Podcasts about Gupta

Jason Kander and Ravi Gupta break down Donald Trump's escalating clash with Europe as his threats over Greenland and sweeping tariffs rattle NATO and global stability. They analyze Trump's jaw-dropping messages to European leaders, the backlash from U.S. allies and Republicans like Thom Tillis, and the growing concern that his rhetoric is pushing the alliance toward a breaking point. Kander and Gupta also dive into the domestic fallout as reports surface of potential military deployments in Minnesota, civil rights probes tied to ICE, and new polling showing Americans believe the country is spiraling out of control. Plus, they discuss Trump's record-low approval, revelations about his personal profits from the presidency, and disturbing new details about political operatives accessing voter data. This and more on the podcast that helps you, the majority of Americans who believe in progress, convince your conservative friends and family to join us—this is Majority 54! Shopify: Sign up for your one-dollar-per-month trial and start selling today at https://shopify.com/majority Cook Unity: Go to https://cookunity.com/MAJORITY54 for 50% off your first order. Thanks to CookUnity for supporting the show! Majority 54 on Instagram: https://www.instagram.com/majority_54 Majority 54 on Twitter: https://twitter.com/majority54 Jason on Twitter: https://twitter.com/JasonKander Jason on Instagram: https://www.instagram.com/jasonkander/ Ravi on Twitter: https://twitter.com/RaviMGupta Ravi on Instagram: https://www.instagram.com/ravimgupta Ravi on Youtube: https://www.youtube.com/@LostDebate Remember to subscribe to ALL the MeidasTouch Network Podcasts: MeidasTouch: https://www.meidastouch.com/tag/meidastouch-podcast Legal AF: https://www.meidastouch.com/tag/legal-af MissTrial: https://meidasnews.com/tag/miss-trial The PoliticsGirl Podcast: https://www.meidastouch.com/tag/the-politicsgirl-podcast The Influence Continuum: https://www.meidastouch.com/tag/the-influence-continuum-with-dr-steven-hassan The Weekend Show: https://www.meidastouch.com/tag/the-weekend-show Burn the Boats: https://www.meidastouch.com/tag/burn-the-boats Majority 54: https://www.meidastouch.com/tag/majority-54 On Democracy with FP Wellman: https://www.meidastouch.com/tag/on-democracy-with-fpwellman Uncovered: https://www.meidastouch.com/tag/maga-uncovered Learn more about your ad choices. Visit megaphone.fm/adchoices

On this episode of DGTL Voices, Ed interviews Sachin Gupta, CEO of IKS Health. They discuss Sachin's personal journey from India to becoming a successful healthcare leader, the mission of IKS Health in transforming healthcare delivery, and the importance of physician-led care. Sachin shares insights on leadership, the significance of sports in character building, and the value of investing in healthcare partnerships. 

In this episode of The Authority Company Podcast, Joe Pardavila sits down with Akhil Gupta, former Chairman of Blackstone India and longtime global business leader, for a wide-ranging conversation about success, meaning, and what truly shapes a fulfilling life. Akhil shares the pivotal moments that led him to walk away from some of the most sought-after roles in global business, including a near-miss during the Mumbai terrorist attacks that forced him to reevaluate how fragile life is and what matters most. That moment set him on a new path, one rooted in learning, reflection, and service. You hear why Akhil left positions defined by money, power, and prestige to study human flourishing at Harvard, what Western culture often misses about happiness, and why chasing success without meaning leaves many high achievers feeling empty. Drawing from Eastern philosophy, modern psychology, and lived experience, Akhil introduces the core idea behind his book Love, Learn, Play, a simple framework for living with purpose. The conversation explores identity beyond job titles, the danger of defining yourself by status, and how humility, gratitude, and curiosity anchor a meaningful life. Akhil also explains how play fuels creativity, why learning keeps you grounded, and how love shows up in leadership, family, and community. You will also hear about the creation of the Universal Enlightenment Forum, Akhil's mission to highlight shared human values across cultures and religions, and why focusing on common ground matters more than ever. This episode is for leaders, builders, and anyone questioning what comes after achievement, or how to build a life that feels whole instead of hollow.

Hon. Bablu Gupta is a Nepali politician and activist who became Nepal's youngest Minister of Youth and Sports, symbolizing a generational shift in governance. Known for youth representation, transparency through live-streamed meetings, and social activism, he also leads the volunteer group 100's Group.

Jason Kander and Ravi Gupta break down the fallout from Trump's Venezuela operation as the president announces an oil deal following the capture of Nicolás Maduro, raising questions about coercion, profiteering, and global backlash from China and regional allies. They analyze Trump's claims about seizing billions in Venezuelan oil, the response from interim leader Delcy Rodríguez, and mounting fears of authoritarian crackdowns as armed militias flood Caracas under a sweeping emergency decree. Kander and Gupta also dive into Trump's revived push to acquire Greenland, unpacking Marco Rubio's closed-door comments, NATO alarm, and the administration's refusal to rule out military force. Plus, they discuss new scrutiny over Epstein-related DOJ delays, fresh data showing young men souring on Trump, escalating GOP infighting, and renewed attempts to rewrite the history of January 6. This and more on the podcast that helps you, the majority of Americans who believe in progress, convince your conservative friends and family to join us—this is Majority 54! MANDO: Go to https://ShopMando.com and use code MAJORITY for 20% off sitewide plus free shipping. HIMS: Hims: Thanks to HIMS! Start your free online visit today at https://hims.com/majority for your personalized ED treatment options BRANCH: Discover unbelievably soft, responsibly made sheets from Boll & Branch and get 15% off plus free shipping at https://BollAndBranch.com/MAJORITY with code MAJORITY (exclusions apply). SMALLS: Get 60% off your first order plus free shipping at https://Smalls.com/MAJORITY54. Subscribe to Ravi's Substack: https://realravigupta.substack.com/ For more information visit: https://www.ravimgupta.com/analog Majority 54 on Twitter: https://twitter.com/majority54 Jason on Twitter: https://twitter.com/JasonKander Jason on Instagram: https://www.instagram.com/jasonkander/ Ravi on Twitter: https://twitter.com/RaviMGupta Ravi on Instagram: https://www.instagram.com/ravimgupta Ravi on Youtube: https://www.youtube.com/@LostDebate Remember to subscribe to ALL the MeidasTouch Network Podcasts: MeidasTouch: https://www.meidastouch.com/tag/meidastouch-podcast Legal AF: https://www.meidastouch.com/tag/legal-af MissTrial: https://meidasnews.com/tag/miss-trial The PoliticsGirl Podcast: https://www.meidastouch.com/tag/the-politicsgirl-podcast The Influence Continuum: https://www.meidastouch.com/tag/the-influence-continuum-with-dr-steven-hassan Mea Culpa with Michael Cohen: https://www.meidastouch.com/tag/mea-culpa-with-michael-cohen The Weekend Show: https://www.meidastouch.com/tag/the-weekend-show Burn the Boats: https://www.meidastouch.com/tag/burn-the-boats Majority 54: https://www.meidastouch.com/tag/majority-54 Political Beatdown: https://www.meidastouch.com/tag/political-beatdown On Democracy with FP Wellman: https://www.meidastouch.com/tag/on-democracy-with-fpwellman Uncovered: https://www.meidastouch.com/tag/maga-uncovered Learn more about your ad choices. Visit megaphone.fm/adchoices

Featuring perspectives from Dr Javier Cortés, Dr Rita Nanda, Prof Peter Schmid and Dr Priyanka Sharma, including the following topics:  Introduction (0:00) Case: A woman in her early 80s with multiple comorbidities and triple-negative breast cancer (TNBC) develops bone-only metastases 4 months after declining capecitabine for post-neoadjuvant residual disease — Justin Favaro, MD, PhD (1:50) Case: A woman in her mid 70s with ER-negative, HER2-low (IHC 1+), PIK3CA-mutated, PD-L1-positive metastatic breast cancer (mBC) after receiving 3 cycles of neoadjuvant paclitaxel/carboplatin/pembrolizumab, which was discontinued — Alan Astrow, MD (6:47) Previously Untreated Metastatic TNBC (mTNBC) — Prof Schmid (10:47)  Case: A woman in her early 80s with multiregimen-recurrent ER-positive, HER2-low (IHC 1+) ESR1-mutant mBC receives sacituzumab govitecan — Jennifer Yannucci, MD (27:19) Case: The role of datopotamab deruxtecan (Dato-DXd) for patients with ER-positive, HER2-low mBC who experienced disease progression on prior trastuzumab deruxtecan (T-DXd) — Ranju Gupta, MD; Case: A woman in her late 70s with bilateral recurrence in the lungs of ER-negative, HER2-low (IHC 1+) breast cancer (PD-L1 TPS 20%) receives Dato-DXd with durvalumab on protocol — Yanjun Ma, MD, PhD (31:35) Integrating Antibody-Drug Conjugates (ADCs) into the Management of Endocrine-Resistant Hormone Receptor-Positive mBC — Dr Sharma (36:31) Case: A woman in her early 70s with recurrent ER-negative, HER2-low (IHC 2+) mBC receives sacituzumab govitecan and achieves complete remission — Dr Gupta; Case: Management of neutropenia associated with sacituzumab govitecan — Gigi Chen, MD (50:30) Case: A woman in her late 60s with recurrent ER-negative, HER2-low (IHC 1+) mBC (HER2 V69L mutation) receives T-DXd and achieves a complete response but develops Grade 1 interstitial lung disease — Dr Gupta; Case: Management of T-DXd-related side effects — Laila Agrawal, MD (54:10) Selection and Sequencing of Therapy for Relapsed/Refractory mTNBC — Dr Nanda (58:59) Case: A woman in her early 40s with multiregimen-recurrent ER-positive, HER2-low mBC who has experienced severe nausea with past treatments is about to initiate T-DXd — Atif M Hussein, MD, MMM (1:12:40) Tolerability and Other Practical Considerations with ADCs and Other Cytotoxic Agents for mBC — Dr Cortés (1:18:10) CME information and select publications

Battling chronic inflammation, gut chaos, or sleep sabotage as an autistic/AuDHD/ADHD young adult?

Visibility is a superpower for leaders—but building it authentically can feel challenging. On this episode, Surbhi Gupta, host of The Visibility Equation and seasoned product leader, sits down with Lexy Franklin, CEO & Founder of Sidebar, to explore how leaders can own their narrative, amplify their impact, and connect with their authentic selves.Lexy shares practical strategies on building visibility, overcoming public speaking anxiety, nurturing relationships, and navigating the leadership journey. Together, they dive into inspiring stories, actionable insights, and the realities behind professional growth at leadership levels

Joel hosted a fun and freewheeling discussion, with a stand-out panel of readers, of our favorite books from 2025. They discuss many books that were published in 2025, but not exclusively new titles, covering a wide swath of genres from biblical studies to young adult literature to poetry. There's something in this discussion for everyone!Jessica Hooten Wilson is the Fletcher Jones Endowed Chair of Great Books at Pepperdine University ('23). She co-hosts a podcast called The Scandal of Reading, and is the author of many books, including READING FOR THE LOVE OF GOD and THE SCANDAL OF HOLINESS.Nijay K. Gupta is Julius R. Mantey Professor of New Testament at Northern Seminary. He is the cohost of the Slow Theology podcast, and author of books including TELL HER STORY, STRANGE RELIGION, and many scriptural commentaries.Dorothy Littell Greco is a writer, speaker, and photographer. Her writing has been featured in many publications including Christianity Today, Missio Alliance, and The Common Good and her most recent book is FOR THE LOVE OF WOMEN.If you'd like to order any of the following books, we encourage you to do so from Hearts and Minds Books(An independent bookstore in Dallastown, PA, run by Byron and Beth Borger) Reading for the Love of God: How to Read as a Spiritual Practice by Jessica Hooten WilsonThe Scandal of Holiness: Renewing Your Imagination in the Company of Literary Saints by Jessica Hooten WilsonTell Her Story: How Women Led, Taught & Ministered in the Early Church by Nijay GuptaStrange Religion: How the First Christians Were Weird, Dangerous & Compelling by Nijay GuptaSlow Theology: Eight Practices for Resilient Faith in a Turbulent World by Nijay Gupta & A.J. SwobodaFor the Love of Women: Uprooting and Healing Misogyny in America by Dorothy Littell GrecoThe Anti-Greed Gospel: Why the Love of Money is the Root of Racism and How the Church Can Create a New Way Forward by Malcolm FoleyRedeeming Eden: How Women in the Bible Advance the Story of Salvation by Ingrid Faro with Joyce Koo DalrympleThe Lion Women of Tehran by Marjan KamaliThe Teacher of Nomad Land by Daniel NayeriHoles by Louis SacharDo Not Judge Anyone: Desert Wisdom for a Polarized World by Isaac SlaterWhere God Happens: Discovering Christ in One Another by Rowan WilliamsJesus and the Law of Moses: The Gospels and the Restoration of Israel Within First-Century Judaism by Paul Sloan Know My Name: A Memoir by Chanel MillerYou Have a Calling: Finding Your Vocation in the True, Good & Beautiful by Karen Swallow PriorRomans: An Interpretation Bible Commentary by Susan Eastman1 Corinthians: A Theological, Pastoral & Missional Commentary by Michael GormanFor Such a Time as This: An Emergency Devotional by Hanna ReichlWhen Courage Calls: Josephine Butler and the Radical Pursuit of Justice for Women by Sarah C. WilliamsNervous Systems: Spiritual Practices to Calm Anxiety in Your Body, the Church and Politics by Sara BillupsA Pilgrimage Into Letting Go: Helping Parents and Pastors Embrace the Uncontrollable by Kara Root & Andrew RootSome of the Words are Theirs: The Art of Writing and Living a Sermon by Austic Carty

MeidasTouch host Ben Meiselas reports on Democrats demanding an immediate House hearing take place on Trump's declining health and Meiselas speaks with Dr. Gupta who shows the type to medical information that could come out at hearing on how Trump's cover up is so outrageous. Visit https://meidasplus.com for more! Remember to subscribe to ALL the MeidasTouch Network Podcasts: MeidasTouch: ⁠https://www.meidastouch.com/tag/meidastouch-podcast⁠ Legal AF: ⁠https://www.meidastouch.com/tag/legal-af⁠ MissTrial: ⁠https://meidasnews.com/tag/miss-trial⁠ The PoliticsGirl Podcast: ⁠https://www.meidastouch.com/tag/the-politicsgirl-podcast⁠ Cult Conversations: The Influence Continuum with Dr. Steve Hassan: ⁠https://www.meidastouch.com/tag/the-influence-continuum-with-dr-steven-hassan⁠ Mea Culpa with Michael Cohen: ⁠https://www.meidastouch.com/tag/mea-culpa-with-michael-cohen⁠ The Weekend Show: ⁠https://www.meidastouch.com/tag/the-weekend-show⁠ Burn the Boats: ⁠https://www.meidastouch.com/tag/burn-the-boats⁠ Majority 54: ⁠https://www.meidastouch.com/tag/majority-54⁠ Political Beatdown: ⁠https://www.meidastouch.com/tag/political-beatdown⁠ On Democracy with FP Wellman: ⁠https://www.meidastouch.com/tag/on-democracy-with-fpwellman⁠ Uncovered: ⁠https://www.meidastouch.com/tag/maga-uncovered⁠ Learn more about your ad choices. Visit megaphone.fm/adchoices

What if 2026 isn't something that happens to you—but something you intentionally design?In this solo episode, journalist and podcast host Kanika Chadda Gupta breaks down a clear, actionable system for turning vision boards into real-life results. Drawing from frameworks she's learned through The Grand Pursuit coaching and the Founders Launch Lab, Kanika shares how to move from dreaming to doing—quarter by quarter, habit by habit—without burning out. This episode is for moms and founders who want clarity, momentum, and a plan that actually works. Learn more about your ad choices. Visit megaphone.fm/adchoices

A Florida vacation meant to be a mother–daughter getaway ended in tragedy — and now pediatrician Dr. Neha Gupta is accused of killing her own child and staging it to look like a drowning. From a chilling 911 call to an autopsy that ruled out drowning, the case against Gupta has taken dramatic twists, including shifting murder charges, a bitter custody battle, bodycam footage of her arrest, and haunting video of her daughter in the days before her death. Law&Crime's Jesse Weber breaks down the timeline, the evidence, and the questions still surrounding this devastating case.PLEASE SUPPORT THE SHOW:Take your personal data back with Incogni! Use code SIDEBAR at the link below and get 60% off an annual plan: https://incogni.com/sidebarHOST:Jesse Weber: https://twitter.com/jessecordweberLAW&CRIME SIDEBAR PRODUCTION:YouTube Management - Bobby SzokeVideo Editing - Michael Deininger, Christina O'Shea, Alex Ciccarone, & Jay CruzScript Writing & Producing - Savannah Williamson & Juliana BattagliaGuest Booking - Alyssa Fisher & Diane KayeSocial Media Management - Vanessa BeinSTAY UP-TO-DATE WITH THE LAW&CRIME NETWORK:Watch Law&Crime Network on YouTubeTV: https://bit.ly/3td2e3yWhere To Watch Law&Crime Network: https://bit.ly/3akxLK5Sign Up For Law&Crime's Daily Newsletter: https://bit.ly/LawandCrimeNewsletterRead Fascinating Articles From Law&Crime Network: https://bit.ly/3td2IqoLAW&CRIME NETWORK SOCIAL MEDIA:Instagram: https://www.instagram.com/lawandcrimeTwitter: https://twitter.com/LawCrimeNetworkFacebook: https://www.facebook.com/lawandcrimeTwitch: https://www.twitch.tv/lawandcrimenetworkTikTok: https://www.tiktok.com/@lawandcrimeSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Dr. Sunil Gupta explained the complications of diabetes in simple and easily understandable language, highlighting the serious consequences of long-term uncontrolled blood sugar. He stated that persistent hyperglycaemia leads to microvascular complications such as diabetic neuropathy, retinopathy, and nephropathy, while major events like heart attack, stroke, and gangrene are associated with diseases of the large blood vessels. He described early symptoms of diabetic neuropathy, including burning sensation, numbness, tingling, and pain in the feet, and urged patients not to ignore these warning signs. Dr. Gupta clearly emphasized that diabetes control cannot be achieved by medicines alone. He stressed the importance of regular monitoring of blood glucose, HbA1c, blood pressure, cholesterol, and vitamin levels, along with avoiding wide fluctuations in blood sugar levels. He described insulin as the safest and most effective treatment for diabetes and cautioned that unnecessary delay in initiating insulin therapy can significantly increase the risk of complications. He also emphasized that before managing gangrene or planning surgery, strict control of blood sugar, blood pressure, and cholesterol, along with regular walking, quitting smoking and tobacco use, avoiding alcohol, and maintaining a disciplined lifestyle, are extremely important to improve outcomes and prevent limb loss. Expert- Dr Sunil Gupta Anchor- Mrs. Purva Kulkarni Podcast: 12/12/2025 Recorded at: Akashwani Nagpur     Episode:100

Keywords mental health, psychiatry, obstetrics, quantum theory, love, consciousness, education, spirituality, prevention, emotional well-being Summary This episode of Locked Up Living explores how two doctors from very different specialties, a psychiatrist and an obstetrician/paediatrician, came together to change the way we understand and approach mental health. Shivam Dubey and Salel Gupta share their unique journey, discussing the urgent need for preventive mental health care and the ground breaking MindSync curriculum they've developed for schools. They highlight the lack of emotional education in traditional healthcare and school systems, and reveal how their program brings evidence-based life skills, resilience training, and social-emotional learning directly to children and adults in India, Dubai, and the US.   The discussion also takes a deep dive into the relationship between love, quantum theory, and mental well-being. Drawing from both Western science and Eastern philosophy, Dr Dubey and Dr Gupta examine how consciousness and compassion can reshape the way we think about health, learning, and adversity. If you're curious about holistic approaches to wellness, or how culture, spirituality, and modern medicine intersect in the quest for better mental health, this episode brings fresh insight and practical ideas for individuals, educators, and communities. Takeaways The collaboration between psychiatry and obstetrics can enhance preventive mental health. Love has a profound impact on mental health and healing. Quantum theory offers a new perspective on spirituality and consciousness. Mental health education is crucial for children and should be formalized in schools. Self-awareness and emotional skills are essential for personal development. Adversity can be a teacher if we reflect on our experiences. Compassion should be prioritized over competition in education. The Mind-Sync curriculum aims to integrate mental health education into schools. Mighty Champions of Mental Health empowers adults to support their communities. Selfless love is a key component of emotional well-being. titles Exploring the Intersection of Love and Quantum Theory The Healing Power of Love in Mental Health Sound Bites "Love is the healing factor." "Selfless love is the ultimate goal." "Adversity is meant for you to learn." Chapters 00:00 Introduction to Dr. Dube and Dr. Gupta 02:34 The Journey of Dr. Dube and Dr. Gupta 07:29 Exploring Love and Quantum Theory 13:44 The Intersection of Science and Spirituality 26:21 The Need for Mental Health Education 31:55 Exploring Spirituality and Quantum Effects 37:21 Introducing the Mind-Sync Curriculum 43:41 Mental Health Education for All Ages 47:52 Mighty Champions of Mental Health 52:14 Self-Care and Emotional Well-Being 53:55

Keywords mental health, psychiatry, obstetrics, quantum theory, love, consciousness, education, spirituality, prevention, emotional well-being Summary This episode of Locked Up Living explores how two doctors from very different specialties, a psychiatrist and an obstetrician/paediatrician, came together to change the way we understand and approach mental health. Shivam Dubey and Salel Gupta share their unique journey, discussing the urgent need for preventive mental health care and the ground breaking MindSync curriculum they've developed for schools. They highlight the lack of emotional education in traditional healthcare and school systems, and reveal how their program brings evidence-based life skills, resilience training, and social-emotional learning directly to children and adults in India, Dubai, and the US.   The discussion also takes a deep dive into the relationship between love, quantum theory, and mental well-being. Drawing from both Western science and Eastern philosophy, Dr Dubey and Dr Gupta examine how consciousness and compassion can reshape the way we think about health, learning, and adversity. If you're curious about holistic approaches to wellness, or how culture, spirituality, and modern medicine intersect in the quest for better mental health, this episode brings fresh insight and practical ideas for individuals, educators, and communities. Takeaways The collaboration between psychiatry and obstetrics can enhance preventive mental health. Love has a profound impact on mental health and healing. Quantum theory offers a new perspective on spirituality and consciousness. Mental health education is crucial for children and should be formalized in schools. Self-awareness and emotional skills are essential for personal development. Adversity can be a teacher if we reflect on our experiences. Compassion should be prioritized over competition in education. The Mind-Sync curriculum aims to integrate mental health education into schools. Mighty Champions of Mental Health empowers adults to support their communities. Selfless love is a key component of emotional well-being. titles Exploring the Intersection of Love and Quantum Theory The Healing Power of Love in Mental Health Sound Bites "Love is the healing factor." "Selfless love is the ultimate goal." "Adversity is meant for you to learn." Chapters 00:00 Introduction to Dr. Dube and Dr. Gupta 02:34 The Journey of Dr. Dube and Dr. Gupta 07:29 Exploring Love and Quantum Theory 13:44 The Intersection of Science and Spirituality 26:21 The Need for Mental Health Education 31:55 Exploring Spirituality and Quantum Effects 37:21 Introducing the Mind-Sync Curriculum 43:41 Mental Health Education for All Ages 47:52 Mighty Champions of Mental Health 52:14 Self-Care and Emotional Well-Being 53:55 Outro 

Atrial Fibrillation is the most commonly diagnosed cardiac arrhythmia. In this video we cover what is atrial fibrillation, the signs and symptoms, causes of atrial fibrillation and the complications of atrial fibrillation. We also look at how atrial fibrillation is diagnosed, and treated (with rate vs rhythm control). PDFs available here: https://rhesusmedicine.com/pages/cardiologyFor more medicine videos consider subscribing (if you found any of the info useful!): https://www.youtube.com/channel/UCRks8wB6vgz0E7buP0L_5RQ?sub_confirmation=1Buy Us A Coffee!: https://www.buymeacoffee.com/rhesusmedicineTimestamps:0:00 What is Atrial Fibrillation?0:12 Atrial Fibrillation Pathophysiology1:14 Atrial Fibrillation Causes2:39 Atrial Fibrillation Signs and Symptoms3:30 Atrial Fibrillation Complications4:35 Atrial Fibrillation Diagnosis5:28 Atrial Fibrillation Management (Rate vs Rhythm Control) LINK TO SOCIAL MEDIA: https://www.instagram.com/rhesusmedicine/ReferencesDing, W.Y., Gupta, D. & Lip, G.Y.H., 2020. Atrial fibrillation and the prothrombotic state: revisiting Virchow's triad in 2020. Heart, 106(19), pp.1463–1468. [online] Available at: https://pubmed.ncbi.nlm.nih.gov/32675218/. PubMed+1National Center for Biotechnology Information (NCBI), 2016. Symptoms in atrial fibrillation: a contemporary review and future directions. PMCID: PMC5089512. [online] Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5089512/. PMCNational Center for Biotechnology Information (NCBI), 2020. Etiology, pathology, and classification of atrial fibrillation. PMCID: PMC7250635. [online] Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250635/. PMCWikipedia, 2025. Atrial fibrillation: Causes. [online] Available at: https://en.wikipedia.org/wiki/Atrial_fibrillation#Causes. WikipediaNICE Clinical Knowledge Summaries (CKS), 2025. Atrial fibrillation – prevalence. [online] Available at: https://cks.nice.org.uk/topics/atrial-fibrillation/background-information/prevalence/. Clinical Knowledge SummaryDisclaimer: Please remember this podcast and all content from Rhesus Medicine is for educational and entertainment purposes only and is not a guide to diagnose or to treat any form of condition. The content is not to be used to guide clinical practice and is not medical advice. Please consult a healthcare professional for medical advice.

What if Forrest Gump taught a six-year-old how to never worry about money again? In this episode, Jerremy Newsome shares how watching Forrest Gump at age six sparked a question that changed everything: "What does it mean to not have to worry about money?" That question led him to pick blackberries door-to-door, earning $1,500 that his dad matched to buy $3,000 worth of Apple stock in 1995. While those shares would be worth $39 million today, Jerremy sold them in 2000 for $12,000. That early win, and the lesson from selling too soon, ignited a 20-year journey mastering liquid markets. Now Jerremy helps people understand stocks, options, crypto, and other "liquid markets" using what he calls "second grade math" to achieve financial freedom. He shares the story of Jordan, a police officer making $80,000 a year who recently made more in one month trading than his entire monthly salary. But Jerremy's impact goes beyond teaching trading. When he stood up at a Vail event and matched $40,000 in donations for blind and special needs children learning to ski, he didn't just change those kids' lives. He turned a skeptic named Preston Brown into a lifelong friend and business ally. Jerremy reveals how meeting his wife at a Tony Robbins event, connecting with business partner Brittany Turner through Instagram, and operating from abundance instead of scarcity has created a life where impact matters more than income.   [00:04:00] The Forrest Gump Moment That Changed Everything At age six, watching Forrest Gump with his dad and brother when Lieutenant Dan "invested in some kind of fruit company" Growing up poor, hearing someone didn't have to worry about money was a huge paradigm shift Asked his dad what investing meant, learned about Apple as a computer company Dad gave every excuse: "I don't have time, I'm not smart enough, I don't have enough money" [00:05:20] Picking Blackberries to Buy Apple Stock Dad said "If you bring me some money, I'll match it dollar for dollar" Jerremy's favorite quote: "It's not your resources, it's your resourcefulness" Picked blackberries, sold them door-to-door for a dollar a bag in summer 1995 Made $1,500, dad borrowed from uncle to match, bought $3,000 of Apple at exact bottom [00:06:00] The $39 Million Lesson Those shares today worth about $39 million Sold them in 2000 for $12,000 when family moved from Georgia to Florida Dad called it "the best investment, the best trade I'd ever make my whole life" Got $12,000 at age 12 and has been studying markets "like a heathen" ever since [00:07:00] From History Teacher Dream to Teaching Financial Freedom Wanted to be history teacher since fourth grade, teacher said "You don't get paid any money" Has blend of entrepreneur spirit and teacher spirit Loves learning unique things and teaching them simply because that's how he learns Teaches "liquid markets": stocks, options, crypto, futures, bonds, gold, silver, commodities [00:08:00] Making Complex Things Simple What motivates him: helping people understand complex subjects and explaining them easily When someone learns something and it clicks, that energizes him more than anything Teaches "second grade math to how to become financially free as quick as possible" If you have access to internet, you have access to income once you have knowledge and tools [00:09:20] Jordan the Police Officer's Transformation Started working with Jordan 7-8 months ago, police officer in Northern California making $80,000/year Jordan said police officers are massively undertrained, don't have equipment/knowledge for wide array of situations Last month Jordan made more trading than his monthly salary Made $12,000 net on $60,000 account (20% return in one month) [00:11:20] From Scarcity to Abundance Jordan paying off debts, taking wife and kids to Disneyland Using money to feel abundant, taste prosperity, be in place of creation versus fear Most people find themselves in scarcity when it comes to money The opportunity to create income exists every single day in the stock market [00:12:20] Giving People Choices and Freedom Jordan now realizes he has choices and options For entrepreneurs doing $500K-$3M, you're in the swamp: making enough to do well but not enough to be free Mindset shift from "I have to work to make money" to "I get to create to attract more value" Making (grinding energy) versus attracting/receiving/creating (different energy) [00:15:40] Two People Who Changed Everything His wife: Met at Tony Robbins UPW event November 4, 2012 in Orlando Brittany Turner: Reached out via Instagram in February 2020 through mutual connection Both have helped him heal, expand, and step into greatness [00:16:00] Meeting His Wife at Tony Robbins Boss said "you really should go to this Tony Robbins event called UPW" Met his wife at Unleash the Power Within in Orlando Took 12 years to figure it out, got married about five years ago Have three boys together, she's helped him expand and step into greatness [00:17:00] The Brittany Turner Partnership Needed real estate specialist for his Money Grows on Trees conference Sent Brittany Turner video via Instagram DM in February 2020 In coming-up-on-six-year relationship: organizations built, purpose stepped into, islands, investments, opportunities Alignment with someone who brings joy, understanding, and awareness of more into your life [00:18:40] The Web of Million Dollar Connections Brittany introduced him to Ané Gupta (relationship specialist) Ané introduced him to Chuck Hogan who ran Your Best Life mastermind Chuck's mastermind had three main members: Chuck, Dean, and Preston Brown Got asked to speak at event in Vail, Colorado in February 2022 [00:19:40] The $80,000 Donation That Changed a Relationship Organization helping blind and special needs kids learn to ski said "$5,000 would change our whole life" Preston Brown admittedly didn't like Jerremy before they met Jerremy stood up and said "I will match every donation given today" Room raised over $40,000, Jerremy matched $40,000 for $80,000 total to Little Champions [00:21:00] From Skeptic to Lifelong Friend Preston came up afterwards, gave hug: "You are my guy, that reminded me of Christ" "Between me and you, we'll be friends for life" Preston has given so much business, referrals, opportunities since Coming to Vegas this weekend with 40 entrepreneurs for "radical business" [00:23:00] When Making More Money Ceases to Inspire Kevin: Once family needs are met, making more money ceased to inspire him Having conversations with entrepreneurs, making introductions that lead to big deals, that's what inspires It's not the revenue, it's the impact Les Brown taught Jerremy: "Your income is directly tied to your impact" [00:25:40] Connecting with Jerremy Name spelled J-E-R-R-E-M-Y (stands for Jerry + Me, his dad's name was Jerry) Newsome: N-E-W-S-O-M-E.com All social media platforms, look for blue verified check mark Broke to Woke podcast with Brittany Turner (six seasons, 24 episodes, season seven coming) [00:27:00] Ask For More Awareness of what's possible comes by asking for more It's okay to want more so you can offer more, provide more, give more God is the God of infinite, receiving more doesn't take away from anyone else "Those who knock, door is opened" - ask for more and change your awareness   KEY QUOTES "It's not your resources, it's your resourcefulness. That's probably what entrepreneurship is." - Jerremy Newsome "If you have access to the internet, you have access to income once you have the knowledge and the skills and the tools." - Jerremy Newsome "The secret to living is giving, and one of the best things to give is the gift of a relationship." - Jerremy Newsome "Your income is directly tied to your impact. You wanna make more, figure out a way to impact more." - Les Brown (quoted by Jerremy) CONNECT WITH JERREMY NEWSOME 

In this episode of Tranche Talk, we welcome back Bank of America's Pratik Gupta who talks with 9fin's Tanvi Gupta on the defining moments of 2025 and what the new year will bring for CLOs.They discuss CLO being the best asset class to sell in a rate cutting cycle and the opportunities to rotate into RMBS AAAs, separating facts from fiction for private credit CLO fears and the demand landscape between Japanese banks, US banks and ETFs.They also delve into CLO equity performance, opportunities for CLO managers in portfolio trading and how CLO managers should differentiate themselves when they're all chasing the same conservative assets.

Jason Kander and Ravi Gupta break down the Republican revolt that forced a vote on extending Obamacare subsidies, as four GOP lawmakers joined Democrats on a discharge petition to prevent premiums from doubling for millions of Americans. They analyze the political fallout for House Republicans in swing districts, Speaker Mike Johnson's failed negotiations, and the looming deadline that could leave 22 million people facing higher health care costs. Kander and Gupta also dive into a wave of national turmoil, from mass shootings and rising antisemitism among young Americans to chaos and incompetence inside Trump's law enforcement leadership and explosive reactions to Trump's own rhetoric. Plus, they discuss new reporting on Susie Wiles, deepening MAGA infighting, growing backlash to AI and Big Tech, and fresh polling showing cracks in Trump's base. This and more on the podcast that helps you, the majority of Americans who believe in progress, convince your conservative friends and family to join us—this is Majority 54! Aura Frames: Exclusive $35 off Carver Mat at https://on.auraframes.com/MAJORITY54 Promo Code MAJORITY54 Dupe: For a limited time, the first 10,000 people who go to https://Dupe.com/majority will instantly get 500 Dupe Points IndaCloud: If you're 21 or older, get 25% OFF your first order + free shipping @IndaCloud with code MAJORITY at https://inda.shop/MAJORITY! #indacloudpod Subscribe to Ravi's Substack: https://realravigupta.substack.com/ For more information visit: https://www.ravimgupta.com/analog Majority 54 on Twitter: https://twitter.com/majority54 Jason on Twitter: https://twitter.com/JasonKander Jason on Instagram: https://www.instagram.com/jasonkander/ Ravi on Twitter: https://twitter.com/RaviMGupta Ravi on Instagram: https://www.instagram.com/ravimgupta Ravi on Youtube: https://www.youtube.com/@LostDebate Remember to subscribe to ALL the MeidasTouch Network Podcasts: MeidasTouch: https://www.meidastouch.com/tag/meidastouch-podcast Legal AF: https://www.meidastouch.com/tag/legal-af MissTrial: https://meidasnews.com/tag/miss-trial The PoliticsGirl Podcast: https://www.meidastouch.com/tag/the-politicsgirl-podcast The Influence Continuum: https://www.meidastouch.com/tag/the-influence-continuum-with-dr-steven-hassan Learn more about your ad choices. Visit megaphone.fm/adchoices

Description:Today's guest is someone who instantly made an impression on Jen when they met at a recent Hello Sunshine event in LosAngeles, when she moderated a Shine Away panel with Jen and beloved 9010 star and recent For the Love guest, Jennie Garth. Within five minutes Jen thought, “Okay… she's one of us.” Warm, sharp, steady — Kanika Chadda-Gupta has this grounding presence that makes a whole room exhale. An award-winning former CNN journalist and producer, Kanika built a thriving career in television news before motherhood rerouted her life in the most profound way. Born in India and raised in the U.S., her story is braided with themes so many of us know intimately: immigration and bicultural identity, the expectations women inherit, the invisible labor we carry, and the endless negotiation between ambition, caregiving, and our own becoming. Today, Kanika is the creator and host of the beloved Total Mom Sense podcast, where she distills her lived experience — raising children while caring for aging parents, navigating mental and emotional load, reinventing purpose in midlife — into practical wisdom for women who are doing it all and feeling all of it. In this conversation, we talk about what happens when life asks us to reevaluate our pace, our priorities, and the stories we've been handed about success. We discuss staying rooted inside seasons of huge responsibility, finding yourself in the middle of caregiving, and reclaiming a sense of agency and identity in motherhood and beyond. If you've ever felt stretched thin between generations, pulled in every direction, or unsure how to follow your own calling while caring for everyone else — Kanika's clarity and compassion will feel like a deep breath. This one's for all of us standing at the intersection of who we were, who we are, and who we're still becoming. Thought-provoking Quotes: "I like getting the gold star from all of my teachers. I did all the AP classes. I hung out with my teachers at lunchtime. We had open lunch, and it was like you could go to McDonald's, or you could go across the street to the pizza place. But I would go sit with Ms. Townsend, my biology teacher, and just kick it.” – Kanika Chadda-Gupta "It may be, the only headlights that you see heading to the eye of the storm are the first responders and the reporters. And I thought, I want to be in the eye of the storm. I belong here. I need to be here. I need to prove myself. And so then I stayed.” – Kanika Chadda-Gupta "I was most surprised by how your kids will make you face your childhood trauma head on. My dad and I get along great now, but when we were younger, he would say things that really just shot my self-esteem. And those are the first things that come up when my kids do something wrong and I'm like, wow, I gotta reframe." – Kanika Chadda-Gupta Resources Mentioned in This Episode: Hello Sunshine Shine Away Conference 2025 – https://shineaway.hello-sunshine.com/event/eddb3575-ec80-4812-a371-354c900d7cbf/summary Jim Gaffigan, comedian – https://www.jimgaffigan.com/ Mom Brain with Hilaria Baldwin and Daphne Oz - https://podcasts.apple.com/us/podcast/mom-brain/id1438292826 Guest's Links: Website - https://kanikachaddagupta.com/ Instagram - https://www.instagram.com/kanikachaddagupta/ Twitter - https://x.com/KanikaChadda Facebook - https://www.facebook.com/kanikachaddagupta/ Youtube - https://www.youtube.com/channel/UCgkOq_AmLsvu6YJsKglQvSw TikTok - https://www.tiktok.com/@kanikachaddagupta?lang=en Pinterest - https://www.pinterest.com/kanikachaddagupta/ Podcast - https://kanikachaddagupta.com/podcast/ Connect with Jen!Jen's Website - https://jenhatmaker.com/ Jen's Instagram - https://instagram.com/jenhatmakerJen's Twitter - https://twitter.com/jenHatmaker/ Jen's Facebook - https://facebook.com/jenhatmakerJen's YouTube - https://www.youtube.com/user/JenHatmaker The For the Love Podcast is presented by Audacy.  To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

JCO PO author Dr. Shilpa Gupta at Cleveland Clinic Children's Hospital shares insights into her article, "Fibroblast Growth Factor Receptor 3 (FGFR3) Alteration Status and Outcomes on Immune Checkpoint Inhibitors (ICPI) in Patients with Metastatic Urothelial Carcinoma". Host Dr. Rafeh Naqash and Dr. Gupta discuss how FGFR3 combined with TMB emerged as a biomarker that may be predictive for response to ICPI in mUC. TRANSCRIPT Dr. Rafeh Naqash: Hello and welcome to JCO Precision Oncology Conversations, where we bring you engaging conversations with authors of clinically relevant and highly significant JCO PO articles. I'm your host, Dr. Rafeh Naqash, podcast editor for JCO Precision Oncology and Associate Professor at the OU Health Stephenson Cancer Center. Today I am excited to be joined by Dr. Shilpa Gupta, Director of Genitourinary Medical Oncology at the Cancer Institute and co-leader of the GU Oncology Program at the Cleveland Clinic, and also lead author of the JCO PO article titled "Fibroblast Growth Factor Receptor 3 Alteration Status and Outcomes on Immune Checkpoint Inhibitors in Patients With Metastatic Urothelial Carcinoma." At the time of this recording, our guest's disclosures will be linked in the transcript. Shilpa, welcome again to the podcast. Thank you for joining us today. Dr. Shilpa Gupta: Thank you, Rafeh. Honor to be here with you again. Dr. Rafeh Naqash: It is nice to connect with you again after two years, approximately. I think we were in our infancy of our JCO PO podcast when we had you first time, and it has been an interesting journey since then. Dr. Shilpa Gupta: Absolutely. Dr. Rafeh Naqash: Well, excited to talk to you about this article that you published. Wanted to first understand what is the genomic landscape of urothelial cancer in general, and why should we be interested in FGFR3 alterations specifically? Dr. Shilpa Gupta: Bladder cancer or urothelial cancer is a very heterogeneous cancer. And while we find there is a lot of mutations can be there, you know, like BRCA1, 2, in HER2, in FGFR, we never really understood what is driving the cancer. Like a lot of old studies with targeted therapies did not really work. For example, we think VEGF can be upregulated, but VEGF inhibitors have not really shown definite promise so far. Now, FGFR3 receptor is the only therapeutic target so far that has an FDA approved therapy for treating metastatic urothelial cancer patients, and erdafitinib was approved in 2019 for patients whose tumors overexpressed FGFR3 mutations, alterations, or fusions. And in the landscape of bladder cancer, it is important because in patients with non-muscle invasive bladder cancer, about 70 to 80% patients can have this FGFR3. But as patients become metastatic, the alterations are seen in, you know, only about 10% of patients. So the clinical trials that got the erdafitinib approved actually used archival tumor from local cancer. So when in the real world, we don't see a lot of patients if we are trying to do metastatic lesion biopsies. And why it is important to know this is because that is the only targeted therapy available for our patients right now. Dr. Rafeh Naqash: Thank you for giving us that overview. Now, on the clinical side, there is obviously some interesting data for FGFR3 on the mutation side and the fusion side. In your clinical practice, do you tend to approach these patients differently when you have a mutation versus when you have a fusion? Dr. Shilpa Gupta: We can use the treatment regardless of that. Dr. Rafeh Naqash: I recently remember I had a patient with lung cancer, squamous lung cancer, who also had a synchronous bladder mass. And the first thought from multiple colleagues was that this is metastatic lung. And interestingly, the liquid biopsy ended up showing an FGFR3-TACC fusion, which we generally don't see in squamous lung cancers. And then eventually, I was able to convince our GU colleagues, urologists, to get a biopsy. They did a transurethral resection of this tumor, ended up being primary urothelial and synchronous lung, which again, going back to the FGFR3 story, I saw in your paper there is a mention of FGFR3-TACC fusions. Anything interesting that you find with these fusions as far as biology or tumor behavior is concerned? Dr. Shilpa Gupta: We found in our paper of all the patients that were sequenced that 20% had the pathognomonic FGFR3 alteration, and the most common were the S249C, and the FGFR3-TACC3 fusion was in 45 patients. And basically I will say that we didn't want to generate too much as to fusion or the differences in that. The key aspect of this paper was that historically there were these anecdotal reports saying that patients who have FGFR alterations or mutations, they may not respond well to checkpoint inhibitors because they have the luminal subtype. And these were backed by some preclinical data and small anecdotal reports. But since then, we have seen that, and that's why a lot of people would say that if somebody's tumor has FGFR3, don't give them immunotherapy, give them erdafitinib first, right? So then we had this Phase 3 trial called the THOR trial, which actually showed that giving erdafitinib before pembrolizumab was not better. That debunked that myth, and we are actually reiterating that because in our work we found that patients who had FGFR3 alterations or fusions, and if they also have TMB-high, they actually respond very well to single agent immunotherapy. And that is, I think, very important because it tells us that we are not really seeing that so-called potential of resistance to immunotherapy in these patients. So to answer your question, yeah, we did see those differences, but I wouldn't say that any one marker is more prominent. Dr. Rafeh Naqash: The analogy is kind of similar to what we see in lung cancer with these mutations called STK11/KEAP1, which are also present in some other tumors. And one of the questions that I don't think has been answered is when you have in lung cancer, if you extrapolate this, where doublet or single agent immunotherapy doesn't do as well in tumors that are STK11 mutated. But then if you have a high TMB, question is does that TMB supersede or trump the actual mutation? Could that be one reason why you see the TMB-high but FGFR3 altered tumors in your dataset responding or having better outcomes to immunotherapy where potentially there is just more neoantigens and that results in a more durable or perhaps better response to checkpoint therapy? Dr. Shilpa Gupta: It could be. But you know, the patients who have FGFR alterations are not that many, right? So we have already seen that just patients with TMB-high respond very well to immunotherapy. Our last podcast was actually on that, regardless of PD-L1 that was a better predictor of response to immunotherapy. So I think it's not clear if this is adding more chances of response or not, because either way they would respond. But what we didn't see, which was good, that if they had FGFR3, it's not really downplaying the fact that they have TMB-high and that patients are not responding to immunotherapy. So we saw that regardless, and that was very reassuring. Dr. Rafeh Naqash: So if tomorrow in your clinic you had an individual with an FGFR3 alteration but TMB-high, I guess one could be comfortable just going ahead with immunotherapy, which is what the THOR trial as you mentioned. Dr. Shilpa Gupta: Yes, absolutely. And you know, when you look at the toxicity profiles of pembrolizumab and erdafitinib, really patients really struggle with using the FGFR3 inhibitors. And of course, if they have to use it, we have to, and we reserve it for patients. But it's not an easy drug to tolerate. Currently the landscape is such that, you know, frontline therapy has now evolved with an ADC and immunotherapy combinations. So really if patients progress and have FGFR3 alterations, we are using erdafitinib. But let's say if there were a situation where a patient has had chemotherapy, no immunotherapy, and they have FGFR3 upregulation and TMB-high, yes, I would be comfortable with using only pembrolizumab. And that really ties well together what we saw in the THOR trial as well. Dr. Rafeh Naqash: Going to the clinical applications, you mentioned a little bit of this in the manuscript, is combination therapies. You alluded to it a second back. Everything tends to get combined with checkpoint therapy these days, as you've seen with the frontline urothelial, pembrolizumab with an ADC. What is the landscape like as far as some of these FGFR alterations are concerned? Is it reasonable to combine some of those drugs with immune checkpoint therapy? And what are some of the toxicity patterns that you've potentially seen in your experience? Dr. Shilpa Gupta: So there was indeed a trial called the NORSE trial. It was a randomized trial but not a comparative cohort, where they looked at FGFR altered patients. And when they combined erdafitinib plus cetrelimab, that did numerically the response rates were much higher than those who got just erdafitinib. So yeah, the combination is definitely doable. There is no overlapping toxicities. But unfortunately that combination has not really moved forward to a Phase 3 trial because it's so challenging to enroll patients with such kind of rare mutations on large trials, especially to do registration trials. And since then the frontline therapy has evolved to enfortumab vedotin and pembrolizumab. I know there is an early phase trial looking at a next generation FGFR inhibitor. There is a triplet combination looking in Phase 1 setting with a next generation FGFR inhibitor with EV-pembro. However, it's not a randomized trial. So you know, I worry about such kinds of combinations where we don't have a path for registration. And in the four patients that have been treated, four or five patients in the early phase as a part of basket trial, the toxicities were a lot, you know, when you combine the EV-pembro and an FGFR3 inhibitor, we see more and more toxicity. So the big question is do we really need the "kitchen sink" approach when we have a very good doublet, or unless the bar is so high with the doublet, like what are we trying to add at the expense of patient toxicity and quality of life is the big question in my mind. Dr. Rafeh Naqash: Going back to your manuscript specifically, there could be a composite biomarker. You point out like FGFR in addition to FGFR TMB ends up being predictive prognostic there. So that could potentially be used as an approach to stratify patients as far as treatment, whether it's a single agent versus combination. Maybe the TMB-low/FGFR3 mutated require a combination, but the TMB-high/FGFR mutated don't require a combination, right? Dr. Shilpa Gupta: No, that's a great point, yeah. Dr. Rafeh Naqash: But again, very interesting, intriguing concepts that you've alluded to and described in this manuscript. Now, a quick take on how things have changed in the bladder cancer space in the last two years. We did a podcast with you regarding some biomarkers as you mentioned two years back. So I really would like to spend the next minute to two to understand how have things changed in the bladder cancer space? What are some of the exciting things that were not there two years back that are in practice now? And how do you anticipate the next two years to be like? Maybe we'll have another podcast with you in another two years when the space will have changed even more. Dr. Shilpa Gupta: Certainly a lot has happened in the two years, you know. EV-pembro became the universal frontline standard, right? We have really moved away from cisplatin eligibility in metastatic setting because anybody would benefit from EV-pembro regardless of whether they are candidates for cisplatin or not, which historically was relevant. And just two days ago, we saw that EV-pembro has now been approved for localized bladder cancer for patients who are cisplatin ineligible or refusing. So, you know, this very effective regimen moving into earlier setting, we now have to really think of good treatment options in the metastatic setting, right? So I think that's where a lot of these novel combinations may come up. And what else we've seen is in a tumor agnostic trial called the DESTINY-PanTumor trial, patients who had HER2 3+ on immunohistochemistry, we saw the drug approval for T-DXd, and I think that has kind of reinvigorated the interest in HER2 in bladder cancer, because in the past targeting HER2 really didn't work. And we still don't know if HER2 is a driver or not. And at ESMO this year, we saw an excellent study coming out of China with DV which is targeting HER2, and toripalimab, which is a Chinese checkpoint inhibitor, showing pretty much similar results to what we saw with EV-pembro. Now, you know, not to do cross-trial comparisons, but that was really an amazing, amazing study. It was in the presidential session. And I think the big question is: does that really tell us that HER2-low patients will not benefit? Because that included 1+, 2+, 3+. So that part we really don't know, and I think we want to study from the EV-302 how the HER2 positive patients did with EV and pembro. So that's an additional option, at least in China, and hopefully if it gets approved here, there is a trial going on with DV and pembro. And lastly, we've seen a very promising biomarker, like ctDNA, for the first time in bladder cancer in the adjuvant setting guiding treatment with adjuvant atezolizumab. So patients who were ctDNA positive derived overall survival and recurrence-free survival benefit. So that could help us select moving forward with more studies. We can spare unnecessary checkpoint inhibitors in patients who are not going to benefit. So I think there is a lot happening in our field, and this will help do more studies because we already have the next generation FGFR inhibitors which don't have the toxicities that erdafitinib comes with. And combining those with these novel ADCs and checkpoint inhibitors, you know, using maybe TMB as a biomarker, because we really need to move away from PD-L1 in bladder cancer. It's shown no utility whatsoever, but TMB has. Dr. Rafeh Naqash: Well, thank you so much, Shilpa, for that tour de force of how things have changed in bladder cancer. There used to be a time when lung and melanoma used to lead this space in terms of the number of approvals, the biomarker development. It looks like bladder cancer is shifting the trend at this stage. So definitely exciting to see all the new changes that are coming up. I'd like to spend another minute and a half on your career. You've obviously been a leader and example for many people in the GU space and beyond. Could you, for the sake of our early career especially, the trainees and other listeners, describe how you focused on things that you're currently leading as a leader, and how you shaped your career trajectory over the last 10 years? Dr. Shilpa Gupta: That's a really important question, Rafeh, and you and I have had these discussions before, you know, being an IMG on visas like you, and being in different places. I think I try to make the most of it, you know, instead of focusing on the setbacks or the negative things. Like tried to grab the opportunities that came along. When I was at Moffitt, got to get involved with the Phase 1 trial of pembrolizumab in different tumor types. And just keeping my options open, you know, getting into the bladder cancer at that time when I wanted to really do only prostate, but it was a good idea for me to keep my options open and got all these opportunities that I made use of. I think an important thing is to, like you said, you know, have a focus. So I am trying to focus more on biomarkers that, you know, we know that 70% patients will respond to EV-pembro, right? But what about the remaining 30%? Like, so I'm really trying to understand what determines hyperprogressors with such effective regimens who we really struggle with in the clinic. They really don't do well with anything we give them after that. So we are doing some work with that and also trying to focus on PROs and kind of patient-reported outcomes. And a special interest that I've now developed and working on it is young-onset bladder cancer. You know, the colorectal cancer world has made a lot of progress and we are really far behind. And bladder cancer has historically been a disease of the elderly, which is not the case anymore. We are seeing patients in their 30s and 40s. So we launched this young-onset bladder cancer initiative at a Bladder Cancer Advocacy Network meeting and now looking at more deep dive and creating a working group around that. But yeah, you know, I would say that my philosophy has been to just take the best out of the situation I'm in, no matter where I am. And it has just helped shape my career where I am, despite everything. Dr. Rafeh Naqash: Well, thank you again. It is always a pleasure to learn from your experiences and things that you have helped lead. Appreciate all your insights, and thank you for publishing with JCO PO. Hopefully we will see more of your biomarker work being published and perhaps bring you for another podcast in a couple of years. Dr. Shilpa Gupta: Yeah, thank you, Rafeh, for the opportunity. And thanks to JCO PO for making these podcasts for our readers. So thanks a lot. Dr. Rafeh Naqash: Thank you for listening to JCO Precision Oncology Conversations. Don't forget to give us a rating or review and be sure to subscribe so you never miss an episode. You can find all ASCO shows at asco.org/podcast. The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. DISCLOSURES Dr. Shilpa Gupta Stock and Other Ownership Interests: Company: BioNTech SE,  Nektar Consulting or Advisory Role: Company: Gilead Sciences, Pfizer, Merck, Foundation Medicine, Bristol-Myers Squibb/Medarex, Natera, Astellas Pharma, AstraZeneca, Novartis, Johnson & Johnson/Janssen Research Funding: Recipient: Your Institution Company: Bristol Myers Squibb Foundation, Merck, Roche/Genentech, EMD Serono, Exelixis, Novartis, Tyra Biosciences, Pfizer, Convergent Therapeutics, Acrivon Therapeutics, Flare Therapeutics, Amgen Travel, Accommodations, Expenses: Company: Pfizer, Astellas Pharma, Merck    

What does it take to build a biotech company without burning billions—or losing your conviction? In this episode of CPO PLAYBOOK, Felicia Shakiba sits down with Dr. Shalabh Gupta, Founder & CEO of Unicycive Therapeutics, a physician-turned-Wall-Street-analyst who built and took a biotech company public in a way few ever do. Dr. Gupta shares how he raised $150M+ in public markets, went public with just one employee, and scaled to FDA submission readiness with only 22 people—all without relying on traditional Silicon Valley venture capital. This conversation unpacks what real CEO discipline looks like in one of the most unforgiving industries in the world—and what leaders in any industry can learn from it. You'll learn: • Why great CEOs start with the problem—not the product • How to scale a capital-intensive business with radical focus • Why FDA alignment is a leadership skill, not a regulatory hurdle • How public-market thinking changes founder decision-making • What investors actually look for in CEO credibility and trust Chapters 00:00 Introduction to Unisysive Therapeutics 04:27 Innovative Approach to Biotech 07:55 Understanding the Biotech Landscape 10:39 Transition from Medicine to Wall Street 14:08 Lessons from Genentech 19:46 Building a Company Alone 22:47 The Importance of Networking 27:00 Engaging with the FDA 30:57 Raising Capital in Biotech 41:58 Navigating Investor Relationships This episode is a masterclass in purpose-driven leadership, capital discipline, and building companies that last. — Subscribe to CPO PLAYBOOK for more conversations at the intersection of leadership, innovation, and capital strategy: https://www.cpoplaybook.com/newsletter Need support scaling leadership or culture? Let's talk: https://www.cpoplaybook.com/contact-us

Visibility is a superpower for leaders—but building it authentically can feel challenging. On this episode, Surbhi Gupta, host of The Visibility Equation and seasoned product leader, sits down with Lexy Franklin, CEO & Founder of Sidebar, to explore how leaders can own their narrative, amplify their impact, and connect with their authentic selves.Lexy shares practical strategies on building visibility, overcoming public speaking anxiety, nurturing relationships, and navigating the leadership journey. Together, they dive into inspiring stories, actionable insights, and the realities behind professional growth at leadership levels

From patents to IPOs to international bridge titles, Vinita Gupta has navigated male-dominated arenas with clarity and courage. In this fireside chat with Nalini Elkins, she shares fresh takes from her new memoir on resilience, inclusion, and building durable success in a volatile world—plus what it takes to keep learning through every pivot. join us to hear her timely playbook for founders, operators and the curious. Vinita Gupta is a Silicon Valley entrepreneur and the first woman of Indian origin to take a company public in the United States. Her memoir, The Woman in Deed: Road to IPO, Bridge Tables, and Beyond, traces a life of invention, leadership, and competitive bridge at the highest levels. She writes on innovation, integrity, and reinvention across the India–U.S. corridor. Nalini Elkins, the CEO and founder of Inside Products, Inc., is a recognized leader in the field of computer performance measurement and analysis. She is also the chief technical officer and co-founder of Outside the Stacks. An accomplished software product designer, developer and strategist, she has founded or co-founded three high-tech start-ups over the course of her career. In 2014, Nalini was awarded the prestigious AA Michelson Award by the Computer Measurement Group (CMG). An International Relations Member-led Forum program. Forums at the Club are organized and run by volunteer programmers who are members of The Commonwealth Club, and they cover a diverse range of topics. Learn more about our Forums. Commonwealth Club World Affairs is a public forum. Any views expressed in our programs are those of the speakers and not of Commonwealth Club World Affairs. Organizer: Frank Price  Learn more about your ad choices. Visit megaphone.fm/adchoices

Taruna Gupta is a Senior Associate at HGA Milwaukee where she works on projects that champion holistic design, equity, and sustainability. She is President of Wisco NOMA and is a board member of Women in Design Milwaukee. Taruna is also Co-Founder and President of Defining Humanity where she leads global initiatives such as 3D-printed schools and housing solutions that redefine architecture's role in addressing equity and access in communities around the world.We talk about: - Lessons Taruna has learned from practicing architecture in India, Italy, France, and the United States. We talk about the ways in which these roles have expanded her cultural fluency and strengthened her adaptability in terms of the design process, construction techniques, labor models, and metric vs imperial systems.- The origin of Defining Humanity and how she has helped to build a volunteer network of professionals that collaborate to significantly impact underserved communities worldwide through architectural interventions.- 3D printing schools in Madagascar and the importance of listening to and engaging communities, ensuring people feel truly heard.- Taruna's advice for authentic networking, leaning into your passions during conversation, and using the “buddy system” to make professional events less intimidating.>>>Connect with Taruna:LinkedIn: https://www.linkedin.com/in/tarunagupta/Defining Humanity Website: https://www.defininghumanity.org/Defining Humanity Instagram: @defininghumanity>>>Connect with Architectette:- Website: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ www.architectette.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ (Learn more)- Instagram:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ @architectette⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ (See more)- Newsletter:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ www.architectette.com/newsletter⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ (Behind the Scenes Content)- LinkedIn:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ The Architectette Podcast⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Page and/or⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Caitlin Brady⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠>>> Support Architectette:- Leave us a rating and review!>>>Music by⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ AlexGrohl⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ from ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Pixabay⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠.

Dr. Sunil Gupta addressed several common diabetes-related myths—especially those that spread during festivals—such as the false belief that diabetes spreads through touch, that bitter gourd juice is a cure, or that eating sweets directly causes diabetes. He clarified that such misconceptions can misguide people and delay proper care. Dr. Gupta explained that tingling or numbness in the hands and feet is not always due to high sugar levels; it can also be caused by nerve pressure, sitting posture, or Vitamin B12 deficiency. In Type 2 diabetes, medicines may reduce with disciplined lifestyle changes, but complete cure is rare. Diabetes may get “reversed” in specific situations such as gestational diabetes after delivery, stress-induced diabetes, or after bariatric surgery. He also highlighted that children's late-night gaming habits harm mental health and sometimes require psychological guidance. Dr. Gupta discussed the stages of Diabetic Retinopathy, noting that retinal damage cannot be reversed, though progression can be slowed with timely treatment. Conditions like Vitamin D3/B12 deficiency, infections, high BP, or glaucoma can also affect vision—so both diabetes and eye specialists should be consulted. Dr. Gupta emphasized that diabetes is a lifestyle condition and individuals should not be labeled as “patients.” Expert- Dr Sunil Gupta   Anchor- Mrs. Shraddha Bharadwaj     Podcast: 11/10/2019 Recorded at: Akashwani Nagpur 

Jason Kander and Ravi Gupta break down Trump's chaotic attempt to rebrand the economy as he mocks “affordability,” confuses inflation with deflation, and delivers a meandering Pennsylvania rally full of distortions. They examine how Americans view Trump's economic record compared to the end of the Biden presidency and why his messaging isn't matching voters' lived experiences. Kander and Gupta also dig into Trump's $12 billion farm bailout sparked by his own tariffs, and the criticism that foreign competitors—not American farmers—benefited most. They explore Trump's push for a sweeping national AI rule to override state protections, as well as his surprising reversal on advanced chip exports to China. Plus, they look at Miami's first Democratic mayor in decades, the GOP's internal fight over Obamacare subsidies, and escalating MAGA infighting heading into 2026. This and more on the podcast that helps you, the majority of Americans who believe in progress, convince your conservative friends and family to join us—this is Majority 54! Hims: Thanks to HIMS! Start your free online visit today at https://hims.com/majority for your personalized ED treatment options Aura Frames: Exclusive $35 off Carver Mat at https://on.auraframes.com/MAJORITY54 Promo Code MAJORITY54 Shopify: Shopify: Sign up for your one-dollar-per-month trial and start selling today at https://SHOPIFY.com/majority Subscribe to Ravi's Substack: https://realravigupta.substack.com/ For more information visit: https://www.ravimgupta.com/analog Shout out to https://immigrantslist.org where people can donate to help get real immigration facts out! Majority 54 on Twitter: https://twitter.com/majority54 Jason on Twitter: https://twitter.com/JasonKander Jason on Instagram: https://www.instagram.com/jasonkander/ Ravi on Twitter: https://twitter.com/RaviMGupta Ravi on Instagram: https://www.instagram.com/ravimgupta Ravi on Youtube: https://www.youtube.com/@LostDebate Remember to subscribe to ALL the MeidasTouch Network Podcasts: MeidasTouch: https://www.meidastouch.com/tag/meidastouch-podcast Legal AF: https://www.meidastouch.com/tag/legal-af MissTrial: https://meidasnews.com/tag/miss-trial The PoliticsGirl Podcast: https://www.meidastouch.com/tag/the-politicsgirl-podcast The Influence Continuum: https://www.meidastouch.com/tag/the-influence-continuum-with-dr-steven-hassan Mea Culpa with Michael Cohen: https://www.meidastouch.com/tag/mea-culpa-with-michael-cohen The Weekend Show: https://www.meidastouch.com/tag/the-weekend-show Burn the Boats: https://www.meidastouch.com/tag/burn-the-boats Majority 54: https://www.meidastouch.com/tag/majority-54 Political Beatdown: https://www.meidastouch.com/tag/political-beatdown On Democracy with FP Wellman: https://www.meidastouch.com/tag/on-democracy-with-fpwellman Uncovered: https://www.meidastouch.com/tag/maga-uncovered Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode, Dr. Zanotti discusses the role of Procalcitonin in the ICU. He is joined by Dr. Simran Gupta, an infectious disease specialist at Brigham & Women's Hospital in Boston. Dr. Gupta has additional training in Clinical Research, Transplant, and Infectious Disease. She recently published an article on reassessing the role of Procalcitonin in critically ill patients with sepsis. Additional resources: Reassessing Procalcitonin-Guided Antibiotic Therapy in Critically Ill Patients with Sepsis: Lessons from the ADAPT-Sepsis Trial. S. Gupta, et al. Clinical Infectious Disease 2025: https://pubmed.ncbi.nlm.nih.gov/40579227/ Biomarker-Guided Antibiotic Duration for Hospitalized Patients With Suspected Sepsis: The ADAPT-Sepsis Randomized Clinical Trial. JAMA 2025: https://pubmed.ncbi.nlm.nih.gov/39652885/ Procalcitonin-guided antibiotic therapy may shorten the length of treatment and may improve survival- a systematic review and meta-analysis. M Papp, et al. Crit Care 2023: https://pubmed.ncbi.nlm.nih.gov/37833778/ Books and entertainment mentioned in this episode: Shantaram: A Novel. By Gregory David Roberts: https://bit.ly/4ovVHKX SHANTARAM – Apple TV series: https://tv.apple.com/us/show/shantaram/umc.cmc.atxsrive40xli3zh3uxjimut

Send us a textOn this replay of Making Data Simple, Manav Gupta, VP and CTO of IBM Canada, jumps straight into the world of large language models and what they really mean for businesses trying to scale AI. From how today's models are built and tuned, to where the next generation is headed, Manav translates complex AI concepts into practical guidance for leaders, practitioners, and anyone trying to cut through the hype.The discussion spans everything from model architectures and IBM's Granite family, to how to pick the right model for your use case, balance innovation with governance, and build the skills needed to stay relevant in an AI-first world. If you want a clear, no-nonsense guide to “all things AI models” from someone advising enterprise clients every day, this replay is for you.​02:04 Jumping Right into AI! 02:59 Meet Manav Gupta 08:17 Let's Talk All Things Models 27:20 How to Choose the Right Models 31:48 Where are the Models Going??? 46:01 How to Learn AILinkedIn: https://www.linkedin.com/in/mgupta76/ IBM Granite Models: https://www.ibm.com/graniteWant to be featured as a guest on Making Data Simple? Reach out to almartintalksdata@gmail.com and share why you should be next.​Hashtags#makingdatasimplepodcast #MakingDataSimple #AI #LargeLanguageModels #AIModels #ArtificialIntelligence #IBMCanada #ManavGupta #AIInnovation #TechLeadership #TechPodcast #IBMGranite #LearnAIRelatedWant to be featured as a guest on Making Data Simple? Reach out to us at almartintalksdata@gmail.com and tell us why you should be next. The Making Data Simple Podcast is hosted by Al Martin, WW VP Technical Sales, IBM, where we explore trending technologies, business innovation, and leadership ... while keeping it simple & fun.

Send us a textOn this replay of Making Data Simple, Manav Gupta, VP and CTO of IBM Canada, jumps straight into the world of large language models and what they really mean for businesses trying to scale AI. From how today's models are built and tuned, to where the next generation is headed, Manav translates complex AI concepts into practical guidance for leaders, practitioners, and anyone trying to cut through the hype.The discussion spans everything from model architectures and IBM's Granite family, to how to pick the right model for your use case, balance innovation with governance, and build the skills needed to stay relevant in an AI-first world. If you want a clear, no-nonsense guide to “all things AI models” from someone advising enterprise clients every day, this replay is for you.​02:04 Jumping Right into AI! 02:59 Meet Manav Gupta 08:17 Let's Talk All Things Models 27:20 How to Choose the Right Models 31:48 Where are the Models Going??? 46:01 How to Learn AILinkedIn: https://www.linkedin.com/in/mgupta76/ IBM Granite Models: https://www.ibm.com/graniteWant to be featured as a guest on Making Data Simple? Reach out to almartintalksdata@gmail.com and share why you should be next.​Hashtags#makingdatasimplepodcast #MakingDataSimple #AI #LargeLanguageModels #AIModels #ArtificialIntelligence #IBMCanada #ManavGupta #AIInnovation #TechLeadership #TechPodcast #IBMGranite #LearnAIRelatedWant to be featured as a guest on Making Data Simple? Reach out to us at almartintalksdata@gmail.com and tell us why you should be next. The Making Data Simple Podcast is hosted by Al Martin, WW VP Technical Sales, IBM, where we explore trending technologies, business innovation, and leadership ... while keeping it simple & fun.

Dr. Arun Kumar Gupta is a leading Nepali rheumatologist, serving as President of the Nepal Rheumatology Association. He heads the Rheumatology Department at Norvic International Hospital and founded the Rheumatology Arthritis Center (RAC). He is recognized for his expertise in autoimmune disorders and his contributions to public medical education.

Dr. Shivani Gupta welcomes board-certified interventional radiologist Dr. Shivank Bhatia, founder of Florida Prostate Centers and Florida Fibroid Centers, to discuss groundbreaking minimally invasive alternatives to common surgeries. Dr. Bhatia, internationally recognized for pioneering embolization therapies, shares his expertise on preserving organs while effectively treating benign conditions. Dr. Gupta opens up about her personal journey battling a 10-centimeter fibroid and almost undergoing unnecessary hysterectomy before discovering embolization. Together, they reveal shocking statistics: 25 million American women have fibroids with 600,000 hysterectomies performed annually (half for fibroids), while over 20 million men face prostate issues with many unaware of minimally invasive options. Learn how these outpatient procedures offer 90% success rates with only 4-5 days recovery versus weeks for surgery, helping patients avoid premature menopause, sexual dysfunction, and other serious complications.Key Highlights:• The dramatic difference between fibroid embolization (4-5 days recovery) vs. hysterectomy (4-6 weeks recovery)• Why 300,000+ women annually may be having unnecessary hysterectomies• The hidden dangers of early menopause and long-term health consequences• How prostate enlargement affects 60% of men over 60 and 80% of men over 80• The three major risks of prostate surgery that embolization avoids• Why over 230 physicians have chosen Dr. Bhatia for their own treatment• Prostate embolization's impressive 5-year efficacy rates comparable to surgical options• Dr. Bhatia's mission to "save your organs" from unnecessary removalWhy You Should WatchThis episode contains potentially life-saving information for anyone facing fibroid or prostate issues. Dr. Bhatia shares alternatives to major surgery that preserve vital organs and maintain quality of life with dramatically shorter recovery times and fewer side effects. Whether for yourself or someone you love, this knowledge empowers you to make truly informed healthcare decisions about benign conditions that affect millions of Americans.

This podcast is brought to you by Outcomes Rocket, your exclusive healthcare marketing agency. Learn how to accelerate your growth by going to⁠ outcomesrocket.com How do you build AI that actually feels loving to the people it serves? In this episode, Dr. Apurv Gupta, Founder and Board Member of A Loving Organization, explains that the Loving Organization Consortium aims to bring more love and compassion into healthcare by improving nine interconnected systems, people, processes, culture, workflows, and especially technology, through a framework called INTEGRATE. He and Ed Gaudet discuss how “loving AI” can ease clinician burden through tools like ambient listening, workflow automation, and emerging burnout-prediction technology, while emphasizing that tech alone is only 10–20% of the solution. Dr. Gupta stresses that effective technology requires human oversight, governance, feedback loops, and involvement from clinicians and patients in the design process. He highlights that organizations often miss these elements due to lack of awareness and capabilities, which the INTEGRATE framework seeks to build. Ultimately, he argues that love must be the foundational intention shaping systems, leadership, and AI, because technology is neutral but becomes “loving” only when embedded in a loving human environment. Tune in to explore how compassion-driven systems and “loving AI” can transform clinician well-being, patient care, and the future of healthcare! Resources Connect with and follow Dr. Apurv Gupta on LinkedIn. Follow A Loving Organization on LinkedIn and visit their website! Last Apurv Gupta RNS episode here!

Clonal mast cell disease is often missed because symptoms vary from person to person, tryptase levels can be normal, and bone marrow biopsies are hard to get. For some people, unexplained or very severe anaphylaxis may be an early sign of a clonal mast cell disease. In this episode, we review “Prevalence of KIT D816V in anaphylaxis or systemic mast cell activation,” published in October 2025 in the Journal of Allergy and Clinical Immunology. This paper, known as the PROSPECTOR trial, is looking at how often the KIT D816V mutation can be found using a blood test in adults who have had anaphylaxis or systemic mast cell activation symptoms. We break down why KIT D816V matters, how it connects to systemic mastocytosis, why HaT needs to be considered, and how newer blood tests may help doctors catch clonal mast cell disease earlier. What we cover in our episode about KIT D816V and anaphylaxis: Setting the stage: Understanding mast cell activation and anaphylaxis. Why KIT D816V matters: How this mutation fits into clonal mast cell disease, what blood testing can reveal, and when doctors still turn to a bone marrow biopsy. Making sense of tryptase and hereditary alpha-tryptasemia (HaT): Why baseline tryptase, the “20% + 2” rule, and HaT can make screening more complicated than it seems. What the PROSPECTOR trial uncovered: How often KIT D816V appeared in people with anaphylaxis, and other results on tryptase and HaT. How this helps patients: What these findings mean for anyone with unexplained or severe anaphylaxis, and how doctors combine KIT testing, tryptase, HaT, and symptoms to decide on next steps. Other podcast episodes about mast cell disease: Ep. 127: Management of indolent mastocytosis - A clinical yardstick Ep. 126: Management of mast cell activation syndrome - A clinical yardstick Ep. 121: Avapritinib vs Placebo in Indolent Systemic Mastocytosis - PIONEER Trial Ep. 118: The ISM Disconnect - Do Patients and Providers Agree on Symptom Control? Ep. 70 How do stress and low histamine diets impact mast cell disease? Ep. 63: Mast Cell Diseases & Systemic Mastocytosis: The Basic Science Ep. 65: The Symptoms and Triggers of Mast Cell Disease *********** The Itch Review, hosted by Dr. Gupta, Kortney, and Dr. Blaiss, explores allergy and immunology studies, breaking down complex research in conversations accessible to clinicians, patients, and caregivers. Each episode provides key insights from journal articles and includes a one-page infographic in the show notes for easy reference. *********** Made in partnership with The Allergy & Asthma Network. Thanks to Blueprint Medicines for sponsoring today's episode.  This podcast is for informational purposes only and does not substitute professional medical advice. Always consult with your healthcare provider for any medical concerns.

Jason Kander and Ravi Gupta break down Trump's latest spiral after posting 160 times on Truth Social and then appearing to fall asleep in a cabinet meeting. They examine the escalating “Double Tap” scandal, from Pete Hegseth's shifting explanations to sharp criticism from Megyn Kelly, Brit Hume, Marco Rubio, and Rand Paul as Republicans contradict themselves in real time. The hosts also dig into Trump's shocking pardon of former Honduran President Juan Orlando Hernández and his commutation of private-equity CEO David Gentile, highlighting the uproar over freeing major drug traffickers and white-collar criminals. Kander and Gupta then turn to the National Guard shooting involving an Afghan asylee, breaking down the rigorous vetting process, the mental-health failures that followed, and why this was a support-system breakdown rather than an immigration failure. All that plus a quick look at the Tennessee special results on the podcast that helps you, the majority of Americans who believe in progress, convince your conservative friends and family to join us—this is Majority 54! Nutrafol: Get results you can run your fingers through! For a limited time, Nutrafol is offering our listeners ten dollars off your first month's subscription and free shipping when you go to https://Nutrafol.com and enter the promo code MAJORITY. Dupe: For a limited time, the first 10,000 people who go to https://Dupe.com/majority will instantly get 500 Dupe Points IndaCloud: If you're 21 or older, get 25% OFF your first order + free shipping @IndaCloud with code MAJORITY at https://inda.shop/MAJORITY! #indacloudpod Hexclad: Get 10% off at https://HexClad.com/MAJORITY Subscribe to Ravi's Substack: https://realravigupta.substack.com/ For more information visit: https://www.ravimgupta.com/analog Shout out to https://immigrantslist.org where people can donate to help get real immigration facts out! Majority 54 on Twitter: https://twitter.com/majority54 Jason on Twitter: https://twitter.com/JasonKander Jason on Instagram: https://www.instagram.com/jasonkander/ Ravi on Twitter: https://twitter.com/RaviMGupta Ravi on Instagram: https://www.instagram.com/ravimgupta Ravi on Youtube: https://www.youtube.com/@LostDebate Remember to subscribe to ALL the MeidasTouch Network Podcasts: MeidasTouch: https://www.meidastouch.com/tag/meidastouch-podcast Legal AF: https://www.meidastouch.com/tag/legal-af MissTrial: https://meidasnews.com/tag/miss-trial The PoliticsGirl Podcast: https://www.meidastouch.com/tag/the-politicsgirl-podcast The Influence Continuum: https://www.meidastouch.com/tag/the-influence-continuum-with-dr-steven-hassan Mea Culpa with Michael Cohen: https://www.meidastouch.com/tag/mea-culpa-with-michael-cohen The Weekend Show: https://www.meidastouch.com/tag/the-weekend-show Burn the Boats: https://www.meidastouch.com/tag/burn-the-boats Majority 54: https://www.meidastouch.com/tag/majority-54 Political Beatdown: https://www.meidastouch.com/tag/political-beatdown On Democracy with FP Wellman: https://www.meidastouch.com/tag/on-democracy-with-fpwellman Uncovered: https://www.meidastouch.com/tag/maga-uncovered Learn more about your ad choices. Visit megaphone.fm/adchoices

On Wednesday, the government withdrew a mandate requiring smartphone makers to preload the Sanchar Saathi on all new devices. Several privacy advocates had raised concerns over how the app may impact users' rights. But is the app the answer to the increasing cyber crime in the country? And how does the app impact citizens' privacy? Founder-Director of Internet Freedom Foundation, Apar Gupta explains, in conversation with Senior Assistant Editor, Apoorva Mandhani.

Today on Beating Cancer Daily, Saranne explores the concept of FOMO, Fear of Missing Out, and how it uniquely affects cancer patients. Drawing from personal experiences and referencing a 2021 study from the World Journal of Clinical Cases by Gupta and Sharma, Saranne explains how FOMO can lead to anxiety, disrupted sleep, and emotional issues, especially when compounded by the rigorous demands of cancer treatment. She emphasizes the importance of self-preservation and introduces the concept of JOMO (Joy of Missing Out) as a healthier mindset. By creating an inner life filled with joy, one doesn't need to keep up with social expectations and can instead focus on what truly brings peace and happiness. "Forget others, me only." – Saranne Today on Beating Cancer Daily: ·     FOMO stands for Fear of Missing Out, and social media often exacerbates it.·     A 2021 study identified multiple negative impacts of FOMO, including anxiety and reduced physical well-being.·     For cancer patients, FOMO can add unnecessary stress during treatment, making it crucial to manage social engagements wisely.·     JOMO — Joy of Missing Out — is about finding contentment in one's inner life rather than external activities.·     Self-preservation is key during cancer treatment; knowing when to rest and recharge is vital.·     Practical strategies for combating FOMO include journaling, meditation, and turning off social media.·     Scheduling social connections via digital means can help maintain relationships without the physical strain of going out.·     Tools like ComedyCures LaughLine offer daily humor, aiding in emotional well-being. Resources Mentioned:ComedyCures Foundationhttps://www.comedycures.org2025 People's Choice Podcast Awards Finalist Ranked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025, and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 Beating Cancer Daily is listened to in over 130 countries across 7 continents and features over 390 original daily episodes hosted by Stage IV survivor  Saranne Rothberg.   To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne 

This week, we're joined by Ishan Gupta, co-founder of Juicebox — a company redefining how recruiting works in an AI-native world.Ishan shares how they pivoted from earlier ideas to focus on the highest value part of hiring: identifying the right people and getting them into process. With Juicebox, you describe what you want in natural language and the platform searches more than 800 million professional profiles, surfaces the best matches, and engages candidates through recruiting agents.Their breakout feature, Autopilot, uses LLMs to semantically evaluate and stack rank candidates based on nuanced criteria, which quickly drove organic growth and strong PMF. We talk about why their data makes the product so sticky, how they see recruiting evolving over the next five years, what led them to raise their Series A, and the culture they are building around moving fast and being intellectually honest.Ishan also shares what they are building next with their memory layer, which will make it clear what the AI is learning over time and how it improves future searches.Episode chapters:1:44 - Competitive programming4:35 - Choosing the company name5:55 - YC and the pivot8:00 - How Juicebox differs from traditional recruiting9:51 - The killer feature14:30 - What makes the product sticky17:15 - Is recruiting a zero sum game19:10 - The macro view of hiring22:05 - Raising a later Series A24:10 - Product expansion26:45 - Quick fire round This episode is brought to you by Grata, the leading deal sourcing platform for private equity. Grata's AI powered search, investment grade data, and intuitive workflows help you find and win the right deals faster. Visit grata.com to book a demo.This episode is also sponsored by Overlap, the AI powered app that uses LLMs to surface the best moments from any podcast. Overlap reads full transcripts, finds the most relevant clips, and stitches them into a personalized stream of insights. Tap into podcasts as a real information source with Overlap 2.0, now available on the App Store.

The Visibility Equation is a weekly podcast series that demystifies the art of professional visibility. It is designed to empower ambitious product leaders (and leaders across tech) to own their narratives and amplify their impact. Through in-depth conversations with accomplished leaders in product management, design, and engineering, we'll delve into practical strategies, inspiring stories, and actionable insights to help listeners build visibility without falling into the “humble brag” trap.00:00 Introduction to The Visibility Equation01:25 The Importance of Visibility02:59 Surbhi's Personal Journey06:59 Strategies for Building Visibility11:25 Why Visibility Matters Now14:55 About the Interviews18:20 First Episode PreviewResources•

As a practicing neurosurgeon and CNN's chief medical correspondent, Dr. Sanjay Gupta can spot false health claims from a mile away. Still, he recently became the unwitting subject of an AI disinformation campaign that used his likeness to sell sham health products. On today's episode, Dr. Gupta shares what happened, and offers tips to avoid getting duped by medical misinformation online.  Learn more about your ad choices. Visit podcastchoices.com/adchoices

Periodically on Trust Me, I Know What I'm Doing, we share a SPOTLIGHT conversation and feature brief chats with an individual from the community about a very special topic or a unique endeavor. Now, we live in an era where lessons and memory of the past seems to get crystallized and presented with increasing speed and accuracy. But perhaps now more than ever, it's equally important to actually pause and reflect and synthesize and process our experiences as rich human lessons to share and express to the world. Vinita Gupta is a pioneering entrepreneur and technology leader who made history as the first woman of Indian origin to take a company public in the US. With over 40 years in Silicon Valley, she's a celebrated leader in engineering and innovation, and a staunch advocate for women in tech. To add to that, Vinita is an internationally recognized bridge champion, an artist, and a writer. And she recently wrote about her multifaceted journey in her memoir, The Woman Indeed: Road to IPO, Bridge Tables, and Beyond, which is available everywhere.Big shout out to INDIASPORA for sparking this one, to anyone who is sick of the six seven trend, to the American South Asian Network at americansouthasiannetwork.comIt's Thanksgiving week in the US, so please, find someone in need and consciously practice a random act of kindness!

Please enjoy this encore of Career Notes. Co-founder and CTO of Virsec, Satya Gupta shares his story of how he has over 25 years of expertise in embedded systems, network security and systems architecture. He also talks about how a colleague of his told him something that resinated with him, he said " that was really a remarkable statement that I heard from that person. You rise to the point where you can actually contribute." He also discusses how he got into the startup atmosphere and how different scenarios in his life helped to lead him to the successful man he has become in the cyber community. We thank Satya for sharing his story. Learn more about your ad choices. Visit megaphone.fm/adchoices

Ravi Gupta and Stephen Webber break down Congress's explosive vote to release the Epstein files as Trump abruptly reverses course at the last minute, raising questions about whether compromising material is being withheld. They analyze accusations from Mark Epstein that the files are already being scrubbed, Rep. Thomas Massie's threat to read names on the House floor, and the sweeping disclosure requirements included in the Epstein Files Transparency Act. Kander and Gupta also dive into the political chaos surrounding Speaker Mike Johnson's demand for last-minute changes that the Senate flatly rejected, Trump's meltdown when pressed on why he didn't release the files himself, and the escalating infighting on the right—from MTG's attacks on Trump to Megyn Kelly's soft-pedaling of Epstein's crimes to new reporting that the White House intervened on behalf of Andrew Tate. Plus, they discuss the stunning court ruling striking down Texas's redistricting maps after a DOJ-induced legal fiasco. This and more on the podcast that helps you, the majority of Americans who believe in progress, convince your conservative friends and family to join us—this is Majority 54! Hiya Health: Go to https://HiyaHealth.com/MAJORITY and get your kids the full-body nourishment they need to grow into healthy adults. Dupe: For a limited time, the first 10,000 people who go to https://Dupe.com/majority will instantly get 500 Dupe Points Found: Join thousands of small business owners simplifying their finances—open your FREE Found account now at https://found.com Hims: Thanks to HIMS! Start your free online visit today at https://hims.com/majority for your personalized ED treatment options Subscribe to Ravi's Substack: https://realravigupta.substack.com/ For more information visit: https://www.ravimgupta.com/analog Majority 54 on Twitter: https://twitter.com/majority54 Jason on Twitter: https://twitter.com/JasonKander Jason on Instagram: https://www.instagram.com/jasonkander/ Ravi on Twitter: https://twitter.com/RaviMGupta Ravi on Instagram: https://www.instagram.com/ravimgupta Ravi on Youtube: https://www.youtube.com/@LostDebate Remember to subscribe to ALL the MeidasTouch Network Podcasts: MeidasTouch: https://www.meidastouch.com/tag/meidastouch-podcast Legal AF: https://www.meidastouch.com/tag/legal-af MissTrial: https://meidasnews.com/tag/miss-trial The PoliticsGirl Podcast: https://www.meidastouch.com/tag/the-politicsgirl-podcast The Influence Continuum: https://www.meidastouch.com/tag/the-influence-continuum-with-dr-steven-hassan Mea Culpa with Michael Cohen: https://www.meidastouch.com/tag/mea-culpa-with-michael-cohen The Weekend Show: https://www.meidastouch.com/tag/the-weekend-show Burn the Boats: https://www.meidastouch.com/tag/burn-the-boats Majority 54: https://www.meidastouch.com/tag/majority-54 Political Beatdown: https://www.meidastouch.com/tag/political-beatdown On Democracy with FP Wellman: https://www.meidastouch.com/tag/on-democracy-with-fpwellman Uncovered: https://www.meidastouch.com/tag/maga-uncovered Learn more about your ad choices. Visit megaphone.fm/adchoices

The FDA is planning to remove the “black box” warning from many hormone treatments for menopause -- a major shift that could change care for millions of women in this country. On this week's Paging Dr. Gupta, we break down what who this treatment could help and what you still need to know about its risks.  This episode was produced by Jennifer Lai with assistance from Kyra Dahring and Leying Tang.   Showrunner: Amanda Sealy  Senior Producer: Dan Bloom  Technical Director: Dan Dzula  Executive Producer: Steve Lickteig Learn more about your ad choices. Visit podcastchoices.com/adchoices

Jason Kander and Ravi Gupta break down the explosive release of newly uncovered Jeffrey Epstein emails, including messages referencing Donald Trump and Ghislaine Maxwell that raise fresh questions about what the former president knew and when. They analyze the media and political fallout, how these revelations intersect with ongoing legal scrutiny, and what Epstein's 2019 emails to journalist Michael Wolff reveal about his ties to Mar-a-Lago. Kander and Gupta also unpack the end of the government shutdown and whether Democrats “caved.” Plus, they dive into Trump's eyebrow-raising interview with Laura Ingraham on inflation, and the escalating MAGA civil war—Ben Shapiro feuding with Megyn Kelly, right-wing influencers accusing each other of betrayal, and prominent conservatives warning of a full-blown ideological collapse. This and more on the podcast that helps you, the majority of Americans who believe in progress, convince your conservative friends and family to join us—this is Majority 54! Nutrafol: Get results you can run your fingers through! For a limited time, Nutrafol is offering our listeners ten dollars off your first month's subscription and free shipping when you go to https://Nutrafol.com and enter the promo code MAJORITY. Shopify: Sign up for your one-dollar-per-month trial and start selling today at https://SHOPIFY.com/majority Dupe: For a limited time, the first 10,000 people who go to https://Dupe.com/MAJORITY will get 500 Dupe Points instantly—redeemable for gift cards, no catch. Done With Debt: Go to https://DONEWITHDEBT.com and talk with one of their specialists, FOR FREE! Majority 54 on Twitter: https://twitter.com/majority54 Jason on Twitter: https://twitter.com/JasonKander Jason on Instagram: https://www.instagram.com/jasonkander/ Ravi on Twitter: https://twitter.com/RaviMGupta Ravi on Instagram: https://www.instagram.com/ravimgupta Ravi on Youtube: https://www.youtube.com/@LostDebate Remember to subscribe to ALL the MeidasTouch Network Podcasts: MeidasTouch: https://www.meidastouch.com/tag/meidastouch-podcast Legal AF: https://www.meidastouch.com/tag/legal-af MissTrial: https://meidasnews.com/tag/miss-trial The PoliticsGirl Podcast: https://www.meidastouch.com/tag/the-politicsgirl-podcast The Influence Continuum: https://www.meidastouch.com/tag/the-influence-continuum-with-dr-steven-hassan Mea Culpa with Michael Cohen: https://www.meidastouch.com/tag/mea-culpa-with-michael-cohen The Weekend Show: https://www.meidastouch.com/tag/the-weekend-show Burn the Boats: https://www.meidastouch.com/tag/burn-the-boats Majority 54: https://www.meidastouch.com/tag/majority-54 Political Beatdown: https://www.meidastouch.com/tag/political-beatdown On Democracy with FP Wellman: https://www.meidastouch.com/tag/on-democracy-with-fpwellman Uncovered: https://www.meidastouch.com/tag/maga-uncovered Coalition of the Sane: https://meidasnews.com/tag/coalition-of-the-sane Learn more about your ad choices. Visit megaphone.fm/adchoices

One of the nation's most influential labor leaders, Randi Weingarten, joins Dr. Vin Gupta of Meidas Health to discuss the ongoing government shutdown, its impact on healthcare access for everyday Americans, and the timely release of her new book, Why Fascists Fear Teachers. Learn more about your ad choices. Visit megaphone.fm/adchoices

Jason Kander and Ravi Gupta break down the Democrats' dominating victories in Virginia and New Jersey, where early returns and strong turnout have analysts like Harry Enten and Dave Wasserman predicting Democrats could be favored to retake the House in 2026. They unpack how the results exposed cracks in the GOP coalition, with MAGA influencers blaming “weak” Republican candidates and moderates pointing to Trump's shutdown chaos and record-low approval rating of -18%. Kander and Gupta also examine how Democratic leaders from Gavin Newsom to Bill Ferguson framed the victories as proof that competence and optimism still win, even as Republicans melted down online over their losses. Plus, they analyze the high-stakes Supreme Court case that could unravel Trump's global tariffs, what it means for the U.S. economy, and how it fits into a broader crisis of Trump's leadership. This and more on the podcast that helps you, the majority of Americans who believe in progress, convince your conservative friends and family to join us—this is Majority 54! Hims: Thanks to HIMS! Start your free online visit today at https://hims.com/majority for your personalized ED treatment options Hexclad: Get 10% off at https://HexClad.com/MAJORITY Support Diana and Jason Kander's November Challenge: https://secure.givelively.org/donate/veterans-community-project/diana-and-jason-kander-november-challenge-30k-in-30-days Majority 54 on Twitter: https://twitter.com/majority54 Jason on Twitter: https://twitter.com/JasonKander Jason on Instagram: https://www.instagram.com/jasonkander/ Ravi on Twitter: https://twitter.com/RaviMGupta Ravi on Instagram: https://www.instagram.com/ravimgupta Ravi on Youtube: https://www.youtube.com/@LostDebate Remember to subscribe to ALL the MeidasTouch Network Podcasts: MeidasTouch: https://www.meidastouch.com/tag/meidastouch-podcast Legal AF: https://www.meidastouch.com/tag/legal-af MissTrial: https://meidasnews.com/tag/miss-trial The PoliticsGirl Podcast: https://www.meidastouch.com/tag/the-politicsgirl-podcast The Influence Continuum: https://www.meidastouch.com/tag/the-influence-continuum-with-dr-steven-hassan Mea Culpa with Michael Cohen: https://www.meidastouch.com/tag/mea-culpa-with-michael-cohen The Weekend Show: https://www.meidastouch.com/tag/the-weekend-show Burn the Boats: https://www.meidastouch.com/tag/burn-the-boats Majority 54: https://www.meidastouch.com/tag/majority-54 Political Beatdown: https://www.meidastouch.com/tag/political-beatdown On Democracy with FP Wellman: https://www.meidastouch.com/tag/on-democracy-with-fpwellman Uncovered: https://www.meidastouch.com/tag/maga-uncovered Coalition of the Sane: https://meidasnews.com/tag/coalition-of-the-sane Learn more about your ad choices. Visit megaphone.fm/adchoices

Americans are buying more organic food than ever, whether it's apples from Washington or avocados from Mexico. But when that label says “organic,” especially on something grown thousands of miles away, how do you know it's truly organic? We get to the bottom of that on this week's Paging Dr. Gupta. Plus, grounding sheets claim to help with sleep and pain...but does the science back that up?  This episode was produced by Jennifer Lai with assistance from Leying Tang. Showrunner: Amanda Sealy  Senior Producer: Dan Bloom  Technical Director: Dan Dzula  Learn more about your ad choices. Visit podcastchoices.com/adchoices

Jason Kander and Ravi Gupta break down Donald Trump's collapsing approval numbers, as new polling from The Economist shows his net rating falling to -18, the lowest it has ever been—even lower than any point in his first term. They discuss what's driving the drop, from voter fatigue to economic fallout, and what it means for Trump's reelection odds. Kander and Gupta also dive into a new Reuters report revealing the Trump family raked in over $800 million from crypto ventures in just the first half of 2025, even as Trump pardoned Binance CEO CZ Zhao in a move critics call blatant corruption, analyzing how the pardon fits into Trump's broader pattern of rewarding allies and dismantling financial oversight. Then, they turn to Washington's ongoing chaos as the government shutdown drags on, with Marjorie Taylor Greene turning on Speaker Mike Johnson and demanding Republicans unveil a real health care plan, and examine Democrats' surprising restraint in Illinois and Maryland redistricting fights, and how internal debates over power and principle are shaping both parties' futures. Plus, they break down the Senate's rare bipartisan rebuke of Trump's Brazil tariffs, a sign that even some Republicans are losing patience with his economic nationalism. This and more on the podcast that helps you, the majority of Americans who believe in progress, convince your conservative friends and family to join us—this is Majority 54! Hims: Thanks to HIMS! Start your free online visit today at https://hims.com/majority for your personalized ED treatment options Hexclad: Get 10% off at https://HexClad.com/MAJORITY Done With Debt: Go to https://DONEWITHDEBT.com and talk with one of their specialists, FOR FREE Majority 54 on Twitter: https://twitter.com/majority54 Jason on Twitter: https://twitter.com/JasonKander Jason on Instagram: https://www.instagram.com/jasonkander/ Ravi on Twitter: https://twitter.com/RaviMGupta Ravi on Instagram: https://www.instagram.com/ravimgupta Ravi on Youtube: https://www.youtube.com/@LostDebate Remember to subscribe to ALL the MeidasTouch Network Podcasts: MeidasTouch: https://www.meidastouch.com/tag/meidastouch-podcast Legal AF: https://www.meidastouch.com/tag/legal-af MissTrial: https://meidasnews.com/tag/miss-trial The PoliticsGirl Podcast: https://www.meidastouch.com/tag/the-politicsgirl-podcast The Influence Continuum: https://www.meidastouch.com/tag/the-influence-continuum-with-dr-steven-hassan Mea Culpa with Michael Cohen: https://www.meidastouch.com/tag/mea-culpa-with-michael-cohen The Weekend Show: https://www.meidastouch.com/tag/the-weekend-show Burn the Boats: https://www.meidastouch.com/tag/burn-the-boats Majority 54: https://www.meidastouch.com/tag/majority-54 Political Beatdown: https://www.meidastouch.com/tag/political-beatdown On Democracy with FP Wellman: https://www.meidastouch.com/tag/on-democracy-with-fpwellman Uncovered: https://www.meidastouch.com/tag/maga-uncovered Coalition of the Sane: https://meidasnews.com/tag/coalition-of-the-sane Learn more about your ad choices. Visit megaphone.fm/adchoices

Ravi Gupta and guest host Stephen Webber, filling in for Jason Kander, start with some rare good news for Democrats, breaking down Harry Enten's latest analysis showing early positive signs in New Jersey's returns and what that might mean heading into 2026. They unpack data showing Democrats cutting into the GOP's mail ballot lead, rising early vote enthusiasm, and a noticeable shift in party energy as figures like Senator Schatz test new messages aimed at revving up the base. Gupta and Webber also highlight the bizarre week for Republican leadership, as Speaker Johnson defends the president's crude social media posts and dodges questions about pardoning a January 6 rioter, while Ted Cruz stokes culture war outrage over pro-democracy protests. Meanwhile, Trump spends his days golfing, demanding DOJ payouts, and posting rants as his shutdown drags on and GOP hypocrisy explodes—from private jet subsidies to ballroom renovations. The hosts then turn to North Carolina's redistricting fight, stalled Democratic donor activity, and the brewing Maine Senate race, before diving into escalating tensions with Venezuela, confusion over U.S. beef imports, and Trump's latest chaos at the DOJ. This and more on the podcast that helps you, the majority of Americans who believe in progress, convince your conservative friends and family to join us—this is Majority 54! NUTRAFOL: Get results you can run your fingers through! For a limited time, Nutrafol is offering our listeners ten dollars off your first month's subscription and free shipping when you go to https://Nutrafol.com and enter the promo code MAJORITY. INDACLOUD: If you're 21 or older, get 25% OFF your first order + free shipping @IndaCloud with code MAJORITY at https://inda.shop/MAJORITY! #indacloudpod DUPE: Go to https://dupe.com today and find similar products for less. It's 100% free to use! Stop wasting money on brand names and start saving with https://dupe.com today. HIMS: Thanks to HIMS! Start your free online visit today at https://hims.com/majority for your personalized ED treatment options Majority 54 on Twitter: https://twitter.com/majority54 Jason on Twitter: https://twitter.com/JasonKander Jason on Instagram: https://www.instagram.com/jasonkander/ Ravi on Twitter: https://twitter.com/RaviMGupta Ravi on Instagram: https://www.instagram.com/ravimgupta Ravi on Youtube: https://www.youtube.com/@LostDebate  Remember to subscribe to ALL the MeidasTouch Network Podcasts: MeidasTouch: https://www.meidastouch.com/tag/meidastouch-podcast Legal AF: https://www.meidastouch.com/tag/legal-af MissTrial: https://meidasnews.com/tag/miss-trial The PoliticsGirl Podcast: https://www.meidastouch.com/tag/the-politicsgirl-podcast  The Influence Continuum: https://www.meidastouch.com/tag/the-influence-continuum-with-dr-steven-hassan Mea Culpa with Michael Cohen: https://www.meidastouch.com/tag/mea-culpa-with-michael-cohen The Weekend Show: https://www.meidastouch.com/tag/the-weekend-show Burn the Boats: https://www.meidastouch.com/tag/burn-the-boats Majority 54: https://www.meidastouch.com/tag/majority-54  Political Beatdown: https://www.meidastouch.com/tag/political-beatdown On Democracy with FP Wellman: https://www.meidastouch.com/tag/on-democracy-with-fpwellman  Uncovered: https://www.meidastouch.com/tag/maga-uncovered Coalition of the Sane: https://meidasnews.com/tag/coalition-of-the-sane Learn more about your ad choices. Visit megaphone.fm/adchoices