POPULARITY
3 episodes with early onset
3 episodes with early onset
2 episodes with early onset
2 episodes with early onset
2 episodes with early onset
2 episodes with early onset
2 episodes with early onset
2 episodes with early onset
2 episodes with early onset
Jordan & Cian Adams, known as the FTD Brothers, join Ger, Enda & Dara on the show in the midst of their 33-day challenge, running a marathon every day as they travel the country.The lads are fundraising for the FTD Brothers Foundation CIC & Alzheimer Society of Ireland. Their Irish mother, Geraldine, was diagnosed with ‘Early-Onset' Frontotemporal Dementia in 2010, sadly passing away in 2016, at the age of 52.The two boys have tested for a genetic fault/mutation of the MAPT gene, meaning they would also develop the same illness as their mother.Catch The Off The Ball Breakfast show LIVE weekday mornings from 7:30am or just search for Off The Ball Breakfast and get the podcast on the Off The Ball app.SUBSCRIBE at OffTheBall.com/join
As wellness trends evolve across coastal communities, a shocking public health crisis is emerging among young adults facing early-onset metabolic disease. We sit down with leading health experts to discuss how modern lifestyle choices, childhood obesity, and environmental toxins are fueling an unprecedented rise in youth cancer rates. Learn how premium proactive healthcare, preventative screening matrices, and clean-eating habits can safeguard your family's long-term vitality.
Jeremy Zakis reports on the early onset of a dry El Niño cycle in Australia, causing unusually cold temperatures and preventing typical fall storms. This dry air dissipated a potential cyclone but raised concerns about a catastrophic summer and early bushfire risks, prompting preemptive back-burning. Meanwhile, the Middle East crisis has spiked petrol prices to record highs, with Australian costs reaching $8–$9 per gallon, as the government advises fuel-saving measures such as using public transit and maintaining tire pressure to avoid formal rationing. (1)1943 DARWIN
Early-onset cancers are rising—and they're forcing people to rethink cancer, screenings and care models.What if cancer care strategy needs to start earlier—and last longer? This Pharmacy Friends conversation breaks down the rise in early-onset cancers and the practical implications for prevention, benefit design, and affordability.00:00 Intro02:30 Basics of cancer in younger people07:52 Early onset cancer impact on health plans11:14 Patient challenges and decision making15:23 Impact on affordability22:00 Importance of medical and pharmacy benefit integration 27:38 New ways of offering cancer care30:41 Role that AI can play in patient care33:26 Should health care adapt for best clinical outcomes34:50 Being an advocate for the patient38:49 ClosingContent in this podcast is for informational or educational purposes only. The content also does not substitute professional medical advice or consultations with health care professionals. Always seek advice from a physician or other health care providers with any questions you have regarding a medical treatment or condition before undertaking a new health care regimen.
In this special live episode recorded during Colorectal Cancer Awareness Month, she sits down with Kevin Conroy, CEO of Exact Sciences and the force behind Cologuard; Judy Faulkner, founder and CEO of Epic Systems; and epidemiologist Dr. Caitlin Murphy to dig into why this disease keeps striking younger people. They cover the leading theories like ultra-processed foods, microplastics, the microbiome and debate whether the screening age should drop below 45, and get into the symptoms doctors too often brush off. If you know someone in their 30s or 40s, send them this one. It could save a life.See omnystudio.com/listener for privacy information.
In this episode of Longevity by Design, host Dr. Gil Blander sits down with Dr. Terrie Moffitt, University Professor at Duke University. They explore the deep link between mental health, self-control, and the pace of biological aging, showing how early-life mental disorders can shape health decades later.Terrie describes her work with the decades-long Dunedin study, which tracks health from birth through midlife. She explains how people age at different rates, even when born in the same year and place, and how the “pace of aging” can be measured using biomarkers. Terrie shares that fast agers show early signs of physical and cognitive decline, while those with strong self-control tend to experience better health, stronger relationships, and greater financial stability as they grow older.The discussion reveals that treating mental health issues early in life could prevent chronic diseases and slow aging itself. Terrie makes a strong case for taking mental health seriously, both as prevention and as a path to a longer, healthier life. Guest-at-a-Glance
Send a textOn this episode of Going Under: Anesthesia Answered with Dr. Brian Schmutzler, why Early-Onset Cancer Is Rising In The United States.Colon cancer at 40 should stop you in your tracks, and it's becoming less of a rarity. We're seeing more aggressive cancers diagnosed in younger adults across the US, and we wanted to talk about what's changing, what we actually know, and what you can do before symptoms ever show up.Have a question for Dr. Brian Schmutzler? Submit them to any of the social media pages below or on his website at https://www.drbrianschmutzler.com/Facebook: https://www.facebook.com/drbrianschmutzlerInstagram: https://www.instagram.com/drbrianschmutzlerTikTok: https://www.tiktok.com/@drbrianschmutzler?lang=enProvider or Medical Student?? Subscribe to his Patreon Page to get exclusive content and access to Medical Blocks:https://www.patreon.com/user?u=89356957&utm_medium=clipboard_copy&utm_source=copyLink&utm_campaign=creatorshare_creator&utm_content=join_linkThanks to our show sponsor: Butterfly Networkhttps://store.butterflynetwork.com/us/en/?rsCode=BRIAN25Get $750 off the latest iQ3 at ButterflyNetwork.comSupport the show
We have all seen the unfortunate headlines. Why are we seeing a rise of early-onset colorectal cancer and what can we do about it? Dr. Barnell, co-founder and CMO of Geneoscopy, joins the Gut Doctor Podcast to answer these questions and more!
Pippa Hudson speaks to Dr. Fatima Hoosain who is a specialist surgeon with the practice Appfelstedt Hoosain and Associates about early onset cancer treatments. Lunch with Pippa Hudson is CapeTalk’s mid-afternoon show. This 2-hour respite from hard news encourages the audience to take the time to explore, taste, read and reflect. The show - presented by former journalist, baker and water sports enthusiast Pippa Hudson - is unashamedly lifestyle driven. Popular features include a daily profile interview #OnTheCouch at 1:10pm. Consumer issues are in the spotlight every Wednesday while the team also unpacks all things related to health, wealth & the environment. Thank you for listening to a podcast from Lunch with Pippa Hudson Listen live on Primedia+ weekdays between 13:00 and 15:00 (SA Time) to Lunch with Pippa Hudson broadcast on CapeTalk https://buff.ly/NnFM3Nk For more from the show go to https://buff.ly/MdSlWEs or find all the catch-up podcasts here https://buff.ly/fDJWe69 Subscribe to the CapeTalk Daily and Weekly Newsletters https://buff.ly/sbvVZD5 Follow us on social media: CapeTalk on Facebook: https://www.facebook.com/CapeTalk CapeTalk on TikTok: https://www.tiktok.com/@capetalk CapeTalk on Instagram: https://www.instagram.com/ CapeTalk on X: https://x.com/CapeTalk CapeTalk on YouTube: https://www.youtube.com/@CapeTalk567 See omnystudio.com/listener for privacy information.
Welcome to Season 2 of the Orthobullets Podcast.Today's show is CoinFlips, where expert speakers discuss grey zone decisions in orthopedic surgery. This episode will feature doctors Jaime Gomez, Craig Louer, Ryan Fitzgerald, & Chris Hardesty. They will discuss the case titled "Early Onset Scoliosis in 20-month-old Female."Follow Orthobullets on Social Media:FacebookInstagramTwitterLinkedInYouTube
Colorectal cancer is rising in younger adults, with U.S. rates increasing 2.4% per year since 2012. New evidence points to dietary changes as a contributing factor A recent study in JAMA Oncology found that those consuming the most ultraprocessed foods had a 45% higher risk of developing precancerous colorectal tumors before age 50 Risk increased with higher ultraprocessed food intake, then plateaued beyond seven to eight servings daily. Sweetened beverages, sauces, spreads, and condiments showed the strongest links You can reduce ultraprocessed food intake by planning real meals, replacing snack foods with whole ingredients, tracking triggers, and making unprocessed options more visible and accessible in your home Lowering your linoleic acid intake, increasing fiber gradually, and supporting gut health with protective foods and habits also helps reduce your risk of colorectal cancer
Hello and welcome to the latest episode of OCTalks, the podcast series from Oncology Central. I am Jade Parker, Senior Editor of Oncology Central. Today I am joined by Leanne Bailey who is Branch Director of the Community Outreach Research and Engagement branch of the NCI's Center to Reduce Cancer Health Disparities. In this interview, we will discuss contributing factors to early onset cancers, how are certain groups disproportionately affected and initiatives that are seeking to reduce disparities in cancer care. Thank you for joining us, LeeAnn.
In this episode, we review the high-yield topic of Other Early Onset Disorders from the Psychiatry section.Follow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets
A recent recipient of a coveted Marsden grant to research early-onset Parkinson's was diagnosed with the disease herself, age 41.
11-07-25 - Vincent Emails In The He Was Just Diagnosed w/Early Onset Alzheimers - Someone Thought John Was Doug Hopkins' Son At The RaRa Room - Guys Odd Guest At Suns Game - Antonio Brown Arrested In Dubai For Attempted MurderSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
11-07-25 - Vincent Emails In The He Was Just Diagnosed w/Early Onset Alzheimers - Someone Thought John Was Doug Hopkins' Son At The RaRa Room - Guys Odd Guest At Suns Game - Antonio Brown Arrested In Dubai For Attempted MurderSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Guest: Joel Gabre, M.D, MPH On this episode of Advances in Care, host Erin Welsh and Dr. Joel Gabre, a gastroenterologist at NewYork-Presbyterian and Columbia who specializes in cancer care, discuss the ongoing rise in colorectal cancer rates among younger individuals. Dr. Gabre lays out trends observed by the medical community in colorectal cancer rates, including the increasing likelihood by birth cohort for patients to develop this disease. He also talks about the main differences in colorectal cancer for patients from these different cohorts, most notably the location where cancers are likely to develop in the colon. In addition, Dr. Gabre shares some of the leading hypotheses for why colon cancer rates are rising in younger people, and how clinicians and researchers are focused on searching for answers to improve prevention and treatment options. He gets into the importance of the western diet in developing these forms of cancer and shares details about his team's recent findings regarding changes at the cellular level that could be contributing to the accelerated growth of these cancers. Finally, Dr. Gabre speaks to his personal experiences as a gastroenterologist who has seen first-hand the rise in colon cancer rates among his younger patients. He shares a story of what …
More young people under the age of 50 are getting diagnosed with early-onset cancers and researchers are trying to figure out why. Nina Agrawal, health reporter for The New York Times, explains what they have found so far, and what is still unknown.
Join us as we sit down with Marisa Peters, a colorectal cancer survivor and passionate advocate, to hear her inspiring journey through diagnosis, treatment, and life after cancer. Marisa shares how she navigated the challenges of managing a career, raising a family, and adapting to the evolving landscape of cancer care. This episode offers heartfelt insights for both patients and caregivers on staying resilient, finding support, and embracing life beyond cancer. For more resources, click the links below. https://beseen.care/ https://www.uspreventiveservicestaskforce.org/uspstf/recommendation/colorectal-cancer-screening https://www.instagram.com/fromcarpoolstochemo/ https://wvmountainsofhope.org/ https://fightcolorectalcancer.org/
Annmarie O'Connor spoke to Matt about her book Twitch. Diagnosed at the age of 48, the book details Annmarie's experience of living with Parkinson's Disease.Having worked as a fashion editor and stylist, Annmarie spoke about coming to terms with the disease and how she has learned to adapt to live a quieter life. To catch the full conversation, press the 'play' button on this page.
In today's episode, we had the pleasure of speaking with Evelyn Y. Wong, MD, about the growing challenge of early-onset colorectal cancer (CRC) and the insights from a recent cohort analysis conducted in Singapore. Dr Wong is a consultant medical oncologist specializing in gastrointestinal cancers at the National Cancer Centre Singapore. In our exclusive interview, Wong discussed the rationale for investigating early-onset CRC, emphasizing the rising incidence worldwide and the need to better understand whether unique molecular or survival patterns distinguish these patients from those with late-onset disease. She reviewed data from approximately 2500 patients in a consented Singaporean cohort, highlighting that molecular characteristics were largely consistent across age groups, but survival outcomes appeared more favorable in younger patients, potentially due to their ability to tolerate more intensive therapies. Additionally, Wong underscored the importance of multicenter and international collaborations to strengthen these findings and advance prospective studies that can more precisely connect molecular features with environmental exposures and epidemiologic drivers. She also emphasized the role of increasing awareness among clinicians, researchers, pharmaceutical partners, and patient advocates to ensure that the unique needs of younger patients with CRC are addressed within the broader oncology community.
Dr. Sumanta (Monty) Pal and Dr. Kimmie Ng discuss the disturbing rise of early-onset gastrointestinal cancers, the unique challenges faced by younger patients, and key research that is shedding light on potential drivers of early diagnoses in colorectal cancer. TRANSCRIPT Dr. Sumanta (Monty) Pal: Hello, everyone. I'm Dr. Monty Pal, and I'm a medical oncologist and professor and vice chair of medical oncology at the City of Hope Comprehensive Cancer Center in Los Angeles. I'm really delighted to welcome you all to the ASCO Daily News Podcast as the show's new host. I'll be bringing you discussions with leaders in the oncology space on a variety of topics. I've been working hard with the ASCO team on picking the ideal topics to bring to you, and I'm really delighted to introduce my first guest, a dear friend, Dr. Kimmie Ng, to discuss this huge problem that we're seeing nowadays of early-onset GI cancers. Dr. Ng is the associate chief of the Division of Gastrointestinal Oncology at the Dana-Farber Cancer Institute, and she's an associate professor of medicine at Harvard Medical School in Boston. She serves as co-director of the Colon and Rectal Cancer Program. She's also the founding director of the Young-Onset Colorectal Cancer Center at Dana-Farber. I'm sure we'll talk a little bit about that today. Just to note, our full disclosures are available in the transcript of this episode. Dr Ng, it's so great to have you on the podcast. Thanks so much for joining us. Dr. Kimmie Ng: Thank you so much for having me. It's great to be here. Dr. Sumanta (Monty) Pal: I'm going to refer to you as Kimmie, if you don't mind, for the rest of the podcast here. Please, we'll go by first names, if you don't mind. Your research has really done so much to help improve our understanding of early-onset GI cancers. You've done a lot of work to increase awareness in this space. I don't think there's a couple of months that passes by when I don't see you on television on Good Morning America or other shows really broadcasting this really critical message. I think there's a certain sensitivity that we all have to this issue, right? I mean, because receiving a cancer diagnosis at any age is very challenging, but I'm sure that young patients who face a colorectal cancer diagnosis have some very unique challenges. Could you give us a sense of some of those? Dr. Kimmie Ng: I think the other reason why so many people are interested in this and feel touched by this is that it's not just gastrointestinal cancers that are increasing in young people, but actually a multitude of different cancers have been rising in young individuals. And while it is difficult at any age to receive a cancer diagnosis, we do all know that young people getting a diagnosis like this do face unique challenges. Studies have shown that over 80% have children under the age of 18 when they are diagnosed with colorectal cancer, for example, under the age of 50. And many experience career and education disruptions. They are in what we call the ‘sandwich generation,' where they're not only taking care of young families or starting to think about starting a young family, but they're also taking care of elderly parents. So it's just a very busy stage of life, and to then be facing a usually terminal cancer diagnosis, it is extremely challenging. The other factors that we've seen that seem to be unique or more prevalent in young patients is that there are higher levels of psychosocial distress, depression, and anxiety, and a majority of patients do need medical attention and treatment for those things, whether it's medication treatment or whether it's counseling or support from psychosocial oncologists. And so the other big issue is fertility. We know that so many of the treatments that these young patients receive do permanently and negatively impact fertility. And for a person who is young, who may still be trying to expand their family or again start a family, it is very important that these young patients do receive counseling about fertility preservation prior to starting treatment. Dr. Sumanta (Monty) Pal: You know, it's so interesting you bring this up, and I think about a patient who's in their 40s diagnosed with this disease. They're in the same demographic as I am, as you are. You know, I'm 44 years old, and you know, I'm thinking about my 11- and 12-year-old and my aging parents, right? I mean, the dilemmas that you highlighted are precisely what I'm facing in life, and it's so true, right? If I had to take my day-to-day and superimpose on that a colorectal cancer diagnosis, it would just be problematic in so many spheres, so many spheres. Dr. Kimmie Ng: Absolutely. And because we did think going into this, starting our Young-Onset Colorectal Cancer Center, that these patients will need unique supports, we did conduct a qualitative study and held some focus groups of young-onset colorectal cancer patients as well as their caregivers. And we really identified four primary themes that I think reflect a lot of the experience of patients with cancer, no matter what type of cancer when they're diagnosed young. And the first is the need, feeling overwhelmed by the healthcare system, and the need for patient navigation. As we know, a lot of these patients are previously healthy before they're facing this very serious diagnosis. The second is the need for peer-to-peer support, where they really value connecting with other young patients going through a similar experience. The third, we talked about already, the need for kind of formal psychosocial support in the form of psychosocial oncologists or psychiatrists or social workers. And the last is an interest in research. They are really very invested in getting germline genetic testing as well as somatic genomic profiling to help guide their therapy. Dr. Sumanta (Monty) Pal: That's really encouraging to hear that they themselves are interested in participating in research. I mean, obviously, that's a great way to move the field forward. I view your area of work here as being such a vexing problem because no matter what way you slice it, young-onset colorectal cancer still remains a relatively small proportion of all diagnoses. So how do you go about studying this phenomenon? I mean, it must be challenging to really sort of investigate underlying causes when ostensibly this is still a small piece of the pie. Dr. Kimmie Ng: That is such a great question and is one of the challenges me and my research team think about every single day. As you mentioned, one of the major barriers is that although these cancers are rising in young people, the absolute number of patients being diagnosed is still relatively small, and if it's going to take large scale epidemiologic studies to really understand, for example, what the dietary and lifestyle risk factors are, you need a considerable number of patients in order to have enough power to reach definitive conclusions. And so this is where it is so important to collaborate. Any single institution is not going to see enough young-onset patients with colorectal cancer to be able to do this work on their own. And so I have really been intent on establishing an international prospective cohort study of patients with young-onset colorectal cancer so that we can increase the numbers of patients we partner with to try to answer these questions, but also so that we can study this on a global scale, because unfortunately this is not something that's just plaguing the United States. It is actually happening in multiple countries around the world. So that is one barrier. The second, I would say, is that we think it's early life exposures to whatever environmental factor it is that's causing the rise that is likely contributing the most. And so if you imagine how difficult it would be to start studying individuals from when they're children through adolescence, through adulthood, and then all the way until a cancer diagnosis is obtained, a study like that would take too long, would cost too much, and really wouldn't be feasible. So we need to think of alternative ways to really try and answer this question of what is driving this rise in young-onset colorectal cancer. Dr. Sumanta (Monty) Pal: Honestly, Kimmie, this seems like almost an unfair question in the context of what you just mentioned, the challenges in terms of ascertaining causality, right? I'll tell you, I cheated a little bit ahead of this podcast. Kimmie and I had dinner together in Los Angeles a couple months ago. She came out to deliver a Presidential Lectureship at City of Hope. We were delighted to have her. And we did have a couple of thoughts exchanged over potential drivers of these early diagnoses, leaning on perhaps one of the things that you and I are both interested in, the microbiome. But amongst all these things, vitamin D, microbiome, etc., and I won't hold you to this, do you have at least a general sense of what might be contributing to this early-onset phenomenon? Dr. Kimmie Ng: Yeah, as we talked about during my visit there to City of Hope, we do hypothesize that it is a complex interaction between our exposome, which is everything we are exposed to in our environment, which does include diet and lifestyle factors, interacting with host immunity and antitumor immunity, and as well as the microbiome and shaping the composition and diversity of the gut microbiome that are likely interacting to increase susceptibility to colorectal cancer at a younger age. And I will say one of the biggest discoveries, if you will, about what might be driving young-onset colorectal cancer was published a few months ago in Nature. And that paper identified a specific mutational signature caused by the genotoxin colibactin, which is often produced by an organism called pks+ E. coli, as being much more prevalent in younger patients with colorectal cancer than older patients. And so while it doesn't explain necessarily all of young-onset colorectal cancer and why it's rising, it does give us a clue that the microbiome is likely very important in perhaps why this is rising in young people. Dr. Sumanta (Monty) Pal: After you mentioned it, I went back and dove deep into that paper. I was fascinated, fascinated by the content there. And this is just a massive exploration across thousands of patients worldwide. So, I mean, if there is a way to get at least some hint of what's driving this phenomenon, I suppose that's it. So thank you for pointing me in the direction of that manuscript. Now that we've addressed the issue of diagnosis, if we could just, you know, verge on the topic of treatment, right? And this is something that I struggle with. When I have my young patients with kidney cancer, I don't know necessarily that my treatment paradigm changes a whole heck of a lot. I guess what I will say is I might be a little bit more aggressive about concepts like definitive management with surgery. I suppose perhaps their treatment tolerance is a little bit higher. But tell us about the setting of young-onset colorectal cancer. Is the philosophy any different in terms of the actual sort of management of these patients? Dr. Kimmie Ng: That's a great question, and actually I was honored to participate in the first international consensus guidelines group to try to come up with uniform recommendations for how to treat young patients with colorectal cancer. And you know, the overall consensus is just as you said, the medical care of these young patients right now is really not that much different than that of an older patient with colorectal cancer. There are a couple of distinctions. One is that all young patients should get germline genetic testing, given that there is a higher prevalence of pathogenic germline variants when you are diagnosed at a young age. And the second is what we've already talked about, which is that all young patients should be referred for counseling about fertility preservation prior to starting treatment. But otherwise, the chemotherapy regimens recommended, you know, surgery, radiation, all of that seems very similar to older patients. I will say that because most of our young patients with colorectal cancer are diagnosed with left-sided cancers, including rectal cancers, where some of the treatment may be morbid and result in lifelong complications, we do consider de-escalation of therapy and try to consider the long-term implications when it's safe to do so and won't compromise outcomes. The other concerning thing is that younger patients don't necessarily have a better prognosis than older patients. And multiple studies have shown this, that even though we both often treat younger patients more aggressively – they more often receive multi-agent chemotherapy, and more often undergo surgery and radiation – their survival is not necessarily correspondingly better than an older patient with colorectal cancer. So that suggests to us that maybe these cancers are indeed biologically different and perhaps more aggressive or perhaps less responsive to treatment. And so that is some of the focus of our research too, to understand what is actually different about these cancers and how they respond to treatment. Dr. Sumanta (Monty) Pal: It's such a paradox, isn't it, right? Because you just brought this to my mind. I guess on the one hand, our younger patients may be able to tolerate perhaps a greater amount of chemotherapy, targeted therapy, etc. But you're absolutely right. I mean, they do sort of have these lingering issues with side effects that may persist for much longer than the 80- or 90-year-old that we're treating in the clinic. I mean, these tend to be sort of lifelong consequences and sequelae that they're dealing with. So that really does evolve to be a challenge. You've kind of changed my mindset there a little bit. Dr. Kimmie Ng: Yeah, I do think survivorship issues and long-term complications of therapy do need to be considered, especially for a young person who we hope will live a very, very long time. And so part of the work that our Young-Onset Colorectal Cancer Center is doing, we are participating in a pilot navigation study where we navigate patients to survivorship earlier than we typically would, perhaps, for an older patient. And that's so we can get a head start on addressing some of those potential complications of therapy and hopefully mitigate them so that they don't become an issue long term. Dr. Sumanta (Monty) Pal: Do you think there's a role for de-escalation studies formally in these young populations of patients? Dr. Kimmie Ng: I think de-escalation studies are important overall, and specifically for locally advanced rectal cancer, which again is one of the most common types of colorectal cancer diagnosed in our young patients, there are certain populations that may be able to forgo the radiation treatment to the pelvis, for example, and there's more and more patients who now may become candidates for non-operative management where they may not necessarily need to have their rectal cancer surgically removed. And elimination potentially of both of those modalities of treatment can really avoid some of the most serious and morbid complications that often occur with these treatments. Dr. Sumanta (Monty) Pal: Really interesting. Now, this is not and will never be a political podcast, but you know, obviously we're dealing with the consequences of changes on funding and so forth that have evolved over time. And I think it's worth sort of speculating how the landscape of research may change on account of that. Could you comment perhaps a little bit on how some of the funding cuts that we've seen recently at the NIH might affect the body of work that you're so integrally involved in? Dr. Kimmie Ng: I am honestly very worried about the current funding environment. Colorectal cancer is the third most commonly diagnosed cancer among men and women in the United States and globally, and when you combine men and women together, the second leading cause of cancer death. But proportionally, we receive much less funding for colorectal cancer compared to other cancer types. And my thoughts have always been that perhaps this is because there is this stigma around colorectal cancer and maybe some of the symptoms associated with colorectal cancer. And so on top of that, to have additional challenges in obtaining funding, I worry what it will do to the pace of progress for especially young patients with this disease. Also, because of some new stipulations that perhaps international collaborations are being discouraged, I also worry about that aspect of it because young-onset colorectal cancer and gastrointestinal cancers in general is a global phenomenon happening in multiple countries around the world. And if we are to understand what the environmental factors are affecting the different rates of rise in these different countries, we do so much need that international collaboration. So yes, I am worried, and I do hope that conversations like this will spark an awareness of the need for more funding and continued funding into this disease. Dr. Sumanta (Monty) Pal: I will say that, and the audience can't see this because this is an audio program, but I'm wearing my Southwest Oncology shirt here, a SWOG, and it's one of the National Cancer Institute-funded cooperative groups. And you know, I was recently dismayed to find that, you know, funding got cut for international collaborations and enrollment in South America and Latin America. And this was traditionally actually a mainstay of our enrollment for many trials, including trials in rare cancers that present themselves in younger patients in the GU space. So, I completely agree with you. We've got to do something to address this funding issue to make sure that this body of work, both yours and mine, continues, without a doubt. Kimmie, this has been a delightful conversation. I really want to thank you for, you know, leading the charge in the young-onset colorectal cancer space, and you've done so much tremendous work here. Dr. Kimmie Ng: Thank you for having me. Dr. Sumanta (Monty) Pal: If you value the insights that you hear on the ASCO Daily News Podcast, please rate, review, and subscribe wherever you get your podcasts. And again, thank you for joining us today. Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. Find out more about today's speakers: Dr. Sumanta (Monty) Pal @montypal Dr. Kimmie Ng @KimmieNgMD Follow ASCO on social media: @ASCO on Twitter ASCO on Bluesky ASCO on Facebook ASCO on LinkedIn Disclosures: Dr. Sumanta (Monty) Pal: Speakers' Bureau: MJH Life Sciences, IntrisiQ, Peerview Research Funding (Inst.): Exelixis, Merck, Osel, Genentech, Crispr Therapeutics, Adicet Bio, ArsenalBio, Xencor, Miyarsian Pharmaceutical Travel, Accommodations, Expenses: Crispr Therapeutics, Ipsen, Exelixis Dr. Kimmie Ng: Honoraria: Seagen, GlaxoSmithKline Consulting or Advisory Role: CytomX Therapeutics, Jazz Pharmaceuticals, Revolution Medicines, Abbvie, Bayer, Pfizer, Agenus, Johnson & Johnson/Janssen, Etiome, AstraZeneca Research Funding (Inst.): Pharmavite, Janssen Other Relationship: JAMA
Cheryl Reeves, Senior Editor at The Lancet Oncology, is joined by Dr Jinming Li, from the Department of Colorectal Surgery, Fudan University Shanghai Cancer Centre, Shanghai, China to discuss his international, multicohort, observational study on patterns in genomic mutations among patients with early-onset colorectal cancer.Read the full article:https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(25)00239-6?dgcid=buzzsprout_icw_podcast_July_25_lanoncTell us what you thought about this episodeContinue this conversation on social!Follow us today at...https://thelancet.bsky.social/https://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv
The incidence of early onset colorectal cancer (EOCRC) has been rising prompting the change in change in screening guidelines to 45 years of age for average risk patients. Join us for an in-depth discussion with guest speakers Dr. Andrea Cercek and Dr. Nancy You, where we provide a comprehensive look at the growing challenge of EOCRC. Hosts: - Dr. Janet Alvarez - General Surgery Resident at New York Medical College/Metropolitan Hospital Center - Dr. Wini Zambare – General Surgery Resident at Weill Cornell Medical Center/New York Presbyterian - Dr. Phil Bauer, Graduating Colorectal Surgical Oncology Fellow at Memorial Sloan Kettering Cancer Center - Dr. J. Joshua Smith MD, PhD, Chair, Department of Colon and Rectal Surgery at MD Anderson Cancer Center - Dr. Andrea Cercek - Gastrointestinal Medical Oncologist at Memorial Sloan Kettering Cancer Center - Dr. Y. Nancy You, MD MHSc - Professor, Department of Colon and Rectal Surgery at MD Anderson Cancer Center Learning objectives: - Describe trends in incidence of colorectal cancer, with emphasis on the rise of EOCRC. - Identify age groups and demographics most affected by EOCRC. - Summarize USPSTF recommendations for colorectal cancer screening. - Distinguish between screening methods (e.g., colonoscopy, FIT-DNA) and their sensitivity. - Understand treatment approaches for colon and rectal cancer (CRC) - Understand the role of mismatch repair (MMR) status in guiding treatment. - Outline the importance of genetic counseling and testing in young patients. - Discuss racial, ethnic, and socioeconomic disparities in CRC incidence and outcomes. - Describe the impact of cancer treatment on fertility and sexual health. - Review fertility preservation options. - Identify the value of integrated care teams for young CRC patients. References: 1. Siegel, R. L. et al. Colorectal Cancer Incidence Patterns in the United States, 1974–2013. JNCI J. Natl. Cancer Inst. 109, djw322 (2017). https://pubmed.ncbi.nlm.nih.gov/28376186/ 2. Abboud, Y. et al. Rising Incidence and Mortality of Early-Onset Colorectal Cancer in Young Cohorts Associated with Delayed Diagnosis. Cancers 17, 1500 (2025). https://pubmed.ncbi.nlm.nih.gov/40361427/ 3. Phang, R. et al. Is the Incidence of Early-Onset Adenocarcinomas in Aotearoa New Zealand Increasing? Asia Pac. J. Clin. Oncol.https://pubmed.ncbi.nlm.nih.gov/40384533/ 4. Vitaloni, M. et al. Clinical challenges and patient experiences in early-onset colorectal cancer: insights from seven European countries. BMC Gastroenterol. 25, 378 (2025). https://pubmed.ncbi.nlm.nih.gov/40375142/ 5. Siegel, R. L. et al. Global patterns and trends in colorectal cancer incidence in young adults. (2019) doi:10.1136/gutjnl-2019-319511. https://pubmed.ncbi.nlm.nih.gov/31488504/ 6. Cercek, A. et al. A Comprehensive Comparison of Early-Onset and Average-Onset Colorectal Cancers. J. Natl. Cancer Inst. 113, 1683–1692 (2021). https://pubmed.ncbi.nlm.nih.gov/34405229/ 7. Zheng, X. et al. Comprehensive Assessment of Diet Quality and Risk of Precursors of Early-Onset Colorectal Cancer. JNCI J. Natl. Cancer Inst. 113, 543–552 (2021). https://pubmed.ncbi.nlm.nih.gov/33136160/ 8. Standl, E. & Schnell, O. Increased Risk of Cancer—An Integral Component of the Cardio–Renal–Metabolic Disease Cluster and Its Management. Cells 14, 564 (2025). https://pubmed.ncbi.nlm.nih.gov/40277890/ 9. Muller, C., Ihionkhan, E., Stoffel, E. M. & Kupfer, S. S. Disparities in Early-Onset Colorectal Cancer. Cells 10, 1018 (2021). https://pubmed.ncbi.nlm.nih.gov/33925893/ 10. US Preventive Services Task Force. Screening for Colorectal Cancer: US Preventive Services Task Force Recommendation Statement. JAMA 325, 1965–1977 (2021). https://pubmed.ncbi.nlm.nih.gov/34003218/ 11. Fwelo, P. et al. Differential Colorectal Cancer Mortality Across Racial and Ethnic Groups: Impact of Socioeconomic Status, Clinicopathology, and Treatment-Related Factors. Cancer Med. 14, e70612 (2025). https://pubmed.ncbi.nlm.nih.gov/40040375/ 12. Lansdorp-Vogelaar, I. et al. Contribution of Screening and Survival Differences to Racial Disparities in Colorectal Cancer Rates. Cancer Epidemiol. Biomarkers Prev. 21, 728–736 (2012). https://pubmed.ncbi.nlm.nih.gov/22514249/ 13. Ko, T. M. et al. Low neighborhood socioeconomic status is associated with poor outcomes in young adults with colorectal cancer. Surgery 176, 626–632 (2024). https://pubmed.ncbi.nlm.nih.gov/38972769/ 14. Siegel, R. L., Wagle, N. S., Cercek, A., Smith, R. A. & Jemal, A. Colorectal cancer statistics, 2023. CA. Cancer J. Clin. 73, 233–254 (2023). https://pubmed.ncbi.nlm.nih.gov/36856579/ 15. Jain, S., Maque, J., Galoosian, A., Osuna-Garcia, A. & May, F. P. Optimal Strategies for Colorectal Cancer Screening. Curr. Treat. Options Oncol. 23, 474–493 (2022). https://pubmed.ncbi.nlm.nih.gov/35316477/ 16. Zauber, A. G. The Impact of Screening on Colorectal Cancer Mortality and Incidence: Has It Really Made a Difference? Dig. Dis. Sci. 60, 681–691 (2015). https://pubmed.ncbi.nlm.nih.gov/25740556/ 17. Edwards, B. K. et al. Annual report to the nation on the status of cancer, 1975-2006, featuring colorectal cancer trends and impact of interventions (risk factors, screening, and treatment) to reduce future rates. Cancer 116, 544–573 (2010). https://pubmed.ncbi.nlm.nih.gov/19998273/ 18. Cercek, A. et al. Nonoperative Management of Mismatch Repair–Deficient Tumors. New England Journal of Medicine 392, 2297–2308 (2025). https://pubmed.ncbi.nlm.nih.gov/40293177/ 19. Monge, C., Waldrup, B., Carranza, F. G. & Velazquez-Villarreal, E. Molecular Heterogeneity in Early-Onset Colorectal Cancer: Pathway-Specific Insights in High-Risk Populations. Cancers 17, 1325 (2025). https://pubmed.ncbi.nlm.nih.gov/40282501/ 20. Monge, C., Waldrup, B., Carranza, F. G. & Velazquez-Villarreal, E. Ethnicity-Specific Molecular Alterations in MAPK and JAK/STAT Pathways in Early-Onset Colorectal Cancer. Cancers 17, 1093 (2025). https://pubmed.ncbi.nlm.nih.gov/40227607/ 21. Benson, A. B. et al. Colon Cancer, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology. J. Natl. Compr. Cancer Netw. JNCCN 19, 329–359 (2021). https://pubmed.ncbi.nlm.nih.gov/33724754/ 22. Christenson, E. S. et al. Nivolumab and Relatlimab for the treatment of patients with unresectable or metastatic mismatch repair proficient colorectal cancer. https://pubmed.ncbi.nlm.nih.gov/40388545/ 23. Dasari, A. et al. Fruquintinib versus placebo in patients with refractory metastatic colorectal cancer (FRESCO-2): an international, multicentre, randomised, double-blind, phase 3 study. The Lancet 402, 41–53 (2023). https://pubmed.ncbi.nlm.nih.gov/37331369/ 24. Strickler, J. H. et al. Tucatinib plus trastuzumab for chemotherapy-refractory, HER2-positive, RAS wild-type unresectable or metastatic colorectal cancer (MOUNTAINEER): a multicentre, open-label, phase 2 study. Lancet Oncol. 24, 496–508 (2023). https://pubmed.ncbi.nlm.nih.gov/37142372/ 25. Sauer, R. et al. Preoperative versus Postoperative Chemoradiotherapy for Rectal Cancer. N. Engl. J. Med. 351, 1731–1740 (2004). https://pubmed.ncbi.nlm.nih.gov/15496622/ 26. Cercek, A. et al. Adoption of Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer. JAMA Oncol. 4, e180071 (2018). https://pubmed.ncbi.nlm.nih.gov/29566109/ 27. Garcia-Aguilar, J. et al. Organ Preservation in Patients With Rectal Adenocarcinoma Treated With Total Neoadjuvant Therapy. J. Clin. Oncol. 40, 2546–2556 (2022). https://pubmed.ncbi.nlm.nih.gov/35483010/ 28. Schrag, D. et al. Preoperative Treatment of Locally Advanced Rectal Cancer. N. Engl. J. Med. 389, 322–334 (2023). https://pubmed.ncbi.nlm.nih.gov/37272534/ 29. Kunkler, I. H., Williams, L. J., Jack, W. J. L., Cameron, D. A. & Dixon, J. M. Breast-Conserving Surgery with or without Irradiation in Early Breast Cancer. N. Engl. J. Med. 388, 585–594 (2023). https://pubmed.ncbi.nlm.nih.gov/36791159/ 30. Jacobsen, R. L., Macpherson, C. F., Pflugeisen, B. M. & Johnson, R. H. Care Experience, by Site of Care, for Adolescents and Young Adults With Cancer. JCO Oncol. Pract. (2021) doi:10.1200/OP.20.00840. https://pubmed.ncbi.nlm.nih.gov/33566700/ 31. Ruddy, K. J. et al. Prospective Study of Fertility Concerns and Preservation Strategies in Young Women With Breast Cancer. J. Clin. Oncol. (2014) doi:10.1200/JCO.2013.52.8877. https://pubmed.ncbi.nlm.nih.gov/24567428/ 32. Su, H. I. et al. Fertility Preservation in People With Cancer: ASCO Guideline Update. J. Clin. Oncol. 43, 1488–1515 (2025). https://pubmed.ncbi.nlm.nih.gov/40106739/ 33. Smith, K. L., Gracia, C., Sokalska, A. & Moore, H. Advances in Fertility Preservation for Young Women With Cancer. Am. Soc. Clin. Oncol. Educ. Book 27–37 (2018) doi:10.1200/EDBK_208301. https://pubmed.ncbi.nlm.nih.gov/30231357/ 34. Blumenfeld, Z. How to Preserve Fertility in Young Women Exposed to Chemotherapy? The Role of GnRH Agonist Cotreatment in Addition to Cryopreservation of Embrya, Oocytes, or Ovaries. The Oncologist 12, 1044–1054 (2007). 35. Bhagavath, B. The current and future state of surgery in reproductive endocrinology. Curr. Opin. Obstet. Gynecol. 34, 164 (2022). 36. Ribeiro, R. et al. Uterine transposition: technique and a case report. Fertil. Steril. 108, 320-324.e1 (2017). 37. Yazdani, A., Sweterlitsch, K. M., Kim, H., Flyckt, R. L. & Christianson, M. S. Surgical Innovations to Protect Fertility from Oncologic Pelvic Radiation Therapy: Ovarian Transposition and Uterine Fixation. J. Clin. Med. 13, 5577 (2024). 38. Holowatyj, A. N., Eng, C. & Lewis, M. A. Incorporating Reproductive Health in the Clinical Management of Early-Onset Colorectal Cancer. JCO Oncol. Pract. 18, 169–172 (2022). ***Behind the Knife Colorectal Surgery Oral Board Audio Review: https://app.behindtheknife.org/course-details/colorectal-surgery-oral-board-audio-review Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more. If you liked this episode, check out our recent episodes here: https://app.behindtheknife.org/listen
Host: Mindy McCulley, MS Family and Consumer Sciences Extension Specialist for Instructional Support, University of Kentucky Guest: Dr. Erin Wolf-Horrell, MD Assistant Professor, Colorectal Surgery, UK Markey Cancer Center Cancer Conversations Episode 65 Join us on Cancer Conversations as Dr. Erin Wolf-Horrell, Assistant Professor of Colorectal Surgery at the University of Kentucky Markey Cancer Center shares about the pressing issues of early-onset colorectal cancer affecting younger patients in Kentucky. Dr. Wolf-Horrell discusses the trends and potential environmental factors contributing to the rise of colorectal cancer in individuals under 50. Gain understanding on how these cancers differ from those in older adults and learn about the unique symptoms, diagnostic challenges, and the importance of timely screening. Explore why awareness and self-advocacy are crucial for early detection, especially given Kentucky's high incidence and mortality rates for colorectal cancer. This episode equips listeners with knowledge to better advocate for their health and highlights the need for increased vigilance and screening in younger populations. Connect with the UK Markey Center Online Markey Cancer Center On Facebook @UKMarkey On X @UKMarkey
Editor's Summary by Linda Brubaker, MD, and Preeti Malani, MD, MSJ, Deputy Editors of JAMA, the Journal of the American Medical Association, for articles published from July 12-18, 2025.
Early-onset gastrointestinal cancers, typically defined as occurring in patients younger than age 50, are increasing worldwide. A recent JAMA Review summarizes current data on early-onset colorectal, pancreatic, and esophagogastric cancers. Coauthor Kimmie Ng, MD, MPH, of Dana-Farber Cancer Institute joins JAMA Deputy Editor Kristin Walter, MD, MS to discuss. Related Content: Early-Onset Gastrointestinal Cancers Screening for Helicobacter pylori to Prevent Gastric Cancer First-Line Sugemalimab Plus Chemotherapy for Advanced Gastric Cancer
Our children and teens are increasingly being targeted by online predators wanting to exploit, abuse and sextort them. With June being Internet Safety Month, Manny Munoz discussed these things with former Florida State Senator Lauren Book a child-abuse survivor, advocate, and founder of the nonprofit Lauren's Kids to educate families. Kids these days are entering puberty earlier than they ever have. Why is it happening, what problems does it contribute to and what do parents need to know? Munoz spoke with Renowned Clinical Psychologist Dr. Sheryl Ziegler on the Early Onset of Puberty, What Parents Can Do to Help and Her New Book THE CRUCIAL YEARS
Australia’s leading dietitians, Susie Burrell and Leanne Ward, delve into a pressing health concern: the increasing incidence of aggressive cancers, such as bowel and breast cancer, among young adults. They explore recent research findings, discuss potential lifestyle contributors, and emphasize the importance of early detection and routine health screenings. Also Featured: A novel approach to structuring weekly meal plans from a new diet study. A review of a popular new winter porridge. Listener Q&A: The role of fiber powders in maintaining gut health. Why Listen? This episode sheds light on a concerning health trend affecting younger populations and offers actionable insights into prevention and early detection. Whether you’re in your 20s or 30s, or have loved ones who are, this discussion is crucial for informed health decisions.See omnystudio.com/listener for privacy information.
We kicked off the program with four news stories and different guests on the stories we think you need to know about!The Early Onset of Puberty, What Parents Can Do to Help with guest Dr. Sheryl Gonzalez Ziegler – PsychologistU.S. News Ranks the Best States for 2025 – Utah is #1 but NH is #2! MA is #9 with guest Jaclyn Jeffrey-Wilensky - U.S. News Senior Data EditorWhat you need to know about Sean 'Diddy' Combs' federal trial with guest Jeremy Rosenthal – Defense Attorney5 foods that can damage your brain and increase your dementia risk — and what to swap them for with guest Dr. Patrick Porter, PhD - Expert in Brain Health & Founder of BrainTapListen to WBZ NewsRadio on the NEW iHeart Radio app and be sure to set WBZ NewsRadio as your #1 preset!
The alarming rise of early-onset cancers, particularly in individuals under 50, demands a critical shift in our understanding and approach to cancer care. In this episode, Dr. Karin Tollefson, Chief Oncology Medical Officer at Pfizer, discusses the concerning 79% increase in cancer diagnoses among younger people since 1990, highlighting the urgent need to address this trend. She emphasizes that this is a multifactorial issue, with likely contributors including Western lifestyle factors such as poor diet, obesity, sedentary habits, and exposure to toxins, as well as genetic predispositions. Dr. Tollefson also underscores the need for increased screening accessibility, particularly with colonoscopies, and molecular testing to tailor treatments for younger patients often diagnosed at later stages. Furthermore, she addresses the importance of making clinical trials more accessible to diverse populations and ensuring comprehensive survivorship care, including mental health, family planning, and fertility considerations, as cancer survival rates increase. Finally, Dr. Tollefson calls on the need to partner with advocacy organizations and to educate the public about early detection, healthy lifestyles, and available resources. Tune in and learn about the critical shifts needed in cancer care to address early-onset cases. Resources: Follow Dr. Karin Tollefson, Chief Oncology Medical Officer at Pfizer, on LinkedIn. Discover more about Pfizer on their LinkedIn and website. Read more on Pfizer in Oncology here. Patient Resources/Advocacy Links: Explore This Is Living With Cancer's Advocacy Support's website. Visit the Global Colorectal Cancer Alliance's website here. (Pfizer was one of their sponsors) Learn more about the transformative work CancerCare is doing. Find CancerCare's guide on Biomarker Testing here. Read the best practices for Biomarker Testing Coverage here. (Pfizer had input and was a sponsor) Get AONN Biomarker Navigation here. For the Precision Medicine Toolkit, look here. Empower yourself or your patients with essential navigation resources–a site co-created with AONN, to find materials on breast, prostate, health equity, geriatric, and more. (Patient navigators can download and share educational tools for enhanced support.) Deepen your understanding of prostate cancer here.
In this powerful episode, we share a deeply personal story about the devastating impact of early-onset colorectal cancer—and the urgent need for better screening. Our guest, Dr. George Beauregard, is an internal medicine physician and healthcare executive whose world changed forever in 2017 when his newly married 29-year-old son was diagnosed with stage 4 colorectal cancer—just a month after his wedding. Through his son's courageous fight and advocacy, Dr. Beauregard found a renewed purpose: raising awareness about the alarming rise in early-onset cases and the need for improved screening and research. He also shares insights from his memoir, Reservations For Nine: A Doctor's Family Confronts Cancer, blending his personal and professional perspectives. Join us as we discuss his son's lasting legacy, the emotional and medical lessons from their journey, and the fight for earlier detection. This conversation is a call to action for greater awareness, earlier intervention, and meaningful change.
In this episode of Medical Matters Podcast, Dr. Peter Brier and Nurse Practitioner Kelly McCormick discuss the increase in Early Onset Cancer. Studies show on average there has been a one to two-percent increase in cancers diagnosed in adults aged 18 to 49. The doctors cite the changing manifestation of tumors, but also possible reasons, including lifestyle and environment. Reasons are examined in this article from UChicagoMedicine -- further, this recent examination of the issue by Yale Medicine offers evidence that cancers in younger people show some differences. Here, the American Cancer Society offers the ages for routine screening for several cancers.
Story at-a-glance Rising incidence of early-onset colorectal cancer is linked to changes in the gut microbiome, with specific bacterial strains producing mutagenic chemicals that contribute to cancer risk Global studies are underway to identify mutational signatures associated with gut bacteria, highlighting the significant role of dysbiosis in colorectal carcinogenesis Understanding the influence of gut bacteria on cancer development could lead to innovative therapeutic strategies, offering new avenues for prevention and treatment Research has identified a subtype of E. coli producing colibactin, a mutagen associated with cancer, suggesting that early exposure increases the risk of developing cancer at a younger age Dysbiosis, characterized by an imbalance in gut microbiota, is linked to colorectal cancer through mechanisms like genotoxicity, inflammation and oxidative stress, with specific bacteria such as Streptococcus bovis and Fusobacterium spp. playing a central role
While cancer deaths are falling nationally, new cases are increasing among younger adults at alarming rates, particularly for breast and gastrointestinal cancers.
About Dr. Karin Tollefson:Dr. Karin Tollefson is a highly accomplished pharmaceutical executive with over 30 years of experience dedicated to advancing cancer care. Currently serving as Chief Oncology Medical Officer at Pfizer, she leads the Oncology Global and US Medical Affairs Division. Before joining Pfizer in 2023, Dr. Tollefson held the role of Senior Vice President and Head of Global Medical Affairs at Seagen Inc., where she successfully launched three practice-changing medicines and built a global medical affairs organization. Her extensive career includes significant tenure at Eli Lilly and Company, where she held various leadership roles in clinical operations, development, and medical affairs. Throughout her career, she has contributed to the launch of eight new medicines, impacting patient care across multiple tumor types and therapeutic areas. Dr. Tollefson is an Independent Director on the Board for Verastem Oncology, and has also served on the boards of the American Lung Association and the Leukemia and Lymphoma Society. She is a 2024 Healthcare Businesswomen's Association Luminary Award recipient, and is a strong advocate for women in the oncology field, being a sponsor of both the Oncology Women's Network and the Pfizer Butterfly Community at Pfizer. She holds a Doctorate of Pharmacy from the University of Kansas and completed her undergraduate studies at Kansas State University.Things You'll Learn:The incidence of cancer in people under 50 has increased by 79% since 1990, marking a significant and alarming trend that needs immediate attention, especially with colorectal cancer now the leading cause of cancer death in men and second in women younger than 50 years. Western lifestyle factors such as poor diet, obesity, sedentary behavior, and exposure to toxins are likely significant contributors to the rise of early-onset cancers, suggesting that shifts in lifestyle and public health initiatives could impact cancer rates.Younger cancer patients are often diagnosed at later stages due to a lack of preventative care and symptoms being easily dismissed.Increased screening accessibility is crucial for early detection and prevention. This includes molecular testing and colonoscopies, which offer the opportunity to remove precancerous polyps, preventing them from developing into something more serious.The battle against cancer requires collaborative efforts between healthcare providers, academic institutions, industry partners, and advocacy organizations. This is not just one organization's fight; collaborative efforts must continue.Resources:Follow Dr. Karin Tollefson, Chief Oncology Medical Officer at Pfizer, on LinkedIn.Discover more about Pfizer on their LinkedIn and website.Read more on Pfizer in Oncology here. Patient Resources/Advocacy Links:Explore This Is Living With Cancer's Advocacy Support's website.Visit the Global Colorectal Cancer Alliance's website here. (Pfizer was one of their sponsors)Learn more about the transformative work CancerCare is doing.Find CancerCare's guide on Biomarker Testing here.Read the best practices for Biomarker Testing Coverage here. (Pfizer had input and was a sponsor)Get AONN Biomarker Navigation here. For the Precision Medicine Toolkit, look here.Empower yourself or your patients with essential navigation resources–a site co-created with AONN, to find materials on breast, prostate, health equity, geriatric, and more. (Patient navigators can download and share educational tools for enhanced support.)Deepen your understanding of prostate cancer here.
Send us a textEffects of pregnancy-induced hypertension on early-onset neonatal thrombocytopenia. Ye M, Zhou C, Li L, Wang L, Zhang M.BMC Pregnancy Childbirth. 2025 Jan 24;25(1):67. doi: 10.1186/s12884-025-07193-z.PMID: 39856602 Free PMC article.As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Global Burden of Early-Onset Ischemic Heart Disease, 1990 to 2019.
Dan Le Batard has nice eyelids, and Dianna Russini and her biceps wants to make sure he knows it. Dianna is here to break down all things football, but she has to help us get down to Dan's best celebrity look-alike first. Then, Dianna explains the dilemma she's facing with the Eagles game this weekend as her kids don't have a babysitter, her season ticket holding husband wants to attend as a fan, and she has to work. Plus, the latest on Tom Brady and the Raiders, Mike McCarthy, the Chicago Bears. the Tennessee Titans, Marcus Freeman, Russell Wilson, and SO. MUCH. MORE. Also, Jeremy and Dan break the Miami Heat's trust and announce the return of the original Vice jerseys...10 seconds before they were supposed to. Learn more about your ad choices. Visit podcastchoices.com/adchoices
Credits: 0.25 AMA PRA Category 1 Credit™ CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-411 Overview: This episode focuses on the rising prevalence of early-onset colorectal cancer and its critical indicators. Learn to recognize key symptoms, ensure timely diagnostic workups, and effectively address red flags to prevent delayed diagnosis. Episode resource links: Demb, J., Kolb, J. M., Dounel, J., Fritz, C. D. L., Advani, S. M., Cao, Y., Coppernoll-Blach, P., Dwyer, A. J., Perea, J., Heskett, K. M., Holowatyj, A. N., Lieu, C. H., Singh, S., Spaander, M. C. W., Vuik, F. E. R., & Gupta, S. (2024). Red Flag Signs and Symptoms for Patients With Early-Onset Colorectal Cancer: A Systematic Review and Meta-Analysis. JAMA network open, 7(5), e2413157. https://doi.org/10.1001/jamanetworkopen.2024.13157 US Preventive Services Task Force Screening Guidelines for Colorectal Cancer: https://www.uspreventiveservicestaskforce.org/uspstf/recommendation/colorectal-cancer-screening American Cancer Society Infographic for Patients: Colorectal Cancer: Catching it Early https://www.cancer.org/cancer/types/colon-rectal-cancer/prevention-infographic.html Gómez-Molina R, Suárez M, Martínez R, Chilet M, Bauça JM, Mateo J. Utility of Stool-Based Tests for Colorectal Cancer Detection: A Comprehensive Review. Healthcare. 2024; 12(16):1645. https://doi.org/10.3390/healthcare12161645 Guest: Jill M. Terrien PhD, ANP-BC Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com
Credits: 0.25 AMA PRA Category 1 Credit™ CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-411 Overview: This episode focuses on the rising prevalence of early-onset colorectal cancer and its critical indicators. Learn to recognize key symptoms, ensure timely diagnostic workups, and effectively address red flags to prevent delayed diagnosis. Episode resource links: Demb, J., Kolb, J. M., Dounel, J., Fritz, C. D. L., Advani, S. M., Cao, Y., Coppernoll-Blach, P., Dwyer, A. J., Perea, J., Heskett, K. M., Holowatyj, A. N., Lieu, C. H., Singh, S., Spaander, M. C. W., Vuik, F. E. R., & Gupta, S. (2024). Red Flag Signs and Symptoms for Patients With Early-Onset Colorectal Cancer: A Systematic Review and Meta-Analysis. JAMA network open, 7(5), e2413157. https://doi.org/10.1001/jamanetworkopen.2024.13157 US Preventive Services Task Force Screening Guidelines for Colorectal Cancer: https://www.uspreventiveservicestaskforce.org/uspstf/recommendation/colorectal-cancer-screening American Cancer Society Infographic for Patients: Colorectal Cancer: Catching it Early https://www.cancer.org/cancer/types/colon-rectal-cancer/prevention-infographic.html Gómez-Molina R, Suárez M, Martínez R, Chilet M, Bauça JM, Mateo J. Utility of Stool-Based Tests for Colorectal Cancer Detection: A Comprehensive Review. Healthcare. 2024; 12(16):1645. https://doi.org/10.3390/healthcare12161645 Guest: Jill M. Terrien PhD, ANP-BC Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com
Sara and Heather are exploring the nature of codependency and its impact on individuals pursuing an alcohol-free lifestyle. Through Heather's personal experiences and in-depth research, they discuss key aspects such as caretaking as control, the chameleon effect, chronic guilt, and the rescue complex. They highlight the roots of codependency in dysfunctional families and its manifestation in adult relationships and parenting. Practical advice is offered on recognizing and overcoming these behaviors through strategies like setting boundaries, embracing authenticity, practicing mindfulness, and seeking professional help. Additionally, the role of community support, creativity, and journaling is emphasized, along with the benefits of groups like Codependents Anonymous. The episode encourages listeners to reclaim their personal identity, enhance emotional well-being, and invites them to engage with supportive communities for continued growth. 00:00 Introduction to Codependency 00:51 Heather's Personal Journey with Codependency 02:33 Characteristics of Codependency 03:22 The Chameleon Effect and Personal Reflections 04:51 Chronic Guilt and Emotional Invisibility 08:25 Rescue Complex and Its Implications 12:42 Causes and Early Onset of Codependency 15:09 Understanding Codependency Beyond Alcohol 15:45 The Real Work Begins After Quitting Alcohol 17:55 Strategies to Break Free from Codependency 17:57 Embracing Authenticity and Self-Discovery 19:37 The Importance of Setting Boundaries 20:11 Reframing Self-Care as a Necessity 23:21 The Power of Community Support 26:04 Conclusion: Reclaiming Your Identity Resources Mentioned: Join The Daymakers Community for personalized support and real-time interaction on alcohol-free topics. One-on-one coaching spots available with Heather. If you enjoy this episode, share it with a friend who's navigating change or looking to stay alcohol-free. And please support the podcast by leaving a review. Stay connected and tune in every Tuesday for more inspiring conversations on living alcohol-free! ************************************************ Looking for support on your alcohol free journey? Consider joining us in the Day Makers Community. CLICK HERE for all the details. Want some 1-on-1 support on your alcohol free journey? Work with Heather as your alcohol free coach. CLICK HERE to start working with Heather today. ************************************************ Follow the podcast on Social Media: IG: @nomorewasteddays.pod Follow Sara on Social Media: IG: @no_more_wasted_days TikTok: @no_more_wasted_days Facebook: https://www.facebook.com/NoMoreWastedDaysOfficial Follow Heather on Social Media: IG: @theheatherleecollective TikTok: @thealcoholfreecoach
In this episode, we meet Bobby Krause, a former college athlete and sales executive who was diagnosed with early-onset Parkinson's disease at age 42. Bobby candidly discusses his struggle with debilitating tremors that impacted his ability to engage with his family and perform at work. After experiencing severe side effects from medications, Bobby turned to focused ultrasound treatment for help. Bobby provides a vivid account of the focused ultrasound procedure, describing the immediate and profound results he experienced. Within hours, his tremors disappeared and muscle rigidity eased, allowing him to hike with his sons the very same day. Bobby remains tremor-free and has returned to coaching basketball and other activities he previously enjoyed. Now a passionate advocate for focused ultrasound technology, Bobby has spoken to U.S. policymakers about his experience and founded the Be Still Foundation. The foundation aims to provide financial assistance for those seeking focused ultrasound treatment and raise awareness about this innovative technology. Be Still Foundation SHOW TRANSCRIPT ---------------------------- QUESTIONS? Email podcast@fusfoundation.org if you have a question or comment about the show, or if you would you like to connect about future guest appearances. Email info@fusfoundation.org if you have questions about focused ultrasound or the Foundation. FUSF SOCIAL MEDIA LinkedIn X Facebook Instagram TikTok YouTube FUSF WEBSITE https://www.fusfoundation.org SIGN UP FOR OUR FREE NEWSLETTER https://www.fusfoundation.org/newsletter-signup/ READ THE LATEST NEWSLETTER https://www.fusfoundation.org/the-foundation/news-media/newsletter/ DOWNLOAD "THE TUMOR" BY JOHN GRISHAM (FREE E-BOOK) https://www.fusfoundation.org/read-the-tumor-by-john-grisham/
This episode of the Game Plan Podcast is sponsored by BetterHelp.If you're thinking of starting therapy, give BetterHelp a try. It's entirely online. Designed to be convenient, flexible, and suited to your schedule. Just fill out a brief questionnaire to get matched with a licensed therapist, and switch therapists any time for no additional charge.Visit https://www.betterhelp.com/Gameplan today to get 10% off your first month.Welcome back to another episode of the Game Plan Podcast!Today, we're sitting down with Louisa Nicola, neuroscientist and human performance expert, to unlock the secrets of optimizing your brain and body. Louisa has worked with top athletes and executives, helping them achieve peak performance through science-backed strategies.In this episode, Louisa dives into the essentials of human performance, breaking down the importance of exercise, sleep, and nutrition. We explore the benefits of cold exposure, ice baths, and saunas—why these techniques are more than just trends and how they can supercharge your brain and body.We also dig into the role of creatine for cognitive health, debunk myths around biohacking, and reveal the key to mastering your sleep for better mental clarity and productivity. Stay tuned till the end as Louisa offers insights into managing toxins like microplastics, the power of morning sunlight, and how a simple shift in your daily routine can drastically improve your life.Hit play now, and don't forget to like, comment, and subscribe for more high-performance insights!Louisa's Socials:Instagram: https://www.instagram.com/louisanicola_/YouTube: https://www.youtube.com/c/LouisaNicolaCheck out the best protein pancakes in the world at Fuel Cakes: https://fuelcakes.com/
In this episode of the Brain and Body Things podcast, host Dr. Natasha Mehta is joined by Dr. Veda Giri and Dr. Nancy Borstelmann from Yale Cancer Center to discuss early onset cancer. Dr. Giri, a medical oncologist specializing in clinical cancer genetics, and Dr. Borstelmann, an expert in chronic disease epidemiology and social work, both co-lead Yale's Early Onset Cancer Program. They delve into the unique needs and challenges faced by young cancer patients, insights into genetic testing, the importance of tailored cancer screening, and the multifactorial nature of rising cancer rates in younger populations. The episode also highlights novel approaches in patient care, support systems, and the roles of lifestyle and mental health in managing cancer.00:00 Introduction to the Brain and Body Things Podcast00:41 Season Four Kickoff: Early Onset Cancer01:18 Meet the Experts: Dr. Giri and Dr. Borstmann02:51 Understanding Early Onset Cancer09:07 Genetic Testing and Cancer Screening18:27 Rising Rates of Early Onset Cancer22:16 Holistic Care for Cancer Patients29:18 Yale's Early Onset Cancer Program33:26 Patient Engagement and Awareness34:14 Personalized Patient Navigation35:48 Addressing Clinical Trials and Support Needs37:29 Psychosocial Focus in Healthcare38:50 Cancer Screening and Risk Assessment41:15 Healthy Lifestyle and Mental Health47:49 Rising Cancer Rates and Prevention49:13 Self-Care Practices of Healthcare Professionals58:18 Conclusion and Final ThoughtsThe podcast episodes drop weekly on Monday's in seasonal chunks. Subscribe to stay up to date, and tune in when you can! Be sure to rate, review, and follow on your favorite podcast app and let me know what other brain & body things you'd like to hear about. For more information about me, check out my website.Follow me on Instagram or Tik Tok @drnatashamehta.This episode is not sponsored.
Send us a Text Message.Trends in C-Reactive Protein Use in Early-Onset Sepsis Evaluations and Associated Antibiotic Use.Barboza AZ, Flannery DD, Shu D, Galloway M, Dhudasia MB, Bonafide CP, Benitz WE, Gerber JS, Mukhopadhyay S.J Pediatr. 2024 Jun 18:114153. doi: 10.1016/j.jpeds.2024.114153. Online ahead of print.PMID: 38901777As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!
In a recent American Cancer Society publication, there are increasing data that rates of colorectal cancer are rising rapidly among people in their 20s, 30s and 40s. This has certainly caught the attention of the lay press, most recently in a widely circulated New York Times article published in March 2024. Today, we welcome Dr. Chris Cann, who is an Assistant Professor of Hematology/Oncology at the Fox Chase Cancer Center in Philadelphia where he focuses on GI oncology and has a particular area of interest in early onset colorectal cancer. In his short career thus far, Dr. Cann is already making a name for himself in this space on a national level and so we are so glad he was able to join us for this special discussion. Dr. Cann sheds light on what we know and what we don't know about this phenomenon. Definitely an episode to check out!** Want to review the show notes for this episode and others? Check out our website: https://www.thefellowoncall.com/our-episodesLove what you hear? Tell a friend and leave a review on our podcast streaming platforms!Twitter: @TheFellowOnCallInstagram: @TheFellowOnCallListen in on: Apple Podcast, Spotify, and Google Podcast
This is the first half of our conversation. The full episode and the complete archive of Subversive episodes, including exclusive episodes and my writing, are available on Substack. You can also subscribe to the podcast sans writing on Patreon for a bit less. This is how the show is financed and grows, so I appreciate every contribution! Please subscribe at: https://www.alexkaschuta.com/ https://www.patreon.com/aksubversive Our conversation explores the genealogy and evolution of the alt-right movement, discussing its origins, key figures, and the reasons behind its rise and subsequent implosion. We also talk about the demographic makeup of the alt-right, the influence of events like the Ron Paul movement and the Trayvon Martin case, and the role of race and IQ in shaping the movement's ideology. The conversation also touches on the leadership vacuum within the alt-right and the challenges of navigating the online space, different styles of communication between men and women, the challenges women face in leadership roles, the changing dynamics of sexuality, and the impact of technology on society and much more. Walt Bismarck is a writer with a rapidly growing Substack presence and you can find him on Twitter as well. Chapters for the full chat 00:00 Introduction to the alt-right movement 06:04 Demographics and influences of the alt-right 13:09 The leadership vacuum and challenges of the online space 25:01 The emergence of the dissident right 34:47 Introduction and the Importance of Women in Leadership 38:02 The Changing Dynamics of Sexuality and Early Onset of Puberty 47:31 Navigating the Complexities of the Modern World 01:00:38 The Fragmentation of Political Movements 01:01:27 Engaging with Different Worldviews 01:02:35 Finding Fulfillment and Meaning in a Complex World 01:03:29 Ethical Implications of Emerging Technologies 01:10:05 The Historical and Cultural Dynamics of Eastern Europe The Walt Right We also mentioned a previous guest's Substack on the show, Regan Arntz-Gray. https://www.allcatsarefemale.com/ --- Send in a voice message: https://podcasters.spotify.com/pod/show/aksubversive/message
What hobby or personality trait do you have that makes you feel like an old person? A 2nd Date Update in a Cat Cafe, and Jon and Jake hold a Confession Wednesday!Jon & Chantel's Radio Podcast is your daily dose of fun and entertainment. Your podcast shouldn't give you anxiety! Let Jon and Chantel make you laugh, share their life stories, and give you the trending topics of the day.
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