Podcasts about Gupta

Institute of Policy Studies

Play Episode Listen Later Dec 18, 2025 72:43

Jason Kander and Ravi Gupta break down the Republican revolt that forced a vote on extending Obamacare subsidies, as four GOP lawmakers joined Democrats on a discharge petition to prevent premiums from doubling for millions of Americans. They analyze the political fallout for House Republicans in swing districts, Speaker Mike Johnson's failed negotiations, and the looming deadline that could leave 22 million people facing higher health care costs. Kander and Gupta also dive into a wave of national turmoil, from mass shootings and rising antisemitism among young Americans to chaos and incompetence inside Trump's law enforcement leadership and explosive reactions to Trump's own rhetoric. Plus, they discuss new reporting on Susie Wiles, deepening MAGA infighting, growing backlash to AI and Big Tech, and fresh polling showing cracks in Trump's base. This and more on the podcast that helps you, the majority of Americans who believe in progress, convince your conservative friends and family to join us—this is Majority 54! Aura Frames: Exclusive $35 off Carver Mat at https://on.auraframes.com/MAJORITY54 Promo Code MAJORITY54 Dupe: For a limited time, the first 10,000 people who go to https://Dupe.com/majority will instantly get 500 Dupe Points IndaCloud: If you're 21 or older, get 25% OFF your first order + free shipping @IndaCloud with code MAJORITY at https://inda.shop/MAJORITY! #indacloudpod Subscribe to Ravi's Substack: https://realravigupta.substack.com/ For more information visit: https://www.ravimgupta.com/analog Majority 54 on Twitter: https://twitter.com/majority54 Jason on Twitter: https://twitter.com/JasonKander Jason on Instagram: https://www.instagram.com/jasonkander/ Ravi on Twitter: https://twitter.com/RaviMGupta Ravi on Instagram: https://www.instagram.com/ravimgupta Ravi on Youtube: https://www.youtube.com/@LostDebate Remember to subscribe to ALL the MeidasTouch Network Podcasts: MeidasTouch: https://www.meidastouch.com/tag/meidastouch-podcast Legal AF: https://www.meidastouch.com/tag/legal-af MissTrial: https://meidasnews.com/tag/miss-trial The PoliticsGirl Podcast: https://www.meidastouch.com/tag/the-politicsgirl-podcast The Influence Continuum: https://www.meidastouch.com/tag/the-influence-continuum-with-dr-steven-hassan Learn more about your ad choices. Visit megaphone.fm/adchoices

IPS-Nathan Lecture by Mr Piyush Gupta — Lecture III

Play Episode Listen Later Dec 18, 2025 87:02

IPS-Nathan Lecture by Mr Piyush Gupta — Lecture III by Institute of Policy Studies

institute lecture gupta policy studies piyush

Kanika Chadda-Gupta On Becoming The Woman We Are Meant To Be In The Eye Of The Storm

For The Love With Jen Hatmaker Podcast

Play Episode Listen Later Dec 17, 2025 67:44

Description:Today's guest is someone who instantly made an impression on Jen when they met at a recent Hello Sunshine event in LosAngeles, when she moderated a Shine Away panel with Jen and beloved 9010 star and recent For the Love guest, Jennie Garth. Within five minutes Jen thought, “Okay… she's one of us.” Warm, sharp, steady — Kanika Chadda-Gupta has this grounding presence that makes a whole room exhale. An award-winning former CNN journalist and producer, Kanika built a thriving career in television news before motherhood rerouted her life in the most profound way. Born in India and raised in the U.S., her story is braided with themes so many of us know intimately: immigration and bicultural identity, the expectations women inherit, the invisible labor we carry, and the endless negotiation between ambition, caregiving, and our own becoming. Today, Kanika is the creator and host of the beloved Total Mom Sense podcast, where she distills her lived experience — raising children while caring for aging parents, navigating mental and emotional load, reinventing purpose in midlife — into practical wisdom for women who are doing it all and feeling all of it. In this conversation, we talk about what happens when life asks us to reevaluate our pace, our priorities, and the stories we've been handed about success. We discuss staying rooted inside seasons of huge responsibility, finding yourself in the middle of caregiving, and reclaiming a sense of agency and identity in motherhood and beyond. If you've ever felt stretched thin between generations, pulled in every direction, or unsure how to follow your own calling while caring for everyone else — Kanika's clarity and compassion will feel like a deep breath. This one's for all of us standing at the intersection of who we were, who we are, and who we're still becoming. Thought-provoking Quotes: "I like getting the gold star from all of my teachers. I did all the AP classes. I hung out with my teachers at lunchtime. We had open lunch, and it was like you could go to McDonald's, or you could go across the street to the pizza place. But I would go sit with Ms. Townsend, my biology teacher, and just kick it.” – Kanika Chadda-Gupta "It may be, the only headlights that you see heading to the eye of the storm are the first responders and the reporters. And I thought, I want to be in the eye of the storm. I belong here. I need to be here. I need to prove myself. And so then I stayed.” – Kanika Chadda-Gupta "I was most surprised by how your kids will make you face your childhood trauma head on. My dad and I get along great now, but when we were younger, he would say things that really just shot my self-esteem. And those are the first things that come up when my kids do something wrong and I'm like, wow, I gotta reframe." – Kanika Chadda-Gupta Resources Mentioned in This Episode: Hello Sunshine Shine Away Conference 2025 – https://shineaway.hello-sunshine.com/event/eddb3575-ec80-4812-a371-354c900d7cbf/summary Jim Gaffigan, comedian – https://www.jimgaffigan.com/ Mom Brain with Hilaria Baldwin and Daphne Oz - https://podcasts.apple.com/us/podcast/mom-brain/id1438292826 Guest's Links: Website - https://kanikachaddagupta.com/ Instagram - https://www.instagram.com/kanikachaddagupta/ Twitter - https://x.com/KanikaChadda Facebook - https://www.facebook.com/kanikachaddagupta/ Youtube - https://www.youtube.com/channel/UCgkOq_AmLsvu6YJsKglQvSw TikTok - https://www.tiktok.com/@kanikachaddagupta?lang=en Pinterest - https://www.pinterest.com/kanikachaddagupta/ Podcast - https://kanikachaddagupta.com/podcast/ Connect with Jen!Jen's Website - https://jenhatmaker.com/ Jen's Instagram - https://instagram.com/jenhatmakerJen's Twitter - https://twitter.com/jenHatmaker/ Jen's Facebook - https://facebook.com/jenhatmakerJen's YouTube - https://www.youtube.com/user/JenHatmaker The For the Love Podcast is presented by Audacy. To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

Podcast: FGFR3 Alteration Status and Immunotherapy in Urothelial Cancer

JCO Precision Oncology Conversations

Play Episode Listen Later Dec 17, 2025 18:51

JCO PO author Dr. Shilpa Gupta at Cleveland Clinic Children's Hospital shares insights into her article, "Fibroblast Growth Factor Receptor 3 (FGFR3) Alteration Status and Outcomes on Immune Checkpoint Inhibitors (ICPI) in Patients with Metastatic Urothelial Carcinoma". Host Dr. Rafeh Naqash and Dr. Gupta discuss how FGFR3 combined with TMB emerged as a biomarker that may be predictive for response to ICPI in mUC. TRANSCRIPT Dr. Rafeh Naqash: Hello and welcome to JCO Precision Oncology Conversations, where we bring you engaging conversations with authors of clinically relevant and highly significant JCO PO articles. I'm your host, Dr. Rafeh Naqash, podcast editor for JCO Precision Oncology and Associate Professor at the OU Health Stephenson Cancer Center. Today I am excited to be joined by Dr. Shilpa Gupta, Director of Genitourinary Medical Oncology at the Cancer Institute and co-leader of the GU Oncology Program at the Cleveland Clinic, and also lead author of the JCO PO article titled "Fibroblast Growth Factor Receptor 3 Alteration Status and Outcomes on Immune Checkpoint Inhibitors in Patients With Metastatic Urothelial Carcinoma." At the time of this recording, our guest's disclosures will be linked in the transcript. Shilpa, welcome again to the podcast. Thank you for joining us today. Dr. Shilpa Gupta: Thank you, Rafeh. Honor to be here with you again. Dr. Rafeh Naqash: It is nice to connect with you again after two years, approximately. I think we were in our infancy of our JCO PO podcast when we had you first time, and it has been an interesting journey since then. Dr. Shilpa Gupta: Absolutely. Dr. Rafeh Naqash: Well, excited to talk to you about this article that you published. Wanted to first understand what is the genomic landscape of urothelial cancer in general, and why should we be interested in FGFR3 alterations specifically? Dr. Shilpa Gupta: Bladder cancer or urothelial cancer is a very heterogeneous cancer. And while we find there is a lot of mutations can be there, you know, like BRCA1, 2, in HER2, in FGFR, we never really understood what is driving the cancer. Like a lot of old studies with targeted therapies did not really work. For example, we think VEGF can be upregulated, but VEGF inhibitors have not really shown definite promise so far. Now, FGFR3 receptor is the only therapeutic target so far that has an FDA approved therapy for treating metastatic urothelial cancer patients, and erdafitinib was approved in 2019 for patients whose tumors overexpressed FGFR3 mutations, alterations, or fusions. And in the landscape of bladder cancer, it is important because in patients with non-muscle invasive bladder cancer, about 70 to 80% patients can have this FGFR3. But as patients become metastatic, the alterations are seen in, you know, only about 10% of patients. So the clinical trials that got the erdafitinib approved actually used archival tumor from local cancer. So when in the real world, we don't see a lot of patients if we are trying to do metastatic lesion biopsies. And why it is important to know this is because that is the only targeted therapy available for our patients right now. Dr. Rafeh Naqash: Thank you for giving us that overview. Now, on the clinical side, there is obviously some interesting data for FGFR3 on the mutation side and the fusion side. In your clinical practice, do you tend to approach these patients differently when you have a mutation versus when you have a fusion? Dr. Shilpa Gupta: We can use the treatment regardless of that. Dr. Rafeh Naqash: I recently remember I had a patient with lung cancer, squamous lung cancer, who also had a synchronous bladder mass. And the first thought from multiple colleagues was that this is metastatic lung. And interestingly, the liquid biopsy ended up showing an FGFR3-TACC fusion, which we generally don't see in squamous lung cancers. And then eventually, I was able to convince our GU colleagues, urologists, to get a biopsy. They did a transurethral resection of this tumor, ended up being primary urothelial and synchronous lung, which again, going back to the FGFR3 story, I saw in your paper there is a mention of FGFR3-TACC fusions. Anything interesting that you find with these fusions as far as biology or tumor behavior is concerned? Dr. Shilpa Gupta: We found in our paper of all the patients that were sequenced that 20% had the pathognomonic FGFR3 alteration, and the most common were the S249C, and the FGFR3-TACC3 fusion was in 45 patients. And basically I will say that we didn't want to generate too much as to fusion or the differences in that. The key aspect of this paper was that historically there were these anecdotal reports saying that patients who have FGFR alterations or mutations, they may not respond well to checkpoint inhibitors because they have the luminal subtype. And these were backed by some preclinical data and small anecdotal reports. But since then, we have seen that, and that's why a lot of people would say that if somebody's tumor has FGFR3, don't give them immunotherapy, give them erdafitinib first, right? So then we had this Phase 3 trial called the THOR trial, which actually showed that giving erdafitinib before pembrolizumab was not better. That debunked that myth, and we are actually reiterating that because in our work we found that patients who had FGFR3 alterations or fusions, and if they also have TMB-high, they actually respond very well to single agent immunotherapy. And that is, I think, very important because it tells us that we are not really seeing that so-called potential of resistance to immunotherapy in these patients. So to answer your question, yeah, we did see those differences, but I wouldn't say that any one marker is more prominent. Dr. Rafeh Naqash: The analogy is kind of similar to what we see in lung cancer with these mutations called STK11/KEAP1, which are also present in some other tumors. And one of the questions that I don't think has been answered is when you have in lung cancer, if you extrapolate this, where doublet or single agent immunotherapy doesn't do as well in tumors that are STK11 mutated. But then if you have a high TMB, question is does that TMB supersede or trump the actual mutation? Could that be one reason why you see the TMB-high but FGFR3 altered tumors in your dataset responding or having better outcomes to immunotherapy where potentially there is just more neoantigens and that results in a more durable or perhaps better response to checkpoint therapy? Dr. Shilpa Gupta: It could be. But you know, the patients who have FGFR alterations are not that many, right? So we have already seen that just patients with TMB-high respond very well to immunotherapy. Our last podcast was actually on that, regardless of PD-L1 that was a better predictor of response to immunotherapy. So I think it's not clear if this is adding more chances of response or not, because either way they would respond. But what we didn't see, which was good, that if they had FGFR3, it's not really downplaying the fact that they have TMB-high and that patients are not responding to immunotherapy. So we saw that regardless, and that was very reassuring. Dr. Rafeh Naqash: So if tomorrow in your clinic you had an individual with an FGFR3 alteration but TMB-high, I guess one could be comfortable just going ahead with immunotherapy, which is what the THOR trial as you mentioned. Dr. Shilpa Gupta: Yes, absolutely. And you know, when you look at the toxicity profiles of pembrolizumab and erdafitinib, really patients really struggle with using the FGFR3 inhibitors. And of course, if they have to use it, we have to, and we reserve it for patients. But it's not an easy drug to tolerate. Currently the landscape is such that, you know, frontline therapy has now evolved with an ADC and immunotherapy combinations. So really if patients progress and have FGFR3 alterations, we are using erdafitinib. But let's say if there were a situation where a patient has had chemotherapy, no immunotherapy, and they have FGFR3 upregulation and TMB-high, yes, I would be comfortable with using only pembrolizumab. And that really ties well together what we saw in the THOR trial as well. Dr. Rafeh Naqash: Going to the clinical applications, you mentioned a little bit of this in the manuscript, is combination therapies. You alluded to it a second back. Everything tends to get combined with checkpoint therapy these days, as you've seen with the frontline urothelial, pembrolizumab with an ADC. What is the landscape like as far as some of these FGFR alterations are concerned? Is it reasonable to combine some of those drugs with immune checkpoint therapy? And what are some of the toxicity patterns that you've potentially seen in your experience? Dr. Shilpa Gupta: So there was indeed a trial called the NORSE trial. It was a randomized trial but not a comparative cohort, where they looked at FGFR altered patients. And when they combined erdafitinib plus cetrelimab, that did numerically the response rates were much higher than those who got just erdafitinib. So yeah, the combination is definitely doable. There is no overlapping toxicities. But unfortunately that combination has not really moved forward to a Phase 3 trial because it's so challenging to enroll patients with such kind of rare mutations on large trials, especially to do registration trials. And since then the frontline therapy has evolved to enfortumab vedotin and pembrolizumab. I know there is an early phase trial looking at a next generation FGFR inhibitor. There is a triplet combination looking in Phase 1 setting with a next generation FGFR inhibitor with EV-pembro. However, it's not a randomized trial. So you know, I worry about such kinds of combinations where we don't have a path for registration. And in the four patients that have been treated, four or five patients in the early phase as a part of basket trial, the toxicities were a lot, you know, when you combine the EV-pembro and an FGFR3 inhibitor, we see more and more toxicity. So the big question is do we really need the "kitchen sink" approach when we have a very good doublet, or unless the bar is so high with the doublet, like what are we trying to add at the expense of patient toxicity and quality of life is the big question in my mind. Dr. Rafeh Naqash: Going back to your manuscript specifically, there could be a composite biomarker. You point out like FGFR in addition to FGFR TMB ends up being predictive prognostic there. So that could potentially be used as an approach to stratify patients as far as treatment, whether it's a single agent versus combination. Maybe the TMB-low/FGFR3 mutated require a combination, but the TMB-high/FGFR mutated don't require a combination, right? Dr. Shilpa Gupta: No, that's a great point, yeah. Dr. Rafeh Naqash: But again, very interesting, intriguing concepts that you've alluded to and described in this manuscript. Now, a quick take on how things have changed in the bladder cancer space in the last two years. We did a podcast with you regarding some biomarkers as you mentioned two years back. So I really would like to spend the next minute to two to understand how have things changed in the bladder cancer space? What are some of the exciting things that were not there two years back that are in practice now? And how do you anticipate the next two years to be like? Maybe we'll have another podcast with you in another two years when the space will have changed even more. Dr. Shilpa Gupta: Certainly a lot has happened in the two years, you know. EV-pembro became the universal frontline standard, right? We have really moved away from cisplatin eligibility in metastatic setting because anybody would benefit from EV-pembro regardless of whether they are candidates for cisplatin or not, which historically was relevant. And just two days ago, we saw that EV-pembro has now been approved for localized bladder cancer for patients who are cisplatin ineligible or refusing. So, you know, this very effective regimen moving into earlier setting, we now have to really think of good treatment options in the metastatic setting, right? So I think that's where a lot of these novel combinations may come up. And what else we've seen is in a tumor agnostic trial called the DESTINY-PanTumor trial, patients who had HER2 3+ on immunohistochemistry, we saw the drug approval for T-DXd, and I think that has kind of reinvigorated the interest in HER2 in bladder cancer, because in the past targeting HER2 really didn't work. And we still don't know if HER2 is a driver or not. And at ESMO this year, we saw an excellent study coming out of China with DV which is targeting HER2, and toripalimab, which is a Chinese checkpoint inhibitor, showing pretty much similar results to what we saw with EV-pembro. Now, you know, not to do cross-trial comparisons, but that was really an amazing, amazing study. It was in the presidential session. And I think the big question is: does that really tell us that HER2-low patients will not benefit? Because that included 1+, 2+, 3+. So that part we really don't know, and I think we want to study from the EV-302 how the HER2 positive patients did with EV and pembro. So that's an additional option, at least in China, and hopefully if it gets approved here, there is a trial going on with DV and pembro. And lastly, we've seen a very promising biomarker, like ctDNA, for the first time in bladder cancer in the adjuvant setting guiding treatment with adjuvant atezolizumab. So patients who were ctDNA positive derived overall survival and recurrence-free survival benefit. So that could help us select moving forward with more studies. We can spare unnecessary checkpoint inhibitors in patients who are not going to benefit. So I think there is a lot happening in our field, and this will help do more studies because we already have the next generation FGFR inhibitors which don't have the toxicities that erdafitinib comes with. And combining those with these novel ADCs and checkpoint inhibitors, you know, using maybe TMB as a biomarker, because we really need to move away from PD-L1 in bladder cancer. It's shown no utility whatsoever, but TMB has. Dr. Rafeh Naqash: Well, thank you so much, Shilpa, for that tour de force of how things have changed in bladder cancer. There used to be a time when lung and melanoma used to lead this space in terms of the number of approvals, the biomarker development. It looks like bladder cancer is shifting the trend at this stage. So definitely exciting to see all the new changes that are coming up. I'd like to spend another minute and a half on your career. You've obviously been a leader and example for many people in the GU space and beyond. Could you, for the sake of our early career especially, the trainees and other listeners, describe how you focused on things that you're currently leading as a leader, and how you shaped your career trajectory over the last 10 years? Dr. Shilpa Gupta: That's a really important question, Rafeh, and you and I have had these discussions before, you know, being an IMG on visas like you, and being in different places. I think I try to make the most of it, you know, instead of focusing on the setbacks or the negative things. Like tried to grab the opportunities that came along. When I was at Moffitt, got to get involved with the Phase 1 trial of pembrolizumab in different tumor types. And just keeping my options open, you know, getting into the bladder cancer at that time when I wanted to really do only prostate, but it was a good idea for me to keep my options open and got all these opportunities that I made use of. I think an important thing is to, like you said, you know, have a focus. So I am trying to focus more on biomarkers that, you know, we know that 70% patients will respond to EV-pembro, right? But what about the remaining 30%? Like, so I'm really trying to understand what determines hyperprogressors with such effective regimens who we really struggle with in the clinic. They really don't do well with anything we give them after that. So we are doing some work with that and also trying to focus on PROs and kind of patient-reported outcomes. And a special interest that I've now developed and working on it is young-onset bladder cancer. You know, the colorectal cancer world has made a lot of progress and we are really far behind. And bladder cancer has historically been a disease of the elderly, which is not the case anymore. We are seeing patients in their 30s and 40s. So we launched this young-onset bladder cancer initiative at a Bladder Cancer Advocacy Network meeting and now looking at more deep dive and creating a working group around that. But yeah, you know, I would say that my philosophy has been to just take the best out of the situation I'm in, no matter where I am. And it has just helped shape my career where I am, despite everything. Dr. Rafeh Naqash: Well, thank you again. It is always a pleasure to learn from your experiences and things that you have helped lead. Appreciate all your insights, and thank you for publishing with JCO PO. Hopefully we will see more of your biomarker work being published and perhaps bring you for another podcast in a couple of years. Dr. Shilpa Gupta: Yeah, thank you, Rafeh, for the opportunity. And thanks to JCO PO for making these podcasts for our readers. So thanks a lot. Dr. Rafeh Naqash: Thank you for listening to JCO Precision Oncology Conversations. Don't forget to give us a rating or review and be sure to subscribe so you never miss an episode. You can find all ASCO shows at asco.org/podcast. The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. DISCLOSURES Dr. Shilpa Gupta Stock and Other Ownership Interests: Company: BioNTech SE, Nektar Consulting or Advisory Role: Company: Gilead Sciences, Pfizer, Merck, Foundation Medicine, Bristol-Myers Squibb/Medarex, Natera, Astellas Pharma, AstraZeneca, Novartis, Johnson & Johnson/Janssen Research Funding: Recipient: Your Institution Company: Bristol Myers Squibb Foundation, Merck, Roche/Genentech, EMD Serono, Exelixis, Novartis, Tyra Biosciences, Pfizer, Convergent Therapeutics, Acrivon Therapeutics, Flare Therapeutics, Amgen Travel, Accommodations, Expenses: Company: Pfizer, Astellas Pharma, Merck

director china chinese cancer hospitals patients phase status wanted associate professor pros fda thor pfizer ev outcomes gu astrazeneca gupta norse merck dv cleveland clinic novartis accommodations immunotherapy asco adc moffitt brca1 shilpa her2 alteration vegf adcs pd l1 tmb esmo natera cancer institute muc ctdna immune checkpoint inhibitors emd serono foundation medicine fgfr cleveland clinic children t dxd roche genentech transcript dr disclosures dr genitourinary medical oncology

92 How a CEO Biotech Founder Scaled to IPO Without Silicon Valley

CPO PLAYBOOK

Play Episode Listen Later Dec 16, 2025 44:51

What does it take to build a biotech company without burning billions—or losing your conviction? In this episode of CPO PLAYBOOK, Felicia Shakiba sits down with Dr. Shalabh Gupta, Founder & CEO of Unicycive Therapeutics, a physician-turned-Wall-Street-analyst who built and took a biotech company public in a way few ever do. Dr. Gupta shares how he raised $150M+ in public markets, went public with just one employee, and scaled to FDA submission readiness with only 22 people—all without relying on traditional Silicon Valley venture capital. This conversation unpacks what real CEO discipline looks like in one of the most unforgiving industries in the world—and what leaders in any industry can learn from it. You'll learn: • Why great CEOs start with the problem—not the product • How to scale a capital-intensive business with radical focus • Why FDA alignment is a leadership skill, not a regulatory hurdle • How public-market thinking changes founder decision-making • What investors actually look for in CEO credibility and trust Chapters 00:00 Introduction to Unisysive Therapeutics 04:27 Innovative Approach to Biotech 07:55 Understanding the Biotech Landscape 10:39 Transition from Medicine to Wall Street 14:08 Lessons from Genentech 19:46 Building a Company Alone 22:47 The Importance of Networking 27:00 Engaging with the FDA 30:57 Raising Capital in Biotech 41:58 Navigating Investor Relationships This episode is a masterclass in purpose-driven leadership, capital discipline, and building companies that last. — Subscribe to CPO PLAYBOOK for more conversations at the intersection of leadership, innovation, and capital strategy: https://www.cpoplaybook.com/newsletter Need support scaling leadership or culture? Let's talk: https://www.cpoplaybook.com/contact-us

ceo founders lessons building medicine transition silicon valley wall street ceos engaging fda playbook gupta biotech scaled 150m raising capital

Stop Waiting for Lightning To Strike with Lexy Franklin and Surbhi Gupta

Women In Product

Play Episode Listen Later Dec 16, 2025 56:02

Visibility is a superpower for leaders—but building it authentically can feel challenging. On this episode, Surbhi Gupta, host of The Visibility Equation and seasoned product leader, sits down with Lexy Franklin, CEO & Founder of Sidebar, to explore how leaders can own their narrative, amplify their impact, and connect with their authentic selves.Lexy shares practical strategies on building visibility, overcoming public speaking anxiety, nurturing relationships, and navigating the leadership journey. Together, they dive into inspiring stories, actionable insights, and the realities behind professional growth at leadership levels

From IPO to International Bridge: Vinita Gupta in Conversation with Nalini Elkins

Commonwealth Club of California Podcast

Play Episode Listen Later Dec 15, 2025 59:24

From patents to IPOs to international bridge titles, Vinita Gupta has navigated male-dominated arenas with clarity and courage. In this fireside chat with Nalini Elkins, she shares fresh takes from her new memoir on resilience, inclusion, and building durable success in a volatile world—plus what it takes to keep learning through every pivot. join us to hear her timely playbook for founders, operators and the curious. Vinita Gupta is a Silicon Valley entrepreneur and the first woman of Indian origin to take a company public in the United States. Her memoir, The Woman in Deed: Road to IPO, Bridge Tables, and Beyond, traces a life of invention, leadership, and competitive bridge at the highest levels. She writes on innovation, integrity, and reinvention across the India–U.S. corridor. Nalini Elkins, the CEO and founder of Inside Products, Inc., is a recognized leader in the field of computer performance measurement and analysis. She is also the chief technical officer and co-founder of Outside the Stacks. An accomplished software product designer, developer and strategist, she has founded or co-founded three high-tech start-ups over the course of her career. In 2014, Nalini was awarded the prestigious AA Michelson Award by the Computer Measurement Group (CMG). An International Relations Member-led Forum program. Forums at the Club are organized and run by volunteer programmers who are members of The Commonwealth Club, and they cover a diverse range of topics. Learn more about our Forums. Commonwealth Club World Affairs is a public forum. Any views expressed in our programs are those of the speakers and not of Commonwealth Club World Affairs. Organizer: Frank Price Learn more about your ad choices. Visit megaphone.fm/adchoices

united states ceo conversations woman club international indian silicon valley bridge forum ipo gupta stacks forums elkins nalini commonwealth club

074: Taruna Gupta: 3D-Printed Architecture with Defining Humanity

Architectette

Play Episode Listen Later Dec 15, 2025 34:55

Taruna Gupta is a Senior Associate at HGA Milwaukee where she works on projects that champion holistic design, equity, and sustainability. She is President of Wisco NOMA and is a board member of Women in Design Milwaukee. Taruna is also Co-Founder and President of Defining Humanity where she leads global initiatives such as 3D-printed schools and housing solutions that redefine architecture's role in addressing equity and access in communities around the world.We talk about: - Lessons Taruna has learned from practicing architecture in India, Italy, France, and the United States. We talk about the ways in which these roles have expanded her cultural fluency and strengthened her adaptability in terms of the design process, construction techniques, labor models, and metric vs imperial systems.- The origin of Defining Humanity and how she has helped to build a volunteer network of professionals that collaborate to significantly impact underserved communities worldwide through architectural interventions.- 3D printing schools in Madagascar and the importance of listening to and engaging communities, ensuring people feel truly heard.- Taruna's advice for authentic networking, leaning into your passions during conversation, and using the “buddy system” to make professional events less intimidating.>>>Connect with Taruna:LinkedIn: https://www.linkedin.com/in/tarunagupta/Defining Humanity Website: https://www.defininghumanity.org/Defining Humanity Instagram: @defininghumanity>>>Connect with Architectette:- Website: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ www.architectette.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ (Learn more)- Instagram:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ @architectette⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ (See more)- Newsletter:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ www.architectette.com/newsletter⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ (Behind the Scenes Content)- LinkedIn:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ The Architectette Podcast⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Page and/or⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Caitlin Brady⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠>>> Support Architectette:- Leave us a rating and review!>>>Music by⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ AlexGrohl⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ from ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Pixabay⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠.

united states music women president france co founders italy 3d humanity defining newsletter architecture madagascar gupta pixabay senior associate 3d printed alexgrohl

Myth-busting in diabetes is vital

diabetes conditions vital bp gupta mythbusting vitamin b12 diabetes care diabetic retinopathy sunil gupta

Play Episode Listen Later Dec 15, 2025 28:50

Dr. Sunil Gupta addressed several common diabetes-related myths—especially those that spread during festivals—such as the false belief that diabetes spreads through touch, that bitter gourd juice is a cure, or that eating sweets directly causes diabetes. He clarified that such misconceptions can misguide people and delay proper care. Dr. Gupta explained that tingling or numbness in the hands and feet is not always due to high sugar levels; it can also be caused by nerve pressure, sitting posture, or Vitamin B12 deficiency. In Type 2 diabetes, medicines may reduce with disciplined lifestyle changes, but complete cure is rare. Diabetes may get “reversed” in specific situations such as gestational diabetes after delivery, stress-induced diabetes, or after bariatric surgery. He also highlighted that children's late-night gaming habits harm mental health and sometimes require psychological guidance. Dr. Gupta discussed the stages of Diabetic Retinopathy, noting that retinal damage cannot be reversed, though progression can be slowed with timely treatment. Conditions like Vitamin D3/B12 deficiency, infections, high BP, or glaucoma can also affect vision—so both diabetes and eye specialists should be consulted. Dr. Gupta emphasized that diabetes is a lifestyle condition and individuals should not be labeled as “patients.” Expert- Dr Sunil Gupta Anchor- Mrs. Shraddha Bharadwaj Podcast: 11/10/2019 Recorded at: Akashwani Nagpur

Trump Economic Panic

Play Episode Listen Later Dec 12, 2025 76:48

Jason Kander and Ravi Gupta break down Trump's chaotic attempt to rebrand the economy as he mocks “affordability,” confuses inflation with deflation, and delivers a meandering Pennsylvania rally full of distortions. They examine how Americans view Trump's economic record compared to the end of the Biden presidency and why his messaging isn't matching voters' lived experiences. Kander and Gupta also dig into Trump's $12 billion farm bailout sparked by his own tariffs, and the criticism that foreign competitors—not American farmers—benefited most. They explore Trump's push for a sweeping national AI rule to override state protections, as well as his surprising reversal on advanced chip exports to China. Plus, they look at Miami's first Democratic mayor in decades, the GOP's internal fight over Obamacare subsidies, and escalating MAGA infighting heading into 2026. This and more on the podcast that helps you, the majority of Americans who believe in progress, convince your conservative friends and family to join us—this is Majority 54! Hims: Thanks to HIMS! Start your free online visit today at https://hims.com/majority for your personalized ED treatment options Aura Frames: Exclusive $35 off Carver Mat at https://on.auraframes.com/MAJORITY54 Promo Code MAJORITY54 Shopify: Shopify: Sign up for your one-dollar-per-month trial and start selling today at https://SHOPIFY.com/majority Subscribe to Ravi's Substack: https://realravigupta.substack.com/ For more information visit: https://www.ravimgupta.com/analog Shout out to https://immigrantslist.org where people can donate to help get real immigration facts out! Majority 54 on Twitter: https://twitter.com/majority54 Jason on Twitter: https://twitter.com/JasonKander Jason on Instagram: https://www.instagram.com/jasonkander/ Ravi on Twitter: https://twitter.com/RaviMGupta Ravi on Instagram: https://www.instagram.com/ravimgupta Ravi on Youtube: https://www.youtube.com/@LostDebate Remember to subscribe to ALL the MeidasTouch Network Podcasts: MeidasTouch: https://www.meidastouch.com/tag/meidastouch-podcast Legal AF: https://www.meidastouch.com/tag/legal-af MissTrial: https://meidasnews.com/tag/miss-trial The PoliticsGirl Podcast: https://www.meidastouch.com/tag/the-politicsgirl-podcast The Influence Continuum: https://www.meidastouch.com/tag/the-influence-continuum-with-dr-steven-hassan Mea Culpa with Michael Cohen: https://www.meidastouch.com/tag/mea-culpa-with-michael-cohen The Weekend Show: https://www.meidastouch.com/tag/the-weekend-show Burn the Boats: https://www.meidastouch.com/tag/burn-the-boats Majority 54: https://www.meidastouch.com/tag/majority-54 Political Beatdown: https://www.meidastouch.com/tag/political-beatdown On Democracy with FP Wellman: https://www.meidastouch.com/tag/on-democracy-with-fpwellman Uncovered: https://www.meidastouch.com/tag/maga-uncovered Learn more about your ad choices. Visit megaphone.fm/adchoices

Practical Guidance for a Healthier and Happier Life with Diabetes

diabetes healthier highlighting healthy living gupta stressing happier life cgm diabetes care high fat practical guidance managing diabetes sunil gupta hfss

Play Episode Listen Later Dec 12, 2025 28:21

Throughout the session, Dr. Sunil Gupta shared practical and easy-to-follow advice on managing diabetes effectively in daily life. He emphasized the importance of moderation during festivals, advising people to enjoy the “sweetness of words” rather than consuming excessive sweets. A positive attitude, self-discipline, and mindful choices, he said, are crucial for maintaining good health. Dr. Gupta encouraged individuals with diabetes to monitor their blood sugar regularly using a glucometer or continuous glucose monitoring (CGM) system to understand their glucose trends and make timely adjustments in diet, medication, and physical activity. Highlighting that 50–70% of people with diabetes are overweight, he explained the “Fit Fat Concept,” which means that even if a person carries extra weight, staying active and physically fit can significantly reduce diabetes-related risks. He also recommended avoiding HFSS foods (High Fat, High Salt, and High Sugar) and instead including more fiber-rich foods, vegetables, and fruits in the daily diet. Stressing the importance of consistent exercise, proper hydration, and stress control, Dr. Gupta concluded that diabetes management goes beyond medicines — it requires awareness, lifestyle balance, and a positive mindset for long-term well-being. Expert- Dr Sunil Gupta Anchor- Mrs. Shraddha Bharadwaj Podcast: 25/10/2019 Recorded at: Akashwani Nagpur Episode: 96

PCT Reassessed

Critical Matters

Play Episode Listen Later Dec 11, 2025 43:15

In this episode, Dr. Zanotti discusses the role of Procalcitonin in the ICU. He is joined by Dr. Simran Gupta, an infectious disease specialist at Brigham & Women's Hospital in Boston. Dr. Gupta has additional training in Clinical Research, Transplant, and Infectious Disease. She recently published an article on reassessing the role of Procalcitonin in critically ill patients with sepsis. Additional resources: Reassessing Procalcitonin-Guided Antibiotic Therapy in Critically Ill Patients with Sepsis: Lessons from the ADAPT-Sepsis Trial. S. Gupta, et al. Clinical Infectious Disease 2025: https://pubmed.ncbi.nlm.nih.gov/40579227/ Biomarker-Guided Antibiotic Duration for Hospitalized Patients With Suspected Sepsis: The ADAPT-Sepsis Randomized Clinical Trial. JAMA 2025: https://pubmed.ncbi.nlm.nih.gov/39652885/ Procalcitonin-guided antibiotic therapy may shorten the length of treatment and may improve survival- a systematic review and meta-analysis. M Papp, et al. Crit Care 2023: https://pubmed.ncbi.nlm.nih.gov/37833778/ Books and entertainment mentioned in this episode: Shantaram: A Novel. By Gregory David Roberts: https://bit.ly/4ovVHKX SHANTARAM – Apple TV series: https://tv.apple.com/us/show/shantaram/umc.cmc.atxsrive40xli3zh3uxjimut

women books hospitals icu transplants gupta infectious diseases jama brigham clinical research zanotti critically ill patients procalcitonin

Safe Fasting and Smart Diabetes Management

travel safe smart fasting gupta hba1c diabetes management sunil gupta

Play Episode Listen Later Dec 11, 2025 27:49

Dr. Sunil Gupta advises that if blood sugar is well-controlled and only mild medications are used, fasting can be observed safely. However, during fasting, one should consume light diets such as milk, fruits, or bhagar at intervals to prevent hypoglycemia. A frequent craving for sweets may indicate prediabetes, as excessive intake can overwork pancreatic beta cells and eventually lead to diabetes. Dr. Gupta explains that insulin in the body functions in two forms — basal insulin, which works continuously 24×7, and bolus insulin, which is secreted by beta cells in response to meals. For Type 1 diabetes, research on pancreatic or beta cell transplants, stem cell therapy etc. are ongoing, though a permanent cure remains under study. The HbA1c target should ideally remain between 6.5–7, though elderly patients may maintain slightly higher levels for safety. (may be 7.5% or 8%) While traveling, always carry insulin, medications, glucose tablets, and a diabetes identity card in your hand luggage. During festivals, treat prasad as a symbol of devotion rather than a food portion. Avoid excess sweets, stay active, and extra parikrama may be practiced as a healthy form of exercise. Expert- Dr Sunil Gupta Anchor- Mrs. Shraddha Bharadwaj Podcast: 23/08/2019 Recorded at: Akashwani Nagpur Episode: 95

Success Leaves Clues: Ep276 - The Human Side of Employment Law with guest Neena Gupta, Partner at Gowling WLG

Success Leaves Clues with Robin Bailey and Al McDonald

Play Episode Listen Later Dec 11, 2025 33:53

In this episode of Success Leaves Clues, hosts Robin Bailey and Al McDonald welcome Neena Gupta, Partner at Gowling WLG and one of Canada's most respected voices in employment, labour, and human rights law. Neena brings a refreshingly human lens to the legal world, blending precision with empathy, mentorship, and real-world practicality. Neena shares her journey as a South Asian woman in law, her passion for mentoring the next generation, and how trust in leadership is built at the intersection of competence and kindness. Together, they explore today's workplace challenges including generational shifts, inflation pressures, hybrid work, recruitment struggles, and the evolving definition of work life balance. The conversation also dives into what foreign companies must understand when expanding into Canada, the importance of strong employment agreements, and why proactive legal relationships save time, money, and stress. Neena closes with a powerful reflection on community, service, and planting trees for future generations through her leadership with United Way. This episode is a grounded, insightful masterclass on leadership, people-first systems, and building businesses with integrity in complex economic times. You'll hear about: Neena's path into law and mentoring young professionals Why trust is built through competence and kindness Generational shifts in work life balance and employee expectations The real challenges employers face with recruitment and retention How inflation is impacting employees and businesses across Canada Why hybrid work is here to stay Key pitfalls for foreign companies expanding into Canada The importance of employment agreements as risk management tools How to build a proactive relationship with your lawyer Planting trees for the future through community leadership and service We talk about: 00:00 Introduction 03:00 Neena's journey into law and mentoring young professionals 05:30 Balancing legal precision with personal approachability 07:30 Trust at the intersection of competence and kindness 09:30 Recruitment, retention, and generational workplace shifts 12:00 Inflation pressures on employees and employers 14:30 Hybrid work, flexibility, and modern leadership 17:00 Expanding into Canada, legal pitfalls and must know foundations 20:00 Employment agreements and foreign employer risk management 22:30 Benefits, compliance, and cross border considerations 25:00 How to work effectively with your lawyer 28:00 Building proactive legal relationships 30:00 Planting trees through mentoring and community leadership 32:30 Neena's work with United Way and giving back 35:00 Final reflections on leadership, service, and purpose Connect with Neena LinkedIn: https://www.linkedin.com/in/neena-gupta-0107aa4 Website: https://gowlingwlg.com/en-ca Connect with Us LinkedIn: Robin Bailey and Al McDonald Website: Aria Benefits and Life & Legacy Advisory Group

How to Choose, Use, and Trust AI Models with Manav Gupta, Vice President and CTO, IBM Canada {Replay}

IBM Analytics Insights Podcasts

Play Episode Listen Later Dec 10, 2025 49:15

Send us a textOn this replay of Making Data Simple, Manav Gupta, VP and CTO of IBM Canada, jumps straight into the world of large language models and what they really mean for businesses trying to scale AI. From how today's models are built and tuned, to where the next generation is headed, Manav translates complex AI concepts into practical guidance for leaders, practitioners, and anyone trying to cut through the hype.The discussion spans everything from model architectures and IBM's Granite family, to how to pick the right model for your use case, balance innovation with governance, and build the skills needed to stay relevant in an AI-first world. If you want a clear, no-nonsense guide to “all things AI models” from someone advising enterprise clients every day, this replay is for you.02:04 Jumping Right into AI! 02:59 Meet Manav Gupta 08:17 Let's Talk All Things Models 27:20 How to Choose the Right Models 31:48 Where are the Models Going??? 46:01 How to Learn AILinkedIn: https://www.linkedin.com/in/mgupta76/ IBM Granite Models: https://www.ibm.com/graniteWant to be featured as a guest on Making Data Simple? Reach out to almartintalksdata@gmail.com and share why you should be next.Hashtags#makingdatasimplepodcast #MakingDataSimple #AI #LargeLanguageModels #AIModels #ArtificialIntelligence #IBMCanada #ManavGupta #AIInnovation #TechLeadership #TechPodcast #IBMGranite #LearnAIRelatedWant to be featured as a guest on Making Data Simple? Reach out to us at almartintalksdata@gmail.com and tell us why you should be next. The Making Data Simple Podcast is hosted by Al Martin, WW VP Technical Sales, IBM, where we explore trending technologies, business innovation, and leadership ... while keeping it simple & fun.

trust ai vice president reach ibm cto hashtags gupta granite ai models manav al martin ibm canada

How to Choose, Use, and Trust AI Models with Manav Gupta, Vice President and CTO, IBM Canada {Replay}

Making Data Simple

Play Episode Listen Later Dec 10, 2025 49:15

trust ai vice president reach ibm cto hashtags gupta granite ai models manav al martin ibm canada

#704 - Dr. Arun Kumar Gupta

ON AIR

Play Episode Listen Later Dec 10, 2025 70:09

Dr. Arun Kumar Gupta is a leading Nepali rheumatologist, serving as President of the Nepal Rheumatology Association. He heads the Rheumatology Department at Norvic International Hospital and founded the Rheumatology Arthritis Center (RAC). He is recognized for his expertise in autoimmune disorders and his contributions to public medical education.

president kumar gupta nepali

Insulin is Safe and Best for Diabetes Control

safe exercise diet foot diabetes limit gupta insulin doses diabetes care hyperinsulinemia sunil gupta diabetes control

Play Episode Listen Later Dec 10, 2025 27:21

Dr. Sunil Gupta shared key insights for diabetes patients. Diabetes affects not just the pancreas but blood vessels throughout the body, with the liver being particularly vulnerable. Hyperinsulinemia (excess insulin) and long-term high blood sugar, high cholesterol, and high triglycerides can lead to fatty liver, which may progress to fibrosis or cirrhosis of liver. Dr. Gupta emphasized that human insulin is safe and effective, while insulin analogs (ultra-fast and ultra-long) are more physiologically aligned with the body's needs. Doses should be adjusted based on weight. Every person with diabetes should have a glucometer, as frequent monitoring helps control sugar levels and adjust doses. Diet and lifestyle play a crucial role. Limit sugar, jaggery, sweets, and honey, and prefer brown rice for its lower glycemic index. Exercise, weight management, and controlling blood pressure and cholesterol are essential. Foot care, eye check-ups, and avoiding alcohol, smoking, and tobacco are vital. For children with Type 1 diabetes, parent training, workshops, and insulin learning programs ensure safe management and prevent complications. Expert- Dr Sunil Gupta Anchor- Mrs. Shraddha Bharadwaj Podcast: 14/06/2019 Recorded at: Akashwani Nagpur Episode: 94

Ep. 141 - Fibroid Treatment Alternatives with Dr. Bhatia: Save Your Uterus Without Surgery

Fusionary Health

Play Episode Listen Later Dec 9, 2025 45:21

Dr. Shivani Gupta welcomes board-certified interventional radiologist Dr. Shivank Bhatia, founder of Florida Prostate Centers and Florida Fibroid Centers, to discuss groundbreaking minimally invasive alternatives to common surgeries. Dr. Bhatia, internationally recognized for pioneering embolization therapies, shares his expertise on preserving organs while effectively treating benign conditions. Dr. Gupta opens up about her personal journey battling a 10-centimeter fibroid and almost undergoing unnecessary hysterectomy before discovering embolization. Together, they reveal shocking statistics: 25 million American women have fibroids with 600,000 hysterectomies performed annually (half for fibroids), while over 20 million men face prostate issues with many unaware of minimally invasive options. Learn how these outpatient procedures offer 90% success rates with only 4-5 days recovery versus weeks for surgery, helping patients avoid premature menopause, sexual dysfunction, and other serious complications.Key Highlights:• The dramatic difference between fibroid embolization (4-5 days recovery) vs. hysterectomy (4-6 weeks recovery)• Why 300,000+ women annually may be having unnecessary hysterectomies• The hidden dangers of early menopause and long-term health consequences• How prostate enlargement affects 60% of men over 60 and 80% of men over 80• The three major risks of prostate surgery that embolization avoids• Why over 230 physicians have chosen Dr. Bhatia for their own treatment• Prostate embolization's impressive 5-year efficacy rates comparable to surgical options• Dr. Bhatia's mission to "save your organs" from unnecessary removalWhy You Should WatchThis episode contains potentially life-saving information for anyone facing fibroid or prostate issues. Dr. Bhatia shares alternatives to major surgery that preserve vital organs and maintain quality of life with dramatically shorter recovery times and fewer side effects. Whether for yourself or someone you love, this knowledge empowers you to make truly informed healthcare decisions about benign conditions that affect millions of Americans.

american americans treatments surgery gupta prostate uterus bhatia comshow shivani gupta fibroid fusionary formulas treatment alternatives

The Human Code: Embedding Compassion into Technology, Leadership, and Care with Dr. Apurv Gupta, Founder and Board Member of A Loving Organization

Outcomes Rocket

Play Episode Listen Later Dec 8, 2025 20:56

This podcast is brought to you by Outcomes Rocket, your exclusive healthcare marketing agency. Learn how to accelerate your growth by going to⁠ outcomesrocket.com How do you build AI that actually feels loving to the people it serves? In this episode, Dr. Apurv Gupta, Founder and Board Member of A Loving Organization, explains that the Loving Organization Consortium aims to bring more love and compassion into healthcare by improving nine interconnected systems, people, processes, culture, workflows, and especially technology, through a framework called INTEGRATE. He and Ed Gaudet discuss how “loving AI” can ease clinician burden through tools like ambient listening, workflow automation, and emerging burnout-prediction technology, while emphasizing that tech alone is only 10–20% of the solution. Dr. Gupta stresses that effective technology requires human oversight, governance, feedback loops, and involvement from clinicians and patients in the design process. He highlights that organizations often miss these elements due to lack of awareness and capabilities, which the INTEGRATE framework seeks to build. Ultimately, he argues that love must be the foundational intention shaping systems, leadership, and AI, because technology is neutral but becomes “loving” only when embedded in a loving human environment. Tune in to explore how compassion-driven systems and “loving AI” can transform clinician well-being, patient care, and the future of healthcare! Resources Connect with and follow Dr. Apurv Gupta on LinkedIn. Follow A Loving Organization on LinkedIn and visit their website! Last Apurv Gupta RNS episode here!

founders ai care loving compassion code board members gupta integrate embedding resources connect technology leadership apurv

#138 - Prevalence of KIT D816V in anaphylaxis or systemic mast cell activation

The Itch: Allergies, Asthma & Immunology

Play Episode Listen Later Dec 5, 2025 43:59

Clonal mast cell disease is often missed because symptoms vary from person to person, tryptase levels can be normal, and bone marrow biopsies are hard to get. For some people, unexplained or very severe anaphylaxis may be an early sign of a clonal mast cell disease. In this episode, we review “Prevalence of KIT D816V in anaphylaxis or systemic mast cell activation,” published in October 2025 in the Journal of Allergy and Clinical Immunology. This paper, known as the PROSPECTOR trial, is looking at how often the KIT D816V mutation can be found using a blood test in adults who have had anaphylaxis or systemic mast cell activation symptoms. We break down why KIT D816V matters, how it connects to systemic mastocytosis, why HaT needs to be considered, and how newer blood tests may help doctors catch clonal mast cell disease earlier. What we cover in our episode about KIT D816V and anaphylaxis: Setting the stage: Understanding mast cell activation and anaphylaxis. Why KIT D816V matters: How this mutation fits into clonal mast cell disease, what blood testing can reveal, and when doctors still turn to a bone marrow biopsy. Making sense of tryptase and hereditary alpha-tryptasemia (HaT): Why baseline tryptase, the “20% + 2” rule, and HaT can make screening more complicated than it seems. What the PROSPECTOR trial uncovered: How often KIT D816V appeared in people with anaphylaxis, and other results on tryptase and HaT. How this helps patients: What these findings mean for anyone with unexplained or severe anaphylaxis, and how doctors combine KIT testing, tryptase, HaT, and symptoms to decide on next steps. Other podcast episodes about mast cell disease: Ep. 127: Management of indolent mastocytosis - A clinical yardstick Ep. 126: Management of mast cell activation syndrome - A clinical yardstick Ep. 121: Avapritinib vs Placebo in Indolent Systemic Mastocytosis - PIONEER Trial Ep. 118: The ISM Disconnect - Do Patients and Providers Agree on Symptom Control? Ep. 70 How do stress and low histamine diets impact mast cell disease? Ep. 63: Mast Cell Diseases & Systemic Mastocytosis: The Basic Science Ep. 65: The Symptoms and Triggers of Mast Cell Disease *********** The Itch Review, hosted by Dr. Gupta, Kortney, and Dr. Blaiss, explores allergy and immunology studies, breaking down complex research in conversations accessible to clinicians, patients, and caregivers. Each episode provides key insights from journal articles and includes a one-page infographic in the show notes for easy reference. *********** Made in partnership with The Allergy & Asthma Network. Thanks to Blueprint Medicines for sponsoring today's episode. This podcast is for informational purposes only and does not substitute professional medical advice. Always consult with your healthcare provider for any medical concerns.

management journal symptoms triggers gupta activation systemic placebos allergy prevalence anaphylaxis prospector kortney clinical immunology mast cell clonal blueprint medicines

War Crimes

Play Episode Listen Later Dec 4, 2025 69:17

Jason Kander and Ravi Gupta break down Trump's latest spiral after posting 160 times on Truth Social and then appearing to fall asleep in a cabinet meeting. They examine the escalating “Double Tap” scandal, from Pete Hegseth's shifting explanations to sharp criticism from Megyn Kelly, Brit Hume, Marco Rubio, and Rand Paul as Republicans contradict themselves in real time. The hosts also dig into Trump's shocking pardon of former Honduran President Juan Orlando Hernández and his commutation of private-equity CEO David Gentile, highlighting the uproar over freeing major drug traffickers and white-collar criminals. Kander and Gupta then turn to the National Guard shooting involving an Afghan asylee, breaking down the rigorous vetting process, the mental-health failures that followed, and why this was a support-system breakdown rather than an immigration failure. All that plus a quick look at the Tennessee special results on the podcast that helps you, the majority of Americans who believe in progress, convince your conservative friends and family to join us—this is Majority 54! Nutrafol: Get results you can run your fingers through! For a limited time, Nutrafol is offering our listeners ten dollars off your first month's subscription and free shipping when you go to https://Nutrafol.com and enter the promo code MAJORITY. Dupe: For a limited time, the first 10,000 people who go to https://Dupe.com/majority will instantly get 500 Dupe Points IndaCloud: If you're 21 or older, get 25% OFF your first order + free shipping @IndaCloud with code MAJORITY at https://inda.shop/MAJORITY! #indacloudpod Hexclad: Get 10% off at https://HexClad.com/MAJORITY Subscribe to Ravi's Substack: https://realravigupta.substack.com/ For more information visit: https://www.ravimgupta.com/analog Shout out to https://immigrantslist.org where people can donate to help get real immigration facts out! Majority 54 on Twitter: https://twitter.com/majority54 Jason on Twitter: https://twitter.com/JasonKander Jason on Instagram: https://www.instagram.com/jasonkander/ Ravi on Twitter: https://twitter.com/RaviMGupta Ravi on Instagram: https://www.instagram.com/ravimgupta Ravi on Youtube: https://www.youtube.com/@LostDebate Remember to subscribe to ALL the MeidasTouch Network Podcasts: MeidasTouch: https://www.meidastouch.com/tag/meidastouch-podcast Legal AF: https://www.meidastouch.com/tag/legal-af MissTrial: https://meidasnews.com/tag/miss-trial The PoliticsGirl Podcast: https://www.meidastouch.com/tag/the-politicsgirl-podcast The Influence Continuum: https://www.meidastouch.com/tag/the-influence-continuum-with-dr-steven-hassan Mea Culpa with Michael Cohen: https://www.meidastouch.com/tag/mea-culpa-with-michael-cohen The Weekend Show: https://www.meidastouch.com/tag/the-weekend-show Burn the Boats: https://www.meidastouch.com/tag/burn-the-boats Majority 54: https://www.meidastouch.com/tag/majority-54 Political Beatdown: https://www.meidastouch.com/tag/political-beatdown On Democracy with FP Wellman: https://www.meidastouch.com/tag/on-democracy-with-fpwellman Uncovered: https://www.meidastouch.com/tag/maga-uncovered Learn more about your ad choices. Visit megaphone.fm/adchoices

ThePrintUninterrupted: Is Sanchar Saathi app the solution to cyber crime? Apar Gupta explains privacy concerns

solution gupta cybercrime founder director apar privacy concerns saathi internet freedom foundation

Play Episode Listen Later Dec 4, 2025 19:31

On Wednesday, the government withdrew a mandate requiring smartphone makers to preload the Sanchar Saathi on all new devices. Several privacy advocates had raised concerns over how the app may impact users' rights. But is the app the answer to the increasing cyber crime in the country? And how does the app impact citizens' privacy? Founder-Director of Internet Freedom Foundation, Apar Gupta explains, in conversation with Senior Assistant Editor, Apoorva Mandhani.

Cancer FOMO with Saranne

Beating Cancer Daily with Saranne Rothberg ~ Stage IV Cancer Survivor

Play Episode Listen Later Dec 4, 2025 16:16

Today on Beating Cancer Daily, Saranne explores the concept of FOMO, Fear of Missing Out, and how it uniquely affects cancer patients. Drawing from personal experiences and referencing a 2021 study from the World Journal of Clinical Cases by Gupta and Sharma, Saranne explains how FOMO can lead to anxiety, disrupted sleep, and emotional issues, especially when compounded by the rigorous demands of cancer treatment. She emphasizes the importance of self-preservation and introduces the concept of JOMO (Joy of Missing Out) as a healthier mindset. By creating an inner life filled with joy, one doesn't need to keep up with social expectations and can instead focus on what truly brings peace and happiness. "Forget others, me only." – Saranne Today on Beating Cancer Daily: · FOMO stands for Fear of Missing Out, and social media often exacerbates it.· A 2021 study identified multiple negative impacts of FOMO, including anxiety and reduced physical well-being.· For cancer patients, FOMO can add unnecessary stress during treatment, making it crucial to manage social engagements wisely.· JOMO — Joy of Missing Out — is about finding contentment in one's inner life rather than external activities.· Self-preservation is key during cancer treatment; knowing when to rest and recharge is vital.· Practical strategies for combating FOMO include journaling, meditation, and turning off social media.· Scheduling social connections via digital means can help maintain relationships without the physical strain of going out.· Tools like ComedyCures LaughLine offer daily humor, aiding in emotional well-being. Resources Mentioned:ComedyCures Foundationhttps://www.comedycures.org2025 People's Choice Podcast Awards Finalist Ranked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025, and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 Beating Cancer Daily is listened to in over 130 countries across 7 continents and features over 390 original daily episodes hosted by Stage IV survivor Saranne Rothberg. To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne

fear zoom drawing cancer fomo gupta sharma feedspot missing out stage iv jomo joy world journal clinical cases

Scaling Startups Globally: Key Lessons from OYO, Cars24 and Store My Goods with Sudeep Gupta

Silicon Valley Tech And AI With Gary Fowler

Play Episode Listen Later Dec 4, 2025 26:05

Join Sudeep Gupta, Founder and CEO of Store My Goods, in an insightful conversation with Gary Fowler as they explore what it really takes to build, scale, and globalize high-growth startups. With a career spanning leadership roles at OYO and Cars24 — and now building a fast-growing, tech-enabled storage solutions company — Sudeep brings rare, firsthand experience from both early-stage ventures and large-scale operational expansion across the globe.

E64: Reinventing How Teams Find Talent with Ishan Gupta (Juicebox)

Partner Path

Play Episode Listen Later Dec 3, 2025 29:23

This week, we're joined by Ishan Gupta, co-founder of Juicebox — a company redefining how recruiting works in an AI-native world.Ishan shares how they pivoted from earlier ideas to focus on the highest value part of hiring: identifying the right people and getting them into process. With Juicebox, you describe what you want in natural language and the platform searches more than 800 million professional profiles, surfaces the best matches, and engages candidates through recruiting agents.Their breakout feature, Autopilot, uses LLMs to semantically evaluate and stack rank candidates based on nuanced criteria, which quickly drove organic growth and strong PMF. We talk about why their data makes the product so sticky, how they see recruiting evolving over the next five years, what led them to raise their Series A, and the culture they are building around moving fast and being intellectually honest.Ishan also shares what they are building next with their memory layer, which will make it clear what the AI is learning over time and how it improves future searches.Episode chapters:1:44 - Competitive programming4:35 - Choosing the company name5:55 - YC and the pivot8:00 - How Juicebox differs from traditional recruiting9:51 - The killer feature14:30 - What makes the product sticky17:15 - Is recruiting a zero sum game19:10 - The macro view of hiring22:05 - Raising a later Series A24:10 - Product expansion26:45 - Quick fire round This episode is brought to you by Grata, the leading deal sourcing platform for private equity. Grata's AI powered search, investment grade data, and intuitive workflows help you find and win the right deals faster. Visit grata.com to book a demo.This episode is also sponsored by Overlap, the AI powered app that uses LLMs to surface the best moments from any podcast. Overlap reads full transcripts, finds the most relevant clips, and stitches them into a personalized stream of insights. Tap into podcasts as a real information source with Overlap 2.0, now available on the App Store.

ai talent raising product tap competitive app store reinventing autopilot gupta yc overlap juicebox pmf ishan

Driving Impact Beyond the Bedside with Vin Gupta, MD, MPA

Infectious IDeas

Play Episode Listen Later Dec 3, 2025 25:37

Send us a textIn this episode, Vin Gupta, MD, MPA, a pulmonary and critical care physician and medical analyst with NBC News and MSNBC, joins hosts Marla Dalton, CAE, and William Schaffner, MD, for a compelling conversation about his path from the intensive care unit to the national stage, and why creating impact beyond the bedside has become his mission. From confronting misinformation to advancing early detection and bridging health, technology, and policy, Gupta shares candid insights on leadership, effective communication, and the future of public health. A fond farewell to our current hosts—Marla Dalton and Bill Schaffner—in this final episode before new hosts join the podcast. Show NotesAs managing director of healthcare innovation at Manatt, Gupta is a leading expert bridging the worlds of clinical care, technology, and effective communication. He previously served in several roles at Amazon and Google, is a Major in the US Air Force Reserve, and has earned degrees from Princeton, Columbia, Harvard, and the University of Cambridge. Gupta is a life member of the Council on Foreign Relations and serves on the National Board of Directors of the American Lung Association. He currently lives in Seattle, WA, with his wife, who is a practicing pediatrician, and their 2 young boys. Follow NFID on social media

Introduction to The Visibility Equation with Surbhi Gupta

Women In Product

Play Episode Listen Later Dec 2, 2025 20:21

The Visibility Equation is a weekly podcast series that demystifies the art of professional visibility. It is designed to empower ambitious product leaders (and leaders across tech) to own their narratives and amplify their impact. Through in-depth conversations with accomplished leaders in product management, design, and engineering, we'll delve into practical strategies, inspiring stories, and actionable insights to help listeners build visibility without falling into the “humble brag” trap.00:00 Introduction to The Visibility Equation01:25 The Importance of Visibility02:59 Surbhi's Personal Journey06:59 Strategies for Building Visibility11:25 Why Visibility Matters Now14:55 About the Interviews18:20 First Episode PreviewResources•

women community strategy visibility gupta equation surbhi

Revolutionizing Healthy Snacking: Atul Gupta, Founder & CEO of Bonvie Snacks

The Brand Called You

Play Episode Listen Later Dec 2, 2025 26:25

Welcome to another inspiring episode of The Brand Called You! In this conversation, host Ashutosh Garg sits down with Atul Gupta, Founder and CEO of Bonvie Snacks, to explore his remarkable journey from finance and energy to healthy food entrepreneurship. Discover the innovative freeze-drying technology Bonvie is using, how they're bridging the gap between taste and health, and their commitment to sustainability and empowering farmers.Atul Gupta shares the challenges of building a food brand in India's competitive snacking market, how Bonvie differentiates itself, and what it takes to scale quickly both online and offline. Gain valuable insights into the evolving landscape of healthy snacking, supply chain tech, and the future of consumer behavior. Whether you're an aspiring entrepreneur or a health-conscious consumer, this episode offers valuable lessons and an inside look at the booming snacking industry!

ceo founders discover healthy snacks founder ceo revolutionizing gupta snacking atul

How to Identify Medical Misinformation & Fake AI Ads

Coronavirus: Fact vs Fiction

Play Episode Listen Later Nov 28, 2025 27:41

As a practicing neurosurgeon and CNN's chief medical correspondent, Dr. Sanjay Gupta can spot false health claims from a mile away. Still, he recently became the unwitting subject of an AI disinformation campaign that used his likeness to sell sham health products. On today's episode, Dr. Gupta shares what happened, and offers tips to avoid getting duped by medical misinformation online. Learn more about your ad choices. Visit podcastchoices.com/adchoices

ai cnn medical identify misinformation gupta sanjay gupta fake ai

SPOTLIGHT on Vinita Gupta and "The Woman In Deed"

Trust Me...I Know What I'm Doing

Play Episode Listen Later Nov 25, 2025 29:21

Periodically on Trust Me, I Know What I'm Doing, we share a SPOTLIGHT conversation and feature brief chats with an individual from the community about a very special topic or a unique endeavor. Now, we live in an era where lessons and memory of the past seems to get crystallized and presented with increasing speed and accuracy. But perhaps now more than ever, it's equally important to actually pause and reflect and synthesize and process our experiences as rich human lessons to share and express to the world. Vinita Gupta is a pioneering entrepreneur and technology leader who made history as the first woman of Indian origin to take a company public in the US. With over 40 years in Silicon Valley, she's a celebrated leader in engineering and innovation, and a staunch advocate for women in tech. To add to that, Vinita is an internationally recognized bridge champion, an artist, and a writer. And she recently wrote about her multifaceted journey in her memoir, The Woman Indeed: Road to IPO, Bridge Tables, and Beyond, which is available everywhere.Big shout out to INDIASPORA for sparking this one, to anyone who is sick of the six seven trend, to the American South Asian Network at americansouthasiannetwork.comIt's Thanksgiving week in the US, so please, find someone in need and consciously practice a random act of kindness!

thanksgiving leadership woman entrepreneurship indian mindfulness silicon valley vulnerability mentorship memoir ipo spotlight deeds women in tech south asian gupta comit indian americans periodically

S2E15: Morpho-ing the world of crypto lending with Merlin Egalite

The Crypto Explorer - by Sygnum Bank AG

Play Episode Listen Later Nov 25, 2025 33:23

In Sygnum's latest episode of The Crypto Explorer Podcast, host Aliya das Gupta speaks with Merlin Egalite, co-founder of Morpho, about how the protocol is reshaping lending in DeFi. They discuss:▪️ The origins of Morpho as a student project and the launch of Optimizer ▪️ How Optimizer reduced inefficiencies by offering better rates for both lenders and borrowers ▪️ The transition to Morpho V1 – building a permissionless, immutable infrastructure to solve trust and governance issues ▪️ What's coming with Morpho V2: fixed-rate lending and more efficient liquidity use ▪️ Why simplicity, security and audits are critical for institutional adoption ▪️ Real-world integrations with fintechs, banks and exchanges like CoinbaseRead the disclaimer here: https://www.sygnum.com/disclaimer

real finance bitcoin crypto ethereum lending gupta merlin defi morpho egalite sygnum

A Third on the Shelf: Rethinking Power in Community Research

Health Hats, the Podcast

Play Episode Listen Later Nov 24, 2025

Kirk & Lacy on shifting research funding away from federal grants: what happens to community partnerships when the money—and the rules—change? Summary Three Audiences, One Report Lacy Fabian and Kirk Knestis untangle a fundamental confusion in community health research: there are three distinct audiences with competing needs—funders want accountability, researchers want generalizable knowledge, and communities want immediate benefit. Current practice optimizes for the funder, producing deliverables that don’t help the people being served. The alternative isn’t “no strings attached” anarchy but rather honest negotiation about who benefits and who bears the burden of proof. Kirk’s revelation about resource allocation is stark: if one-third of evaluation budgets goes to Click here to view the printable newsletter with images. More readable than a transcript. Contents Table of Contents Toggle EpisodeProem1. Introductions & Career Transitions2. The Catalyst: Why This Conversation Matters3. The Ideal State: Restoring Human Connection4. The Localization Opportunity5. Evidence + Story = Impact6. The Funder Issue: Who Is This Truly Benefiting?7. Dissemination, Implementation & Vested Interest8. Data Parties – The Concrete Solution9. No Strings Attached: Reimagining Funder Relationships10. Balancing Accountability and Flexibility11. Where the Money Actually Goes12. The Pendulum Swings13. The Three Relationships: Funder, Researcher, Community14. Maintaining Agency15. Listen and LearnReflectionRelated episodes from Health Hats Please comment and ask questions: at the comment section at the bottom of the show notes on LinkedIn via email YouTube channel DM on Instagram, TikTok to @healthhats Substack Patreon Production Team Kayla Nelson: Web and Social Media Coach, Dissemination, Help Desk Leon van Leeuwen: editing and site management Oscar van Leeuwen: video editing Julia Higgins: Digit marketing therapy Steve Heatherington: Help Desk and podcast production counseling Joey van Leeuwen, Drummer, Composer, and Arranger, provided the music for the intro, outro, proem, and reflection Claude, Perplexity, Auphonic, Descript, Grammarly, DaVinci Podcast episode on YouTube Inspired by and Grateful to: Ronda Alexander, Eric Kettering, Robert Motley, Liz Salmi, Russell Bennett Photo Credits for Videos Data Party image by Erik Mclean on Unsplash Pendulum image by Frames For Your Heart on Unsplash Links and references Lacy Fabian, PhD, is the founder of Make It Matter Program Consulting and Resources (makeitmatterprograms.com). She is a research psychologist with 20+ years of experience in the non-profit and local, state, and federal sectors who uses evidence and story to demonstrate impact that matters. She focuses on helping non-profits thrive by supporting them when they need it—whether through a strategy or funding pivot, streamlining processes, etc. She also works with foundations and donors to ensure their giving matters, while still allowing the recipient non-profits to maintain focus on their mission. When she isn't making programs matter, she enjoys all things nature —from birdwatching to running —and is an avid reader. Lacy Fabian’s Newsletter: Musings That Matter: Expansive Thinking About Humanity’s Problems Kirk Knestis is an expert in data use planning, design, and capacity building, with experience helping industry, government, and education partners leverage data to solve difficult questions. Kirk is the Executive Director of a startup community nonprofit that offers affordable, responsive maintenance and repairs for wheelchairs and other personal mobility devices to northern Virginia residents. He was the founding principal of Evaluand LLC, a research and evaluation consulting firm providing customized data collection, analysis, and reporting solutions, primarily serving clients in industry, government, and education. The company specializes in external evaluation of grant-funded projects, study design reviews, advisory services, and capacity-building support to assist organizations in using data to answer complex questions. Referenced in episode Zanakis, S.H., Mandakovic, T., Gupta, S.K., Sahay, S., & Hong, S. (1995). “A review of program evaluation and fund allocation methods within the service and government sectors.” Socio-Economic Planning Sciences, Vol. 29, No. 1, March 1995, pp. 59-79. This paywalled article presents a detailed analysis of 306 articles from 93 journals that review project/program evaluation, selection, and funding allocation methods in the service and government sectors. Episode Proem When I examine the relationships between health communities and researchers, I become curious about the power dynamics involved. Strong, equitable relationships depend on a balance of power. But what exactly are communities, and what does a power balance look like? The communities I picture are intentional, voluntary groups of people working together to achieve common goals—such as seeking, fixing, networking, championing, lobbying, or communicating for best health for each other. These groups can meet in person or virtually, and can be local or dispersed. A healthy power balance involves mutual respect, participatory decision-making, active listening, and a willingness to adapt and grow. I always listen closely for connections between communities and health researchers. Connections that foster a learning culture, regardless of their perceived success. Please meet Lacy Fabian and Kirk Knestis, who have firsthand experience in building and maintaining equitable relationships, with whom I spoke in mid-September. This transcript has been edited for clarity with help from Grammarly. Lacy Fabian, PhD, is the founder of Make It Matter Program Consulting and Resources. She partners with non-profit, government, and federal organizations using evidence and storytelling to demonstrate impact and improve program results. Kirk Knestis is an expert in data use planning, design, and capacity building. As Executive Director of a startup community nonprofit and founding principal of Evaluand LLC. He specializes in research, evaluation, and organizational data analysis for complex questions. 1. Introductions & Career Transitions Kirk Knestis: My name’s Kirk Knestis. Until just a few weeks ago, I ran a research and evaluation consulting firm, Evaluand LLC, outside Washington, DC. I’m in the process of transitioning to a new gig. I’ve started a non-profit here in Northern Virginia to provide mobile wheelchair and scooter service. Probably my last project, I suspect. Health Hats: Your last thing, meaning you’re retiring. Kirk Knestis: Yeah, it’s most of my work in the consulting gig was funded by federal programs, the National Science Foundation, the Department of Ed, the National Institutes of Health, and funding for most of the programs that I was working on through grantees has been pretty substantially curtailed in the last few months. Rather than looking for a new research and evaluation gig, we’ve decided this is going to be something I can taper off and give back to the community a bit. Try something new and different, and keep me out of trouble. Health Hats: Yeah, good luck with the latter. Lacy, introduce yourself, please. Lacy Fabian: Hi, Lacy Fabian. Not very dissimilar from Kirk, I’ve made a change in the last few months. I worked at a large nonprofit for nearly 11 years, serving the Department of Health and Human Services. But now I am solo, working to consult with nonprofits and donors. The idea is that I would be their extra brain power when they need it. It’s hard to find funding, grow, and do all the things nonprofits do without a bit of help now and then. I’m looking to provide that in a new chapter, a new career focus. Health Hats: Why is this conversation happening now? Both Kirk and Lacy are going through significant changes as they move away from traditional grant-funded research and nonprofit hierarchies. They’re learning firsthand what doesn’t work and considering what might work instead—this isn't just theory—it’s lived experience. 2. The Catalyst: Why This Conversation Matters Health Hats: Lacy, we caught up after several years of working together on several projects. I’m really interested in community research partnerships. I’m interested in it because I think the research questions come from the communities rather than the researchers. It’s a fraught relationship between communities and researchers, often driven by power dynamics. I’m very interested in how to balance those dynamics. And I see some of this: a time of changing priorities and people looking at their gigs differently —what are the opportunities in this time of kind of chaos, and what are the significant social changes that often happen in times like this? 3. The Ideal State: Restoring Human Connection Health Hats: In your experience, especially given all the recent transitions, what do you see as the ideal relationship between communities and researchers? What would an ideal state look like? Lacy Fabian: One thing I was thinking about during my walk or run today, as I prepared for this conversation about equitable relationships and the power dynamics in this unique situation we’re in, is that I feel like we often romanticize the past instead of learning from it. I believe learning from the past is very important. When I think about an ideal scenario, I feel like we’re moving further away from human solidarity and genuine connection. So, when considering those equitable relationships, it seems to me that it’s become harder to build genuine connections and stay true to our humanness. From a learning perspective, without romanticizing the past, one example I thought of is that, at least in the last 50 years, we’ve seen exponential growth in the amount of information available. That's a concrete example we can point to. And I think that we, as a society, have many points where we could potentially connect. But recent research shows that’s not actually the case. Instead, we’re becoming more disconnected and finding it harder to connect. I believe that for our communities, even knowing how to engage with programs like what Kirk is working on is difficult. Or even in my position, trying to identify programs that truly want to do right, take that pause, and make sure they aim to be equitable—particularly on the funder side—and not just engage in transactions or give less generously than they intend if they’re supporting programs. But there are strings attached. I think all of this happens because we stop seeing each other as human beings; we lose those touchpoints. So, when I think about an ideal situation, I believe it involves restoring those connections, while more clearly and openly acknowledging the power dynamics we introduce and the different roles we assume in the ecosystem. We can’t expect those dynamics to be the same, or to neutralize their impact. However, we can discuss these issues more openly and consistently and acknowledge that they might influence outcomes. So, in an ideal scenario, these are the kinds of things we should be working toward. 4. The Localization Opportunity Health Hats: So Kirk, it strikes me listening to Lacy talk that there’s, in a way, the increased localization of this kind of work could lead to more relationships in the dynamic, whereas before, maybe it was. Things were too global. It was at an academic medical center and of national rather than local interest. What are your thoughts about any of that? Kirk Knestis: Yeah, that’s an excellent question. First, I want to make sure I acknowledge Lacy’s description philosophically, from a value standpoint. I couldn’t put it any better myself. Certainly, that’s got to be at the core of this. Lacy and I know each other because we both served on the board of the Professional Evaluation Society on the East Coast of the United States, and practice of evaluation, evaluating policies and programs, and use of resources, and all the other things that we can look at with evidence, the root of that word is value, right? And by making the values that drive whatever we’re doing explicit, we’re much more likely to connect. At levels in, way, in ways that are actually valuable, a human being level, not a technician level. But to your question, Danny, a couple of things immediately leap out at me. One is that there was always. I was primarily federally funded, indirectly; there’s always been a real drive for highly rigorous, high-quality evaluation. And what that oftentimes gets interpreted to mean is generalizable evaluation research. And so that tends to drive us toward quasi-experimental kinds of studies that require lots and lots of participants, validated instrumentation, and quantitative data. All of those things compromise our ability to really understand what’s going on for the people, right? For the real-life human stakeholders. One thing that strikes me is that we could be as funding gets picked up. I’m being optimistic here that funding will be picked up by other sources, but let’s say the nonprofits get more involved programs that in the past and in the purview of the feds, we’re going to be freed of some of that, I hope, and be able to be more subjective, more mixed methods, more on the ground and kind of maturein the, dirt down and dirty out on the streets, learning what’s going on for real humans. As opposed to saying, “Nope, sorry, we can’t even ask whether this program works or how it works until we’ve got thousands and thousands of participants and we can do math about the outcomes.” So that’s one way I think that things might be changing. 5. Evidence + Story = Impact One of the big elements I like to focus on is the evidence—the kind of, so what the program is doing—but also the story. Making sure both of those things are combined to share the impact. And one of the things that I think we aren’t great about, which kind of circles back to the whole topic about equitable relationships. I don’t often think we’re really great at acknowledging. Who our report outs are for 6. The Funder Issue: Who Is This Truly Benefiting? Health Hats: Yes, who’s the audience? Lacy Fabian: Describing the kind of traditional format, I’m going to have thousands of participants, and then I’m going to be able to start to do really fancy math. That audience is a particular player who’s our funder. And they have different needs and different goals. So so many times, but that’s not the same as the people we’re actually trying to help. I think part of actually having equity in practice is pushing our funders to acknowledge that those reports are really just for them. And what else are we doing for our other audiences, and how can we better uphold that with our limited resources? Do we really need that super fancy report that’s going to go on a shelf? And we talk about it a lot, but I think that’s the point. We’re still talking about it. And maybe now that our funding is shifting, it’s an excellent catalyst to start being smarter about who our audience is, what they need, and what’s best to share with them. 7. Dissemination, Implementation & Vested Interest Health Hats: So, in a way, that’s not only do we need to think about who the work is for. How do we get it to those people? So how do we disseminate to those people? And then, what are the motivations for implementation? And it seems to me that if I have a vested interest in the answer to the question, I am more likely to share it and to try to figure out what the habits are—the changing habits that the research guides. What are some examples of this that you’ve, in your experience, that either you feel like you hit it like this, worked, or where you felt like we didn’t quite get there? So, what are your thoughts about some practical examples of that? Kirk Knestis: I was laughing because I don’t have so many examples of the former. I’ve got lots of examples of the latter. Health Hats: So start there. 8. Data Parties – The Concrete Solution Kirk Knestis: A good example of how I’ve done that in the past is when clients are willing to tolerate it. We call them different things over the years, like a data party. What we do is convene folks. We used to do it in person, face-to-face, but now that we’re dealing with people spread out across the country and connected virtually, these meetings can be done online. Instead of creating a report that just sits on a shelf or a thumb drive, I prefer to spend that time gathering and organizing the information we collect into a usable form for our audiences. This acts as a formative feedback process rather than just a summative benchmark. Here’s what we’ve learned. You share the information with those who contributed to it and benefit from it, and you ask for their thoughts. We’re observing that this line follows a certain path. Let’s discuss what that means or review all the feedback we received from this stakeholder group. It’s quite different from what we’ve heard from other stakeholders. What do you think is happening there? And let them help add value to the information as it moves from evidence to results. Health Hats: This is the solution to the funder problem. Instead of writing reports for funders, Kirk brings together the actual stakeholders—the people who provided data and benefit from the program. They assist in interpreting the findings in real-time. It’s formative, not summative. It’s immediate, not shelved. 9. No Strings Attached: Reimagining Funder Relationships Health Hats: I think it’s interesting that a thread through this is the role of the funder and the initiative’s governance. I remember that we worked on a couple of projects. I felt like the funder’s expectations were paramount, and the lessons we learned in the process were less important, which aligns with what we didn’t show. Publication bias or something. Sometimes in these initiatives, what’s most interesting is what didn’t work —and that’s not so, anyway. So how? So now that you’re looking forward to working with organizations that are trying to have questions answered, how is that shaping how you’re coaching about governance of these initiatives? Like, where does that come in? Lacy Fabian: Yeah. I think, if we’re talking about an ideal state, there are models, and it will be interesting to see how many organizations really want to consider it, but the idea of no-strings-attached funding. Doesn’t that sound nice, Kirk? The idea being that if you are the funding organization and you have the money, you have the power, you’re going to call the shots. In that way, is it really fair for you to come into an organization like something that Kirk has and start dictating the terms of that money? So, Kirk has to start jumping through the hoops of the final report and put together specific monthly send-ins for that funder. And he has to start doing these things well for that funder. What if we considered a situation where the funder even paid for support to do that for themselves? Maybe they have somebody who comes in, meets with Kirk, or just follows around, shadows the organization for a day or so, collects some information, and then reports it back. But the idea is that the burden and the onus aren’t on Kirk and his staff. Because they’re trying to repair wheelchairs and imagining the types of models we’ve shifted. We’ve also left the power with Kirk and his organization, so they know how to serve their community best. Again, we’ve put the onus back on the funder to answer their own questions that are their needs. I think that’s the part that we’re trying to tease out in the equity: who is this really serving? And if I’m giving to you, but I’m saying you have to provide me with this in return. Again, who’s that for, and is that really helping? Who needs their wheelchair service? And I think that’s the part we need to work harder at unpacking and asking ourselves. When we have these meetings, put out these funding notices, or consider donating to programs, those are the things we have to ask ourselves about and feel are part of our expectations. 10. Balancing Accountability and Flexibility Health Hats: Wow. What’s going through my mind is, I’m thinking, okay, I’m with PCORI. What do we do? We want valuable results. We do have expectations and parameters. Is there an ideal state? Those tensions are real and not going away. But there’s the question of how to structure it to maximize the value of the tension. Oh, man, I’m talking abstractly. I need help thinking about the people who are listening to this. How does somebody use this? So let’s start with: for the researcher? What’s the mindset that’s a change for the researcher? What’s the mindset shift for the people, and for the funder? Let’s start with the researcher. Either of you pick that up. What do you think a researcher needs to do differently? Kirk Knestis: I don’t mind having opinions about this. That’s a fascinating question, and I want to sort of preface what I’m getting ready to say. With this, I don’t think it’s necessary to assume that, to achieve the valuable things Lacy just described, we must completely abrogate all responsibility. I think it would be possible for someone to say, money, no strings attached. We’re never going to get the board/taxpayer/or whoever, for that. Importantly, too, is to clarify a couple of functions. I found that there are a couple of primary roles that are served by the evaluation or research of social services or health programs, for example. The first and simplest is the accountability layer. Did you do what you said you were going to do? That’s operational. That doesn’t take much time or energy, and it doesn’t place a heavy burden on program stakeholders. Put the burden on the program’s managers to track what’s happening and be accountable for what got done. Health Hats: So like milestones along the way? Kirk Knestis: Yes. But there are other ways, other dimensions to consider when we think about implementation. It’s not just the number of deliveries but also getting qualitative feedback from the folks receiving the services. So, you can say, yeah, we were on time, we had well-staffed facilities, and we provided the resources they needed. So that’s the second tier. The set of questions we have a lot more flexibility with at the next level. The so-what kind of questions, in turn, where we go from looking at this term bugs me, but I’ll use it anyway. We’re looking at outputs—delivery measures of quantities and qualities—and we start talking about outcomes: persistent changes for the stakeholders of whatever is being delivered. Attitudes, understandings. Now, for health outcomes—whatever the measures are—we have much more latitude. Focus on answering questions about how we can improve delivery quality and quantity so that folks get the most immediate and largest benefit from it. And the only way we can really do that is with a short cycle. So do it, test it, measure it, improve it. Try it again, repeat, right? So that formative feedback, developmental kind of loop, we can spend a lot of time operating there, where we generally don’t, because we get distracted by the funder who says, “I need this level of evidence that the thing works, that it scales.” Or that it demonstrates efficacy or effectiveness on a larger scale to prove it. I keep wanting to make quotas, right, to prove that it works well. How about focusing on helping it work for the people who are using it right now as a primary goal? And that can be done with no strings attached because it doesn’t require anything to be returned to the funder. It doesn’t require that deliverable. My last thought, and I’ll shut up. 11. Where the Money Actually Goes Kirk Knestis: A study ages ago, and I wish I could find it again, Lacy. It was in one of the national publications, probably 30 years ago. Health Hats: I am sure Lacy’s going to remember that. Kirk Knestis: A pie chart illustrated how funds are allocated in a typical program evaluation, with about a third going to data collection and analysis, which adds value. Another third covers indirect costs, such as keeping the organization running, computers, and related expenses. The remaining third is used to generate reports, transforming the initial data into a tangible deliverable. If you take that third use much more wisely, I think you can accomplish the kind of things Lacy’s describing without, with, and still maintain accountability. Health Hats: This is GOLD. The 1/3: 1/3: 1/3 breakdown is memorable, concrete, and makes the problem quantifiable. Once again, 1/3 each for data collection and analysis, keeping the organization alive, and writing reports. 12. The Pendulum Swings Lacy Fabian: And if I could add on to what Kirk had said, I think one of the things that comes up a lot in the human services research space where I am is this idea of the pendulum swing. It’s not as though we want to go from a space where there are a lot of expectations for the dollars, then swing over to one where there are none. That’s not the idea. Can we make sure we’re thinking about it intentionally and still providing the accountability? So, like Kirk said, it’s that pause: do we really need the reports, and do we really need the requirements that the funder has dictated that aren’t contributing to the organization’s mission? In fact, we could argue that in many cases, they’re detracting from it. Do we really need that? Or could we change those expectations, or even talk to our funder, as per the Fundee, to see how they might better use this money if they were given more freedom, not to have to submit these reports or jump through these hoops? And I believe that’s the part that restores that equity, too, because it’s not the funder coming in and dictating how things will go or how the money will be used. It’s about having a relational conversation, being intentional about what we’re asking for and how we’re using the resources and then being open to making adjustments. And sometimes it’s just that experimentation: I think of it as, we’re going to try something different this time, we’re going to see if it works. If it doesn’t work, it probably won’t be the end of the world. If it does, we’ll probably learn something that will be helpful for next time. And I think there’s a lot of value in that as well. Health Hats: Lacy’s ‘pendulum swing’ wisdom: not anarchy, but intentional. Not ‘no accountability’ but ‘accountability without burden-shifting.’ The move is from the funder dictating requirements to relational conversation. And crucially: willingness to experiment. 13. The Three Relationships: Funder, Researcher, Community Health Hats: Back to the beginning—relationships. So, in a way, we haven’t really —what we’ve talked about is the relationship with funders. Lacy Fabian: True. Health Hats: What is the relationship between researchers and the community seeking answers? We’re considering three different types of relationships. I find it interesting that people call me about their frustrations with the process, and I ask, “Have you spoken with the program officer?” Have you discussed the struggles you’re facing? Often, they haven’t or simply don’t think to. What do you think they’re paid for? They’re there to collaborate with you. What about the relationships between those seeking answers and those studying them—the communities and the researchers? How does that fit into this? Kirk Knestis: I’d like to hear from Lacy first on this one, because she’s much more tied into the community than the communities I have been in my recent practices. 14. Maintaining Agency Health Hats: I want to wrap up, and so if. Thinking about people listening to this conversation, what do you think is key that people should take away from this that’ll, in, in either of the three groups we’ve been talking about, what is a lesson that would be helpful for them to take away from this conversation? Lacy Fabian: I think that it’s important for the individual always to remember their agency. In their engagements. And so I know when I’m a person in the audience, listening to these types of things, it can feel very overwhelming again to figure out what’s enough, where to start, and how to do it without making a big mistake. I think that all of those things are valid. Most of us in our professional lives who are likely listening to this, we show up at meetings, we take notes. We’re chatting with people, engaging with professional colleagues, or connecting with the community. And I think that we can continue to be intentional with those engagements and take that reflective pause before them to think about what we’re bringing. So if we’re coming into that program with our research hat on, or with our funder hat on, what are we bringing to the table that might make it hard for the person on the other side to have an equitable conversation with us? If you’re worried about whether you’ll be able to keep your program alive and get that check, that’s not a balanced conversation. And so if you are the funder coming in, what can you do to put that at ease or acknowledge it? Suppose you are the person in the community who goes into someone’s home and sees them in a really vulnerable position, with limited access to healthcare services or the things they need. What can you do to center that person, still like in their humanity, and not just this one problem space? And that they’re just this problem because that’s, I think, where we go astray and we lose ourselves and lose our solidarity and connection. So I would just ask that people think about those moments as much as they can. Obviously, things are busy and we get caught up, but finding those moments to pause, and I think it can have that snowball effect in a good way, where it builds and we see those opportunities, and other people see it and they go, Huh, that was a neat way to do it. Maybe I’ll try that too. 15. Listen and Learn Health Hats: Thank you. Kirk. Kirk Knestis: Yeah. A hundred percent. I’m having a tough time finding anything to disagree with what Lacy is sharing. And so I’m tempted just to say, “Yeah, what Lacy said.” But I think it’s important that, in addition to owning one’s agency and taking responsibility for one’s own self, one stands up for one’s own interests. At the same time, that person has to acknowledge that everybody else knows that the three legs of that stool I described earlier have to do the same thing, right? Yeah. So, it’s about a complicated social contract among all those different groups. When the researchers talk to the program participant, they must acknowledge the value of each person’s role in the conversation. And when I, as the new nonprofit manager, am talking to funders, I’ve got to make sure I understand that I’ve got an equal obligation to stand up for my program, my stakeholders, and the ideals that are driving what I’m doing. But at the same time, similarly, respecting the commitment obligation that the funder has made. Because it never stops. The web gets bigger and bigger, right? I had a lovely conversation with a development professional at a community foundation today. And they helped me remember that they are reflecting the interests and wishes of different donor groups or individuals, and there’s got to be a lot of back-and-forth at the end of the day. I keep coming back to communication and just the importance of being able to say, okay, we’re talking about, in our case, mobility. That means this. Are we clear? Everybody’s on the same page. Okay, good. Why is that important? We think that if that gets better, these things will, too. Oh, have you thought about this thing over here? Yeah, but that’s not really our deal, right? So having those conversations so that everybody is using the same lingo and pulling in the same direction, I think, could have a significant effect on all of those relationships. Health Hats: Here’s my list from the listening agency, fear, mistake, tolerance, grace, continual Learning, communication, transparency. Kirk Knestis: and equal dollops of tolerance for ambiguity and distrust of ambiguity. Yes, there you go. I think that’s a pretty good list, Danny. Lacy Fabian: It’s a good list to live by. Health Hats: Thank you. I appreciate this. Reflection Everyone in a relationship faces power dynamics – who's in control and who's not? These dynamics affect trust and the relationship’s overall value, and they can shift from moment to moment. Changing dynamics takes mindfulness and intention. The community wanting answers, the researcher seeking evidence-based answers, and those funding the studies, have a complex relationship. Before this conversation, I focused on the community-research partnership, forgetting it was a triad, not a dyad. The Central Paradox: We have exponentially more information at our disposal for research, yet we’re becoming more disconnected. Lacy identifies this as the core problem: we’ve stopped seeing each other as human beings and lost the touchpoints that enable genuine collaboration—when connection matters most. This is true for any relationship. The Hidden Cost Structure Kirk’s 1/3:1/3:1/3 breakdown is golden—one-third for data collection and analysis (adds value), one-third for organizational operations, and one-third for reports (mostly shelf-ware). The key takeaway: we’re allocating one-third of resources to deliverables that don’t directly benefit the people we’re trying to help. Perhaps more of the pie could be spent on sharing and using results. Three Different “Utilities” Are Competing Kirk explains what most evaluation frameworks hide: funder utility (accountability), research utility (understanding models), and community utility (immediate benefit) are fundamentally different. Until you specify which one you’re serving, you’re likely to disappoint two of the three audiences. Data Parties Solve the Funder Problem Pragmatically. Rather than choosing between accountability and flexibility, data parties and face-to-face analysis let stakeholders interpret findings in real time – the data party. I love that visual. It’s formative, not summative. It’s relational, not transactional. The Funding Question Reverses the Power Dynamic. Currently, funders place the burden of proving impact on programs through monthly reports and compliance documentation. Lacy’s alternative is simpler: what if the funder hired someone to observe the program, gather the information, and report back? This allows the program to stay focused on its mission while the funder gains the accountability they need. But the structure shifts—the program no longer reports to the funder; instead, the funder learns from the program. That’s the difference between equity as a theory and equity as built-in. Related episodes from Health Hats Artificial Intelligence in Podcast Production Health Hats, the Podcast, utilizes AI tools for production tasks such as editing, transcription, and content suggestions. While AI assists with various aspects, including image creation, most AI suggestions are modified. All creative decisions remain my own, with AI sources referenced as usual. Questions are welcome. Creative Commons Licensing CC BY-NC-SA This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator. If you remix, adapt, or build upon the material, you must license the modified material under identical terms. CC BY-NC-SA includes the following elements: BY: credit must be given to the creator. NC: Only noncommercial uses of the work are permitted. SA: Adaptations must be shared under the same terms. Please let me know. danny@health-hats.com. Material on this site created by others is theirs, and use follows their guidelines. Disclaimer The views and opinions presented in this podcast and publication are solely my responsibility and do not necessarily represent the views of the Patient-Centered Outcomes Research Institute® (PCORI®), its Board of Governors, or Methodology Committee. Danny van Leeuwen (Health Hats)

Satya Gupta: Rising to your contribution. [CTO] [Career Notes]

The CyberWire

Play Episode Listen Later Nov 23, 2025 9:55

Please enjoy this encore of Career Notes. Co-founder and CTO of Virsec, Satya Gupta shares his story of how he has over 25 years of expertise in embedded systems, network security and systems architecture. He also talks about how a colleague of his told him something that resinated with him, he said " that was really a remarkable statement that I heard from that person. You rise to the point where you can actually contribute." He also discusses how he got into the startup atmosphere and how different scenarios in his life helped to lead him to the successful man he has become in the cyber community. We thank Satya for sharing his story. Learn more about your ad choices. Visit megaphone.fm/adchoices

career rising cto contribution gupta satya virsec

Satya Gupta: Rising to your contribution. [CTO]

Career Notes

Play Episode Listen Later Nov 23, 2025 9:55

rising cto contribution gupta satya virsec

ThePrintPod: American investigators lured Pannun plot accused Nikhil Gupta into a trap in Prague

UnHerd with Freddie Sayers

Play Episode Listen Later Nov 23, 2025 9:01

Even as he allegedly plotted with a hitman to murder Sikh separatist Gurpatwant Pannun, American investigators were luring Nikhil Gupta into a trap in Prague. --------------------------------------------------------------------------------------------- To read part 3: https://theprint.in/india/how-nikhil-gupta-walked-into-us-ambush/2788688/

american trap plot prague investigators accused gupta sikh nikhil lured

Prof. Sunetra Gupta: The lost lessons of lockdown

Play Episode Listen Later Nov 22, 2025 35:41

UnHerd's Freddie Sayers speaks with Oxford epidemiologist Professor Sunetra Gupta - one of the three primary authors of the Great Barrington Declaration - to uncover why the UK's massive £200 million COVID inquiry has produced a conclusion she calls an "insult" to the public intelligence. With the report claiming that locking down just one week earlier would have saved 23,000 lives, Gupta dismantles the modelling behind the headline and ask the questions the inquiry refused to: Why was the clear counter-evidence of Sweden ignored? And did the scientific establishment betray its own duties by choosing the certain harm of lockdown over the uncertain control of a virus? Hosted on Acast. See acast.com/privacy for more information.

covid-19 uk lost lessons lockdown prof sweden oxford acast gupta great barrington declaration sunetra gupta freddie sayers

ThePrintPod: ‘Drugs, guns & a meeting with Amanat': NYPD was watching Pannun plot accused Nikhil Gupta for 10 yrs

Play Episode Listen Later Nov 22, 2025 14:34

In the first of a three part series on the alleged RAW plot to assassinate Sikh separatist Gurpatwant Pannun, ThePrint investigates how the New York Police had maintained an incredible ten year watch on alleged RAW-linked assassin Nikhil Gupta #securitycode #GurpatwantSinghPannun #NikhilGupta --------------------------------------------------------------------------------------------- Read full article here: https://theprint.in/the-fineprint/drugs-guns-a-meeting-with-amanat-nypd-had-been-watching-pannun-plot-accused-nikhil-gupta-for-10-yrs/2786309/

guns watching drugs raw plot nypd accused gupta sikh nikhil new york police theprint

Is Trump Boxed In?

patients muscle northwestern university gupta cleveland clinic invasive potomac bcg crest meeks shilpa bladder cancer challenging cases nmibc

Play Episode Listen Later Nov 20, 2025 60:10

Ravi Gupta and Stephen Webber break down Congress's explosive vote to release the Epstein files as Trump abruptly reverses course at the last minute, raising questions about whether compromising material is being withheld. They analyze accusations from Mark Epstein that the files are already being scrubbed, Rep. Thomas Massie's threat to read names on the House floor, and the sweeping disclosure requirements included in the Epstein Files Transparency Act. Kander and Gupta also dive into the political chaos surrounding Speaker Mike Johnson's demand for last-minute changes that the Senate flatly rejected, Trump's meltdown when pressed on why he didn't release the files himself, and the escalating infighting on the right—from MTG's attacks on Trump to Megyn Kelly's soft-pedaling of Epstein's crimes to new reporting that the White House intervened on behalf of Andrew Tate. Plus, they discuss the stunning court ruling striking down Texas's redistricting maps after a DOJ-induced legal fiasco. This and more on the podcast that helps you, the majority of Americans who believe in progress, convince your conservative friends and family to join us—this is Majority 54! Hiya Health: Go to https://HiyaHealth.com/MAJORITY and get your kids the full-body nourishment they need to grow into healthy adults. Dupe: For a limited time, the first 10,000 people who go to https://Dupe.com/majority will instantly get 500 Dupe Points Found: Join thousands of small business owners simplifying their finances—open your FREE Found account now at https://found.com Hims: Thanks to HIMS! Start your free online visit today at https://hims.com/majority for your personalized ED treatment options Subscribe to Ravi's Substack: https://realravigupta.substack.com/ For more information visit: https://www.ravimgupta.com/analog Majority 54 on Twitter: https://twitter.com/majority54 Jason on Twitter: https://twitter.com/JasonKander Jason on Instagram: https://www.instagram.com/jasonkander/ Ravi on Twitter: https://twitter.com/RaviMGupta Ravi on Instagram: https://www.instagram.com/ravimgupta Ravi on Youtube: https://www.youtube.com/@LostDebate Remember to subscribe to ALL the MeidasTouch Network Podcasts: MeidasTouch: https://www.meidastouch.com/tag/meidastouch-podcast Legal AF: https://www.meidastouch.com/tag/legal-af MissTrial: https://meidasnews.com/tag/miss-trial The PoliticsGirl Podcast: https://www.meidastouch.com/tag/the-politicsgirl-podcast The Influence Continuum: https://www.meidastouch.com/tag/the-influence-continuum-with-dr-steven-hassan Mea Culpa with Michael Cohen: https://www.meidastouch.com/tag/mea-culpa-with-michael-cohen The Weekend Show: https://www.meidastouch.com/tag/the-weekend-show Burn the Boats: https://www.meidastouch.com/tag/burn-the-boats Majority 54: https://www.meidastouch.com/tag/majority-54 Political Beatdown: https://www.meidastouch.com/tag/political-beatdown On Democracy with FP Wellman: https://www.meidastouch.com/tag/on-democracy-with-fpwellman Uncovered: https://www.meidastouch.com/tag/maga-uncovered Learn more about your ad choices. Visit megaphone.fm/adchoices

Challenging Cases in Non-Muscle Invasive Bladder Cancer (NMIBC) – Drs. Shilpa Gupta & Joshua Meeks

Oncology Brothers

Play Episode Listen Later Nov 20, 2025 22:42

In this episode of the Oncology Brothers podcast, we dived deep into the rapidly evolving landscape of non-muscle invasive bladder cancer (NMIBC) treatment. Joined by expert guests Dr. Joshua Meeks, a urologist from Northwestern University, and Dr. Shilpa Gupta, a medical oncologist from Cleveland Clinic, the discussion focused on the integration of immunotherapy into non-muscle invasive bladder cancer. Key topics included: The definition and characteristics of high-risk non-muscle invasive bladder cancer. Recent clinical trials, including the CREST and POTOMAC, exploring the combination of immunotherapy with BCG treatment. The evolving role of medical oncologists in managing NMIBC and the importance of a multidisciplinary approach. Patient-centered discussions on treatment options, event-free survival, and managing side effects of immunotherapy. Join us as we unpack the latest data and real-life scenarios in NMIBC, emphasizing the critical need for collaboration between urologists and medical oncologists to improve patient outcomes. Follow us on social media: ⁠X/Twitter: https://twitter.com/oncbrothers Instagram: https://www.instagram.com/oncbrothers Website: https://oncbrothers.com/ Don't forget to like, subscribe, and check out our other episodes for more insights into the world of oncology! #NMIBC #BladderCancer #Immunotherapy #BCG #Urology #OncologyBrothers #GUCancer

FirstPersonSecondDraft: On Indira Gandhi birth anniversary: Shekhar Gupta's two meetings with ex-PM,& her successes,failures

birth failures meetings gupta successes assam chandigarh indira gandhi shekhar

Play Episode Listen Later Nov 19, 2025 11:44

On Indira Gandhi's birth anniversary, ThePrint Editor-In-Chief recalls his two meetings with the former PM. First in 1997, in Chandigarh and thereafter in February 1983 post the Nellie massacre in Assam. Watch #FirstPersonSecondDraft, where Shekhar Gupta also looks at how Indira Gandhi did brilliantly on national security through challenging years, but she had two big failures- maintaining communal peace & damaging India's political economy.

What You Need to Know About Hormone Therapy

Coronavirus: Fact vs Fiction

Play Episode Listen Later Nov 18, 2025 17:24

The FDA is planning to remove the “black box” warning from many hormone treatments for menopause -- a major shift that could change care for millions of women in this country. On this week's Paging Dr. Gupta, we break down what who this treatment could help and what you still need to know about its risks. This episode was produced by Jennifer Lai with assistance from Kyra Dahring and Leying Tang. Showrunner: Amanda Sealy Senior Producer: Dan Bloom Technical Director: Dan Dzula Executive Producer: Steve Lickteig Learn more about your ad choices. Visit podcastchoices.com/adchoices

fda hormones gupta hormone therapy paging dr

Epstein Fingers Trump

americans deep dive gupta health dr randi weingarten vin gupta

Play Episode Listen Later Nov 13, 2025 66:32

Jason Kander and Ravi Gupta break down the explosive release of newly uncovered Jeffrey Epstein emails, including messages referencing Donald Trump and Ghislaine Maxwell that raise fresh questions about what the former president knew and when. They analyze the media and political fallout, how these revelations intersect with ongoing legal scrutiny, and what Epstein's 2019 emails to journalist Michael Wolff reveal about his ties to Mar-a-Lago. Kander and Gupta also unpack the end of the government shutdown and whether Democrats “caved.” Plus, they dive into Trump's eyebrow-raising interview with Laura Ingraham on inflation, and the escalating MAGA civil war—Ben Shapiro feuding with Megyn Kelly, right-wing influencers accusing each other of betrayal, and prominent conservatives warning of a full-blown ideological collapse. This and more on the podcast that helps you, the majority of Americans who believe in progress, convince your conservative friends and family to join us—this is Majority 54! Nutrafol: Get results you can run your fingers through! For a limited time, Nutrafol is offering our listeners ten dollars off your first month's subscription and free shipping when you go to https://Nutrafol.com and enter the promo code MAJORITY. Shopify: Sign up for your one-dollar-per-month trial and start selling today at https://SHOPIFY.com/majority Dupe: For a limited time, the first 10,000 people who go to https://Dupe.com/MAJORITY will get 500 Dupe Points instantly—redeemable for gift cards, no catch. Done With Debt: Go to https://DONEWITHDEBT.com and talk with one of their specialists, FOR FREE! Majority 54 on Twitter: https://twitter.com/majority54 Jason on Twitter: https://twitter.com/JasonKander Jason on Instagram: https://www.instagram.com/jasonkander/ Ravi on Twitter: https://twitter.com/RaviMGupta Ravi on Instagram: https://www.instagram.com/ravimgupta Ravi on Youtube: https://www.youtube.com/@LostDebate Remember to subscribe to ALL the MeidasTouch Network Podcasts: MeidasTouch: https://www.meidastouch.com/tag/meidastouch-podcast Legal AF: https://www.meidastouch.com/tag/legal-af MissTrial: https://meidasnews.com/tag/miss-trial The PoliticsGirl Podcast: https://www.meidastouch.com/tag/the-politicsgirl-podcast The Influence Continuum: https://www.meidastouch.com/tag/the-influence-continuum-with-dr-steven-hassan Mea Culpa with Michael Cohen: https://www.meidastouch.com/tag/mea-culpa-with-michael-cohen The Weekend Show: https://www.meidastouch.com/tag/the-weekend-show Burn the Boats: https://www.meidastouch.com/tag/burn-the-boats Majority 54: https://www.meidastouch.com/tag/majority-54 Political Beatdown: https://www.meidastouch.com/tag/political-beatdown On Democracy with FP Wellman: https://www.meidastouch.com/tag/on-democracy-with-fpwellman Uncovered: https://www.meidastouch.com/tag/maga-uncovered Coalition of the Sane: https://meidasnews.com/tag/coalition-of-the-sane Learn more about your ad choices. Visit megaphone.fm/adchoices

Meidas Health: Dr. Gupta's Deep Dive with AFT President Randi Weingarten

The MeidasTouch Podcast

Play Episode Listen Later Nov 10, 2025 35:57

One of the nation's most influential labor leaders, Randi Weingarten, joins Dr. Vin Gupta of Meidas Health to discuss the ongoing government shutdown, its impact on healthcare access for everyday Americans, and the timely release of her new book, Why Fascists Fear Teachers. Learn more about your ad choices. Visit megaphone.fm/adchoices

Momentum

Coronavirus: Fact vs Fiction

Play Episode Listen Later Nov 6, 2025 62:35

Jason Kander and Ravi Gupta break down the Democrats' dominating victories in Virginia and New Jersey, where early returns and strong turnout have analysts like Harry Enten and Dave Wasserman predicting Democrats could be favored to retake the House in 2026. They unpack how the results exposed cracks in the GOP coalition, with MAGA influencers blaming “weak” Republican candidates and moderates pointing to Trump's shutdown chaos and record-low approval rating of -18%. Kander and Gupta also examine how Democratic leaders from Gavin Newsom to Bill Ferguson framed the victories as proof that competence and optimism still win, even as Republicans melted down online over their losses. Plus, they analyze the high-stakes Supreme Court case that could unravel Trump's global tariffs, what it means for the U.S. economy, and how it fits into a broader crisis of Trump's leadership. This and more on the podcast that helps you, the majority of Americans who believe in progress, convince your conservative friends and family to join us—this is Majority 54! Hims: Thanks to HIMS! Start your free online visit today at https://hims.com/majority for your personalized ED treatment options Hexclad: Get 10% off at https://HexClad.com/MAJORITY Support Diana and Jason Kander's November Challenge: https://secure.givelively.org/donate/veterans-community-project/diana-and-jason-kander-november-challenge-30k-in-30-days Majority 54 on Twitter: https://twitter.com/majority54 Jason on Twitter: https://twitter.com/JasonKander Jason on Instagram: https://www.instagram.com/jasonkander/ Ravi on Twitter: https://twitter.com/RaviMGupta Ravi on Instagram: https://www.instagram.com/ravimgupta Ravi on Youtube: https://www.youtube.com/@LostDebate Remember to subscribe to ALL the MeidasTouch Network Podcasts: MeidasTouch: https://www.meidastouch.com/tag/meidastouch-podcast Legal AF: https://www.meidastouch.com/tag/legal-af MissTrial: https://meidasnews.com/tag/miss-trial The PoliticsGirl Podcast: https://www.meidastouch.com/tag/the-politicsgirl-podcast The Influence Continuum: https://www.meidastouch.com/tag/the-influence-continuum-with-dr-steven-hassan Mea Culpa with Michael Cohen: https://www.meidastouch.com/tag/mea-culpa-with-michael-cohen The Weekend Show: https://www.meidastouch.com/tag/the-weekend-show Burn the Boats: https://www.meidastouch.com/tag/burn-the-boats Majority 54: https://www.meidastouch.com/tag/majority-54 Political Beatdown: https://www.meidastouch.com/tag/political-beatdown On Democracy with FP Wellman: https://www.meidastouch.com/tag/on-democracy-with-fpwellman Uncovered: https://www.meidastouch.com/tag/maga-uncovered Coalition of the Sane: https://meidasnews.com/tag/coalition-of-the-sane Learn more about your ad choices. Visit megaphone.fm/adchoices

Do Imported Organic Foods Live Up to their Labels?

Play Episode Listen Later Nov 4, 2025 16:40

Americans are buying more organic food than ever, whether it's apples from Washington or avocados from Mexico. But when that label says “organic,” especially on something grown thousands of miles away, how do you know it's truly organic? We get to the bottom of that on this week's Paging Dr. Gupta. Plus, grounding sheets claim to help with sleep and pain...but does the science back that up? This episode was produced by Jennifer Lai with assistance from Leying Tang. Showrunner: Amanda Sealy Senior Producer: Dan Bloom Technical Director: Dan Dzula Learn more about your ad choices. Visit podcastchoices.com/adchoices

washington mexico americans foods labels gupta live up organic food imported paging dr

Trump's Lowest Approval Ever