Podcasts about periprosthetic joint infection

Dr. David Huang is Senior VP and Chief Medical Officer at Peptilogics and working to change the approach for treating and reducing reinfection rates of periprosthetic joint infection, PJI. Their lead highly charged peptide PLG0206 has been shown to be broad spectrum and active against multi-drug resistant bacteria, common causes of PJI. Peptilogics' AI/ML platform is accelerating peptide discovery to reach better clinical candidates in therapeutic areas such as rare diseases, immuno-oncology, and immunology. David explains, "Peptilogics' approach to changing the treatment paradigm for treating PJI is by treating PJI directly at the site of infection. Instead of administering an antibiotic systemically or by mouth, as mentioned earlier, Peptilogics has an engineered cationic peptide and an irrigation solution that can be administered directly to the site of infection in the wound cavity of the knee, for example. The knee does not have a great blood supply. Therefore, antibiotics given intravenously or by mouth have a difficult time getting to the site of infection in the knee." "Peptilogics' lead peptide called PLG0206 is an engineered cationic antibacterial peptide, which has orphan drug QIDP, which stands for qualified infectious disease product, and fast track designation from the FDA. And the way that PLG works is by its novel mechanism of action. It selectively binds to and disrupts the integrity of the bacterial membrane by altering the physical characteristics of the membrane, leading to a rapid loss of the bacterial cell membrane potential that results in cell death." @Peptilogics #Peptilogics #PJI #PeriprostheticJointInfection #Peptides Peptilogics.com Download the transcript here

Dr. David Huang is Senior VP and Chief Medical Officer at Peptilogics and working to change the approach for treating and reducing reinfection rates of periprosthetic joint infection, PJI. Their lead highly charged peptide PLG0206 has been shown to be broad spectrum and active against multi-drug resistant bacteria, common causes of PJI. Peptilogics' AI/ML platform is accelerating peptide discovery to reach better clinical candidates in therapeutic areas such as rare diseases, immuno-oncology, and immunology. David explains, "Peptilogics' approach to changing the treatment paradigm for treating PJI is by treating PJI directly at the site of infection. Instead of administering an antibiotic systemically or by mouth, as mentioned earlier, Peptilogics has an engineered cationic peptide and an irrigation solution that can be administered directly to the site of infection in the wound cavity of the knee, for example. The knee does not have a great blood supply. Therefore, antibiotics given intravenously or by mouth have a difficult time getting to the site of infection in the knee." "Peptilogics' lead peptide called PLG0206 is an engineered cationic antibacterial peptide, which has orphan drug QIDP, which stands for qualified infectious disease product, and fast track designation from the FDA. And the way that PLG works is by its novel mechanism of action. It selectively binds to and disrupts the integrity of the bacterial membrane by altering the physical characteristics of the membrane, leading to a rapid loss of the bacterial cell membrane potential that results in cell death." @Peptilogics #Peptilogics #PJI #PeriprostheticJointInfection #Peptides Peptilogics.com Listen to the podcast here

Dr. Laura Certain (@laura_certain) and Dr. Nico Cortes-Penfield (@Cortes_Penfield) join Dr. Julie Ann Justo (@julie_justo) to discuss all things related to prosthetic joint infections. Tune in to learn about what comprises a bacterial biofilm, how it develops, and ways to combat it using the latest evidence-based antibiotic regimens. We also take a look at what's on the horizon for the field of orthopedic infectious diseases. Learn more about the Society of Infectious Diseases Pharmacists: https://sidp.org/About Twitter: @SIDPharm (https://twitter.com/SIDPharm) Instagram: @SIDPharm (https://www.instagram.com/sidpharm/) Facebook: https://www.facebook.com/sidprx LinkedIn: https://www.linkedin.com/company/sidp/ References: Cortés-Penfield NW, Kulkarni PA. The History of Antibiotic Treatment of Osteomyelitis. Open Forum Infect Dis. 2019 Apr 8;6(5):ofz181. doi: 10.1093/ofid/ofz181. PMID: 31123692. Bernard L, et al. Antibiotic Therapy for 6 or 12 Weeks for Prosthetic Joint Infection. N Engl J Med. 2021 May 27;384(21):1991-2001. doi: 10.1056/NEJMoa2020198. PMID: 34042388. (DATIPO trial) Gallagher C, et al. Impact of Implementing an IV to PO Antibiotic Treatment Protocol for Orthopedic Infections ion Prescribing Habits and Health Utilization Outcomes. IDWeek 2022. Poster 909. Febrile Podcast. Episode #31 – Truth or DAIR. 2022 Feb 28. https://febrilepodcast.com/episode-31-truth-or-dair/ Frank JM, et al. The Mark Coventry, MD, Award: Oral Antibiotics Reduce Reinfection After Two-Stage Exchange: A Multicenter, Randomized Controlled Trial. Clin Orthop Relat Res. 2017 Jan;475(1):56-61. doi: 10.1007/s11999-016-4890-4. PMID: 27387759. Kelly MP, et al. Extended Oral Antibiotics Increase Bacterial Resistance in Patients Who Fail 2-Stage Exchange for Periprosthetic Joint Infection. J Arthroplasty. 2022 Aug;37(8S):S989-S996. doi: 10.1016/j.arth.2022.01.027. PMID: 35074446. Payne J, et al. Inducing Antimicrobial Resistance with Long-term Antibiotics at Stage 2 Revision for Periprosthetic Joint Infection. IDWeek 2022. Poster 981. Frost P, et al. Phototoxic potential of minocycline and doxycycline. Arch Dermatol. 1972 May;105(5):681-3. PMID: 5026677. Lode H, et al. Comparative pharmacokinetics of cephalexin, cefaclor, cefadroxil, and CGP 9000. Antimicrob Agents Chemother. 1979 Jul;16(1):1-6. doi: 10.1128/AAC.16.1.1. PMID: 475366. Sader HS, et al. In vitro activity of cefpodoxime compared with other oral cephalosporins tested against 5556 recent clinical isolates from five medical centers. Diagn Microbiol Infect Dis. 1993 Aug-Sep;17(2):143-50. doi: 10.1016/0732-8893(93)90025-3. PMID: 8243035. Green S & Tsai YV. Precision Dosing of To-Marrow: Linezolid Therapeutic Drug Monitoring. ContagionLive: Bench to Bedside with SIDP. 2022 Nov 3. https://www.contagionlive.com/view/precision-dosing-of-to-marrow-linezolid-therapeutic-drug-monitoring Check out our podcast host, Pinecast. Start your own podcast for free with no credit card required. If you decide to upgrade, use coupon code r-7e7a98 for 40% off for 4 months, and support Breakpoints. Check out our podcast host, Pinecast. Start your own podcast for free with no credit card required. If you decide to upgrade, use coupon code r-7e7a98 for 40% off for 4 months, and support Breakpoints.

Congratulations to Victoria Tam, PA-S, of Rutgers University! Victoria was one of two winners of the Susan Lindahl Memorial Scholarship, and she'll be presenting her paper next week at the annual PAOS conference on PJI. Stay tuned next week for an interview with our other scholarship winner - and the week after that we'll return to part 2 of our Skeletal Traction interview!

This podcast covers the JBJS January 19, 2022 issue. Featured are articles covering Cold Weather as a Risk Factor for Late Diagnosis and Surgery for DDH; recorded commentary by Dr. Wedge; Inflammatory Bowel Diseases Increase the Risk of Periprosthetic Joint Infection.

In this episode, Antonia and Andrew discuss a selection of articles from the January 19, 2022 issue of JBJS, along with an added dose of entertainment and pop culture. Listen at the gym, on your commute, or whenever your case is on hold! Articles Discussed: Predicting Anterior Cruciate Ligament Reconstruction Revision.A Machine Learning Analysis Utilizing the Norwegian Knee Ligament Register, by Martin et al. Patients Who Do Not Receive Aspirin Because of Allergy Have an Increased Risk of Venous Thromboembolism Following Total Joint Arthroplasty, by Goh et al. Effect of Sequential Intravenous and Oral Tranexamic Acid on Hemoglobin Drop After Total Knee Arthroplasty. A Randomized Controlled Trial, by Chang et al. Functional Outcome After Nonoperative Treatment of a Proximal Humeral Fracture in Adults, by Goudie et al. Predictors and Outcomes of Postoperative Hemoglobin of

In this episode, Marc and Mo are joined by special guest Javad Parvizi (James Edwards Professor of Orthopaedic Surgery at the Sidney Kimmel School of Medicine at the Rothman Institute at Thomas Jefferson University in Philadelphia) in a thought-provoking discussion on the goals and impact of international efforts to achieve consensus and standardization in orthopaedic care, with a specific focus on guidelines related to periprosthetic joint infection and venous thromboembolism. OrthoJOE Mailbag: feedback, comments, and suggestions from our audience can be sent to orthojoe@jbjs.org Links: Second International Consensus Meeting (ICM) on Musculoskeletal Infection. https://icmphilly.com/ Parvizi J, Gehrke T, Chen AF. Proceedings of the International Consensus on Periprosthetic Joint Infection. Bone Joint J. 2013 Nov;95-B(11):1450-2. https://online.boneandjoint.org.uk/doi/full/10.1302/0301-620X.95B11.33135?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org

Sir John Charnley said “joint sepsis will be the major hurdle in our way in the future”. His words are still valid. Periprosthetic joint infection is one of the most catastrophic complications in orthopedic surgery. Prevention is crucial. Join us for an interactive, lively and informative discussion regarding 2 of the most controversial intraoperative procedures to prevent PJI. Thinking BIG, two Bigs RCT of these issues will start in the future.Insights:Intraoperative Irrigation solutionsAntibiotic loaded cementKeynoteJoan Minguell MonyartHead of Orthopedic Surgery and Traumatology Service (COT) since 2016University Hospital Vall d’HebronBarcelona, SpainErnesto Guerra, MDConsultant Trauma and Orthopaedic SurgeryUniversity Hospital Vall d’HebronBarcelona, Spain

Javad Parvizi, MD, FRCS, Professor of Orthopaedic Surgery at Jefferson University and the Rothman Institute in Philadelphia discusses the assessment of periprosthetic joint infection. He talks about how he got interested in this field, why it is important, misconceptions held by many surgeons, how recent research is helping us better diagnose prosthetic joint infections, and […]

This podcast covers the JBJS issue for October 2019. Featured are articles covering Impact of Surgeon Volume and Training Status on Implant Alignment in TKA; recorded commentary by Dr. Randsborg; Surgical Versus Nonsurgical Management of Rotator Cuff Tears - A Matched-Pair Analysis; Patients with Type-1 Diabetes Are at Greater Risk of Periprosthetic Joint Infection; recorded commentary by Dr. Zhu; Tourniquet Use Does Not Affect Functional Outcomes or Pain After TKA.

This podcast covers the JBJS issue for October 2019. Featured are articles covering Impact of Surgeon Volume and Training Status on Implant Alignment in TKA; recorded commentary by Dr. Randsborg; Surgical Versus Nonsurgical Management of Rotator Cuff Tears - A Matched-Pair Analysis; Patients with Type-1 Diabetes Are at Greater Risk of Periprosthetic Joint Infection; recorded commentary by Dr. Zhu; Tourniquet Use Does Not Affect Functional Outcomes or Pain After TKA.

En el programa de esta semana (EP 158) seguimos hablando de infecciones de protesis articulares. Esta vez, en referencia al uso profiláctico de antibioticos y al riesgo de infecciones de protesis articular en asociación con bacteriemias.   Referencias: Centers for Disease Control and Prevention Guideline for the Prevention of Surgical Site Infection, 2017. JAMA Surg. 2017;152(8):784-791. doi:10.1001/jamasurg.2017.0904 Published online May 3, 2017. Corrected on June 21, 2017.  Proceedings of the International Consensus Meeting on Periprosthetic Joint Infection. 2013 Meeri Honkanene y colaboradores. Periprosthetic Joint Infections as a Consequence of Bacteremia. Open Forum Infect Dis. Mayo 2019. Rodriguez y colaboradores. Acute haematogenous prosthetic joint infection: prospective evaluation of medical and surgical management. Clin Microbiol Infect 2010; 16: 1789–1795. The use of prophylactic antibiotics prior to dental procedures in patients with prosthetic joints Evidence-based clinical practice guideline for dental practitioners—a report of the American Dental Association Council on Scientific Affairs. JADA Jan 2015. 145 (1): 11-16.   La Frase de la Semana: Esta semana nos valemos nuevamente de Benjamín Franklin. (1706-90) quien fue estadista, autor, editor, científico, inventor y diplomático. Nacio en una familia de pocos recursos en la ciudad de Boston y tuvo poca educación formal. Sin embargo, se hizo rico con un exitoso negocio de impresión en Filadelfia. Fue un participante muy activo en los asuntos públicos en Filadelfia, donde ayudó a lanzar una biblioteca, un hospital y una universidad (la Universidad de Pensilvania), y fue aclamado, entre otros proyectos, por sus experimentos con electricidad. Durante la Revolución Americana, sirvió en el Segundo Congreso Continental y ayudó a redactar la Declaración de Independencia en 1776. También negoció el Tratado de París de 1783 que puso fin a la Guerra de la Independencia (1775-83). En 1787, en su último acto significativo de servicio público, fue delegado a la convención que produjo la Constitución de los Estados Unidos. Como inventor ideo el pararayos, los lentes bifocales, y el catéter urinario flexible. La frase dice: “No habrá Justicia hasta que los que no se ven afectados estén tan indignados como los que están afectados”  

El tema de las infecciones de prótesis articulares es amplio y con diversas aristas. En el programa de esta semana en el podcast de Contagium hablamos del diagnostico de estas infecciones.    Referencias:   New Definition for Periprosthetic Joint Infection.  The Workgroup Convened by the Musculoskeletal Infection Society. J Arthroplasty 2011.  Diagnosis and Management of Prosthetic Joint Infection: Clinical Practice Guidelines by the Infectious Diseases Society of America. 2013. DIAGNOSIS AND PREVENTION OF PERIPROSTHETIC JOINT INFECTIONS
CLINICAL PRACTICE GUIDELINE . Adopted by the American Academy of Orthopaedic Surgeons Board of Directors. Marzo 2019. Proceedings of the International Consensus Meeting on Periprosthetic Joint Infection. 2013  Javad Parvizi  y colaboradores. The 2018 Definition of Periprosthetic Hip and Knee Infection: An Evidence-Based and Validated Criteria. J Arthroplasy 2018; 33: 1309-1314   La Frase de la Semana:   Esta semana la tomamos de uno de esos librosque nos hacen repensarnos y que en este casose trata de las enseñanzas en el salón de clase de Elie Wiesel escrito por Ariel Burger quien es escritor, maestro y rabino. Burger conoció a Wiesel a los 15 años de edad y fuesu amigo, alumno y asistente. El libro se titula Witness (Testigo) y fue publicado en el2018. Eliezer Wiesel 30 de septiembre de 1928 - 2 de julio de 2016) fueun escritor estadounidense de origen ruman,profesor, activista político, Premio Nobel, y sobreviviente del holocausto que escribió 57 libros, incluyendo Night, un trabajo basado en sus experiencias como prisionero judío en los campos de concentración de Auschwitz y Buchenwald. La frase dice: “Hegel dijo que las tragedias reales no son el conflicto entre el bien y el mal; Son conflictos entre dos derechos. Y hay una maravillosa enseñanza hasídica sobre eso quedice que cuando la gente no está de acuerdo,y cada uno jala hacia su lado, según su propia opinión, se crea un espacio entre ellos. Eneste espacio, se pueden crear mundos, siempre que los antagonistas no llenen ese espacio con demasiadas palabras. Es solo porque esas dos personas no están de acuerdo que existe o se crea tal espacio;Si estuvieran allí para mantener posiciones idénticas, no habría espacio para la innovación. En otras palabras, el conflicto puede ser bueno, si se hace bien”.    

This podcast covers the JBJS issue for April 2019. Featured are articles covering Plasma Fibrinogen Performs Better Than D-Dimer in Diagnosis of Periprosthetic Joint Infection; recorded commentary by Dr. Babis; Complications and Costs of Total Hip Arthroplasty and Hemiarthroplasty for Femoral Neck Fractures; Timing of Injections Prior to Arthroscopic Rotator Cuff Repair Impacts Surgical Site Infection; recorded commentary by Dr. Hasan; Compound Muscle Action Potential Amplitude Predicts the Severity of Cubital Tunnel Syndrome.

This podcast covers the JBJS issue for April 2019. Featured are articles covering Plasma Fibrinogen Performs Better Than D-Dimer in Diagnosis of Periprosthetic Joint Infection; recorded commentary by Dr. Babis; Complications and Costs of Total Hip Arthroplasty and Hemiarthroplasty for Femoral Neck Fractures; Timing of Injections Prior to Arthroscopic Rotator Cuff Repair Impacts Surgical Site Infection; recorded commentary by Dr. Hasan; Compound Muscle Action Potential Amplitude Predicts the Severity of Cubital Tunnel Syndrome.

This podcast covers the JBJS issue for July 2018. Featured are articles covering Percutaneous Needle Fasciotomy Versus Collagenase Treatment for Dupuytren Contracture; recorded commentary by Dr. Slater; Postoperative Glucose Variability Associated with Adverse Outcomes of Total Joint Arthroplasty; Risk-Based Hospital and Surgeon-Volume Categories for Total Hip Arthroplasty; recorded commentary by Dr. Vail; Alpha Defensin and C-Reactive Protein in the Diagnosis of Periprosthetic Joint Infection.

This podcast covers the JBJS issue for July 2018. Featured are articles covering Percutaneous Needle Fasciotomy Versus Collagenase Treatment for Dupuytren Contracture; recorded commentary by Dr. Slater; Postoperative Glucose Variability Associated with Adverse Outcomes of Total Joint Arthroplasty; Risk-Based Hospital and Surgeon-Volume Categories for Total Hip Arthroplasty; recorded commentary by Dr. Vail; Alpha Defensin and C-Reactive Protein in the Diagnosis of Periprosthetic Joint Infection.

This podcast covers the JBJS issue for September 2015. Featured are articles covering Twenty-Year Follow-up After Open Bankart Repair; Consumer Choice Between Hospital-Based and Freestanding Facilities for Arthroscopy - Impact on Prices, Spending, and Surgical Complications; recorded commentary by Dr. Singh; The Fate of Spacers in the Treatment of Periprosthetic Joint Infection; recorded commentary by Dr. Blumenfeld; Thromboembolism After Intramedullary Nailing for Metastatic Bone Lesions.

This podcast covers the JBJS issue for September 2015. Featured are articles covering Twenty-Year Follow-up After Open Bankart Repair; Consumer Choice Between Hospital-Based and Freestanding Facilities for Arthroscopy - Impact on Prices, Spending, and Surgical Complications; recorded commentary by Dr. Singh; The Fate of Spacers in the Treatment of Periprosthetic Joint Infection; recorded commentary by Dr. Blumenfeld; Thromboembolism After Intramedullary Nailing for Metastatic Bone Lesions.