdb.com/title/tt31183637/  Lopez-Castroman, Jorge et al. “Early childhood sexual abuse increases suicidal intent.” World psychiatry : official journal of the World Psychiatric Association (WPA) vol. 12,2 (2013): 149-54. doi:10.1002/wps.20039 https://pmc.ncbi.nlm.nih.gov/articles/PMC3683267/ Myers et al v. Dr. Phil Organization et al, No. 1:2014CV00007 - Document 77 (D. Utah 2015) :: Justia, law.justia.com/cases/federal/district-courts/utah/utdce/1:2014cv00007/91862/77/ Reavy, Pat. “Family Sues Dr. Phil, Utah Treatment Center.” Deseret News, Deseret News, 28 Dec. 2023, www.deseret.com/2014/1/29/20534024/family-sues-dr-phil-utah-treatment-center/

*Content Warning: distressing themes, suicide, death, substance use disorder, drug use, sexual assault of a child, institutional child abuse, violence, childhood abuse.  *Free + Confidential Resources + Safety Tips:  somethingwaswrong.com/resources    Snag your ticket for the live Home for the Holidays event here: https://events.humanitix.com/swwxtgi  Check out our brand new SWW Sticker Shop!: https://brokencyclemedia.com/sticker-shop  *SWW S23 Theme Song & Artwork:  The S24 cover art is by the Amazing Sara Stewart Follow Something Was Wrong: Website: somethingwaswrong.com  IG: instagram.com/somethingwaswrongpodcast TikTok: tiktok.com/@somethingwaswrongpodcast  Follow Tiffany Reese: Website: tiffanyreese.me  IG: instagram.com/lookieboo *Sources  Easton, Scott D et al. “Suicide attempts among men with histories of child sexual abuse: examining abuse severity, mental health, and masculine norms.” Child abuse & neglect vol. 37,6 (2013): 380-7. doi:10.1016/j.chiabu.2012.11.007 https://pubmed.ncbi.nlm.nih.gov/23313078/ Institute of Medicine (US) Committee on Pathophysiology and Prevention of Adolescent and Adult Suicide; Goldsmith SK, Pellmar TC, Kleinman AM, et al., editors. Reducing Suicide: A National Imperative. Washington (DC): National Academies Press (US); 2002. 5, Childhood Trauma. Available from: https://www.ncbi.nlm.nih.gov/books/NBK220932/ Kubler, Katherine, creator and director. The Program: Cons, Cults and Kidnapping. Netflix, 2024 https://www.imdb.com/title/tt31183637/  Lopez-Castroman, Jorge et al. “Early childhood sexual abuse increases suicidal intent.” World psychiatry : official journal of the World Psychiatric Association (WPA) vol. 12,2 (2013): 149-54. doi:10.1002/wps.20039 https://pmc.ncbi.nlm.nih.gov/articles/PMC3683267/

Sara dives into one of the most unforgettable parts of drinking → hangovers. From her worst-ever hangover in Punta Cana to the subtle shame-filled Sundays that followed too many nights out, Sara breaks down how hangovers evolved throughout her drinking years and how they became one of the biggest motivators for her sobriety. She doesn't stop at personal stories. Sara also explores the science of hangovers: what's actually happening inside your body and brain when you're feeling miserable the next day. You'll learn why alcohol leads to dehydration, inflammation, anxiety, and that 3 a.m. wake-up, plus why “hair of the dog” only keeps the cycle going. If you've ever wondered why hangovers hit so hard or need a vivid reminder of what you're leaving behind, this episode is your reality check and your motivation to keep choosing a hangover-free life. 00:00 Introduction to the Podcast and Today's Topic 02:28 The Worst Hangover Experience 09:00 Evolution of Hangovers Over the Years 15:34 The Science Behind Hangovers 25:06 Conclusion

In this solo episode, Darin pulls back the curtain on one of the most important parts of his life:  he prepares for travel. From the supplements that keep his immune system strong to hydration hacks, adaptogenic elixirs, and EMF protection, this episode is a masterclass in staying grounded and resilient on the road. Travel doesn't have to destroy your health — it can actually elevate it. With a few intentional rituals, smart packing, and awareness, you can turn every trip into an opportunity to deepen your energy, focus, and connection to yourself. What You'll Learn 00:00:00 – Why travel is stressful and how to transform it into an empowering, health-boosting experience 00:01:00 – Darin's supplement protocol: Vitamin D3/K2, probiotics, zinc, vitamin C, and glutathione for immune defense 00:03:00 – The antioxidant power of glutathione and why it's critical for long flights and radiation exposure 00:04:30 – How CBD and terpenes support stress resilience and circadian rhythm through the endocannabinoid system 00:05:20 – Why magnesium and NAD are the unsung heroes of travel recovery and energy 00:06:30 – Darin's morning elixir recipe: cacao, guarana, ashwagandha, chaga, ginseng, and monk fruit 00:08:00 – Hydration 101: how to use a manual RO filter, mineralize your water, and ditch plastic 00:10:00 – How to build nutrient density into travel days using chlorella, spirulina, Shakeology, and Barukas 00:12:00 – Travel nutrition sovereignty: packing your own snacks, fasting, and avoiding airline food 00:14:00 – Movement anywhere: Darin's “portable gym” using bungee cords and bodyweight routines 00:16:00 – The 3-hour morning ritual: NewCalm, Healing Codes, journaling, cacao, red light therapy, and breathwork 00:20:00 – How to avoid radiation scanners, mitigate EMFs, and use WaveGuard for energy field protection 00:22:00 – Why Darin microdoses nicotine for cognitive focus and immune modulation 00:23:00 – Breathing practices for immune strength: 3–4 rounds of 40 deep breaths, Wim Hof style 00:24:00 – How to pack fruit and salads in mason jars to stay hydrated and nourished on planes 00:26:00 – Grounding after flights: barefoot on the earth, morning sunlight, and re-aligning your circadian rhythm Thank You to Our Sponsors Manna Vitality: Go to mannavitality.com/ or use code DARIN20 for 20% off your order. Fatty15: Get an additional 15% off their 90-day subscription Starter Kit by going to fatty15.com/DARIN and using code DARIN at checkout. Find More from Darin Olien: Instagram: @darinolien Podcast: SuperLife Podcast Website: superlife.com Book: Fatal Conveniences Key Takeaway “Preparation is sovereignty. When you take responsibility for your nutrition, your hydration, and your energy before you travel, you're no longer surviving the trip — you're expanding through it.” Bibliography Martineau AR et al. Vitamin D supplementation to prevent acute respiratory infections: systematic review. BMJ. 2017. Goldenberg JZ et al. Probiotics for prevention of respiratory infections. Cochrane Database. 2017. Hemilä H. Vitamin C and zinc in common cold. Nutrients. 2017. Blessing EM et al. Cannabidiol as a potential treatment for anxiety disorders. Neurotherapeutics. 2015. Morris HJ et al. Spirulina and chlorella as functional foods. Nutrients. 2022. Longo VD, Panda S. Fasting, circadian rhythms, and time-restricted feeding. Cell Metabolism. 2016. Booth FW et al. Waging war on physical inactivity. J Physiol. 2017. Balmori A. Electromagnetic pollution from radiofrequency fields. Pathophysiology. 2015. Kox M et al. Voluntary activation of sympathetic nervous system and attenuation of the innate immune response. PNAS. 2014.

High Yield Antiarrhythmic Drugs Review:Class I (Sodium Channel Blockers)Class II (Beta Blockers)Class III (Potassium channel blockers)Class IV (Calcium Channel Blockers) for your PANCE, PANRE, Eor's and other Physician Assistant exams.Review for your PANCE, PANRE, Eor's, Physician Assistant exams, Medical, USMLE, Nursing Exams.►Paypal Donation Link: https://bit.ly/3dxmTql (Thank you!)Included in review: Pathophysiology of antiarrhythmics, cardiac action potential, phases 0–4, Phase 0 depolarization, Phase 1 initial repolarization, Phase 2 plateau, Phase 3 repolarization, resting membrane potential, cardiomyocytes, pacemaker cells, funny current (If), L-type calcium channels, T-type calcium channels, effective refractory period (ERP), conduction velocity, reentry, rate control, rhythm control, AV node, SA node, QT prolongation, torsades de pointes, post-MI arrhythmias, structural heart disease, supraventricular tachycardia, atrial fibrillation, atrial flutter, ventricular tachycardia, ventricular fibrillation, ACLS, catecholamines, cAMP, PKA, beta-1 receptors, calcium influx, nodal blockade, non-dihydropyridine vs dihydropyridine, Disopyramide, Quinidine, Procainamide, Lidocaine, Mexiletine, Flecainide, Propafenone, Metoprolol, Atenolol, Bisoprolol, Betaxolol, Esmolol, Acebutolol, Propranolol, Carvedilol, Labetalol, Nadolol, Pindolol, Timolol, Sotalol, Amiodarone, Dronedarone, Ibutilide, Dofetilide, Verapamil, Diltiazem, Amlodipine, Nifedipine, Nicardipine, Amiodarone adverse effects, blue-gray skin discoloration, interstitial lung disease, thyroid dysfunction, corneal microdeposits, hepatotoxicity, beta-blocker contraindications, asthma caution, bradycardia, AV block, cardiogenic shock, diabetes caution, CCB adverse effects, constipation, AV block, bradycardia.Become a supporter of this podcast: https://www.spreaker.com/podcast/cram-the-pance--5520744/support.

Ein bisschen Kopfschmerzen? Von wegen! Was mit Migräne mit einer elektrischen Welle zu tun hat und wie das Migräne-Gehirn generell anders tickt, darum geht es in dieser Folge mit Bent Freiwald. Teste jetzt das Thalia Hörbuch Abo 60 Tage lang gratis! Klick einfach hier: http://thalia.de/Brain60Hier geht's zum gleichnamigen Newsletter: Das Leben des BrainSchreibt uns Feedback an: brain@acbstories.comLinks zu Quellen und verwendeten Studien:1. Migraine pathophysiology: Anatomy of the trigeminovascular pathway and associated neurological symptoms, cortical spreading depression, sensitization, and modulation of pain2. Migraine: Calcium Channels and Glia3. Das Hirn des Migränepatienten - Besonderheiten im Leistungsverhalten4. Pathophysiology of Migraine Hosted on Acast. See acast.com/privacy for more information.

a focus on its acute presentations and the care we can deliver to improve outcomes for our patients. Sickle cell disease (SCD) is a lifelong inherited blood disorder that affects over 15,000 people in the UK, and millions worldwide. It's caused by the production of abnormal haemoglobin molecules, which distort red blood cells into a crescent, or “sickle,” shape. These rigid cells can block small blood vessels, leading to painful vaso-occlusive crises and organ damage. While the condition has long been most prevalent in parts of Africa, the Middle East, the Mediterranean and India, today it's a global health issue, and one we encounter regularly in UK emergency care. Tragically, failings in care have too often led to avoidable harm. The 2021 parliamentary report “No One's Listening” laid bare some of these cases, highlighting missed opportunities, poor awareness, and systemic issues that cost lives, such as the death of Evan Nathan Smith. So why are we revisiting this now? In 2024, RCEM published new Best Practice Guidelines on managing sickle cell disease in the ED. These provide clear, evidence-based standards for recognition, triage, analgesia, infection control, and safe discharge. In this episode, we take you through the key elements; Pathophysiology – how a genetic mutation drives sickling, vaso-occlusion and inflammation. Clinical presentations – from painful crises and acute chest syndrome, to stroke, anaemia, infection, priapism and pregnancy-related complications. Recognition and triage – why timely pain control within 30 minutes is a must, and how to spot red flags. Investigations and treatment – including the role of reticulocytes, the importance of knowing a patient's baseline haemoglobin, and principles of analgesia, transfusion, oxygen, and supportive care. Discharge and ongoing care – ensuring safe, joined-up planning, and involving haematology and specialist pathways wherever possible. The take-home message? Every sickle cell crisis is a medical emergency. We need to listen to patients, escalate early, involve haematology, and deliver care that meets the standards they deserve. Once again we'd love to hear any thoughts or feedback either on the website or via X @TheResusRoom! Simon, Rob & James

In this first deep dive episode, Gonzalo Pérez Marc joins Saranya Ravindran to explore the global burden of RSV. Learn about hospitalisation and mortality rates, myths, seasonal changes, and long-term respiratory consequences. This episode highlights the urgent need for awareness and policy action in paediatric care. Timestamps: 00:00 – Introduction 00:44 – Pérez Marc's journey into RSV research 03:14 – Why RSV is not just a ‘common cold' 05:47 – Mortality in newborns and infants 06:55 – Why is RSV still underestimated? 09:51 – The impact of climate change 12:37 – RSV and long-term lung disease 15:01 – Pathophysiology of RSV 16:08 – Debunking RSV myths

Naturopath and nutritionist, Ananda Mahony and fx Medicine ambassador Emma Sutherland deep dive into the triggers and causes of rosacea, and the intricate connection of the gut-skin axis. Ananda helps to unravel the complex nature of this progressive inflammatory condition, the causes and risk factors of rosacea, and how the gut plays a pivotal role in symptom manifestation and progression. She stresses the importance of treating holistically, both internally and topically, and how as clinicians we can help our patients in down-regulating inflammation associated with rosacea through diet and lifestyle and targeted supplementation. This podcast is full of clinical pearls to support clinicians to identify, manage, and treat rosacea using a holistic approach. COVERED IN THIS EPISODE (00:33) Welcoming Ananda Mahony (03:24) Rosacea causes and presentation (06:06) Pathophysiology of rosacea (11:05) Rosacea as a comorbidity to autoimmune conditions (12:48) Key differentials between rosacea and other skin conditions (14:50) Key age and sex related risk factors (18:25) Common medical treatments (20:12) The skin-gut axis (24:10) Rosacea and Helicobacter pylori (27:03) Holistic goals for treatment (34:56) Dietary approach to rosacea treatment (38:25) The role of probiotics in treatment (40:10) Supplemental treatment for rosacea (42:22) Clinical mistakes when treating rosacea Find today's transcript and show notes here: https://www.bioceuticals.com.au/education/podcasts/a-naturopathic-approach-to-rosacea-with-emma-sutherland-ananda-mahony Sign up for our monthly newsletter for the latest exclusive clinical tools, articles, and infographics: www.bioceuticals.com.au/signup/ DISCLAIMER: The information provided on fx Medicine is for educational and informational purposes only. The information provided is not, nor is it intended to be, a substitute for professional advice or care. Please seek the advice of a qualified health care professional in the event something you learn here raises questions or concerns regarding your health.

In this episode of the PCOS Repair Podcast, the focus is on the intricate connection between stress and hormonal balance in women with PCOS. Drawing on insights from the research article Stress: Endocrine Physiology and Pathophysiology, this discussion explores how the body's stress response is designed to protect survival, and how that same system can disrupt metabolic health, fertility, and hormone regulation when stress becomes chronic. You will learn exactly what happens inside the body when the sympathetic nervous system and HPA axis are activated, why cortisol plays such a powerful role in blood sugar regulation, and how ongoing stress magnifies PCOS root causes.The Science Behind Stress and Hormonal ImbalanceYou will discover how stress hormones like adrenaline and cortisol affect blood sugar, insulin sensitivity, and reproductive function. The episode explains how cortisol affects hormones to prepare the body for a perceived threat, whether it's physical or emotional, and why this process, when repeated too often, leads to insulin resistance. For women with PCOS, who are already predisposed to insulin imbalance, chronic stress compounds the problem by triggering more testosterone production, disrupting ovulation, increasing inflammation, and promoting weight gain, especially around the midsection.Identifying Stressors That Impact PCOSThe conversation highlights both obvious and hidden stressors that keep the stress response system activated. Even perceived stress, where the body feels threatened despite no immediate danger, can have lasting hormonal effects. You'll hear how these stressors contribute to HPA axis dysregulation, leading to symptoms like unrefreshing fatigue, cravings for sugar or salt, poor workout recovery, disrupted sleep patterns, low mood, and anxiety.Rather than relying on quick self-care fixes, this episode reframes stress management as an essential part of hormone therapy. You will learn how to build a lifestyle structure that reduces unnecessary stress and equips the body to handle inevitable challenges. Stress, a Missing Piece in PCOS HealingThe key takeaway from this episode is that the endocrine system is always listening. Whether stress is obvious or subtle, it sends chemical signals that shift the hormonal network, impacting insulin, cortisol, and reproductive hormones. For anyone struggling with stubborn PCOS symptoms despite making changes to diet and exercise, this discussion encourages a closer look at the body's perception of stress. Addressing and repairing the stress response can be a turning point in restoring hormonal balance, improving fertility, and feeling better in your body.You can take the quiz to discover your root cause hereREAD THE RESEARCH Stress: Endocrine Physiology and PathophysiologyLet's continue the conversation on Instagram! What did you find helpful in this episode and what follow-up questions do you have?The full list of Resources & References Mentioned can be found on the Episode webpage at: https://nourishedtohealthy.com/ep-162

In this second episode of the Hot Topic series on normal pressure hydrocephalus, Dr. Sara Schaefer discusses with Dr. Alfonso Fasano the pathophysiological theories behind NPH, co-pathology in this population, and controversies surrounding the disease.

Read the article here: https://journals.sagepub.com/doi/full/10.1177/30494826251330392

Join us in this episode of PT Snacks podcast as we dive into Thoracic Outlet Syndrome (TOS). This episode explores the causes, types, and diagnostic criteria of TOS. It includes an overview of provocation tests, symptom patterns, and potential treatment strategies, emphasizing the importance of ruling out other diagnoses. Additional resources and further reading options are provided for those wanting to expand their knowledge.00:00 Introduction to Thoracic Outlet Syndrome00:46 Understanding Thoracic Outlet Syndrome01:32 Types of Thoracic Outlet Syndrome02:35 Diagnosing Thoracic Outlet Syndrome03:51 Clinical Presentation and Symptoms05:06 Differential Diagnosis06:22 Physical Therapy Management08:04 When to Refer for Surgery08:53 Key Takeaways and ResourcesHock, G., Johnson, A., Barber, P., & Papa, C. (2022). Current Clinical Concepts: Rehabilitation of Thoracic Outlet Syndrome.. Journal of athletic training. https://doi.org/10.4085/1062-6050-138-22.Jones, M., Prabhakar, A., Viswanath, O., Urits, I., Green, J., Kendrick, J., Brunk, A., Eng, M., Orhurhu, V., Cornett, E., & Kaye, A. (2019). Thoracic Outlet Syndrome: A Comprehensive Review of Pathophysiology, Diagnosis, and Treatment. Pain and Therapy, 8, 5 - 18. https://doi.org/10.1007/s40122-019-0124-2.Support the showWhy PT Snacks Podcast?This podcast is your go-to for bite-sized, practical info designed for busy, overwhelmed Physical Therapists and students who want to build confidence in their foundational knowledge without sacrificing life's other priorities. Stay Connected! Never miss an episode—hit follow now! Got questions? Email me at ptsnackspodcast@gmail.com or leave feedback HERE. Join the email list HERE On Instagram? Find unique content at @dr.kasey.hankins! Need CEUs Fast?Time and resources short? Medbridge has you covered: Get over $100 off a subscription with code PTSNACKSPODCAST: Medbridge Students: Save $75 off a student subscription with code PTSNACKSPODCASTSTUDENT—a full year of unlimited access for less!(These are affiliate links, but I only recommend Medbridge because it's genuinely valuable.) Optimize Your Patient Care with Tindeq: Get 10% off with code PTSNACKS10: [Tindeq] ...

Angioedema – Recognition and Management in the ED Hosts: Maria Mulligan-Buckmiller, MD Brian Gilberti, MD https://media.blubrry.com/coreem/content.blubrry.com/coreem/Angioedema.mp3 Download Leave a Comment Tags: Airway Show Notes Definition & Pathophysiology Angioedema = localized swelling of mucous membranes and subcutaneous tissues due to increased vascular permeability. Triggers increased vascular permeability → fluid shifts into tissues. Etiologies Histamine-mediated (anaphylaxis) Associated with urticaria/hives, pruritus, and redness. Triggered by allergens (foods, insect stings, medications). Rapid onset (minutes to hours). Bradykinin-mediated Hereditary angioedema (HAE): C1 esterase inhibitor deficiency (autosomal dominant). Acquired angioedema: Associated with B-cell lymphoma, autoimmune disease, MGUS. Medication-induced: Most commonly ACE inhibitors; rarely ARBs. Typically lacks urticaria and itching. Gradual onset, can last days if untreated. Idiopathic angioedema Unknown cause; diagnosis of exclusion. Clinical Presentations Swelling Asymmetric, non-pitting, usually non-painful. May involve lips, tongue, face, extremities, GI tract. Respiratory compromise Upper airway swelling → stridor, dyspnea, sensation of throat closure. Airway obstruction is the most feared complication. Abdominal manifestations

In the second episode of our Rare Lung Diseases podcast mini-series, host Saranya Ravindran delves into the complexities of pulmonary arterial hypertension (PAH) with Neal Chaisson, Assistant Professor of Medicine at the Cleveland Clinic. Chaisson shares insights into why PAH remains under-recognised, the nuances of detection and diagnosis, and what the latest advancements mean for patients and clinicians. The discussion covers everything from early warning signs to future directions in PAH management and research.  Timestamps:   Part 1:   01:00 – What is PAH  02:34 – Risk factors  04:21 – Misdiagnoses  07:13 – Pathophysiology  10:44 – World Symposium classification 

Often, the first symptom of hypertrophic cardiomyopathy is sudden death. But sometimes, we get a warning— and that's where clinical judgment at the bedside saves lives.Today, Sarah goes over the case of her patient Ben, a 20-year-old experiencing syncope and chest pain. As his condition quickly deteriorated, the team had to carefully manage the patient before reaching a diagnosis of hypertrophic cardiomyopathy. Hear what pointed them to this diagnosis, why some standard interventions can be dangerous in HCM cases, and the critical decisions made during his treatment.Listen now for a deep dive into the pathophysiology and treatment of hypertrophic cardiomyopathy!Topics discussed in this episode:Case presentation of a young patient with chest painHow we got to the patient's diagnosis Pathophysiology of hypertrophic cardiomyopathyWhy the patient deteriorated and our treatment approachEmergency management of HCMOther types of cardiomyopathyKey takeaways for bedside nursesListen to episode 98, “Broken Heart Syndrome” aka Takotsubo Cardiomyopathy, here: https://healthpodcastnetwork.com/episodes/rapid-response-rn/98-broken-heart-syndrome-aka-takotsubo-cardiomyopathy/Mentioned in this episode:Listen to the In The Heart of Care Podcasthttps://link.cohostpodcasting.com/6598429e-e927-45b0-9b57-7dd34a09d803?d=seASyqjs7

It's time to pour yourself some pickle juice and suck on a salt tab (or is it?) as we talk exercise-associated muscle cramps (EAMCs) - one of the most complex, and common, afflictions facing athletes. Difficult to research and predict, the causes of EAMC's can be varied depending on the individual, as are the solutions to fix them. In this episode, Prof. Ross Tucker and Mike Finch break down the most common theories around causes and then discuss the best long-term, medium-term and immediate solutions (yes, there are some!) to preventing this painful condition.DiscourseJoin Discourse now, and become part of the growing community whose stories and testimonies inspired much of the content of this (and other) podcast! You do so by making a small donation here on Patreon, and then the world of sports science insight and opinion will be yours!SHOW NOTESThe cramping thread on Discourse - members onlyAn Evidence-Based Review of the Pathophysiology, Treatment, and Prevention of Exercise-Associated Muscle CrampsSimilar review on crampsStudy showing how pickle juice works fast in low doses, via a neural reflexRon Maughan paper on muscle cramps, contrasting the hydration model with the neural theoryPeople who cramp have similar sodium and other electrolyte levels to those who don't crampIf you drink more, your sodium levels drop, even if you drink an electrolyte containing drinkA paper that compares the two leading hypotheses for cramps: Hosted on Acast. See acast.com/privacy for more information.

High Yield Polycystic Ovary Syndrome (PCOS) ReviewReview for your PANCE, PANRE, Eor's, Physician Assistant exams, Medical, USMLE, Nursing Exams.Merchandise Link: https://cram-the-pance.creator-spring.com/►Paypal Donation Link: https://bit.ly/3dxmTql (Thank you!)Included in review: Pathophysiology, PCOS symptoms ,PCOS diagnosis, PCOS treatment, PCOS infertility, Rotterdam criteria, LH/FSH imbalance, Hyperandrogenism, Anovulation, Insulin resistance in PCOS, Letrozole, Clomiphene, PCOS vs NCCAH, PCOS ultrasound findings, 17-hydroxyprogesterone, PCOS and endometrial hyperplasia, Combined estrogen-progestin oral contraceptives, Medical mnemonics for examsBecome a supporter of this podcast: https://www.spreaker.com/podcast/cram-the-pance--5520744/support.

You are called to assess a pregnant woman who presents to your hospital complaining of shortness of breath. She is 36 weeks pregnant with twins and tells you she had been getting progressively short of breath over the last month but put it down to the physical effects of the twin pregnancy in her abdomen. However last night she couldn't get her breath lying flat, had to sleep sitting up on 3-4 pillows and feels that "it is much worse". On examination she has a respiratory rate of 24/min, SpO2 = 92%, HR 105/min, BP 95/45 and you can hear crepitations in both lung fields. Her initial blood tests come back showing a raised plasma BNP and a bedside ECHO is done by a helpful colleague - who says "subjectively her LV isn't contracting very well". Hi everyone, This week I sit down with Dr Faith Njue the most qualified person here in WA to discuss the rare but important disease - peripartum cardiomyopathy. (See Faith's Bio below). Join us in our wide ranging discussion which touches on the diagnostic challenges, demographics, proposed mechanisms and general principles involved in managing these complex patients. Thanks Faith for a great discussion! Dr Faith Njue - Bio Faith Njue graduated from the University of Western Australia and completed cardiology training in Perth. She undertook further subspeciality training in advanced heart failure/ heart transplantation at Fiona Stanley Hospital and the University of Ottawa Heart Institute in Canada. Thereafter, she undertook further fellowship in cardio-obstetrics at the John Radcliffe hospital in Oxford (UK). She has special interest in women's cardiovascular health, heart disease in pregnancy and heart failure. Faith runs the dedicated Western Cardiology cardio-obstetrics clinic, designed to support women at risk of or with pre-existing heart conditions, through preconception counselling, pregnancy and into the post-partum period. Cardio-obstetrics is an expanding subspecialty that focuses on prevention, early detection, and appropriate management of cardiovascular disease in pregnancy. She holds public consultant positions at Sir Charles Gairdner and Fiona Stanley hospitals. She is part of the Advanced heart Failure and Cardiac Transplant team at FSH. She is the cardiology clinical lead for High Risk pregnancy at FSH. References Anaesthesia and peripartum cardiomyopathy Chapman, K. Njue F, Rucklidge M. BJA Education, Volume 23, Issue 12, 464 - 472 Melanie Ricke-Hoch, Tobias J. Pfeffer, and Denise Hilfiker-Kleiner. Peripartumcardiomyopathy: basic mechanisms and hope for new therapies. Cardiovascular Research (2020) 116, 520–531. doi:10.1093/cvr/cvz252​ Bauersachs J, König T, van der Meer P, et al. Pathophysiology, diagnosis and management of peripartum cardiomyopathy: a position statement from the Heart Failure Association of the European Society of Cardiology Study Group on peripartum cardiomyopathy. Eur J Heart Fail. 2019 Jul;21(7):827-843. doi: 10.1002/ejhf.1493. Epub 2019 Jun 27. PMID: 31243866​ 2018 ESC Guidelines for the Management of Cardiovascular Disease During Pregnancy. European Heart Journal 2018. Vol 39;3165-3241​ Bromocriptine: Koenig T, Bauersachs J, Hilfiker-Kleiner D. Bromocriptine for the Treatment of Peripartum Cardiomyopathy. Card Fail Rev. 2018 May;4(1):46-49. doi: 10.15420/cfr.2018:2:2. PMID: 29892477; PMCID: PMC5971672 Hilfiker-Kleiner D, Haghikia A, Berliner D, Vogel-Claussen J, Schwab J, Franke A, Schwarzkopf M, Ehlermann P, Pfister R, Michels G, Westenfeld R, Stangl V, Kindermann I, Kühl U, Angermann CE, Schlitt A, Fischer D, Podewski E, Böhm M, Sliwa K, Bauersachs J. Bromocriptine for the treatment of peripartum cardiomyopathy: a multicentre randomized study. Eur Heart J. 2017 Sep 14;38(35):2671-2679. doi: 10.1093/eurheartj/ehx355. PMID: 28934837; PMCID: PMC5837241.

In this episode, host Dr. Doug Reh speaks with Dr. Josh Levy. They discuss the recently published Review Article: “Allergic Fungal Rhinosinusitis Diagnosis, Management, Associated Conditions, Pathophysiology, and Future Directions: Summary of a Multidisciplinary Workshop”. The full manuscript is available online in the International Forum of Allergy and Rhinology. Listen and subscribe for free to […]

Chronic sinusitis might be doing more than just clogging your nose–it could be clouding your brain. In this episode of Backtable ENT, Dr. Aria Jafari, an assistant professor at the University of Washington and co-director of the Neuroendocrinology Advanced Sinus and Skull-base Surgery Fellowship, discusses the connection between sinusitis and cognitive dysfunction with hosts Dr. Gopi Shah and Dr. Ashley Agan. --- SYNPOSIS Dr. Jafari shares how his interest in this field developed and details his research on the relationship between chronic rhinosinusitis (CRS) and brain function. The conversation highlights the comprehensive impact of sinus inflammation on overall health, emphasizing the importance of viewing CRS as a whole-body condition. They also discuss patient experiences, the methodologies used to assess cognitive dysfunction, potential treatments, and what's next in the research frontier.---TIMESTAMPS00:00 - Introduction 06:18 - The Impact of CRS on Quality of Life14:02 - Understanding Brain Fog and Cognitive Dysfunction24:29 - Pathophysiology and Theories of Cognitive Dysfunction27:44 - Chronic Inflammation and Cognitive Effects28:59 - Impact of Biologics on Cognitive Function31:28 - Risk Factors for Cognitive Dysfunction35:02 - Olfactory Symptoms 37:13 - Future Research and Treatment Approaches45:31 - Conclusion and Final Thoughts --- RESOURCES Dr. Aria Jafari https://www.uwmedicine.org/bios/aria-jafari

Tinnitus—the phantom ringing, buzzing, or hissing that affects millions. For those patients who suffer with this debilitating condition, it is frustrating to find any relief. For those clinicians trying to treat it, the causes are so multi-faceted, and the treatments seem to be lacking. Today we break down the physiology of hearing, what can go wrong in the auditory system, and the many potential causes of tinnitus, from noise exposure to neurological conditions. We also examine current treatment options, emerging therapies, and what the latest research says about finding relief. Whether you're a sufferer or just curious, this episode tunes into the facts behind the noise. Today on The Lab Report: 5:00 Tinnitus – what is it? 7:00 Physiology of hearing sound 10:30 Basic causes of tinnitus 13:45 Pathophysiology & mechanisms 17:45 Loud noise causing tinnitus 22:35 Presbycusis, ototoxicity, hearing loss 25:05 Root causes and treatment of tinnitus 28:00 Functional approach for clinicians Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: podcast@gdx.net. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests. See omnystudio.com/listener for privacy information.

A New Podcast from Obstetrics & Gynecology, featuring members from the Editorial Team and contributing authors, each month as they highlight the latest research and practice updates in the field. This episode features interviews with Dr. Yalda Afshar, author of “Biology and Pathophysiology of Placenta Accreta Spectrum Disorder,” and Dr. Clarel Antoine, author of “Endometrium-Free Closure Technique During Cesarean Delivery for Reducing the Risk of Niche Formation and Placenta Accreta Spectrum Disorders.”

In this episode of the PFC Podcast, Ian Wedmore, an expert in high altitude medicine, discusses the newly released Clinical Practice Guidelines (CPG) for altitude-related illnesses. The conversation covers the pathophysiology of acute mountain sickness, high altitude pulmonary edema, and high altitude cerebral edema, as well as their diagnosis and treatment protocols. Ian emphasizes the importance of understanding the symptoms, utilizing technology, and implementing prevention strategies to effectively manage altitude illnesses in military and wilderness settings.TakeawaysThe new CPG for altitude medicine is a significant advancement.Acute mountain sickness occurs when the body ascends too quickly without acclimatization.Diagnosis of altitude sickness relies heavily on symptom scoring systems.Vital signs are crucial for diagnosing high altitude pulmonary edema.Dexamethasone is essential for treating high altitude cerebral edema.Pre-exposure prophylaxis can reduce the risk of altitude sickness.Acetazolamide is the primary medication for preventing acute mountain sickness.Understanding the pathophysiology of altitude illnesses is key for treatment.Good hydration and nutrition are critical for acclimatization.Data collection through medic encounter forms will improve altitude care.Chapters00:00 Introduction to High Altitude Medicine02:51 Understanding Acute Mountain Sickness06:13 Diagnosing and Differentiating Altitude Illnesses08:56 Pathophysiology of High Altitude Pulmonary and Cerebral Edema12:04 Treatment Protocols for Altitude Illnesses15:08 Utilizing Technology in Altitude Medicine18:00 Prevention and Prophylaxis Strategies20:45 The Role of Medications in Altitude Care24:13 Future Directions in Altitude Medicine27:01 Conclusion and Key TakeawaysLink to full podcast:⁠https://creators.spotify.com/pod/show/dennis3211/episodes/Prolonged-Field-Care-Podcast-228-DImE-e32aek2⁠Thank you to Delta Development Team for in part, sponsoring this podcast.⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠deltadevteam.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠For more content, go to ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.prolongedfieldcare.org⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Consider supporting us: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠patreon.com/ProlongedFieldCareCollective⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ or ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.lobocoffeeco.com/product-page/prolonged-field-care⁠⁠

We dive into the recognition and management of blast crisis. Hosts: Sadakat Chowdhury, MD Brian Gilberti, MD https://media.blubrry.com/coreem/content.blubrry.com/coreem/Blast_Crisis.mp3 Download Leave a Comment Tags: Hematology, Oncology Show Notes Topic Overview Blast crisis is an oncologic emergency, most commonly seen in chronic myeloid leukemia (CML). Defined by: >20% blasts in peripheral blood or bone marrow. May include extramedullary blast proliferation. Without treatment, median survival is only 3–6 months. Pathophysiology & Associated Conditions Usually occurs in CML, but also in: Myeloproliferative neoplasms (MPNs) Myelodysplastic syndromes (MDS) Transition from chronic to blast phase often reflects disease progression or treatment resistance. Risk Factors 10% of CML patients progress to blast crisis. Risk increased in: Patients refractory to tyrosine kinase inhibitors (e.g., imatinib). Those with Philadelphia chromosome abnormalities. WBC >100,000, which increases risk for leukostasis. Clinical Presentation Symptoms often stem from pancytopenia and leukostasis: Anemia: fatigue, malaise. Functional neutropenia: high WBC count, but increased infection/sepsis risk. Thrombocytopenia: bleeding, bruising. Leukostasis/hyperviscosity effects by system: Neurologic: confusion, visual changes, stroke-like symptoms. Cardiopulmonary: ARDS, myocardial injury. Others: priapism, limb ischemia, bowel infarction.

Chapters 00:00 Introduction to Finger Tendons and Climbing Injuries 03:13 Understanding Finger Anatomy and Function 06:02 Common Finger Injuries in Climbers 08:53 Pathophysiology of Tenosynovitis 12:06 Rehabilitation Strategies for Finger Injuries 15:04 Comparing Tenosynovitis and Pulley Injuries 17:56 Managing Climbing Volume and Injury Prevention 25:38 Understanding Power Loss in Climbing 29:27 Tendon Adaptation Through Lifelong Loading 33:22 Rehabilitation Challenges for Climbers 35:05 The Role of Strength Training in Climbing 37:10 Tendon Adaptation Mechanisms 38:56 Controversies in Climbing Training Methods 41:07 Ultrasound in Diagnosing Climbing Injuries 42:22 Using Strain Gauges for Performance Measurement 43:53 Understanding Pulley Ruptures 45:36 Rehabilitation Techniques for Finger Tendons 47:14 Thumb Tendon Issues in Climbers 49:09 Future Directions in Climbing Research 50:07 Finding Professional Help in Climbing Rehabilitation   Takeaways Tyler Nelson has a doctorate in chiropractic and a master's in tendon research. Rock climbers often experience finger injuries due to overtraining. Finger tendons are unique in their anatomy and function compared to other tendons. Tenosynovitis is a common injury among climbers, often due to too much stress too soon. Rehabilitation for finger injuries should focus on gradual load increase and proper technique. The A2 pulley is crucial for finger movement and is often injured in climbers. Climbers need to be aware of the specific loads their fingers endure during training. Managing climbing volume is essential to prevent injuries in climbers. The tendon sheath plays a vital role in the health of finger tendons. Understanding the mechanics of finger tendons can aid in better training and injury prevention. Power loss is a key metric in understanding climbing performance. Beginners should focus on skill development rather than overloading their fingers. Body weight significantly affects the load on tendons during climbing. Lifelong loading is crucial for tendon adaptations in climbers. Climbers often underload their tendons during rehabilitation, leading to prolonged recovery. Strength training is essential for injury prevention and performance enhancement in climbing. Tendon adaptations require significant muscle load and proper joint positioning. Controversial training methods are gaining popularity, but their efficacy is debated. Ultrasound is the gold standard for diagnosing climbing injuries and assessing tendon health. There is a growing interest in climbing research, leading to better understanding and treatment of climbing-related injuries. Instagram: https://www.instagram.com/c4hp/ Website: https://www.camp4humanperformance.com Notes: https://jackedathlete.com/podcast-142-finger-tendons-with-tyler-nelson/

Hiccups- that annoying and at times, painful reflex that sneaks up on you when you least expect it, and sometimes refuses to leave. But what are they really? Is there an evolutionary reason we’ve developed this reflex? When should you be concerned? Can we prevent them? In this episode, we break down the pathophysiology of hiccups (yes, there’s real science behind it) Knowing the science of why they occur, we can separate fact from fiction on how to cure them. From medical insights to strange home remedies, we’re getting to the root of the world’s most inconvenient reflex. Today on The Lab Report: 3:45 Hiccups – the diaphragm and phrenic nerve 6:30 Pathophysiology of the hiccup and evolution of this reflex 9:30 Diet and lifestyle hiccup triggers 11:00 The rhythmic reflex arc 13:40 When should you be concerned? 15:50 Common cures – fact vs. fiction 21:25 Traditional Chinese Medicine and Charles Osborne 23:09 Take-aways for functional medicine practitioners Additional Resources: Genova Connect Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: podcast@gdx.net. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.See omnystudio.com/listener for privacy information.

Welcome back to The Resus Room! This time, we're diving into the fascinating and often overlooked world of electrical injuries. From household mishaps and workplace accidents to tasers and even lightning strikes, electrical injuries can range from minor shocks to life-threatening cardiac arrests. As always, we'll be taking you through the full spectrum of care, from first contact at the roadside to critical management in resus. And let's be honest, there's a real lack of clear guidance out there when it comes to managing these cases. So, we've done the legwork, scoured the literature, and we're here to make sense of it all. In this episode, we'll cover: Pathophysiology; how electricity interacts with the body and why not all shocks are created equal. Classification; what makes a low-voltage injury different from a high-voltage one, and why that matters. Prehospital & ED Management; who needs an ECG, who needs admission, and what to do with those tricky "seemingly fine" patients. Special cases; tasers, lightning strikes, and the unique challenges they pose. One of the big questions we'll be tackling: Does everyone who gets an electric shock need to go to hospital? We've all seen them, the patient that has a shock at work, but they feel fine. So, do they need a work-up, or can they safely go home? So, grab a coffee (or maybe a non-conductive beverage of choice), and let's get stuck in to Electrical Injuries! Once again we'd love to hear any thoughts or feedback either on the website or via X @TheResusRoom! Simon, Rob & James

In this episode of the PFC Podcast, host Dennis speaks with Eric Bauer from FlightBridge ED about the critical topic of anaphylaxis. They explore the importance of understanding anaphylaxis through real-life scenarios, the initial assessment and response required in emergency situations, and the underlying pathophysiology of allergic reactions. The conversation emphasizes the urgency of treatment protocols, particularly the use of epinephrine, and discusses advanced management strategies for patients experiencing anaphylaxis. This episode serves as an essential guide for emergency medical professionals and anyone interested in critical care. This conversation delves into advanced airway management, IV access, and medication protocols in the context of anaphylaxis treatment. The speakers discuss the importance of proactive decision-making, fluid resuscitation strategies, and the need for careful monitoring and adjustment of treatment. They also touch on Kuhn's syndrome, a condition that can complicate anaphylaxis cases, and emphasize the importance of seeking help when needed in critical care situations.TakeawaysAnaphylaxis is a lower frequency type of call in EMS.Initial assessment should focus on the patient's airway and breathing.Respiratory involvement indicates a more severe allergic reaction.Benadryl is not the first-line treatment for anaphylaxis.Epinephrine should be administered promptly in anaphylactic cases.Timing of treatment is crucial; reactions can escalate quickly.Advanced airway management may be necessary in severe cases.Patient positioning and PEEP can aid in respiratory distress.Understanding the pathophysiology of anaphylaxis is essential for effective treatment.Continuous reassessment is key in managing anaphylactic patients. Advanced airway management is crucial in critical situations.Proactive decision-making is essential in emergency care.Fluid resuscitation strategies must be tailored to the patient's condition.Medication protocols should include timely administration of epinephrine and steroids.Monitoring patient response is vital for adjusting treatment plans.Kuhn's syndrome can mimic myocardial infarction in young patients.It's important to be aware of the potential for rebound responses in anaphylaxis.Healthcare providers should be comfortable adjusting medications as needed.Telemedicine can provide valuable support in critical care situations.Continuous education and self-awareness are key in emergency medicine.Chapters00:00 Introduction to Anaphylaxis and Its Importance02:56 Understanding Anaphylaxis Through a Scenario05:50 Initial Assessment and Response to Anaphylaxis09:07 The Pathophysiology of Anaphylaxis11:51 Timing and Severity of Anaphylactic Reactions15:00 Treatment Protocols for Anaphylaxis18:11 Advanced Management Strategies in Anaphylaxis23:20 Advanced Airway Management in Critical Situations26:04 IV Access and Pressor Administration28:58 Fluid Resuscitation Strategies32:02 Medication Protocols in Anaphylaxis36:03 Monitoring and Adjusting Treatment41:27 Understanding Kuhn's Syndrome45:48 Final Thoughts on Anaphylaxis ManagementThank you to Delta Development Team for in part, sponsoring this podcast.⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠deltadevteam.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠For more content go to ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.prolongedfieldcare.org⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Consider supporting us: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠patreon.com/ProlongedFieldCareCollective⁠⁠⁠⁠⁠⁠ or ⁠⁠⁠⁠⁠⁠www.lobocoffeeco.com/product-page/prolonged-field-care

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, and complete CME information, and to apply for credit, please visit us at PeerView.com/AFJ865. CME credit will be available until March 9, 2026.Visualizing the Role of Neuroinflammation in the Pathophysiology and Management of Alzheimer's Disease In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Novo Nordisk Inc.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, and complete CME information, and to apply for credit, please visit us at PeerView.com/AFJ865. CME credit will be available until March 9, 2026.Visualizing the Role of Neuroinflammation in the Pathophysiology and Management of Alzheimer's Disease In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Novo Nordisk Inc.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, and complete CME information, and to apply for credit, please visit us at PeerView.com/AFJ865. CME credit will be available until March 9, 2026.Visualizing the Role of Neuroinflammation in the Pathophysiology and Management of Alzheimer's Disease In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Novo Nordisk Inc.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, and complete CME information, and to apply for credit, please visit us at PeerView.com/AFJ865. CME credit will be available until March 9, 2026.Visualizing the Role of Neuroinflammation in the Pathophysiology and Management of Alzheimer's Disease In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Novo Nordisk Inc.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, and complete CME information, and to apply for credit, please visit us at PeerView.com/AFJ865. CME credit will be available until March 9, 2026.Visualizing the Role of Neuroinflammation in the Pathophysiology and Management of Alzheimer's Disease In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Novo Nordisk Inc.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, and complete CME information, and to apply for credit, please visit us at PeerView.com/AFJ865. CME credit will be available until March 9, 2026.Visualizing the Role of Neuroinflammation in the Pathophysiology and Management of Alzheimer's Disease In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Novo Nordisk Inc.Disclosure information is available at the beginning of the video presentation.

This ASPEN podcast series is based on the Nutrition in Clinical Practice Supplement titled ‘Fat Malabsorption in Disease States' published in April 2024. This episode features Dr. Endashaw Omer, MD, MPH, focusing on physiology, pathophysiology, and diagnosis of fat malabsorption. This podcast series provides an in-depth look at the latest understanding of fat malabsorption in various disease states and was developed to educate clinicians on the current evidence in the management of this condition. This podcast is supported by Alcresta. Business Corporate by Alex Menco | alexmenco.net Music promoted by www.free-stock-music.com Creative Commons Attribution 3.0 Unported License creativecommons.org/licenses/by/3.0/deed.en_US March 2025

Discuss the pathophysiology of trigger points, describe the role trigger points have in musculoskeletal injury, discuss the treatment options for trigger pointsTimestamps(1:44) What are trigger points?(2:43) How are trigger points formed?(6:56) Trigger points and musculoskeletal injury(11:04) Treatment options for trigger points--ARTICLE CITATIONS used for this episode: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://atcornerds.wixsite.com/home/blog⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠AT CORNER FACEBOOK GROUP: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.facebook.com/groups/atcornerpodcast⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Instagram, Website, YouTube, and other links: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠atcornerds.wixsite.com/home/links⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠EMAIL US: atcornerds@gmail.comSAVE on ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Medbridge⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠: Use code ATCORNER to get $101 off your subscriptionMusic: Jahzzar (betterwithmusic.com) CC BY-SA—TO GET CEUs, enroll in this course: https://clinicallypressed.org/courses/Take the quiz and course evaluation and your certificate will be generated for you! We have no financial disclosures or conflict of interests.---Sandy & Randy

For his 40th birthday, a man is treating himself to his very first massage. His health history includes a few noteworthy details, one of which is a condition neither his massage therapist nor I had ever encountered before: hereditary spherocytosis. Are there any potential concerns? Possibly. Resources:  Hereditary Spherocytosis - Symptoms, Causes, Treatment | NORD (no date). Available at: https://rarediseases.org/rare-diseases/anemia-hereditary-spherocytic-hemolytic/ (Accessed: 19 February 2025). Hereditary spherocytosis: MedlinePlus Genetics (no date). Available at: https://medlineplus.gov/genetics/condition/hereditary-spherocytosis/ (Accessed: 19 February 2025). ‘Hereditary Spherocytosis: Practice Essentials, Pathophysiology, Etiology' (2023). Available at: https://emedicine.medscape.com/article/206107-overview?_gl=1*1ulm2jw*_gcl_au*NDQwNzg1MDc3LjE3MzkzMDYxNDM. (Accessed: 19 February 2025). Hereditary Spherocytosis: What It Is, Symptoms, Causes & Treatment (no date) Cleveland Clinic. Available at: https://my.clevelandclinic.org/health/diseases/23058-hereditary-spherocytosis (Accessed: 19 February 2025). Mehta, P. (no date) What Is Hereditary Spherocytosis?, WebMD. Available at: https://www.webmd.com/children/what-is-hereditary-spherocytosis (Accessed: 19 February 2025).   Host Bio:                    Ruth Werner is a former massage therapist, a writer, and an NCBTMB-approved continuing education provider. She wrote A Massage Therapist's Guide to Pathology, now in its seventh edition, which is used in massage schools worldwide. Werner is also a long-time Massage & Bodywork columnist, most notably of the Pathology Perspectives column. Werner is also ABMP's partner on Pocket Pathology, a web-based app and quick reference program that puts key information for nearly 200 common pathologies at your fingertips. Werner's books are available at www.booksofdiscovery.com. And more information about her is available at www.ruthwerner.com.                    About our Sponsors:   Anatomy Trains: www.anatomytrains.com    American Massage Conference:  https://www.massagetherapymedia.com/conferences   Anatomy Trains is a global leader in online anatomy education and also provides in-classroom certification programs for structural integration in the US, Canada, Australia, Europe, Japan, and China, as well as fresh-tissue cadaver dissection labs and weekend courses. The work of Anatomy Trains originated with founder Tom Myers, who mapped the human body into 13 myofascial meridians in his original book, currently in its fourth edition and translated into 12 languages. The principles of Anatomy Trains are used by osteopaths, physical therapists, bodyworkers, massage therapists, personal trainers, yoga, Pilates, Gyrotonics, and other body-minded manual therapists and movement professionals. Anatomy Trains inspires these practitioners to work with holistic anatomy in treating system-wide patterns to provide improved client outcomes in terms of structure and function.                      Website: anatomytrains.com                        Email: info@anatomytrains.com             Facebook: facebook.com/AnatomyTrains                       Instagram: www.instagram.com/anatomytrainsofficial   YouTube: https://www.youtube.com/channel/UC2g6TOEFrX4b-CigknssKHA     American Massage Conference   Get ready to immerse yourself in the excitement as the American Massage Conference (AMC) arrives to Disney Springs near Orlando, Florida (May 16th-18th, 2025)! With a legacy of 17 successful years in Ontario, Canada, this premier event, proudly hosted by ONE Concept Conferences and expertly produced by Massage Therapy Media (MTM), boasts a lineup of presenters from across the nation and around the globe. The American Massage Conference began in Atlanta in 2011 and has been hosted through the years in San Diego, Chicago, and Virginia Beach. The conference provides educational opportunities with engaging one-, two-, three- and four-hour class formats, networking opportunities, masterminds, MTM Talks, demonstrations, and an extensive exhibitor tradeshow.   Mark your calendars for an unforgettable experience filled with education, networking, and the celebration of massage therapy excellence! ABMP members receive a special discount to attend this in-person conference—log in to your ABMP account to access the discount code and register today. Website: https://www.massagetherapymedia.com/conferences  

We often think about exercising to stay fit as we age–but what about keeping our voices in shape? In this episode of BackTable ENT, Dr. Neel Bhatt, a laryngologist from the University of Washington in Seattle, discusses the intricacies of the aging voice with hosts Dr. Gopi Shah and Dr. Ashley Agan. --- SYNPOSIS Dr. Bhatt sheds light on the pathophysiology behind vocal fold atrophy, the role of glottic image capture, and the innovative use of the GlottIC (Glottal Image Capture) in measuring vocal fold bowing. They explore the impact of aging on the voice and swallowing, the relationship between vocal fold activity and overall health, and the benefits of voice therapy and procedural interventions in treating age-related voice changes. Overall, this episode summarizes valuable insights into maintaining vocal health as we age. --- TIMESTAMPS 00:00 - Introduction 01:33 - Understanding the Aging Voice and Clinical Presentations 10:41 - Impact of Aging Voice on Quality of Life 15:31 - Pathophysiology of Aging Voice 24:45 - Clinical Examination and Diagnosis 32:09 - Challenges in Scope Exams 39:33 - Swallow Studies: Fees vs. Video Fluoroscopy 41:16 - Management of Age-Related Voice Changes 58:27 - Maintaining Vocal Health with Age 01:01:01 - Conclusion and Contact Information --- RESOURCES Dr. Neel Bhatt https://otolaryngology.uw.edu/our-people/faculty/neel-k-bhatt-md BackTable+ for ENT https://plus.backtable.com/pages/ent Check out BackTable+ for ENT, our sponsor and new e-learning platform! https://plus.backtable.com/pages/ent

In this episode of the PFC Podcast, Dennis, Paul, and Ian discuss the critical topic of cold weather injuries, focusing on frostbite and trench foot. Ian shares his extensive experience in wilderness medicine and military contexts, providing historical insights into the impact of these injuries in warfare. The conversation covers prevention strategies, treatment protocols, and the importance of buddy checks in cold environments. Ian explains the pathophysiology of frostbite, the classification of injuries, and the role of thrombolytics in treatment. The episode concludes with a discussion on trench foot, emphasizing the need for proper foot care and hydration to prevent these injuries. Takeaways Frostbite and trench foot have significant historical military implications. Prevention is key in avoiding cold weather injuries. Buddy checks can help identify early signs of frostbite. Rapid rewarming in warm water is the best treatment for frostbite. Thrombolytics can help reduce tissue loss if administered early. Trench foot requires slow, dry rewarming and careful monitoring. Frostbite classification helps determine treatment and prognosis. Hydration and keeping feet dry are crucial for preventing trench foot. Avoid using active heat sources for rewarming frostbite. Rubbing frostbite with snow is a dangerous myth. Chapters 00:00 Introduction to Cold Weather Injuries 01:49 Historical Context of Cold Weather Injuries 03:14 Understanding Frostbite and Non-Freezing Cold Injuries 05:51 Prevention Strategies for Cold Weather Injuries 09:06 Buddy Checks and Hydration 10:58 Pathophysiology of Frostbite 14:01 Treatment Protocols for Frostbite 20:03 Evacuation Considerations for Frostbite 24:42 Assessment and Classification of Frostbite 30:25 Thrombolytics and Their Role in Treatment 36:11 Trench Foot: Understanding and Treatment 45:39 Conclusion and Key Takeaways Thank you to Delta Development Team for in part, sponsoring this podcast. ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠deltadevteam.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ For more content go to ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.prolongedfieldcare.org⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠ Consider supporting us: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠patreon.com/ProlongedFieldCareCollective⁠⁠⁠⁠⁠⁠ or ⁠⁠⁠⁠⁠⁠www.lobocoffeeco.com/product-page/prolonged-field-care

In this episode, learn from leading experts about managing preeclampsia with and without severe features. The panel will define the pathophysiology and potential for multi-organ system impact with preeclampsia; discussion to include postpartum care recommendations. 

Eileen Egan, DNP, FNP-C, BC-ADM, CDCES, FADCES joins The Huddle to share her expertise about the interplay between weight and glycemic management in people with Type 2 diabetes, the importance of meeting glycemic and weight goals early after a Type 2 diabetes diagnosis, as well as best practices for helping people stay motivated and engaged. This episode was made possible with support from Lilly, A Medicine Company. Learn more about this topic in this accompanying patient/client handout (support for the development of this handout was provided by Lilly, A Medicine Company): adces_tipsheet_early_control2.pdf References:American Diabetes Association. Obesity and weight management for the prevention and treatment of type 2 diabetes: standards of care in diabetes- 2024. Diabetes Care, 47(1): S145-S157.Center for Disease Control and Prevention. Adult overweight and obesity. https://www.cdc.gov/obesity/basics/adult-defining.htmlDCCT/EDIC study research group. Intensive Diabetes Treatment and Cardiovascular Outcomes in Type 1 Diabetes: The DCCT/EDIC Study 30-Year Follow-up. Diabetes Care. 2016;39(5):686-693. Gregg E, Jakicic J, Blackburn G, et al. Association of the magnitude of weight loss and changes in physical fitness with long-term cardiovascular disease outcomes in overweight or obese people with type 2 diabetes: a post hoc analysis of the Look AHEAD randomized clinical trial. Lancet Diabetes Endocrinol. 2016; 4(11): 913-921.Gutiérrez-Cuevas J, Santos A, Armendariz-Borunda J. Pathophysiological Molecular Mechanisms of Obesity: A Link between MAFLD and NASH with Cardiovascular Diseases. Int J Mol Sci. 2021. 27;22(21):11629.Howard BV, Ruotolo G, Robbins DC. Obesity and dyslipidemia. Endocrinol Metab Clin North Am. 2003;32(4):855-867. Jin X, et al. Pathophysiology of obesity and its associated diseases. Acta Pharm Sin B. 2023;13(6):2403-2424.  Laiteerapong N, Ham SA, Gao Y, et al. The legacy effect in type 2 diabetes: impact of early glycemic control on future complications (The Diabetes & Aging Study). Diabetes Care. 2019;42(3):416-426.Lean MEJ, Leslie WS, Barnes AC, et al. Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial.Lancet Diabetes Endocrinol. 2019;7(5):344-355.Lingvay I, Sumithran P, Cohen RV, le Roux CW. Obesity management as a primary treatment goal for type 2 diabetes: time to reframe the conversation. Lancet. 2022 Jan 22;399(10322):394-405. doi: 10.1016/S0140-6736(21)01919-X. Epub 2021 Sep 30. Erratum in: Lancet. 2022 Jan 22;399(10322):358. PMID: 34600604Rachel G. Miller, Trevor J. Orchard; Understanding Metabolic Memory: A Tale of Two Studies. Diabetes 1 March 2020; 69 (3): 291–299. https://doi.org/10.2337/db19-0514Ross, R., Neeland, I.J., Yamashita, S. et al. Waist circumference as a vital sign in clinical practice: a Consensus Statement from the IAS and ICCR Working Group on Visceral Obesity. Nat Rev Endocrinol16, 177–189 (2020). https://doi.org/10.1038/s41574-019-0310-7Thom G, McIntosh A, Messow CM, et al. Weight loss-induced increase in fasting ghrelin concentration is a predictor of weight regain: Evidence from the Diabetes Remission Clinical Trial (DiRECT). Diabetes Obes Metab. 2021;(23):711-719.Tsai AG, Bessesen DH. Obesity. Ann Intern Med. 2019;170(5):ITC33-ITC48.Wing RR, Bolin P, Brancati FL, et al. Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes. N Engl J Med. 2013;369(2):145-154.World Health Organization. Obesity. https://www.who.int/health-topics/obesity#tab=tab_1 Listen to more episodes of The Huddle at adces.org/perspectives/the-huddle-podcast.Learn more about ADCES and the many benefits of membership at adces.org/join.

We discuss the recognition and treatment of necrotizing fasciitis. Hosts: Aurnee Rahman, MD Brian Gilberti, MD https://media.blubrry.com/coreem/content.blubrry.com/coreem/Necrotizing_Fasciitis.mp3 Download Leave a Comment Tags: Critical Care, General Surgery Show Notes Table of Contents 0:00 – Introduction 0:41 – Overview 1:10 – Types of Necrotizing Fasciitis 2:21 – Pathophysiology & Risk Factors 3:16 – Clinical Presentation 4:06 – Diagnosis 5:37 – Treatment 7:09 – Prognosis and Recovery 7:37 – Take Home points Introduction Necrotizing soft tissue infections can be easily missed in routine cases of soft tissue infection. High mortality and morbidity underscore the need for vigilance. Definition A rapidly progressive, life-threatening infection of the deep soft tissues. Involves fascia and subcutaneous fat, causing fulminant tissue destruction. High mortality often due to delayed recognition and treatment. Types of Necrotizing Fasciitis Type I (Polymicrobial) Involves aerobic and anaerobic organisms (e.g., Bacteroides, Clostridium, Peptostreptococcus). Common in immunocompromised patients or those with comorbid...

A nearby house fire has brought several patients to your hospital via ambulance, where you are the sole provider on duty. These patients require urgent triage and stabilization before transfer to the regional burn center. You are very concerned about inhalation injury and are tasked with making complex clinical decisions in a high-pressure situation. What are the next steps? Join Drs. Kevin Foster, Tina Palmeri, Ryan Rihani, Tommy Tran, and Kiran Dyamenahalli as they explore the intricacies of managing smoke inhalation injury and more! Hosts: Tommy Tran, Tristar Skyline Medical Center Kiran Dyamenahalli, MGH Sumner Redstone Burn Center Kevin Foster, Arizona Burn Center Tina Palmeri, UC Davis Firefighters Burn Institute Regional Burn Center Ryan Rihani, UT Health Dunn Burn Center Tam Pham, Harborview Medical Center (Editor) Learning Objectives: Understand the etiology and common scenarios associated with inhalation injury  Understand the effect of inhalation injury on morbidity and mortality Describe indications for invasive airway management (intubation, bronchoscopy, and mechanical ventilation). Describe complications of inhalation injury and their management. References: Fournier, M., Turgeon, A. F., Doucette, S., Morrisette, M., Archambault, P., & Bouchard, N. (2016). Nebulized heparin for inhalation injury in burn patients: A systematic review and meta-analysis. Critical Care, 20(1), 1-10. https://doi.org/10.1186/s13054-016-1285-8 Norris, C., LaLonde, C., Slater, H., & Purser, D. (2005). Survival from inhalation injury. Burns, 31(7), 803-815. https://doi.org/10.1016/j.burns.2005.04.003 Li, W., Tang, X., Chen, Y., & Zhao, Z. (2021). Update on smoke inhalation injury: Pathogenesis, diagnosis, and treatment. Journal of Thoracic Disease, 13(4), 1797-1808. https://doi.org/10.21037/jtd-20-3328 Hahn, S. M., Kim, Y. H., Kim, K. H., & Lee, S. U. (2020). Advances in the diagnosis and treatment of smoke inhalation injury in burn patients. Acute and Critical Care, 35(1), 1-10. https://doi.org/10.4266/acc.2020.00175 Bittner, E. A., Shank, E., Woodson, L., & Martyn, J. A. (2015). Acute and long-term outcomes of burn injuries: A focus on inhalation injury. Clinics in Chest Medicine, 36(4), 549-560. https://doi.org/10.1016/j.ccm.2015.08.007 Romanowski, K. S., & Palmieri, T. L. (2019). Inhalation injury in burns: Pathophysiology, diagnosis, and treatment. Journal of Burn Care & Research, 40(5), 517-523. https://doi.org/10.1093/jbcr/irz123 Dyamenahalli, K., Garg, G., Shupp, J. W., Kuprys, P. V., Choudhry, M. A., & Kovacs, E. J. (2019). Inhalation injury: Unmet clinical needs and future research. Journal of Burn Care & Research, 40(5), 570-584. https://doi.org/10.1093/jbcr/irz055 Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more.   If you liked this episode, check out our recent episodes here: https://app.behindtheknife.org/listen

In today's episode, we explore a tragic but educational case involving a 15-year-old girl who suffered severe inhalation injury following a house fire. While heroically rescuing her brother and his friend, she endured prolonged cardiac arrest and severe multi-organ dysfunction. We'll focus on the pathophysiology, investigation, and management of inhalation injuries, including the critical role of recognizing carbon monoxide and cyanide poisoning in these complex cases.Key Learning Points:Exposure to house fire and prolonged cardiac arrestSigns of inhalation injury and airway compromisePathophysiology of inhalation injuries and their impact on multiple organ systemsManagement strategies for inhalation injury, including airway protection and ventilationDifferentiating carbon monoxide and cyanide poisoning in pediatric fire victimsCase PresentationA 15-year-old previously healthy girl is brought to the Pediatric Intensive Care Unit (PICU) after experiencing cardiac arrest during a house fire. She was found unconscious by firefighters after a heroic rescue attempt where she saved her brother and his friend. Upon arrival at the hospital, she was unresponsive, intubated, and in severe cardiovascular distress with signs of multi-organ dysfunction.Key findings include:Soot deposits and superficial burns on extremitiesProlonged resuscitation (45 minutes of field CPR and 47 minutes of in-hospital CPR)Cardiovascular compromise with PVCs, cool extremities, and delayed capillary refillMetabolic acidosis, AKI, coagulopathy, transaminitisSevere hypoxic-ischemic encephalopathy on EEGThese findings raise immediate concern for inhalation injury, which is the primary focus of today's discussion.Pathophysiology of Inhalation InjuryWhen a patient is exposed to smoke and hot gases during a fire, inhalation injury results in significant damage to the respiratory system. Inhalation injury has three main components:Upper airway involvement – Thermal injury can cause swelling and obstruction.Chemical pneumonitis – Noxious chemicals like carbon monoxide and cyanide trigger inflammation in the lungs.

The brain's ability to recover after trauma is astonishing—and often overlooked in conventional care. In this episode of New Frontiers in Functional Medicine, I sit down with Dr. David Musnick, a long-time friend and brilliant clinician, to explore how we can unlock the brain's full potential for healing. Dr. Musnick challenges the standard of care for traumatic brain injuries and post-concussion syndrome, introducing a functional medicine approach that integrates advanced tools like Frequency-Specific Microcurrent, targeted nutritional strategies, and personalized interventions. His insights into the stages of recovery, the importance of addressing neuroinflammation, and the role of the gut-brain connection were a true "aha" for me. We also dive into groundbreaking methods for reversing secondary brain damage, a concept that could change everything for patients and practitioners alike. This conversation is packed with actionable takeaways and hope for those navigating brain injuries, cognitive impairment, or persistent post-concussion symptoms. You don't want to miss it.~DrKF Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast for the full list of links and resources. GUEST DETAILS David Musnick MD FMI Center for Optimal Health http://www.fmioptimal.com http://www.peakmedicine.com Clinic: (208)609-9130 David Musnick MD is a Sports Medicine and Functional Medicine MD who practices in Eagle Idaho and Bellevue WA. In 2016 he developed the first program to heal the brain after Concussion based on the Pathophysiology mechanisms that go on after a Concussion and TBI. He has healed hundreds of patients and is published on his approach in the book Integrative Neurology. In his practice he defines the brain areas that have been injured and develops a detailed approach to healing these areas. His approach integrates food choices, supplements, sleep, exercise, EMF protection, HBOT and Frequency Specific Microcurrent. He has expanded his approach to also treat Cognitive Impairment and other Neurological disorders such as MS and Parkinson's. He sees patients in both Idaho and Washington but can see patients from other states on Telemedicine via a Peer to Peer consultation. THANK YOU TO OUR SPONSORS DIAMOND Precision Analytical: https://tinyurl.com/4anbz7b3 Biotics Research: https://www.bioticsresearch.com/ Integrative Therapeutics: https://tinyurl.com/4emwj48z GOLD OneSkin: https://tinyurl.com/ycxtw4zt TimeLine Nutrition:: https://tinyurl.com/bdzx2xms MIDROLL OneSkin: https://tinyurl.com/ycxtw4zt DUTCH https://dutchtest.com/ CONNECT WITH DrKF Want more? Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz YouTube: https://tinyurl.com/hjpc8daz Instagram: https://www.instagram.com/drkarafitzgerald/ Facebook: https://www.facebook.com/DrKaraFitzgerald/ DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb Younger You Group Program: https://tinyurl.com/4hvusavw Younger You book: https://tinyurl.com/mr4d9tym Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfw

CardioNerds (Dr. Dan Ambinder and Dr. Rick Ferraro) join Dr. Mansi Oberoi and Dr. Mohan Gudiwada from the University of Nebraska Medical Center discuss a case of constrictive pericarditis. Expert commentary is provided by Dr. Adam Burdorf, who serves as the Program Director for the Cardiovascular Medicine Fellowship at the University of Nebraska Medical Center. The case discussed involves a 76-year-old woman with a history of monoclonal gammopathy of undetermined significance, chronic obstructive pulmonary disease, type 2 diabetes mellitus, and squamous cell carcinoma was admitted to the hospital for worsening shortness of breath, swelling in lower extremities, hyponatremia, and urinary tract infection. CT chest to evaluate for pulmonary embolism showed incidental pericardial calcifications; the heart failure team was consulted for the management of her decompensated heart failure. Echo images were nondiagnostic. Subsequent invasive hemodynamic monitoring showed elevated right and left-sided filling pressures, diastolic equalization of LV and RV pressures, and positive RV square root sign with ventricular interdependence. Cardiac MRI showed septal flattening on deep inspiration and septal bounce, suggestive of interventricular dependence. After a heart team discussion and with shared-decision making the patient opted for medical management owing to her comorbidities and frailty. Enjoy this 2024 JACC State-of-the-Art Review to learn more about pericardial diseases and best practices for pericardiectomy (Al-Kazac et al., JACC 2024) US Cardiology Review is now the official journal of CardioNerds! Submit your manuscript here. CardioNerds Case Reports PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Case Media - Constrictive Pericarditis Echo: Left Ventricular ejection fraction = 55-60%. Unclear septal motion in the setting of atrial fibrillation MRI: Diastolic septal flattening with deep inspiration as well as a septal bounce suggestive of interventricular dependence and constrictive physiology  References Garcia, M. Constrictive Pericarditis Versus Restrictive Cardiomyopathy. Journal of the American College of Cardiology, vol. 67, no. 17, 2016, pp. 2061–2076. Pathophysiology and Diagnosis of Constrictive Pericarditis. American College of Cardiology, 2017. Geske, J., Anavekar, N., Nishimura, R., et al. Differentiation of Constriction and Restriction: Complex Cardiovascular Hemodynamics. Journal of the American College of Cardiology, vol. 68, no. 21, 2016, pp. 2329–2347. Constrictive Pericarditis. ScienceDirect. Constrictive Pericarditis. Journal of the American College of Cardiology, vol. 83, no. 12, 2024, pp. 1500-1512.