ImmunoCAST

Dive into the fascinating world of allergen components and how modifying them is revolutionizing food safety for allergy sufferers. We explore the unexpected ways allergen components affect food allergenicity, and how this knowledge is being leveraged to create safer options. From alpha-Gal-free pigs to ovomucoid-free eggs, we discuss groundbreaking developments in modified foods. We also cover the latest research on reducing allergenicity in peanuts, wheat, and even pet dander. Learn how clinically understanding specific allergen components can dramatically improve your ability to diagnose and manage food allergies, potentially allowing patients to safely consume foods they previously had to avoid. References and resources available here: https://www.thermofisher.com/phadia/us/en/resources/immunocast/reshaping-food-allergy-safety-with-allergen-components.html

Did you know that urban planners inadvertently created allergy hotspots by favoring male trees in city landscapes? This episode of ImmunoCAST takes listeners on a cross-country journey, exploring how allergies manifest differently across various US regions. We address the challenge of identifying and managing region-specific allergens, from urban environments to coastal areas and the heartland. Topics covered include the impact of imported fire ants in the Southeast, the prevalence of dust mites in humid climates, and the surprising connection between birch trees and peanut allergies in the Northeast. We also delve into the emerging concern of cannabis allergies in the Midwest and the unique "cedar fever" phenomenon in the Southwest. The episode concludes with practical insights on diagnostic approaches and the importance of considering both allergic and non-allergic triggers in patient evaluations. Episode references and resources available here: https://www.thermofisher.com/phadia/us/en/resources/immunocast/allergy-triggers-treatments-across-america.html

Did you know the average person unknowingly consumes about 2 pounds of insects or insect parts annually? This startling fact underscores the ubiquitous presence of insects in our environment and diet, presenting unique challenges in allergy diagnosis and patient management. This episode of ImmunoCAST explores the multifaceted world of insect-related allergies, moving beyond common respiratory or stinging triggers to uncover lesser-known presentations. We explore the "Pancake Syndrome" and its link to dust mites, discuss the cross-reactivity between dust mites and shellfish, and examine the allergenic potential of insect-derived food additives. By understanding these complex interactions, clinicians can enhance their diagnostic acumen and provide more comprehensive care for patients with suspected insect allergies. References and resources available at: https://www.thermofisher.com/phadia/us/en/resources/immunocast/hidden-insect-allergies-food-dust-mites.html?cid=0ct_3pc_05032024_9SGOV4

Many of the 33 million Americans affected by food allergies, start their allergy care journey with a visit to their primary care or family medicine clinician. Tune in as Dr. Ruchi Gupta, a board-certified pediatrician and founding director of the Center for Food Allergy and Asthma Research (CFAAR), shares key insights on the current state of food allergies in America as well as impactful diagnostic and management tips that every primary clinician should consider when seeing patients with food allergies.

In this episode of ImmunoCAST, we share an example of impactful patient education from our friends at Allergy Insider (@allergyinsider). They hosted Dr. Zachary Rubin (@rubin_allergy), a double board-certified pediatrician and allergist and internet sensation, and ImmunoCAST's own Gary Falcetano, PA, on their recent Instagram Live segment “Ask the Insider” to discuss the allergy symptom threshold.Because Allergy Insider aims to provide patients with evidence-based, educational information about their allergic conditions, helping them feel more empowered and informed about their health, Allergy Insider is a perfect source to refer your patients to if they want to learn more about their allergic conditions. Tune in and discover some helpful tips you can share with your patients when discussing reducing exposure to their allergic triggers.Episode resources and references available at https://www.thermofisher.com/phadia/us/en/resources/immunocast/understanding-allergy-symptom-threshold-dr-zachary-rubin.html?cid=0ct_3pc_05032024_9SGOV4

This spring, patients may be reporting that some foods cause their mouth to itch. Is this a food allergy? Or is this pollen food allergy syndrome (PFAS)? In this episode of ImmunoCAST tackles the clinical challenge of distinguishing this condition from more severe food allergies. We explore the mechanisms behind PFAS, its relationship to seasonal allergies, and the importance of comprehensive allergy evaluation. Key topics include the role of specific IgE testing, differentiating between true food allergies and cross-reactivity with pollen, and management strategies such as avoiding trigger foods and processing methods to denature allergens. Gain valuable insights into improving patient outcomes through accurate diagnosis and tailored management plans. Episode resources and references available at https://www.thermofisher.com/phadia/us/en/resources/immunocast/%20pollen-food-allergy-syndrome-ige-testing-cross-reactivity.html?cid=0ct_3pc_05032024_9SGOV4

In partnership with Food Allergy Research & Education (FARE), Gary Falcetano discusses the unique challenges of diagnosing and managing Alpha-gal syndrome (AGS), a red meat allergy triggered by tick bites with Dr. Scott Commins, a leading expert in Alpha-gal syndrome (AGS) and distinguished professor at the university of North Carolina. They explore the distinct nature of Alpha-gal as a carbohydrate allergen, the prolonged journey to diagnosis, and the syndrome's expanding geographic prevalence. Key topics include the delayed onset of symptoms, the role of fatty meats in severe reactions, and the presence of Alpha-gal in medications. Gain valuable insights into effective management strategies and future treatment possibilities, equipping healthcare providers with the knowledge to better support patients with AGS. Episode resources and references available at: https://www.thermofisher.com/phadia/us/en/resources/mmunoCAST/alpha-gal-syndrome-tick-season-dr-scott-commins.html?cid=0ct_3pc_05032024_9SGOV4

Coming out of the winter months and flu season, we dive into the best ways to help prepare patients with asthma for the spring allergy season. From insights into the impact of allergies and viral illnesses on patients with asthma to ways to help reduce exposure to potential allergic triggers, tune in and gain important information on how you can help optimize patient outcomes going into spring. Episode resources and references available at https://www.thermofisher.com/phadia/us/en/resources/immunocast/preparing-patients-with-asthma-for-spring-allergy-season.html?cid=0ct_3pc_05032024_9SGOV4

Dr. David Golden is a member of the Joint Task Force on Practice Parameters and has directed research programs on insect allergy and anaphylaxis at Johns Hopkins for 30 years, publishing numerous research and review articles. In this episode we speak with Dr. Golden about the latest updates to the anaphylaxis practice parameters, emphasizing critical changes in recommendations around the role of epinephrine and more. Transitioning to stinging insect venom allergy, we discuss the effectiveness of venom immunotherapy, the role of testing with allergen components in tailoring treatment, and the impact of risk stratification on patient quality of life. Gain valuable insights into diagnostic strategies and management techniques that can enhance patient care and reduce fear associated with insect sting allergies. Episode resources and references available at https://www.thermofisher.com/phadia/us/en/resources/immunocast/doctor-david-golden-and-latest-anaphylaxis-guideline-updates.html?cid=0ct_3pc_05032024_9SGOV4

This is part 2 of ImmunoCAST, highlighting interesting abstracts presented at the American College of Allergy, Asthma, and Immunology's 2024 meeting. In this episode, we explore nine allergy-related medical case studies that were showcased and piqued our interest. Tune in and discover some of the fascinating ways allergies may present in your patients and what you can do to optimize your diagnosis and management. From shrimp exposure through breast milk to developing a peanut sensitization from a blood transfusion, you're not going to want to miss this episode. Episode resources and references available at: https://www.thermofisher.com/phadia/us/en/resources/immunocast/s2e13.html?cid=0ct_3pc_05032024_9SGOV4

ImmunoCAST visited the 2024 American College of Allergy, Asthma, and Immunology meeting and collected some of the most interesting and important research papers which were unveiled during the conference. Whether you're an allergist or a primary care clinician, tune in to hear some of the most exciting research and insights that are coming out of the field of allergy, including the role of climate change on latex allergy, the role of allergic rhinitis and food allergy on mental health, and much more. Episode resources and references available at https://www.thermofisher.com/phadia/us/en/resources/immunocast/s2e12.html?cid=0ct_3pc_05032024_9SGOV4

With almost half a million followers on Instagram and over 1.3 million followers on TikTok, allergist Dr. Zachary Rubin has built a huge following of users interested in his allergy insights. Tune in as we interview Dr. Rubin to understand the role of a clinician online, best practices for combating online misconceptions, and how he leverages digital platforms to deliver accurate allergy and immunology education. We also get advice on potential ways primary care providers can help optimize allergy care before specialist referrals, as well as some of the pitfalls they should avoid when managing patients with allergies. From social media tips to optimizing your practice, you're not going to want to miss this episode. Episode resources and references available at https://www.thermofisher.com/phadia/us/en/resources/immunocast/s2e11.html?cid=0ct_3pc_05032024_9SGOV4

Because ethanol is too small of a molecule for the body to make antibodies to, there really is no such thing as an "alcohol allergy," but that doesn't mean patients can't have a reaction to substances found within alcohol. In this episode of ImmunoCAST, we address the clinical challenge of distinguishing between alcohol intolerance and true allergy. Tune in as we explore histamine intolerance, sulfite sensitivity, and ALDH2 deficiency, as well as hidden allergens in alcoholic beverages, the role of alcohol as a cofactor in allergic reactions, and specific allergens found in wine and beer. Discover how to diagnose and manage alcohol-related reactions by learning more about the importance of detailed patient history, specific IgE testing, and the implications of enzyme deficiencies. Episode resources and references available at https://www.thermofisher.com/phadia/us/en/resources/immunocast/s2e10.html?cid=0ct_3pc_05032024_9SGOV4

Halloween presents unique challenges for clinicians managing patients with food allergies. In this episode, to heighten awareness and preparedness, we explore the emotional impact on children with food allergies, who may often feel excluded from Halloween activities, as well as emphasize the importance of an accurate diagnosis using component resolved diagnostic blood tests to help identify exactly what with in an allergen may be causing a reaction. Additionally, we explore strategies for clinicians to help balance safety with inclusion, ensuring that children with food allergies can participate in Halloween festivities without compromising their health. Episode resources and references available at https://www.thermofisher.com/phadia/us/en/resources/immunocast/s2e8.html?cid=0ct_3pc_05032024_9SGOV4

When we picture a patient struggling with respiratory allergies, our mind might immediately jump to spring allergy season. However, fall allergies, while often overlooked, can cause patients to experience reactions just as severe due to the combination of outdoor triggers and viral season. Tune in as we discuss the history of ragweed, its impact on public health, and its connection to oral allergy syndrome. We also dive into the role of outdoor mold as leaves decompose, the impact of flu season, and the importance of managing indoor allergens such as pet dander and dust mites. Listen now and gain helpful tips on how to diagnose, prepare for, and manage patients this fall season. Link to episode resources and references: https://www.thermofisher.com/phadia/us/en/resources/immunocast/s2e8.html?cid=0ct_3pc_05032024_9SGOV4 **Clarification: At 2m12s, the ragweed epidemic Gary is referencing occurred in the 20th century, not the 19th century.

ImmunoCAST welcomes Dr. Michael Benninger, Professor and Former Chair of the Department of Otolaryngology-Head and Neck Surgery in the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, as a guest expert speaker on this special Allergy After Dark episode. With over 200 publications, Dr. Benninger is an expert on respiratory allergies and their impact on sexual function in patients. Tune in to this episode, where Dr. Benninger joins Gary and Luke to discuss the importance of understanding a patient's allergic triggers and how they may impact a more intimate side of their life. Episode resources and references available at https://www.thermofisher.com/phadia/us/en/resources/immunocast/s2e7.html

Does your patient have a food allergy or intolerance? Celiac disease or wheat allergy? When it comes intolerances vs. allergies, there's a lot of symptoms overlap. In this episode of ImmunoCAST, we discuss the mechanisms and differences behind IgE-mediated food allergies, autoimmune conditions like celiac disease, and various types of food intolerances, including metabolic, pharmacologic, and toxic reactions. We also dive into the pitfalls of at-home IgG food intolerance tests that patients may use as well as the importance of clinical history and proper diagnostic testing. Tune in for valuable insights to help optimize your diagnosis and patient management of adverse food reactions. Episode resources and references available at https://www.thermofisher.com/phadia/us/en/resources/immunocast/s2e6.html?cid=0ct_3pc_05032024_9SGOV4

Using the Triple Aim framework to dissect the current status of allergy care in America, this episode delves into the per capita cost, population health, and patient experience of care, emphasizing the importance of accurate diagnosis and appropriate referrals. Tune in for insights on improving healthcare efficiency, reducing costs, and enhancing patient outcomes. Don't miss this informative episode designed to help clinicians better serve their patients. Episode resources and references available at https://www.thermofisher.com/phadia/us/en/resources/immunocast/s2e5.html?cid=0ct_3pc_05032024_9SGOV4

Asthma Peak Week is nearly a month away, giving clinicians just enough time to start to help prepare their at-risk patients. Tune into this episode of ImmunoCAST where we break down why in September there is a spike in asthma exacerbations and hospitalizations as well as some tips and insights on how to ensure your patients with asthma are prepared and safe in the coming month. Episode resources and references available at https://www.thermofisher.com/phadia/us/en/resources/immunocast/s2e4.html?cid=0ct_3pc_05032024_9SGOV4

This episode covers some of the more popular theories on ways patients may develop allergies, such as the epithelial barrier hypothesis, hygiene hypothesis, and microbiome theory. From children to older adults, Gary and Luke discuss the prevalence of food and respiratory allergies and how these allergies may present and change over the course of a patient's life. Tune in to understand how these changes may impact past diagnoses as well as patient management. Episode resources and references available at https://www.thermofisher.com/phadia/us/en/resources/immunocast/s2e3.html?cid=0ct_3pc_05032024_9SGOV4

Whether your patients are Olympians, little league champs, or rec center pros, tune in to discover the fascinating impact that food and respiratory allergies have on athletes. In this episode of ImmunoCAST, Gary and Luke delve into key insights on diagnosing and managing allergies in athletic patients, from examining the prevalence of allergic diseases among Olympians and recreational athletes to unpacking conditions like exercise-induced anaphylaxis. Episode resources and references available at: https://www.thermofisher.com/phadia/us/en/resources/immunocast/s2e2.html?cid=0ct_3pc_05032024_9SGOV4

In this episode of ImmunoCAST, hosts Gary and Luke break down the essentials of tree nut allergen components, focusing on hazelnut, cashew, walnut, and Brazil nut. They highlight the significant prevalence of tree nut allergies and the importance of accurate diagnosis using component-resolved diagnostics. The discussion covers different types of allergen components, such as PR-10 proteins, lipid transfer proteins, and storage proteins, and what they mean for patient care. This episode is designed to help primary care clinicians better understand how to predict the severity of allergic reactions and make informed decisions in managing their patients. An interpretation guide and lab ordering information are also provided to make it easy to apply these insights in practice. Episode resources and references available at: https://www.thermofisher.com/phadia/us/en/resources/immunocast/s2e1.html?cid=0ct_3pc_05032024_9SGOV4

How can primary care clinicians optimize the diagnosis and treatment of stinging insect allergies? Tune into this episode of ImmunoCAST and hear a discussion around allergies to bee, wasp, and fire ant venoms. You'll learn how testing with allergen components can aid in reaching an accurate diagnosis, the significance of tryptase levels in forecasting severe allergic reactions, as well as how impactful immunotherapy may be when conducted based on accurate diagnostic testing. Episode resources and references available at [LINK TO EPISODE PAGE]

More allergenic peanuts? Fungi in crops that may make patients more susceptible to food allergy sensitization? And what does the epithelial barrier hypothesis have to do with all of it? Tune into this newsroom episode of ImmunoCAST as we discuss a recently published review paper by Ashley Sang Eun Lee, MD, and Nicole Ramsey, MD, PhD, from the Icahn School of Medicine at Mount Sinai which presents some of the interesting ways that climate change may impact patients with food allergies. Episode resources and references available at https://www.thermofisher.com/phadia/us/en/resources/immunocast/s1e12.html?cid=0ct_3pc_05032024_9SGOV4

Ever since the CDC released its Morbidity and Mortality Weekly report about alpha-Gal syndrome (AGS) last summer, it seems that everyone is talking about this odd allergy to red meat. Whether you're an allergist or a primary care clinician, get the clinical facts about AGS in this episode of ImmunoCAST where we explore the syndrome's origins and discovery, what potential foods (some perhaps lesser known) and medical products may cause reactions, and the most effective way to diagnose and treat patients. Episode resources and references available at [LINK TO EPISODE PAGE]

Can patients tolerate baked forms of egg and milk? Is it a clinical peanut allergy or cross-reactivity with pollen? In this episode of ImmunoCAST, Gary and Luke dive into food allergen components and their impact on patient management. Their discussion covers specific proteins found in eggs, milk, peanuts, and tree nuts and what it means for patients who are sensitized to them. They also discuss the role of allergen component diagnostics, how it can provide clarity, and aid in appropriate patient care decisions. Episode resources and references available at https://www.thermofisher.com/phadia/us/en/resources/immunocast/s1e10.html?cid=0ct_3pc_05032024_9SGOV4

In this episode of ImmunoCAST, listen to a discussion around cannabis allergy and the importance of healthcare providers recognizing and inquiring about its exposure, especially in patients with asthma or food allergies. Gary and Luke delve into the history, routes of exposure, and the identification of specific allergens within cannabis, such as lipid transfer proteins, which may cross-react with other plant foods. This episode highlights the need for improved diagnostic methods and greater clinical awareness of cannabis as a potential allergen. Episode resources and references available at https://www.thermofisher.com/phadia/us/en/resources/immunocast/s1e9.html?cid=0ct_3pc_05032024_9SGOV4

In this episode of ImmunoCAST, Gary and Luke explore the new European Academy of Allergy and Clinical Immunology (EAACI) food allergy diagnosis guidelines. They break down some of the significant recommendations found within these guidelines, such as important questions clinicians should ask during a structured food allergy history, the role of diagnostic testing, and the use of testing with allergen components in a diagnosis. Episode resources and references available at https://www.thermofisher.com/phadia/us/en/resources/immunocast/s1e8.html?cid=0ct_3pc_05032024_9SGOV4

Is it really allergies causing patients' rhinitis symptoms this spring or is it something nonallergic? Sure, pollen is out and about, but that doesn't mean that those nonallergic triggers simply disappear when allergy season starts. Listen in as Gary and Luke discuss the different types of nonallergic rhinitis, potential triggers, and how healthcare providers can help provide clarity this allergy season when allergy medication isn't working, and symptoms aren't easing up. Episode resources and references available at https://www.thermofisher.com/phadia/us/en/resources/immunocast/s1e7.html?cid=0ct_3pc_05032024_9SGOV4

Allergic asthma can be triggered by pollen, dust mites, pets... and thunderstorms? It's not uncommon for clinicians to see patients with respiratory allergies who also suffer from allergic asthma. Join Gary and Luke as they discuss allergic asthma as well as important clinical information, such as practice parameters and guidelines, which may help healthcare providers optimize their patient management. Episode Resources and references available at https://www.thermofisher.com/phadia/us/en/resources/immunocast/s1e6.html?cid=0ct_3pc_05032024_9SGOV4

Can a patient tolerate a male or female dog? Are they cross reacting with any other pet species? What is their risk of developing asthma? All these questions and more can be answered with the help of the next evolution of pet allergy testing: pet component resolved diagnostics. Join Gary and Luke as they dive into what allergen components are, how they can help optimize pet allergy patient care, and some of the interesting information they may provide to you and your practice. Episode Resources and references available at https://www.thermofisher.com/phadia/us/en/resources/immunocast/s1e5.html?cid=0ct_3pc_05032024_9SGOV4

Educating patients with food allergies often entails conversations around checking food labels, informing restaurant staff, and general allergen avoidance, however, for those patients who are sexually active it may be a good idea to have "the talk" about potential risks they may face if they engage in intimate relations. From allergens being passed from kissing to how some allergenic molecule may cross into a partner's seminal fluid, Gary and Luke review four cases in which food allergy reactions arose due to intimacies. Episode resources and references available at https://www.thermofisher.com/phadia/us/en/resources/immunocast/s1e4.html

There's no denying that the news, online trends, and social media may all impact how a patient perceives and understands their allergies and allergy symptoms. From increased awareness around alpha-Gal syndrome to social media ads advocating for patients to purchase allergy-related products, this relationship between patients and online media can be helpful, but sometimes counterproductive, when it comes to clinicians managing a disease. Gary and Luke discuss the impact of allergy news media and how healthcare providers can help educate patients on viral or "trending" allergy topics. Episode resources and references available at https://www.thermofisher.com/phadia/us/en/resources/immunocast/s1e3.html

It can be difficult for patients to manage their symptoms when they are surrounded by an allergen that is difficult to control, such as pollen. Gary and Luke dive into exactly what the allergy symptom threshold is and how understanding its relationship to allergen exposure reduction may aid clinicians in helping patients with allergies find relief. Episode Resources and references available at https://www.thermofisher.com/phadia/us/en/resources/immunocast/s1e2.html

From the history of allergy testing to important guidelines, Gary and Luke discuss the nuances of specific IgE testing that every primary care healthcare provider should consider when managing patients with suspected allergic conditions. Episode resources and references available at https://www.thermofisher.com/phadia/us/en/resources/immunocast/s1e1.html

From medical guidelines and best practices to educational insights on specific disease states, ImmunoCAST is a podcast dedicated to providing healthcare providers of all specialties clinically relevant, easy-to-digest episodes on allergy related topics.