BMJ Best Practice Podcast

There are concerns that junior healthcare professionals do not use decision support as they don't see senior staff using it. There are concerns that seniors don't use clinical decision support as they worry about looking things up people in front of people. So a complex issue to discuss. To find out more about this, listen to this interview with Dr Tom Foley, Consultant Child and Adolescent Psychiatrist with expertise in digital health.

Adhesive capsulitis affects 2% to 5% of the population. It is slightly more common in women than in men, and is most common in people between the ages of 40 and 70. And it can cause a range of problems - including pain, stiffness, and loss of function. So it is important that we get the diagnosis and management of this condition right. To give us more details about this problem and what we can do about it, Kieran Walsh, Clinical Director at BMJ, speaks with Professor Lance LeClerc, Associate Professor of Orthopedic Surgery at Vanderbilt University Medical Centre in Nashville. For more on adhesive capsulitis, visit BMJ Best Practice: bestpractice.bmj.com/topics/en-gb/1043 Competing interests: None

Gastro-oesophageal reflux disease (GORD) is a common condition that affects between 10% and 30% of people in developed countries. There can be a range of complications from haemorrhage to stricture to Barrett's oesophagus. So it is important that we get the diagnosis and management of this condition right. In this BMJ Best Practice podcast on GORD, Kieran Walsh talks with Dr Andres Carrion, Associate Professor of Clinical Medicine at The Division of Digestive Health and Liver Diseases in University of Miami Miller School of Medicine. For more on GORD, visit BMJ Best Practice: bestpractice.bmj.com/topics/en-gb/82 Competing interests: None

Snoring is common. In the 30- to 35-year-old age group, 20% of men and 5% of women snore. By 60, 60% of men and 40% of women will snore habitually. And snoring can affect the quality of life - of both the patient and their partner. In this BMJ Best Practice podcast on snoring, Kieran Walsh talks with Dr Showkat Mirza, Consultant in Otorhinolaryngology and Head & Neck Surgery, Sheffield Teaching Hospitals NHS Trust. For more on snoring, visit BMJ Best Practice: bestpractice.bmj.com/topics/en-gb/1035 Competing interests: SM has no competing interests

Age-related macular degeneration is the third most common cause of visual impairment worldwide. The main risk is advanced disease and resultant visual loss. Prompt diagnosis and treatment can make a big difference to the outcome - so it is vital that we get the diagnosis and management of this condition right. In this BMJ Best Practice podcast on macular degeneration, Kieran Walsh talks with Dr. Sajjad Mahmood, Consultant Ophthalmic Surgeon, Medical Retina Specialist, and Honorary Clinical Lecturer at the University of Manchester. For more on age-related macular degeneration, visit BMJ Best Practice: bestpractice.bmj.com/topics/en-gb/554 Competing interests: SM has done consultancy work and received honoraria for lecturing and travel from Bayer Pharmaceuticals and Novartis. He has also been a principal investigator for clinical trials on behalf of Bayer, Novartis, and Roche.

The prevalence of cluster headache is about one in 500. In people coming to a headache clinic, the prevalence is about 10%. Cluster headaches are excruciating and incapacitating, and affect quality of life. Prompt diagnosis and treatment can make a big difference to the outcome - so it is vital that we get the diagnosis and management of this condition right. In this BMJ Best Practice podcast on cluster headache, Kieran Walsh talks with Professor Amaal Starling, Associate Professor of Neurology at the Department of Neurology in the Mayo Clinic. Further resources: clusterbusters.org/. Competing interests: AS has received consulting fees from AbbVie, Allergan, Amgen, Axsome Therapeutics, Everyday Health, Lundbeck, Med-IQ, Medscape, Neurolief, Satsuma, and WebMD. We release episodes fortnightly.

Spinal cord compression is an extremely serious disorder that can have devastating consequences. These include weakness of the legs, bladder and bowel dysfunction, and loss of sensation. Rapid diagnosis and treatment can make a big difference to the outcome - so it is vital that we get the diagnosis and management of this condition right. In this BMJ Best Practice podcast on spinal cord compression, Kieran Walsh talks with Professor Kenneth Casey, Clinical Associate Professor in Neurosurgery at Michigan State University and Clinical Associate Professor in Physical Medicine and Rehabilitation at Wayne State University School of Medicine. Competing interests: none declared We release episodes fortnightly.

Halitosis is common and can affect people of all ages. Severe halitosis is less common but it can affect confidence and quality of life. It can even result in social isolation. So it is important that we get the diagnosis and management of this condition right. In this BMJ Best Practice podcast on halitosis, Kieran Walsh talks with Professor Stephen Porter, Director of the UCL Eastman Dental Institute in London. Competing interests: none declared

We release episodes fortnightly. Osteoarthritis is the most common form of arthritis. It is more common in women than in men, with incidence increasing sharply around the age of 50. And it can cause complications - including the inability to perform activities of daily living and spinal stenosis in cervical and lumbar osteoarthritis. So it is vital that we get the diagnosis and management of this condition right. In this BMJ Best Practice podcast on osteoarthritis, Kieran Walsh talks to Fadi Badlissi, Assistant Professor at Harvard Medical School and Director of the Musculoskeletal Medicine Unit at Beth Israel Deaconess Medical Center in Boston. Competing interests: None

Podcast title: Data, AI, oncology, and patients Data, AI, oncology, and patients are a wide range of subjects to be addressed in one podcast. Individually they are big topics and when you put them together you really get to high levels of complexity. In this BMJ Best Practice podcast, Kieran Walsh delves into all these topics with Dr Arun Sujenthiran, Senior Medical Director and UK Clinical Lead at Flatiron Health. Flatiron Health is a healthtech company that specialises in data science and oncology. Competing interests: AS is an employee of Flatiron Health Inc, an independent subsidiary of Roche, and holds stock in Roche.

We release episodes fortnightly. Stroke is the fourth and fifth leading cause of death in the UK and US, respectively. There are more than 100,000 strokes in the UK every year. And approximately 10% to 15% of all ischaemic strokes are associated with carotid artery stenosis. So it is important that we get the diagnosis and management of this condition right. In this BMJ Best Practice podcast on carotid artery stenosis, Kieran Walsh talks to Brajesh Lal, Professor of Vascular Surgery, University of Maryland School of Medicine and Professor of Neurology, Mayo Clinic. Competing interests: None

Bell's palsy: an update on diagnosis and management Bell's palsy is the most common unilateral facial palsy in adults. It is most prevalent in people between 15 and 45 years of age. And it can cause a range of complications - including ongoing facial weakness, keratoconjunctivitis sicca, exposure keratopathy, and ectropion. So it is important that we get the diagnosis and management of this condition right. In this BMJ Best Practice podcast, Kieran Walsh talks with Professor Matthew Miller about Bell's palsy. Matt is Assistant Professor Otolaryngology and Head and Neck Surgery, University of North Carolina Chapel Hill. Competing interests: none declared

Hypothermia is a serious condition - it can cause rhabdomyolysis, electrolyte disturbances, and cardiac arrhythmias. It can also kill. In the UK, the annual number of hypothermia-related deaths is about 300. And in countries with colder climates, the numbers are far higher. So it is important that we get the diagnosis and management of this condition right. In this BMJ Best Practice podcast, Kieran Walsh talks to Dr Alexander Alexiou, Emergency Medicine Consultant, Barts Health NHS Trust about hypothermia. Competing interests: none declared

Rosacea is a common disorder. Studies suggest a prevalence of 5% for women and 4% for men. And rosacea can cause a range of problems including papules and pustules, telangiectasias, and eye problems. So it is important that we get the diagnosis and management of this condition right. In this BMJ Best Practice podcast on rosacea, Kieran Walsh talks to Dr Abel Jarell, Dermatologist and Dermatopathologist, Northeast Dermatology Associates, Portsmouth, New Hampshire. Competing interests: none declared

Parkinson's disease Parkinson's disease is a common and serious condition. It is the second most common neurodegenerative disorder in the world - only Alzheimer's disease is more common. And Parkinson's disease can cause a range of complications - from dyskinesias to depression to dementia. So it is important that we get the diagnosis and management of this condition right. In this BMJ Best Practice podcast, Kieran Walsh talks to Delaram Safarpour, Assistant Professor of Neurology at Oregon Health & Science University. Competing interests: DS has received honoraria for participation in advisory boards for Boston Scientific (the manufacturer of Deep Brain Stimulation devices) and Abbvie (the manufacturer of Duopa). She has received consultation fees from Abbott (the manufacturer of Deep Brain Stimulation devices). DS has received an institutional grant and has received an honorarium for lectures from the Parkinson's Study Group.

Data and big data in healthcare are both important and topical. Big data has the potential to transform how we provide healthcare but can also be problematic. There can be problems with how data is captured, cleaned, and corrected or with how we update data. BMJ is playing an increasing role in this field. We have our own BMJ Data Set which provides AI healthcare technologies with current, credible, and AI-ready content. In this BMJ Best Practice podcast on healthcare and data, Kieran Walsh talks to Professor Dipak Kalra, President of The European Institute for Innovation through Health Data.

Herpes zoster: an update on diagnosis and management The annual incidence of herpes zoster in the UK is between 2 and 4 patients per thousand population. It can cause a range of complications including post-herpetic neuralgia, herpes zoster of the eye, and disseminated zoster. So it is important that we get the diagnosis and management of this condition right. In this BMJ Best Practice podcast on herpes zoster, Kieran Walsh talks to Professor Michael Rothberg, Center for Value-Based Care Research, Cleveland Clinic, Cleveland, Ohio. MR declares that he has no competing interests.- The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner's judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Status epilepticus is a serious medical emergency. Fortunately, it is relatively rare but when it does occur it can cause a range of serious complications including focal neurological deficits, cognitive dysfunction, and behavioural problems. So it is important that we get the diagnosis and management of this condition right. In this BMJ Best Practice podcast on status epilepticus, Kieran Walsh talks to Dr. Rajiv Mohanraj, Consultant Neurologist and Honorary Senior Lecturer at the Manchester Centre for Clinical Neurosciences - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner's judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

This BMJ Best Practice podcast is on acute pancreatitis. Acute pancreatitis is a common and serious condition. The incidence in the UK is about 50 per 100,000 per year. And it can cause a range of complications including acute renal failure, pancreatic abscess, and chronic pancreatitis. In this podcast, Kieran Walsh interviews Professor Scott Tenner on acute pancreatitis. Scott is Clinical Professor of Medicine at State University of New York and author of the BMJ Best Practice topic on this condition. BMJ Relevant topic link - https://bestpractice.bmj.com/topics/en-gb/3000118 - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner's judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

COPD or chronic obstructive pulmonary disease is common. The pooled global prevalence is 15% in men and 9% in women. The expanding epidemic of smoking and the ageing of the population means that its prevalence is increasing. And COPD is a serious disease. It is associated with recurrent pneumonia, cor pulmonale, and respiratory failure. In this BMJ Best Practice podcast, Kieran Walsh talks to Dr. Hanna Sandelowsky, GP, Head of Unit at the Academic Primary Healthcare Centre, and Senior Researcher at Karolinska Institutet in Sweden. - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner's judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Transient ischemic attacks are common - in the UK, the US and around the world. And they are important – mainly because of the high risk of stroke following a TIA. The risk of stroke is high in the first 7 days. So it is important to get on with diagnosis, investigations, and management as soon as possible. In this BMJ Best Practice podcast, Kieran Walsh talks to Dr Jennifer Simpson, Vascular Neurologist and Associate Professor in the Department of Neurology at the University of Colorado. - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner's judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Atrial fibrillation is the most common sustained heart rhythm disorder in adults worldwide. The prevalence is between 2% and 4%. If left untreated, atrial fibrillation is a significant risk factor for stroke, myocardial infarction and congestive cardiac failure. So it is important that we get diagnosis and management of this condition right. In this BMJ Best Practice podcast on new-onset atrial fibrillation, Kieran Walsh talks to Bharat Kantharia, Clinical Professor of Medicine, Icahn School of Medicine at Mount Sinai, New York. - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner's judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Axial spondyloarthritis is a chronic progressive inflammatory arthropathy, which ultimately may lead to radiographical changes in the spine and sacroiliac joints. This radiographical stage is known as ankylosing spondylitis. Inflammatory back pain is the hallmark clinical feature. This is defined as back pain that is of insidious onset, is worse in the morning, and improves with exercise. In this podcast, Markku Kauppi, Professor of Rheumatology, Helsinki University, gives a clinical overview of the condition. For more on ankylosing spondylitis, visit BMJ Best Practice: bestpractice.bmj.com/topics/en-gb/366 - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner's judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Ischaemic stroke is a leading cause of morbidity and mortality. The World Health Organization defines stroke as “a clinical syndrome consisting of rapidly developing clinical signs of focal (or global) disturbance of cerebral function, lasting more than 24 hours or leading to death, with no apparent cause other than that of vascular origin”. David Wang, Professor of Neurology, Barrow Neurological Institute, Phoenix, Arizona, gives us a clinical overview of the condition. For more on ischaemic stroke, visit BMJ Best Practice: bestpractice.bmj.com/topics/en-gb/3000114 - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner's judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Essential tremor is characterised by a progressive tremor of the upper extremities, present in posture and action, without other neurological signs or symptoms. The prevalence and incidence increases with age, but the condition can appear in early adulthood in those who have a family history. Sheng-Han Kuo, Assistant Professor of Neurology, Columbia University, New York, gives us an overview of the condition. For more on essential tremor, visit BMJ Best Practice: bestpractice.bmj.com/topics/en-gb/1089 - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner's judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Patients with asthma present with recurrent episodes of shortness of breath, chest tightness, wheezing, or coughing. Examination typically demonstrates an expiratory wheeze; however, in severe asthma there is poor air entry and the chest is silent. Lauren Eggert, Clinical Assistant Professor, Division of Pulmonary, Allergy, and Critical Care Medicine, Stanford University School of Medicine, gives us a clinical overview of the condition. For more on asthma, visit BMJ Best Practice: bestpractice.bmj.com/topics/en-gb/44 - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner's judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Bacterial meningitis represents a life-threatening inflammation of the meninges. Elisabeth Adderson, Associate Member, St. Jude Faculty, Director, Pediatric Infectious Diseases Fellowship Program, St. Jude Children's Research Hospital, Memphis, gives an overview of the condition. For more on bacterial meningitis, visit BMJ Best Practice: bestpractice.bmj.com/topics/en-gb/3000104 - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner's judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Type 1 diabetes mellitus is a metabolic disorder characterised by hyperglycaemia due to absolute insulin deficiency. The condition develops due to destruction of pancreatic beta cells, mostly by immune-mediated mechanisms. In this podcast, Rajesh Garg, Professor of Medicine, University of Miami Miller School of Medicine, gives us an overview of the condition. For more on type 1 diabetes, visit BMJ Best Practice: bestpractice.bmj.com/topics/en-gb/25 - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner's judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Generalised anxiety disorder (GAD) is a common condition defined as chronic, excessive worry for at least six months that causes distress or impairment. Christopher Gale, Research Director and Consultant Psychiatrist, Southern District Health Board, New Zealand gives a clinical overview of the condition. For more on GAD, visit BMJ Best Practice: bestpractice.bmj.com/topics/en-gb/120 - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner's judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Lyme disease is an infectious disease transmitted to humans through the bite of infected ticks. Erythema migrans develops at the site of tick bite usually within 1 to 2 weeks and is a pathognomic feature. Constitutional symptoms such as fever, headache, myalgias, fatigue, and arthralgias may occur. In this podcast, Janak Koirala, Professor of Medicine and Infectious Diseases, Division of Infectious Diseases, Southern Illinois University School of Medicine, gives us an overview of the condition. For more on lyme disease, visit BMJ Best Practice: bestpractice.bmj.com/topics/en-gb/224 - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner's judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Jet lag and sleep phase disorders affect millions of travellers worldwide. Rapid change in time zone produces a constellation of symptoms called jet lag disorder. Symptoms include difficulty initiating and maintaining sleep, reduced daytime alertness, general malaise, and gastrointestinal symptoms. In this podcast, Ashish Adlakha, Assistant Clinical Professor, Neurology and Sleep Medicine, Connecticut Healthcare, gives us a clinical overview. For more on jet lag, visit BMJ Best Practice: bestpractice.bmj.com/topics/en-gb/1017 - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner's judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Post-traumatic stress disorder may develop (either immediately or delayed) following exposure to a stressful event or situation of an exceptionally threatening or catastrophic nature. According to DSM-5, it is characterised by 4 groups of symptoms: intrusion symptoms, avoidance, negative alterations in cognition and mood, and alterations in arousal and reactivity. These symptoms must impair function for a diagnosis to be made. In this podcast, Mathew Hoskins, Consultant Psychiatrist and Clinical Teaching Fellow, Cardiff University, gives us a clinical overview of the disorder. For more on PTSD, visit BMJ Best Practice: https://bestpractice.bmj.com/topics/en-gb/430 - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner's judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Chronic congestive heart failure is a complex clinical syndrome that can result from any structural or functional cardiac disorder that impairs the ability of the ventricle to fill with or eject blood. It is a major and growing public health problem. In this podcast, Syed Wamique Yusuf, FACC, FRCPI Syed Wamique Yusuf, Professor of Medicine, Department of Cardiology, University of Texas MD Anderson Cancer Center, gives a clinical overview of the condition. For more on chronic congestive heart failure, visit BMJ Best Practice: bestpractice.bmj.com/topics/en-gb/61 - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner's judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Kieran Walsh, clinical director at BMJ, asks editors from BMJ Learning and BMJ Best Practice to summarise the latest clinical guidance related to Covid-19. Abigail Davis, GP and section editor, covers the latest evidence around vaccine immunogenicity in different immunosuppressed populations, as well as the use of interleukin-6 inhibitors in COVID-19 patients. And Emma Scott, section editor, updates us on mucormycosis, or black fungus infection in COVID-19 patients. For more, see: BMJ Best Practice's topic on COVID-19: bestpractice.bmj.com/topics/en-gb/3000168 BMJ Learning module on COVID-19 rapid guideline on critical care (NICE): new-learning.bmj.com/course/10065100 BMJ Learning COVID-19 in primary care module: new-learning.bmj.com/course/10065230 Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)00676-0/fulltext Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19: https://www.nejm.org/doi/full/10.1056/NEJMoa2100433 WHO Therapeutics and COVID-19: living guideline: https://app.magicapp.org/#/guideline/nBkO1E/section/LrV7OL Indian Council of Medical Research advice on mucormycosis: https://www.icmr.gov.in/pdf/covid/techdoc/Mucormycosis_ADVISORY_FROM_ICMR_In_COVID19_time.pdf

Persistent depressive disorder is a category that includes various forms of chronic depression in which depressive symptoms are present 'more days than not' over at least a 2-year period (1 year in children and adolescents). David J. Hellerstein, Professor of Clinical Psychiatry, Columbia University Medical Center, gives us a clinical overview of the condition. For more on persistent depressive disorder, visit BMJ Best Practice: bestpractice.bmj.com/topics/en-gb/805 - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner's judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Chronic sinusitis is inflammation of the paranasal sinuses lasting more than 12 weeks. Symptoms include facial pressure, rhinorrhoea, postnasal drainage, congestion, and general malaise. Raj Sindwani, Section Head of Rhinology, Sinus, and Skull Base Surgery, Head and Neck Institute, Cleveland Clinic Foundation, gives us a clinical overview of the condition. For more on chronic sinusitis, visit BMJ Best Practice: bestpractice.bmj.com/topics/en-gb/15 - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner's judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Bulimia nervosa is an eating disorder, characterised by severe preoccupation about weight and body shape. Includes recurrent episodes of binge eating with compensatory mechanisms, such as self-induced vomiting, to prevent weight gain. Debra Safer, Associate Professor, Co-Director of Stanford Eating and Weight Disorders Program, Stanford University School of Medicine, gives us an overview of the condition. For more on bulimia nervosa, see BMJ Best Practice: https://bestpractice.bmj.com/topics/en-gb/441 - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner's judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Giant cell arteritis is a common form of vasculitis in people aged 50 years or older. The extracranial branches of the carotid artery are usually affected. Kenneth J. Warrington, Professor of Medicine, Mayo Clinic College of Medicine, gives us an overview of the condition. For more on giant cell arteritis, visit BMJ Best Practice: bestpractice.bmj.com/topics/en-gb/177 - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner's judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Kieran Walsh, clinical director at BMJ, asks editors from BMJ Learning and BMJ Best Practice to summarise the latest clinical guidance related to covid-19. Emma Scott, section editor, updates us on vaccination for pregnant and breastfeeding women. And Abigail Davis, GP and section editor, covers myocardial infarction and pre-existing respiratory conditions. For more, see: BMJ Best Practice's topic on covid-19: bestpractice.bmj.com/topics/en-gb/3000168 BMJ Learning module on COVID-19 rapid guideline on critical care (NICE): new-learning.bmj.com/course/10065100 BMJ Learning covid-19 in primary care module: new-learning.bmj.com/course/10065230

Kieran Walsh, clinical director at BMJ, asks editors from BMJ Learning and BMJ Best Practice to summarise the latest clinical guidance related to covid-19. Emma Scott, section editor, updates us on vaccination and the risk of blood clots. And Abigail Davis, GP and section editor, covers acute kidney injury, venous thromboembolism prevention, and secondary bacterial pneumonia. For more, see: BMJ Best Practice's topic on covid-19: bestpractice.bmj.com/topics/en-gb/3000168 BMJ Learning module on COVID-19 rapid guideline on critical care (NICE): new-learning.bmj.com/course/10065100 BMJ Learning covid-19 in primary care module: new-learning.bmj.com/course/10065230 EMA: ema.europa.eu/en/news/astrazenecas-covid-19-vaccine-ema-finds-possible-link-very-rare-cases-unusual-blood-clots-low-blood MHRA: gov.uk/government/news/mhra-issues-new-advice-concluding-a-possible-link-between-covid-19-vaccine-astrazeneca-and-extremely-rare-unlikely-to-occur-blood-clots JCVI: gov.uk/government/publications/use-of-the-astrazeneca-covid-19-vaccine-jcvi-statement/jcvi-statement-on-use-of-the-astrazeneca-covid-19-vaccine-7-april-2021 WHO: who.int/news/item/07-04-2021-interim-statement-of-the-covid-19-subcommittee-of-the-who-global-advisory-committee-on-vaccine-safety COVID-19 rapid guideline: managing COVID-19: nice.org.uk/guidance/NG191 - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Depression can describe both a mood and an illness. Major depressive disorder is a clinical syndrome involving mood, neurovegetative functions, cognition, and behaviour. It affects 5% to 10% of patients in the primary care setting. Dean F. MacKinnon, Associate Professor, Psychiatry and Behavioral Sciences, The Johns Hopkins Hospital, Baltimore, gives us an overview of how to diagnose and manage depression in adults. For more on depression in adults, visit BMJ Best Practice: https://bestpractice.bmj.com/topics/en-gb/55 - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Childhood constipation is typically characterised by infrequent bowel evacuations, large stools, and difficult or painful defecation. Symptoms may result from low fibre, poor nutrient, and/or insufficient water intake, which leads to excessive hardening of the stool. This often starts as an acute problem but can progress to faecal impaction and chronic constipation. Claire Zar-Kessler, Instructor in Pediatric Gastroenterology, Massachusetts General Hospital for Children, Boston gives us a clinical overview of the condition. Please always check the licensed indications for medications in your own country. For more on constipation in children, visit BMJ Best Practice: bestpractice.bmj.com/topics/en-gb/784 - The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.