Podcasts about localized

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Today's episode we will cover 2025 updates for localized renal cell carcinoma (RCC) with Dr. Tom Powles and Dr. Brian Rini from the urologic oncology podcast Uromigos! We will discuss risk factors, the presentation, staging, and treatment options. 

Will AI diminish the value of localized content? Sebastien Edgar of SEOSeb & Previsible examines why localization remains crucial despite AI advancements. He explains how properly localized content demonstrates market understanding, creates uniqueness, and can increase purchase likelihood by up to 40%. Edgar also highlights the significant opportunity gap between English-dominated web content and the small percentage of native English speakers worldwide.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this episode of the Ecommerce Coffee Break Podcast, we explore how AI is revolutionizing the way e-commerce brands expand into new markets. Join us as we chat with Bryan Murphy, CEO of Smartling, about the transformative power of AI in translation and localization. Discover how brands can now create a seamless, localized shopping experience for customers worldwide, breaking down barriers and boosting conversion rates. Tune in to learn about the latest AI advancements and how they can give your business a competitive edge in the global market. Topics discussed in this episode:  Why localizing content creates better customer experiences. How Smartling automates translation with AI. What 87% of consumers expect in online shopping. Why continuous localization matters for Shopify stores. How AI cuts translation time and costs. What Smartling does to grow global reach. Why language impacts buying decisions. How ASOS boosted conversions with Smartling. What's next for AI in e-commerce localization. Why e-commerce brands should adopt AI localization. Links & Resources Website: https://www.smartling.com/Shopify App: https://www.smartling.com/integrations/shopifyLinkedIn: https://www.linkedin.com/in/bryanmurphy2/Get access to more free resources by visiting the show notes athttps://tinyurl.com/2praxfn6MORE RESOURCES Subscribe to our FREE Newsletter: https://newsletter.ecommercecoffeebreak.com/ Free Store Optimization Beginners Guide: Instant PDF Download!

This panel discusses the "Localized History Project," which addresses the lack of Asian American, Native Hawaiian, and Pacific Islander (AANHPI) history in New York State's Eurocentric, test-driven curriculum. The Project advocates for both a "content and pedagogical revolution" to shift who is perceived as a historian and knowledge creator. The Project is youth-driven, centering young people through Youth Action Boards in various regions of New York, who develop resources for an archive and classroom use. Utilizing oral history, semi-structured interviews, and surveys, the project explores how the absence of AANHPI history impacts youth and aims to create a "living history" that challenges traditional, colonial frameworks of history education. The ultimate goal is to provide a community archive of localized histories to fill educational gaps and inspire revolutionary change.Panel was part of the Association for Asian American Studies 2025 Annual Conference

Dr. Chuck Link is the Executive Chairman of Syncromune, a company developing a novel immunotherapy approach for solid tumors by delivering the therapy into the tumor and surrounding lymph nodes to stimulate a systemic immune response. Their complex drug has four different components with varying levels of activity that activate the immune system and counteract immune suppression. This in situ immunotherapy technology, SYNC-T, was tested in a phase 1 trial for metastatic castration-resistant prostate cancer, which showed high response rates and a favorable safety profile with low rates of serious side effects and minimal autoimmune toxicity.   Chuck explains, "So, SYNC-T is a technology in which you put a needle directly into a tumor that can be done by a urologist in the prostate cancer situation, or by an interventional radiologist. That needle then the tip of it freezes, and does a freeze fracture. Think of a Coke bottle rupturing like in the freezer. And what that does is release the antigens from that patient's own specific tumor. So, it's personalized because the tumor proteins and antigens are used to create a vaccine effect that's released directly from the cancer." "The tumor microenvironment is basically within the tumor itself, and there are immune suppressive mechanisms that the tumor has evolved to protect it from the immune system. I like to think of it as a castle, multiple levels of defense where you have the castle itself, and then you have a castle wall, and then you have a moat, and then an army in front of the wall. So the cancer has multiple immune-suppressive mechanisms that are activated to defeat the immune system, even though cancer has a lot of abnormal, mutated proteins that the immune system should attack and destroy. So what SYNC-T accomplishes is it basically hits solutions for all four of those types of defense simultaneously to make it more difficult for the castle, in this case, the tumor, to protect itself." #Syncromune #Immunotherapy #MetastaticSolidTumors #Cancer #ProstateCancer syncromune.com Download the transcript here

Dr. Chuck Link is the Executive Chairman of Syncromune, a company developing a novel immunotherapy approach for solid tumors by delivering the therapy into the tumor and surrounding lymph nodes to stimulate a systemic immune response. Their complex drug has four different components with varying levels of activity that activate the immune system and counteract immune suppression. This in situ immunotherapy technology, SYNC-T, was tested in a phase 1 trial for metastatic castration-resistant prostate cancer, which showed high response rates and a favorable safety profile with low rates of serious side effects and minimal autoimmune toxicity.   Chuck explains, "So, SYNC-T is a technology in which you put a needle directly into a tumor that can be done by a urologist in the prostate cancer situation, or by an interventional radiologist. That needle then the tip of it freezes, and does a freeze fracture. Think of a Coke bottle rupturing like in the freezer. And what that does is release the antigens from that patient's own specific tumor. So, it's personalized because the tumor proteins and antigens are used to create a vaccine effect that's released directly from the cancer." "The tumor microenvironment is basically within the tumor itself, and there are immune suppressive mechanisms that the tumor has evolved to protect it from the immune system. I like to think of it as a castle, multiple levels of defense where you have the castle itself, and then you have a castle wall, and then you have a moat, and then an army in front of the wall. So the cancer has multiple immune-suppressive mechanisms that are activated to defeat the immune system, even though cancer has a lot of abnormal, mutated proteins that the immune system should attack and destroy. So what SYNC-T accomplishes is it basically hits solutions for all four of those types of defense simultaneously to make it more difficult for the castle, in this case, the tumor, to protect itself." #Syncromune #Immunotherapy #MetastaticSolidTumors #Cancer #ProstateCancer syncromune.com Listen to the podcast here

Episode 69: The Hidden Harms of Vaping and Nicotine Pouches - What Dental Professionals Need to Know Hosts: Tabitha Acret (Australia) & Melissa Obrotka (USA)  Episode Description  In this critical episode, Tabitha and Melissa tackle one of the most pressing and misunderstood topics in oral health today: the harms of vaping and nicotine pouches like Zyn. Far from being "harmless alternatives," these products present significant risks that dental professionals need to understand and address. Key Topics Covered What Are Vapes and Nicotine Pouches?

Featuring perspectives from Dr Virginia F Borges, Ms Jamie Carroll, Mr Ronald Stein and Dr Seth Wander, including the following topics: Introduction (0:00) Role of CDK4/6 Inhibitors in Localized and Metastatic Hormone Receptor (HR)-Positive Breast Cancer (12:49) PI3K Inhibition as First-Line Treatment for HR-Positive, HER2-Negative Metastatic Breast Cancer (mBC) (38:24) Clinical Utility of AKT and PI3K Inhibitors in Progressive HR-Positive mBC (1:01:44) Current and Future Role of Oral Selective Estrogen Receptor Degraders in HR-Positive mBC (1:24:38) NCPD information and select publications

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Featuring perspectives from Dr Sunnie Kim, Ms Brooke Parker, Ms Michal Segal and Dr Manish Shah, including the following topics: Introduction: Clinical Presentation of Gastroesophageal Cancer (0:00) Management of Localized or Locally Advanced Gastroesophageal Cancers; Current and Future Role of Immune Checkpoint Inhibitors (21:44) Incorporation of Immunotherapeutic Strategies for HER2-Negative Metastatic Gastroesophageal Tumors (39:32) Role of Therapy Targeting CLDN18.2 in Advanced Gastric/Gastroesophageal Junction Adenocarcinoma (1:00:50) Considerations in the Care of Patients with HER2-Positive Gastroesophageal Cancers (1:22:41) NCPD information and select publications

In the podcast: Localized, boil water advisories will end if two water compliance tests come back negative — likely Thursday afternoon.

Neighborhood Niche: Mastering Hyper-Localized Marketing for Small Businesses

Send us a textSelena Gomez's latest venture, Serendipity Ice Cream, is shaking up the frozen treats industry—and today, we break down exactly how. Host Jordan West teams up with Miguel Garcia Castillo (Co Studios) to explore the brand strategy, product distribution hurdles, and the marketing playbook behind this consumer product's zero to one journey. What does it take to go from concept to cart in the competitive world of CPG? In this Fast Track episode of Ecommerce OS, Jordan and Miguel tackle the realities of launching Serendipity—an emotionally-driven, mission-aligned brand backed by Selena Gomez. From regional distribution pain points to the power of localized influencer marketing, this is a masterclass in turning a pop culture idea into a lifestyle product.Timestamps: 00:00 – Welcome to Fast Track + Jordan introduces the episode 01:45 – Meet Miguel Garcia Castillo of Co Studios 04:12 – The origin story of Serendipity Ice Cream with Selena Gomez 08:50 – From nostalgic NYC vibes to mental health advocacy 12:35 – The biggest constraint: Product availability & brand awareness 16:20 – The logistics nightmare of DTC frozen products 19:05 – Hyper-local awareness strategies: YouTube + TikTok creators 24:10 – Why brand is your moat, not just your marketing 28:30 – Profitability, commodity pricing & long-term strategy 32:00 – Closing thoughts + how to join Ecommerce OSKey Takeaways:Brand is a moat: In crowded markets, your brand values are your defense.Localized marketing > national awareness: DTC is important, but retail-first brands must win regionally.Celebrity-driven brands need more than a name: Product, price, and purpose must all deliver.Frozen DTC = hard mode: Logistics, costs, and timing matter more than ever.Storytelling wins: Emotional connection and authenticity help Serendipity stand out.Guest Info: Miguel Garcia Castillo Founder & Principal, Co Studios — Early-stage consumer venture builder — Brand strategist + growth architect for Selena Gomez's SerendipityLinkedIn:  https://www.linkedin.com/in/mgarcast/ Website: https://www.costudios.co/ “Get my 27 strategies in 27 days to work less, earn more, and grow smarter”

In this episode, I sit with long-time vulnerability management and data science experts Jay Jacobs and Michael Roytman, who recently co-founded Empirical Security.We dive into the state of vulnerability management, including:How it is difficult to quantify and evaluate the effectiveness of vulnerability prioritization and scoring schemes, such as CVSS, EPSS, KEV, and proprietary vendor prioritization frameworks, and what can be done betterSystemic challenges include setbacks in the NIST National Vulnerability Database (NVD) program, the MITRE CVE funding fiasco, and the need for a more resilient vulnerability database and reporting ecosystem.Domain-specific considerations when it comes to vulnerability identifiers and vulnerability management, in areas such as AppSec, Cloud, and Configuration Management, and using data to make more effective decisionsThe overuse of the term “single pane of glass” and some alternativesEmpirical's innovative approach to “localized” models when it comes to vulnerability management, which takes unique organizational and environmental considerations into play, such as mitigating controls, threats, tooling, and more, and how they are experimenting with this new approach for the industry

Cameron is joined by Lauren Taylor, founder and CEO of The Limited Agency, and they discuss the importance of measuring ROI in social media marketing, establishing credibility through social media, identifying red flags in social media management companies, and the effectiveness of boosting posts versus running targeted campaigns. They also explore the potential of TikTok as a marketing platform and the engagement process for new clients.Listen In!Thank you for listening to this episode of Medical Millionaire!Takeaways:Social media is crucial in the patient journey, often serving as the final touchpoint before booking.Aesthetic providers need to showcase their work and personality on social media to build credibility.The 'messy middle' concept explains the complex path from visibility to booking.Tracking social media success is challenging but essential for understanding ROI.Engagement metrics like profile visits and direct messages can indicate social media effectiveness.Building a strong organic social media presence can lead to significant increases in patient bookings.Consistency and quality in social media content are key to attracting and retaining patients.Marketing agencies should assist in managing social media interactions to enhance patient engagement.Understanding patient needs during consultations can inform social media strategies.Long-term patient retention is more valuable than one-time bookings. Measuring ROI in social media is crucial for proving success.High engagement metrics do not always translate to revenue.Content should be authentic and not just trend-driven.Analytics should guide marketing strategies and adjustments.Credibility can be established through education and showcasing results.Localized growth is more important than just follower count.Boosting posts can increase visibility but may not drive conversions.TikTok offers a cost-effective way to reach a larger audience.Engagement with potential clients should be thorough and informative.Social media should be used to educate patients, not just impress colleagues.Unlock the Secrets to Success in Medical Aesthetics & Wellness with "Medical Millionaire"Welcome to "Medical Millionaire," the essential podcast for owners and entrepreneurs inMedspas, Plastic Surgery, Dermatology, Cosmetic Dental, and Elective Wellness Practices! Dive deep into marketing strategies, scaling your medical practice, attracting high-end clients, and staying ahead with the latest industry trends. Our episodes are packed with insights from industry leaders to boost revenue, enhance patient satisfaction, and master marketing techniques.Our Host, Cameron Hemphill, has been in Aesthetics for over 10 years and has supported over 1,000 Practices, including 2,300 providers. He has worked with some of the industry's most well-recognized brands, practice owners, and key opinion leaders.Tune in every week to transform your practice into a thriving, profitable venture with expert guidance on the following categories...-Marketing-CRM-Patient Bookings-Industry Trends Backed By Data-EMR's-Finance-Sales-Mindset-Workflow Automation-Technology-Tech Stack-Patient RetentionLearn how to take your Medical Aesthetics Practice from the following stages....-Startup-Growth-Optimize-Exit Inquire Here:http://get.growth99.com/mm/

In this episode of The Parker Avery Group's "Talk Retail to Me" podcast, retail experts Marty Anderson and Mike Johnson delve into how our firm collaborated with a major theme park retailer to untangle the complexities of managing over 300 unique stores. From hyper-localized assortments to razor-thin inventory margins, these consultants detail how data, analytics, and a clear roadmap contributed to balancing customer satisfaction with operational efficiency. Episode Highlights Managing inventory across 300+ hyper-localized stores requires a fundamentally different approach than traditional retail models. Balancing customer satisfaction with inventory efficiency is possible—but it demands data-backed insights and operational precision. On-site visits, cross-functional interviews, and customized analytics were critical to uncovering actionable opportunities. Even highly successful retailers benefit from an external perspective to challenge the status quo and fine-tune strategies. Robust data availability and high client engagement dramatically accelerate the path to impactful recommendations. Resources Read the project case study: https://parkeravery.com/industry-experience/retail-inventory-management-assessment/ Learn more about Parker Avery's consulting services: https://parkeravery.com/retail-consulting/ Meet Marty Anderson: https://parkeravery.com/marty-anderson/ Meet Mike Johnson: https://parkeravery.com/mike-johnson/ Meet Tricia Gustin: https://parkeravery.com/tricia-gustin/ Listen to more Talk Retail To Me podcast episodes: https://parkeravery.com/retail-podcast/

Welcome to the ¡Qué Spooky! Podcast, where we remind you that you can make cafecito at home; you don't need a latte every day.Andrez shares the mysterious case of Buffalo Ranch. Now you may be thinking about the sauce, but this is actually a 15,000 acre ranch in Colorado, but the exact location is a secret. You're going to want to turn this one up, 'cause it gets crazy! The unexplained and other worldly events at this ranch are crazy! Localized storms, noises with no cause, malevolent floating lights that stalk the ranch are just the tip of the iceberg. Grab some chips, 'cause you're gonna wanna take a seat for this one.Email us any personal paranormal and true crime encounters and/or suggestions at: quespookypodcast@gmail.com Follow us on Instagram, TikTok, and YouTube: @quespookypodcast

Meet Ali, the CEO of GreenLight Fund and former leader of Fresh Lifelines for Youth. He joins us to share how his lived experience fuels his commitment to equity-driven leadership and community transformation.

The nation's leading media outlets largely ignored the Epstein case for decades even though they had enough to run stories. If it wasn't intrepid investigative reporters from smaller outlets and independent content creators/investigative journalists, this story would have never went anywhere.(Commercial at 10:49)To contact me:Bobbycapucci@protonmail.comSource:https://www.msnbc.com/opinion/jeffrey-epstein-s-crimes-would-have-gone-unexposed-without-local-n1274901Become a supporter of this podcast: https://www.spreaker.com/podcast/the-epstein-chronicles--5003294/support.

In this episode of Create Like The Greats, Ross dives into the evolving landscape of digital marketing in the era of artificial intelligence and large language models (LLMs). He challenges brands to rethink their approach by understanding that today's most influential "audiences" aren't just humans—they're machines. Ross outlines how AI tools like ChatGPT, Perplexity, Google's AI Overviews, and others scrape public content to generate recommendations and answers for users, and how brands can strategically position their content to become part of this intelligence loop. Whether it's SEO, Reddit commentary, or owning bottom-of-funnel content, Ross shares powerful frameworks and tactics to help your brand stay relevant, present, and impactful in the age of AI-driven search results. Key Takeaways and Insights: ​​

In this episode of the AgCulture Podcast, Jamie Luce—CEO and Co-Founder of AIR Parametric—breaks down how parametric insurance is changing the game for managing climate risks in livestock and dairy farming. He shares how their data-driven tool, Milkshake™, helps farms get fast support during extreme heat, skipping the usual hassle of filing claims. It's a simpler, smarter way to get coverage, no matter the size of the operation. Tune in now on your favorite podcast platform!Meet the guest:Jamie Luce is the CEO and Co-Founder of AIR Parametric, bringing over two decades of leadership in commercial insurance. With a career spanning Liberty Mutual, QBE, and Jewelers Mutual, he launched AIR Parametric to build new protections for agricultural businesses against extreme climate events. Luce holds deep expertise in underwriting, insurance strategy, and innovation.Connect with our guest on Social Media: LinkedInWhat you will learn:(00:00) Introduction(02:11) Parametric insurance (04:42) Heat index triggers(07:07) Localized data models(10:24) Pricing and policy tiers(17:09) Rise of alt insurance(22:25) Closing thoughtsDiscover the world of agriculture with the "Ag Culture Podcast".  This podcast will be a gateway for those passionate about agriculture to explore its global perspectives and innovative practices.Join Paul as he shares his experiences in the agricultural industry, his travels and encounters with important figures around the world.Available on YouTube, Spotify and Apple Podcasts.Subscribe at ⁠http://www.agculturepodcast.com⁠ and keep an eye out for future episodes, bringing insights and stories from the vibrant world of agriculture.

In this episode, Chris Maffeo speaks to Racheal Vaughan Jones and discusses how Compass Box has positioned itself as "whisky makers" in the Scotch whisky industry. Founded in 2000 with a mission to make the Scotch world more interesting, Compass Box balances mastery and imagination in its brand essence.Recently, the company streamlined its core range into a more intuitive collection of four distinct flavor territories while maintaining its artistic limited editions.Racheal shares insights into its recent brand positioning, "Long Live Interesting," and how it has successfully translated it through packaging, communication, and targeted campaign activations across key cities.The brand's recent award-winning "Hedonism" limited edition showcases its collaboration with female artists and embodies its philosophy of starting with an organically evolving idea.Timestamps:00:00 Introduction and Welcome00:30 Special Guest Introduction01:53 The Story of Compass Box04:23 Brand Positioning and Marketing10:29 Core Range and Consumer Experience14:29 Limited Editions and Awards20:05 Limited edition approach with Hedonism26:06 Communication and Marketing Strategies30:30 Localized activation and content strategy33:45 Creating demand and brand-building philosophy

In this episode, Jethro Jones interviews Brent Zirkel, the elementary principal at Mary Welsh Elementary in Williamsburg, Iowa. They discuss how Brent is utilizing artificial intelligence to create curriculum tailored for his students. The conversation covers a range of topics including the advantages of AI in organizing content, creating engaging learning activities, and facilitating high-level thinking. Brent shares his experiences and insights on curating educational materials that resonate with both students and the community, and the importance of transparency in education.Importance of curriculum being transparentMaking sure parents know exactly what we are teaching. Web sites for classroom. If you put yourself out there in the public, it motivates you to create more and better things. https://Raidersocialstudies.com AI makes it easier to organize your thoughts and put it in a systemic way. 80/20 in work usage. Middle East UnitGives kids deeper ways to understand what is going on in the world. Not getting kids to understand facts and dates. Helping kids understand and perceive the world and make judgments. American values and patriotism are very important to our community. When you arm teachers with good curriculum you can have good discussions. Greater freedom in the discussion point because it is a discussion, not a “lesson”. Layering with AI - Using multiple technologies that wouldn't be possible with just one AI. AI Tools used: Suno (music), ChatGPT (art & more), MagicSchool (make it relevant), SchoolAI, assessmentsAI Tools are thought partners. How to be a transformative principal? Good Better Best, Never Let it rest till your good is better and your better is your best. About Brent Zirkel:Brent Zirkel is currently the Elementary Principal at Mary Welsh Elementary in Williamsburg, Iowa, a school of about 650 students.  He also serves as the district ELL Director, Migratory Education Program Director, and Preschool Program Director. Brent has previously served as the Associate Principal at Williamsburg Jr/Sr. High School (7-12) and Fort Madison Middle School (4-8).  Brent taught Spanish at Fort Madison High School for 12 years where he was honored for 5 consecutive years with the Terry Branstad Inspiring Teacher Award for serving as a motivational force to some of Iowa's top-performing high school students. He has a BA in Geography and Spanish Education, an MS in Interdisciplinary Studies with an emphasis in Bilingual Education (ELL), and is certified as a Pre-K-12 Administrator and Special Education Supervisor.Brent is also a co-founder of the Test Kitchen Educational Foundation: a non-profit organization that creates innovative after-school programming for rural communities in Iowa by getting youth excited about learning through engagement in academics, culinary arts, and valuable life skills.  Brent is married to Michelle, a K-6 Media Teacher, and has two children, Brevin (16) and Bram (10). Brent enjoys spending time with his family. He is an avid fan of Survivor, the TV show, and is a true believer in progress through struggle. Brent sees education as the greatest opportunity to build a better tomorrow by positively impacting the lives of his students today.

GIVEAWAY - send us a message and let us know your favorite thing about the Square Pizza Pod. We are giving away SchermCo swag to the first three people that send us a note!Welcome back to another episode of the #squarepizzapod. This week, Greg is in conversation with Christine Edwards Pitkin, Founder & CEO of Civility Localized & Civic Impact Academy. Civility Localized is a minority and woman-owned Community Engagement Consulting Firm with headquarters in Charlotte, North Carolina.In this episode: Civility LocalizedMinority and woman-owned consulting firm and its mission to help communities grow with dignity through inclusive strategies for local and state government initiativesCommunity outreach and engagementCivic Impact AcademyAn educational experience that brings local community leaders and government leaders into the same roomsStarted in 2024Launching a new cohort in September and applications open in JulyBoard Member ExperienceGenerationNation, Humane Society, and QC Family Tree Best practices of high-performing boards?What aspiring board members knowBe ready and willing to give of yourself - your time, your money, your contactsSupport the show

Dr. Francis Marchlinski, MD, Deputy Editor of JACC Clinical Electrophysiology, discusses Ablation Targeting Rotational Activation Pattern Around Localized Line of Conduction Block for Scar-Related Ventricular Tachycardia.

GIVEAWAY - send us a message and let us know your favorite thing about the Square Pizza Pod. We are giving away SchermCo swag to the first three people that send us a note!Welcome back to another episode of the #squarepizzapod. This week, Greg is in conversation with Christine Edwards Pitkin, Founder & CEO of Civility Localized & Civic Impact Academy. Civility Localized is a minority and woman-owned Community Engagement Consulting Firm with headquarters in Charlotte, North Carolina. In this episode: Civility LocalizedMinority and woman-owned consulting firm and its mission to help communities grow with dignity through inclusive strategies for local and state government initiativesCommunity outreach and engagement Civic Impact Academy An educational experience that brings local community leaders and government leaders into the same roomsStarted in 2024 Launching a new cohort in September and applications open in JulyBoard Member ExperienceGenerationNation, Humane Society, and QC Family TreeBest practices of high-performing boards?What aspiring board members knowBe ready and willing to give of yourself - your time, your money, your contacts Support the show

We are so excited to welcome Dr. Charles (Chuck) Ryan for our 2025 prostate cancer updates. Dr. Ryan is an internationally recognized GU oncologist and prostate cancer expert, seeing patients at Memorial Sloane Kettering in NYC. This episode will cover localized prostate cancer, risk factors, staging, role of PET PSMA, risk stratification, treatments, as well as introduce biochemical recurrence.

Featuring perspectives from Dr Thomas E Hutson, Dr Rana R McKay, Dr Sumanta Kumar Pal and Dr Tian Zhang, moderated by Dr Pal, including the following topics: Introduction (0:00) Immunotherapeutic Strategies for Localized and Metastatic Clear Cell Renal Cell Carcinoma (RCC) — Dr Hutson (2:34) Optimal Management of Relapsed/Refractory RCC — Dr Zhang (32:49) Role of HIF-2α Inhibitors in the Treatment of Sporadic and von Hippel-Lindau-Associated RCC — Dr McKay (1:04:02) Current and Future Care of Patients with Non-Clear Cell RCC — Dr Pal (1:33:13) CME information and select publications

Featuring perspectives from Dr Scott Kopetz and Dr Jeffrey Meyerhardt, including the following topics: Introduction (0:00) Cell-Free DNA Molecular Residual Disease Assays in Clinical Practice (3:25) Immunotherapy for Localized and Metastatic Microsatellite Instability-High Colorectal Cancer (28:27) Other Important Datasets (46:06) CME information and select publications

Dr Kevin S Hughes from the Medical University of South Carolina in Charleston and Dr Mark Robson from Memorial Sloan Kettering Cancer Center in New York discuss current BRCA1/2 genetic testing practices and the clinical management of localized breast cancer with alterations in these genes. CME information and select publications here.

Featuring perspectives from Dr Kevin S Hughes and Dr Mark Robson, including the following topics: Introduction (0:00) Optimal Approach to Genetic Testing for Patients with Localized Breast Cancer (BC) — Dr Hughes (10:22) Available Data with and Practical Application of PARP Inhibition as Adjuvant Therapy for Patients with BC — Dr Robson (38:06) CME information and select publications

Dr Kevin S Hughes from the Medical University of South Carolina in Charleston and Dr Mark Robson from Memorial Sloan Kettering Cancer Center in New York discuss current BRCA1/2 genetic testing practices and the clinical management of localized breast cancer with alterations in these genes. CME information and select publications here.

Prostate cancer is the most common nonskin cancer in men in the US and the second most common cancer in men worldwide. Author R. Bruce Montgomery, MD, of the University of Washington joins JAMA Senior Editor Karen Lasser, MD, MPH, to discuss the current evidence regarding the epidemiology, diagnosis, and management of localized and metastatic prostate cancer. Related Content: Prostate Cancer

Today's episode is focusing on what you need to know regarding early stage colorectal cancer (CRC) as of 2025. The last time we covered this topic was in 2023 and things continue to change. We will go over all the important details on the diagnosis, presentation, diagnostic work-up, role of ctDNA, staging, treatment, and surveillance of localized CRC. 

At the heart of The Prophets' vision are “The 24 Essential Supply Chain Processes.” What are they? Find out, and see the future yourself. Click here The automotive supply chain isn't what it used to be. Between shifting global policies, evolving AI capabilities, and the relentless push for sustainability, the pressure is on. And if you're not thinking ahead, you're already behind. But Martinrea is ahead of the curve, and in this episode, Megan Hunter, Executive VP of Procurement and Supply Chain Operations, explains how.One of the biggest game-changers? AI. Forget spending hours digging through Google for the right supplier. AI-powered tools now make instant supplier recommendations, cut through the noise, and even challenge old-school procurement tactics. But AI isn't perfect—Megan shares the hidden risks that supply chain leaders must watch out for.Then there's supplier transparency, a topic everyone talks about but few have mastered. Why? Because transparency isn't a tech problem—it's a trust problem. Megan reveals the reality of deep-tier supplier mapping, the struggle to get reliable data, and the cultural shift needed to make transparency a reality.And let's talk about sustainability—not as a checkbox, but as a game-changing strategy. At Martinrea, it's not just about the planet; it's about saving millions. Localized sourcing? 300,000 fewer miles traveled. Smart packaging? Less waste, lower costs.Of course, none of this works without the right people in place. However, the auto industry faces a massive talent gap. Megan's solution? Don't wait for talent—build it. Martinrea is launching an industry-first supply chain apprenticeship program, pulling in fresh talent from the ground up and training them in everything from procurement to AI-driven analytics.And if you're feeling overwhelmed by all of this? Megan's advice is simple: start with quick wins. Instead of getting stuck in the complexity, take immediate, tangible steps to drive change.Themes discussed in this episode:How Martinrea is using AI to streamline supplier searches and procurementThe biggest challenges in supplier transparency and why trust is the missing linkWhy sustainability is not just good for the planet but a cost-saving strategyThe role of zero landfill initiatives in Martinrea's waste reduction effortsWhy real supply chain transformation requires cultural shifts, not just technologyHow Martinrea is addressing the supply chain talent gap with an apprenticeship programThe importance of quick wins in driving supply chain innovation and progressFeatured on this episode:Name: Megan HunterTitle: Executive Vice President Procurement and Supply Chain Operations at Martinrea InternationalAbout: Megan is the Executive Vice President of Procurement and Supply Chain Operations at Martinrea International Inc., a role she has held since December 2019. She leads the company's global procurement and supply chain strategy, ensuring sustainable and efficient operations across the organization. In addition to overseeing procurement, Megan is also responsible for the Auburn Hills Technical Center and Martinrea's sustainability initiatives.Connect: LinkedInMentioned in this episode:Microsoft Copilot: Your AI companion

What are some lessons to be learned after last nights Super Bowl?

ITL Hour 2: Around The NFL, More reaction to the Super Bowl, Aaron Rodgers done in NY, & more. What are some lessons to be learned after last nights Super Bowl? What's Popping, Rockets continues to struggle, Hubie Brown calls it a career, & more.

Jeremy Au explored the evolving venture capital landscape in Southeast Asia by linking GDP per capita thresholds (US$5K in Vietnam, Indonesia & Philippines vs. US$94K Singapore) to the rise of unicorns like Gojek and Grab. Jeremy also explored the implications of high global interest rates, which have reshaped venture capital deployment, shifting focus toward early-stage investments while reducing late-stage funding. Lastly, he analyzed the diversification of startup models, such as Vietnam's localized mini-conglomerates and Singapore's globally focused virtualized teams, emphasizing adaptability as a key driver for success in a fragmented yet promising ecosystem. Watch, listen or read the full insight at https://www.bravesea.com/blog/gdp-per-capita-vs-unicorns Get transcripts, startup resources & community discussions at www.bravesea.com WhatsApp: https://whatsapp.com/channel/0029VakR55X6BIElUEvkN02e TikTok: https://www.tiktok.com/@jeremyau Instagram: https://www.instagram.com/jeremyauz Twitter: https://twitter.com/jeremyau LinkedIn: https://www.linkedin.com/company/bravesea English: Spotify | YouTube | Apple Podcasts Bahasa Indonesia: Spotify | YouTube | Apple Podcasts Chinese: Spotify | YouTube | Apple Podcasts Vietnamese: Spotify | YouTube | Apple Podcasts

Dr. Sue Yom, Editor in Chief, hosts guests Dr. Cristian Udovicich, a Fellow in Radiation Oncology at the University of Toronto's Sunnybrook Odette Cancer Centre, and Dr. Angela Jia, Assistant Professor and Assistant Residency Program Director at University Hospitals Cleveland Medical Center, who were the first and second authors of "Evolving Paradigms in Prostate Cancer: The Integral Role of Prostate-Specific Membrane Antigen Positron Emission Tomography/Computed Tomography in Primary Staging and Therapeutic Decision-Making." In addition, we review long-term SBRT results with Dr. Andrew Loblaw, Full Professor in the Department of Radiation Oncology and Institute of Health Policy, Management and Evaluation at Sunnybrook Health Science Center at the University of Toronto and supervising author of "Stereotactic Radiation Therapy for Localized Prostate Cancer: 10-Year Outcomes From Three Prospective Trials," and Dr. Constantinos Zamboglou, Deputy Medical Director at the German Oncology Center in Limassol, Cyprus and first author of an accompanying editorial, "Stereotactic Body Radiotherapy for Prostate Cancer is Getting Mature: 10-Year Outcomes From Three Prospective Trials."

In this solo episode, Jean-Martin Fortier dives into the evolving landscape of sustainable farming, exploring the differences and connections between organic, regenerative, and small-scale agriculture. He highlights the importance of maintaining organic certification to ensure transparency and accountability while addressing concerns about greenwashing in the regenerative movement. JM emphasizes the need for localized, decentralized farming systems rooted in healthy soils and human-scale operations, advocating for unity within the movement to combat the challenges posed by industrialized agriculture.  If this episode inspires you to rethink the possibilities of small-scale farming, we invite you to take it a step further. From January 14 to 16, join our FREE and LIVE workshop Money Talks where we'll dive into the numbers behind real farms. This practical and inspiring event will show how small farms can be both a solution and a profitable path forward. Register here: https://themarketgardener.easywebinar.live/event-registration-jan-2025 PLEASE make sure to subscribe to the podcast, download our episodes, and rate them! Your support means the world to us. Thank you! Timestamps [6:40] Evolution of organic farming: From pioneers to present day [10:09] Regenerative agriculture: The new buzzword [13:13] Greenwashing concerns: Loosely defined standards [15:29] Organic certification: Why it still matters [16:49] Scale in agriculture: Localized versus industrialized [20:24] Soil and scale: Core to sustainable farming [22:01] Movement clarity: Avoiding manipulation and staying united [23:28] Economic impact: Local farms as community drivers [24:23] Workshop announcement: “Money Talks” free event in January Sponsors Tessier  Use promocode MGI10 for 10% off and free shipping on your first purchase for the Eastern North American regions (Ontario, the Maritimes, and the states of Vermont, Maine, New York, and New Hampshire).  Market Gardener Institute⁠  Join the Masterclass waiting list! Bootstrap  https://bootstrapfarmer.com/marketgardenerpodcast Links/Resources Market Gardener Institute:  https://themarketgardener.com/  Masterclass:  https://themarketgardener.com/courses/the-market-gardener-masterclass/  Newsletter:  https://themarketgardener.com/newsletter Blog:  https://themarketgardener.com/blog  Books: https://themarketgardener.com/books Growers & Co: https://growers.co/ Heirloom: https://heirloom.ag/ The Old Mill: https://www.espaceoldmill.com/en/ Follow Us Website: http://themarketgardener.com  Facebook: http://facebook.com/marketgardenerinstitute  Instagram: http://instagram.com/themarketgardeners  Guest Social Media Links JM: Instagram: https://www.instagram.com/jeanmartinfortier Facebook: https://www.facebook.com/jeanmartinfortier 

Guest: Dr. Christian de Virgilio is the Chair of the Department of Surgery at Harbor-UCLA Medical Center. He is also Co-Chair of the College of Applied Anatomy and a Professor of Surgery at UCLA's David Geffen School of Medicine. He completed his undergraduate degree in Biology at Loyola Marymount University and earned his medical degree from UCLA. He then completed his residency in General Surgery at UCLA-Harbor Medical Center followed by a fellowship in Vascular Surgery at the Mayo Clinic.   Resources:  Rutherford Chapters (10th ed.): 174, 175, 177, 178 Prior Holding Pressure episode on AV access creation: https://www.audiblebleeding.com/vsite-hd-access/ The Society for Vascular Surgery: Clinical practice guidelines for the surgical placement and maintenance of arteriovenous hemodialysis access: https://www.jvascsurg.org/article/S0741-5214%2808%2901399-2/fulltext  KDOQI Clinical Practice Guideline for Vascular Access: 2019 Update: https://pubmed.ncbi.nlm.nih.gov/32778223/    Outline: Steal Syndrome Definition & Etiology Steal syndrome is an important complication of AV access creation, since access creation diverts arterial blood flow from the hand. Steal can be caused by multiple factors—arterial occlusive disease proximal or distal to the AV anastomosis, high flow through the fistula at the expense of distal arterial perfusion, and failure of the distal arterial networks to adapt to this decreased blood flow.  Incidence and Risk Factors The frequency of steal syndrome is 1.6-9%1,2, depending on the vessels and conduit choice Steal syndrome is more common with brachial and axillary artery-based accesses and nonautogenous conduits. Other risk factors for steal syndrome are peripheral vascular disease, coronary artery disease, diabetes, advanced age, female sex, larger outflow conduit, multiple prior permanent access procedures, and prior episodes of steal.3,4  Long-standing insulin-dependent diabetes causes both medial calcinosis and peripheral neuropathy, which limits arteries' ability to vasodilate and adjust to decreased blood flow. Patient Presentation, Symptoms, Grading Steal syndrome is diagnosed clinically.  Symptoms after AVG creation occurs within the first few days, since flow in prosthetic grafts tend to reach a maximum value very early after creation. Native AVFs take time to mature and flow will slowly increase overtime, leading to more insidious onset of symptoms that can take months or years. The patient should have a unilateral complaint in the extremity with the AV access. Symptoms of steal syndrome, in order of increasing severity, include nail changes, occasional tingling, extremity coolness, numbness in fingertips and hands, muscle weakness, rest pain, sensory and motor deficits, fingertip ulcerations, and tissue loss.  There could be a weakened radial pulse or weak Doppler signal on the affected side, and these will become stronger after compression of the AV outflow. Symptoms are graded on a scale specified by Society of Vascular Surgery (SVS) reporting standards:5  Workup Duplex ultrasound can be used to analyze flow volumes. A high flow volume (in autogenous accesses greater than 800 mL/min, in nonautogenous accesses greater than 1200 mL/min) signifies an outflow issue. The vein or graft is acting as a pressure sink and stealing blood from the distal artery. A low flow volume signifies an inflow issue, meaning that there is a proximal arterial lesion preventing blood from reaching the distal artery. Upper extremity angiogram can identify proximal arterial lesions. Prevention Create the AV access as distal as possible, in order to preserve arterial inflow to the hand and reduce the anastomosis size and outflow diameter.  SVS guidelines recommend a 4-6mm arteriotomy diameter to balance the need for sufficient access flow with the risk of steal. If a graft is necessary, tapered prosthetic grafts are sometimes used in patients with steal risk factors, using the smaller end of the graft placed at the arterial anastomosis, although this has not yet been proven to reduce the incidence of steal.  Indications for Treatment Intervention is recommended in lifestyle-limiting cases of Grade II and all Grade III steal cases. If left untreated, the natural history of steal syndrome can result in chronic limb ischemia, causing gangrene with loss of digits or limbs. Treatment Options Conservative management relies on observation and monitoring, as mild cases of steal syndrome may resolve spontaneously. Inflow stenosis can be treated with endovascular intervention (angioplasty with or without stent) Ligation is the simplest surgical treatment, and it results in loss of the AV access. This is preferred in patients with repetitive failed salvage attempts, venous hypertension, and poor prognoses. Flow limiting procedures can address high volumes through the AV access. Banding can be performed with surgical cutdown and placement of polypropylene sutures or a Dacron patch around the vein or graft. The Minimally Invasive Limited Ligation Endoluminal-Assisted Revision (MILLER) technique employs a percutaneous endoluminal balloon inflated at the AVF to ensure consistency in diameter while banding Plication is when a side-biting running stitch is used to narrow lumen of the vein near the anastomosis. A downside of flow-limiting procedures is that it is often difficult to determine how much to narrow the AV access, as these procedures carry a risk of outflow thrombosis. There are also surgical treatments focused on reroute arterial inflow. The distal revascularization and interval ligation (DRIL) procedure involves creation of a new bypass connecting arterial segments proximal and distal to the AV anastomosis, with ligation of the native artery between the AV anastomosis and the distal anastomosis of the bypass. Reversed saphenous vein with a diameter greater than 3mm is the preferred conduit. Arm vein or prosthetic grafts can be used if needed, but prosthetic material carries higher risk of thrombosis. The new arterial bypass creates a low resistance pathway that increases flow to distal arterial beds, and interval arterial ligation eliminates retrograde flow through the distal artery.  The major risk of this procedure is bypass thrombosis, which results in loss of native arterial flow and hand ischemia. Other drawbacks of DRIL include procedural difficulty with smaller arterial anastomoses, sacrifice of saphenous or arm veins, and decreased fistula flow. Another possible revision surgery is revision using distal inflow (RUDI). This procedure involves ligation of the fistula at the anastomosis and use of a conduit to connect the outflow vein to a distal artery. The selected distal artery can be the proximal radial or ulnar artery, depending on the preoperative duplex. The more dominant vessel should be spared, allowing for distal arterial beds to have uninterrupted antegrade perfusion. The nondominant vessel is used as distal inflow for the AV access. RUDI increases access length and decreases access diameter, resulting in increased resistance and lower flow volume through the fistula. Unlike DRIL, RUDI preserves native arterial flow.  Thrombosis of the conduit would put the fistula at risk, rather than the native artery.  The last surgical revision procedure for steal is proximalization of arterial inflow (PAI). In this procedure, the vein is ligated distal to the original anastomosis site and flow is re-established through the fistula with a PTFE interposition graft anastomosed end-to-side with the more proximal axillary artery and end-to-end with the distal vein. Similar to RUDI, PAI increases the length and decreases the diameter of the outflow conduit. Since the axillary artery has a larger diameter than the brachial artery, there is a less significant pressure drop across the arterial anastomosis site and less steal. PAI allows for preservation of native artery's continuity and does not require vein harvest.  Difficulties with PAI arise when deciding the length of the interposition graft to balance AV flow with distal arterial flow. 2. Ischemic Monomelic Neuropathy Definition Ischemic monomelic neuropathy (IMN) is a rare but serious form of steal that involves nerve ischemia. Severe sensorimotor dysfunction is experienced immediately after AV access creation. Etiology IMN affects blood flow to the nerves, but not the skin or muscles because peripheral nerve fibers are more vulnerable to ischemia. Incidence and Risk Factors IMN is very rare; it has an estimated incidence of 0.1-0.5% of AV access creations.6 IMN has only been reported in brachial artery-based accesses, since the brachial artery is the sole arterial inflow for distal arteries feeding all forearm nerves. IMN is associated with diabetes, peripheral vascular disease, and preexisting peripheral neuropathy that is associated with either of the conditions. Patient Presentation Symptoms usually present rapidly, within minutes to hours after AV access creation. The most common presenting symptom is severe, constant, and deep burning pain of the distal forearm and hand. Patients also report impairment of all sensation, weakness, and hand paralysis. Diagnosis of IMN can be delayed due to misattribution of symptoms to anesthetic blockade, postoperative pain, preexisting neuropathy, a heavily bandaged arm precluding neurologic examination. Treatment Treatment is immediate ligation of the AV access. Delay in treatment will quickly result in permanent sensorimotor loss.   3. Perigraft Seroma Definition A perigraft seroma is a sterile fluid collection surrounding a vascular prosthesis and is enclosed within a pseudomembrane. Etiology and Incidence Possible etiologies include: transudative movement of fluid through the graft material, serous fluid collection from traumatized connective tissues (especially the from higher adipose tissue content in the upper arm), inhibition of fibroblast growth with associated failure of the tissue to incorporate the graft, graft “wetting” or kinking during initial operation, increased flow rates, decreased hematocrit causing oncotic pressure difference, or allergy to graft material. Seromas most commonly form at anastomosis sites in the early postoperative period. Overall seroma incidence rates after AV graft placement range from 1.7–4% and are more common in grafts placed in the upper arm (compared to the forearm) and Dacron grafts (compared to PTFE grafts).7-9 Patient Presentation and Workup Physical exam can show a subcutaneous raised palpable fluid mass Seromas can be seen with ultrasound, but it is difficult to differentiate between the types of fluid around the graft (seroma vs. hematoma vs. abscess) Indications for Treatment Seromas can lead to wound dehiscence, pressure necrosis and erosion through skin, and loss of available puncture area for hemodialysis Persistent seromas can also serve as a nidus for infection. The Kidney Disease Outcomes Quality Initiative (KDOQI) guidelines10 recommend a tailored approach to seroma management, with more aggressive surgical interventions being necessary for persistent, infected-appearing, or late-developing seromas.   Treatment The majority of early postoperative seromas are self-limited and tend to resolve on their own Persistent seromas have been treated using a variety of  methods-- incision and evacuation of seroma, complete excision and replacement of the entire graft, and primary bypass of the involved graft segment only. Graft replacement with new material and rerouting through a different tissue plane has a higher reported cure rate and lower rate of infection than aspiration alone.9     4. Infection Incidence and Etiology The reported incidence of infection ranges 4-20% in AVG, which is significantly higher than the rate of infection of 0.56-5% in AVF.11  Infection can occur at the time of access creation (earliest presentation), after cannulation for dialysis (later infection), or secondary to another infectious source. Infection can also further complicate a pre-existing access site issue such as infection of a hematoma, thrombosed pseudoaneurysm, or seroma. Skin flora from frequent dialysis cannulations result in common pathogens being Staphylococcus, Pseudomonas, or polymicrobial species. Staphylococcus and Pseudomonas are highly virulent and likely to cause anastomotic disruption. Patient Presentation and Workup Physical exam will reveal warmth, pain, swelling, erythema, induration, drainage, or pus. Occasionally, patients have nonspecific manifestations of fever or leukocytosis. Ultrasound can be used to screen for and determine the extent of graft involvement by the infection.   Treatments In AV fistulas: Localized infection can usually be managed with broad spectrum antibiotics.  If there are bleeding concerns or infection is seen near the anastomosis site, the fistula should be ligated and re-created in a clean field. In AV grafts: If infection is localized, partial graft excision is acceptable. Total graft excision is recommended if the infection is present throughout the entire graft, involves the anastomoses, occludes the access, or contains particularly virulent organisms Total graft excision may also be indicated if a patient develops recurrent bacteremia with no other infectious source identified. For graft excision, the venous end of the graft is removed and the vein is oversewn or ligated. If the arterial anastomosis is intact, a small cuff of the graft can be left behind and oversewn. If the arterial anastomosis is involved, the arterial wall must be debrided and ligation, reconstruction with autogenous patch angioplasty, or arterial bypass can be pursued. References   1. Morsy AH, Kulbaski M, Chen C, Isiklar H, Lumsden AB. Incidence and Characteristics of Patients with Hand Ischemia after a Hemodialysis Access Procedure. J Surg Res. 1998;74(1):8-10. doi:10.1006/jsre.1997.5206 2. Ballard JL, Bunt TJ, Malone JM. Major complications of angioaccess surgery. Am J Surg. 1992;164(3):229-232. doi:10.1016/S0002-9610(05)81076-1 3. Valentine RJ, Bouch CW, Scott DJ, et al. Do preoperative finger pressures predict early arterial steal in hemodialysis access patients? A prospective analysis. J Vasc Surg. 2002;36(2):351-356. doi:10.1067/mva.2002.125848 4. Malik J, Tuka V, Kasalova Z, et al. Understanding the Dialysis access Steal Syndrome. A Review of the Etiologies, Diagnosis, Prevention and Treatment Strategies. J Vasc Access. 2008;9(3):155-166. doi:10.1177/112972980800900301 5. Sidawy AN, Gray R, Besarab A, et al. Recommended standards for reports dealing with arteriovenous hemodialysis accesses. J Vasc Surg. 2002;35(3):603-610. doi:10.1067/mva.2002.122025 6. Thermann F, Kornhuber M. Ischemic Monomelic Neuropathy: A Rare but Important Complication after Hemodialysis Access Placement - a Review. J Vasc Access. 2011;12(2):113-119. doi:10.5301/JVA.2011.6365 7. Dauria DM, Dyk P, Garvin P. Incidence and Management of Seroma after Arteriovenous Graft Placement. J Am Coll Surg. 2006;203(4):506-511. doi:10.1016/j.jamcollsurg.2006.06.002 8. Gargiulo NJ, Veith FJ, Scher LA, Lipsitz EC, Suggs WD, Benros RM. Experience with covered stents for the management of hemodialysis polytetrafluoroethylene graft seromas. J Vasc Surg. 2008;48(1):216-217. doi:10.1016/j.jvs.2008.01.046 9. Blumenberg RM, Gelfand ML, Dale WA. Perigraft seromas complicating arterial grafts. Surgery. 1985;97(2):194-204. 10. Lok CE, Huber TS, Lee T, et al. KDOQI Clinical Practice Guideline for Vascular Access: 2019 Update. Am J Kidney Dis. 2020;75(4):S1-S164. doi:10.1053/j.ajkd.2019.12.001 11. Padberg FT, Calligaro KD, Sidawy AN. Complications of arteriovenous hemodialysis access: Recognition and management. J Vasc Surg. 2008;48(5):S55-S80. doi:10.1016/j.jvs.2008.08.067

What happens when a Marine who battled Al-Qaeda in Iraq returns home to find his biggest enemy isn't a foreign power, but the division within his own country? And what if he teams up with an Army Cavalry officer who dodged IEDs in Baghdad to fight that enemy? This isn't a Tom Clancy thriller; this is the real-life story of Jake Harriman and Garrett Cathcart, the founders of +More Perfect Union. They're on a mission to bridge the political divide tearing America apart, one community at a time. Join us as we delve into their incredible journeys from combat zones to the front lines of a different kind of war – the battle to bring America together.Check out the full series of "Career Sessions, Career Lessons" podcasts here or visit pathwise.io/podcast/. A full written transcript of this episode is also available at https://pathwise.io/podcasts/garrett-cathcart-and-jake-harriman/.Become a PathWise member today! Join at https://pathwise.io/join-now/

We sit down with Brandon Kuipers, Co-founder and CMO of Zox, to discuss how a family arts-and-crafts project evolved into a globally recognized e-commerce brand. Hear how Zox grew from a family project to an international success by leveraging data-driven marketing, and how emerging tools like Triple Whale's Sonar have unlocked global markets. From Kitchen Table to Global BrandKey takeaways:Leveraging the right data tools, like Sonar, significantly improved Zox's data visibility, enabling them to optimize ad performance in international markets.Localized strategies, like creating region-specific products such as language-adapted designs, can help deepen market engagement.[00:06:32] “Building a business is about innovating, even when you feel like you have it figured out.” — Brandon[00:17:54] Once Sonar was set up, our data accuracy went from tracking almost none of our conversions to tracking just about every conversion." — Brandon[00:20:30] “Sonar has been the missing link, reopening markets we thought had closed down.” — Brandon[00:25:18] “Even if an ad flops in the U.S., it can still perform well in other regions. Nothing is wasted.” — Brandon[00:28:30] “This level of visibility is enabling full-on product pivots to better address new markets.” — Brian Associated Links:Learn more about Sonar, Triple Whale's Meta Integration.Check out Future Commerce on YouTubeCheck out Future Commerce+ for exclusive content and save on merch and printSubscribe to Insiders and The Senses to read more about what we are witnessing in the commerce worldListen to our other episodes of Future CommerceHave any questions or comments about the show? Let us know on futurecommerce.com, or reach out to us on Twitter, Facebook, Instagram, or LinkedIn. We love hearing from our listeners!

Thanks to the isoxazolines... we don't see demodex as much as we used to! However, it is still a disease that can be overlooked and important to recognize and treat. But when treatment can range from nothing to an anti-parasitic... how do you approach these canine cases?Localized vs. GeneralizedJuvenile-onset vs. Adult-onsetDid you know there are three types of Demodex we can find on dogs?Find out more on this week's episode of The Derm Vet podcast!TIMESTAMPS00:00 Intro00:25 Why I'm in Thailand00:45 Canine Demoidicosis04:02 Demodex Canis04:24 Demodex Cornei05:09 Demodex Injai06:54 Classification of Demodicosis09:25 Juvenile Onset vs Adult Onset11:34 How We Diagnose Demodicosis13:38 Treatment for Demodicosis15:24 Outro

In Episode 2 of the Anti-Trans Hate Machine, Imara Jones explores how paramilitary groups like Patriot Front are modernizing and intensifying their anti-LGBTQ tactics. Working in tandem with local politicians, right-wing think tanks, and influential online actors like Libs of Tik-Tok, these groups are radicalizing American politics from the ground up, weaponizing transphobia to destabilize local communities. In this episode we'll show how these dangerous synergies are spreading and learn about how Idaho is the testing ground for this new wave of far-right extremism, raising urgent questions about the future of democracy in America.To learn more, visit translash.org/ATHM. Follow TransLash Media @translashmedia on Instagram, Threads, X, and Facebook.Follow Imara Jones on X (@ImaraJones) and Instagram (@Imara_jones_)The Anti-Trans Hate Machine is produced by TransLash Media. Hosted on Acast. See acast.com/privacy for more information.

Audio of Jeremy Rutherford talking about the ramifications of the Robert Thomas injury. Townies. St. Louis's own AJ McCarron talking about the current state of Alabama Football. Brianna ChickenFry and Zach Bryan have split. Taking breakups public. Social media breaks. Monetizing views on social media. Localized stories in the Post-Dispatch. Iggy airing grievances with Parkway North. Chris Hrabe audio postcard. Kangaroo pouches. Did Iggy ask the Hubbard receptionist to print out directions to a married listeners' wife's house? Learn more about your ad choices. Visit podcastchoices.com/adchoices

Audio of Jeremy Rutherford talking about the ramifications of the Robert Thomas injury. Townies. St. Louis's own AJ McCarron talking about the current state of Alabama Football. Brianna ChickenFry and Zach Bryan have split. Taking breakups public. Social media breaks. Monetizing views on social media. Localized stories in the Post-Dispatch. Iggy airing grievances with Parkway North. Chris Hrabe audio postcard. Kangaroo pouches. Did Iggy ask the Hubbard receptionist to print out directions to a married listeners' wife's house? Learn more about your ad choices. Visit podcastchoices.com/adchoicesSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Localized terrorist attacks are a terrifying but real possibility in today's world. They may not make global headlines, but their impact on the lives of those affected can be profound. These events often target public areas where everyday people gather—places you might go without a second thought. Preparing for such a scenario is not about… The post How to Survive Localized Terrorist Attacks appeared first on Mind4Survival.