Podcasts about red blood cells

In this World Shared Practice Forum podcast, Dr. Dennis Daniel discusses pediatric extracorporeal life support (ECLS) with experts Drs. Peta Alexander and Ryan Barbaro. They explore the differences between pediatric and adult extracorporeal cardiopulmonary resuscitation (ECPR), highlighting differing causes of cardiac arrest and the interpretation of recently published studies. The discussion also covers supply chain issues affecting ECMO availability, the importance of standardized, evidence-based practices to identifying ECMO-associated complications, and opportunities for future research into ECMO use and outcomes. LEARNING OBJECTIVES - Identify the key differences between pediatric and adult extracorporeal cardiopulmonary resuscitation (ECPR), focusing on technical challenges and typical causes of cardiac arrest - Discuss the challenges facing standardization of pediatric ECMO care, including supply chain issues and approaches to capturing and classifying ECMO-associated complications - Describe areas of need and opportunity for future research in pediatric ECMO AUTHORS Peta Alexander, MBBS, FRACP, FCICM Senior Associate Cardiologist Director of ECMO Program Boston Children's Hospital Associate Professor in Pediatrics Harvard Medical School Ryan Barbaro, MD, MSc Service Chief of Pediatric Critical Care Medicine Director of Pediatric ECMO C.S. Mott Children's Hospital Clinical Associate Professor in Pediatric Critical Care University of Michigan Dennis Daniel, MD ECMO Medical Director, Medical-Surgical ICU Associate Director, OPENPediatrics Boston Children's Hospital DATE Initial publication date: January 27, 2025. ARTICLES REFERENCED AND ADDITIONAL RESOURCES - Alexander PMA, Di Nardo M, Combes A, et al. Definitions of adverse events associated with extracorporeal membrane oxygenation in children: results of n international Delphi process from the ECMO-CENTRAL ARC. Lancet Child Adolesc Health. 2024;8(10):773-780. https://pubmed.ncbi.nlm.nih.gov/39299748/ - UK collaborative randomised trial of neonatal extracorporeal membrane oxygenation. UK Collaborative ECMO Trail Group. Lancet. 1996;348(9020):75-82. https://pubmed.ncbi.nlm.nih.gov/8676720/ - Biomarkers of Brain Injury in Critically-Ill Children on Extracorporeal Membrane Oxygenation (ECMOhttps://reporter.nih.gov/project-details/10545733 - TITRE - Trial of Indication-based Transfusion of Red Blood Cells in ECMO, https://www.childrenshospital.org/clinical-trials/nct05405426 - ASCEND study: https://chear.org/our-research/projects/ascend-ards-children-and-ecmo-initiation-strategies-impact-neuro-development TRANSCRIPT https://cdn.bfldr.com/D6LGWP8S/at/bzpc2445cxrk9zch4wqvjjs5/012525_WSP_Updates_in_Pediatric_ECMO.pdf Please visit: http://www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children's Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open access, thus at no expense to the user. For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu CITATION Alexander PMA, Barbaro RP, Daniel D. Updates in Pediatric ECMO: Challenges and Opportunities. 01/2025. OPENPediatrics. Online Podcast. https://soundcloud.com/openpediatrics/updates-in-pediatric-ecmo-challenges-and-opportunities-by-p-alexander-r-barbaro-openpediatrics.

Are you finding that your HbA1c levels are elevated despite being on a low-carb, ketogenic, or even carnivore diet? Recently, my HbA1c test came back at 5.7 (just under the prediabetic range), and I knew something was off; after all, I've been following a relatively low-carb lifestyle for years, so there's no way my blood sugar should be high enough to suggest prediabetes.  In consulting with carnivore diet expert and medical doctor Shawn Baker, I learned that healthy red blood cells that live longer than average can actually skew HbA1c readings, making it appear as though you have higher blood glucose than you do. This happens because the longer your red blood cells live, the more glucose has time to attach to hemoglobin, artificially inflating your HbA1c levels. (Conversely, shorter-lived red blood cells can lead to lower readings, even in those with high blood sugar.) In this episode, I break down the science of the HbA1c test and explain how factors like red blood cell lifespan, iron deficiency, anemia, and other health conditions can all affect your hemoglobin A1c results.  Even if you have healthy blood sugar and no signs of diabetes, your HbA1c might still be higher due to these factors. In my case, despite my elevated HbA1c, my continuous glucose monitor (CGM) showed average blood glucose levels between 85 and 89 mg/dL — well within the normal range. In this episode: 00:00:00 - Intro & elevated HBA1C discovery 00:01:15 - Investigating the cause of high HBA1C 00:02:54 - Understanding HBA1C and red blood cells 00:04:19 - Dr. Shawn Baker's explanation: longer lifespan of RBCs 00:06:28 - Conclusion & next episode sneak peek Learn more: Continuous Glucose Monitoring Explained: https://michaelkummer.com/continuous-glucose-monitoring/ Levels vs. Nutrisense: CGM Comparison: https://michaelkummer.com/levels-vs-nutrisense/ Why You Should Wear a Continuous Glucose Monitor (CGM): https://www.primalshiftpodcast.com/44-why-you-should-wear-a-continuous-glucose-monitor-cgm/ How Exercise Influences Your Blood Glucose Response [Coke Challenge]: https://www.youtube.com/watch?v=iIiuRoKtq1s Use the code YOUTUBE10 to get 10% off your order of Grass-Fed Beef Liver supplements at https://shop.michaelkummer.com Affordable At-Home Blood Testing with SiPhox Health: https://www.youtube.com/watch?v=R7qRLzBcp94 Get 20% off your SiPhox Health purchase with the code MICHAELKUMMER at: https://michaelkummer.com/go/siphoxhealth   Ultrahuman vs Oura Ring: What's the BEST Fitness and Sleep Tracker?: https://www.youtube.com/watch?v=E-vAgCh22zk Thank you to this episode's sponsor, OneSkin! OneSkin's lineup of topical skin health products leverage the power of the company's proprietary OS-01 peptide to remove dead skin cells, improve collagen production, increase skin hydration and more. Check out my before and after photos in my OneSkin review and visit OneSkin here. Get 15% off with my discount code MKUMMER: https://michaelkummer.com/go/oneskinshop  Find me on social media for more health and wellness content: Website: https://michaelkummer.com/ YouTube: https://www.youtube.com/@MichaelKummer Instagram: https://www.instagram.com/primalshiftpodcast/ Reddit: https://www.reddit.com/r/michaelkummer/ Pinterest: https://www.pinterest.com/michaelkummer/ Twitter/X: https://twitter.com/mkummer82 Facebook: https://www.facebook.com/realmichaelkummer/ [Medical Disclaimer] The information shared on this video is for educational purposes only, is not a substitute for the advice of medical doctors or registered dietitians (which I am not) and should not be used to prevent, diagnose, or treat any condition. Consult with a physician before starting a fitness regimen, adding supplements to your diet, or making other changes that may affect your medications, treatment plan, or overall health. [Affiliate Disclaimer] I earn affiliate commissions from some of the brands and products I review on this channel. While that doesn't change my editorial integrity, it helps make this channel happen. If you'd like to support me, please use my affiliate links or discount code. #PrimalShift #OptimalHealth #AncestralLiving #Biohacking #HBA1C   

In this week's episode of The Metabolic Classroom, Dr. Ben Bikman clarifies misconceptions about lactate metabolism, emphasizing that there is no lactic acid in the human body—only lactate.He explains that lactate is the end product of non-oxidative glycolysis, produced when cells, particularly muscles and red blood cells, require quick ATP energy. Dr. Bikman highlights that lactate production occurs during high-intensity activities where energy demand exceeds the capacity of mitochondria to generate ATP efficiently.Contrary to popular belief, lactate is not responsible for muscle soreness or fatigue.Ben delves into the history of lactate research, mentioning key contributors like Otto Meyerhoff, who identified lactate as a product of anaerobic metabolism, and Carl and Gerty Cori, who discovered the Cori cycle. This cycle demonstrates how lactate is recycled by the liver into glucose, which can then be used by muscles for energy. Lactate, once considered a waste product, is now understood to be an essential substrate for gluconeogenesis.Dr. Bikman introduces George Brooks' lactate shuttle theory, which reveals that lactate is a viable energy source that can be directly utilized by mitochondria for fuel. He explains that this discovery revolutionized the understanding of lactate, showing it can be oxidized within cells for energy production rather than merely being excreted as a waste product.Dr. Bikman also discusses lactate's potential in clinical contexts, such as traumatic brain injury (TBI) recovery, where lactate can serve as an alternative energy source for the brain when glucose metabolism is impaired. Moreover, he touches on how lactate influences fat cells, promoting mitochondrial uncoupling and aiding in fat burning, contributing to metabolic health. Ben suggests that continuous lactate monitoring could help identify mitochondrial dysfunction and predict type 2 diabetes risk.https://www.insuliniq.com 00:00 - Introduction to Lactate Metabolism01:09 - Lactic Acid vs. Lactate: Debunking the Myth02:16 - Glycolysis and Lactate Production04:23 - How Lactate is Produced in Muscles06:23 - Red Blood Cells and Lactate07:18 - History of Lactate Research: Otto Meyerhoff09:40 - The Cori Cycle: Lactate Recycled into Glucose13:54 - Lactate as a Viable Energy Source15:55 - George Brooks' Lactate Shuttle Theory18:44 - Lactate and Traumatic Brain Injury (TBI)20:55 - Lactate's Role in Fat Burning and Mitochondria23:58 - Lactate in Clinical Contexts: Metabolic Health25:09 - Continuous Lactate Monitoring and Mitochondrial Dysfunction28:59 - Lactate as a Predictor of Type 2 Diabetes29:59 - Conclusion: Lactate's Critical Role in Health and EnergyBen's favorite meal-replacement shake: https://gethlth.com (discount: BEN10)Ben's favorite electrolytes (and more): https://redmond.life (discount: BEN15)Ben's favorite allulose source: https://rxsugar.com (discount: BEN20)References:Due to character length constraints, references are not posted here. However, for a complete list, we respond quickly. Please email: support@insuliniq.com with your request, and be sure to mention which Metabolic Classroom episode you are referring to. Hosted on Acast. See acast.com/privacy for more information.

Today, I am blessed to have Dr. Robert Kiltz here with me. He is the Founder and Director of CNY Fertility, one of the largest and most innovative fertility practices in the country,  with over 60% of its patients traveling from out of state or overseas to be seen. Over more than two decades of helping families grow, Dr. Kiltz has developed cutting-edge approaches to fertility grounded in Western medicine and supported by practices of holistic medicine.  In this episode, Dr. Kiltz advocates for the carnivore diet as the optimal human diet, attributing numerous health benefits to its adoption. He asserts that this diet reduces inflammation, enhances mental clarity, and aids in weight loss by eliminating plant toxins and emphasizing fatty meat consumption. Plant-based diets, high in carbohydrates, contribute to numerous health issues due to plant toxins and microbial overgrowth in the gut. Humans historically consumed animal fats and meats, essential for overall well-being. Plants have evolved mechanisms to protect themselves, making them potentially harmful when consumed by humans. Dr. Kiltz also emphasizes the importance of consuming organ meats and fatty cuts to achieve satiation and health benefits. Tune in as Dr. Kiltz argues that societal leaders, like the Pope, presidents, and dictators, use plant-based diets to control populations, making people weak and compliant. He believes consuming meat empowers individuals, making them stronger and more self-sufficient. Dr. Kiltz emphasizes that by controlling one's diet and focusing on meat consumption, individuals can achieve personal mastery and mental strength. He advocates for gratitude, love, and faith, suggesting that these principles, combined with a carnivorous diet, lead to a fulfilling and autonomous life. He also highlights the importance of fasting and maintaining a positive mindset for metabolic health. Resources from this episode:  Website: https://www.doctorkiltz.com/ Facebook: https://www.facebook.com/doctorkiltz Instagram: https://www.instagram.com/doctorkiltz/ YouTube: https://www.youtube.com/user/DrRobLive TikTok: https://www.tiktok.com/@doctorkiltz Carnivore Conversations: https://podcasts.apple.com/us/podcast/carnivore-conversations/id1645587747 The Role of Glycans in Red Blood Cells, Why Plants Are NOT As Healthy As We Thought, Undescended Testicle Tips & More: https://soundcloud.com/ben-azadi-522032578/dr-robert-kiltz-the-role-of / / E P I S O D E   S P ON S O R S   Find all of the Metabolic Freedom Sponsorship deals and coupon codes here: https://docs.google.com/document/d/1MGMtuWpaOnDU_SQbowd29DLBgp76i3GQrvDeEg2Y0co/edit?usp=sharing   Text me the words "Podcast" +1 (786) 364-5002 to be added to my contacts list.  // F O L L O W ▸ instagram | @thebenazadi | http://bit.ly/2B1NXKW ▸ facebook | /thebenazadi | http://bit.ly/2BVvvW6 ▸ twitter | @thebenazadi http://bit.ly/2USE0so ▸clubhouse | @thebenazadi Disclaimer: This podcast is for information purposes only. Statements and views expressed on this podcast are not medical advice. This podcast including Ben Azadi disclaim responsibility from any possible adverse effects from the use of information contained herein. Opinions of guests are their own, and this podcast does not accept responsibility of statements made by guests. This podcast does not make any representations or warranties about guests qualifications or credibility. Individuals on this podcast may have a direct or non-direct interest in products or services referred to herein. If you think you have a medical problem, consult a licensed physician.

In today's episode we're talking about elevated MCV (mean corpuscular volume) and why it can cause fatigue. MCV is an indication of impaired oxygen delivery. This can result in symptoms of fatigue, weakness, shortness of breath and decreased life performance. When red blood cells are small it often associated with low iron but when they are big nutritionally it is usually related to low B12, folate, thiamine, and B6. Recognize if oxygen delivery is impaired then it is really challenging for healing to occur. The next time you get a CBC check your MCV level. The goal is to have it around 88-90. We don't want it too low either as that also impairs oxygen delivery.   -------- ➡️ Get Dr. Matt's free guide to overcoming iron deficiency https://optimizeiron.com/guide/ ➡️ Schedule an iron consultation https://calendly.com/ironconsultation/60min Ask your lifestyle health questions on social media, tag @drwholeness and use #accumulatehealth. -------- Connect with Dr. Matt online:

This week we will discuss Red Blood Cell Exchange (RBCX) and Sickle Cell Disease (SCD).  Our guest is Carly Newton.   ​Carly is a Registered Nurse at Terumo Blood and Cell Technologies with over 15years helping Health Care Professionals treating SCD patients with Red Blood Cell Exchange all over the globe. Specializing in apheresis treatments, Carly uses that experience to educate Health Care Professionals on the most effective ways to prescribe Red Blood Cell Exchange.  ​By focusing on differentiating the different types of transfusion therapies available to SCD patients, Carly has been able to put the Registered Nurse degree they earned at The University of South Australia to good use. Carly may spend their days at the Terumo Lakewood campus, but it's the patients and helping them live their best lives that gets them up in the morning. ​ When they're not at Terumo, Carly loves spending time in the great outdoors and enjoying everything the Colorado Rockies have to offer.

Do you know what a G6PD deficiency is? Listen to the conversation to find out.

In this weeks episode I am sharing an old episode I made in season 1 with Amanda Burleigh, who has  helped to change maternity services by campaigning for not just delayed cord clamping, but optimal. This is where ALL the baby's blood transfers into their body, and they receive their full blood compliment. I have to say that this is a particular favourite of mine, because Amanda's story is so important to the future health of our children, and her inspirational journey has been life changing for so many.  If you would like to buy a copy of either of the books that accompany this podcast please go to your online bookseller or visit Amazon:-Labour of Love - The Ultimate Guide to Being a Birth Partner - click here:-https://bit.ly/LabourofloveThe Art of Giving Birth - Five Key Physiological Principles - https://amzn.to/3EGh9dfPregnancy Journal for 'The Art of Giving Birth' - Black and White version https://amzn.to/3CvJXmOPregnancy Journal for 'The Art of Giving Birth'- Colour version https://amzn.to/3GknbPFYou can find all my classes and courses on my website - www.sallyannberesford.co.uk Follow me on Instagram @theultimatebirthpartner Book a 1-2-1 session with Sallyann - https://linktr.ee/SallyannBeresford Please remember that the information shared with you in this episode is solely based on my own personal experiences as a doula and the private opinions of my guests, based on their own experiences. Any recommendations made may not be suitable for all listeners, so you should always do your own research before making decisions.

Die Themen in den Wissensnachrichten +++ Möglicherweise nutzbares Wasserstoff-Reservoir in Albanien entdeckt +++ Luftverschmutzung überdeckt Lock-Duftstoffe von Blüten für Bestäuber-Insekten +++ Von Amateuren gefundene Fossilien-Stätte ist für die Wissenschaft ein Volltreffer +++**********Weiterführende Quellen zu dieser Folge:Update ErdeA deep reservoir for hydrogen drives intense degassing in the Bulqizë ophiolite, Science, 08.02.2024Label-Free Digital Holotomography Reveals Ibuprofen-Induced Morphological Changes to Red Blood Cells, ACS Nanoscience Au, 05.04.2023Olfaction in the Anthropocene: NO3 negatively affects floral scent and nocturnal pollination, Science, 08.02.2024The Cabrières Biota (France) provides insights into Ordovician polar ecosystems, Nature Ecology & Evolution, 09.02.2024Alle Quellen findet ihr hier.**********Ihr könnt uns auch auf diesen Kanälen folgen: Tiktok und Instagram.

Looking 4 Healing Radio with Dr. Henry Ealy – Did you know that your amazing body makes about 2.5 Million new Red Blood Cells every second? Did you know that in your entire bloodstream, there are about 20 to 30 Trillion Red Blood Cells?! Did you know that each and every Red Blood Cell is made up of about 250 to 280 Million Hemoglobin molecules, each with the divine ability to bind Alkalizing Oxygen and...

Looking 4 Healing Radio with Dr. Henry Ealy – Did you know that your amazing body makes about 2.5 Million new Red Blood Cells every second? Did you know that in your entire bloodstream, there are about 20 to 30 Trillion Red Blood Cells?! Did you know that each and every Red Blood Cell is made up of about 250 to 280 Million Hemoglobin molecules, each with the divine ability to bind Alkalizing Oxygen and...

For National Blood Donor Month, Courtney Allison speaks with Dr. Elizabeth Stone, assistant director of transfusion medicine at NewYork-Presbyterian and Columbia. Unprecedented blood shortages mean that the need for donated blood is as critical as ever. Dr. Stone demystifies the process of giving blood, explains blood types, and shares how both the recipient and the donor can benefit from a single donation.Click here for the episode transcript.

Brian Dillon, one part of Meltybrains, released his second solo album under the moniker The Line on November 1, 2023. Entitled Red Blood Cells and Righteousness, it's an album full of collaborations, featuring Lullahush, Fehdah and Loah, Sarah Corcoran (Pillow Queens), Sorcha Richardson, Talos, God Knows and Murli, and lots more. On this episode, we talk through all the tracks on the album and discuss the making of it. Brian says: “This is an album built on personal relationships and communication, dedicated to playing a small but significant role as a part of a world so much bigger than any of us are willing to admit. After all, maybe we're all just blood cells, swimming through the veins of the earth, serving a much higher function.” On January 25 at The Horse Gallery, Dorset Street, Dublin, the exhibition White Blood Cells is opening, a sister piece to the album. A series of immersive soundscapes by Brian Dillon in collaboration with photographer Mark McGuinness. The audio-visual work explores the role and effect of supply chains in today's global world. From the press release: One of the key topics highlighted by the audio work is immigration and refuge. In 2024 global migration is taking place on a level never seen before. The work explores the West's reluctance to give shelter to people who have been driven from their homes due to economic factors which are heavily influenced by western consumer demands. If Dillon's soundscapes pose questions for the future of society, industry, and migration, McGuinness' images act as accompanying notes on our present. The images are all taken from the ongoing project, I Hope I'm Wrong, which documents the impact human activity is having on the environment. All of the images are taken in locations in Ireland which are predicted to be heavily impacted by sea level rise within the next decade. A live performance will take place on the opening night by a music group made up of migrants and asylum seekers. They will perform a short set of songs from their home countries at 6pm, Thursday 25th January 2024. Admission is free, and all are welcome to attend. You can buy Red Blood Cells and Righteousness at TheLine2.bandcamp.com

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I hope you enjoy this podcast. If you are interested in the Stem Enhance supplement I mention in the podcast then today is the start of Black Friday and you can buy one and get one tub free!https://onlinecoach.cerule.com/www/shop00:01 Blood glucose management with low carb and carnivore diets- Bart Kay and Coach Stephen discuss the importance of blood glucose management for people on low carb and carnivore diets.- Despite having well-managed blood glucose levels, some individuals may still have high HbA1c levels.02:18 Red blood cell lifespan affects HbA1c accuracy.- The finger prick test can help identify faulty glucose monitors.- Hemolytic anemia can result in artificially low HbA1c levels.06:50 High A1C levels may not be problematic if there are no spikes in blood glucose levels.- The assumption that abnormal blood glucose levels require intervention is questionable without evidence of risk of disease.09:02 Blood glucose levels show spikes and troughs, even on a low carb diet.13:22 Discussion the dismissal of real-life experiences and biases in scientific studies.- The relevance of personal experiences and the bias in funded studies are discussed.15:40 Access to life-changing health information on YouTube is being restricted.19:53 Taking stem enhance makes a significant difference in overall well-being- Stephen experimented by not taking stem enhance for six months and noticed a decline in various areas such as vision and skin vitality- After going back on stem enhance, Stephen experienced improvements in these areas, reinforcing the belief in their effectiveness21:57 Adult stem cells release exosomes containing important messages for cell function.- Exosomes contain DNA, proteins, and chemical messengers that can detect and respond to tissue conditions.- Adult stem cells play a crucial role inThank you so much for listening to my podcast. I hope you enjoyed it. Your support means the absolute world to me. And if you're enjoying the show, I've got a small favor to ask you. I'd be incredibly grateful if you would consider becoming a supporter and make a small monthly donation. Your contribution will really help to improve the show. It's a small monthly contribution. You can cancel at any time, and the link is in the show notes. Support the showAll my links in 1 easy list, including booking and personal training workout plans at LINKTREE You can now download the carnivore experience appApple direct link for apple devices Google play store direct link to app for Android Coach Stephen's Instagram Book me for coaching My growing UK carnivore YouTube channel I have set up a community that is all about eating low-carb and specifically carnivore. CLICK HERE Support my podcast from just £3 per monthBECOME A SUPPORTER Success stories Optimal Health 5 Star reviews All my facebook and other reviews are here Thanks to www.audionautix.com for any music included. Ple...

Tap in again to the physical~energetic~yogic anatomy of the 10 bodies and mindfully manage movement... Then all of a sudden, the components of your physical body begin to serve your destiny. It starts at the temple gate, and it works its way upward... ** Join The 13 Moons Community with Guru Singh and practice the new 28-Day Meditation Journey alongside heart-led members like yourself.- JOIN NOW -

Chief Medical Officer at Northwestern Medicine Central DuPage Hospital Dr. Kevin Most joins the Steve Cochran Show to discuss whether it's necessary to take time off from work for a head cold, the reasons behind the blood shortage in the United States, and why people often delay seeking medical attention until they perceive something as 'extremely wrong.' Dr. Kevin Most's Steve Cochran Show Notes: October is Breast cancer Awareness Month Breast cancer is the 2nd most common cause of Cancer among women, second only to skin cancer It makes up 30% of all new female cancers Annual cases in the US are approaching 400,000 a year. 43,000 women will die from breast cancer in the US this year Median age for breast cancer detection is 62 years old, this means that 50% of new cases of breast cancer occur in women under 62 years old. Women have a 1 in 8 chance of developing breast cancer at some time in their lives Incidence has increased slightly each year, better diagnosis? More awareness? Or environmental Breast cancer is the second leading cause of cancer death in women (lung cancer is the leading cause of cancer death in women) Breast cancer death rates have declined since 1989- results of finding cancer earlier, better treatments, screening awareness Risk factors include- alcohol consumption, obesity, sedentary lifestyle, women who have not had children, not breast feeding, hormonal therapy post menopause In May of 2023- recommendations changed to recommend that annual mammograms start at age 40 Mammogram timing at Covid and Flu shots – because of the immune response and the possible swelling of lymph nodes with the shots, many are recommending completing a screening mammogram 4-6 weeks following the vaccine The reason for this is the inflamed lymph nodes may lead to a false positive reading on a mammogram and lead to additional testing that in reality is not needed The best option is get the mammogram and then follow up with the annual vaccines, the timing should work Blood shortage- Red Cross provides about 40% of all blood in the US Red Cross has seen donations drop 25% over the past few months and is now at a critical level Versiti Blood center of Illinois is a  large donation company in the suburbs with many sites to donate Donations have declined by 25% since August- reasons include natural disasters, vacations, back to school Red Cross is pushing for allowing high schools to do blood drives again, these were stopped during the Covid pandemic This halt has not only impacted the amount of blood collected but also is seen as missing an opportunity to get new donors in line for continued donations People can donate blood every 8 weeks When you donate blood it is used in different ways- Red Blood Cells can be used for up to 30 days, Platelets which help with clotting last 5 days, Plasma which has clotting factors last up to a year as it is able to be frozen Are the fall drinks good for you Starbucks, Peet's , Dunkin Donuts, are now pushing the Fall Drinks, but do you know how they impact your nutrition Pumpkin Spice Latte   470  calories, 16g of fat and 60g of sugar – Venti or large size Perspective 2,000- 2,500 calories a day total is a goal.  60 g of Fat a day is a goal,  24 grams of sugar is a goal Christmas is right around the corner – Peppermint Mocha with whole milk- Venti – 550 calories, 22 grams for fat, 66 grams of sugar We know coffee has some great health benefits including antioxidants, decreases the risk of diabetes, decreases the risk of some cancers and may protect you from dementia, decreases the risk of depression So, Not saying stop drinking coffee just understand the health impact when adding all the flavors and sweeteners. Full Body MRI's- status symbol?  Realistic-  Kim Kardashian, Paris Hilton, Cindy Crawford touting these? Some celebrities are promoting a full body MRI  done by a company Prenuvo, saying it is life saving Some celebrities are offering discount codes The scans cost $2,500 and are not covered by insurance, The company started in 2018, touts the scan as preventive and looks for illnesses before they are detected by traditional screening. They have 8 locations across North America and will be opening 12 more. There is one in Chicago The company is pushing this test as proactive instead of reactive You can go on their website and look at the different types of cancer that their scan may be able to identify Currently each type of cancer has some screening process, when taken as a group of tests this can be cumbersome and expensive Consider colonoscopy, mammograms, PSA tests, PAP tests  these are all tests we use to identify cancers thru screening, time consuming and fragmented, but in most cases still the “gold standard” for screening. Some cancers have no screening tests currently, like pancreas, ovarian, brain, kidney, and liver. While MRI would certainly identify some of these tumors at an early stage, the MRI results are not always as accurate as one would hope  and thus lead to additional testing and risky procedures which may not be appropriate (biopsies) Currently not supported by most physicians We certainly do not have enough scanners in the US if this was going to be considered Could it help with screening for those who have put off screening?  Could it identify a cancer early in the lungs, brain or pancreas that may be lifesaving, or at least life extending? The company recommends these scans every two years Is this a technology that is just ahead of its time and will be the gold standard in the future???? With so few sites, it does come down to those who can afford the test. The test may fill the needs of a population who is looking for more information about their risk for illnesses, like genetic testing See omnystudio.com/listener for privacy information.

And then there were two... Dr. Karen & Dr. Tiffany discuss the importance of balancing work and personal life both during and "after" the pandemic.  Dr. Zanetta is taking hiatus from our usual schedule but will be back!September is Sickle Cell Awareness Month. Sickle Cell is a hereditary blood disorder that causes the red blood cells to form in a sickled or banana shape instead of the normal round shape. This change in shape makes it difficult for the red blood cells to function properly, including carrying oxygen to cells. Sickle Cell presents in two ways: Sickle Cell Trait (SCT): genetic carrier of the disease, but usually does not exhibit symptomsSickle Cell Disease (SCD): experiences symptoms such as anemia, swelling in hands and feet, pain episodes, frequent infections, or vision problemsSCD and SCT impact African Americans at disproportionate rates. Sickle Cell affects 1 million to 3 million Americans and 8 to 10 percent of African Americans. This is because SCD and SCT are an evolutionary trait that people developed in response to help protect them from malaria. As such, this condition is common in large parts of Africa. People whose ancestors are from other regions where malaria was common are also at a higher risk of inheriting SCD or SCT, including people of:Mediterranean descentMiddle Eastern descentSouth and Southeast Asian descentCentral and South American descentCaribbean descent RESOURCES:Sickle Cell VideoSickle Cell Disease.org Join the Conversation! Follow us on social media!3 Black Docsfacebook.com/3blackdocstwitter.com/3blackdocsinstagram.com/3blackdocsDr. Karen Winkfieldfacebook.com/drkarenwinkfieldtwitter.com/drwinkfieldinstagram.com/drwinkfieldDr. Zanetta Lamarfacebook.com/drzanettainstagram.com/drzanetta

Don't miss out on this week's episode of our podcast - we're diving into the duality of Beyond Red Blood Cells: Hemoglobin's Tale of Two Extremes in Preeclampsia! Our magnificent guest, Sarah Thompson, will tap into her extensive knowledge and experience to give us a comprehensive overview of this topic and how this relates to fertility challenges! Tune in for this awesome episode and soak up her invaluable insights on this incredible topic - you don't want to miss it!   Sarah Thompson is a certified functional medicine practitioner who specializes in maternity care. She is considered a leading authoritiy on the use of functional medicine in pregnancy. She is the author of the book, "Functional Maternity - Using functional medicine and nutrition to improve pregnancy and childbirth outcomes." Her book is a text book for midwifery schools, and a base for lectures and continuing education courses. When she isn't seeing patients in her Fort Collins, Colorado office, or virtually all over the world she is a consultant to Maternal Fetal Medicine, OB, Midwifery and Family Practice groups.   Follow Sarah on IG: @functional.maternity   Follow me on: Instagram: @holisticfertilitydoctor TikTok:  @holisticfertilitydoctor Youtube:  @Holistic Fertility Expert Facebook: Join our private Fertile AF tribe!  

Anemic? Tired all the time? Bruising? Spontaneous nose bleeds? Can't heal? Iron causing constipation or hemorrhoids? Is iron healthy? Red blood cells are likes trucks on the freeway. RBCs carry oxygen and nutrients to the tissues and remove waste products. Too little RBCs and it feel horrible. Too many RBC's and it feels awful. It's life! If red blood cells are healthy, then people are healthy. Too many, and traffic jams occur. Too little and exhaustion occurs. THE WORST THING IS TAKING IRON without knowing what the iron levels are. Iron is so important but also can be SOOOOO toxic. The wrong kind of iron is so bad for health. Free master class on red blood cells, iron toxicity and the breakthrough of refined plant blood infusions - a natural, safe and effective way to build the red blood cells in the body based upon 106 years of clinical experience. Here's is the link to our website if you need more information: https://www.westcliniconline.com/

Overview Red blood cells Normal Value Range Patho Special considerations Too High: Causes, Symptoms, Treatments Too Low: Causes, Symptoms, Treatments Nursing Points General Normal range Measured in millions Normal values Males 4.5-5.5 x106/mcL Females 4-4.9×106/mcL Pathophysiology Red Blood Cell generation Formed in bone marrow Stimulated by kidneys by erythropoietin Function AKA Erythrocytes Reticulocytes Young RBC Indicate regeneration Carries oxygen Via Hemoglobin Allows for transfer of CO2 Bioconcave shape Increases surface area Allows for ability to “squeeze” into capillaries 2.4 M made every 1 second Special considerations Submitted via LAVENDER top tube (EDTA) Technique can destroy red blood cells Allow vacuum in vacutainers to draw blood, never force blood into tubes Consider angiocath/IV size when drawing blood Elevated RBC results Dehydration Result of decreased plasma Polycythemia Bone marrow cancer, causes increase in RBC COPD Pulmonary fibrosis Decreased RBC results Anemia Sickle-cell ↓ EPO due to kidney disease Hemorrhage Bone marrow failure Pregnancy Assessment Assess for signs of anemia Tachycardia Fatigue Shortness of breath Decreased SaO2 Pallor Therapeutic Management Blood transfusions as necessary Treat primary cause of anemia Nursing Concepts Lab Values Oxygenation

Join us in this insightful podcast episode as we debunk common misconceptions surrounding automated red blood cell exchange (RBCX) therapy. Our guest, Carly Newton, a registered nurse specializing in apheresis treatments, will share her expertise and shed light on the truth about this unique transfusion therapy. We'll discuss the benefits of automated RBCX for both acute and chronic patients, its role in maintaining iron balance and reducing the need for chelation therapy, the convenience and potential cost savings it offers, and its impact on alloimmunization and viscosity. Carly will also delve into the findings of studies supporting the effectiveness and safety of automated RBCX. Tune in to gain a deeper understanding of this transformative treatment option and its implications for patients with sickle cell disease and other conditions. Carly Newton is a registered nurse specializing in apheresis treatments. She discusses her KevinMD article, "5 myths of treating sickle cell disease with automated red blood cell exchange." The Podcast by KevinMD is brought to you by the Nuance Dragon Ambient eXperience. Ambient intelligence augments human capabilities to make our lives easier. The applications are many, especially in health care. Ambient clinical intelligence is offsetting the most pressing challenges in health care today, such as burnout, physician shortages, physician and patient dissatisfaction, and underperforming financial outcomes, by applying the technology to clinical documentation.  The Nuance Dragon Ambient eXperience, or DAX for short, utilizes artificial intelligence and natural language processing to automatically document care. It securely listens to and captures the natural, clinician-patient encounter conversation unobtrusively, and turns that conversation into a clinical note for the clinician's review and signature directly in the electronic health record. You just talk naturally, and DAX does the rest.  DAX is being used by thousands of physicians across 30 different specialties nationwide. It has already won the Silver Stevie award in the health care technology category and was ranked #1 for improving clinician experience in KLAS's top 20 emerging solutions. VISIT SPONSOR → https://nuance.com/daxinaction SUBSCRIBE TO THE PODCAST → https://www.kevinmd.com/podcast RECOMMENDED BY KEVINMD → https://www.kevinmd.com/recommended GET CME FOR THIS EPISODE → https://earnc.me/z8HRR0 Powered by CMEfy.

Dr. Annette Bosworth, Dr. Boz, is an Internal Medicine physician, author, believer, and former faculty member with over two decades of experience assisting people in overcoming long-term, chronic diseases. She has been mentioned in various media venues, including CNN, Time, US News & World Report, and Fox News. Dr Boz enjoys giving lectures at town halls, prisons, churches, and universities and practicing medicine. She lets her faith guide her to the next chapter of her life, seeking educational moments in everything from politics to mission work. She also enjoys the experience of raising her three sons with her husband and constantly stands up for the underdog and encourages people with ongoing health issues to fight it any way they can. In this episode, Dr Boz shares her various stories and experiences throughout her medical career. Tune in as she discusses and answers questions about blood sugar, certain misconceptions about diabetes, the keto diet, and many more! Purchase Dr Boz's books here: https://amzn.to/3Wv9s0h Order Keto Flex: http://www.ketoflexbook.com -------------------------------------------------------- Download your FREE Vegetable Oil Allergy Card here: https://onlineoffer.lpages.co/vegetable-oil-allergy-card-download/ / / E P I S O D E   S P ON S O R S  Wild Pastures: $20 OFF per Box for Life + Free Shipping for Life + $15 OFF your 1st Box! https://wildpastures.com/promos/save-20-for-life-lf?oid=6&affid=132&source_id=podcast&sub1=ad BonCharge: Blue light Blocking Glasses, Red Light Therapy, Sauna Blankets & More. Visit https://boncharge.com/pages/ketokamp and use the coupon code KETOKAMP for 15% off your order.  Text me the words "Podcast" +1 (786) 364-5002 to be added to my contacts list. [12:06] What is the Red Blood Cells' Function and importance to your body? ·    Red blood cells contain hemoglobin, a combination of heme and globin, comprising cholesterol, protein, and iron. ·    Red blood cells only have one major function, it's to carry hemoglobin throughout the body. ·    Hemoglobin then, in turn, carries oxygen around and delivers it to various parts of the human body. ·    An important part of the lungs in your body's oxygen exchange are the alveoli. They facilitate the exchange of the air you breathe in and out, oxygen and carbon dioxide, with the red blood cells, which transport it throughout the body. ·    Predicting diseases will be made clear through observing these blood cells and them having an “enemy.” Glucose controls when and where blood circulation goes. ·    The problem comes when that glucose molecule sticks to the hemoglobin, leaving no space for more oxygen to get carried by the RBC. This is called glycation.  [23:53] Does Blood Donation Really Help with Diabetes? ·    Donating blood doesn't help your chances of having a chronic illness. It's more complicated than that. ·    Donating your blood decreases your hemoglobin and hematocrit quickly. That will signal your bone marrow to release red blood cells even though they're not ready to be released. ·    Ultimately, it's a short-term solution to a long-time problem. You aren't actually going to change anything permanently; everything will just go right back to where it was. ·    Solving symptoms is fine, but you must eliminate the problem's main root. Usually, these are just the result of a problem with high blood glucose levels.  [41:54] Is your blood sugar higher in the morning? Here's what you can do ·    We live in a world where processed food is easy. It's easier to prepare and eat and has a long shelf life. ·    The less processed food you get, the better it is for you. ·    Having a long eating window will also cause problems for you. It's caused by feeling full because of all the sugars floating around your body. You must eat food with high fat and protein to alleviate this concern. ·    The worst thing you can do is to eat late at night, especially past 7 P.M. Your body's ability to process sugars isn't as functional as it is during the day, causing the food you eat to be kept as sugar more. ·    The way to fix morning sugars is to remove the last meal you ate the day before. If you have a habit of skipping breakfast and having lunch and dinner, it's better to get breakfast and lunch and then skip dinner entirely. Resources from this episode: ●  Dr. Boz's Website: https://bozmd.com/ ●  Follow Dr. Boz ○  Facebook: https://www.facebook.com/Dr.AnnetteBosworth ○  Instagram: https://www.instagram.com/drboz_annettebosworthmd ○  YouTube:  https://www.youtube.com/user/annettebosworthmd ○  LinkedIn:  https://www.linkedin.com/in/annettebosworth Purchase Dr Boz's books here: https://amzn.to/3Wv9s0h ●  Join the Keto Kamp Academy: https://ketokampacademy.com/7-day-trial-a Watch Keto Kamp on YouTube: https://www.youtube.com/channel/UCUh_MOM621MvpW_HLtfkLyQ Order Keto Flex: http://www.ketoflexbook.com -------------------------------------------------------- Download your FREE Vegetable Oil Allergy Card here: https://onlineoffer.lpages.co/vegetable-oil-allergy-card-download/ / / E P I S O D E   S P ON S O R S  Wild Pastures: $20 OFF per Box for Life + Free Shipping for Life + $15 OFF your 1st Box! https://wildpastures.com/promos/save-20-for-life-lf?oid=6&affid=132&source_id=podcast&sub1=ad BonCharge: Blue light Blocking Glasses, Red Light Therapy, Sauna Blankets & More. Visit https://boncharge.com/pages/ketokamp and use the coupon code KETOKAMP for 15% off your order.  Text me the words "Podcast" +1 (786) 364-5002 to be added to my contacts list. Some links are affiliate links  // F O L L O W ▸ instagram | @thebenazadi | http://bit.ly/2B1NXKW ▸ facebook | /thebenazadi | http://bit.ly/2BVvvW6 ▸ twitter | @thebenazadi http://bit.ly/2USE0so ▸ tiktok | @thebenazadi https://www.tiktok.com/@thebenazadi Disclaimer: This podcast is for information purposes only. Statements and views expressed on this podcast are not medical advice. This podcast including Ben Azadi disclaim responsibility from any possible adverse effects from the use of information contained herein. Opinions of guests are their own, and this podcast does not accept responsibility of statements made by guests. This podcast does not make any representations or warranties about guests qualifications or credibility. Individuals on this podcast may have a direct or non-direct interest in products or services referred to herein. If you think you have a medical problem, consult a licensed physician.

Contraindications for use of intraoperative autologous red blood cell salvage by AORNJournal

Indications for use of intraoperative autologous red blood cell salvage by AORNJournal

Today, I am blessed to have Dr Robert Kiltz with me. Dr Kiltz is the Founder and Director of Central New York's first successful IVF center. He is an American Board of Obstetrics and Gynecology Diplomate, as well as Fellowship trained and Board Certified in Reproductive Endocrinology and Infertility.  Dr Kiltz specializes in advanced reproductive technology, laparoscopic and minimally invasive surgery, gynecology, endometriosis, and recurrent pregnancy loss. He advises and consults with clients from all over the world on reproductive health and fertility issues. He is known for accepting the most difficult IVF cases that other doctors/centers turn down. He specializes in Reproductive Immunology in treating recurrent pregnancy loss, unexplained infertility, and failed IVF attempts.  In this episode, Dr Robert Kiltz compares the human body to automobiles and discusses fats. Dr Robert Kiltz discusses sugar studies as well as fertility issues. Tune in as we discuss the best ways to care for your body, diets, glycans and sugars, and fertility. Register your FREE spot for the next 7 day keto kickstart challenge with Dr Jason Fung, Dr Ken Berry, Dr Annette Boz and many others: http://www.ketokampchallenge.com  Download your FREE Vegetable Oil Allergy Card here: https://onlineoffer.lpages.co/vegetable-oil-allergy-card-download/ / / E P I S O D E   S P ON S O R S  Wild Pastures: $20 OFF per Box for Life + Free Shipping for Life + $15 OFF your 1st Box! https://wildpastures.com/promos/save-20-for-life-lf?oid=6&affid=132&source_id=podcast&sub1=ad BonCharge: Blue light Blocking Glasses, Red Light Therapy, Sauna Blankets & More. Visit https://boncharge.com/pages/ketokamp and use the coupon code KETOKAMP for 15% off your order.  Text me the words "Podcast" +1 (786) 364-5002 to be added to my contacts list.   [08:56] TEDx Talk: Treat Your Body Like A Ferrari The human body should be treated with extreme care; health care and medicines increase people's longevity but not their quality of life. People require symbols that will connect them to something. Nowadays, people treat themselves more like an amusement park or a Yugo than a temple, equating to a holy body or a Ferrari.  [15:00 The Cell Membrane LOVES Healthy Fats If a person is taught something from birth, their brain will remember it as true. As research into plant oils and sugar continues, the old scientific belief that plant oils are better than sugar because they lower cholesterol and make you healthier is disproven. Ketosis entails eating plants less frequently, which aids in the elimination of excess fat and the reduction of inflation.  [22:21] Symptoms Are A Gift From Your Innate Intelligence Some diets, such as Ketosis, can be compared to addictions because there are withdrawal symptoms, and people sometimes feel better when they follow a specific diet.  People are unique, and not everyone's body and diet requirements are the same; figure out what works best for you. Nothing is the leading symptom of everything; this is true because a single symptom can appear on multiple diseases.  [34:36] Understanding The Importance of Glycans in Red Blood Cells  Glycans in red blood cells determine a person's blood type. People with different blood types are more susceptible to different antigens and glycans. Skin and blood tests can help identify what a person allergic to certain glycans should avoid.   [42:31] Fertility Issues: What You Need to Know About and How Can You Prevent It Diseases that could potentially harm people are becoming more common as a result of the various toxins that are introduced to us in our daily routine, which affect different parts of our body and also affects a child before it is born. To reduce your exposure to harmful toxins, it is critical to understand the components of everything you consume. AND MUCH MORE! Resources from this episode:  Follow Dr Robert Kiltz https://www.doctorkiltz.com/about/ Facebook: https://www.facebook.com/doctorkiltz YouTube: https://www.youtube.com/user/DrRobLive Instagram: https://www.instagram.com/doctorkiltz/ Join the Keto Kamp Academy: https://ketokampacademy.com/7-day-trial-a Watch Keto Kamp on YouTube: https://www.youtube.com/channel/UCUh_MOM621MvpW_HLtfkLyQ Register your FREE spot for the next 7 day keto kickstart challenge with Dr Jason Fung, Dr Ken Berry, Dr Annette Boz and many others: http://www.ketokampchallenge.com  Download your FREE Vegetable Oil Allergy Card here: https://onlineoffer.lpages.co/vegetable-oil-allergy-card-download/ / / E P I S O D E   S P ON S O R S  Wild Pastures: $20 OFF per Box for Life + Free Shipping for Life + $15 OFF your 1st Box! https://wildpastures.com/promos/save-20-for-life-lf?oid=6&affid=132&source_id=podcast&sub1=ad BonCharge: Blue light Blocking Glasses, Red Light Therapy, Sauna Blankets & More. Visit https://boncharge.com/pages/ketokamp and use the coupon code KETOKAMP for 15% off your order.  Text me the words "Podcast" +1 (786) 364-5002 to be added to my contacts list.   *Some Links Are Affiliates* // F O L L O W ▸ instagram | @thebenazadi | http://bit.ly/2B1NXKW ▸ facebook | /thebenazadi | http://bit.ly/2BVvvW6 ▸ twitter | @thebenazadi http://bit.ly/2USE0so ▸ tiktok | @thebenazadi https://www.tiktok.com/@thebenazadi Disclaimer: This podcast is for information purposes only. Statements and views expressed on this podcast are not medical advice. This podcast including Ben Azadi disclaim responsibility from any possible adverse effects from the use of information contained herein. Opinions of guests are their own, and this podcast does not accept responsibility of statements made by guests. This podcast does not make any representations or warranties about guests qualifications or credibility. Individuals on this podcast may have a direct or non-direct interest in products or services referred to herein. If you think you have a medical problem, consult a licensed physician.

Get a free nursing lab values cheat sheet at NURSING.com/63labs   What is the Lab Name for Red Blood Cell (RBC) Lab Values? Red Blood Cell   What is the Lab Abbreviation for Red Blood Cell? RBC   What is Red Blood Cell in terms of Nursing Labs? Red Blood Cells (RBCs) contain hemoglobin which is responsible for oxygen transport throughout the body. RBCs are primarily produced in the bone marrow, they have a life span of 120 days and are destroyed in the spleen and liver. RBC production is regulated by erythropoietin (EPO) which is produced and released from the kidneys.   What is the Normal Range for Red Blood Cell? Male: 4.5 – 5.5 x106/cells/mm3 Female: 4.0 – 4.9 x106/cells/mm3   What are the Indications for Red Blood Cell? Identify: Anemia Blood loss   What would cause Increased Levels of Red Blood Cell? Dehydration Polycythemia Vera Chronic Obstructive Pulmonary Disease (COPD) High altitude Congenital heart disease CorPulmonale Pulmonary fibrosis Thalassemia trait   What would cause Decreased Levels of Red Blood Cell? Chemotherapy Anemia Hemorrhage Hemolysis Hemoglobinopathy Advanced cancer Leukemia Lymphoma Pernicious anemia Rheumatoid disease Organ failure Bone marrow failure Hypervolemia Pregnancy

In this podcast, JPEN Editor-in-Chief Dr. Kenneth Christopher, interviews Dr. Kara Calkins, neonatologist and clinical scientist from the David Geffen School of Medicine, Department of Pediatrics, Division of Neonatology at the University of California, Los Angeles, and senior author of “A Multi-Oil Intravenous Lipid Emulsion with Fish Oil, Clinical Outcomes and Red Blood Cell membrane, Polyunsaturated Fatty Acids in Extremely Low Birth Weight infants” published in the March 2023 issue of JPEN. Business Corporate by Alex Menco | alexmenco.net Music promoted by www.free-stock-music.com Creative Commons Attribution 3.0 Unported License creativecommons.org/licenses/by/3.0/deed.en_US March 2023

PRBC's or packed red blood cells are one of the most common blood products administered in critical care. The following episode covers the importance of red blood cells, understanding hemoglobin and hematocrit levels, how lab levels are attained, some of the common reasons to transfuse, transfusion basics, and the critical transfusion associated complications. 

The Nerve System “talks” with the whole body through routes of communication other than a direct nerve impulse.

$5 Q-BANK: https://www.patreon.com/highyieldfamilymedicine Intro 0:30, Sickle cell anemia 1:34, Thalassemia 9:03, Hereditary spherocytosis 15:36, G6PD deficiency 17:38, Pyruvate kinase deficiency 19:27, Microangiopathic hemolytic anemia 20:08, Autoimmune hemolytic anemia 24:56, Paroxysmal nocturnal hemoglobinuria 26:59, Blood transfusion reactions 28:31, Drug-induced hemolysis 30:05, Malaria 30:42, Babesiosis 31:47, Iron deficiency anemia 32:34, Megaloblastic anemia 35:34, Lead poisoning 37:59, Porphyria 39:07, Sideroblastic anemia 40:01, Aplastic anemia 41:23, Polycythemia 45:24, Methemoglobinemia 46:34, Carbon monoxide poisoning 47:56, Hemophagocytic lymphohistiocytosis 48:48, Practice questions 49:34

In this week's Circulation on the Run podcast, we turn the show over to Circulation's Social Media Editors Dr. Pishoy Gouda and Dr. Peder Myhre. They interview the 2022 recipients of the Joseph Loscalzo Award for Best Basic Science Article, and the 2022 recipients of the James T. Willerson Award for Best Clinical Article. Dr. Maryjane Farr: Welcome everybody to Circulation on the Run. My name is Maryjane Farr, and I'm the digital strategies editor at Circulation. Carolyn and Greg are on break this week. And as part of the Circulation tradition, we turn the stage over to two of our social media editors, Dr. Peder Myhre from Oslo and Dr. Pishoy Gouda from Edmonton. They're going to be interviewing the 2022 winners of the Loscalzo Award and the Willerson Award. Take it away, Peter and Pishoy. Dr. Peder Myhre: Today. Pishoy, we have a very exciting issue of Circulation on the Run. We are going- Dr. Pishoy Gouda: We certainly do. Dr. Peder Myhre: Yeah. We're going to discuss two amazing papers that are award-winning and we're going to talk to the first authors who really know these papers and conducted the amazing work that we're going to display here today. Dr. Pishoy Gouda: Yeah, I'm excited. Peter. And with us today, we'll start talking about the recipients of the Loscalzo Award. So I wanted to start off by introducing Dr. Leo and Dr. Suvorava, who are the very proud recipients of the Loscalzo Award for their paper entitled Red Blood Cell and Endothelial eNOS Independently Regulate Circulating Nitric Oxide Metabolites and Blood Pressure. So welcome Doctors Leo and Suvorava. How are you guys doing today? Dr. Francesca Leo: Hi, thank you for the introduction and pretty well, I'm currently in Italy for my winter Christmas holidays, but I'm really excited and happy to be here today with you. Dr. Pishoy Gouda: Excellent. Dr. Suvorava: Hello. I'm also very happy to be here today. Thank you for your invitation and for your congratulations. It's a privilege and honor for me to be a recipient of this Dr. Loscalzo Award. Thank you. Dr. Pishoy Gouda: Well, I just wanted to start off by taking another second here to congratulate you both on this award. We all know the sheer amount of work and dedications to get these projects going, so congratulations. And I'm going to start off with a really easy question for you guys. When you found out that you were a recipient of the Loscalzo Award, who is the first person that you told? Dr. Francesca Leo: As I mentioned, I'm Italian and as a good Italian I need to say that. Of course, the first people I told were my parents because we all know that Italian and parents are just one thing. So they were the first ones. And then all of course, my partner and friends came second, parents first, family first. Dr. Pishoy Gouda: Very good. What about yourself, Tatsiana? Dr. Tatsiana Suvorava: Hi. Yeah. I had to think back like seven years ago and I very good remember one day when I was really excited about the results, what we found, I was in the lab, I was developing a western blood to check the functional ability of our models and it showed that it was very successful that we couldn't knock out our protein of interest almost completely. And at that day exactly, we had a lab meeting. So I directly pulled this image on my USB stick and then showed it on the lab meeting. So actually these were my colleagues who first hear about this. Dr. Pishoy Gouda: That's awesome. That's lovely. Well, after I got married, sometimes my parents get bumped to the second phone call and they weren't very happy about that and they let me know very clearly. But let's switch gears a little bit and tell us a little bit about how you made the decision to pursue academics. It's such a daunting career and a daunting topic sometimes. And how did you get interested in research and how did you find yourself coming into this research project? Dr. Francesca Leo: If I can start first. Well, I decided to pursue an academical career at the beginning following my master thesis that I did at the University of Pisa here. And I've always wanted to go abroad and gain experience, get to know different realities apart from Italy. And I was actually really lucky that I got the opportunity to work in the laboratory Professor Cortese-Krott because that gave me the opportunity to grow a lot, both personally and professionally, of course. I learned new techniques and together with our great team, we managed to achieve many goals. In particular, this paper, I must say that was my last satisfaction before my doctoral exam. So I think the feeling that you get after any also small achievement is something that you can really, I cannot find it hard to explain to people that are not in research or not in science in general. Dr. Pishoy Gouda: No, I totally agree. When I get a new data set, I get so excited and my wife is telling me, what are you doing is I just got new data and I'm like a little child on Christmas day. She doesn't understand it, but she appreciates that some people like that. What about yourself? What about yourself? Dr. Tatsiana Suvorava: Yeah, well my decision to pursue academic career started with as probably for many researchers, started from intense fascination from one discovery. I was at the beginning of my bachelors' science studies and then the Nobel Prize was given for the discovery of nitric oxide as a signaling molecule in a cardiovascular system. And I was so fascinated that the gaseous molecule so simple has so lots of responsibility in the body. And since that time, that was always in the focus of my research and this is for me, a lifelong journey. I'm still on the way. Dr. Pishoy Gouda: That's amazing, Tatsiana. And that sort of sets us up nicely. And as you guys know, I'm a interventional cardiologist. Basic science is a little bit farther from my memory. So I'll start off by admitting that my basic science research is not where it should be. But with that in mind, I was wondering if you could just tell our listeners a little bit about your research and why this question is so important and explain it to you like you were lowly clinicians that don't really understand basic science. Dr. Francesca Leo: I always take over Tanya, but yes, I have less to say than you. I must admit. Dr. Tatsiana Suvorava: Okay so let's start. No problem. Dr. Pishoy Gouda: It's a team effort. It's a team effort. Dr. Tatsiana Suvorava: Its a team effort and yeah. Ok. Dr. Francesca Leo: It's been a really teamwork, I must say from the really, really, really beginning. So this paper was, as I said, the central focus of my doctoral thesis. I just take two small part of it, of course, in particular, what is really important on the paper, I think that is we use really new mice models that Tanya and my Professor Cortese-Krott really and highly characterized at the really beginning, so developed completely from new, and they are mice that are expressing or not eNOS this protein that is responsible for nitric oxide production in the endothelium or in red blood cells. So the importance of this research was to demonstrate the role or pivotal role of eNOS expressed in the red blood cells in the modulation of blood pressure as well as circulating nitric oxide metabolites. And we actually did it with this paper. And considering that cardiovascular disease are one of the major causes of death nowadays, this results can really have important clinical and therapeutical implications for future research and real life, let's say. Dr. Tatsiana Suvorava: Yeah, maybe I could add to Francesca. Dr. Francesca Leo: Sure, Dr. Tatsiana Suvorava: Yeah. Dr. Pishoy Gouda: Of course. Dr. Tatsiana Suvorava: I think our research was especially important because it's identified the existence of previously unrecognized and actually non-canonical pathway, how the red blood cells can regulate blood pressure. And it was so exciting about this. Dr. Pishoy Gouda: Right. So trying to find out if the red blood cell, nitric oxide synthase can actually regulate blood pressure. And this has obviously lots of clinical implications. So in practice, how did you guys set up your experiments? How did you try to test the significance of the Enos red blood cells effects? Dr. Francesca Leo: Just if I can add something, what was really important. So what is known is that Enos expressing the endothelium plays an important role in the modulation of blood pressure. What we actually found out is that the one in the red blood cells also is involved and played a role that seems to be independent from the one played from the eNOS expressed in the endothelium. For answering your question, I also, I need to say I'm not the right candidate because this is a huge project that started about 10 years ago. So I was really, I repeated and I will always repeat it, I was really lucky to take part to this project and to get the opportunity to take part to this journey because it was really a journey and it gave me the opportunity to work with very different people and get in touch with very different realities, academical realities. And I can say that this project started from my previous boss and Tanya that they had this idea and started this whole project together with, of course Tanya is the one that is involved since the really beginning. So she can definitely better answer to this question. Dr. Tatsiana Suvorava: Yeah, thank you, Francesca. It's a long way actually what we did, and actually I started this particular project on the level of postdoc and eNOS and hypertension have been already in a center of my research interest for several years. And in a previous project what I had, I also had a transgenic mice, which were generated by conventional genetic approach by micro injection of D N a. And at that time we observed a significant contribution of external endothelial component into the blood pressure regulated. However, at that time we were not able to identify the exact extracellular allocation of this component. There were several candidates which were suggested, and one of them there were red blood cells. And everyone was kind of skeptical about this because the level of eNOS protein in red blood cells is extremely low. And furthermore, there were a lot of doubts how eNOS activity can be exported from the red blood cells because it's red blood cells are full of heme, which is a scavenger of nitric oxide. Furthermore, actually it was not clear how they transported and how it is released this activity. But now if we think that red blood cells are the largest component contributor to overall cell number in the body, so maybe then we can more critically think and then think that the total amount of red blood cells maybe compensate for this very low eNOS protein expression. And actually because they have a high density and their shape is erase high, so they provide a very sufficient release of this inactivity from red blood cells. But this idea was doubted for many years, although there it was reported that eNOS is expressed in red blood cells in 2006 was a paper. Dr. Pishoy Gouda: Well that's very exciting. So what we really learned is that eNOS system in both red blood cells and endothelial cells contribute to blood pressure regulation. Now I might direct this to you, Francesca. Well what does that mean for the clinicians in our audience? Well, what does that mean for a hypertension patients? Dr. Francesca Leo: So for clinicians, so, I must say these findings may have really important pathophysiological implication in the understanding of the interrelationships between hematologic and cardiovascular disease and may reveal the really novel therapeutic approaches to improve tissue perfusion. Moreover, our data and models may also help in understanding how red blood cells eNOS signaling can really affect red blood cells function, the scavenging of nitric oxide, as Tanya had previously said, as well as the crosstalk between nitric oxide and the sulfides that are of highly present in the bloodstream and in the body as well as oxygen transport. And may also enable us to refine the criteria for blood banking transfusion and to also try to develop new strategies or therapies for many diseases and pathologies where red blood cells are involved. For example, coronary artery disease, chronic kidney disease that normally are pathologists that show a decrease in the expression of eNOS expressed in the red blood cells or hematologic disease hemoglobinopathies, which are normally characterized by a systemic decrease in nitric oxide bioavailability or one of the most common diseases, sickle cell disease. Cause of course the shape of red blood cells is definitely also responsible of their functioning. And it can also determine, of course, an impairment or more alteration in the release of nitric oxide in the body. Dr. Tatsiana Suvorava: Yeah, maybe I'll just add few words. So actually that's open as a perspective that impairment of red blood cells, eNOS may contribute to the pathogenesis of hypertension. So this is the most important thing I think here in clinician point of view. Dr. Pishoy Gouda: Yeah, absolutely. Lots of different ways that this research might be heading. And like you were saying earlier, Tatiana research is really a longitudinal process. You started this almost a decade ago and I'm sure that there's more projects and plans that you have with this for the future. What are you working on now? Dr. Tatsiana Suvorava: Well, I'm still in academia and I'm still doing academic career, actually. We continued our study and we also studied pathophysiological significance of red blood cells eNOS for cardio protection. For example, in regulation of coronary blood flow, myocardial performance in myocardial infarction, acute myocardial infarction in vivo. We recently published this and here we could also see involvement of red blood cells eNOS, which limit infarct size in acute myocardial infarction. In a pipeline is also a manuscript about red blood cells and endothelial cells eNOS in exercise induced cardio protection and of course the other focus would be the role of red blood cells eNOS in other disease conditions and a chronicle kidney disease for example. It will be also investigated. So we are full of plans, however, I changed department, but I'm still having eNOS in focus and hypertension as well. Dr. Pishoy Gouda: Well that's really exciting stuff and yes, I just wanted to congratulate you both again Dr. Leo and Suvorava and thank you for taking the time to share with us your very clear passion for this topic and I wish you guys both the best of luck. Congratulations again. Dr. Francesca Leo: Thank you so much. Dr. Tatsiana Suvorava: Thank you so much. Dr. Pishoy Gouda: Well congratulations again to our award recipients and Peter, why don't you tell us a little bit about what article we're going to be talking about next? Dr. Peder Myhre: Yes, thank you so much Pishoy. And first, I must say it was so much fun to listen to you guys discuss the paper. You can really feel the passion for the science coming through the microphone. And that was for me as a clinician as well. I learned a lot. And now we're going to actually take a step and move over back to clinical science and we are going to talk to the winners of the James T. Willerson Award. So welcome doctors, Jeanne du Fey and Dr. Alexandra Prepoudis. Dr. Jeanna du Fay de Lavallaz: Thank you very much for having us on the podcast. It's a pleasure to be here and we're also very happy to be able to discuss this paper with you. And of course we were extremely glad to receive this award, so we're excited about the discussion. Dr. Peder Myhre: And so for the listeners who are not familiar with the Willerson Award, this award recognizes the best clinical paper published in circulation in the preceding 12 months. And this award honors Dr. Willerson, who was a major leader within American Heart Association. And among his roles, he served for over a decade as the editor-in-chief of circulation. And during his tenure, the journal transitioned away from a once monthly format, vastly expanded its international footprints and rose substantially in stature and impact. And speaking of international footprint, today we have authors from all over the world and I know both of you, Jeanne and Alexandra are from the amazing biomarker group in Basel led by Christian Mueller. So Alexandra, if we can start with you, I just want to learn a little bit more about you. Where do you work, where are you in your career and your areas of interest? Dr. Alexandra Prepoudis: Good evening and thank you for the introduction. My name is Alexandra Prepoudis and I'm currently a cardiology fellow at the University Hospital of Basel in Switzerland. I have always been very interested in clinical research, so I decided to join the group of Professor Christian Mueller in Basel for a year prior my residency in internal medicine. And that's how I met Jeanne and the whole study team. Dr. Peder Myhre: Very nice. And Jeanne, what about you? Dr. Jeanna du Fay de Lavallaz: So my name is Jeanne du Fey and I'm currently also a cardiology fellow at the hospital in Zurich. I moved a little bit, but my main research is still based in Basel. You don't leave Professor Mueller's group once you're in it. So I sticked around. So I am undertook physician scientist track after med school and for my MD PhD I was very lucky to integrate Dr. Mueller's group into the paper we are going to discuss tonight is actually the very first study that I designed during my PhD of course with a lot of help from the whole group of Professor Mueller, professor Mueller himself and of course Alexandra who joined a little bit later and really helped us tackle quite a big piece of the biomarker research that I'm very excited to talk about. Dr. Peder Myhre: So that is amazing. So this is the first paper you designed and what a wonderful debut because today we're going to discuss this award-winning paper and it is entitled Skeletal Muscle Disorder and Non-Cardiac Source of Cardiac Troponin T. And of course we are within the field of troponin and I must admit Jeanne and Alexandra that I myself is a troponin nerd myself. I love research and learning more about troponin and for me this paper was really something I was eager to learn more about because we've all been questioning what is the impact of skeletal muscle disease on troponin. So perhaps Jeanne, if you could start to explain the background for this study, and what was the research question? Dr. Jeanna du Fay de Lavallaz: So in the past years, I think there were quite a few reports. These were mostly case series of what you have just mentioned. So it's this observation that skeletal muscle disease might actually have an impact on some troponin measurements and we were not exactly sure which. So there are these two main isophones of troponin, the troponin T and the troponin I. Depending on the hospital, depending on the country, one of both might be measured either the troponin I or the troponin T. And then for troponin T we have only one essay and then for troponin I there are several of them. So there is kind of a big mix up there of what is possibly obtainable to assess cardiovascular health and basically also more coronary health, well cardiovascular health in patients that we see every day in the clinic. And well, as you just mentioned, we had noticed in the past that sometimes it's troponin T was behaving in weird way in patients that were also suffering of some muscle skeletal muscle disease. So Prof. Mueller is leading a very large group biomarkers on troponin research and this is something that we decide to tackle in a very structured way in order to be able to rehab an answer and bring something to the field that might be maybe a little bit more consistent than this, however very interesting case series, but that were maybe a little bit done on very specific disease and a little bit all over the place. Dr. Peder Myhre: Exactly, and this is exactly what really made this paper so amazing is that first of all, you structured the clinical part of it with a prospective cohort. You did multiple essays on the patients and you even included some translational work on top of that, which is truly amazing. So I was wondering, Alexandra, if you perhaps could start with explaining the clinical part of the study, the patient cohort, the mythology use, et cetera. So please, Alexandra. Dr. Alexandra Prepoudis: We enrolled patients with muscle complaints. So for example, muscle pain, weakness, stiffness or fasciculations. And we enrolled them at four sites in two countries, most of them during ambulatory visits. And from each patient we collected a blood sample and we measured four different high sensitivity cardiac troponin assays. So one for troponin T and three for troponin I. Then patients underwent the cardiac workup including E C T, echo cardiography and cardiac M R I depending on the clinical indication. As a control group, we used patients from a prior study where patients who presented to the emergency department with the leading symptom of chest pain were enrolled. So of these we analyzed patients without skeletal muscle disease in whom a cardiac cause of chest pain could be excluded. Dr. Peder Myhre: Great. So really a big and well pheno typed group of patients. And before we go to the results, we're going to also learn a little bit about the experimental part of the study that you conducted. So Jeanne, if you would just explain what was, this was something with the gene expression in the muscles, right. Dr. Jeanna du Fay de Lavallaz: So we decided to be a little bit original and to bring it back to the bench instead of bringing it to the bedside as we usually do. And- Dr. Peder Myhre: I love it. Dr. Jeanna du Fay de Lavallaz: We will soon. We were also very lucky to have amazing collaborators because that allowed us to collaborate with a rheumatologist with neurologists. And these doctors might have in the past collected some muscle tissue for completely different muscle analysis. So in order to phenotype the diseases that the patients were actually suffering of and we're also lucky enough so that there was sometimes some of this muscle tissue is still available and we basically extracted mRNA from these skeletal muscle samples. And what we looked at was the mRNA of the different troponin genes that we could find in there. So as you probably know, there is some genes coding for skeletal troponin and there are some genes coding for cardiac troponin. And what we could see that was, we might come to that in the results, but basically our goal was to look at the expression of the different skeletal or cardiac troponin in these skeletal muscle samples. Dr. Peder Myhre: Exactly. And the next question is going to be difficult because I want you to summarize the findings and there are so many findings to supplement. This is really, it's like pressure. But please Alexandra, can you try to summarize the primary results of this paper? Dr. Alexandra Prepoudis: Yes, of course. I will try my best. So maybe first about half of the cohort showed the cardiac disease IE the coronary heart disease, atrial fibrillation, or chronic heart failure. So cardiomyocyte injury resulting from cardiac disease was a major contributor to elevated troponin T and I concentrations even in these patients with skeletal muscle disorders. But troponin T concentrations were above the upper limit of normal in about 55% and the concentrations were significantly higher compared with control subs checked. While troponin I concentrations were elevated to a significantly lower percentage, which were also comparable to the concentrations in the control group. Also, we found that the elevated troponin T concentrations were restricted largely to patients with non-inflammatory myosis and myositis. And maybe one thing to the gene expression regarding the gene expression analysis, we found the eightfold up regulation for the gene and coding for cardiac troponin T in skeletal muscle compared with controls without skeletal muscle disease. Dr. Peder Myhre: Wow, that is so great. So please let me try to summarize these important findings to the listeners. So you actually found in patients with skeletal muscle disease, a much higher level of troponin T compared to healthy controls or at least controls without myocardial infarction. And for troponin, these differences were not that pronounced. So that means gene, that troponin T in patients with certain types of skeletal muscle disease may be falsely positive. Is that correct? And how would you put these findings in relation to previous studies in the field and also perhaps some clinical implications of the findings? Dr. Jeanna du Fay de Lavallaz: So yeah, I think we can say that in the patient where that was the case, this is actually falsely positive because when we talk about cardiac troponin T, cardiac troponin, we expect it coming from the heart, certainly not from the muscle of the patients or at least it's what cardiologists have been trying to not diagnose in the past years by refining also the assays that we were using so that it doesn't cross-react with anything coming from a skeletal muscle. And I think regarding previous studies in the field, so we tackled, I believe several aspect with this paper that hadn't really been well investigated before. And our study design helped with that a lot. So first we included patients based on their complaints that was not a specific cohort with a certain type of disease. We really enrolled them if they presented with some muscle complaints, so not a specific already diagnosed disease. So this was the first point. And then second also, we investigated several troponin I assays, which also allowed us to have a broader observation of how this assay are actually interacting also with each other or how they relate to this troponin T assay, which is the only one existing. And then finally, I think this translational part with the MRN analysis really helped us to go back to the primary hypothesis, how does that work? Why is this the case at all? And finding this re-expression of the cardiac troponin T in the skeletal muscle really tells us that this might actually not be a problem with the assay itself but might really be that we have some cardiac troponin T circling in the blood and being measured by a perfectly well working assay, which is a totally different mechanism than for instance, cross reaction that we might sometimes observe for instance, with troponin I assays. Dr. Peder Myhre: Exactly. And the findings were so consistent across the 3 troponin I assays and supported by the biopsy findings, I think they were so robust. And you know, we're talking about how this might impact adjudication of a suspected myocardial infarction, but also troponin is a very strong prognostic marker within chronic conditions and in ambulatory patients. And even there it may really impact the utility of troponin as a risk marker. Alexandra, don't you think so? Dr. Alexandra Prepoudis: So, to come back to the first part of your question, what about patients with myocardial infarction? Our study did not directly investigate the impact of these unexpected troponin T concentrations on the diagnosis of myocardial infarction. But we believe that it's reasonable to say that if patients with a known chronic skeletal muscle disease present with chest pain to for example the emergency department and the first troponin T comes back elevated, the clinician should be aware that the skeletal muscle can be a possible source of this biomarker. So if possible, a troponin I should be obtained in these patients. Dr. Peder Myhre: Excellent. And that brings us to the last question of today, I think Jeanne, and that is the future direction of this field. We now know, I think for certain that some skeletal muscle disease have an elevated cardiac troponin T, or perhaps not cardiac, but at least troponin T. So what do we need to learn more about this? And is there any way we can improve the assays? Please, Jeanne, let me know your thoughts about the future. Dr. Jeanna du Fay de Lavallaz: So that's a complex question. I think already we are kind of running into troubles when we already just see the current situation with these assays. Depending on the countries, depending on the hospitals, depending on the laboratory background that all the laboratory measurement system that we might have. Some hospitals have a total different approach on which troponin to measure and what's troponin to make available for their physicians. But I think these biomarkers haven't finished to surprise us and also most likely to bring us some very good prognostic tools. And I believe once we can really refine the exact origin of which elevation in which patient and what this does imply for their prognosis, we might also be able to just predict much better where with our patients are going, what kind of diagnostic or treatments that we need to use in order to improve their life on the short and long term. So I have quite a lot of hope for these different assays to be better understood in the coming years. Dr. Peder Myhre: What a wonderful way to finalize this podcast. Jeanne and Alexandra, thank you so much for participating and for sharing your knowledge in the field and to learn about your current situation with work and your choices of career. And also a big thank you to Francesca and Tanya for the winners of the LOSCALZO Award for sharing their research. So on behalf of Pishoy and myself, I want to thank everyone for listening and thank you to the amazing authors and winners of the awards. This is Peter Myra, and on behalf of myself and Pishoy Gouda, we thank you for listening. Dr. Greg Hundley: This program is copyright of the American Heart Association 2022. The opinions expressed by speakers in this podcast are their own and not necessarily those of the editors or of the American Heart Association. For more, please visit ahajournals.org.

This episode is also available as a blog post: https://thecitylife.org/2022/12/23/glassfrogs-achieve-transparency-by-packing-red-blood-cells-into-mirror-coated-liver/ --- Send in a voice message: https://anchor.fm/citylifeorg/message Support this podcast: https://anchor.fm/citylifeorg/support

Energetic Health Radio with Dr. Henry Ealy – Dr. H  discusses what Live Blood Cell Analysis reveals about Red Blood Cell aggregation and how the spike protein and glycosylation are the likely causes. Also, in this episode, Dr. H provides some real talk about the elephants in the room in the health freedom movement. From unnecessary drama to selfish...

Energetic Health Radio with Dr. Henry Ealy – Dr. H  discusses what Live Blood Cell Analysis reveals about Red Blood Cell aggregation and how the spike protein and glycosylation are the likely causes. Also, in this episode, Dr. H provides some real talk about the elephants in the room in the health freedom movement. From unnecessary drama to selfish...

Guest: Dr Karin van den Berg heads up the Clinical Services for the Eastern Cape division of SANBS, providing clinical oversight for all blood transfusion related activities.See omnystudio.com/listener for privacy information.

CME credits: 0.25 Valid until: 27-10-2023 Claim your CME credit at https://reachmd.com/programs/cme/targeting-the-fc-receptor-pathway-to-treat-red-blood-cell-alloimmunization/13908/ Program Chairman: Roberto Romero, MD, DMedSci Chief, Perinatology Research Branch Division of Maternal-Fetal Medicine and Obstetrics Division of Intramural Research NICHD/NIH/DHHS Editor-in-Chief for Obstetrics The American Journal of Obstetrics and Gynecology How well do you understand the biology of hemolytic disease of the fetus and newborn (HDFN)? What about its connection to the FcRn receptor pathway and IgG? Drs. Lee Shulman and Ken Moise go beyond the basics taught in medical school immunology and look more closely at FcRn's role in protecting IgG. With an improved understanding of these mechanisms, we can expand therapeutic targets beyond the fetus and newborn and finally put the needles away.

This interesting form of training may help boost your red blood cell production. Dr. Berg's Keto and IF Lab: https://www.facebook.com/groups/drbergslab/ How to Bulletproof your Immune System FREE Course: https://bit.ly/39Ry3s2 FREE MINI-COURSE ➜ ➜ Take Dr. Berg's Free Keto Mini-Course! ADD YOUR SUCCESS STORY HERE: https://bit.ly/3z9TviS Find Your Body Type: https://www.drberg.com/body-type-quiz Talk to a Product Advisor to find the best product for you! Call 1-540-299-1557 with your questions about Dr. Berg's products. Product Advisors are available Monday through Friday 8 am - 6 pm and Saturday 9 am - 5 pm EST. At this time, we no longer offer Keto Consulting and our Product Advisors will only be advising on which product is best for you and advise on how to take them. Dr. Eric Berg DC Bio: Dr. Berg, 51 years of age is a chiropractor who specializes in weight loss through nutritional & natural methods. His private practice is located in Alexandria, Virginia. His clients include senior officials in the U.S. government & the Justice Department, ambassadors, medical doctors, high-level executives of prominent corporations, scientists, engineers, professors, and other clients from all walks of life. He is the author of The 7 Principles of Fat Burning. Dr. Berg's Website: http://bit.ly/37AV0fk Dr. Berg's Recipe Ideas: http://bit.ly/37FF6QR Dr. Berg's Reviews: http://bit.ly/3hkIvbb Dr. Berg's Shop: http://bit.ly/3mJcLxg Dr. Berg's Bio: http://bit.ly/3as2cfE Dr. Berg's Health Coach Training: http://bit.ly/3as2p2q Facebook: https://www.facebook.com/drericberg Messenger: https://www.messenger.com/t/drericberg Instagram: https://www.instagram.com/drericberg/ YouTube: http://bit.ly/37DXt8C Pinterest: https://www.pinterest.com/drericberg/

Host: Lee P. Shulman, MD, FACMG, FACOG Guest: Kenneth J. Moise Jr., MD Program Chairman: Roberto Romero M.D. D.Med Sci.Chief, Perinatology Research BranchDivision of Maternal-Fetal Medicine and ObstetricsDivision of Intramural ResearchNICHD/NIH/DHHSEditor-in-Chief for ObstetricsThe American Journal of Obstetrics and Gynecology Are you taking the right steps to consistently ensure all of your patients at risk of alloimmune disorders of pregnancy, specifically HDFN, receive a helping hand plus timely and appropriate clinical care? Despite having considerable clinical consequences, this area of medicine is not fully understood by many clinicians. Drs. Shulman and Moise provide expert insight on red blood cell alloimmunization, highlighting essential pathophysiology and current and evolving management strategies. Join us to learn new ways to approach this complicated and rare clinical condition.

CME credits: 0.25 Valid until: 30-09-2023 Claim your CME credit at https://reachmd.com/programs/cme/red-blood-cell-alloimmunization-pathophysiology-diagnosis-treatment-and-prevention/13907/ Program Chairman: Roberto Romero M.D. D.Med Sci.Chief, Perinatology Research BranchDivision of Maternal-Fetal Medicine and ObstetricsDivision of Intramural ResearchNICHD/NIH/DHHSEditor-in-Chief for ObstetricsThe American Journal of Obstetrics and Gynecology Are you taking the right steps to consistently ensure all of your patients at risk of alloimmune disorders of pregnancy, specifically HDFN, receive a helping hand plus timely and appropriate clinical care? Despite having considerable clinical consequences, this area of medicine is not fully understood by many clinicians. Drs. Shulman and Moise provide expert insight on red blood cell alloimmunization, highlighting essential pathophysiology and current and evolving management strategies. Join us to learn new ways to approach this complicated and rare clinical condition.

Jordan Peterson, Tucker Carlson. Deadly Environmental Policies Killing Countless Poor and Crippling Europe, U.S.  Covid Vaccines- Deformed Red Blood Cells, Blood Clots…   Tucker Carlson: Deadly Environmental Policies Crippling Europe and U.S. Covid Vaccines Deformed Red Blood Cells, Blood Clots and Elevated Blood Viscosity Jordan Peterson- The environmentalist's model will make the poor people poorer.   Tucker Carlson: Things are falling apart very quickly https://youtu.be/Zn6c-UkqlHo 2,310,126 views Aug 29, 2022 108K Fox News 9.85M subscribers Fox News host Tucker Carlson reacts to Europe moving backward over energy on 'Tucker Carlson Tonight.' #FoxNews #tucker   Tucker Carlson: This is an attack on your autonomy https://youtu.be/OIcwgiCi4WE 998,681 views Aug 30, 2022 Fox News 9.85M subscribers Fox News host Tucker Carlson voices his concerns over liberal environmental policies on 'Tucker Carlson Tonight.' #FoxNews #tucker Subscribe to Fox News! https://bit.ly/2vaBUvAS Watch more Fox News Video: http://video.foxnews.com Watch Fox News Channel Live: http://www.foxnewsgo.com/ FOX News Channel (FNC) is a 24-hour all-encompassing news service delivering breaking news as well as political and business news. The number one network in cable, FNC has been the most-watched television news channel for 18 consecutive years. According to a 2020 Brand Keys Consumer Loyalty Engagement Index report, FOX News is the top brand in the country for morning and evening news coverage. A 2019 Suffolk University poll named FOX News as the most trusted source for television news or commentary, while a 2019 Brand Keys Emotion Engagement Analysis survey found that FOX News was the most trusted cable news brand. A 2017 Gallup/Knight Foundation survey also found that among Americans who could name an objective news source, FOX News was the top-cited outlet. Owned by FOX Corporation, FNC is available in nearly 90 million homes and dominates the cable news landscape, routinely notching the top ten programs in the genre. Watch full episodes of your favorite shows The Five: http://video.foxnews.com/playlist/lon... Special Report with Bret Baier: http://video.foxnews.com/playlist/lon... Fox News Primetime: https://video.foxnews.com/playlist/on... Tucker Carlson Tonight: http://video.foxnews.com/playlist/lon... Hannity: http://video.foxnews.com/playlist/lon... The Ingraham Angle: http://video.foxnews.com/playlist/lon... Fox News @ Night: http://video.foxnews.com/playlist/lon... Follow Fox News on Facebook: https://www.facebook.com/FoxNews/ Follow Fox News on Twitter: https://twitter.com/FoxNews/ Follow Fox News on Instagram: https://www.instagram.com/foxnews/   Covid Vaccines Deformed Red Blood Cells, Blood Clots and Elevated Blood Viscosity Watch this report at- https://frankspeech.com/absolute-truth-emerald-robinson By The Absolute Truth with Emerald Robinson, 30 August, 2022   Jordan Peterson  “The environmentalist's model will make the poor people poorer. “ - Jordan Peterson 

KSQD 7-13-2022: How anesthesia alters your brain to blank out consciousness; The many roles of iron in physiology, especially in immunity, but too much is toxic; The role of red blood cells in the immune system; All about Central Serous Retinopathy; Functional Medicine Conference review: Sleeping before and after learning is beneficial; Direct current stimulation devices improve sleep and reduce depression

KSQD 6-08-2022: Novavax is a more conventional vaccine against COVID-19; The many roles of iron in physiology, especially in immunity, but too much is toxic; The role of red blood cells in the immune system; All about Central Serous Retinopathy; Functional Medicine Conference review: Sleeping before and after learning is beneficial; Direct current stimulation devices improve sleep and reduce depression

Pathologists are responsible for developing safe and efficient blood selection policies for routine and emergency bleeding situations, in a variety of clinical scenarios and in different practice settings, explains Monica Pagano, MD, FCAP, in this CAPcast interview. Dr. Pagano is Medical Director, Transfusion Service Laboratory at the University of Washington Medical Center and led the development of a Clinical Pathology Improvement Program case-based course on this topic (https://capatholo.gy/3wglhvN).

On this classic ID the Future from the vault, biologist Michael Denton reflects on paradigm shifts in science he's witnessed in his lifetime and how his own thinking has changed. He also looks at how these shifts challenge Darwinian evolution in new ways. Denton is the author of the new book The Miracle of Man: The Fine Tuning of Nature for Human Existence. Get a copy today. Source

Dr. Luca Benatti is the CEO of EryDel, a biotech company developing and commercializing cell-therapy treatments for rare diseases using autologous red blood cell encapsulation technology to deliver drugs. With a focus on the rare genetic disease Ataxia Telangiectasia (AT), Erydel has just completed a multi-center, multi-national phase III trial for the disease. Their symptomatic treatment has been shown to delay the progression of the disease and could be part of a regular immunoglobulin therapy session for these patients. Luca explains, "The first characteristic of our technology since there are similar technologies that utilize red blood cells to deliver therapeutics, is that we are the only one that has developed a technology that can work at the bedside. So, it's really the only one that can use the patient's blood, and we don't need to have a centralized lab. The beauty of this technology is that it is the only one that can use a sustained release formulations technology - that is, the one that is actually being developed for Ataxia Telangiectasia - on which we have completed phase III study results." "So, from the time of blood withdrawal from the patients and for our lead product, we take 50 milliliters of blood from the patient, a small amount, and within a couple of hours, patients can go home. They are only required to stay for the blood withdrawal and the blood infusions. The rest of the process is done by a small machine that is fully automated and operated by trained personnel." #EryDel #AtaxiaTelangiectasia #EryDex #RareDisease #AT EryDel.com Download the transcript here

Dr. Luca Benatti is the CEO of EryDel, a biotech company developing and commercializing cell-therapy treatments for rare diseases using autologous red blood cell encapsulation technology to deliver drugs. With a focus on the rare genetic disease Ataxia Telangiectasia (AT), Erydel has just completed a multi-center, multi-national phase III trial for the disease. Their symptomatic treatment has been shown to delay the progression of the disease and could be part of a regular immunoglobulin therapy session for these patients. Luca explains, "The first characteristic of our technology since there are similar technologies that utilize red blood cells to deliver therapeutics, is that we are the only one that has developed a technology that can work at the bedside. So, it's really the only one that can use the patient's blood, and we don't need to have a centralized lab. The beauty of this technology is that it is the only one that can use a sustained release formulations technology - that is, the one that is actually being developed for Ataxia Telangiectasia - on which we have completed phase III study results." "So, from the time of blood withdrawal from the patients and for our lead product, we take 50 milliliters of blood from the patient, a small amount, and within a couple of hours, patients can go home. They are only required to stay for the blood withdrawal and the blood infusions. The rest of the process is done by a small machine that is fully automated and operated by trained personnel." #EryDel #AtaxiaTelangiectasia #EryDex #RareDisease #AT EryDel.com Listen to the podcast here

Helping you get your blood healthy.

This week on "cast" (that's what the cool dogs are calling it) we chat about a super amazing technique to make artificial red blood cells with augmented abilities!  In Pet Science, you'll hear about how the average person is not the best at determining if a dog is fearful and thus possibly aggressive.  Our expert guest is Dr. Kory Evans who regals us with tales of his Amazon River research with electric fish.  Seriously, if that sentence doesn't get you interested YOU NEED TO TOUCH AN ELECTRIC EEL!  Ha!We also chat about fun stories about the new addition to the family...Beaker!Don't miss it!For Science, Empathy and Cuteness!!Dr. Kory Evans on TwitterDr. Kory Evan's website!The Bunsen WebsiteBunsen on Twitter:https://twitter.com/bunsenbernerbmdBunsen on Facebookhttps://www.facebook.com/bunsenberner.bmd/InstaBunsenhttps://www.instagram.com/bunsenberner.bmd/?hl=enGenius Lab Gear for 10% link!-10% off science dog bandanas, science stickers and science Pocket toolshttps://t.co/UIxKJ1uX8J?amp=1Support the showSupport the show (https://www.patreon.com/bunsenberner)