Podcasts about Acute

In part one of this two-part series, Dr. Jeff Ratliff and Dr. Brin E. Freund discuss the incidence of acute symptomatic seizures during CAR T-cell therapy.  Show reference:  https://www.neurology.org/doi/10.1212/WNL.0000000000213535   

Episode 194: Acute low back pain.  Future Dr. Ibrahim presents a clinical case to explain the essential points in the evaluation of back pain.  Future Dr. Redden adds information about differentiating between a back strain and more serious diseases such as cancer, and Dr. Arreaza shares information about returning to work after back strain.Written by Michael Ibrahim, MSIV. Editing and comments by Jordan Redden, MSIV, and Hector Arreaza, MD.You are listening to Rio Bravo qWeek Podcast, your weekly dose of knowledge brought to you by the Rio Bravo Family Medicine Residency Program from Bakersfield, California, a UCLA-affiliated program sponsored by Clinica Sierra Vista, Let Us Be Your Healthcare Home. This podcast was created for educational purposes only. Visit your primary care provider for additional medical advice.Dr. Arreaza:Welcome back, everyone. Today's topic is one that every primary care provider, emergency doctor, and even specialist sees routinely: low back pain. It's so common that studies estimate up to 80% of adults will experience it at some point in their lives. But despite how frequent it is, the challenge is to identify which cases are benign and which demand urgent attention.Jordan:Exactly. Low back pain is usually self-limiting and mechanical in nature, but we always need to keep an eye out for the rare but serious causes: things like infection, malignancy, or neurological compromise. That's why a good history and physical exam are our best tools right out of the gate.Michael:And to ground this in a real example, let me introduce a patient we saw recently. John is a 45-year-old warehouse worker who came in with two weeks of lower back pain that started after lifting a 50-lb box. He describes it as a dull, aching pain that radiates from his lower back down the posterior left thigh into the calf. He says it gets worse with bending or coughing, but he feels better when lying flat. He also mentioned some numbness in his left foot, but he denies any bowel or bladder issues. His vitals are completely normal. On exam, he had lumbar paraspinal tenderness, a positive straight leg-raise at 40 degrees on the left and decreased sensation in the L5 dermatome, though reflexes were still intact.Dr. Arreaza:That's a great case. Let's take a minute and talk about the straight leg raise test. This is a bedside tool we use to assess for lumbar nerve root irritation often caused by a herniated disc. ***Here's how it works: the patient lies supine, and you slowly raise their straight leg. If pain radiates below the knee between 30° and 70°, that suggests radiculopathy, especially involving the L5 or S1 nerve roots. Pain at higher angles is more likely due to hamstring tightness or mechanical strain.Michael:Right. So, stepping back: what do we mean by "low back pain"? Broadly, it's any pain localized to the lumbar spine, but it's often classified by type or cause:Mechanical (like muscle strain or degenerative disc disease), Radicular (nerve root involvement), Referred pain (like from pelvic or abdominal organs), Inflammatory (AS), and Systemic or serious causes like infection or malignancy. Jordan:In John's case, we're thinking radicular pain, most likely from a herniated disc compressing the L5 nerve root. That's supported by the dermatomal numbness, the leg pain, and that positive straight leg test.Dr. Arreaza:Good reasoning. Now, anytime we see back pain, our brains should run a checklist for red flags. These help us pick up more serious causes that require urgent attention. Let's run through the red flags.Michael:Sure. For fracture, we think about major trauma or even minor trauma in the elderly, especially those with osteoporosis or on chronic steroids. Also, anyone over 70 years old.Jordan:Then we have infections, which could include things like discitis, vertebral osteomyelitis, or epidural abscess. Red flags include fever, IV drug use, recent surgery, or immunosuppression.Michael:Malignancy is another critical one, especially if there's a history of breast, prostate, lung, kidney, or thyroid cancer. Clues include unexplained weight loss, night pain, or constant pain not relieved by rest.Jordan:And don't forget about inflammatory back pain, like ankylosing spondylitis, which is often seen in younger patients with morning stiffness that lasts more than 30 minutes and improves with activity.Dr. Arreaza:And of course, we always rule out cauda equina syndrome: a surgical emergency. That's urinary retention or incontinence, saddle anesthesia, bilateral leg weakness, or fecal incontinence. Missing this diagnosis can be catastrophic.Michael:Thankfully, in John's case, we don't see any red flags. His presentation is classic for uncomplicated lumbar radiculopathy. But we must stay vigilant, because sometimes patients don't offer up key symptoms unless we ask directly.Jordan:And that's where associated symptoms help guide us. For example:Radicular symptoms like numbness or weakness follow dermatomal patterns. Constitutional symptoms like fever or weight loss raise red flags. Bladder/bowel changes or saddle anesthesia raise alarms for cauda equina. Pain that wakes patients up at night might point to malignancy. Dr. Arreaza:So when do we order labs or imaging?Michael:Not right away. For most patients with acute low back pain, imaging is not needed unless they have red flags. If infection is suspected, we'd get CBC, ESR, and CRP. For cancer, maybe PSA or serum protein electrophoresis. And if inflammatory back disease is suspected, HLA-B27 can be helpful.Jordan:Yes, imaging should be delayed for at least six weeks unless red flags or significant neurologic deficits are present. When we do image, MRI is our go-to especially for suspected radiculopathy or cauda equina. X-rays can help if we're thinking about fractures, but they won't show soft tissue or nerve root issues.Michael:In the example from our case, since the patient doesn't have red flags, we'd go with conservative management: start NSAIDs and recommend activity modification. As this is the acute setting, physical therapy would not be recommended.Jordan:For the acute phase, research shows no serious difference between those with PT and those without in the long term. However, physical therapy is really the cornerstone of management for chronic back pain. It's not just movement: it's education, body mechanics, and teaching patients how to move safely. And PT can actually reduce opioid use, imaging, and injections down the line for patient struggling with long term back pain.Dr. Arreaza:Yes, and PT is not one-size-fits-all. PT might include McKenzie exercises, manual therapy, postural retraining, or even neuromuscular re-education. The goal is always to build core stability, promote healthy movement patterns, and reduce fear of motion.Jordan:Let's take a minute to talk about the McKenzie Method, a physical therapy approach used to treat lumbar disc herniation by identifying a specific movement, (often spinal extension) that reduces or centralizes pain. A common exercise is the prone press-up, (cobra pose for yoga fans) where the patient lies face down and pushes the upper body upward while keeping the hips on the floor to relieve pressure on the disc. These exercises should be done carefully, ideally under professional guidance, and discontinued if symptoms worsen.Michael:For our case patient, our working diagnosis is mechanical low back pain with L5 radiculopathy. No imaging needed now, no red flags. We'll treat conservatively and educate him about proper lifting, staying active, and recovery expectations.Jordan:We also emphasized to him that bed rest isn't helpful. In fact, bed rest can make things worse. Keeping active while avoiding heavy lifting for now is key.Dr. Arreaza:Return-to-work recommendations should be individualized. For example, an office worker, positioning while working, or work hours may be able to return to work promptly. However, those with physically demanding jobs may need light duty or be off work.Ice: no evidence of benefit. Heat: may reduce pain and disability in pain of less than 3 months, although the benefit was small and short.And we should always teach safe lifting techniques: bend at the knees, keep the load close, avoid twisting. It's basic knowledge, but it is very effective in preventing recurrence.Jordan:Now, if a patient fails to improve after 6 weeks of conservative therapy, or if they develop new neurologic deficits, that's when we think about referral to spine specialists or surgical consultation.Michael:And as previously mentioned: in cases where back pain becomes chronic (lasting more than 12 weeks) a multidisciplinary approach works best. That can include:Physical therapy, Cognitive behavioral therapy (CBT) And sometimes pain management interventions. Jordan:We can't forget the psychological toll either. Chronic back pain is associated with depression, anxiety, and opioid dependence. Increased risk factors include obesity, smoking, sedentary lifestyle, and previous back injuries.Dr. Arreaza:Well said. So, let's summarize. Michael?Michael:Sure! Low back pain is common, and most cases are benign. But we have to know the red flags that point to serious pathology. A focused history and physical exam are more powerful than many people realize. And the first step in treatment is almost always conservative, with a strong emphasis on maintaining physical activity.Jordan:And don't underestimate the value of patient education. Helping patients understand their pain, set realistic expectations, and stay active is often just as important as the medications or therapies we offer.Even without trying, every night you go to bed a little wiser. Thanks for listening to Rio Bravo qWeek Podcast. We want to hear from you, send us an email at RioBravoqWeek@clinicasierravista.org, or visit our website riobravofmrp.org/qweek. See you next week! _____________________References:Chou, R., Qaseem, A., Snow, V., Casey, D., Cross, J. T., Shekelle, P., & Owens, D. K. (2007). Diagnosis and treatment of low back pain: A joint clinical practice guideline from the American College of Physicians and the American Pain Society. Annals of Internal Medicine, 147(7), 478–491. https://doi.org/10.7326/0003-4819-147-7-200710020-00006Deyo, R. A., Mirza, S. K., Turner, J. A., & Martin, B. I. (2009). Overtreating chronic back pain: Time to back off? Journal of the American Board of Family Medicine, 22(1), 62–68. https://doi.org/10.3122/jabfm.2009.01.080102National Institute for Health and Care Excellence. (2020). Low back pain and sciatica in over 16s: Assessment and management (NICE Guideline No. NG59). https://www.nice.org.uk/guidance/ng59Qaseem, A., Wilt, T. J., McLean, R. M., & Forciea, M. A. (2017). Noninvasive treatments for acute, subacute, and chronic low back pain: A clinical practice guideline from the American College of Physicians. Annals of Internal Medicine, 166(7), 514–530. https://doi.org/10.7326/M16-2367UpToDate. (n.d.). Evaluation and treatment of low back pain in adults. Wolters Kluwer. https://www.uptodate.com (Access requires subscription)Theme song, Works All The Time by Dominik Schwarzer, YouTube ID: CUBDNERZU8HXUHBS, purchased from https://www.premiumbeat.com/. 

Dr. Jeff Ratliff talks with Dr. Brin E. Freund about the evaluated incidence and risk factors for acute symptomatic seizures during CAR T-cell therapy. Read the related article in Neurology®.  Disclosures can be found at Neurology.org. 

Join our free Facebook community at facebook.com/groups/witsandweights--Tired of the inflammation fear-mongering? Stop obsessing over "toxic" foods and learn what actually drives chronic inflammation in your body.While fitness influencers point fingers at gluten, seed oils, and nightshades, the real culprits are hiding in plain sight... and they're not what you think.This episode dismantles the myths surrounding inflammation and reveals the true drivers of this misunderstood health concern. While we're scrutinizing ingredient labels and avoiding specific foods, the actual causes of chronic inflammation are hiding in plain sight... and they have little to do with what's on your plate.Discover how to engineer an anti-inflammatory lifestyle using systems thinking instead of food perfectionism.Main Takeaways:Acute vs. chronic inflammation are completely different systems requiring different solutionsThe #1 driver of inflammation isn't foodsOne organ functions as your body's natural anti-inflammatory pharmacySpecific lifestyle factors matter more than eliminating specific foodsWestern dietary patterns drive inflammation, not individual ingredientsEpisode Resources:Try MacroFactor for free with code WITSANDWEIGHTS - Apple/iPhone or Google/AndroidTimestamps:0:00 - The inflammation myth 2:16 - Acute vs. chronic inflammation 3:39 - The real drivers of inflammation 5:31 - Why specific foods don't matter 8:42 - Engineering an anti-inflammatory lifestyle 12:13 - The anti-inflammatory organ you can develop 14:47 - Systems approach to inflammationSupport the show

Inflammation has become a nutrition buzzword, often used in extreme or misleading ways. This episode aims to clarify what inflammation is, how it relates to diet and health, and whether specific foods truly provoke inflammatory responses in the body. The episode provides a nuanced, evidence-based look at inflammation and diet. It explains the difference between acute and chronic inflammation, outlines the role of chronic low-grade inflammation in disease, and emphasizes that overall dietary patterns – rather than any single food – are what influence our inflammatory status. Commonly demonized foods (such as sugar, wheat, and dairy) are scrutinized, and the conversation debunks myths about them being uniformly “inflammatory.” In this episode, Danny takes a look at what the scientific evidence actually shows about anti-inflammatory diets. Note: This is a Premium-exclusive episode. Timestamps 01:06 Understanding Inflammation: Basics and Biomarkers 04:02 Acute vs. Chronic Inflammation 14:21 Biomarkers of Inflammation 22:51 Dietary Patterns and Inflammation 34:53 Specific Foods and Nutrients Impacting Inflammation 47:01 Practical Takeaways for an Anti-Inflammatory Diet 51:30 Conclusion Related Resources Subscribe to Sigma Nutrition Premium Enroll in the next cohort of our Applied Nutrition Literacy course Related podcast episodes: 329: Diet & Inflammation 353: James Hébert, ScD – Dietary Inflammatory Index Sigma Statement: Nutrition & Immune Function The Dietary Inflammatory Index (DII) – Hébert et al., 2019

Could physician advisors become dinosaurs in healthcare, bound for extinction?The role of the physician advisor has developed into an absolute necessity in hospitals of all sizes around the country. As the healthcare landscape rapidly evolves, physician advisors have served as critical players, bridging the gap between confusion and clarity within clinical and administrative functions.Yet, the question remains unanswered: why are only a fraction of physician advisors employed as full-time employees?During the next live edition of Talk Ten Tuesdays, Juliet B. Ugarte Hopkins, MD, Medical Director of Phoenix Medical Management, Inc., will report on the pitfalls of inadvertently diluting the physician advisor's focus and level of expertise.The popular Internet broadcast will feature the additional following instantly recognizable panelists, who will report more news during their segments:• CDI Report: Cheryl Ericson, Director of clinical documentation integrity (CDI) for the vaunted Brundage Group, will have the latest CDI updates;• The Coding Report: Christine Geiger, Assistant Vice President of Acute and Post-Acute Coding Services for First Class Solutions, will report on the latest coding news;• Field Report: Dennis Jones, a veteran Monitor Mondays and Talk Ten Tuesdays contributing editor, will report on the latest developments regarding the revenue cycle. Jones is the senior director of revenue cycle at Jefferson Health;• News Desk: Timothy Powell, ICD10monitor national correspondent, will anchor the Talk Ten Tuesdays News Desk; and• Point of View: Dr. Kennedy will report on his efforts to advocate for a change in the definition of sepsis. Dr. Kennedy will be sitting in for Angela Comfort, who continues as the co-host for the long-running and popular weekly Internet broadcast.

A new report says the MidWest will need another emergency department and 600 more acute hospital beds by 2040 to meet the demands of the growing population. It comes as The Friends of Ennis Hospital has published its latest research document covering hospital bed capacity projects for the next fifteen years. The group has recommended that a new hospital is built on a new campus and has also poured cold water on HSE plans to build a second 96 bed block at University Hospital Limerick, citing planning obstacles. Chairperson Angela Coll believes a Clare facility is the only viable solution.

In this episode of the RCP Medicine podcast, Professor Ailsa Hart and Dr Eathar Shakweh discuss how to approach managing Inflammatory Bowel Disease (IBD) in the acute medical setting. This is the first episode of a 2-part series, with a focus on ulcerative colitis.  IBD is a common condition, affecting 1 in 123 people in the UK. The 2024 State of the IBD Care in the UK report highlighted the urgent need to shorten time to diagnosis and initiate early treatment to minimise the risk of IBD-related complications. Acute and general medicine physicians have an important role to play in diagnosing and managing IBD. This podcast will equip medics at all stages of training with the necessary knowledge to approach this heterogenous and complex condition. Professor Hart is Director of IBD Research at St Mark's Hospital, London, United Kingdom and a world-leading expert in IBD. Eathar is an IBD Clinical Research Fellow at St Mark's and Imperial, with a special interest in perianal fistulising Crohn's disease. Crohn's & Colitis UK (CCUK) Websitehttps://crohnsandcolitis.org.uk/This is a valuable resource for patients and healthcare professionals alike, containing a wealth of information on IBD investigation and management.British Society of Gastroenterology (BSG) guidelines on Inflammatory Bowel Disease (IBD) - 2019Lamb, Christopher Andrew et al. “British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults.” Gut vol. 68,Suppl 3 (2019): s1-s106. doi:10.1136/gutjnl-2019-318484https://pubmed.ncbi.nlm.nih.gov/31562236/For interested listeners, these are the national guidelines for IBD diagnosis and management. Please note, the new guidelines for 2025 are pending release.RCP LinksEducation and learning | RCP Events | RCP Membership | RCP Improving care | RCP Policy and campaigns | RCP CreditsMusic by bensound.com

Tune in to this engaging VetFolio Voice podcast episode with host Dr. Cassi and her guest, Dr. Alison Manchester, to learn about clinically relevant information applicable to dietary management of GI upset, including recent updates—from clinical research to real-life cases—that are commonly seen in practice. The conversation encompasses a review of different dietary strategies, including their potential mechanisms of action. Special attention will be paid to the impact of diet and other interventions on the gut microbiome. You'll also explore the differences in dietary interventions for dogs and cats and get tips for client communication tactics that help maximize compliance.

Nederlandse scheepsbouwer Damen heeft grote financiële problemen - dat blijkt uit onderzoek van NRC. Doordat zes schepen, die gemaakt worden voor Duitsland, vertraging oplopen dreigt het bedrijf miljarden aan betalingen te laat binnen te krijgen. Hans van der Steeg gaat erover in gesprek met: - Carola Houtekamer, NRC-journalist - Jaime Karremann, van marineschepen.nl

This week, Richard Saville-Smith joins Kelly and John to talk about his book Acute Religious Experiences – Madness, Psychosis, and Religious Studies, which was published by Bloomsbury in 2023. Saville-Smith is an independent researcher who focuses on the intersection of madness, mental disorders, and acute religious experiences, from a mad studies perspective. He earned his PhD in Philosophy and Religious Studies from the University of Edinburgh in 2020. They discuss the relatively little-known academic field of mad studies - which seeks to destigmatize and depathologize the concept of madness - and how the fields of psychiatry and religious studies, often operating in conflict with one another, have distorted our understanding of the authenticity of acute religious experiences like the ones described in the lives of Joan of Arc or Jesus. Richard is on Bluesky @dranamorphosis

One of the largest regional coding organizations in America's healthcare universe – the California Health Information Association (CHIA) – wrapped its final workshops this past week, with delegates flying home to share their insights on what was considered to be a pivotal experience.The ICD10monitor producers of Talk Ten Tuesdays have secured a rare appearance of CHIA's past president, Gloryanne Byrant, who agreed to share five key takeaways from the annual conference.During the next live edition of Talk Ten Tuesdays, coming up at 10 a.m. EST on June 10, the popular Internet broadcast will feature the additional following instantly recognizable panelists, who will report more news during their segments:• CDI Report: Cheryl Ericson, Director of CDI for the vaunted Brundage Group, will have the latest CDI updates;• Field Report: Dennis Jones, a veteran Monitor Mondays and Talk Ten Tuesdays contributing editor, will report on the latest developments regarding the revenue cycle. Jones is the administrator of the revenue cycle at Jefferson Health;The Coding Report: Christine Geiger, Assistant Vice President of Acute and Post-Acute Coding Services for First Class Solutions, will report on the latest coding news;• News Desk: Timothy Powell, ICD10monitor national correspondent, will anchor the Talk Ten Tuesdays News Desk; and• MyTalk: Angela Comfort, veteran healthcare subject-matter expert, will co-host the long-running and popular weekly Internet broadcast. Comfort is the Assistant Vice President of Revenue Integrity for Montefiore Health.

Commentary by Dr. Jian'an Wang.

Commentary by Dr. Meixiang Xiang.

In this episode of the Rocket Chiro Podcast, Jerry Kennedy explores how different age groups engage with brands online—and what that means for your chiropractic marketing. Using a recent infographic from NP Digital as a jumping-off point, Jerry breaks down why Gen Z takes longer to follow brands on social media, why Boomers tend to move quicker, and how your marketing strategy should align with your goals, target demographic, and level of urgency. Whether you're doing content marketing, social ads, SEO, or community outreach, understanding your audience's behavior is crucial. Jerry also shares actionable strategies based on patient intent—like how to attract people looking for acute care now versus those slowly building trust over time. Key Takeaways 1. Different Generations = Different Timelines Gen Z needs an average of 11 exposures before following a brand. Millennials and Gen X fall in the 6–7 range—similar to long-standing marketing wisdom. Boomers need only 3 exposures on average. The more content someone consumes, the more desensitized they become—especially Gen Z. 2. Trust and Time in Marketing Most people don't take action the first time they see you unless they're in a crisis or acute pain. Content overload and algorithm filters mean you're competing with everything—not just other chiropractors. Patience is essential in relationship-based marketing. 3. Match Your Marketing to Your Intentions If you need patients today, prioritize: Acute care marketing SEO and Google Ads Networking with professionals If you're building a long-term brand, focus on: Content marketing (blogs, videos, podcasting, community involvement) Authority building (testimonials, reviews, collaborations) Social media presence (but know it takes time!) 4. Tailor Your Tactics by Demographic Older patients: Use Facebook, email, direct mail, print, TV, radio. Younger patients: Use Instagram, TikTok, YouTube Shorts, influencer collaborations. 5. Don't Fish in the Wrong Pond Align your: Target audience Marketing platform Message and tone Budget and expectations Actionable Tips for Chiropractors Need patients fast? Prioritize acute care, SEO, and local Google Ads. Targeting Gen Z or Millennials? Use short-form content, influencer partnerships, and be consistent with social media. Want trust over time? Focus on storytelling, authority, and being visible both online and offline. Don't fake it. Be genuine and let your personality come through in your content. Adapt. Stay aware of platform changes and be ready to evolve your strategy. Final Thoughts “Marketing isn't magic—it's a process. And if you're marketing to people who take longer to trust you, you have to be patient, intentional, and consistent. If your expectations and execution don't match, you're just wasting time and money.” Work With Jerry Want help with your website, SEO, or want to get unstuck in your practice? Visit RocketChiro.com and request a Free New Patient Search Review or explore the Next Step Program for on-demand chiropractic coaching. Want Help Growing Your Practice? Jerry offers business coaching, website design, SEO, and Google Ads services specifically for chiropractors. If you're ready for less stress and more momentum, visit RocketChiro.com. Free New Patient Search Review: https://rocketchiro.com/chiropractic-practice-assessment Best chiropractic websites: https://rocketchiro.com/best-chiropractic-websites Chiropractic SEO: https://rocketchiro.com/chiropractic-seo Coaching for Chiropractors: https://rocketchiro.com/join

Today's guests are Keisha Downes, MBA-HM, BSN, RN, CCDS, CCS, the vice president of middle revenue cycle for Beth Israel Lahey Health, based in Massachusetts, and Okemena Ewoterai, RN, BSN, MA, CCDS, CDIP, CCS, the director of CDI at Montefiore Medical Center in Bronx, New York. Today's show is part of the “Conversations with Karla” series, hosted by ACDIS Editorial Manager, Products and Events, Karla Kozak, and is part of the occasional series featuring members of the ACDIS Advisory Board. Our intro and outro music for the ACDIS Podcast is “medianoche” by Dee Yan-Kay and our ad music is “Take Me Higher” by Jahzzar, both obtained from the Free Music Archive. Have questions about today's show or ideas for a future episode? Contact the ACDIS team at info@acdis.org. Want to submit a question for a future "listener questions" episode? Fill out this brief form!  CEU info: Each ACDIS Podcast episode now offers 0.5 ACDIS CEU which can be used toward recertifying your CCDS or CCDS-O credential for those who listen to the show in the first two days from the time of publication. To receive your 0.5 CEU, go to the show page on acdis.org, by clicking on the “ACDIS Podcast” link located under the “Free Resources” tab. To take the evaluation, click the most recent episode from the list on the podcast homepage, view the podcast recording at the bottom of that show page, and click the live link at the very end after the music has ended. Your certificate will be automatically emailed to you upon submitting the brief evaluation. (Note: If you are listening via a podcast app, click this link to go directly to the show page on acdis.org: https://acdis.org/acdis-podcast/advisory-board-series-acute-skin-failure) Note: To ensure your certificate reaches you and does not get trapped in your organization's spam filters, please use a personal email address when completing the CEU evaluation form. The cut-off for today's episode CEU is Friday, June 6, at 11:00 p.m. eastern. After that point, the CEU period will close, and you will not be eligible for the 0.5 CEU for this week's episode. Today's sponsor: Today's show is brought to you by Pediatric CDI Foundations, previously titled Pediatric CDI: Building Blocks for Success. Click here to learn more and order your copy today! (https://bit.ly/3PEf7hK) ACDIS update: Apply to speak at the 2026 ACDIS conference by July 21! (https://bit.ly/3Z9zfOf) Get suggestions for session topics at the 2026 ACDIS conference! (https://bit.ly/42WIBiu) Apply to serve on an ACDIS committee by June 30! (https://www.surveymonkey.com/r/June-2025-ACDIS-committees)

In this episode, we break down the essential tools and strategies for managing acute Vestibular Migraine attacks. Whether you're newly diagnosed or a seasoned vestibular warrior, understanding your options can make all the difference in navigating sudden flares. We'll cover:

JACC's June 10 issue, focusing on the ACS guideline, features a series of videos with unique perspectives. In this video, JACC: Executive Associate Editor Karthik Murugiah, MBBS, MHS, FACC, introduces his paper discussing the guideline's reliance on four landmark RCTs in AMI-CS. Several sweeping changes in recommendations for MCS use have been codified that should influence practice and improve care for these high-risk patients. While IABP use is expected to decrease, use of mAFP is likely to increase but should be judicious, with caution against overgeneralizing given the narrow selection criteria of DanGer Shock. Evaluating real-world practice patterns and outcomes of patients with AMI-CS based on these recommendations will be paramount.

The national conference of the largest regional coding organization chapters in America's healthcare universe gets underway this weekend – and James S. Kennedy, MD, will be there.Dr. Kennedy, president of CDIMD, a national coding and clinical documentation integrity (CDI) consultancy, will be reporting on major events taking place at the California Health Information Association (CHIA) conference, starting this weekend in Southern California.As a longtime editorial contributor to RACmonitor and ICD10monitor, Dr. Kennedy, will be the special guest during the next live edition of Talk Ten Tuesdays, coming up at 10 a.m. EST on June 3. The Internet broadcast, produced by ICD10monitor, is expected to feature the additional following instantly recognizable panelists, who will report more news during their segments:•Social Determinants of Health: Tiffany Ferguson, CEO for Phoenix Medical Management, Inc., will report on the news that is happening at the intersection of medical record auditing and the SDoH;•CDI Report: Cheryl Ericson, Director of CDI for the vaunted Brundage Group, will have the latest CDI updates;•The Coding Report: Christine Geiger, Assistant Vice President of Acute and Post-Acute Coding Services for First Class Solutions, will report on the latest coding news;•News Desk: Timothy Powell, ICD10monitor national correspondent, will anchor the Talk Ten Tuesdays News Desk; and•MyTalk: Angela Comfort, veteran healthcare subject-matter expert, will co-host the long-running and popular weekly Internet broadcast. Comfort is the Assistant Vice President of Revenue Integrity for Montefiore Health.

Show notes at pharmacyjoe.com/episode1031. In this episode, I'll discuss expectations for the onset of action of IM medications used for acute agitation. The post 1031: How Long Does it Take for IM Medications to Work in Acute Agitation? appeared first on Pharmacy Joe.

This sermon was preached on June 1, 2025 at Antioch Presbyterian Church, a congregation of Calvary Presbytery of the Presbyterian Church in America located in Woodruff, South Carolina. Pastor Zachary Groff preached this sermon entitled "Acute Affliction" on Exodus 5:1 – 6:13. For more information about Antioch Presbyterian Church, please visit ⁠antiochpca.com⁠ or contact us at ⁠⁠info@antiochpca.com.

En dat is misschien een verrassing als je naar de huidige cijfers kijkt. Die blijven bizar goed. Beleggers hebben moeite om er negatieve punten in te vinden. Maar dat hoeven ze ook niet, want topman Jensen Huang licht ze er zelf even uit. Hij heeft wederom kritiek op het Witte Huis. Met hun exportrestricties levert de VS hem een min van 8 miljard dollar op zijn kwartaalrekening op. Maar hij lijkt nog steeds niet helemaal eerlijk. De impact van Trump kan nog veel groter zijn dan de topman nu beweert. Daarnaast hoor je ook wat je gemist hebt in de handelsoorlog de afgelopen dagen. Een dag niet opletten betekent namelijk meteen een hele hoop ontwikkelingen missen. Zoals de rechter die een streep door zo ongeveer alle importheffingen zet. En vervolgens ook weer de melding dat er een streep door die streep gaat zolang het hoger beroep loopt. Dan zijn er ook nog die gesprekken met China. Die verlopen niet stroef, maar staan zelfs 'een beetje vast', zegt Financiënminister Scott Bessent. Het is nodig dat de presidenten persoonlijk met elkaar gaan praten. Maar of ze dat ook echt gaan doen, dat blijft de vraag. En verder vertellen we je over het onderonsje tussen Donald Trump en Jerome Powell. Die zou niet heel vriendschappelijk zijn verlopen. Trump vindt dat Powell een fout maakt doordat hij de rente niet verlaagt. En Powell zou een poging hebben gedaan om z'n acties uit te leggen.See omnystudio.com/listener for privacy information.

In this episode, we review the high-yield topic Acute Hepatitis ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠from the Gastrointestinal section at ⁠⁠⁠⁠Medbullets.com⁠⁠⁠⁠⁠⁠Follow⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Medbullets⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbulletsLinkedin: https://www.linkedin.com/company/medbullets

Michael S. Lloyd, MD, FHRS, Emory University is joined by Edward P. Gerstenfeld, MD, MS, FHRS, University of California, San Francisco, and Christopher C Cheung, MD, MPH, FHRS, Sunnybrook HSC, University of Toronto, to discuss the VOLT-AF IDE study evaluated the safety and effectiveness of a novel balloon-based pulsed field ablation (PFA) catheter system for treating paroxysmal and persistent atrial fibrillation (PAF and PsAF). Conducted at 34 global sites, the study enrolled 394 subjects, with 320 included in the primary analysis. Acute pulmonary vein isolation (PVI) success was achieved in over 99% of veins, and primary serious adverse events occurred in only 1.9% of patients, with no significant complications like esophageal injury or hemolysis. Procedure metrics showed efficient operation times, and early 6-month data suggest promising effectiveness. These initial findings support the Volt™ PFA system as a safe and effective treatment option for AF.    https://www.hrsonline.org/education/TheLead https://www.heartrhythmjournal.com/article/S1547-5271(25)02168-X/fulltext Host Disclosure(s): M. Lloyd: Honoraria/Speaking/Consulting: Medtronic, Arga Medtech, Circa Scientific Membership on Advisory Committees: Boston Scientific Contributor Disclosure(s):   E. Gerstenfeld: Honoraria/Speaking/Consulting: Medtronic, Boston Scientific, Biosense Webster, Abbott, Varian Medical Systems, Biotronik Other Non-Financial Relationships: Farapulse, Adagio Medical, Boston Scientific, Abbott Medical, Research (Contracted Grants for PIs and Named Investigators only): Abbott Medical Officer, Trustee, Director, Committee Chair, or Any Other Fiduciary Role: American College of Cardiology Foundation C. Cheung: Nothing to disclose.

Circulation 1999;100:2312-2318Background: The CONSENSUS and SOLVD trials established the effectiveness of angiotensin converting enzyme inhibitors (ACEi) in reducing mortality and morbidity in patients with systolic heart failure. Both trials used enalapril with a target dose of 20mg twice a day (max dose) in the CONSENSUS trial and 10mg twice a day (medium dose) in the SOLVD trials. In real-world settings, ACEi are sometimes prescribed at lower doses, likely reflecting concerns about adverse effects or patients' tolerance. It was unclear whether the benefit from low doses of ACEi is comparable to high doses.Cardiology Trial's Substack is a reader-supported publication. To receive new posts and support our work, consider becoming a free or paid subscriber.The Assessment of Treatment with Lisinopril and Survival (ATLAS) trial sought to assess the efficacy and safety of low vs high doses of ACE inhibition in patients with systolic heart failure.Patients: Eligible patients had left ventricular ejection fraction of 30% or less and had NYHA class II, III or IV despite treatment with diuretics for two or more months.Patients were excluded if they had any of the following: Acute coronary syndrome or revascularization procedure within 2 months, history of sustained or symptomatic ventricular tachycardia, known intolerance to ACEi, serum creatinine >2.5 mg/dL, or any noncardiac condition that could limit survival.Baseline characteristics: The trial randomized 3,164 patients – 1,596 randomized to the low-dose arm and 1,568 to the high dose arm.The average age of patients was 64 years and 80% were men. The average left ventricular ejection fraction was 23%. Cardiomyopathy was ischemic in 65% of the patients. The NYHA class was II in 16% of the patients, III in 77% and IV in 7%.Data on baseline comorbid conditions were not provided in the main manuscript.Procedures: The study was double blinded. At the beginning of the study, all patients received open-label lisinopril for four weeks to assess who is able to tolerate the drug. Patients who were able to tolerate lisinopril 12.5 mg to15 mg daily for two or more weeks were randomized in a 1:1 ratio to receive low-dose or high-dose ACEi. The target dose of lisinopril in the lose dose group was 2.5 to 5.0mg daily and was 32.5 to 35mg daily in the high dose group.All patients received open-label lisinopril 2.5 to 5mg daily. This dose was selected by the investigator. In addition, patients received up to three 10mg tablets of lisinopril or matching placebo.Endpoints: The primary endpoint was all-cause mortality. Secondary end points included cardiovascular mortality, all-cause hospitalization and cardiovascular hospitalizations.Analysis was performed based on the intention-to-treat principle. The estimated sample size was 3,000 patients. This sample size had 90% power at 5% alpha to detect 15% relative risk difference in the mortality between both treatment groups assuming 19% 1-year mortality in the high dose group.Results: Of the 3,793 patients who entered the initial open-label tolerability phase, 83.4% were randomized. A total of 176/3,793 (4.6%) were withdrawn for possible side effects. The median follow-up time was 46 months.Target doses were achieved in 92.7% of the patients in the low-dose group and 91.3% in the high-dose group. Study medication was discontinued by 30.6% of patients in the low-dose group and 27.2% in the high-dose group.All-cause mortality was not significantly different between both treatment groups (44.9% with low dose vs 42.5% with high dose, HR: 0.92, 95% CI: 0.82 – 1.03; p= 0.128). Cardiovascular mortality was numerically lower in the high dose group but this was not statistically significant (37.2% vs 40.2%, HR: 0.90, 95% CI: 0.81 – 1.01; p= 0.073). All-cause hospitalization was lower in the high dose group (3,819 hospitalizations vs 4,397; p= 0.021). Hospitalizations for cardiac causes and hospitalizations for heart failure were also lower in the high dose group (2,456 vs 2,923; p= 0.05) and (1,199 vs 1,576; p= 0.002), respectively.Patients in the high-dose group experienced more dizziness (19% vs 12%), more hypotension (11% vs 7%), more worsening renal function (10% vs 7%), and more hyperkalemia (6% vs 4%), but reported less cough (11% vs 13%) and had less hypokalemia (1% vs 3%).There were no significant subgroup interactions for the primary outcome.Conclusion: In patients with systolic heart failure, high dose ACE inhibition did not significantly reduce mortality compared to low-dose but it led to significantly less hospitalizations. In this trial of 3,164 patients and with a median follow up of 46 months, there were 578 less hospitalizations in the high dose group.Based on these results, we recommend up-titrating ACEi and use higher doses if tolerated. Although, side effects were more common in the high dose group, these can generally be managed with reducing the dose in the outpatient settings.Cardiology Trial's Substack is a reader-supported publication. To receive new posts and support our work, consider becoming a free or paid subscriber. Get full access to Cardiology Trial's Substack at cardiologytrials.substack.com/subscribe

Ever wonder how chronic pain impacts not just your body, but your mindset and life? This week I'm joined by Dr. Amber Johnston, a leading Clinical Psychologist and Neuropsychologist, to unpack the science behind pain. We talk about breaking the cycle of fear and avoidance, how stress amplifies pain, and practical steps to reclaim your life. Whether you're battling pain or supporting someone who is, you'll gain actionable strategies to feel empowered and hopeful again. Listen in and discover how changing your relationship with pain can change everything.Highlights include:04:13 Acute vs. Chronic Pain08:26 Chronic Pain's Impact on Social Plans11:36 Subjectivity of Pain Perception15:49 Brain's Complex Pain Processing18:59 Perception's Role in Chronic Pain22:10 Understanding Fear Avoidance Cycle25:21 Rethinking Pain Signals30:18 Impact of Lifestyle on HealthWant more?Head over to Hello Therapy's Substack for an EXCLUSIVE mini interview where I ask Dr Amber why she specialised in pain and what her personal, go-to pain management strategy is. Watch HERE.This week's guest:Dr Amber Johnston, a practicing clinician specialising in Clinical, Health, Pain Management, and Neuropsychology, offers her expertise to individuals facing a broad spectrum of challenges - from those with mild stress looking to build healthier emotional tools, to those with more significant clinical diagnoses that need formal, specialised treatment. Amber also works with individuals who do not meet clear psychological or medical diagnosis, those requiring cognitive assessment or emotional support following a neurological injury or stroke, those with complex chronic medical conditions, and those with medically unexplained symptoms/Functional Neurological Disorder including health anxiety. In her capacity as the founder and director of Healthy Mind Psychology, Amber leads a team of over 26 doctoral-level Psychologists. Her mission is to expand understanding of the mind/body connection and emphasise the important message that psychological understanding is important for everybody.Follow Amber:@healthymindpsychologyukLinkedInBE PART OF OUR GROWING SUBSTACK COMMUNITY FOR FREE - Join now****************For private psychology services and therapy in person (London/Hertfordshire) or online, please visit Harley Clinical Psychology.*****************Subscribe to Dr Liz's YouTube channelFollow Harley Clinical on InstagramFollow Dr Liz White on TikTok*****************DISCLAIMER - The Hello Therapy podcast and the information provided by Dr Liz White (DClinPsy, CPsychol, AFBPsS, CSci, HCPC reg.), is solely intended for informational and educational purposes and does not constitute personalised advice. Please reach out to your GP or a mental health professional if you need support.

Following almost three months of a complete blockade to aid in Gaza, the entire population is facing a severe risk of famine. Acute malnutrition is increasing among the starving children in the enclave. Every hour counts. UNICEF Spokesperson James Elder describes the worsening situation in Gaza.

In this episode of the Epigenetics Podcast, we talked with Ani Deshpande from Sanford Burnham Prebys about his work on epigenetic regulation and developing small molecules through high throughput screens for AML. Throughout our discussion, we delve into Dr. Despande's journey into the field of biology and science, tracing his evolution from a literature enthusiast in Mumbai to a dedicated cancer researcher. He reflects on his formative experiences during his PhD at Ludwig Maximilian University in Munich, where she developed murine models for refractory acute myeloid leukemia (AML). We examine these models' contributions to therapeutic discovery and understanding the intricate mechanisms underscoring AML's complexities. Transitioning to his postdoctoral work at Scott Armstrong's lab in Boston, Dr. Despande shares his insights on the importance of epigenetic regulators, such as DOT1L, in leukemias, and how they can serve as strategic therapeutic targets. His ambitious pursuit of translational research is further highlighted through his efforts in developing a conditional knockout mouse model and his collaborative work utilizing CRISPR technology to refine our understanding of epigenetic regulation in cancer pathogenesis. Moreover, we engage in a conversation about the challenges and opportunities that arise when establishing his lab at Sanford Burnham Prebys. Dr. Despande candidly discusses the delicate balance between pursuing topics of genuine interest versus adhering to grant fundability, underlining the tension researchers face in the current scientific landscape. His emphasis on the critical need for innovation within lab settings serves as a motivational call for emerging scientists to venture beyond the established templates that often inhibit groundbreaking discoveries. We conclude our dialogue with an exploration of his recent projects, which involve targeting specific epigenetic modifiers and how his lab's findings can contribute to greater understanding and potential treatments for not only AML but also other pediatric cancers driven by gene fusions. Dr. Despande's insights into the integration of modern technologies, such as CRISPR libraries, exemplify his commitment to pushing the boundaries of cancer research. In addition to discussing his scientific contributions, we touch upon Dr. Despande's foray into podcasting (The Discovery Dialogues), shedding light on his motivation to bridge the communication gap between scientists and the broader public. He articulates his desire to demystify scientific discoveries and promote awareness about the intricate journey of research that lays the groundwork for medical advancements. This multidimensional discussion not only highlights his scientific achievements but also emphasizes the importance of effective science communication in fostering public understanding and appreciation of research.   References Deshpande AJ, Cusan M, Rawat VP, Reuter H, Krause A, Pott C, Quintanilla-Martinez L, Kakadia P, Kuchenbauer F, Ahmed F, Delabesse E, Hahn M, Lichter P, Kneba M, Hiddemann W, Macintyre E, Mecucci C, Ludwig WD, Humphries RK, Bohlander SK, Feuring-Buske M, Buske C. Acute myeloid leukemia is propagated by a leukemic stem cell with lymphoid characteristics in a mouse model of CALM/AF10-positive leukemia. Cancer Cell. 2006 Nov;10(5):363-74. doi: 10.1016/j.ccr.2006.08.023. PMID: 17097559. Deshpande AJ, Deshpande A, Sinha AU, Chen L, Chang J, Cihan A, Fazio M, Chen CW, Zhu N, Koche R, Dzhekieva L, Ibáñez G, Dias S, Banka D, Krivtsov A, Luo M, Roeder RG, Bradner JE, Bernt KM, Armstrong SA. AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes. Cancer Cell. 2014 Dec 8;26(6):896-908. doi: 10.1016/j.ccell.2014.10.009. Epub 2014 Nov 20. PMID: 25464900; PMCID: PMC4291116. Sinha S, Barbosa K, Cheng K, Leiserson MDM, Jain P, Deshpande A, Wilson DM 3rd, Ryan BM, Luo J, Ronai ZA, Lee JS, Deshpande AJ, Ruppin E. A systematic genome-wide mapping of oncogenic mutation selection during CRISPR-Cas9 genome editing. Nat Commun. 2021 Nov 11;12(1):6512. doi: 10.1038/s41467-021-26788-6. Erratum in: Nat Commun. 2022 May 16;13(1):2828. doi: 10.1038/s41467-022-30475-5. PMID: 34764240; PMCID: PMC8586238.   Related Episodes Targeting COMPASS to Cure Childhood Leukemia (Ali Shilatifard) The Menin-MLL Complex and Small Molecule Inhibitors (Yadira Soto-Feliciano) MLL Proteins in Mixed-Lineage Leukemia (Yali Dou)   Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com

In this enlightening conversation, Dr. Steiner discusses the complexities of bone vitality and the challenges associated with traditional bone grafting techniques. He emphasizes the limitations of cadaver and animal grafts, advocating for resorbable grafts that promote true bone regeneration. The discussion also highlights the importance of understanding inflammation in healing, the need for better education in dental training, and the growing acceptance of holistic approaches in dentistry. Dr. Steiner shares his journey in innovating bone grafting solutions and encourages dental professionals to question conventional practices for the benefit of their patients. Want to see more of The Holistic Dentistry Show? Watch our episodes on YouTube! Do you have a mouth- or body-related question for Dr. Sanda? Send her a message on Instagram! Remember, you're not healthy until your mouth is healthy. So take care of it in the most natural way.  Key Takeaways: (03:20) Dr. Steiner's Journey and Innovations (06:11) Understanding Bone Grafts and Their Limitations (09:03) The Science Behind Bone Induction (12:06) Challenges with Cadaver and Animal Grafts (15:19) The Importance of Resorbable Grafts (18:15) Acute vs. Chronic Inflammation in Healing (21:08) Immediate Implants and Grafting Techniques (24:08) Infection Risks and Antibiotic Use (27:07) Education Gaps in Bone Physiology (30:04) Navigating Resistance in the Dental Community (32:52) The Future of Bone Grafting and Holistic Dentistry (36:03) Final Thoughts and Educational Resources Guest Info Dr. Greg Steiner  Facebook: /bonegrafts OsNovum Facebook: /osnovum LinkedIn: /osnovum www.wefunder.com/osnovum Connect With Us:  AskDrSanda | YouTube BeverlyHillsDentalHealth.com | Instagram  DrSandaMoldovan.com | Instagram  Orasana.com | Instagram

In this week's episode we'll learn about how frequent blood donation affects clonal hematopoiesis in older, male blood donors; the effect of immune microenvironment on response to bispecific antibodies in diffuse large B-cell lymphoma; and the feasibility of adding blinatumomab to early consolidation therapy in CD19-positive Ph-negative B-cell acute lymphoblastic lymphoma.Featured ArticlesClonal Hematopoiesis Landscape in Frequent Blood DonorsIntegrative genomic analysis of DLBCL identifies immune environments associated with bispecific antibody responseUpfront Blinatumomab Improves MRD Clearance and Outcome in Adult Ph-negative B-lineage ALL: The GIMEMA LAL2317 Phase 2 Study

In this episode of Storycomic Presents, I sit down with Karoleen Fober—spiritual teacher, intuitive business and life coach, and author of Opening to Divine Intervention. With over two decades of experience, Karoleen has guided countless individuals on their spiritual journeys, helping them tap into their intuitive abilities and connect with Divine messages. We delve into her unique ACUTE system, the 15 types of Divine Intervention, and how these insights can transform personal and professional lives. Karoleen also shares her transition from early childhood educator and financial planner to a life dedicated to spiritual coaching and energy reading. Tune in for an enlightening conversation that bridges practical tools with profound spiritual insights. Learn More at: https://www.karoleenfober.com The Title sequence was designed and created by Morgan Quaid. See more of Morgan's Work at: https://morganquaid.com/   Storycomic Logo designed by Gregory Giordano See more of Greg's work at: https://www.instagram.com/gregory_c_giordano_art/   Want to start your own podcast?  Click on the link to get started: https://www.podbean.com/storycomic   Follow us: Are you curious to see the video version of this interview?  It's on our website too! www.storycomic.com www.patreon.com/storycomic www.facebook.com/storycomic1 https://www.instagram.com/storycomic/ https://twitter.com/storycomic1 For information on being a guest or curious to learn more about Storycomic? Contact us at info@storycomic.com   Thank you to our Founders Club Patrons, Michael Winn, Higgins802, Von Allan, Stephanie Nina Pitsirilos, Marek Bennett, Donna Carr Roberts, Andrew Gronosky, and Matt & Therese. Check out their fantastic work at: https://marekbennett.com/ https://www.hexapus-ink.com/ https://www.stephanieninapitsirilos.com/ https://www.vonallan.com/ https://higgins802.com/ https://shewstone.com/ https://mrfuzzyears.com/ Also to Michael Winn who is a member of our Founders Club!

In this episode of the RWS Clinician's Corner, Margaret sits down with Ashok Gupta for a deep dive into the brain's pivotal role in chronic illness—exploring how conditions like Long Covid, chronic fatigue syndrome, fibromyalgia, mold toxicity, and persistent inflammation can often be rooted in neural and nervous system dysregulation. They discuss the distinction between hardware (the body) and software (the brain and nervous system), the science and process of limbic retraining, and practical ways clinicians can integrate these approaches into their practices.   In this interview, we discuss:       -Brain retraining vs. meditation/stress reduction      -The concept of creating and rewiring neural pathways      -Acute vs. chronic illness: transition due to overactive protective responses      -The role of genetic predispositions (e.g., detox ability, immune differences)      -The three “R”s of brain retraining: regulate, retrain, re-engage       -Practical considerations for implementation, maintenance, and long-term success      -Strategies for integrating these techniques/the Gupta program in clinical practice The Clinician's Corner is brought to you by Restorative Wellness Solutions.  Follow us: https://www.instagram.com/restorativewellnesssolutions/   Connect with Dr. Ashok Gupta: Website: http://www.guptaprogram.com Instagram: https://www.instagram.com/guptaprogram/?hl=en Facebook: https://www.facebook.com/guptaprogram/   Special Offer to RWS Listeners:  We offer all practicing clinicians free access to our brain retraining program for one year -  worth $499 - they can sign up/apply at: https://guptaprogram.com/health-professionals/ Timestamps:    00:00 Mind-Body Healing Hypothesis 09:27 "Integrating Brain-Gut Axis Approaches" 12:59 "Brain Retraining for Chronic Issues" 18:18 Chronic Illness: Break the Vicious Cycle 26:26 Reengage with Joy Program 32:23 "Commit to a Healing Journey" 36:17 Acute vs. Chronic Treatment Approaches 43:50 "Brain Retraining Effectiveness Factors" 49:53 Brain Retraining for Clinicians 52:55 Clinician Co-Branding Service Launch 56:10 Incorporating Nervous System in Health 01:06:22 "Neuroplasticity Healing Success Stories" 01:10:42 Clinician's Corner: Episode Recap Speaker bio: Ashok is an internationally renowned Speaker, Filmmaker & Health Practitioner who has dedicated his life to supporting people through chronic illness, and achieving their potential.   Ashok suffered from ME, or Chronic Fatigue Syndrome, around 25 years ago when he was studying at Cambridge University. Through neurological research that he conducted, he managed to get himself 100% better. He then set up a clinic to treat others, and then published the well-known neuroplasticity “limbic retraining” recovery program and app known as the Gupta Program in 2007.    He has published several medical papers including randomized controlled trials on Long Covid, ME/CFS & Fibromyalgia, showing that the treatment is effective, and he is continually researching these conditions.   Keywords:  brain retraining, limbic retraining, neuroplasticity, chronic illness, chronic fatigue syndrome, ME/CFS, long Covid, fibromyalgia, mold toxicity, autoimmunity, gut health, nervous system regulation, functional medicine, integrative health, immune system, inflammation, trauma healing, stress reduction, somatic techniques, meditation, breath work, Gupta Program, functional health practitioners, clinical studies, pain management, anxiety, depression, food sensitivities, neuroscience, recovery   Disclaimer: The views expressed in the RWS Clinician's Corner series are those of the individual speakers and interviewees, and do not necessarily reflect the views of Restorative Wellness Solutions, LLC. Restorative Wellness Solutions, LLC does not specifically endorse or approve of any of the information or opinions expressed in the RWS Clinician's Corner series. The information and opinions expressed in the RWS Clinician's Corner series are for educational purposes only and should not be construed as medical advice. If you have any medical concerns, please consult with a qualified healthcare professional. Restorative Wellness Solutions, LLC is not liable for any damages or injuries that may result from the use of the information or opinions expressed in the RWS Clinician's Corner series. By viewing or listening to this information, you agree to hold Restorative Wellness Solutions, LLC harmless from any and all claims, demands, and causes of action arising out of or in connection with your participation. Thank you for your understanding.  

UnitedHealth Group (UHG) stock is plummeting following the abrupt resignation of its CEO Andrew Witty. His sudden departure, coming on Tuesday, May 13, came amid multiple lawsuits and threatened actions by private, state, and federal agencies across the country, and amid massive criticism for the company's tendency to deny beneficiaries coverage for services at elevated rates.Witty's exit from the giant payer – a long-time dominant force related to revenue cycle, provider staffing, utilization, and managed and commercial health insurance plans – seems to have rattled many in America's sprawling health delivery system. So, how could these recent events affect other hospitals and health systems?During the next live edition of the popular Talk Ten Tuesdays, the Internet broadcast produced by ICD10monitor, Dr. Juliet Ugarte Hopkins will share what she thinks of what might lie ahead. Dr. Ugarte Hopkins is the medical director for Phoenix Medical Management, Inc. and the Immediate Past President of the American College of Physician Advisors.Also part of the live broadcast will be these instantly recognizable panelists, who will report more news during their segments:• Social Determinants of Health: Tiffany Ferguson, CEO for Phoenix Medical Management, Inc., will report on the news that is happening at the intersection of medical record auditing and the SDoH;• CDI Report: Cheryl Ericson, Director of Clinical Documentation Integrity (CDI) for the vaunted Brundage Group, will have the latest CDI updates;• The Coding Report: Christine Geiger, Assistant Vice President of Acute and Post-Acute Coding Services for First Class Solutions, will report on the latest coding news;• News Desk: Timothy Powell, ICD10monitor national correspondent, will anchor the Talk Ten Tuesdays News Desk; and• MyTalk: Angela Comfort, veteran healthcare subject-matter expert, will co-host the long-running and popular weekly Internet broadcast. Comfort is the Assistant Vice President of Revenue Integrity for Montefiore Health.

Welcome to Season 2 of the Orthobullets Podcast. Today's show is Coinflips, where expert speakers discuss grey zone decisions in orthopedic surgery. This episode will feature doctors Jonathan Yerasimides, Neil Sheth, & Aldo Riesgo. They will discuss the case titled "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Acute Hip Pain s/p Bilateral THA in 79M⁠.⁠⁠⁠⁠⁠⁠" Follow ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Orthobullets⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ on Social Media:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Facebook⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Instagram⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Twitter⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Linkedln⁠

Oregon kindergarteners are opting out of vaccinations at increasingly higher rates over the last four years. And public health officials are growing increasingly concerned. Oregon is one of just 15 states that allow parents to opt out of childhood vaccinations for nonreligious, nonmedical reasons. The current opt-out rate of 9.7% is the highest recorded in state history. Health officials say the measles and pertussis outbreaks in the state are an indication more work is needed to boost vaccination rates more broadly.We get more details from Stacy de Assis Matthews, the immunization coordinator at Oregon Health Authority, and Dr. Paul Cieslak, medical director for the Acute and Communicable Disease Prevention Section and the Oregon Immunization Program at OHA.      

To have your question featured in a future video, please email: questions@morses.tv Please include at least: Age, Weight and as much history as possible.

Radiology reports are rich in clinical detail, yet ICD-10 codes often fail to fully capture the complexity and specificity of imaging findings.That is why the producers of Talk Ten Tuesdays and ICD10monitor have invited Laura Manser to explore the most common disconnects between radiology documentation and ICD-10 coding – especially in areas like incidental findings, laterality, and linking imaging results to medical necessity.During the next edition of the weekly broadcast, Manser is also expected to highlight common errors, such as coding suggestive findings as definitive diagnoses, and provide practical guidance on bridging the gap between documentation and compliance.Also part of the live broadcast will be these instantly recognizable panelists, who will report more news during their segments:• Social Determinants of Health: Tiffany Ferguson, CEO for Phoenix Medical Management, Inc., will report on the news that is happening at the intersection of medical record auditing and the SDoH.• The Coding Report: Christine Geiger, Assistant Vice President of Acute and Post-Acute Coding Services for First Class Solutions, will report on the latest coding news.• News Desk: Timothy Powell, ICD10monitor national correspondent, will anchor the Talk Ten Tuesdays News Desk.• MyTalk: Angela Comfort, veteran healthcare subject-matter expert, will co-host the long-running and popular weekly Internet broadcast. Comfort is the Assistant Vice President of Revenue Integrity for Montefiore Health.

This episode delves into one of the most pertinent topics for today's practitioners—the efficacy and safety of spinal adjustments for managing acute neck pain—based on a newly published systematic review and meta-analysis in 2025. This research strongly supports the use of spinal adjustments as a first-line treatment for acute neck pain, providing both pain relief and restored function safely and effectively. Plus, that's a compelling message to share with your patients on social and in your local healthcare networks.Episode Notes: Efficacy and safety of spinal manipulative therapy in the management of acute neck pain: a systematic review and meta-analysisThe Best Objective Assessment of the Cervical Spine- Provide reliable assessments and exercises for Neuromuscular Control, Proprioception, Range of Motion, and Sensorimotor-Integration. Learn more at NeckCare.comTurncloud EHR- Minimalist design, without being sparse. Practical, yet elegant. Turncloud's design was to find the most efficient path in a day in the life of a chiropractic office. Connect with their team at www.turncloud.com Patient Pilot by The Smart Chiropractor is the fastest, easiest to generate weekly patient reactivations on autopilot…without spending any money on advertising. Click here to schedule a call with our team.Our members use research to GROW their practice. Are you interested in increasing your referrals? Discover the best chiropractic marketing you aren't currently using right here!

In this episode of the PFC Podcast, Ian Wedmore, an expert in high altitude medicine, discusses the newly released Clinical Practice Guidelines (CPG) for altitude-related illnesses. The conversation covers the pathophysiology of acute mountain sickness, high altitude pulmonary edema, and high altitude cerebral edema, as well as their diagnosis and treatment protocols. Ian emphasizes the importance of understanding the symptoms, utilizing technology, and implementing prevention strategies to effectively manage altitude illnesses in military and wilderness settings.TakeawaysThe new CPG for altitude medicine is a significant advancement.Acute mountain sickness occurs when the body ascends too quickly without acclimatization.Diagnosis of altitude sickness relies heavily on symptom scoring systems.Vital signs are crucial for diagnosing high altitude pulmonary edema.Dexamethasone is essential for treating high altitude cerebral edema.Pre-exposure prophylaxis can reduce the risk of altitude sickness.Acetazolamide is the primary medication for preventing acute mountain sickness.Understanding the pathophysiology of altitude illnesses is key for treatment.Good hydration and nutrition are critical for acclimatization.Data collection through medic encounter forms will improve altitude care.Chapters00:00 Introduction to High Altitude Medicine02:51 Understanding Acute Mountain Sickness06:13 Diagnosing and Differentiating Altitude Illnesses08:56 Pathophysiology of High Altitude Pulmonary and Cerebral Edema12:04 Treatment Protocols for Altitude Illnesses15:08 Utilizing Technology in Altitude Medicine18:00 Prevention and Prophylaxis Strategies20:45 The Role of Medications in Altitude Care24:13 Future Directions in Altitude Medicine27:01 Conclusion and Key TakeawaysLink to full podcast:⁠https://creators.spotify.com/pod/show/dennis3211/episodes/Prolonged-Field-Care-Podcast-228-DImE-e32aek2⁠Thank you to Delta Development Team for in part, sponsoring this podcast.⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠deltadevteam.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠For more content, go to ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.prolongedfieldcare.org⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Consider supporting us: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠patreon.com/ProlongedFieldCareCollective⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ or ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.lobocoffeeco.com/product-page/prolonged-field-care⁠⁠

Episode Summary: In this episode, Dr. Ali Novitsky — expert in obesity medicine — explores the powerful link between stress and hunger. While many recognize stress affects eating, Dr. Novitsky explains the underlying science, behavioral patterns, and offers tools to manage stress-driven eating with compassion.Understanding Stress ResponsesDr. Novitsky explains that responses to stress vary widely. Some lose their appetite during stress, while others overeat. This depends on physiology, past experiences, and genetics. It's not about willpower; it's about biology and behavior.The Role of HormonesAdrenaline (acute stress): Suppresses hunger during “fight or flight” by slowing digestion.Cortisol (chronic stress): Increases appetite and cravings, especially for sugar and fat.Ghrelin: The “hunger hormone,” rises with stress, intensifying hunger cues.Leptin: The “fullness hormone,” can be blunted by chronic stress, leading to overeating.Acute vs. Chronic StressShort-term stress may shut down appetite. Chronic stress, however, causes lasting hormonal shifts that increase hunger, slow metabolism, and may cause leptin resistance. Dr. Novitsky explains how chronic stress and dieting can disrupt satiety signals and lead to weight challenge — even in those with a “normal” BMI.Behavioral & Genetic ComponentsCoping with food often starts in childhood. Learned behaviors and genetic predispositions influence whether one turns to food under stress. Dr. Novitsky shares her personal experience using food for emotional comfort, highlighting the importance of empathy over shame.Tools to Navigate Stress EatingSomatic Stress Scale (1–10) from DBT helps identify rising stress before acting on it.Mindful Pauses: Ask, “Am I hungry or triggered?”Compassionate Self-Talk: Replace guilt with curiosity.Nourishing Alternatives: Movement, breathwork, journaling, or support.Regulate First: Focus on emotional regulation before dietary restriction.Key InsightManaging stress is a foundation for managing hunger. When we understand our body's signals and respond with awareness and kindness, we create sustainable habits. Dr. Novitsky reminds us we're human, not broken—and we're in this together.Final ThoughtThere's no shame in stress eating. With knowledge, tools, and compassion, we can make empowered, healthier choices. Dr. Novitsky signs off with gratitude and love.Timestamps00:00:22 - Overview of Stress and Hunger00:00:52 - Individual Responses to Stress00:01:25 - Genetics and Stress Response00:01:46 - Acute vs. Chronic Stress00:02:06 - Hormones Involved in Stress Response00:02:28 - Adrenaline and Acute Stress00:03:43 - Cortisol and Chronic Stress00:05:00 - Insulin and Blood Sugar00:05:20 - Ghrelin and Hunger00:06:13 - Weight Loss and Stress00:06:47 - Leptin and Satiety00:07:30 - Leptin Resistance Explained00:08:02 - Normal Weight Obesity00:09:05 - Critique of BMI00:10:12 - Leptin Resistance and Metabolic Rate00:11:22 - Chronic Dieting and Leptin Resistance00:12:01 - Summary of Hormones and Stress00:13:43 - Genetic Component of Emotional Eating00:18:09 - Empathy and Emotional Eating00:21:09 - Identifying Patterns of Stress Eating00:24:08 - Recognizing Stress Levels00:25:01 - Stress Scale and Emotional Regulation00:27:07 - Chronic Stress and Hunger00:29:04 - Positive Stress and Dysregulation00:30:09 - Conclusion and Final ThoughtsFollow Dr. Ali Novitsky on Socials⁠⁠⁠⁠⁠TikTok⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Facebook⁠⁠⁠⁠⁠⁠Instagram⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠YouTube⁠⁠⁠⁠Work with Dr. Ali• Beginner Strength Training Program – 12 months for only $199! ⁠⁠⁠⁠⁠Enroll TODAY⁠⁠⁠⁠⁠• Total Fitness Program – A 12-month mind-body experience. ⁠⁠⁠⁠⁠Enroll HERE⁠⁠⁠⁠⁠• The Fit Collective® x InBody USA/Canada – Get 15% off select models. ⁠⁠⁠⁠⁠Click HERE⁠

Imagine the shock and horror of having a child be diagnosed with Acute Myeloid Leukemia, going through treatment for that for 8 months,, relapsing 2 months later, and then being told that the first diagnosis was wrong, and that the child actually had  Ewings Sarcoma. That is what happened to then 2 1/2 year old Connor Mocey who is now 5 years old and doing as well as possible while dealing with this difficult Bone Cancer. 

In this episode of Sexy Marriage Radio, we explore the complexities of relationships, focusing on the concept of regressions and how they affect emotional functioning. We discuss the different types of regressions, the impact of stress, and the contagious nature of regression in relationships. Our conversation emphasizes the importance of self-awareness and understanding one's emotional state to improve relationship dynamics. Takeaways Understanding regressions can empower individuals in relationships. Acute regressions are short-lived but impactful. Steady state regressions can go unnoticed and affect daily functioning. Stressful life events can trigger regressions. Recognizing triggers is crucial for managing regressions. The emotional state of one partner can influence the other. Communication is key to navigating regressions in relationships. Self-awareness helps in identifying personal regressions. High meaning situations can exacerbate emotional challenges. Assuming one is regressed until proven otherwise can lead to better self-management. Enjoy the show! On the Xtended version … In the XTD, we described what regressions look like - now we cover what you can do about them. Join us to find our. Sponsors … Everylove Intimates: Add spice and connection to your marriage with a Date Box. Get 20% off with our code SMR at https://everyloveintimates.com/smr Academy: Join the Academy and go deep The post Understanding Our Functioning Is The Key To A Better Marriage #727 first appeared on Sexy Marriage Radio.

Review of acute renal imaging for radiology board review. Download the free study guide on this and other free educational episodes at theradiologyreview.com. Prepare to succeed!Mentioned in this episode:Board VitalsRadiology residents—get ready for the ABR CORE Exam with BoardVitals! Access over 1,300 high-yield questions, detailed explanations, and adaptive learning. Study anytime with the mobile app, customize by subject, and track progress. Plus, a 100% pass guarantee! Start your free trial at BoardVitals.com and use code RADREVIEW for 10% off Radiology question banks. Thieme Today's podcast is brought to you by Thieme Synaptiq Radiology Spaced-Repetition Flashcards. Study better with pre-made, physician-curated flashcard decks in an easy-to-use app. Designed by a resident, Radiology Spaced-Repetition Flashcards are made to boost learning and save time. Click the link below to learn more.Explore Synaptiq Radiology Flashcards

Severe trauma is the leading cause of death worldwide for adults younger than 50 years of age. Acute traumatic life support (ATLS) guidelines endorse early and aggressive usage of supplemental oxygen in patients with severe trauma, at least until abnormalities of airway or breathing can be safely ruled out. However, unclear target concentration, duration or saturation goals often leads to hyperoxemia. Emerging studies in the intensive care unit (ICU) setting suggest that liberal supplemental oxygen therapy and hyperoxemia is associated with increased mortality. Limited evidence in the trauma population suggests similar outcomes.

In this episode of Welcome to Cloudlandia, we start with Dan's recent experience with stem cell injections, a journey filled with both challenges and relief. This discussion transitions into the inspiring story of a Vietnamese massage therapist who built her career in Canada, highlighting the diverse paths in the healing professions. Our conversation then shifts to the political landscape of Canada. We analyze the unique dynamics of minority governments and consider the influence of international figures like Trump on Canadian politics. We also discuss the role of central banking figures in political negotiations and reflect on the contrasts between Canadian and American electoral perspectives. Next, we explore the parallels between political and economic systems, examining the shift from traditional hierarchies to modern digital frameworks. The conversation covers the challenges faced by third-party candidates in the U.S., with a focus on Robert F. Kennedy's independent run, and delves into the economic tensions between China and the U.S., considering their impact on global trade relations. Finally, we reflect on the importance of creative consistency and the power of legacy. Whether it's maintaining a long-term streak of publishing or creating innovative tools, we emphasize the value of continuously producing impactful content. SHOW HIGHLIGHTS We explore the intricacies of stem cell treatments and discuss my personal experience with multiple injections, sharing insights on the healing journey alongside Mr. Jackson. The conversation transitions to Canadian politics, where we delve into the complexities of a minority government and the influence of international figures like Trump on Canadian political dynamics. We examine the parallels between political and economic systems, focusing on the evolution from hierarchical structures to digital frameworks, and discuss the challenges faced by third-party candidates in the U.S. electoral system. The geopolitical dynamics between China and the United States are analyzed, highlighting the differing geographical and demographic challenges and the economic tensions resulting from tariffs and trade negotiations. We reflect on the value of maintaining a long-term creative streak, discussing the importance of consistent output and deadlines in driving productivity and ensuring a legacy of impactful content. The discussion touches on the strategic importance of filling the future with new and exciting projects to ensure personal growth and innovation, contrasting past achievements with future aspirations. We explore the significance of creativity in producing meaningful content across various platforms, from books and workshops to podcasts, emphasizing the role of personal reputation and motivation in maintaining a steady output. Links: WelcomeToCloudlandia.com StrategicCoach.com DeanJackson.com ListingAgentLifestyle.com TRANSCRIPT (AI transcript provided as supporting material and may contain errors) Dean: Mr Sullivan, Dan:Mr Jackson, Dean: there he is. How are things in your outpost of the? Dan: mainland. Well good, I had a convalescence week. They really packed me full of new stem cells. And the procedure is things aren't good if I'm not feeling bad. Dean: That's what I'm saying. It's along the lines of we're not happy until you're not happy. Dan: How's that for a closing argument? Dean: That's good, that's good. Dan: Yeah. Dean: Things aren't good if you're not feeling bad. Dan: I got the procedure on the Thursday of last week, not the week we're just finishing, but the week. So Thursday, friday, saturday and it was almost one week later, exactly on Thursday, almost the same time of day, and all of a sudden the pain went away. Dean: Okay, how long was it Acute onset? Did you have to travel in pain? Dan: Yeah, well, I did, but they drugged me out. Yeah, they had sedatives Right when they were doing the procedure and then you had takeaways. Dean: Yeah, A goody bag. Dan: Nothing like a good drug. Yeah, exactly, especially a pa pain killing drug and and they're real big on this but went full force this time I had eight different injections, both ankles, both knees, even the knee. That's good they do it to reinforce what's already there. Reinforce what's already there. And then tendons the tendons in the calf, tendons in the hamstring, tendons in the quadriceps and then on both hips, both hips, so the left leg is the. You know in the spotlight here and when you're it's like you're experiencing inflammation in the ankle, in the calf, in the knee, in the upper leg and then the hip at the same time the leg doesn't want to, the leg doesn't want to work, right exactly yeah yeah, so that's the big problem, but actually I'm feeling pretty chipper today that's great, so that. Dean: So it took a week to get that. Is that usual or was this an unusual? Because I don't think I've ever heard you mention the pain. Dan: Usually it was a couple of days, but they got me while they had me. Dean: Well, that's good, and today you feel noticeably better. Dan: Now, yeah, I was noticing that we have a long-term massage therapist who comes to our house. Dean: Oh, my goodness. Dan: She's been coming for 33 years. Vietnamese Wow A boat person, actually, someone who escaped on a boat when she was a teenager, actually someone who escaped on boat when she was a teenager. And you know, really, she grew up, her grandmother was. They didn't have things like registered massage therapists, everybody just did massage, you know grandmothers especially, and so she learned from her grandmother. You know, even before she was 10 years old and so she's you, she's 60 now, 60 now. So she's been at this for about 50 years and she's availed herself of almost every kind of therapy training that there is. I mean, it was she was working till she was 45, from teenagers to 45 you know, paid for it before she ever got registered, she ever got. oh, oh my goodness, yeah, and I asked her about that. And the licensing is only really needed if the patient is claiming insurance money yeah. So they won't give me a patient any? Well, I never asked for it, I mean. I find I'm trying to get through my entire lifetime by having as little direct contact with government as possible. Dean: That's the best. I love that. Yes, that's great. Dan: I know they exist and as far as garbage being picked up, streets being repaired, police stopping crime. I have no complaints about paying for that, but I know I have to have some involvement but I don't try to expand it. Dean: That's so funny. What's the tone in Canada? Now here we are, you know, a week after the big debacle. Dan: Well, I don't know the debacle. They basically first of all didn't really decide anything because they had a minority government before for Americans. Americans only have winners and losers, but in Canada you can have someone who's half and half. Dean: They're half winners and half loser. Dan: Yeah, they're like. You know. It's that less than half the country voted for the winner. That's right. But the winner got more votes than the second place because there's more than one party. You know, americans don't believe in anything. That's not a winner or a loss. You know. That's one thing. I've learned since I've been in Canada. Americans, there's only two possibilities You're a winner or you're a loser. There's no halfway. There's no participation prize for showing up and being engaged, I think, the prime minister. He's an economist and we have a thing that it would be like the head of the Federal Reserve. In the United States you have a central bank which is called the Federal Reserve, and in Canada it's called the Bank of Canada, and then in the UK they have the Bank of England, and this man was both governor of the Bank of Canada and the governor of the Bank of England. He's a lifetime bureaucrat. He's never been anything except a bureaucrat and his first job is to negotiate with Trump. Right exactly, and nothing in his background has prepared him for this experience. Dean: Yeah, that's so. It is true, isn't it? I mean the whole, I think it feels like from this view. Dan: They kicked a can both the US and Canada. Dean: And the you know. The very interesting thing is that this vote definitely feels like a not Trump type of sentiment. You know more than it did yes. Dan: There's no question in my I mean there's no question in anyone's mind that Trump was the issue. Dean: Yeah, yeah, Pierre Polyev's probably going. I was so close. If that election had happened any time between November and January, it would have been a whole different story, you know. Dan: Yeah, yeah, yeah, that was. I think. Yeah, I don't know. Yeah, I think it was that the you know. Yeah, yeah, yeah, that was. I think. Yeah, I don't know. Yeah, I think it was that the you know Trump actually putting his gaze on Canada, really, didn't happen until after, you know, after he was inaugurated after he became president, I think you're totally correct. It was from November 5th to January 20th, yeah that would have been Kaliev's window. Yeah, but yeah well, you know there's a little history to this. A lot of people don't know it, but Canada was a major country you know in world affairs pretty well for most of the 20th century, pretty well for most of the 20th century, and part of the reason is that they were the big backup to the British Empire, like in the First World War and the Second World War. The major supplier of manpower and armaments and everything else came from Canada that backed up the British. I mean, the British were really in the eye of the storm for both of the wars, but their number one ally right from the start of the two wars was Canada. Canada was the big player. As a matter of fact, in 1945, the end of the Second World War, Canada had the third largest navy in the world and they had the fourth largest air force in the world. Think of little canada little canada yeah, and they played a huge part in the cold war. You know the rcmp, the, you know the mounties most people think of them as people in red coats riding on horses, but actually they were the. They were actually the dual they were were the combination of the CIA and the FBI. They were all packed in one. And they were a major player, because the United States, canada, was the country that was in between the United States and the Soviet Union. So I'm going to sneeze. Oh, there I go, yeah, that's completed, anyway, anyway, and their intelligence services were first class and everything. And then when the cold war suddenly ended in 1991, the end of 1991, all of a sudden their importance in the world just disappeared. So we've been and they've had to fake it yeah, it's interesting. I mean canada, I guess, and that's basically that and the you know you had some good prime minister you had. You know the liberal crechin wasn't too bad because he was a long time tough guy in the liberal party and harper I thought was, and my experience of being in Canada, which is 54 years, I think, Harper was. Dean: Well, he's always widely regarded as that right. Dan: He's by far the best prime minister and he wasn't confused about what Canada should be for, what it should support and everything like that. And then you came. You know, obviously they got the next character from central casting. You know, they just said send us, send us and he's by hands down. I mean, if you really talk to the liberals quietly and in private, they said you know, he's kind of a disaster, he's been a disaster for 10 years and you know. I mean they just don't have much gas in the gas tank anymore at that party and there's a general pushback against left-wing parties going on in the world right now. You can see it in Britain. They had the elections for local councils. You know local councils, which is it's an odd, you know it's an odd sort of election, but they have it sort of like midterm elections in the United. Dean: States, you know and Nigel Farage. Dan: Who's the you? Know, he was the Brexit, he was the brains behind Brexit. I mean, very clearly, if that had been the general election, he'd be the prime minister right now and he wants to just detach Great Britain completely from Europe and have the attachment with the United States, and I think that's going to happen. What's disappearing is this sort of wishy-washy, left-wing mushy-ness in the world right now. The world's going very binary in my sense. That and a $9 latte you got yourself a deal. Dean: Oh, my goodness. Dan: Is that what it's come to? Dean: Is that what it's come to? Is that what it's come to? The $9 latte? You know, it's so funny. I'm going to be back up in June, of course, and I'll be setting up residency in Yorkville there for several weeks, and last time I was there I was surprised by the. You know I usually get Americanos which are now have been replaced by Canadianos, but it's a whole new whole new, whole new logo. Dan: Yeah, I mean, how can I be against patriotism? Dean: I think so, and it's so amazing, though, to see like just the lengths that they're going. You know, I mean pulling all the. That was the big news when I was there. Dan: And I'm wondering if it's. What I noticed is that Canadians are demonstrating every aspect of courageousness that doesn't cost you anything. Dean: Well, I think that it's going to cost. I mean, you know, there I saw, is it Doug Ford or Mark Ford? Doug Ford was up, you know, in the liquor store in the LCBOs saying how they've pulled all American brands out of the LCBO and that you know they're like taking a stand about. But that total buy of the LCBO is $3.2 billion is what they're saying. The liquor market is $340 billion. So less than 1% of the whole. It's not even too little to measure, even you know. Yeah. Dan: Well, they can do it because the LCBO is Liquor Control Board of Ontario. Dean: The largest. Dan: The largest on the planet, Not just the largest in North America. Dean: the largest on the planet. Dan: There's one bureaucratic office that you know that's, that's a lot of liquor. Yeah well, you know it's, it's a bit. You know you're dealing in symbols here, it's sort of symbol. I mean, it's not yeah, it's not actually. It's not actually real courage. You know it's not real courage. It's symbolic courage you know, it's a symbolic. Symbolic, and you know, but that's part of life too, you know. And you know, I'm really noticing. Do you ever, in any of your video viewing, do you ever watch the Bill Maher show? Yes, I do, yeah, and I watched him in the old days and I watch him. You know, I don't actually watch television, but I get YouTubes. I get YouTubes of it, you know. And Trump invited him to come to the White House or the White House or Mar-a-Lago. I don't know if there is Mar-a-Lago, and you know Barr, who has been. I think actually. Dean: Focally anti-Trump yeah, yeah. Dan: well, trump had printed up a document which said 60 insults that Bill Maher had insulted Trump or Bill Maher had done it. And he wanted to give it as a present to the president and he said you know, these are my 60 insults of you. And Trump said oh, can I sign that Trump autograph? That's the best, and Maher came away and he says you know, can I sign that? And Trump autographed it. That's the best, I autographed it. And Maher came away and he says you know, I want to tell you it's not a crazy man in the White House. He said I was treated, you know, it surprised me how gracious he was and you know how just open to having a chat and everything like that. Well, he's just been slammed by the left wing that he would even show up and that's all this fake symbolism, you know, but attack the only guy on the Democratic side in the United States who is actually positioning himself differently is this guy Fetterman from Pennsylvania. He's the senator and he's someone who really hasn't done anything in his life, but through just the way politics were working, I think he had a state job and then he ran and he's got mental issues. I mean, he's had mental issues, but he's been a voice, a lone voice. You know a singular lone voice of somebody. He said you know politics, you try to find common ground and wherever you can find common ground with the opposition, you sit down with him, you talk about it and the public benefits if you can get an agreement there. Well, he's just been. He's just been cast out, but he doesn't really care. He doesn't really care, so you know yeah anyway, but it's an interesting time and you know what? I've got a thesis that politics takes on gradually. It takes on the form of economics. Okay, so that, however, the economics of society, the structure, you know, how do things get created, produced and where's profit being made Ultimately politics takes on the same kind of structure. So if you think of the industrial revolution, when everything was defined by big pyramids organizations, you know you had people at the top and then you had either big factories or you had big administrative companies that did the work out in the world. For the factories, you know the research, the marketing and distribution out into the world of manufactured products. After a while, government took on the same form, the big pyramids. Government always is the last institution to figure out what's going on. Dean: That's interesting, it's true, right, because everything has to trickle up. Dan: Yeah. So starting in the 70s, you started to get a change in the structure and you went from the big pyramidal structures to basically the microchip networks. Everything started more and more to be on the framework of computers, individual computers communicating with other individual computers, you know communicating with other individual computers, first hundreds and thousands and then millions, you know, and gradually. But the central principle of the microchip is binary, that in the digital code things are either a one or they're a zero. Okay, and so what I noticed over the last, probably starting in the early nineties, you start getting you're either on one side or the other side. But my sense is that politics is just imitating how the economic system it's a digital economic system. That's what we're talking about on. Welcome to Cloudlandia. What allows this amazing communication that we can make digitally depends on ones and zeros. And what I noticed is that the entire political structure, you know all the players in the political structure. You're either on one side or you're on the other side. If you're in the middle, you don't count. Dean: Yeah, and that's you know. It's interesting. You were talking about the third party system. I think that the interesting thing is, the United States is really a three party system. There's three parties, but really, you know, in a two party system, I think that's really what it is, but there's a large majority of people who are more moderate. Right now, it's binary in terms of you're Democrat or Republican. That's really it, and there's never been, there's never been, you know, a real outsider opportunity. I mean, you look at, you know, ross Perot. Maybe he was the got the farthest. Well, they're a spoiler. They're a spoiler. Dan: They're not, they could never be the lead party. Dean: You know, they're just a spoiler party. Dan: Yeah, and the reason is because of the Electoral College. You know that. I remember being at Genius Network in the year before the election, so the election was last November, so it was the previous November and Robert Kennedy was running. Robert F Kennedy was running. And then the Democrats made it impossible for him to be a contender, a Democratic contender. So he went independent and I remember him. He came twice, he came twice to Genius Network. Dean: And. Dan: I remember the first time he came, everybody was excited. You know he's going to be the next president and I said, yeah, yeah, I said well, you know if you want to know how the game's played, you got to take the game box and flip it on the back and read the rules. And I could tell you he could take 30% of the total vote. You know that would be. You know that'd be something like 45, 50 million. Unheard of yeah 45, 50 million and he wouldn't get one electoral vote. Dean: Right. Dan: And I said, and they said well, that's just absurd, that's just absurd. And I said nope, that's how the rules, that's what the rules are. I said, learn what the rules are. And that's why I think it was so easy for them to jump. I mean, if he had run right through to the end of the election and you know, like he was showing up on election night, you know and he got 3% of the three. He could have gotten tens of millions of votes and gotten, maybe, but wouldn't have won a single electoral vote. Dean: Right. Dan: Yeah. Dean: Yeah yeah, I like your approach and mine just being in it but not of it. It's like I appreciate the things Well it's entertainment yeah, it's, you know. Dan: It's entertainment that costs you a lot more than cable, that's exactly right. Dean: And you know what the good news is, dan? There's no tariff. There's no tariffs on good ideas, no tariffs in Cloudlandia Tariff free. I think that's the big thing. Dan: If it doesn't weigh anything, there's no tariff. Dean: That's right. That's right. If it doesn't come in a box, there's no tariff. That's exactly right. That's right. If it doesn't, comeia is so. Fascinating to me is just seeing how unstable the mainland things are becoming. Dan: You start to see the Cloudlandia future. We're in a period where we're going to see the greatest amount of chaos and turmoil in the tangible I'll talk about the tangible economy, yeah, but I think it'll be about probably a decade and then things will be remarkably stable. Dean: How do you see this playing out? Because I've been curious about that too. You see this playing out like so, because I've been curious about that too like what is the end game of all of these? You know the I guess you kind of take this intersection of what you know, the populations and the, you know the movement to cloudlandia, and then these, the political to Cloudlandia, and then the geopolitical climate. You see all these things like what is the unintended? We wonder now I've heard different things about China, all these countries or whatever, that Trump is imposing the tariffs on, the reaction, the rebound reaction of that. Is that something that Peter Zion has talked about? Or is that what's your take? I know you've read a lot and observed a lot. Dan: It's very interesting. I think he's very conflicted. I think Peter Zion is very conflicted right now, and the reason is that he made predictions 10 years ago. I'd say it was 10 years ago, about how he saw the world changing. It produces all sorts of interesting insights. And the first one is that, basically, as a country, the future of your country past, present and future of your country is really determined basically your geography, where you are on the planet and what kind of geography you have, so your placement on the planet. I'll use an example of let's use China as one and use the United States as the other. The China is basically a land country rather than a maritime country. If you look at the map of China, where it shows the cities, most of the cities are inland in China. Even Beijing is not close to the ocean. You have two big ports. One of them is Shanghai, which is actually up the river, but it's got a very wide mouth to the river, and then Shanghai and the other one was Hong Kong, and so they're basically Hong Kong, hong Kong and so they're basically a land-based country, but they border on 13 other countries who have a passionate hatred for China. These are enemies, they're surrounded by enemies. There's nobody who likes them, and one major country that's offshore is Japan, and there's nothing but pure hatred between Japan, and everybody else has an adversarial attitude towards China. So that's China. Then you take the United States. The United States sits with 3,000 miles of water on its eastern shore, 5,000 miles of water on its western shore shore, 5,000 miles of water on its western shore, and then it's got just. The only connector is the Mexican, and it's 200 miles of desert and mountains. And then on the north you have 3,000 miles of pot-smoking Canadians. Dean: Terrorists hiding pot-smoking Canadians. Dan: Yeah, terrorists who had a plan for tomorrow but forgot what it was. So the US really doesn't have to. China has to totally defend itself. You know they have to spend an enormous amount of their budget defending their borders where the US really doesn't. I mean there's they talk about, you know, the Canadian-American border they talk about. You know that, you about that actually there's just nothing there. It's just fields and there's farms, farms certainly in the West, in Manitoba, saskatchewan and Alberta where. I'm sure the farms are partially in the United States, partially in. Dean: Canada, you could just walk right across. Dan: Yeah, oh, yeah, it's you know, and everything like that. So one thing is the US really doesn't have to. By the standards of the world, the US doesn't have to spend much money defending itself territorially. The other thing is demographics, and it's what your population looks like. Do you have mostly, is it mostly young people? Is it mostly middle-aged people? Is it mostly old people? And the US is China probably by 10 years from now will have more people over 60 than people under 20, which means that they become more and more of a top-heavy population. And these people are past working age, they're past investment age, but they're not past being in an expense age. So more and more, the cost of your society is older people, and you have fewer and fewer workers who are producing, fewer and fewer workers who are paying taxes, fewer and fewer workers who are, you know, who are investing, and you have older, older population. That's just consuming and it's just consuming. Yeah, so these are the two big things that you have to think about. It's China and the US and tariff. A tariff that the United States places on China is five times a heavier penalty than one that China places on the US. Dean: And the. Dan: US, like Trump, everybody else in the world. He put it 10 percent, 25 percent, some of 50 percent. On China, he put 145 percent and apparently there's riots going on in China right now because the factories are closing down really fast. You'll see within the next three months, you'll see next month. So it'll be formal new negotiations between the United. States and China. Now that's the central issue as we go forward what's the relationship between these two countries? It's like after the Second World War? What's the relationship between the United States and the Soviet? Union the basic attitude is that we'll just keep applying more and more pressure and wait them out and they'll collapse. So that's what I see the big game for the China. Dean: And do you think that the net of this is that will bring back? Like what is everything? Is that setting up you know what kind of the playbook that Peter Zayn was talking about, the absent superpower of the US, sort of moving away from dependence or interaction with outside? Dan: No, no, I just think it's a one-on-one that the United States is going to have with every other country in the world. So there's 200 countries according to the United Nations. There's 200 countries and every one of them is under some sort of broad trading agreement with the United States. And the US did that basically for security reasons, because they said we'll make it easy for you to trade, but your military strategies and your security strategies have to have to be in alignment with us. And when the Soviet Union collapsed there was no need for that, but it just went on by inertia. Basically, it was just something that carried on. It was a good deal for everybody else, but not such a great deal for the US. And Trump comes in, you know, and Trump is nothing if not a dealmaker, you know. So what he says is every country now you make sure you send somebody to Washington because we're going to do a dealmaker. So what he says is every country, now you make sure you send somebody to Washington because we're going to do a different deal. So I think probably within a year you'll have probably the US will have deals with, if not China, they'll have deals they already do with China, south Korea, india, vietnam in that part of the world, the Philippines, australia, and so everybody will be in the new American deal except China. And probably within a year you'll have more than 100, maybe 130 countries who now have new deals, including Canada. We'll see what Canada does, because Maybe a year from now we'll be back to drinking Americanos at Starbucks. Dean: I wonder. That's what I wonder. Dan: It's just amazing to me, why stop with Canadiennes? Why don't we go to Ontariannes? Uh-huh, exactly, toronto. I mean, if you're going that route, why not go all the way? Dean: Toronto, yeah, York. Dan: Villano. Dean: Uh-huh right, that's the thing I stay on the island there. That's right. That's so funny, yeah, so that's I mean, you know? Dan: I mean I'm just an amateur observer here and I'm just picking up what I see happening. But the big thing is to have every deal that the United States has as separate with each individual country, no broad multilateral agreements. And so the big thing is that the word tariff is a bit of a distractor. It's not actually a tariff. That's the penalty if you don't do the new deal. So that's how they do it. He says let's do a deal because right now you guys can sell stuff into the United States with hardly any expense, hardly any. But you make it very difficult for us to sell our stuff into your country. And so let's do a new deal. Let's do a new deal and so let's do a new deal. Dean: Let's do a new deal. How's this affecting the dollar, by the way? Dan: It's down. As far as I can tell, it's down about five cents. It's from 144 to 139. I think it's 138. I think it's 138.5, something like that, but a year ago it was at 132 or 133. So it's still five, six cents above, yeah, yeah. It's a good deal. Dean: Yeah, Still a good deal. Still a good deal. Yeah, it's so funny. Well, Dan, I've been looking. I've been continuing on the dip into history, continuing on the dip into history phase, looking. It's been a fun thing. Every week I've just kind of been randomly selecting a core sample of my journals from the last 30 years now and it's very interesting to look through and see those things. I've been thinking about streaks too. Like you know, this last your 70s of 40 books in 10 years is a pretty good streak. I was thinking back that Dan Kenney has been publishing his newsletter monthly since 1992. And I think about that. You know 33, 34 years, this year of a you know, around 400 newsletters 16 page, just single space, nothing, no special, no design, nothing like that around it, but just that. You know, essentially just along the lines of what your global thinker. Global thinker was just like a series of essays kind of thing. I guess is what you would call it right, but that's kind of what Dan's done for 34 years. Yeah, pretty amazing. And I was thinking, you know I've done, I've had 30 years now of very consistent output to an audience of one, and I sure realize what a you know what an amazing body of work this is. Dan: I hope that audience of one is appreciative. Dean: Yes, exactly, very appreciative, you know, and it's so funny, right? Dan: You're playing a high stakes game here. Yes, exactly. Dean: I've had one satisfied subscriber for 30 years, you could lose your target market in a bad week, you know. Uh-huh. Dan: Exactly. Dean: Yeah, I mean, it's kind of funny, right, but I could see, you know, all these things they start. This is where they start and they in Manly specifically, and I was talking, this was the very beginnings of the who, not how. So this was August of 2015. And I think it was November of 2015 at the annual event that I sort of talked about that idea of the thing. But it's funny, this was scientific profit making came out of this, that journal, so that looked at the breakthrough DNA process as so very yeah, it's just the, you know, I think, the decision that you've, you know that consistent output gallery, I guess we'll call it or distribution model. It's a very it's really. Do you still journal internally? Or how do you what gathers, the notes and the thoughts that make the quarterly? Dan: books. Well, I have the. You know I have that series, the one new book every quarter. I have the new tools. Dean: Now my goal. Dan: I'm not up to speed yet on the complete capability of doing it yet. But, my goal is to create one new thinking tool every week okay, yes and and that I don't have, you know, a public need for that in other words that the tools are for new workshops. It's to keep the system supplied. You know, and I have. You know, I and I have free zone workshops every quarter, just three of them, but I have four Zoom two-hour workshops every month. So if you line them up and then I have podcast series I have podcast series. So there's really hundreds of activities that are in the schedule really on January 1st, you know on January 1st, you'd look out and say by December 31st how many scheduled public if you call them public impact activities do I have? Dean: You know it'd be over 200,? Dan: certainly yeah. You know one thing or another, and they all require the creation of something new. You know right you know, and one of the things that I've. You're on a really interesting subject here, because each of these has public impact, you know a book does. There are people who read the book, there's workshops, people who attend the workshops, people who listen to the podcast. And then the new tools themselves, which have the necessary. They're necessary to keep the program new. You know the workshops, and I have teams that take what I'm doing and they apply it to the workshops that I don't coach. We have the other coaches. And then the other thing is that, you know, within the last two or three years we realized that the tools can be patents, and so we're up to 61. Now we have 61. And so these are all one thing that they really keep me busy. Okay, and I'm very deadline responsive. I really like deadlines. I really like it, you know, because I mean, for you and me, we've got one problem what's important enough in our life that we would actually focus and concentrate on it, that we would actually focus and concentrate on it. And I find deadlines where other people, my reputation as at stake, really is very important for me because I get real serious. You know, I'm pretty lenient with me failing myself. I'm not lenient with failing other people. Dean: Right, yeah, me too, that's right. Dan: Yeah, my reputation is very important to me, so you know I don't want the word going around. Dean: Dan's starting to lose it you know no way, yeah, no way. Dan: Yeah, he's fading, he's fading, you know, and anyway. So that's really it. But I came up with a concept, just to put a name on something, that what makes people older not physically but physically, ultimately, but what makes you older intellectually, emotionally, psychologically is that your past has more living another day, that your past is going to fill up with stuff. So you have to work at filling your future up so that the stuff in your future is much, it's much more valuable than what you had in your past. So what I try to do is always favor the future in terms of stuff. I'm going to create stuff. I'm going to do that. It keeps getting to be a bigger game in the future than I ever played in the past. So that's sort of the you know that's. You know the essence of the game that I'm playing with my own life, with my own life, right. Dean: Yeah, this is really, I mean, and that's kind of, do you ever see? I mean, there's no real. Dan: I imagine you'll keep this cadence up continuously that there's still to do the to do 40 more 40 more quarterly books in your 80s 57, I'm on 43, I'm on 43 right now, so it's 57. Dean: 57 more. Dan: Yeah, which is oh, no, no no, is that no? Dean: how many are you For the 10 years? Dan: you're still going to go quarterly? Yeah well, I'm on quarter 43 right now so I see, right, right, right, yeah so. And the quarter. Actually, we're starting it this week. We just put one to bed and the next one starts this week. So that's 57 more and that takes me till about 95. I'm about 95 years old. 57 divided by 4 is 16 and a quarter 16 years and one quarter. And then I have my podcast and the workshops and everything else? Dean: yeah, how many of your podcasts are weekly podcasts like this? Dan: no, I don't have any weeklies we have. We have a certain number for each of them and sometimes, you know, I don't think there's any podcast exception. You and jeff would be the most podcast, jeff madoff, that I yeah, and that wouldn't be 52 weeks. That would be, you know, maybe 30, 35, because we have times when we're not able to do it right, exactly off weeks, not many, but we do yeah. Dean: Yeah's very so that's, you know, looking forward. For me, that's kind of a good thing here. You know this. I'm going to join you in this quarterly cadence here, you know, as I look forward for the next 30, the next 30 years, I mean I already write enough volume to do it. It's just a matter of having the stuff in place. If only I owned a company that makes books. You know they don't have to. Dan: They could be you know, books you can write in an hour, 90 minutes say. Well, the big thing with Dan Kennedy, I mean, if you look at his monthly newsletter if he would take three of them and put them into a different format. He could have oh, yeah, oh for sure, Absolutely. Dean: That's my thought, right. My outlet is really these emails that I write. I think they're really episodic thought kind of thing. I think they're really episodic thought kind of thing. So I'm just really going to get into that cadence of having that output. I think that's going to be a nice valuable thing, Because I look back over the, I look at this 30-year inflection point here, you know, and look at what's changed and what's not going to change you know, and it's very interesting when I start getting to the bedrock things, like if I look at lifestyle design, you know, purpose, freedom of purpose, freedom of relationship, freedom of money, all of those things that I'm very like, consistent in my desires and I think everybody is like, for me it's really, I look at it, that you know what's not gonna change in 30 years. I'm, I want to get eight hours of great sleep, everything. I want to wake up, I want to eat great food, I want to have, you know, two or three hours a day of creative work and have fun. And that's really the, that's really the big game, you know, row your boat gently down the stream, that's the, that's the plan, you know. But I think that having these, I think having these outlets, you know, I think that's really been the great thing. When you have all these workshops and the tools, you've got a gallery for everything. Dan: Yeah, Well, and you know, I mean they get better. I mean, I mean the teams that are involved in this. I mean, there, there isn't anything that I do that doesn't involve a team. You know the workshop team, the book team, the podcast team, you know the my artists, my writers, you know? The sound engineers and everything like that. And and it gives structure to their lives too. You know like they basically and they get better things I notice every quarter things happen faster, easier there's. You know we're getting them done. The overall quality keeps improving from quarter to quarter. I can take a book. You know, like if I took book 30 and compare it to book 42, which we just finished on Friday. I mean the quality of it is just much, much higher than it was. Dean: And. Dan: I don't really angst about this you know, I just know when people. They're really good at what they do and the teamwork keeps improving and they keep getting better quarter by quarter. It's going to improve the product and I'm a great belief that quality is a combination of successful consistency and duration times. Duration that you have a consistency where you can get better at something. You do it once. Second time you do it better. Tenth time you're ten times better at it. Compound interest yeah, that's really Like compound interest, yeah. Dean: Yeah, and that consistency over that time, that trajectory is only going up and better. Dan: Yeah and then it pays for it. You know it pays for itself. You can't be in a net deficit money-wise with these things. They have to pay for themselves. Like right now. I would say that the quarterly books in the podcast the podcasts are, you know one person's, you know one or two people, right, exactly the tools totally pay for themselves because that's the basis for getting paid for the workshops. Dean: Right. Dan: And of course they have IP value now. Dean: Do you have your? Are the books available on Amazon? Yeah, quarterly Amazon, yeah, quarterly books yeah, yeah, yeah. And do they sell organically? Do you sell those? 0:48:43 - Dan: Oh, yeah, oh yeah, yeah, I mean, yeah, I mean it's not a big, you know, it's not a big budget item, you know and everything like that my whole thing is just that the entire production costs get paid for in a year yeah, I get it yeah, yeah that's awesome, yeah yeah, and, and you know, and you know it's part of our marketing, you know it's part of our market but they yeah, and every once in a while one of the little books becomes a big book, and then they write for them. Dean: So then, they really pay for themselves. Yeah, yeah, yeah, yeah, I love it. Well, it's exciting, it's got a whole lot. It's like a farm. Dan: I have sort of an agricultural approach. These are different crops that I have. You keep the soil healthy and pray for good weather. Dean: Yeah Well, it's quite an impressive like. When I look at my Dan Sullivan bookshelf, you know it's like quite a collection of them and consistently I mean the same look and feel of every book Every quarter. Yeah, amazing. Dan: Thank you. Thank you Appreciate it. Dean: Yeah. Dan: You're being impressed with. This was my intention that's exciting. Dean: Right from book number one, propose a contest. Dan: Let's do it. Dean: I think I could do that too. I'll race you back. We went from roaming the streets of Soho in London to being in Strategic Coach in Toronto with a book in hand. Dan: Speaking of which, I'll have Becca get in touch, but our next call will be in London, so we're in London, we leave next Sunday We'll be in London. So it won't be on the Sunday, though, because I'll be jet lagged and Becca will arrange in London. So it won't be on the Sunday, though, because I'll be jet lagged and Bab Becca will arrange for you With Lillian. Dean: Yeah, that's fine, yeah, so that's awesome. Dan: And then I'll be up. We'll be seeing you in June. We'll be seeing you. Dean: That's exactly right. Dan: Yeah. Dean:* Yeah, awesome. Okay, have a great day. Take care. Thanks, dan, bye.

To TIPS or not to TIPS? More than ever, younger patients are presenting with acute portal vein thrombosis (PVT) that requires intervention beyond anticoagulation alone. These patients need safe, effective options that offer long-term resolution and a good quality of life after treatment. In this episode of the BackTable Podcast, Dr. Benjamin May, Interventional Radiologist at Weill Cornell Medicine, discusses the evolving treatment landscape for acute PVT.---SYNPOSISDr. May shares insights into the changing interventional approaches, highlights the utility of tools such as suction thrombectomy devices, and explains how his best practices have developed over time. He emphasizes the continued importance of anticoagulation therapy, explores the potential complications and outcomes of various interventions, and discusses how thrombus location and characteristics influence his clinical decisions. With real-world scenarios and a step-by-step walkthrough of his decision-making process, Dr. May offers a comprehensive look at modern strategies for managing acute portal vein thrombosis.---TIMESTAMPS00:00 - Introduction 05:46 - Diagnosing Portal Vein Thrombosis10:52 - Management Options for Acute PVT and What is Safest?21:09 - Choosing an Intervention Approach26:19 - Tackling Large Bore Thrombectomy32:37 - Learnings and Tips for Successful Thrombectomy39:50 - Impact of Thrombus Location on Intervention Approach 45:01 - Post-Care and Follow-Up49:46 - Final Thoughts and Encouragement---RESOURCES“Transjugular Intrahepatic Portosystemic Shunt and Thrombectomy (TIPS-Thrombectomy) for Symptomatic Acute Noncirrhotic Portal Vein Thrombosis” (Shalvoy, 2023)https://www.jvir.org/article/S1051-0443(23)00341-X/abstract

Today, I am thrilled to connect with my dear friend and colleague, Dr. Stephanie Estima. Dr. Estima and I have similar audiences with many of the same concerns, so we decided to join up for a special episode where we can provide accurate answers to questions from the women in both our communities.  In our discussion, we dive into several topics we often get asked about on social media, including weight gain, insulin sensitivity, and how to identify where we are in terms of peak fertility years, perimenopause, or menopause. We discuss the significance of protein, looking at ways to increase our protein intake, the benefits of intermittent fasting, and when to consider doing that. We also explore how stress and hormones affect us in middle age, and we unpack some relevant research on fat loss and ways to fuel ourselves for exercise.  You have much to learn from today's insightful and empowering conversation with Dr. Stephanie Estima! IN THIS EPISODE YOU WILL LEARN: How the fear-driven content in wellness circles can cause anxiety instead of providing solutions Why previously effective diets may need to change during menopause Vilifying carbs and negative consequences if a keto diet or fasting is maintained long term How menopause impacts the gut microbiome Perimenopause and menopause are just natural stages of life and not indicators of decline. Strength training and why it's never too late to start Benefits of eating protein first in meals  Practical advice for managing health challenges during menopause Acute stress vs. chronic stress Will fasting intermittently before exercising burn more fat than fasting afterward? The importance of adopting a balanced approach to exercise and nutrition Connect with Cynthia Thurlow   Follow on Twitter Instagram LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Connect with Dr. Stephanie Estima On Instagram  On her weekly podcast, Better! With Dr. Stephanie

In this episode, I dive deep into the transformative world of regenerative medicine with Dr. Ed Park—a leader who has spent nearly two decades pushing the boundaries of aging and healing. Curious about exosomes and how these tiny biological messengers are redefining our ability to recover from injury, illness, and even chronic conditions? You'll love this conversation.   What we discuss: Why exosomes? Origins, discovery, and benefits of stem cells ... 00:03:00 How exosomes communicate and trigger healing ... 00:06:00 Exosomes for neurological repair and brain injuries ... 00:10:00 Exosome delivery: IV, targeting, and blood-brain barrier ... 00:12:00 Exosomes in musculoskeletal injuries and healing rates ... 00:18:00 Patient selection, expectations, and placebo effects ... 00:23:00 Exosomes for immune system support and aging ... 00:30:00 Lifestyle pillars alongside regenerative medicine ... 00:32:00 Exosomes in cardiac and nerve repair ... 00:34:00 Provider training, resources, and Dr. Park's practice ... 00:43:00 Closing remarks and medical disclaimer ... 00:45:00   Our Amazing Sponsors: Timeline: Mitopure: is a breakthrough supplement that promotes cellular renewal. It contains Urolithin A, which helps your body clear out damaged mitochondria and create new, efficient ones—giving you more sustainable energy. Timeline is offering 10% off your order of Mitopure now. Go to timeline.com/NAT10.   Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

Show notes at pharmacyjoe.com/episode1022. In this episode, I'll discuss animal data on the rate of correction for acute hypernatremia. The post 1022: Can Animal Data Inform the Ideal Rate of Correction for Acute Hypernatremia? appeared first on Pharmacy Joe.

Join us for part 2 of our informative discussion with Dr. David Vitale, a pediatric pancreatologist at Cincinnati Children's Hospital. In this episode, we dive deep into acute recurrent and chronic pancreatitis, distinguishing the two, and exploring the causes, genetic predispositions, and available treatments. Whether you're a budding pancreatologist or a PCP, this episode offers valuable insights into managing and treating this challenging condition.