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Natural alternatives for Trump's chronic leg swelling problems; How certain blood and urine tests can help predict osteoporosis; Dark chocolate enhances cognitive function—with lasting effects; caffeinated black coffee reduces risk of death by 14%; NY Times misses the boat again on supplements for immunity; Man dies after being pulled into MRI machine.
Send us a textDid you know that nearly 1 in 10 cancer patients worldwide may develop a potentially deadly blood clot? In this episode, we speak with researcher Jordan Harry, lead author of a landmark systematic review just published in Cancer Epidemiology, that uncovers which solid tumors carry the highest risk of venous thromboembolism (VTE) and where in the world patients are most vulnerable.Jordan walks us through surprising insights from their analysis of over 120 studies:
Just a reminder the legendary Chuck Norris is a whopping 84 years old and yet has MORE energy than most of us — he discovered he could create dramatic changes to his health simply focusing on 3 things that sabotage our body as we age. Watch his method by clicking the link in the description box here: http://ChuckDefense.com/FlyJust a reminder the legendary Chuck Norris is a whopping 84 years old and yet has MORE energy than most of us — he discovered he could create dramatic changes to his health simply focusing on 3 things that sabotage our body as we age. Watch his method by clicking the link in the description box here: http://ChuckDefense.com/Fly http://ChuckDefense.com/FlyToday at 11:11 am CST, on the Flyover Conservatives show we are tackling the most important things going on RIGHT NOW from a Conservative Christian perspective! Today at 11:11 am CST, on the Flyover Conservatives show we are tackling the most important things going on RIGHT NOW from a Conservative Christian perspective! TO WATCH ALL FLYOVER CONTENT: www.theflyoverapp.com TO WATCH ALL FLYOVER CONTENT: www.theflyoverapp.com To Schedule A Time To Talk To Dr. Dr. Kirk Elliott Go To To Schedule A Time To Talk To Dr. Dr. Kirk Elliott Go To ▶ https://flyovergold.com▶ https://flyovergold.comOr Call 720-605-3900 Or Call 720-605-3900 ► Receive your FREE 52 Date Night Ideas Playbook to make date night more exciting, go to www.prosperousmarriage.com► Receive your FREE 52 Date Night Ideas Playbook to make date night more exciting, go to www.prosperousmarriage.comwww.prosperousmarriage.comDr. Bryan Ardis:Dr. Bryan Ardis:WEBSITE: https://thSend us a message... we can't reply, but we read them all!Support the show► ReAwaken America- text the word FLYOVER to 918-851-0102 (Message and data rates may apply. Terms/privacy: 40509-info.com) ► Kirk Elliott PHD - http://FlyoverGold.com ► My Pillow - https://MyPillow.com/Flyover ► ALL LINKS: https://sociatap.com/FlyoverConservatives
Embalmers across the U.S. are reporting an alarming rise in unusual, persistent blood clots found in corpses since the rollout of the COVID-19 vaccines. In this eye-opening interview, researcher Thomas Haviland shares findings from his national survey, highlighting what embalmers say was rare or nonexistent prior to 2021. Plus segments on Israel and zonist turn on Piers Morgan and Diddy's acquitted of sex trafficing and rico charges. Featuring Thomas Haviland, Kurt Metzger, and Stef Zamorano
This episode was inspired by this article by the wonderful Tara from Coogee Run Club - https://www.bodyandsoul.com.au/health/health-news/marathon-running-deep-vein-thrombosis-risk-blood-clot/news-story/7b1358593ed07953ec08b7f5d9c0f105 Thanks for listening!!@strongerstride
6/23/2025 PODCAST Episodes #2018 - #2020 GUESTS: Suzy Kelly, Will Hild, Tom Haviland, Dr. James Thorp, Sen. Doug Mastriano, Sean Connaughton, Rabbi Yaakov Menken + YOUR CALLS! at 1-888-480-JOHN (5646) and GETTR Live! @jfradioshow #GodzillaOfTruth #TruckingTheTruth Want more of today's show? Episode #2018 DEI's Catastrophe; Covid's Blood Clots Hit Danger Zone Episode #2019 DEMS Hate America, Root For Military Failure in Iran Episode #2020 VHHA Urges Senate to Use House Plan for Medicaid To Rural Hospitals https://johnfredericksradio.libsyn.com/
In this episode, we welcome Dr. Jewel Kling, an expert in women's health and menopause. Dr. Kling is a professor of medicine, chair of the Division of Women's Health at the Mayo Clinic in Scottsdale, Arizona. She is also the director of the Women's Health Center and dean of the Mayo Clinic Arizona Campus. With a background in public health and internal medicine, Dr. Kling has become a recognized leader in the fields of menopause, sexual health, and LGBT care education. She speaks nationally on menopause and hormone therapy and has published extensively on the subject.Dr. Kling joins us to dive into the topic of perimenopause, shedding light on common misconceptions and discussing the best approaches to treatment. In particular, she offers her insights on the pros and cons of starting hormone therapy during perimenopause and how to address contraception during this transitional period.Key discussion points: Perimenopause and Hormone Therapy Managing Symptoms Contraception Considerations Individualized CareThroughout the episode, Dr. Kling provides evidence-based insights and reassures women that effective treatments are available, especially for those suffering from persistent symptoms beyond the typical transition period.As an advocate for women's health, Dr. Kling is also involved in advanced hormone therapy training through the International Society for the Study of Women's Sexual Health (ISWHISH), where she and Dr. Sarah Cigna offer a comprehensive course for healthcare professionals. See below!Resources Mentioned: Advanced Hormone Therapy Course - A year-long virtual course for healthcare professionals, covering a range of topics, including hormone therapy and its effects on sexual functioning throughout different life stages, including pregnancy, lactation, and menopause. The Menopause Society - A resource for menopausal health and guidance on finding certified menopause practitioners.If you're experiencing perimenopausal symptoms or seeking guidance on hormone therapy, this episode offers invaluable knowledge and practical advice for navigating this stage of life with confidence.For more information on the Advanced Hormone Therapy Course and other resources, visit ISWHISH.
Aubrey converses with Dr Matome Kganakga, General Practitioner, about what blood clotting is and the danger to poses to our health if not checked and treated. The Aubrey Masango Show is presented by late night radio broadcaster Aubrey Masango. Aubrey hosts in-depth interviews on controversial political issues and chats to experts offering life advice and guidance in areas of psychology, personal finance and more. All Aubrey’s interviews are podcasted for you to catch-up and listen. Thank you for listening to this podcast from The Aubrey Masango Show. Listen live on weekdays between 20:00 and 24:00 (SA Time) to The Aubrey Masango Show broadcast on 702 https://buff.ly/gk3y0Kj and on CapeTalk between 20:00 and 21:00 (SA Time) https://buff.ly/NnFM3Nk Find out more about the show here https://buff.ly/lzyKCv0 and get all the catch-up podcasts https://buff.ly/rT6znsn Subscribe to the 702 and CapeTalk Daily and Weekly Newsletters https://buff.ly/v5mfet Follow us on social media: 702 on Facebook: https://www.facebook.com/TalkRadio702 702 on TikTok: https://www.tiktok.com/@talkradio702 702 on Instagram: https://www.instagram.com/talkradio702/ 702 on X: https://x.com/Radio702 702 on YouTube: https://www.youtube.com/@radio702 CapeTalk on Facebook: https://www.facebook.com/CapeTalk CapeTalk on TikTok: https://www.tiktok.com/@capetalk CapeTalk on Instagram: https://www.instagram.com/ CapeTalk on X: https://x.com/CapeTalk CapeTalk on YouTube: https://www.youtube.com/@CapeTalk567 See omnystudio.com/listener for privacy information.
Essential Vitamins to Naturally Dissolve Blood Clots could be the life-saving knowledge you didn't knowyou needed. In this powerful podcast, we uncover natural vitamins scientifically linked to improving circulation and breaking down dangerous clots—without synthetic drugs or side effects. https://lovewithsex.me/?p=26789 Learn how nutrients like Vitamin E, K2, and others play a key role in blood health, and what foods and supplements can help support a healthier cardiovascular system. Whether you're managing clot risks, on blood thinners, or just aiming to boost circulation, these natural solutions are a game-changer. Subscribe now for more health wisdom, and discover how to take control of your wellness—naturally! Essential Vitamins to Naturally Dissolve Blood Clots, vitamins for blood clots, natural blood clot remedies, dissolve clots naturally, vitamins for circulation, prevent blood clots, heart health supplements, vitamin E for blood health,vitamin K2 benefits, blood clot home remedies, holistic health for blood, natural circulation boosters, improve blood flow naturally, healthy blood tips, anti-clotting vitamins, how to dissolve blood clots, avoid blood thinners naturally, cardiovascular health hacks, foods that prevent clots, supplement for circulation, blood clot solutions, healthy veins and arteries, healing naturally, wellness and blood health, vitamin guide for heart health, dissolve at home, natural anticoagulants, herbs and vitamins for blood clots, heart-friendly vitamins, holistic blood clot support, vitamins that help blood flow, safe remedies for clots, prevent DVT naturally, vitamins for vein health,circulation boost naturally, #DissolveBloodClots, #NaturalHealthTips, #EssentialVitamins, #BloodClotPrevention, #CirculationSupport, #VitaminEHealth, #HealthyHeartTips, #NaturalRemedies, #HolisticHealing, #BloodHealth,#MagnesiumBreakthrough, #BloodClotHealth, #NaturalHealing, #VitaminBenefits,#HealthTips, #WellnessJourney, #HolisticHealth, #HealthyLiving, #NutritionalSupport, #DoctorApproved, #WellnessWarrior, #VitaminsForLife,#ClotDissolving, #HealthAwareness, #PreventiveCare, #HealthyChoices, #SelfCareTips, #EmpowerYourHealth, #MindfulNutrition, #StayInformed,
Nutrition Nugget! Bite-size bonus episodes offer tips, tricks and approachable science. This week, Jenn is talking about Rutin, a powerful plant pigment that could transform your health with its antioxidant punch. It is found in foods like apples and buckwheat, so it teams up with vitamin C for surprising benefits. How might this little-known nutrient boost your brain, heart, blood pressure and more? What's one food you already eat that could be packing this hidden benefit? Tune in to find out! Like what you're hearing? Be sure to check out the full-length episodes of new releases every Wednesday. Have an idea for a nutrition nugget? Submit it here: https://asaladwithasideoffries.com/index.php/contact/ RESOURCES:Become A Member of Salad with a Side of FriesJenn's Free Menu PlanA Salad With a Side of FriesA Salad With A Side Of Fries MerchA Salad With a Side of Fries InstagramNutrition Nugget: Quercetin
COVID, CANCER, BLOOD CLOTS & EVERYTHING IN BETWEEN In today's Take Your Power Back Show conversation, COVID, CANCER, BLOOD CLOTS & EVERYTHING IN BETWEEN, Kim Yeater speaks with embalming expert Richard Hirschman, who was highlighted in the 2022 documentary, DIED SUDDENLY, for his evidence regarding the change in the blood and fibrous material discovered during the embalming process. Also joining us is Thomas Haviland, a 20 Year Air Force Major-Data Analyst Specialist working closely with the embalmers and John Richardson Operation World Without Cancer and Richardson Nutritional Center aiming to contribute to a world where cancer is better understood and ultimately eradicated. These warriors are questioning the Medical Industrial Complex and helping people to TAKE BACK THEIR HEALTH! We are in for a great show today!! Kim Yeater-Take Your Power Back Showhttps://KimYeater.com https://www.TakeYourPowerBackShow.com Rumble: https://rumble.com/c/TakeYourPowerBackShow Live Stream: https://rumble.com/TakeYourPowerBackShow/livePodcast Platforms: https://takeyourpowerbackshow.buzzsprout.com Patriot TV: https://patriot.tv/take-your-power-back/ X @realkimyeaterFB kimberlyyeater & TakeyourpowerbackshowIG Takeyourpowerback_kimyeaterT takeyourpowerbackshowTake Our Border Backhttps://TakeOurBorderBack. Com https://rumble.com/c/TakeOurBorderBack Live Stream: https://rumble.com/TakeOurBorderBack/live X @TobbconvoymainX @TobbconvoycaliforniaX @TobbconvoyarizonaX @TobbconvoytexasSend us a textSupport the show
Just a reminder the legendary Chuck Norris is a whopping 84 years old and yet has MORE energy than most of us — he discovered he could create dramatic changes to his health simply focusing on 3 things that sabotage our body as we age. Watch his method by clicking the link in the description box here: https://chuckdefense.com/flyJust a reminder the legendary Chuck Norris is a whopping 84 years old and yet has MORE energy than most of us — he discovered he could create dramatic changes to his health simply focusing on 3 things that sabotage our body as we age. Watch his method by clicking the link in the description box here: https://chuckdefense.com/flyhttps://chuckdefense.com/flyToday at 11:11 am CST, on the Flyover Conservatives show we are tackling the most important things going on RIGHT NOW from a Conservative Christian perspective! Today at 11:11 am CST, on the Flyover Conservatives show we are tackling the most important things going on RIGHT NOW from a Conservative Christian perspective! TO WATCH ALL FLYOVER CONSERVATIVES SHOWS - https://flyover.live/show/flyoverTO WATCH ALL FLYOVER CONSERVATIVES SHOWS - https://flyover.live/show/flyoverTO WATCH ALL FLYOVER CONTENT: www.flyover.liveTO WATCH ALL FLYOVER CONTENT: www.flyover.liveTo Schedule A Time To Talk To Dr. Dr. Kirk Elliott Go To To Schedule A Time To Talk To Dr. Dr. Kirk Elliott Go To ▶ https://flyovergold.com▶ https://flyovergold.comOr Call 720-605-3900 Or Call 720-605-3900 ► Receive your FREE 52 Date Night Ideas Playbook to make date night more exciting, go to www.prosperousmarriage.com► Receive your FREE 52 Date Night Ideas Playbook to make date night more exciting, go to www.prosperousmarriage.comwww.prosperousmarriage.comGET YOUSend us a message... we can't reply, but we read them all!Support the show► ReAwaken America- text the word FLYOVER to 918-851-0102 (Message and data rates may apply. Terms/privacy: 40509-info.com) ► Kirk Elliott PHD - http://FlyoverGold.com ► My Pillow - https://MyPillow.com/Flyover ► ALL LINKS: https://sociatap.com/FlyoverConservatives
Just a reminder the legendary Chuck Norris is a whopping 84 years old and yet has MORE energy than most of us — he discovered he could create dramatic changes to his health simply focusing on 3 things that sabotage our body as we age. Watch his method by clicking the link in the description box here: http://ChuckDefense.com/FlyJust a reminder the legendary Chuck Norris is a whopping 84 years old and yet has MORE energy than most of us — he discovered he could create dramatic changes to his health simply focusing on 3 things that sabotage our body as we age. Watch his method by clicking the link in the description box here: http://ChuckDefense.com/Flyhttp://ChuckDefense.com/FlyToday at 11:11 am CST, on the Flyover Conservatives show we are tackling the most important things going on RIGHT NOW from a Conservative Christian perspective! Today at 11:11 am CST, on the Flyover Conservatives show we are tackling the most important things going on RIGHT NOW from a Conservative Christian perspective! TO WATCH ALL FLYOVER CONSERVATIVES SHOWS - https://flyover.live/show/flyoverTO WATCH ALL FLYOVER CONSERVATIVES SHOWS - https://flyover.live/show/flyoverTO WATCH ALL FLYOVER CONTENT: www.flyover.liveTO WATCH ALL FLYOVER CONTENT: www.flyover.liveTo Schedule A Time To Talk To Dr. Dr. Kirk Elliott Go To To Schedule A Time To Talk To Dr. Dr. Kirk Elliott Go To ▶ https://flyovergold.com▶ https://flyovergold.comOr Call 720-605-3900 Or Call 720-605-3900 Dr. Bryan Ardis:Dr. Bryan Ardis:WEBSITE: https://thedrardisshow.com WEBSITE: https://thedrardisshow.comhttps://thedrardisshow.com TELEGRAM: Send us a message... we can't reply, but we read them all!Support the show► ReAwaken America- text the word FLYOVER to 918-851-0102 (Message and data rates may apply. Terms/privacy: 40509-info.com) ► Kirk Elliott PHD - http://FlyoverGold.com ► My Pillow - https://MyPillow.com/Flyover ► ALL LINKS: https://sociatap.com/FlyoverConservatives
You've probably heard of enzymes for digestive support, but how about for inflammation, pain, and cardiovascular health? On this episode of of Vitality Radio Jared welcomes back Mike Kramarchek to discuss systemic enzymes, focusing on their benefits, differences from digestive enzymes, and their role in pain and inflammation management. The conversation explores how aging affects enzyme production, the benefits of enzyme supplementation, and the unique features of the Fibrenza formula. They dig a little deeper into nattokinase and its role in cardiovascular health including the impact of fibrin on blood health.Products:Fibrenza Systemic EnzymesAdditional Information:#407: Deep Dive on Nattokinase: A Special Enzyme with Cardiovascular Benefits and More with Julia Craven#301: Systemic Enzymes for Mucus, Candida, Immune Support, Heart Health and more. Also a Brand New Magnesium! Guest, Julia CravenVisit the podcast website here: VitalityRadio.comYou can follow @vitalitynutritionbountiful and @vitalityradio on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.
Today at 11:11 am CST, on the Flyover Conservatives show we are tackling the most important things going on RIGHT NOW from a Conservative Christian perspective! Today at 11:11 am CST, on the Flyover Conservatives show we are tackling the most important things going on RIGHT NOW from a Conservative Christian perspective! TO WATCH ALL FLYOVER CONSERVATIVES SHOWS - https://flyover.live/show/flyoverTO WATCH ALL FLYOVER CONSERVATIVES SHOWS - https://flyover.live/show/flyoverTO WATCH ALL FLYOVER CONTENT: www.flyover.liveTO WATCH ALL FLYOVER CONTENT: www.flyover.liveTo Schedule A Time To Talk To Dr. Dr. Kirk Elliott Go To To Schedule A Time To Talk To Dr. Dr. Kirk Elliott Go To ▶ https://flyovergold.com▶ https://flyovergold.comOr Call 720-605-3900 Or Call 720-605-3900 Dr. Bryan Ardis:Dr. Bryan Ardis:WEBSITE: https://thedrardisshow.com WEBSITE: https://thedrardisshow.comhttps://thedrardisshow.com TELEGRAM: https://t.me/thedrardisshowTELEGRAM: https://t.me/thedrardisshowhttps://t.me/thedrardisshowEVENT: https://healingfortheages.com/ EVENT: https://healingfortheages.com/https://healingfortheages.com/ BOOK: Send us a message... we can't reply, but we read them all!Support the show► ReAwaken America- text the word FLYOVER to 918-851-0102 (Message and data rates may apply. Terms/privacy: 40509-info.com) ► Kirk Elliott PHD - http://FlyoverGold.com ► My Pillow - https://MyPillow.com/Flyover ► ALL LINKS: https://sociatap.com/FlyoverConservatives
Welcome back to our weekend Cabral HouseCall shows! This is where we answer our community's wellness, weight loss, and anti-aging questions to help people get back on track! Check out today's questions: Michael: Hi Dr. Cabral! Thank you for the great work that you do! I'm hoping you can speak to the risk and benefits of regular blood and plasma donations. At what iron levels would you likely recommend someone give blood, if at all? Also, what is the difference between a plasma donation and plasmapheresis? Can you get similar benefits from regular plasma donations as you can from plasmapheresis? Thank you! Anonymous: Hi Dr Cabral, In my teenage years, I was quite often prescribed anitbiotics to combat cystic acne. I was mostly prescribed tetracycline, and a few others that I cant remember. I was on them for quite a while as I just did not respond well to acutane. Im a male and 40 years old now and I do have quite a bit of gi issues. My first GI doctor diagnosed me with dispepsia, though I wasnt tested for that so i dont know how he arrived at that conclusion. My 2nd GI Dr. ran a stool test that came back normal. Is it possible for such antibiotic during teenage years to lead to GI issues? I know nothing is certain without testing but just curious if its even a possibility considering it was so long ago and Ive largely avoided them since my 20's. Thanks Elizabeth: Hi, Dr. Cabral. On a previous show, you mentioned a red light therapy device and that devices get better every couple of years. I noticed the one on your resource pages is at least a couple years old, so I'm not sure it's still as effective as some of the newer ones. When looking for red light therapy caps for hair growth, what numbers (levels) and how many red lights should be the minimum in a red light therapy cap? Some can get quite pricey and I'm looking for something that is cost effective. Thank you so much! I look forward to hearing back! Marie-Eve: Hi Dr. Cabral, I am an IHP level 1 and soon 2 student. I have been using the X39 patch for the past 3 months and very much respect your knowledge about all things health. You have experienced, seen, read, done so many things in the health and wellness World and I take your opinion very seriously. You have mentioned a few times in your podcast that you have not seen any clinical studies about X39 and wanted to share these 2 with you. I was pleased to know about an affordable way to activate stem cells and copper peptides but I don't understand the deeper langage when it comes to researchers sometimes. I agree that blind testing is not enough and we need actual clinical studies to prove its benefits. I would love to hear your thoughts on those researches I found through my portal. Ian: Hi Dr. Cabral, I hope this message finds you well. One of my favorite basketball players, Victor Wembanyama (Wemby), was diagnosed with a deep vein thrombosis in his right shoulder, which is his shooting shoulder. He's 7 feet, 4 inches and 21 years old. From my perspective, it's very likely that taller people develop cardiovascular issues, and health issues in general, more often than shorter individuals... but Wemby is quite young and perhaps we might not expect cardiovascular issues at this age. I'd like to break down what may lead to blood clotting, especially in tall humans. What might the body be responding to with aggregations of blood in its attempt to reach its balanced state? Lastly, what modalities could be taken to mitigate blood clots in general, and athletes in particular? Thank you for tuning into today's Cabral HouseCall and be sure to check back tomorrow where we answer more of our community's questions! - - - Show Notes and Resources: StephenCabral.com/3347 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!
What's Next for Ja Morant After Taylor Jenkins' Firing?: Coley and Trill dive headfirst into Third Times the Charm! The boys kick things off by discussing why they believe college basketball needs an age limit after watching so much March Madness. After some college hoops talk, the conversation shifts to the Yankees' controversial new torpedo bats. Are these new bats as good as people think they are? Or are the Brewers simply just that bad? From there, Coley & Trill discuss why the Memphis Grizzles fired Taylor Jenkins with nine games left of the NBA regular season and question whether the franchise wants to move on from Ja Morant. All this and more on this episode of Third Times the Charm! (0:00) RIP Young Scooter (7:39) How Is Coley's Son So Damn Tiny?!? (12:18) It's Time to Put An Age Limit on CBB (22:59) Society Loves Tall Guys (24:48) UD Ad Read (25:34) Brewers Pitchers Just Suck (29:07) Are Torpedo Bats Good for Baseball? (33:59) Time to Blow Up the Braves? (36:44) Robert D. Manfred Jr. (40:24) How Powerful is J.D. Power? (50:45) Kelly Blue Book Holds Too Much Power (53:35) Airport Magazines (58:54) Coley Learns the Origin Story of Michael Rubin (1:04:41) Shop SKIMS (1:09:00) Browns Admit Deshaun Watson Mistake (1:10:39) Would the Titans Trade the No. 1 Pick? (1:20:19) Damian Lillard's Blood Clots (1:22:00) Is Gannis Done With the Bucks? (1:23:26) Lakers ARE NOT Clicking (1:25:00) Grizzlies Fire Taylor Jenkins (1:30:46) Are the Grizzlies Trying to Trade Ja Morant? (1:34:51) Domantas Sabonis Doesn't Fit Really Anywhere… (1:36:27) Will the Spurs Commit to De'Aaron Fox? (1:38:08) Celtics Can't Make Any Trades (1:40:00) The Bucks are SO COOKED (1:41:00) Sabonis for Joel Embiid?! (1:46:33) Bradley Beal is VERY Tradable (1:49:05) Isaiah Stewart Should Fight Every Team (1:51:08) Coley Believes the Thunder Will Walk Through the West (1:53:35) Rockets Shouldn't Be Getting Celtics Comparisons (1:54:56) Which Team Would Want Jenkins? (2:03:27) LeBron on the Lakers Next Year is No Guarantee (2:14:00) LeBron James: The Standup Comedian (2:21:45) CBS Actors are Rich (2:28:31) Danny Trejo is on Bar Rescue Coley Mick and Trill Withers are back (again), with Third Time's The Charm! Their newest show, presented by Underdog Fantasy, features the two like they never left. Coley and Trill will cover sports and just about everything else. Sign up for Underdog Fantasy HERE with promo code CHARM and get up to 50% first deposit bonus up to $1,000: https://play.underdogfantasy.com/p-third-timesthe-charm Subscribe to the Podcast
Ferrall talks about Russ Wilson & Stefon Diggs Signings, Dame Lillard's Blood Clots, & Everything Going on in Sports.
Today at 11:11 am CST, on the Flyover Conservatives show we are tackling the most important things going on RIGHT NOW from a Conservative Christian perspective! Today at 11:11 am CST, on the Flyover Conservatives show we are tackling the most important things going on RIGHT NOW from a Conservative Christian perspective! TO WATCH ALL FLYOVER CONSERVATIVES SHOWS - https://flyover.live/show/flyoverTO WATCH ALL FLYOVER CONSERVATIVES SHOWS - https://flyover.live/show/flyoverTO WATCH ALL FLYOVER CONTENT: www.flyover.liveTO WATCH ALL FLYOVER CONTENT: www.flyover.liveTo Schedule A Time To Talk To Dr. Dr. Kirk Elliott Go To To Schedule A Time To Talk To Dr. Dr. Kirk Elliott Go To ▶ https://flyovergold.com▶ https://flyovergold.comOr Call 720-605-3900 Or Call 720-605-3900 Dr. Bryan Ardis:Dr. Bryan Ardis:WEBSITE: https://thedrardisshow.com WEBSITE: https://thedrardisshow.comhttps://thedrardisshow.com TELEGRAM: https://t.me/thedrardisshowTELEGRAM: https://t.me/thedrardisshowhttps://t.me/thedrardisshowEVENT: https://healingfortheages.com/ EVENT: https://healingfortheages.com/https://healingfortheages.com/ BOOK: Send us a message... we can't reply, but we read them all!Support the show► ReAwaken America- text the word FLYOVER to 918-851-0102 (Message and data rates may apply. Terms/privacy: 40509-info.com) ► Kirk Elliott PHD - http://FlyoverGold.com ► My Pillow - https://MyPillow.com/Flyover ► ALL LINKS: https://sociatap.com/FlyoverConservatives
Al & Jerry: Canada got the best of us, a pitcher gets drilled in the head, Juan Soto gifts Brett Baty a car and what's the deal with blood clots? To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices
Venous Thromboembolism (VTE) is a condition where blood clots form in a blood vessel. As serious as heart attacks and strokes, VTE is the most common cause of preventable death in hospitalized patients. Interventional Radiologist Scott Perrin, MD, discusses the dangers of the disease and what can be done to treat deep vein thrombosis (DVT) and pulmonary embolism (PE).You can also watch the video recording on our Vimeo channel here.For more health tips & news you can use from experts you trust, sign up for Sarasota Memorial's monthly digital newsletter, Healthe-Matters.
Join me for an important discussion with Tom Haviland. To learn more about investing in gold & silver visit - http://goldwithseth.com, or call 626-654-1906 For high quality storable foods and seeds, visit http://heavensharvest.com and use promo code SETH to save 15% on your order.See omnystudio.com/listener for privacy information.
What dosage of Nicotinamide Riboside is optimal in increasing mitochondrial biogenesis?I've been treated for SIBO in the past but haven't yet tried rifaximin. Do you recommend it?Is the choline in eggs causing thousands of people to suddenly form blood clots?Is the EBCT still the most accurate, least-radiation-exposure test for coronary calcification?How many milligrams of SAMe do you recommend for depression?
Carpenter January! Carptenry! This week, we WRESTLE Carpenter's 1988 They Live, starring Rowdy Roddy Piper and Keith David. This classic is known for its one-liners, 6.5 minute fight scene, and iconic messages. Ween covers Blood Clots for Tubi or Not Tubi this week! Up Next: The Fog What We're Watching: Last Week Tonight with John Oliver - WWE Iron Claw Where to Find us: Instagram Threads Facebook Youtube TikTok Letterboxd boozeboobsandbloodpodcast@gmail.com boozeboobsandbloodpodcast.com bluesky: @b3podcast.bsky.social
This week we discuss blood clots A blood clot is a clump of blood that has changed from a liquid to a gel-like or semisolid state. Clotting is a necessary process that can help prevent excessive blood loss when you have a cut, for example. Thrombosis is when a blood clot forms and reduces blood flow. There are two types: Arterial thrombosis occurs when a blood clot forms in an artery. Venous thrombosis occurs when a blood clot forms in a vein. When a clot forms inside one of your veins, it may dissolve on its own. However, sometimes a clot doesn't dissolve on its own, or part of it breaks off and travels elsewhere in your circulatory system. When this happens, the blood clot may get stuck elsewhere and restrict blood flow, known as embolism. These situations can be very dangerous and even life threatening. According to the Centers for Disease Control and Prevention (CDC), 1 in 2 people don't experience any symptoms when they have a deep venous blood clot. When symptoms do appear, it's important to get immediate medical attention. Medical emergency A blood clot may be a medical emergency and life threatening if left untreated. Call 911 or go to the nearest emergency room immediately if you or someone you're with experiences symptoms of a serious blood clot, such as: sudden shortness of breath chest pressure difficulty breathing, seeing, or speaking Call a doctor or seek medical attention if you experience throbbing, swelling, and tenderness in one body part.
In this conversation, Dr. Sam Sigoloff and Tom Haviland discuss alarming findings from a series of surveys conducted among embalmers regarding the presence of unusual blood clots in corpses. The surveys reveal a significant increase in the observation of white fibrous clots and microclotting since the rollout of COVID-19 vaccines. Haviland shares insights from the latest survey conducted in 2024, highlighting the psychological barriers embalmers face in discussing these findings publicly. The conversation also touches on the implications of these observations for public health and the responsibilities of professionals in the funeral industry. In this conversation, Dr. Sam Sigoloff and USAF Major Tom Haviland discuss the ethical responsibilities of embalmers in reporting unusual phenomena observed in corpses, particularly related to clotting issues post-COVID vaccination. They explore the political divides surrounding vaccine perspectives, share personal stories regarding vaccine status, and highlight the alarming increase in clotting phenomena observed by embalmers. The discussion also touches on the limitations of autopsies, financial incentives affecting death reporting, and concerns over the safety of mRNA technology. The conversation concludes with a focus on the impact of vaccines on women's health and the need for more transparency and investigation in the medical community.lf you like my t-shirt please get one here: XL https://www.ebay.com/itm/166498979030?mkcid=16&mkevt=1&mkrid=711-127632-2357-0&ssspo=p4ex0znwsqu&sssrc=4429486&ssuid=p4ex0znwsqu&var=&widget_ver=artemis&media=COPYLarge https://www.ebay.com/itm/166498976051?mkcid=16&mkevt=1&mkrid=711-127632-2357-0&ssspo=p4ex0znwsqu&sssrc=4429486&ssuid=p4ex0znwsqu&var=&widget_ver=artemis&media=COPYMedium https://www.ebay.com/itm/166498969796?mkcid=16&mkevt=1&mkrid=711-127632-2357-0&ssspo=p4ex0znwsqu&sssrc=4429486&ssuid=p4ex0znwsqu&var=&widget_ver=artemis&media=COPYSmall https://www.ebay.com/itm/166498972939?mkcid=16&mkevt=1&mkrid=711-127632-2357-0&ssspo=p4ex0znwsqu&sssrc=4429486&ssuid=p4ex0znwsqu&var=&widget_ver=artemis&media=COPYIf you would like to purchase better than grass fed and grass finished beef that will never get mRNA injections, never get growth hormones and never get antibiotics check out mycleanbeef.com/afterhoursAs always please like, share and follow. Please check out my Patreon account (https://www.patreon.com/Afterhourswithdrsigoloff). This is mostly to help with the legal fees. Please consider contributing but if you are unable to donate money please give prayers.truthforhealth.org for COVID illness and long haulers syndrome treatment protocols. If you have a vaccine injury (from any vaccine or have any injury that you think may have any relation to any vaccine) please report in their civilian equivalent to VAERS.Patreon: https://www.patreon.com/Afterhourswithdrsigoloff Email: afterhours@1791.com Instagram: @afterhourswithdrsigoloff Clouthub: @DrSigoloff TruthSocial: @DrSigoloff Rumble: https://rumble.com/c/AfterHoursWithDrSigoloff Youtube: https://www.youtube.com/channel/UCQ_ng3WYVhnctCYq6Rom07g Givesendgo: https://www.givesendgo.com/G37EN
Guest Renee Zhao works at the cutting-edge of robotic surgery – literally. Emboldened by advances in 3D-printing and miniaturization, she builds “millibots,” magnet-controlled, millimeter-scale soft robots that navigate the bloodstream to remove blood clots and treat brain aneurysms. While the millibot's promise is clear, much work remains before the devices are commonplace. Revolutionizing health care with surgical robots will require a delicate balance of design, buildability, and functionality, Zhao tells host Russ Altman on this episode of Stanford Engineering's The Future of Everything podcast.Have a question for Russ? Send it our way in writing or via voice memo, and it might be featured on an upcoming episode. Please introduce yourself, let us know where you're listening from, and share your quest. You can send questions to thefutureofeverything@stanford.edu.Episode Reference Links:Stanford Profile: Renee ZhaoConnect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>> Twitter/X / Instagram / LinkedIn / FacebookChapters:(00:00:00) IntroductionRuss Altman introduces guest Renee Zhao, a professor of mechanical engineering at Stanford University.(00:03:34) Robotic Surgery and HealthcareRenee's inspiration for soft robotics and its potential in healthcare applications.(00:05:49) Current Status of Robotic SurgeryCurrent robotic surgery technologies and the push for more advanced solutions.(00:09:32) Nature-Inspired Soft RoboticsHow soft robotic systems are ideal for working within delicate human tissues.(00:11:41) Millirobotic SystemsRecently developed millimeter-sized robots that swim and navigate blood vessels.(00:14:46) Millirobot ControlThe role of magnetic fields and imaging technology for robot navigation.(00:17:18) Treating Blood Clots and AneurysmsThe multifunctional abilities of robots to deliver drugs and treat blood clots.(00:19:46) Doctor's Reaction to New TechnologyExcitement for the new robotic advancements amongst the need for better tools.(00:21:04) Trends in Robot Size and FunctionalityThe design challenges for creating small yet functional robots.(00:25:52) AI and Machine Learning in Robotic DesignAI's role in optimizing robot design for specific patients.(00:28:59) Why Millimeter-Scale RobotsWhy millirobots strike the right balance for performance and functionality.(00:32:34) Conclusion Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook
In this episode of the Heart to Heart podcast, Dr. Trey Baucum delves into the critical topic of blood clots and their impact on heart health. He explains the risks associated with blood clots, how they form, and the warning signs to watch for. Dr. Baucum also shares expert advice on prevention, treatment options, and steps you can take to protect your cardiovascular health. Tune in to learn more about managing your risks and keeping your heart in top shape. The post Blood Clots first appeared on Advanced Cardiovascular Specialists.
In this episode, we dive into some trending and headline-grabbing topics, including: • Gal Gadot's shocking revelation about surviving a massive blood clot during her pregnancy. • Washington Commanders safety Jeremy Reaves proposing to his girlfriend after clinching a playoff spot for the first time since 2020. • Commanders' playoff success as Jayden Daniels shines again. • Remembering the 39th U.S. President, Jimmy Carter, who passed away at age 100, as tributes pour in honoring his remarkable legacy. Next, we tackle cigar industry news with a look at Warped's New Day, which has reached a dozen retailers. Then, we share a wild and dangerous Florida story about an Osceola County pizza delivery driver charged with murder following a dispute over a tip. And, of course, we wrap up with our weekly shoutouts: • Shop of the Week: Riverside Cigars • Listener of the Week: William Cooper Tune in for all this and more on Episode 368!
In this episode, we dive into some trending and headline-grabbing topics, including: • Gal Gadot's shocking revelation about surviving a massive blood clot during her pregnancy. • Washington Commanders safety Jeremy Reaves proposing to his girlfriend after clinching a playoff spot for the first time since 2020. • Commanders' playoff success as Jayden Daniels shines again. • Remembering the 39th U.S. President, Jimmy Carter, who passed away at age 100, as tributes pour in honoring his remarkable legacy. Next, we tackle cigar industry news with a look at Warped's New Day, which has reached a dozen retailers. Then, we share a wild and dangerous Florida story about an Osceola County pizza delivery driver charged with murder following a dispute over a tip. And, of course, we wrap up with our weekly shoutouts: • Shop of the Week: Riverside Cigars • Listener of the Week: William Cooper Tune in for all this and more on Episode 368!
Dr Tony Wan shares the results of a study that examined the effectiveness of an anticoagulation stewardship program (ACSP) in improving adherence to venous thromboembolism (VTE) prophylaxis guidelines and reducing costs at a Canadian teaching hospital. Here what he has to say about the results and the process of setting up the study in his hospital.Tony Wan, Stephanie J. Garland, Chipman Taylor Drury, Justin Lambert, Joshua Yoon, Melissa Chan, Anticoagulation stewardship: Improving adherence to clinical guidelines and reducing overuse of venous thromboembolism prophylaxis in hospitalized medical patients, Thrombosis Research, Volume 239, 2024, https://www.sciencedirect.com/science/article/pii/S0049384824001622 Donate to Thrombosis Canada: https://thrombosiscanada.ca/donateSupport the showhttps://thrombosiscanada.caTake a look at our healthcare professional and patient resources, videos and publications on thrombosis from the expert members of Thrombosis Canada
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Did u hear # 46: Drones, Earthquakes,Blood clot drugs, Cooking oil and more Challenges of Faith Radio Program is a ministry program designed to "Uplift" People of Faith. Uplifting from the perspective of providing Biblical, Cultural, Educational, Relational, and Spiritual information. COFRP was ranked #4 Jan 2-Mar 8, 24 #5 Mar 8-May 10 among the top 100 Christian podcast on Feedspot.com and has also made (12/1824) the following top listener chart on Goodpods:#22 in the Top 100 Author All time chart Challenges of Faith Radio is now on Spreaker, TalkShoe and iHeart Radio, CastBox, Goodpods, Amazon Music, Deever,Podbean,Spotify, Apple, Youtube (like and subscribe) and many more.
Tonight at 8:30 pm CST, on the Flyover Conservatives show we are tackling the most important things going on RIGHT NOW from a Conservative Christian perspective! Tonight at 8:30 pm CST, on the Flyover Conservatives show we are tackling the most important things going on RIGHT NOW from a Conservative Christian perspective! TO WATCH ALL FLYOVER CONSERVATIVES SHOWS - https://flyover.live/show/flyoverTO WATCH ALL FLYOVER CONSERVATIVES SHOWS - https://flyover.live/show/flyoverTO WATCH ALL FLYOVER CONTENT: www.flyover.liveTO WATCH ALL FLYOVER CONTENT: www.flyover.liveDr. Bryan Ardis:Dr. Bryan Ardis:WEBSITE: https://thedrardisshow.com WEBSITE: https://thedrardisshow.comhttps://thedrardisshow.com TELEGRAM: https://t.me/thedrardisshowTELEGRAM: https://t.me/thedrardisshowhttps://t.me/thedrardisshowEVENT: https://healingfortheages.com/ EVENT: https://healingfortheages.com/https://healingfortheages.com/ BOOK: https://thedrardisshow.com/beyond-c-19-lies-book/#video BOOK: Send us a message... we can't reply, but we read them all!Support the show► ReAwaken America- text the word FLYOVER to 918-851-0102 (Message and data rates may apply. Terms/privacy: 40509-info.com) ► Kirk Elliott PHD - http://FlyoverGold.com ► My Pillow - https://MyPillow.com/Flyover ► ALL LINKS: https://sociatap.com/FlyoverConservatives
Tonight at 8:30 pm CST, on the Flyover Conservatives show we are tackling the most important things going on RIGHT NOW from a Conservative Christian perspective! Tonight at 8:30 pm CST, on the Flyover Conservatives show we are tackling the most important things going on RIGHT NOW from a Conservative Christian perspective! TO WATCH ALL FLYOVER CONSERVATIVES SHOWS - https://flyover.live/show/flyoverTO WATCH ALL FLYOVER CONSERVATIVES SHOWS - https://flyover.live/show/flyoverTO WATCH ALL FLYOVER CONTENT: www.flyover.liveTO WATCH ALL FLYOVER CONTENT: www.flyover.liveDr. Bryan Ardis:Dr. Bryan Ardis:WEBSITE: https://thedrardisshow.com WEBSITE: https://thedrardisshow.comhttps://thedrardisshow.com TELEGRAM: https://t.me/thedrardisshowTELEGRAM: https://t.me/thedrardisshowhttps://t.me/thedrardisshowEVENT: https://healingfortheages.com/ EVENT: https://healingfortheages.com/https://healingfortheages.com/ BOOK: https://thedrardisshow.com/beyond-c-19-lies-book/#video BOOK: Send us a message... we can't reply, but we read them all!Support the show► ReAwaken America- text the word FLYOVER to 918-851-0102 (Message and data rates may apply. Terms/privacy: 40509-info.com) ► Kirk Elliott PHD - http://FlyoverGold.com ► My Pillow - https://MyPillow.com/Flyover ► ALL LINKS: https://sociatap.com/FlyoverConservatives
Tonight at 8:30 pm CST, on the Flyover Conservatives show we are tackling the most important things going on RIGHT NOW from a Conservative Christian perspective! Tonight at 8:30 pm CST, on the Flyover Conservatives show we are tackling the most important things going on RIGHT NOW from a Conservative Christian perspective! TO WATCH ALL FLYOVER CONSERVATIVES SHOWS - https://flyover.live/show/flyoverTO WATCH ALL FLYOVER CONSERVATIVES SHOWS - https://flyover.live/show/flyoverTO WATCH ALL FLYOVER CONTENT: www.flyover.liveTO WATCH ALL FLYOVER CONTENT: www.flyover.liveDr. Bryan Ardis:Dr. Bryan Ardis:WEBSITE: https://thedrardisshow.com WEBSITE: https://thedrardisshow.comhttps://thedrardisshow.com TELEGRAM: https://t.me/thedrardisshowTELEGRAM: https://t.me/thedrardisshowhttps://t.me/thedrardisshowEVENT: https://healingfortheages.com/ EVENT: https://healingfortheages.com/https://healingfortheages.com/ BOOK: https://thedrardisshow.com/beyond-c-19-lies-book/#video BOOK: Send us a message... we can't reply, but we read them all!Support the show► ReAwaken America- text the word FLYOVER to 918-851-0102 (Message and data rates may apply. Terms/privacy: 40509-info.com) ► Kirk Elliott PHD - http://FlyoverGold.com ► My Pillow - https://MyPillow.com/Flyover ► ALL LINKS: https://sociatap.com/FlyoverConservatives
Send us a textFor more episodes of MedStar Health DocTalk, go to medstarhealth.org/doctalk.
Dr. Robbins is back with his monthly Q&A - if you have questions send them to live@cyborg4life.com. Discussing limb lengthening questions from patients who are planning to undergo or have undergone limb lengthening surgery. ____________ Reach out to Dr. Robbins Website: https://limblengthening.org Book consult - https://paley.thec4llective.com Main Point of Contact - Angelique Keller - Director of Stature Lengthening 1) Email: akeller@paleyinstitute.org 2) Instagram: Stature - https://www.instagram.com/paleystaturelengthening/ 3) YouTube: Stature - https://www.youtube.com/@UCBDZvE1b-EEJm9ubxEctmyg ________ Audio Podcast: will be available within 48hrs when stream ends Timestamps: 00:00 - Intro02:00 - Special Mention: Marshall the Mascot & Dr. Robbins' Family Update05:00 - Upcoming Event Highlights: Halloween Party Plans07:30 - Monthly Q&A Overview & Key Topics Preview10:00 - First Question: Reusing Leg Nails for Arm Lengthening15:00 - Approach to Surgery: Staggered vs. Simultaneous Lengthening20:00 - Pain Management During Lengthening: Is Pausing Helpful?25:00 - IT Band Release: Superficial vs. Deep Differences30:00 - Importance of IT Band for Mobility and Stability35:00 - Explanation of Knee Clicking and Duration of Symptoms40:00 - Leg Length Difference Case Study and Prevention Tips45:00 - Hospital Routine After Surgery: Day-by-Day Walkthrough52:00 - Blood Clots and Risk Mitigation Strategies58:00 - Weight Loss and Metabolism Changes After Surgery1:05:00 - Addressing Bowed Femurs During Lengthening1:10:00 - Considerations for Quadrilateral Surgery and Functional Outcomes1:20:00 - Precise Max Nail Recovery and Long-Term Functionality1:25:00 - Dr. Robbins' Running Story & Personal Weight Loss Journey1:30:00 - Closing Remarks ________
In 1898, Sarah Ware went missing from her New England town of Bucksport, Maine. For two weeks, no one bothered to search for her, assuming she'd left town for a new job. But on October 2nd, a grisly discovery was found less than a mile from her house. Join us to hear what happened to Sarah Ware and why she's said to still haunt the town today.Tea of the Day: Front Porch Special Theme Music by Brad FrankSources:“Mrs. Ware's Strange Death.” Lewiston Evening Journal, Mon, Oct 03, 1898, Page 3, https://www.newspapers.com/image/827996586/In Search of Sarah Ware: Reinvestigating Murder and Conspiracy in a Maine Village by Emeric Spooner - CreateSpace Independent Publishing Platform (March 14, 2008)“Sarah Ware Was Murdered.” Lewiston Evening Journal, Tue, Oct 04, 1898, Page 1, https://www.newspapers.com/image/827996602/“Murder, By Her Friend.” Bangor Daily Commercial, Wed, Oct 05, 1898, Page 1, https://www.newspapers.com/image/1105983670/“Mrs. Ware's Death Wound.” Bangor Daily Commercial, Sat, Oct 08, 1898, Page 6, https://www.newspapers.com/image/1105983711/“Some Think it Was Suicide.” Bangor Daily Commercial, Tue, Oct 11, 1898, Page 6, https://www.newspapers.com/image/1105983739/“Strengthens The Theory.” Bangor Daily Commercial, Thu, Oct 13, 1898, Page 3, https://www.newspapers.com/image/1105983756/“All Clews Look Alike.” Bangor Daily Commercial, Thu, Oct 20, 1898, Page 1, https://www.newspapers.com/image/1105983818/“No Clue Can Be Found.” Daily Kennebec Journal, Mon, Oct 31, 1898, Page 1, https://www.newspapers.com/image/857079483/“Bucksport Won't Give Up The Case.” Bangor Daily Commercial, Thu, Nov 03, 1898, Page 3, https://www.newspapers.com/image/1105983956/“New Clues Discovered.” Bangor Daily Commercial, Mon, Nov 07, 1898, Page 1, https://www.newspapers.com/image/1105983994/“There Is Evidence.” Bangor Daily Commercial, Tue, Nov 08, 1898, Page 3, https://www.newspapers.com/image/1105984004/“Odlin Goes Back.” Bangor Daily Commercial, Wed, Nov 09, 1898, Page 3, https://www.newspapers.com/image/1105984016/“Problem of Bucksport Journal.” Lewiston Evening Journal, Fri, Nov 11, 1898, Page 1, https://www.newspapers.com/image/827997304/“Remains to Be Disinterred.” Daily Kennebec Journal, Mon, Nov 21, 1898, Page 7, https://www.newspapers.com/image/857079976/“Blood Clots on Canvas.” Lewiston Evening Journal, Sat, Nov 26, 1898, Page 3, https://www.newspapers.com/image/828060211/“Still a Mystery.” Daily Kennebec Journal, Mon, Nov 28, 1898, Page 1, https://www.newspapers.com/image/857080101/“An Arrest At Last.” Lewiston Evening Journal, Fri, Mar 10, 1899, Page 1, https://www.newspapers.com/image/827983567/“Arrested for Ware Murder.” Bangor Daily Commercial, Fri, Mar 10, 1899, Page 1, https://www.newspapers.com/image/1105903161/“Treworgy Arraigned.” Lewiston Saturday Journal, Sat, Mar 11, 1899, Page 1, https://www.newspapers.com/image/827983719/Treworgy Held for Grand Jury.” Bangor Daily Commercial, Sat, Mar 11, 1899, Page 1, https://www.newspapers.com/image/1105903380/“Case Against Treworgy.” Lewiston Evening Journal, Mon, Mar 13, 1899, Page 3, https://www.newspapers.com/image/827984222/“Fogg Confesses.” Daily Kennebec Journal, Wed, Mar 15, 1899, Page 1, https://www.newspapers.com/image/857026331/“Is Will Treworgy Shielding the Real Ware Murderers.” Bangor Daily Commercial, Thu, Mar 16, 1899, Page 1, https://www.newspapers.com/image/1105904098/“Ware Murder.” The Lewiston Daily Sun, Wed, Mar 22, 1899, Page 1, https://www.newspapers.com/image/828089069/“Retracts Again.” Lewiston Evening Journal, Thu, Mar 23, 1899, Page 5, https://www.newspapers.com/image/827985641/“Bucksport Agog.” Daily Kennebec Journal, Fri, Mar 24, 1899, Page 1, https://www.newspapers.com/image/857027228/“Hall Knows The Guilty Party.” Bangor Daily Commercial, Fri, Mar 24, 1899, Page 1, https://www.newspapers.com/image/1105905468/“Fogg Retracts Again; Treworgy Talks Freely.” Bangor Daily Commercial, Sat, Mar 25, 1899, Page 1, https://www.newspapers.com/image/1105905654/“Retraction No. 4.” Bangor Daily Commercial, Mon, Mar 27, 1899, Page 3, https://www.newspapers.com/image/1105905918/“Will Treworgy Be Indicted?” Bangor Daily Commercial, Wed, Apr 12, 1899, Page 2, https://www.newspapers.com/image/1106723620/“Case Falls to Ground.” The Portland Daily Press, Thu, Apr 13, 1899, Page 1, https://www.newspapers.com/image/814242883/“Sarah Ware Case Opens on Tuesday.” The Bangor Daily News, Wed, Jul 16, 1902, Page 1, https://www.newspapers.com/image/662706780/“Most Dramatic!” Lewiston Evening Journal, Tue, Jul 15, 1902, Page 1, https://www.newspapers.com/image/828109384/“Mysterious Noise at Night.” and “Good Progress Made Tuesday.” Bangor Daily Commercial, Wed, Jul 16, 1902, Page 3, https://www.newspapers.com/image/1105968755/“Good Progress Being Made.” Bangor Daily Commercial, Thu, Jul 17, 1902, Page 3, https://www.newspapers.com/image/1105968805/“It Waxes Exciting!” Lewiston Evening Journal, Fri, Jul 18, 1902, Page 1, https://www.newspapers.com/image/828110036/“Trewrotgy's Story.” Fall River Globe, Wed, Jul 23, 1902, Page 1, https://www.newspapers.com/image/603686796/“Verdict, Not Guilty.” Lewiston Evening Journal, Fri, Jul 25, 1902, Page 1, https://www.newspapers.com/image/828111674/Treworgy Case Goes to the Jury.” The Bangor Daily News, Fri, Jul 25, 1902, Page 1, https://www.newspapers.com/image/662707509/“Who Killed Sarah Ware.” By Sam E.Conner, Lewiston Journal Magazine Section, Sat, Apr 11, 1931, Page 15, https://www.newspapers.com/image/828892991/“Beating a Horse.” Daily Kennebec Journal,Sat, Jul 02, 1904, Page 1, https://www.newspapers.com/image/857209334/“Head Buried at Last.” By Catherine Hines, The Bangor Daily News, Sat, Sep 12, 1998,Page 22, https://www.newspapers.com/image/664214741/“Locker Holds Gruesome Memories…” By Jean Hay, The Bangor Daily News,Sat, Jul 10, 1982, Page 3, https://www.newspapers.com/image/665229528/Maine Ghost Hunters, November 3, 2023, http://www.maineghosthunters.org/2023/11/03/sarah-ware-and-the-haunting-of-silver-lake/“Silver Lake Park Might Just Be The Most Haunted Park In Maine.” By Marla S, Only in Maine, Published Sep 1, 2021, https://www.onlyinyourstate.com/experiences/maine/haunted-park-maine
Superimposed on an impressive body of work on the blood-brain-barrier and immune system, Prof Akassoglou and her collaborators just published an elegant study in Nature that centered on the direct binding os the SARS-CoV-2 spike protein to fibrin with marked downstream pro-inflammatory effects. The findings and potential treatments have implications beyond Covid, Long Covid to other neurologic diseases.Full videos of all Ground Truths podcasts can be seen on YouTube here. The audios are also available on Apple and Spotify.Transcript with links to audio and to relevant papers, graphicsEric Topol (00:07):Well, hello this is Eric Topol with Ground Truths, and with me today is Katerina Akassoglou. She is at the Gladstone Institute and she is a remarkable neuroimmunologist who has been doing extraordinary work for three decades to unravel the interactions between the brain, blood vessels and the role of inflammation. So Katerina, there's a lot to discuss, so welcome.Katerina Akassoglou (00:40):Thank you. Thank you so much. It's a great pleasure to join.By Way of BackgroundEric Topol (00:43):It's really interesting going back in your career. First of all, we're thankful that you immigrated here from Greece, and you have become one of the leading scientists in this discipline of important discipline of neuroimmunology, which is not just about Covid that we're going to talk about, but Alzheimer's and neurodegenerative diseases. This is a really big hot area and you're definitely one of the leaders. And what I was impressed is that all these years that you've been working on the integrity of the blood-brain barrier, the importance of fibrinogen and fibrin, and then comes along the Covid story. So maybe what we can do is start with that, which is you've made your mark in understanding this whole interaction between what can get into the brain, through the blood-brain barrier and incite inflammation. So this has been something that you've really taken to the extreme knowledge base. So maybe we can start with your work there before we get into the important seminal Nature paper that you recently published.Katerina Akassoglou (01:57):Yes, of course. So since very early on, I was still a graduate student when we made the first discovery and at the time was like mid-90s, so it was really ahead of its time. That dysregulation of cytokine expression in the brain of mice was sufficient to induce the whole cascade of events, triggering neurodegeneration, demyelination in pathological alterations, very reminiscent of multiple sclerosis pathology. And it was really hard to publish that study at the time because it was not yet accepted that this regulation of the immune system modeling the brain can be linked to neurodegeneration. So that was 1995 when we made that discovery, and I became really interested, what are the pathogenic triggers that actually polarized the immune cells in the brain? So with this, of course, this transgenic animal was expressing TNF, it was an artificially made animal that we made, but naturally what were the triggers that would polarize the innate immune cells? So I looked really early on in this mice and what I found was that the very first event was leaks of blood-brain barrier. It was opening of the blood-brain barrier in this mouse before inflammation, before demyelination, before neuronal loss. And this is really what shaped the question that, is it possible that these blood leaks that happened very early in the pathology, could this be the instigators of pathogenic inflammation in the brain?Eric Topol (03:34):Yeah. So in a way, you got at this question because of the chicken-and-egg and what happens first, and you got to the temporal saying, which happened first as you said, the leak before you could see evidence of inflammation and being able to study this of course in the experimental model, which you couldn't really do in people. And what I love about the description of your career, which has been quite extraordinary contributions is connecting the dots between the blood, the inflammatory response and the brain. Perhaps no one has done that like you have. And before we get into the recent paper, a lot of people are not aware that a year ago, a group in the UK known as PHOSP-COVID, they published a really important paper in Nature Medicine of over 1,800 people who were hospitalized with Covid and they found that fibrinogen was the best marker for cognitive deficits at 6 and 12 months (Figure below)(04:40):So that's just one of many papers, but it's a particularly well done study that already before you got into this work that recently published had emphasized fibrinogen. And by the way, again, having spent a lot of years in clots in the arteries, for me, we have to just get it down to fibrinogen plus thrombin gets you to fibrin. Okay, so fibrin is a major player here when fibrinogen is cleaved. So here we have the basis that you established, which is the fibrinogen leakage into the brain, activating inflammation, activating microglia, which like the macrophages of the brain and inciting the whole process. And before we close, I want to not just talk about Covid, but Alzheimer's too. But now let's get into the study that you did, [Fibrin drives thromboinflammation and neuropathology in COVID-19] which is striking, I mean really striking. And can you kind of take us through, because you not only demonstrated the importance of fibrin in inciting neuroinflammation in this model, but also how you could reverse it or prevent it. So this, and you looked at it in many different ways, this was a systematic approach. Maybe you can take us through how you were able to make such compelling evidence.The Multimodal EvidenceKaterina Akassoglou (06:09):Yes, thank you. First of all, thank you for bringing up the human relevance because this was also our inspiration for the work that we did in the Covid study. So as you mentioned in Covid patients, fibrinogen unbiased mass spec analysis was identified as the predictive biomarker for cognitive impairment in Long Covid patients. And this was in addition to also neuropathology data about the abundance of fibrin deposition in the brain. And these were studies that were done by NIH that have found deposition of fibrin in the brain and the reports for the abnormal and puzzling coagulation in Covid that is not setting other infections and also in many cases not always relating with the severity of symptoms. So even mild cases of Covid also had increased coagulation. I was really intrigued by this human, all this evidence in human data, and I thought that maybe the way that we're thinking about this, that it's systemic inflammation that drives the clotting.(07:24):Maybe there's another aspect to this. Maybe there is a direct effect of the virus with the coagulation cascade, and in this way maybe this can be an instigator of inflammation. So this was the original idea to be able to reconcile this data from the clinic about why do we have this prevalence of coagulopathy in Covid. And of course, the second question is, could this also be a driver of the disease? And of course, we're in a unique position because we have been studying this pathway now for over 20 years to have all the toolbox, the genetic toolbox, the pharmacologic toolbox to be able to actually really address these questions with genetic loss of function studies, with a blood innate immunity multiomics pipeline that we have set up in the lab. And of course, with preclinical pharmacology in our ABSL3 facility. So we had the infrastructure in place and the source in place to actually really dissect this question with both genetic tools as well as also technology platforms.Eric Topol (08:29):And you had in vivo imaging, you're the director of in vivo imaging for Gladstone and UCSF. So you do have the tools to do this.Katerina Akassoglou (08:38):Yes. The imaging that you mentioned is really important because this is, we employed that very early in our studies over now 15 years ago. And the reason was sometimes from snapshots of histopathology, you cannot really understand the sequence of events. So by being able to image these processes, both neuronal activity, microglia activation, infiltration of peripheral cells in the brain, this is how we could see the steps that what happens early on and to be able to answer these chicken-and-egg questions that you mentioned. So these were very, they're very important experiments, especially at the beginning because they were hypothesis driving and we were able to ask the right questions to drive our research program.Eric Topol (09:26):Now was the binding of the spike protein to one key site in fibrinogen, was that known before? [See outstanding Figure below from Trends in Immunology]Katerina Akassoglou (09:36):No, this was not known. So there was evidence that there are abnormal clots in Covid, but it was not known whether the spike protein would directly bind to protein to the coagulation cascade. So one of the key discoveries in our study was to use peptide array mapping and be able to identify not only the binding, but exactly the domains on fibrin that spike binds too. And what we found was two key domains, one the inflammatory domain and the other the plasmin binding site, which is important for fibrin degradation. So this suggested a potential dual deleterious role for this interaction, both by maybe affecting inflammation, but also delaying fibrinolysis, which is the degradation of this toxic protein from the brain. And indeed, we found that this interaction was responsible for all these two aspects, including decreased degradation, more inflammation, but also at the same time increased, increased coagulation. So it was a really pathogenic interaction.Eric Topol (10:47):Yeah, actually it's pretty striking. You have these two sites, the plasmin cleavage site of fibrinogen, which as you say, we knew there was a problem with clots. We knew that, but we didn't know exactly the spike protein how exactly it was implicated, particularly with fibrinogen. And then this other site, the CD11b-C18, now that's fancy for surface receptors of macrophages. And basically, this is critical because it's this microglia activation in the brain, and I know you saw it in the lungs as well through this other site that spike protein activated. So you had a twofer here of things that you discovered that the SARS-CoV-2 spike protein was capable of doing. This was a really big revelation. And then you also looked at mice that were genetically manipulated. So maybe you can, because before we get to your antibody monoclonal, the ways that you proved this were, I mean, one thing after another is really systematic. So maybe you can teach us about that.Thanks for reading Ground Truths! This post is public so feel free to share it.Establishing CausalityKaterina Akassoglou (12:08):Yeah, sure. So the first was about chemistry experiment. So this of course, we had to get to the next step to see is there any causality for this pathway. So we employed genetic loss of function studies and we had knockout mice, either fibrinogen knockout mice, this mice have all blood proteins except fibrinogen, and they have a delay in coagulation so they don't clot properly. But we also had a mutant mouse, which is a fibrinogen NK mouse. And this was a mutation only within this inflammatory domain that you mentioned, inflammatory domain that binds to C11b-C18. Other names for this is of course complement receptor 3, Mac-1 (αMβ2). It's the same, many names for this receptor, that as you mentioned, is expressed not only in microglial in the brain, but also peripheral immune cells including macrophages as well as also neutrophils which are CD11b expressing.(13:12):So we now have genetic models to be able to look at both complete depletion of fibrinogen, but also a very specific mutation and very selective mutation that only blocks the inflammatory properties without affecting the properties of fibrin in hemostasis. And these mice were made many years ago by a very close collaborator, Jay Degen at the University of Cincinnati. So what we found is that when we block either the inflammatory domain or we completely deplete fibrinogen, there was this profound protection after infection in internasal infection with the virus in lung inflammation. And this was both suppression of oxidative stress and this pathogenic inflammation in the lung, but also decreasing fibrosis, which has been associated with also Long Covid. And the surprise came from the transcriptomic data. So when we did transcriptomic analysis in this mice in the lungs, we found perhaps the expected decrease in the immune signatures in macrophages. This was in line with our previous work in, as you mentioned, Alzheimer's models, multiple sclerosis models. But what also was really surprising is there was that genes that are associated with activation of NK cells were upregulated. And of course this was the first time we had infected these mice, previously we had not done an infection before. So I think that maybe because of this region we had not seen before in our data this immunomodulatory role of fibrin that not only surprises the macrophage response, but also increases these NK cells that are important for viral clearance.Eric Topol (15:00):So again, the finding another important unique finding is the natural killer (NK) cells and effect there from the activation of this, as you said, the inflammation site or the CD11b-C18 that we've been talking about. So now another layer of this, a dimension of your Nature paper was that you tested an antibody that you already had developed so-called 5B8. A monoclonal that specifically binds to the domain of the one we're talking about this inflammation domain of fibrinogen. So can you tell us about what that showed?Katerina Akassoglou (15:45):Yes, so we tested this antibody in different models of Covid, which were both models with neuroinvasion and models without neuroinvasion. So we used both transgenic mice for hACE2, the human ACE2 infected with Delta, but we also use mouse adapted viruses like Beta that is just in the wild type mice with no transgenic being involved that these are without neuroinvasion. And we wanted to see if the antibody had any potential protective effects. And what we found is that the antibody protected from inflammation in the lung. So the data looked so similar with a genetic mutation of this pathway, protection from inflammation, decreased fibrosis, increased viral clearance, so decreased spike and viral proteins in the lungs. But we also found a protection in the brain. So the brains of this mice, including both the models we used with neuroinvasion and without, they both have had microglia activation in the brain. And we also found neuronal loss in the Delta infected mice and the antibody protected from both neuroinflammation but also improved neuronal survival in the mice. Showing that there can be this despite regardless of which model we used, there was this protective effect suggesting that by blocking fibrin, either the periphery or in the brain, this could be protected for these models.Eric Topol (17:28):Yeah, so I mean this is fascinating because until now, until this report of yours and your colleagues at Gladstone, there was knowledge that there would be neuroinflammation from Covid, both in patients from various biomarkers and imaging as well as in experimental model. But what this did was take it to the fibrin story, and I guess that's one of the questions you nailed that how important fibrin is, but that doesn't necessarily rule out other triggers of neuroinflammation, right?Katerina Akassoglou (18:04):Oh, absolutely not. So I think that this is one of the mechanisms that can be very important, especially in some patients. But we know that there are additional of course mechanisms of neuroinflammation including auto-antibody responses, as well as also endotheliopathy that are persistent endotheliopathy, this can be interacting also with each other. So I think that it's important for future research that we understand how do these mechanisms feed into each other? Are there a positive feedback loops between autoimmune mechanisms and coagulopathy and endothelial dysfunction with inflammation? But I think most importantly, I think that if we're thinking of this in the context of patients, can we identify patients with mechanism that might be more prevalent in specific cases of Long Covid and tailor our potential future clinical trials towards the needs of Long Covid patients?Towards TreatmentEric Topol (19:06):Absolutely. I did interview some months back on Grounds Truths, Michelle Monje at Stanford, who I'm sure and interact with, and she's also works not so much on the fibrin side, but on neuroinflammation and the likeness between this condition in people and chemo brain because of the inflammation that's seen there. So we've talked about the multiple triggers that could contribute to brain inflammation, which I think most people would say in Long Covid this is one of the most, besides obviously the lack of energy, the profound fatigue and disability, but the cognitive function hit, not just brain fog is often profound. And we've just seen some reports about that, and particularly in hospitalized patients, how bad that can be. So that gets us to a potential treatment. Now, one of the things that's out there dangling, there's many things that people have talked about in terms of why can't we have a treatment for Long Covid?(20:13):And now of course this fibrin pathway, if you will, lends itself to many possibilities, whether it's anticoagulants or fibrinolytics like a tPA or things like nattokinase, which is a Japanese food enzyme that you could get at the nutrition centers or whatever. What are your thoughts? Because we don't have any good studies. There are all these little, tiny studies and they don't provide much conclusion, and you have an antibody that could potentially be effective. As I understand it, you set up a company some years ago, Therini Bio and used to be called MedaRed. You're the first woman scientist at Gladstone to develop a spin out company, which is another point of congratulations on that. But could the antibody be tested in patients or what do you think about these other possibilities?Katerina Akassoglou (21:15):Yes, yes. These are great questions. So first of all, the different approaches that you mentioned have very different mechanism of action. So degrading fibrin, the degradation products of fibrin also can have deleterious effects. The dimer, for example, can be very pro-inflammatory. So at the same time, blocking coagulation can also have a diverse effects because this can lead to excessive hemorrhage. So the approach that we took was to selectively block the inflammatory properties of fibrin without affecting beneficial effects of the molecule in normal hemostasis. So the challenge when I made the antibody was to be able to dissect these two functions of fibrin. It's our most important clotting factor, but at the same time, a molecule with profound pro-inflammatory capacity. So the observation that these two domains, the clotting domain and inflammatory domain were not overlapping, was really the foundation of this invention was that we could maybe create this antibody to be able to target them in a selective way.Other Neurologic Conditions (22:31):So the antibody I developed is neutralizing blood toxicity by blocking the inflammatory domain of fibrin without adverse coagulation effects. And it's now completing phase one trials. So it has already completed the single ascending dose at 40 milligram per kilogram. It's interim data were announced already for this trial, with no safety signals. So if the antibody completes this year, the phase one trials, then it should be possible to be tested in different patient populations. You mentioned before chemo brain, and I think it's important that we think that blood-brain barrier disruption occurs among many neurological conditions, and it's an early event associated with early disease onset and worse prognosis in multiple sclerosis, Alzheimer's disease, traumatic injuries. So I think that it's by developing a strategy, therapeutic strategy to neutralize blood toxicity, this can have applications in a wide range of neurological conditions with vascular dysfunction.Eric Topol (23:54):Yeah, no. In your Nature Immunology 2020 piece [Figure below], you started with the 1883 identification of multiple sclerosis (MS) lesions were “engorged with blood”, the first link between blood leaks and brain inflammation. So this has enormous potential. And what I like about this Katerina is that you've dissected the clot component versus the inflammatory trigger of the fibrinogen and fibrin story. And this is so vital because if you keep throwing these things that just going to work on the clot and not deal with the pro-inflammatory consequences, then you're going to get the wrong impression that clots are not that important. And by the way, you did mention, and I want to come back to that too, endothelial inflammation, which is another feature of Long Covid is another kind of interactive part of this because when the lining of the blood vessel is inflamed, it will attract microthrombi and also be a participant in this whole affair. What do you think about Alzheimer's and the prospects of being able to interfere with Alzheimer's? We have 20 years in someone before this process takes hold and meets clinical manifestations. Would an antibody like this ever be useful along the way?Katerina Akassoglou (25:29):Yeah, so well, our antibody was tested first in Alzheimer's, this models when it was originally published, and we performed reversal trials in Alzheimer's models. So we dosed mice when they have established amyloid plaques, microglia activation, neuronal loss, and we could reverse this effect so it could increase cholinergic neurons in mice, reduce inflammation in a very selective way, only the neurotoxic part of inflammation and for genetic depletion of this pathway with akin mice in Alzheimer's disease. Also, improves from cognitive impairment, and we now have a new paper in Cell Press that is showing this effects also with really nice and unbiased machine learning models for behavioral segmentation [Figure below].So I think that there is the data both from genetic studies and the antibody show projection in Alzheimer's disease. And of course, as you might have read the recent Lancet report from the Lancet committee on dementia that identified the vascular risk factors as the key contributors, especially post sporadic cases of Alzheimer's disease that is over 90% of Alzheimer's disease that is not genetically linked.(26:58):So I think that there is a real need in Alzheimer's disease to be able to block this vascular induced pathology. And an antibody like the fibrin neutralizing therapy could be positioned to be protective from the vascular induced immune-mediated neurodegeneration in this disease as well. I mean, ultimately, I think that we need to be thinking the terms of efficacy. So we want to have a drug that is efficacious, but we also want it to be selective. And the selectivity is really important because the immune system has so many protective functions. So if we block phagocytosis, we end up with more debris, decrease of neurorepair, anti-myelination. So by blocking a ligand here and not blocking, not eliminating a cell type or blocking a global pathway in this cell, but biologic a single ligand, I think we have been able to achieve this balance between efficacy, but also safety because we only block this neurotoxic populations and not the entire innate immune response that also has been beneficial for metastatic functions in the brain.Blocking NeuroinflammationEric Topol (28:19):So you're bringing up another critical concept about targeting the inflammation, this kind of goldilocks story of how much you interfere with the immune response and how much you are able to reduce the adverse pro-inflammatory effects. So that gets me to what if we don't know in any given patient how much fibrin is having a role in their Long Covid. Although we know it has to be a prominent feature because we saw it in, not just a hospitalized patient series that I mentioned we reviewed, but other papers as well. But what about if you just try to take on inflammation like through a GLP-1 drug or cGAS–STING or any of these really strong anti-inflammatory pathways. Do you see a difference in a generalized approach versus a specific approach that is really fibrin centered?Katerina Akassoglou (29:22):Yeah, so we have a focus actually on both because we wanted to dissect the downstream intracellular pathways of fibrin, and it's interesting that we can find specific inflammatory mediators that potentially can also be targeted as well, to be able to preserve that specificity, which I think is really important because if we don't preserve the specificity, we'll end up with a lot of adverse effects by eliminating major immune responses. But the point that you raised I think is really important because it's not enough to have an efficacious and selective drug if you don't know the patient population that will benefit from this drug. So I think that in addition to the drug discovery studies, it's important to develop also biomarker programs with both fluid biomarkers, but also imaging biomarkers to be able to identify the patient populations that will benefit from such treatment.(30:25):So if for example, a patient population has a fibrin deposition, blocking only downstream might not be enough, and it might be really important to neutralize this fibrin toxicity in the brain of patients. And with our target engagement studies, we show that at least in animal models, the antibody can be there. So I'm very encouraged by also programs that are going on now in the scientific community to develop noninvasive ligands to be able to image fibrin in the brain that are already tested in different patient populations like multiple sclerosis. Because I think we're going to learn so much from the biology as we start interrogating and asking these questions now in different patient populations.Eric Topol (31:14):I think that's a vital point you're making because the success of a clinical trial here in a clinical syndrome that is mosaic with lots of different types of pathways. If you can nail down the patients that would have the most to stand to benefit from a particular intervention, that the chance of you not missing the benefit that is matching the marker, what image marker or other markers is so vital. Well, we've talked, I think, about some fascinating discoveries that you and your colleagues have made. I mean, it's really extraordinary, and obviously we need this in Long Covid. But you know what, Katerina, it's almost made me think that you were warming up to this for three decades, that somehow or other you were working on all this stuff and then came Covid. Is that how you see it, that somehow or other you didn't know that all the work you were doing was going to wind up in this space?Katerina Akassoglou (32:18):Oh, I never thought I would work in a virology project. This collaboration started over Zoom with Warner Greene. We were both sheltering in place. It was the beginning of the pandemic, and the first reports were coming out about this puzzling coagulopathy. And our labs were hardly operational at the time, as you know, we had to close down our labs for a while. And however, this was a very big problem, and we thought that this is our role as scientists. If we feel that we can contribute and we have the tools to contribute, we felt that it's important that we pivot some part of our research, and even we wouldn't be doing this before, but it was important to pivot a part of our research and collaborate. And I think studies like this, this study would have been impossible without a team of collaborators. As you know, there were over 50 scientists involved at Gladstone, UCSF, UCLA, UCSD, Stanford University. Without collaboration, this study wouldn't be possible. So I'm really grateful to everyone who came together to solve this problem because I think that's what scientists should be doing. We should be solving problems as they arise.Eric Topol (33:41):Well, and also, I think a lot of people don't realize that, for example, when the Covid vaccines came along, people think, oh, well, it all got done in 10 months since the sequence of the virus, when in fact it took 30 years at least between all the factors that went into having an mRNA and sequencing virus and nanoparticles. And in many ways, your arc of this work is like that because it took three decades to have all the tools and the basic understanding, the antibody that you had developed for different reasons and this fascinating unraveling of what's going on in the model and undoubtedly in some patients at least as well. So before we wrap up, have I missed anything about this just remarkable work you've done?Katerina Akassoglou (34:33):Oh, thank you. I just want to thank you for this discussion and thank you for emphasizing the different areas and the different decisions that this pathway can have implications both for our understanding, our basic understanding of the blood brain immune interface, as well as also potential translation. And I think that the curiosity sometimes of how things work, I never thought it would work on Covid, like you mentioned at the beginning, but I think that basic science and curiosity driven science can sometimes lead to discoveries with translational implications that hopefully might benefit patients one day.Eric Topol (35:21):Yeah, well, undoubtedly it will. We're indebted to you, Katerina and all the folks that you have teamed up with, connecting the dots at the neurovascular interface. Phenomenal work and will follow the subsequent with great interest and it will likely not just a story about Long Covid, but other areas as well, so thank you.*********************************Thanks for listening, reading or watching!The Ground Truths newsletters and podcasts are all free, open-access, without ads.Please share this post/podcast with your friends and network if you found it informative!Voluntary paid subscriptions all go to support Scripps Research. Many thanks for that—they greatly help fund our summer internship programs.Thanks to my producer Jessica Nguyen and Sinjun Balabanoff for audio and video support at Scripps Research.Note: you can select preferences to receive emails about newsletters, podcasts, or all I don't want to bother you with an email for content that you're not interested in. Get full access to Ground Truths at erictopol.substack.com/subscribe
TO WATCH ALL FLYOVER CONTENT: www.flyover.liveTO WATCH ALL FLYOVER CONTENT: www.flyover.liveDr. Bryan Ardis:Dr. Bryan Ardis:WEBSITE: https://thedrardisshow.comWEBSITE: https://thedrardisshow.comTELEGRAM: https://t.me/thedrardisshowTELEGRAM: https://t.me/thedrardisshowhttps://t.me/thedrardisshowEVENT: https://healingfortheages.com/ EVENT: https://healingfortheages.com/https://healingfortheages.com/ Promo Code: FLYOVERPromo Code: FLYOVERIN STUDIO INTERVIEW with Dr. Ardis: https://rumble.com/v3kst6j-dr.-bryan-ardis-the-10-things-you-need-to-know.html IN STUDIO INTERVIEW with Dr. Ardis: https://rumble.com/v3kst6j-dr.-bryan-ardis-the-10-things-you-need-to-know.htmlhttps://rumble.com/v3kst6j-dr.-bryan-ardis-the-10-things-you-need-to-know.html --------------------------------------------------------------------------------------
TO WATCH ALL FLYOVER CONTENT: www.flyover.liveTO WATCH ALL FLYOVER CONTENT: www.flyover.liveGET YOUR TICKETS: https://healingfortheages.com/ GET YOUR TICKETS: https://healingfortheages.com/https://healingfortheages.com/ Promo Code: FLYOVERPromo Code: FLYOVERIn 2023, Drs. Ardis, Group, Ealy & Schmidt launched a movement to return the medicine God intended for us all to the pinnacle of the medical mountain where it deserves to be.In 2023, Drs. Ardis, Group, Ealy & Schmidt launched a movement to return the medicine God intended for us all to the pinnacle of the medical mountain where it deserves to be.At the A.G.E.S. Annual Fall Conference 2023, the Fantastic 4 Natural Docs showed you how to prevent bioweapons from getting into your body!At the A.G.E.S. Annual Fall Conference 2023, the Fantastic 4 Natural Docs showed you how to prevent bioweapons from getting into your body!At the A.G.E.S. Virtual Solution Summit 2024, the Fantastic 4 showed you how to neutralize EMF bioweapons connecting to the magnificent healing power of Mother Earth!At the A.G.E.S. Virtual Solution Summit 2024, the Fantastic 4 showed you how to neutralize EMF bioweapons connecting to the magnificent healing power of Mother Earth!Now, at the A.G.E.S. Annual Fall Conference 2024, the Fantastic 4 are at it again… and this time, with a little help from their friends.Now, at the A.G.E.S. Annual Fall Conference 2024, the Fantastic 4 are at it again… and this time, with a little help from their friends.If you joined us in person last year, you already know how incredible it felt to be in attendance. Like a real family reunion. GREAT NEWS, this year is going to be even better!If you joined us in person last year, you already know how incredible it felt to be in attendance. Like a real family reunion. GREAT NEWS, this year is going to be even better!GUESTS:GUESTS:Dr. Bryan Ardis:Dr. Bryan Ardis:WEBSITE: Send us a message... we can't reply, but we read them all!Support the show► ReAwaken America- text the word FLYOVER to 918-851-0102 (Message and data rates may apply. Terms/privacy: 40509-info.com) ► Kirk Elliott PHD - http://FlyoverGold.com ► My Pillow - https://MyPillow.com/Flyover ► ALL LINKS: https://sociatap.com/FlyoverConservatives
Ever wondered if it's possible to safely undergo plastic surgery with a history of blood clots?In this eye-opening episode of "Plastic Surgery Uncensored," Dr. Rady Rahban tackles this important question by sharing the story of his patient Lori. Despite medical challenges like a pulmonary embolism, Lori courageously pursued her goal of having a tummy tuck. Together, she and Dr. Rahban reveal the steps taken to ensure her safety, including the vital role her healthcare team—especially her hematologist—played in creating a successful plan.This episode is filled with valuable insights for anyone considering surgery with underlying medical conditions. Tune in to hear Lori's inspiring journey, learn about the power of collaboration in healthcare, and discover how self-advocacy can lead to safe, life-changing results!Get In Touch With Dr. Rahban!
Roger Seheult, MD, of MedCram explores data related to the effects of anticoagulation medications on bleeding and blood clots to help determine when a patient should stop using those medications. See all Dr. Seheult's videos at: https://www.medcram.com/ (This video was recorded on August 22nd, 2024) Roger Seheult, MD is the co-founder and lead professor at https://www.medcram.com He is Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine and an Associate Professor at the University of California, Riverside School of Medicine. MEDCRAM WORKS WITH MEDICAL PROGRAMS AND HOSPITALS: MedCram offers group discounts for students and medical programs, hospitals, and other institutions. Contact us at customers@medcram.com if you are interested. MEDIA CONTACT: Media Contact: customers@medcram.com Media contact info: https://www.medcram.com/pages/media-contact Video Produced by Kyle Allred FOLLOW US ON SOCIAL MEDIA: https://www.facebook.com/MedCram https://twitter.com/MedCramVideos https://www.instagram.com/medcram DISCLAIMER: MedCram medical videos are for medical education and exam preparation, and NOT intended to replace recommendations from your doctor. #bloodclot #anticoagulants #bleeding
TO WATCH ALL FLYOVER CONTENT: www.flyover.liveTO WATCH ALL FLYOVER CONTENT: www.flyover.liveDr. Bryan Ardis:Dr. Bryan Ardis:WEBSITE: https://thedrardisshow.comWEBSITE: https://thedrardisshow.comTELEGRAM: https://t.me/thedrardisshowTELEGRAM: https://t.me/thedrardisshowhttps://t.me/thedrardisshowEVENT: https://healingfortheages.com/ EVENT: https://healingfortheages.com/https://healingfortheages.com/ Promo Code: FLYOVERPromo Code: FLYOVERIN STUDIO INTERVIEW with Dr. Ardis: https://rumble.com/v3kst6j-dr.-bryan-ardis-the-10-things-you-need-to-know.html IN STUDIO INTERVIEW with Dr. Ardis: https://rumble.com/v3kst6j-dr.-bryan-ardis-the-10-things-you-need-to-know.htmlhttps://rumble.com/v3kst6j-dr.-bryan-ardis-the-10-things-you-need-to-know.html --------------------------------------------------------------------------------------
Friday August 16, 2024 Zero calorie sweetener linked to blood clots and risk of heart disease
Tonight at 8:30 pm CST, on the Flyover Conservatives show we are tackling the most important things going on RIGHT NOW from a Conservative Christian perspective! Tonight at 8:30 pm CST, on the Flyover Conservatives show we are tackling the most important things going on RIGHT NOW from a Conservative Christian perspective! TO WATCH ALL FLYOVER CONSERVATIVES SHOWS - https://flyover.live/show/flyoverTO WATCH ALL FLYOVER CONSERVATIVES SHOWS - https://flyover.live/show/flyoverTO WATCH ALL FLYOVER CONTENT: www.flyover.liveTO WATCH ALL FLYOVER CONTENT: www.flyover.liveDr. Bryan Ardis:Dr. Bryan Ardis:WEBSITE: https://thedrardisshow.comWEBSITE: https://thedrardisshow.comTELEGRAM: https://t.me/thedrardisshowTELEGRAM: https://t.me/thedrardisshowhttps://t.me/thedrardisshowEVENT: https://healingfortheages.com/ EVENT: https://healingfortheages.com/https://healingfortheages.com/ Promo Code: FLYOVERPromo Code: FLYOVERIN STUDIO INTERVIEW with Dr. Ardis: https://rumble.com/v3kst6j-dr.-bryan-ardis-the-10-things-you-need-to-know.html IN STUDIO INTERVIEW with Dr. Ardis: https://rumble.com/v3kst6j-dr.-bryan-ardis-the-10-things-you-need-to-know.htmlSend us a message... we can't reply, but we read them all!Support the Show.► ReAwaken America- text the word FLYOVER to 918-851-0102 (Message and data rates may apply. Terms/privacy: 40509-info.com) ► Kirk Elliott PHD - http://FlyoverGold.com ► My Pillow - https://MyPillow.com/Flyover ► ALL LINKS: https://sociatap.com/FlyoverConservatives
It's time for another Q&A episode. I'm answering listener questions about bioidentical HRT, the risks associated with oral estrogens, and so much more. Additionally, we'll discuss the Mirena IUD's impact on hormone levels, address concerns about loose skin after weight loss, and weigh the pros and cons of different HRT methods for women experiencing premature ovarian deficiency. I'll also provide my insight on the role of diet, thyroid function, and even probiotics in managing HRT side effects. In this episode: Why some women experience quick benefits from bioidentical HRT, while others need more adjustments. The risks associated with oral estrogens, especially for those with the factor V genetic variant. Why transdermal estrogen is a safer alternative to oral forms. How the Mirena IUD affects hormone levels and natural progesterone production. The long-term health implications of synthetic progestins, plus strategies for integrating natural bioidentical progesterone. Concerns about loose skin after weight loss, along with solutions like muscle-building exercises. The pros and cons of different HRT methods for women with premature ovarian deficiency. Why achieving therapeutic hormone levels is crucial for protecting against health risks. How to manage weight gain concerns related to HRT, including adjusting dosages and supporting detoxification pathways. The role of diet, thyroid function, and probiotics in managing HRT side effects. Why a balanced intake of carbohydrates is important for metabolic health. The potential influence of COVID-19 and its vaccine on menstrual health. The necessity and effectiveness of probiotics for gut health. Strategies for improving sleep and managing HRT side effects like headaches and hair growth. How to identify the culprit hormone causing weight gain and swelling by adjusting doses. The efficacy of calcium D-glucarate and N-acetylcysteine in managing estrogen-related weight gain. The importance of monitoring hormone levels despite a doctor's refusal to conduct lab tests. How tirzepatide affects weight loss beyond appetite suppression. LMNT: Order your LMNT electrolytes today and get a FREE 8 pack of samples! Plus try it risk free, they have a no-questions-asked refund policy – you don't even have to send it back! www.drinklmnt.com/KarenMartel Timeline is offering 10% off your first order of Mitopure. Go to www.timeline.com/KARENMARTEL and use code HORMONE to get 10% off your order. Apollo https://apolloneuro.com/karen you can get 15% off your apollo wearable. Interested in joining our NEW Peptide Weight Loss Program? Join today and get the details here. Join our Women's Group Coaching Program OnTrack TODAY! Karen Martel, Certified Hormone Specialist & Transformational Nutrition Coach and weight loss expert. Visit https://karenmartel.com/ Karen's Facebook Karen's Instagram
In this episode, my guest is Dr. Gary Steinberg, MD, PhD, a neurosurgeon and a professor of neurosciences, neurosurgery, and neurology at Stanford University School of Medicine. We discuss brain health and brain injuries, including concussion, traumatic brain injury (TBI), stroke, aneurysm, and transient ischemic attacks (TIA). We discuss key and lesser-known risk factors for brain health and explain how certain treatments and medications can improve brain health and cognitive function. We also cover novel mechanisms to improve recovery after concussions and brain injury, including the use of stem cells, temperature (mild hypothermia), and vagus nerve stimulation. Dr. Steinberg also describes new advances in neurosurgery and minimally invasive brain augmentation. This episode ought to be of interest to anyone seeking actionable tools to improve their brain health and for those seeking to improve recovery after a brain injury such as concussion, stroke, aneurysm, or TBI. For show notes, including referenced articles and additional resources, please visit hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman ROKA: https://roka.com/huberman AeroPress: https://aeropress.com/huberman LMNT: https://drinklmnt.com/huberman Timestamps 00:00:00 Dr. Gary Steinberg 00:01:44 Sponsors: Eight Sleep, ROKA & AeroPress; Subscribe on YouTube, Spotify & Apple 00:06:16 Stroke, Hemorrhage & Blood Clot 00:10:25 Blood Clots & Risk Factors, Medications, Smoking, Cholesterol 00:16:19 Heart & Brain Health; Neurosurgery & Brain Function 00:23:27 Current Technology & Neurosurgery, Minimally Invasive Techniques 00:28:13 Transient Ischemic Attacks (TIA); Spinal Cord Strokes 00:33:23 Stroke Risk: Alcohol, Cocaine & Other Drugs 00:38:24 Sponsor: AG1 00:39:55 Traumatic Brain Injury (TBI), Concussion: Sports, Testing & Recovery 00:46:45 Statins; TBI & Aspirin; Caffeine & Stroke Risk 00:48:31 Exploratory MRI: Benefits & Risks 00:51:53 Blood Pressure, Lifestyle Factors; Tool: Feeling Faint, Hydration; Sleep 00:59:52 Sponsor: LMNT 01:01:27 Chiropractic Neck Adjustment & Arterial Obstruction; Inversion Tables 01:05:16 Kids, Tackle Football, Soccer, Boxing; Mild Concussion 01:10:49 Nerve Regeneration, Stem Cells, Stroke Recovery 01:17:36 Stem Cells, Immune System, Activity 01:21:27 Injury & Recovery, Restraint Therapy 01:23:46 Neuroprotection After Injury; Mild Hypothermia 01:34:59 Platelet-Rich Plasma (PRP), Stem Cell Therapy 01:42:27 Scientific Advancements & Clinical Translation, FDA & Industry 01:47:40 Vagal Stimulation 01:53:17 Zero-Cost Support, Spotify & Apple Reviews, YouTube Feedback, Social Media, Neural Network Newsletter Disclaimer
Jeff kicks off the show with Hurricanes Head Coach Rod Brind'Amour fresh off of a new contract extension. They discuss why the deal took more time than many expected and if there was any doubt that he would be behind the bench in Carolina next season. Next, Sportsnet NHL play-by-play voice Chris Cuthbert joins the program to tee up Game 7 between the Oilers and Canucks and recap Vancouver's poor performance in Game 6 (18:52). Later, Dr. Ali Rendely joins Jeff to discuss Brock Boeser's blood clot and the road to recovery (36:16). They also discuss the relationship between professional hockey and blood clots, her career in sports and medicine, and much more. Finally, wrapping up the show, Dallas Stars analyst Brent Severyn stops by to discuss the Stars' playoff run so far, Pete DeBoer's tactics and how tough it is to play in his system, Wyatt Johnston's huge leap in the postseason, and much more (52:09). The views and opinions expressed in this podcast are those of the hosts and guests and do not necessarily reflect the position of Rogers Sports & Media or any affiliates.
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