JAMA Clinical Reviews: Interviews about ideas & innovations in medicine, science & clinical practice. Listen & earn CME credi

Deverick John Anderson, MD, MPH, professor of medicine at Duke University and director of the Duke Center for Antimicrobial Stewardship and Infection Prevention, discusses the evidence and appropriate strategies used in the prevention of surgical site infections with JAMA Associate Editor Anthony Charles, MD, MPH. Related Content: Surgical Site Infection Prevention

Anxiety disorders affect approximately a third of adults during their lifetime in the US and are associated with significant distress and impairment. JAMA Deputy Editor Mary M. McDermott, MD, discusses diagnosis and treatment of anxiety disorders with Naomi M. Simon, MD, MSc, professor of the Department of Psychiatry at NYU Grossman School of Medicine. Related Article(s):

Bacterial meningitis is a worldwide health problem causing approximately 300 000 deaths annually. In this podcast, JAMA Fishbein Fellow Revital Marcus, MD, speaks with Rodrigo Hasbun, MD, MPH, infectious disease specialist and professor of medicine at the University of Texas Health Science Center in Houston, about the epidemiology, diagnosis, and treatment of bacterial meningitis. Related Content: Progress and Challenges in Bacterial Meningitis Bacterial Meningitis

Rajesh T. Gandhi, MD, director of Harvard University's Center for AIDS Research, talks about recent advances in the treatment and prevention of HIV and discusses HIV in the context of COVID-19 and monkeypox infections. Hosted by JAMA Deputy Editor and Editorial Director for Equity Preeti Malani, MD, MSJ. Related Content: Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults Ending the HIV Epidemic Anthony Fauci, MD: Working to End HIV/AIDS

Phenome-wide association studies use large data sets to search for phenotypes associated with specific single-nucleotide variants, investigating whether specific genetic variations may be associated with multiple conditions and traits. In this podcast, JAMA Fishbein Fellow Revital Marcus, MD, discusses phenome-wide association studies with Dan M. Roden, MD, professor of medicine, pharmacology, and biomedical informatics at Vanderbilt University Medical Center, and Joshua C. Denny, MD, MS, chief executive officer of the National Institutes of Health's All of Us Research Program. Related Content: Phenome-Wide Association Studies

JAMA Interim Executive Editor Gregory Curfman, MD, interviews Robert M. Carey, MD, University of Virginia, about his review article on treatment of hypertension in the November 8, 2022, issue of JAMA. Their discussion addresses the clinical consequences of hypertension, as well as nonpharmacological and pharmacological approaches to management, including patients with resistant hypertension. Related Content: Treatment of Hypertension

JAMA Associate Editor Linda Brubaker, MD, MS, discusses medication abortion as an alternative to a procedural abortion to terminate a pregnancy in an interview with Stephanie Teal, MD, MPH, University Hospitals Cleveland Medical Center, and Rebecca Cohen, MD, OB/GYN, University of Colorado. Related Content: Medication Abortion Contraception Selection, Effectiveness, and Adverse Effects Conflict of Interest Disclosures: Dr Cohen serves as an unpaid board member for Cobalt, a reproductive rights advocacy group. No other disclosures were reported.

An estimated 45% of accredited US obstetrics and gynecology residency programs are located in states that currently ban or severely restrict abortions. JAMA Associate Editor Linda Brubaker, MD, and JAMA Internal Medicine Deputy Editor Deborah Grady, MD, speak with medical students, program directors, and other specialists in the ob-gyn training community about new restrictions and their effects on ob-gyn education in the US. Related Content: Implications of the Dobbs Decision for Medical Education Dobbs Decision Threatens Full Breadth of Ob-Gyn Training Medical Indications for Abortion Threats to Evidence-Based Care With Teratogenic Medications in States With Abortion Restrictions Treating Cancer in Pregnant Patients After Roe v Wade Overturned The Challenge of Emergency Abortion Care Following the Dobbs Ruling Clinical and Legal Dilemmas of Providing Reproductive Health Care After the Dobbs Decision Legal Risks and Ethical Dilemmas for Clinicians in the Aftermath of Dobbs The Implications of the Supreme Court Decision to Overturn Roe v Wade for Women With Pregnancy-Associated Cancers Reproductive Rights in Neurology—The Supreme Court's Impact on All of Us Antiabortion Laws and Implications for Patients With Cardiovascular Disease in Pregnancy Conflict of Interest Disclosures: Hannah Nguyen reported that she held leadership positions on Boston University's School of Medicine chapters of SPA-1 and DREAM. Margaux Zimmerman reported that she held leadership positions on Boston University's, School of Medicine chapters of ACOG and DREAM. Dr Gariepy reported that she was the Yale Complex Family Planning fellowship director from 2018 to March 2022, for which she received salary support from her institution; taught undergraduate and medical students, ob-gyn residents, and Complex Family Planning fellows; and is a research mentor for Complex Family Planning fellows who received research grants from the Society of Family Planning Research Fund. Dr Gariepy also reported leadership positions on the board of directors for the Society of Family Planning and the Complex Family Planning Fellowship Council and membership with Physicians for Reproductive Health, the National Abortion Federation, and the Society of Family Planning. Dr Steinauer is a member of the Society of Family Planning. Dr Loder reported that she serves as a principal investigator for contraceptive clinical trials for Merck and Sebela Pharmaceuticals Inc, consults for American Medical Students Association, and serves as program director for Complex Family Planning Fellowship, University of Michigan, Michigan Medicine. No other disclosures were reported.

Michele Bratcher Goodwin, JD (Center for Biotechnology and Global Health Policy, University of California, Irvine), Molly Meegan, JD (American College of Obstetricians and Gynecologists), and Lisa Harris, MD, PhD (University of Michigan) discuss how new abortion bans in the US are creating serious legal and ethical dilemmas for clinicians. Hosted by JAMA Legal and Global Health Correspondent Lawrence O. Gostin, JD (Georgetown University). Related Content: Legal Risks and Ethical Dilemmas for Clinicians in the Aftermath of Dobbs The Future of Ob-Gyn Training in the US Post-Dobbs Medical Indications for Abortion   Conflict of Interest Disclosures: Lawrence O. Gostin, JD, is the Legal and Global Health Correspondent for JAMA and Faculty Director of the O'Neill Institute for National and Global Health Law at Georgetown University.  No other disclosures were reported. Michele Bratcher Goodwin, JD, LLM, SJD is Director of the Center for Biotechnology and Global Health Policy at University of California, Irvine.  No other disclosures were reported.  Lisa Harris, MD, PhD, is the F. Wallace and Janet Jeffries Collegiate Professor of Reproductive Health, and Professor and Associate Chair in the Department of Obstetrics and Gynecology at University of Michigan. She is also a Professor in the Department of Women's Studies.  No other disclosures reported.  Molly Meegan is the Chief Legal Officer and General Counsel for the American College of Obstetricians and Gynecologists (ACOG).  No other disclosures reported.

Hypercalcemia affects approximately 1% of the population. Its presence typically indicates an underlying disorder and requires diagnostic evaluation. In this podcast, JAMA Associate Editor Anne Cappola, MD, ScM, interviews Elizabeth Shane, MD, an endocrinologist and professor of medicine at Columbia University Medical Center, about the clinical approach to diagnosing and managing hypercalcemia. Related Content: Hypercalcemia

In the US, pulmonary embolism (PE) affects approximately 370 000 patients annually and is estimated to cause 60 000 to 100 000 deaths per year. In this podcast, JAMA Senior Editor Kristin Walter, MD, MS, discusses the clinical presentation, diagnostic strategies, and treatment of PE with Yonathan Freund, MD, PhD, professor of emergency medicine at Sorbonne University in Paris, France. Related Article(s): Acute Pulmonary Embolism

Hyponatremia affects approximately 5% of adults and approximately 35% of hospitalized patients. Even mild hyponatremia can be associated with cognitive impairment; in hospitalized patients, hyponatremia is associated with longer hospital stays and increased mortality. In this podcast, JAMA Deputy Editor Mary M. McDermott, MD, interviews Nicolaos E. Madias, MD, a nephrologist and professor of medicine at Tufts University School of Medicine, about the clinical approach to diagnosing hyponatremia and management of both acute and chronic hyponatremia. Related Content: Diagnosis and Management of Hyponatremia

Myelodysplastic neoplasms, or myelodysplastic syndromes, are diagnosed in approximately 4 of 100 000 people each year in the US and are associated with a 5-year survival rate of approximately 37%. In this JAMA podcast and author interview, JAMA Deputy Editor Mary M. McDermott, MD, discusses the diagnosis and treatment of myelodysplastic syndromes with Mikkael A. Sekeres, MD, MS, chief of hematology and professor of medicine of the Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine. Related Content: Diagnosis and Treatment of Myelodysplastic Syndromes

JAMA Associate Editor Preeti Malani, MD, MSJ, discusses testing, treatment, and prevention of monkeypox infection and the current state of the 2022 outbreak with Carlos del Rio, MD, from Emory University's Department of Medicine. Recorded August 19, 2022. Related Content: Monkeypox in 2022—What Clinicians Need to Know What Is Monkeypox? What to Know About Monkeypox Global Monkeypox Outbreaks Spur Drug Research for the Neglected Disease Diagnosis, Prevention, and Treatment of Monkeypox Compassionate Use of Tecovirimat for the Treatment of Monkeypox Infection

JAMA Associate Editor Preeti Malani, MD, MSJ, discusses the transmission, diagnosis, and treatment of monkeypox and the 2022 outbreak with Jeannette Guarner, MD, and Carlos del Rio, MD, both of the Division of Infectious Diseases at Emory University's School of Medicine. Recorded July 11, 2022. Related Content: Monkeypox in 2022—What Clinicians Need to Know What Is Monkeypox? What to Know About Monkeypox Global Monkeypox Outbreaks Spur Drug Research for the Neglected Disease The WHO Declaration of Monkeypox as a Global Public Health Emergency Update on the Monkeypox Outbreak Update on Monkeypox (podcast)

Barrett esophagus affects approximately 5% of people in the US and approximately 1% worldwide; it's associated with an increased risk of esophageal adenocarcinoma. JAMA Deputy Editor Mary M. McDermott, MD, interviews Prateek Sharma, MD, a gastroenterologist and professor of medicine at University of Kansas School of Medicine, about the diagnosis, surveillance, and available therapy for patients affected by Barrett esophagus. Related Article(s): Barrett Esophagus

Malaria is diagnosed in approximately 2000 people in the US each year. Delay in diagnosis or inappropriate treatment of malaria is associated with increased mortality. In this podcast, JAMA Deputy Editor Mary M. McDermott, MD, interviews Johanna P. Daily, MD, MS, Albert Einstein College of Medicine, an infectious disease expert and scientist studying malaria, on the diagnosis, treatment, and prevention of malaria in the US. Related Content: Diagnosis, Treatment, and Prevention of Malaria in the US

Pregnancy inherently increases the risk of death, but certain conditions during pregnancy are considered life-threatening. In this podcast, JAMA Associate Editor Linda Brubaker, MD, discusses with maternal-fetal medicine specialists William A. Grobman, MD, The Ohio State University, and Cynthia Gyamfi-Bannerman, MD, MS, University of California, San Diego, the categories of life-threatening conditions, as well as the racial and ethnic disparities associated with pregnancy-associated mortality. Related Content: The Leaked Supreme Court Ruling Opinion What Overturning Roe v Wade May Mean for Assisted Reproductive Technologies in the US

In the US, approximately 100 000 people have sickle cell disease, a chronic condition characterized by hemolytic anemia, acute and chronic pain, increased rates of stroke and nephropathy, and an average lifespan that is 20 years less than that of the general population. In this podcast, JAMA Deputy Editor Mary McDermott, MD, interviews review article author Patricia Kavanaugh, MD, on the diagnosis and management of sickle cell disease. Discussion includes a summary of 3 new therapies for sickle cell disease and some of the social, structural, and cultural challenges encountered by patients with sickle cell disease. Related Content: Sickle Cell Disease

In July 2022, Kirsten Bibbins-Domingo, PhD, MD, MAS, took on a new role as the 17th editor in chief of JAMA and the JAMA Network. In conversation with Nobel laureate Harold Varmus, MD, Bibbins-Domingo discusses her research background, approaches to leadership in health care, and the critical role that journals play in communication about public health and science. Related Content: The Urgency of Now and the Responsibility to Do More—My Commitment for JAMA and the JAMA Network A Conversation With Dr Kirsten Bibbins-Domingo, JAMA's New Editor in Chief (video) A Conversation With Dr Kirsten Bibbins-Domingo, JAMA's New Editor in Chief (audio)

Carpal tunnel syndrome and trigger finger are common hand conditions in primary care practice that are associated with pain and disability. In this JAMA podcast, JAMA Deputy Editor Mary M. McDermott, MD, and Kelly Currie, MD, assistant professor in the Washington University Division of Plastic & Reconstructive Surgery in St Louis, Missouri, discuss the diagnosis and treatment of these conditions and other hand problems that are commonly encountered in primary care. Related Content: Common Hand Conditions Patient Information: Carpal Tunnel Syndrome

JAMA Associate Editor Ethan Basch, MD, and Melanie Calvert, PhD, from the University of Birmingham, UK, discuss barriers to and strategies for including rigorous patient-reported outcomes in clinical trials, and reflect on Dr Calvert's recent JAMA paper on related ethical implications. Related Content: Ethical Considerations for the Inclusion of Patient-Reported Outcomes in Clinical Research

JAMA Associate Editor Linda Brubaker, MD, MS, from University of California San Diego, discusses the implications of self-monitoring of blood pressure in higher-risk pregnancies with Richard J. McManus, MBBS, PhD, from University of Oxford, UK, and Lucy C. Chappell, MB BChir, PhD, from King's College London. Related Content: Effect of Self-monitoring of Blood Pressure on Diagnosis of Hypertension During Higher-Risk Pregnancy Effect of Self-monitoring of BP on BP Control in Pregnant Individuals With Chronic or Gestational Hypertension Management of Chronic Hypertension During Pregnancy Self-monitoring of Blood Pressure During Pregnancy

Lumbar spinal stenosis is a common cause of low back pain and disability in older people. Both nonoperative and operative therapies can improve symptoms from spinal stenosis. In this podcast, Jeffrey Katz, MD, MSc, from Harvard Medical School joins JAMA Deputy Editor Mary M. McDermott, MD, to discuss current evidence regarding diagnosis and optimal treatment of lumbar spinal stenosis, including when to consider invasive therapies for patients with symptoms of lumbar spinal stenosis. Related Content: Diagnosis and Management of Lumbar Spinal Stenosis

After certain adverse pregnancy outcomes, an individual's risk for cardiovascular and other diseases increases. JAMA Associate Editor Linda Brubaker, MD, discusses these complications as indicators of future health problems, who is at risk, and what can be done to improve health for at-risk individuals and populations with Lynn M. Yee, MD, MPH, and JAMA Senior Editor Philip Greenland, MD, from Northwestern University, and Eliza C. Miller, MD, MS, from Columbia University. Related Content: Mitigating the Long-term Health Risks of Adverse Pregnancy Outcomes To Prevent Cardiovascular Disease, Pay Attention to Pregnancy Complications

Pulmonary arterial hypertension is a rare condition that requires a thorough workup to evaluate for potential causes and right heart catheterization for definitive diagnosis and decision-making about treatment options. JAMA Associate Editor Kristin Walter, MD, MS, discusses the recent JAMA review article titled “Pulmonary Arterial Hypertension Classification, Diagnosis, and Treatment” with one of the authors, Nicole Ruopp, MD, assistant professor of medicine at Tufts Medical Center and Tufts University School of Medicine. Related Content: Diagnosis and Treatment of Pulmonary Arterial Hypertension

Epilepsy affects approximately 65 million people worldwide and is associated with increased rates of bodily injuries and mortality when not optimally treated. The primary goal of epilepsy treatment is to eliminate seizures while minimizing adverse effects of antiseizure drugs. JAMA Senior Editor Christopher Muth, MD, and Professor of Clinical Neurology at the University of Miami Miller School of Medicine Andres Kanner, MD, discuss establishing a diagnosis of epilepsy and the use of antiseizure medications for adult patients with epilepsy. Related Content: Treating Epilepsy With Antiseizure Medications A Review of Antiseizure Medications for Adults With Epilepsy

More than 200 000 individuals in the US develop acute cholecystitis annually. The majority of these cases are caused by gallstones blocking the cystic duct. However, about 5% to 10% of people with acute cholecystitis have acalculous cholecystitis. JAMA Associate Editor Kristin Walter, MD, MS, discusses the recent JAMA article “Acute Cholecystitis: A Review” with one of the authors, JAMA Associate Editor Anthony Charles, MD, MPH, who is Chief of the Division of Trauma, Critical Care and Acute Care Surgery, Director of the ECMO program, and Director of Global Surgery at University of North Carolina in Chapel Hill. Related Content: Acute Cholecystitis

Treatment strategies for acute ischemic stroke are continuing to evolve. JAMA Associate Editor and vascular neurologist Jeffrey Saver, MD, from the University of California Los Angeles, and JAMA Senior Editor Christopher Muth, MD, discuss 2 articles recently published in JAMA about alteplase in the treatment of acute ischemic stroke and provide a broader overview of the recent advances and future directions for the use of thrombolytics and endovascular thrombectomy for acute ischemic stroke.Treatment strategies for acute ischemic stroke are continuing to evolve. JAMA Associate Editor and vascular neurologist Jeffrey Saver, MD, from the University of California Los Angeles, and JAMA Senior Editor Christopher Muth, MD, discuss 2 articles recently published in JAMA about alteplase in the treatment of acute ischemic stroke, and provide a broader overview of the recent advances and future directions for the use of thrombolytics and endovascular thrombectomy for acute ischemic stroke. Related Content: Association of Recent Use of Non–Vitamin K Antagonist Oral Anticoagulants With Intracranial Hemorrhage Among Patients With Acute Ischemic Stroke Treated With Alteplase

Pregnant and recently pregnant individuals who become infected with the COVID-19 virus are at high risk of requiring extra medical care. JAMA Associate Editor Linda Brubaker, MD, MS, from University of California San Diego discusses the rapidly evolving data around COVID-19 and vaccine effectiveness and safety as it relates to pregnancy, breastfeeding, and fertility with 3 experts in the field: Laura E. Riley, MD, from Weill Cornell Medicine, Christina Chambers, PhD, MPH, from University of California San Diego School of Medicine-Pediatrics, and Denise Jamieson, MD, MPH, from Emory University. Related Content: COVID-19 and Pregnancy COVID-19 Vaccination During Pregnancy: Maternal Protection and Neonatal Immunity Widespread Misinformation About Infertility Continues to Create COVID-19 Vaccine Hesitancy Conflict of Interest Disclosures: Dr Chambers reported receiving research funding from Pfizer-BioNTech to study the safety of its COVID-19 vaccine in pregnancy. Dr Jamieson reported no disclosures. Dr Riley reported receiving compensation from UpToDate for work on several infections disease cards, receiving royalties from Turner Publishing, and serving on an advisory board for Maven. Dr Riley also reported serving on a CDC Advisory Committee on Immunization Practices workgroup on COVID-19 vaccines and vaccine safety and workgroups for the American College of Obstetricians and Gynecologists and Society for Maternal-Fetal Medicine of COVID-19 vaccination, without compensation.

Acute coronary syndromes are characterized by a sudden reduction in blood supply to the heart, and the syndromes include ST-segment elevation myocardial infarction (or STEMI), non-ST-segment elevation myocardial infarction (or NSTEMI), and unstable angina. Each year, an estimated more than 7 million people in the world are diagnosed with acute coronary syndromes, including more than 1 million people hospitalized in the US. In this podcast with Deepak L. Bhatt, MD, MPH, of Brigham and Women's Hospital Heart and Vascular Institute, we bring our listeners up-to-date on these common and potentially serious conditions. Related Content: Diagnosis and Treatment of Acute Coronary Syndromes

Tobacco smoking is responsible for more deaths in the US each year than any other preventable cause of mortality. Approximately 14% of US adults smoke cigarettes, of whom an estimated 70% want to quit smoking. JAMA Associate Editor Kristin Walter, MD, MS, discusses the recent JAMA article titled “Treatment of Smoking Cessation—A Review” with one of the authors, Nancy Rigotti, MD, who is director of the Tobacco Research and Treatment Center at Massachusetts General Hospital and is a professor at Harvard Medical School. Related Content: Treatment of Tobacco Smoking

Multiple myeloma is a hematologic malignancy characterized by abnormal plasma cells in the bone marrow, with potential uncontrolled growth causing destructive bone lesions, kidney injury, anemia, and hypercalcemia. Edward Libby, MD, of the University of Washington, joins JAMA Associate Editor Ethan Basch, MD, of the University of North Carolina, for a discussion of the diagnosis, complications, and management of myeloma, as well as the related conditions of monoclonal gammopathy of undetermined significance (MGUS) and smoldering myeloma. Related Content: Diagnosis and Management of Multiple Myeloma Patient Information: Multiple Myeloma

Approximately 1 in 5 adults in the US had a sexually transmitted infection in 2018. Khalil Ghanem, MD, PhD, of Johns Hopkins University joins JAMA Deputy Editor Mary McDermott, MD, to discuss the newest recommendations regarding the diagnosis and treatment of sexually transmitted infections, including gonorrhea, chlamydia, syphilis, Mycoplasma genitalium, and trichomoniasis. Related Content: Diagnosis and Treatment of Sexually Transmitted Infections

Pulmonary nodules are commonly found on lung imaging studies. Evaluation and management depends on the size and other characteristics of pulmonary nodules and patient risk factors for malignancy. JAMA Associate Editor Kristin Walter, MD, MS, discusses the recent JAMA article “Evaluating the Patient With a Pulmonary Nodule: A Review” with one of the authors, Peter Mazzone, MD, MPH, a pulmonologist and director of the Lung Cancer Program for the Respiratory Institute at the Cleveland Clinic. Related Content:

The last few years have seen a tremendous increase in the conduct of platform clinical trials, a type of randomized clinical trial that can simultaneously evaluate the effects of multiple interventions, often in combination, with the available treatments changing over time as more is learned about their effectiveness. Jay J.H. Park, PhD, and Edward J. Mills, PhD, from the University of British Columbia and McMaster University, respectively, join JAMA Statistical Editor Roger J. Lewis, MD, PhD, to discuss how clinicians should evaluate the results of platform clinical trials when considering incorporating the results into their clinical practice. Related Content: How to Use and Interpret the Results of a Platform Trial

Approximately 87% of US women will use contraception during their lifetime. Stephanie Teal, MD, MPH, from University Hospitals Cleveland Medical Center, and JAMA Associate Editor Linda Brubaker, MD, MS, from University of California San Diego, discuss factors to consider during contraception selection, balancing highest effectiveness and lowest risks. Related Content: Contraception Selection, Effectiveness, and Adverse Effects

Nearly all pregnant individuals use at least 1 medication, either prescribed or over-the-counter, during their pregnancy. Denise Jamieson, MD, MPH, professor and chair of Gynecology and Obstetrics at Emory University in Atlanta, Georgia, joins JAMA Associate Editor Linda Brubaker, MD, MS, to discuss the current FDA system and other resources for communicating medication safety data to clinicians. Related Content: Assessment of the Safety of Common Medications Used During Pregnancy

Appendectomy remains the first-line therapy for acute appendicitis, but treatment with antibiotics rather than surgery is appropriate in selected patients with uncomplicated appendicitis. JAMA Associate Editor Anthony Charles, MD, MPH, from UNC School of Medicine summarizes this and other aspects of acute appendicitis in adults along with author Theodore N. Pappas, MD, from Duke University Medical Center. Related Content: Diagnosis and Management of Acute Appendicitis in Adults Acute Appendicitis

Acne vulgaris is one of the most common skin disorders seen in the outpatient clinic setting. Lawrence F. Eichenfield, MD, of the University of California San Diego School of Medicine, joins JAMA Dermatology Web/Associate Editor Adewole S. Adamson, MD, MPP, to discuss the latest developments in the evaluation and management of acne vulgaris and answer common questions related to acne subtyping, treatment selection, medication side effects, and diet. Related Content: Management of Acne Vulgaris Patient Information: Acne Treatment

Iron deficiency anemia can be caused by either decreased iron availability or increased iron requirements after blood loss from the gastrointestinal (GI) tract. Nabil M. Abou Baker, MD, and Andrew M. Davis, MD, MPH, both of the University of Chicago, join JAMA Deputy Editor Michael Berkwits, MD, MSCE, to discuss the evaluation of iron deficiency anemia and 2020 AGA recommendations for the workup of GI causes, including revised thresholds for ferritin values and the use of upper and lower (bidirectional) endoscopy. Related Content: Gastrointestinal Evaluation of Iron Deficiency Anemia

Romina Brignardello-Petersen, DDS, PhD, and Gordon Guyatt, MD, of McMaster University talk with JAMA Executive Deputy Editor Robert Golub, MD, about how to interpret clinical practice guidelines and recommendations, the subject of a recent Users' Guides to the Medical Literature article in JAMA. Related Content: How to Interpret and Use a Clinical Practice Guideline or Recommendation