Gland of the male reproductive system in most mammals
POPULARITY
Categories
Today on AirTalk, financial payouts have plunged the city of Santa Monica's budget; how DTLA is turning its skyscrapers into housing units through the city's Adaptive Reuse Ordinance; Black Movie Soundtrack returns to the Hollywood Bowl; A recent study points to an increase in prostate cancer cases; what is 'AI psychosis?' and a new book on the contradictions and promise of Los Angeles Today on AirTalk, Santa Monica faces a fiscal emergency (0:15) DTLA revitalizes skyscrapers into housing (19:36) Black Movie Soundtrack returns to Hollywood Bowl (35:01) Prostate cancer rates increase after latest guideline update (51:27) AI psychosis (1:07:32) A new book on the promise of LA (1:23:00)
Could ongoing trials redefine the management of oligometastatic and advanced prostate cancer? In this installment of BackTable Tumor Board, leading prostate cancer experts Dr. Neeraj Agarwal, a medical oncologist from the University of Utah, and Dr. Tyler Seibert, a radiation oncologist from UC San Diego, join host Dr. Parth Modi to share their insights on the latest clinical trials and persistent challenges in managing prostate cancer.---This podcast is supported by:Ferring Pharmaceuticals https://ad.doubleclick.net/ddm/trackclk/N2165306.5658203BACKTABLE/B33008413.420220578;dc_trk_aid=612466359;dc_trk_cid=234162109;dc_lat=;dc_rdid=;tag_for_child_directed_treatment=;tfua=;gdpr=${GDPR};gdpr_consent=${GDPR_CONSENT_755};gpp=${GPP_STRING_755};gpp_sid=${GPP_SID};ltd=;dc_tdv=1---SYNPOSISThe multidisciplinary discussion addresses clinical decision-making in active surveillance versus early intervention, the role of PSMA PET imaging in detection and treatment planning, and evolving strategies for metastatic and castration-resistant disease. They also evaluate the therapeutic potential of alpha emitters and radioligand therapies, consider the evidence behind treatment intensification and de-intensification, and explore how these approaches can be individualized to optimize patient outcomes.---TIMESTAMPS0:00 - Introduction1:48 - Active Surveillance in Low-Risk Prostate Cancer7:08 - Molecular Testing and Risk Stratification8:28 - Radiation Therapy Approaches20:16 - PSA Recurrence and PSMA PET Scans32:40 - The Role of ADT37:15 - PSMA PET Scans40:58 - Genetic Testing in High-Risk and Metastatic Prostate Cancer46:54 - Treatment Intensification vs. De-Intensification Trials55:59 - Castration-Resistant Prostate Cancer
Alan interviews Tushar Sharma. Tushar Sharma grew up in a small village in India - but he had big plans. He graduated from IIT in Madras with a biotechnology degree. He completed his masters and PhD at UT Austin in Biomedical Engineering. In 2019, he invented a non-invasive surgical procedure for prostate patients that has minimal side effects. Website: www.VivifiMedical.com
Today on AirTalk, financial payouts have plunged the city of Santa Monica's budget; how DTLA is turning its skyscrapers into housing units through the city's Adaptive Reuse Ordinance; Black Movie Soundtrack returns to the Hollywood Bowl; A recent study points to an increase in prostate cancer cases; what is 'AI psychosis?' and a new book on the contradictions and promise of Los Angeles Today on AirTalk, Santa Monica faces a fiscal emergency (0:15) DTLA revitalizes skyscrapers into housing (19:36) Black Movie Soundtrack returns to Hollywood Bowl (35:01) Prostate cancer rates increase after latest guideline update (51:27) AI psychosis (1:07:32) A new book on the promise of LA (1:23:00) Visit www.preppi.com/LAist to receive a FREE Preppi Emergency Kit (with any purchase over $100) and be prepared for the next wildfire, earthquake or emergency!
Prostate cancer is the most common cancer diagnosed in men and the five year survival rate is 97%.
Deals and Steals from small businesses; Prostate cancer rates on the rise Learn more about your ad choices. Visit podcastchoices.com/adchoices
Deals and Steals from small businesses; Prostate cancer rates on the rise Learn more about your ad choices. Visit podcastchoices.com/adchoices
In this episode of AUANews Inside Track, Founder of Man vs. Prostate, Dr. Wayne Kuang, talks with Dr. Jay Raman as they discuss the Man vs. Prostate campaign and its growing role in men's health awareness. They explore how the movement expands the conversation beyond prostate cancer to include bladder health, benign prostatic hyperplasia (BPH) and the challenges men face in seeking timely care. This conversation highlights why prostate cancer awareness and bladder health must be recognized as public health priorities—and how advocacy and education can help redefine men's health.
Luna Robbie is totally into anal play and pegging with both men and women and she called in to talk all about it. Tune in to hear all the details including her first double penetration with a male and a female and exactly what went down, the first partner she got really into butt play with and what they enjoyed doing together, another dp threesome with her partner and another female and exactly what went down, when she got into pegging guys and why she enjoys it so much, how playing with herself with toys helped her become a better top and how that can help you too, how she incorporates lube into pegging and her “target practice” trick uses, exactly how she preps people before she pegs them and then exactly what she does when pegging them, how she stimulates the guys prostate plus a whole lot more. You can find her here: https://www.lunarobbie.com **To see HOT pics of LUNA ROBBIE plus my other female guests + hear anonymous confessions + get all the episodes early and AD FREE, join my Patreon! It's only $7 a month and you can cancel at any time. You can sign up here: https://www.patreon.com/StrictlyAnonymousPodcast and when you join, I'll throw in a complimentary link to my private Discord! MY BOOK IS NOW OUT FOR PRE-ORDER!!!! Strictly Anonymous Confessions: Secret Sex Lives of Total Strangers. A bunch of short, super sexy, TRUE stories. GET YOUR COPY NOW: https://amzn.to/4i7hBCd To join SDC and get a FREE Trial! click here: https://www.sdc.com/?ref=37712 or go to SDC.com and use my code 37712 Want to be on the show? Email me at strictlyanonymouspodcast@gmail.com or go to http://www.strictlyanonymouspodcast.com and click on "Be on the Show" Have something quick you want to confess while remaining anonymous? Call the CONFESSIONS hotline at 347-420-3579. You can call 24/7. All voices are changed. Sponsors: https://vb.health To get 10% off Drive Boost by VB Health use code: STRICTLY https://beducate.me/pd2528-anonymous Use code: ANONYMOUS to get 50% off your yearly pass plus get a 14-day money-back guarantee https://uberlube.com/discount/Strictly Use code: STRICTLY for 10% off Uberlube aka the BEST Lube EVER https://bluechew.com Get your first month of the new Blewchew Max FREE! use code: STRICTLYANON https://viia.co/STRICTLYANON Try VIIA and use code STRICTLYANON for great SEX and sleep https://butterwellness.com/ Use the code “STRICTLY” at checkout for 20% off your entire order To get $15 OFF your female oxytocin arousal tablets and more, use code STRICTLY here: https://shamelesscare.sjv.io/xLQ3Jv Follow me! Instagram https://www.instagram.com/strictanonymous/ Twitter https://twitter.com/strictanonymous?lang=en Website: http://www.strictlyanonymouspodcast.com/ Learn more about your ad choices. Visit megaphone.fm/adchoices
In this month’s edition of the Cancer Prevention Segment, X101's Matt Brooks speaks with Courtney Maxson, Senior Public Health Educator from the Cortland County Health Department. September is Prostate, Ovarian,[Read More...] The post Make Sure to Get Screened! September is Prostate, Ovarian, and Gynecologic Awareness Month appeared first on X101 Always Classic - WXHC.com.
Dr. Hoffman continues his conversation with Neil Levin, Senior Nutrition Education Manager at Protocol for Life Balance (PFLB) and Now Foods.
In this episode of the Intelligent Medicine podcast, Dr. Ronald Hoffman discusses men's health, a field that often receives less attention compared to women's health. He is joined by Neil Levin, Senior Nutrition Education Manager at Protocol for Life Balance (PFLB) and Now Foods. They explore the reluctance of men to visit doctors and how genetic and behavioral factors might contribute to men's health issues. The conversation delves into the specific challenges men face as they age, including declining testosterone levels, cardiovascular diseases, and prostate problems. Neil Levin introduces several PFLB products designed to support men's health, such as 'Virility for Men,' 'Prostate B,' and 'Raw Maca,' explaining their ingredients and benefits. They also highlight the importance of rigorous product quality control and the fight against counterfeit supplements in the industry.
Urologic oncologist Dr. Peter Carroll presents the latest research on active surveillance as a preferred approach for managing low-risk prostate cancer and selected cases of intermediate-risk disease. Drawing from two decades of UCSF data, he explains how long-term outcomes support the safety and effectiveness of delaying treatment for carefully monitored patients. Carroll emphasizes that surveillance decisions should be guided by MRI imaging, PSA density, cancer volume, histologic subtype, and genomic testing. He notes that while many men experience gradual changes over time, only a small percentage require immediate treatment. Carroll also discusses innovations such as AI-assisted pathology and risk profiling to reduce unnecessary procedures. His data-driven approach offers patients a personalized path that preserves quality of life without compromising outcomes. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 40801]
Urologic oncologist Dr. Peter Carroll presents the latest research on active surveillance as a preferred approach for managing low-risk prostate cancer and selected cases of intermediate-risk disease. Drawing from two decades of UCSF data, he explains how long-term outcomes support the safety and effectiveness of delaying treatment for carefully monitored patients. Carroll emphasizes that surveillance decisions should be guided by MRI imaging, PSA density, cancer volume, histologic subtype, and genomic testing. He notes that while many men experience gradual changes over time, only a small percentage require immediate treatment. Carroll also discusses innovations such as AI-assisted pathology and risk profiling to reduce unnecessary procedures. His data-driven approach offers patients a personalized path that preserves quality of life without compromising outcomes. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 40801]
In this episode, Dr. Rena Malik, MD welcomes Dr. Aaron Fischman, an expert in interventional radiology, to discuss prostate artery embolization as a minimally invasive treatment for enlarged prostate (BPH). Together, they explore how the procedure works, its success rates, what patients can expect before and after, and the latest advancements in technique and safety. Listeners will gain a comprehensive understanding of the benefits, risks, and evolving future of this innovative approach to men's health. Become a Member to Receive Exclusive Content: renamalik.supercast.com Schedule an appointment with me: https://www.renamalikmd.com/appointments ▶️Chapters: 00:00 Introduction 02:11 What is artery embolization? 03:56 Prostate artery embolization explained 05:57 Access through wrist vs. groin 08:56 Materials used for embolization 13:34 Patient workup and evaluation 16:35 Success rates and patient selection 21:06 Risks and complications 29:09 Long-term outcomes and recurrence 39:43 Finding an expert interventional radiologist Stay connected with Dr. Aaron Fischman on social media for daily insights and updates. Don't miss out—follow him now and check out these links! X - https://x.com/bonesz?s=21&t=capJF_nC6iMJjJWqHuZeYw LINKEDIN - https://www.linkedin.com/in/aaron-fischman-md-fsir-fcirse-fsvm-213a234?utm_source=share&utm_campaign=share_via&utm_content=profile&utm_medium=ios_app YOUTUBE - https://youtube.com/@aaronfischmanmd?si=wP7jb0Za32H9Y_mE Let's Connect!: WEBSITE: http://www.renamalikmd.com YOUTUBE: https://www.youtube.com/@RenaMalikMD INSTAGRAM: http://www.instagram.com/RenaMalikMD TWITTER: http://twitter.com/RenaMalikMD FACEBOOK: https://www.facebook.com/RenaMalikMD/ LINKEDIN: https://www.linkedin.com/in/renadmalik PINTEREST: https://www.pinterest.com/renamalikmd/ TIKTOK: https://www.tiktok.com/RenaMalikMD ------------------------------------------------------ DISCLAIMER: This podcast is purely educational and does not constitute medical advice. The content of this podcast is my personal opinion, and not that of my employer(s). Use of this information is at your own risk. Rena Malik, M.D. will not assume any liability for any direct or indirect losses or damages that may result from the use of information contained in this podcast including but not limited to economic loss, injury, illness or death. Learn more about your ad choices. Visit megaphone.fm/adchoices
Send us a textWhat if AI could predict cancer outcomes better than traditional methods—and at a fraction of the cost? In this episode, I explore how multimodal AI is reshaping lung and prostate cancer predictions and why integration challenges still stand in the way.Episode Highlights with Timestamps:[00:02:57] Agentic AI in toxicologic pathology – what it is and how it could orchestrate workflows.[00:05:40] Grandium desktop scanners – making histology studies more accessible and efficient.[00:08:03] Clover framework – a cost-effective multimodal model combining vision + language for pathology.[00:13:40] NSCLC study (Beijing Chest Hospital) – AI predicts progression-free and overall survival with high accuracy.[00:17:58] Prostate cancer prognostic model (Cleveland Clinic & US partners) – validating AI-enabled Pathomic PRA test.[00:23:35] Thyroid neoplasm classification – challenges for AI in distinguishing overlapping histopathological features.[00:34:49] Real-world Belgium case study – AI integration into prostate biopsy workflow reduced IHC testing and turnaround time.[00:41:03] Lessons learned – adoption hurdles, system integration, and why change management is essential for successful digital transformation.Resources from this EpisodeWorld Tumor Registry – A global open-access repository for histopathology images: World Tumor RegistryBeijing Chest Hospital NSCLC AI Prognostic Study – Prognosis prediction using multimodal models.Cleveland Clinic Pathomic PRA Study – Independent validation of AI-enabled prostate cancer risk assessment.Grandium Scanners – Compact desktop scanners for histology slides: Grandium.aiSupport the showBecome a Digital Pathology Trailblazer get the "Digital Pathology 101" FREE E-book and join us!
A cancer label can change the course of a man's life, but too often that label is built on shaky ground. The Gleason score and routine biopsies remain standard, yet these methods can mislead patients into unnecessary treatments that compromise both health and quality of life.In this episode, Dr. Stephen Petteruti challenges outdated diagnostic tools and exposes the risks behind relying on them. He explains how advanced imaging technologies like prostate MRI and PSMA PET scans, paired with precise biomarker strategies, are reshaping the future of prostate care.The goal isn't just early detection, it's accurate understanding. If proactive healthcare and clear answers matter to you, watch the full episode of Is It Really Cancer? Rethinking Prostate Diagnosis and the Gleason ScoreEnjoy the podcast? Subscribe and leave a 5-star review on your favorite platforms.Dr. Stephen Petteruti is a leading Functional Medicine Physician dedicated to enhancing vitality by addressing health at a cellular level. Combining the best of conventional medicine with advancements in cellular biology, he offers a patient-centered approach through his practice, Intellectual Medicine 120. A seasoned speaker and educator, he has lectured at prestigious conferences like A4M and ACAM, sharing his expertise on anti-aging. His innovative methods include concierge medicine and non-invasive anti-aging treatments, empowering patients to live longer, healthier lives.Website: www.intellectualmedicine.com Website: https://www.theprostateprotocol.com/ YouTube: https://www.youtube.com/@intellectualmedicine LinkedIn: https://www.linkedin.com/in/drstephenpetteruti/ Instagram: instagram.com/intellectualmedine Consultation: https://www.theprostateprotocol.com/book-a-consultation Store: https://www.theprostateprotocol.com/store Community: https://www.theprostateprotocol.com/products/communities/v2/fightcancerlikeaman/home Disclaimer: The content presented in this video reflects the opinions and clinical experience of Dr. Stephen Petteruti and is intended for informational and educational purposes only. It is not medical advice and should not be used as a substitute for professional diagnosis, treatment, or guidance from your personal healthcare provider. Always consult your physician or qualified healthcare professional before making any changes to your health regimen or treatment plan.Produced by https://www.BroadcastYourAuthority.com
Texts Can't be responded to, so email me!So good right?FUCK I love making these!You should hear the full version.....Support the showOnlyFans Support the damn show. It's NOT that hard....But I Can Make It Hard... EMAIL Me at: KrystineKellogg@gmail.com https://www.krystinekellogg.com/ This podcast is literally a passion project. To date, this podcast has between 15k and 20k downloads per month. And yet, it cannot pay for it's own hosting costs, much less the production costs incurred.I take donations. And those donations go directly towards the production of this podcast. Want more? Then donate so that I can keep this damn thing going!VENMO: @KrystineKelloggCashApp: $KrystineKellogg
This podcast description was blatantly written by AI... Join Clint, Meg, and Dan, with Ash London for a fun-filled episode of The Edge Breakfast Podcast! They launch into discussions about childhood crushes, featuring famous moments like Cameron Diaz in 'The Mask' and Megan Fox in 'Transformers.' Ash tries her best to join the Warriors bandwagon with some hard-hitting sports quizzes, and Dan reveals juicy details about an awkward encounter involving an elevator and music artist Ruel. Special guest Christopher Luxon joins to talk politics and the rising cost of groceries. Prepare for laughs, heart-to-hearts, and a mix of everything you love about the show! 00:00 Welcome to the Clint, Megan, Dan Podcast02:05 Throwback Song Debate06:16 Zoo Adventures and Animal Antics09:10 Dentist Training and Medical Mishaps16:00 Adoption News and Celebrity Gossip25:02 Sexual Awakenings and Movie Memories39:31 Bandwagon Warriors Fans and Ash's Challenge43:18 Michelle's Terminal Cancer Journey49:46 Dan's New Cash Contest and Christopher Luxon Interview01:04:03 Debate: Who Sits in the Front Seat?01:16:47 Pranking Lily with Ruel
In our final hour, we hear more from Jim Gilmore, and we close out the show. . . .
Welcome back to BUTT HONESTLY, the podcast that isn't afraid to poke around where the sun doesn't shine. This week, we're zeroing in on the almighty prostate—and let's just say, things get… stimulating.First up, a Booty Gang member writes in with questions about sex after prostate cancer, while another swears his prostate might be broken (spoiler: it's not Amazon Prime, it doesn't come with a warranty). And if that weren't enough, a certain pig on the prowl checks in to let us know his prostate just got absolutely wrecked—but in the best possible way.Meanwhile, Dr. Carlton slides into the weird and wonderful world of his prison DMs (apparently, orange really is the new black), while Dangilo shares a bloody IV situation that'll make you clutch your pearls… or at least your veins.Oh, and mark your calendars: Slutter Camp is happening August 30. If you're not ready, now's the time to stretch, hydrate, and maybe invest in a jockstrap or two.As always, the guys wrap it all up with their “Love Language of the Week” — because after all the prostate poking, prison proposals, and IV drama, you'll need a soft landing.Advertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
Kevin Martin a 62 year old with Prostate cancer joins with Dr. Atish Choudhury to share his story, then the Kee family join to share how cancer has affected them. World Champions Derek Lowe and Brian Hoyer join.
Send us a textIf our visual scoring is still based on gut feeling, how do we scale precision? In this week's DigiPath Digest, I explored four new AI-focused papers that could reshape how we diagnose prostate, bladder, gastroesophageal, and endocrine cancers.From automated IHC scoring to predicting urethral recurrence post-cystectomy, these studies highlight the growing value—and responsibility—of integrating AI into our pathology workflows.And yes, I also reveal where to get my histology-inspired earrings
Drinking Beer can do good for the world. Rick Lyke of Pints for Prostates is here to talk about his organization and the evolution of the Denver Rare Beer Tasting. For more Drink Beer, Think Beer check out All About Beer.SponsorsDogfish Head Craft BreweryCalling all hop heads! Dogfish Head's 60 Minute IPA is a fantastically hoppy India Pale Ale that's beautifully balanced thanks to their unique continual hopping method. Delivering a pungent hop flavor that isn't crushingly bitter, 60 Minute is continually hopped throughout the boil for a full 60 minutes … starting to see where the name comes from?! Check out dogfish.com to learn more and to find some 60 Minute near you! Dogfish Head Craft Brewery, Milton, DE. Please drink responsibly.Stomp StickersStomp Stickers is a proud member of the Brewers Association that produces a wide variety of printed brewery products such as beerlabels, keg collars, coasters, beer boxes and much more. Stomp's website features an easy-to-use design tool, low quantity orders, fast turn times, and free domestic shipping. Visit StompStickers.com and use code FIRSTRUN for 15% off your first order.The 5th IngredientIf you're running a brewery owner or operator, Beer30 by The 5th Ingredient is the ultimate command center. The most powerful brewery management software on the market, Beer30 handles the entire brewing workflow, from recipe development to production. Once your beer is brewed and ready, it seamlessly manages your inventory and streamlines your brewery's sales and distribution--all in the same easy-to-use platform. Beer30 lets you get back to the beer and the people that made you fall in love with this industry in the first place. And no other brewery management software gives you the ability to truly master your business and get the insights that you need to thrive in an increasingly competitive industry. Visit the5thingredient.com/AllAboutBeer today to learn more and receive 3 free months of Beer30.Host: John HollGuest: Rick LykeSponsors: All About Beer, Stomp Stickers, The 5th Ingredient, Dogfish HeadTags: Hops, Denver, Tasting, Rare Beer, CharityPhoto: John Holl
On Today's show, A woman's friend, returning from interstate, expresses a desire to stay and have a sexual encounter. The friend seduces the woman's husband, leading to a week of intense sexual activities, including public displays and discreet encounters. The woman joins in, enjoying the shared experience, but feels exhausted by the end.A young man, new to the swinging scene, participates in a gangbang event featuring a MILF hotwife. Despite initial nerves, he enjoys the organized chaos, witnessing and participating in multiple rounds of sexual encounters. He unexpectedly ejaculates prematurely, leading to laughter and a memorable experience.A woman describes her sexual encounter with a man, highlighting the intense pleasure he experiences when she stimulates his prostate. The story emphasizes the mutual satisfaction and the unique connection they share through this intimate act.A man, engaged to a younger virgin woman, suggests she have sexual experiences before their wedding to ensure she doesn't feel cheated. Despite cultural and religious constraints, they find creative ways to explore their desires, leading to a complex dynamic of trust and exploration.That and so, so much more. ASN Magazine Awards: Purchase Show Tickets and Hotel TicketsI want to hear from you too! If you have a secret story or experience you've been dying to share, now's your chance. You can write to me directly at Nikky@dearnikky.com or submit your confession anonymously at DearNikky.com/confessions.Perhaps you have an erotic fantasy that's been burning inside you, or maybe you just want to say hello - whatever it is, I want to hear from you!By submitting a confession and/or question you certify the following stipulations to be true:You are the sole creator of the submission;You are 18 years of age or older and legally able to write, submit erotic or pornographic materialStories including Bestiality, Incest and Incest Fantasies, Underage Role-Play, Rape Sex, Rape Fantasies or other non-consensual content or Racial slurs will not be aired.We reserve the right to change names or other identifiable information.You are releasing all rights to this creationIf you've enjoyed tuning in to my show each week (and getting an inside look at some very private lives), please take a moment leave review wherever listen: whether that Apple Podcasts Spotify Google other platform helps new listeners discover helps spread word keeps conversation going Thank loving supportDear Nikky: Sex Confessions From People Just Like You is out now!You can email me at Nikky@dearnikky.com. You can find me also a Twitter, Instagram, Facebook. Become a supporter of this podcast: https://www.spreaker.com/podcast/dear-nikky-hidden-desires--6316414/support.
BUFFALO, NY – August 11, 2025 – A new #researchpaper was #published in Volume 16 of Oncotarget on July 25, 2025, titled “Dissecting the functional differences and clinical features of R-spondin family members in metastatic prostate cancer.” In this study, researchers led by first author Aiden Deacon and corresponding author Justin Hwang from the University of Minnesota-Twin Cities investigated a group of genes known as the R-spondin family (RSPO1/2/3/4) in advanced prostate cancer (PC). The RSPO gene family regulates Wnt signaling, a pathway involved in cancer progression. Prostate cancer is the most common cancer among men in the United States and becomes especially dangerous when it spreads beyond the prostate. Most patients are treated with hormone therapies that target the androgen receptor; however, many tumors eventually become resistant. The research team analyzed thousands of tumor samples and found that RSPO2 alterations were more common than changes in other R-spondin genes or even some well-known cancer-related genes like CTNNB1 and APC. RSPO2 amplification occurred in over 20% of metastatic prostate cancer. Patients with these alterations showed signs of more aggressive disease, including higher mutation rates and greater tumor complexity. Using laboratory models, the team discovered that RSPO2 increases cancer cell growth and triggers a biological process called epithelial-mesenchymal transition (EMT). EMT is known to promote tumor spread and resistance to standard treatments. Unlike other genes in the same pathway, RSPO2 also appeared to reduce the activity of androgen receptor genes, suggesting it drives a type of prostate cancer that no longer relies on hormones for growth. “In cell lines, RSPO2 overexpression caused up-regulation of EMT pathways, including EMT-regulatory transcription factors ZEB1, ZEB2, and TWIST1.” Importantly, RSPO2 showed structural differences from other R-spondin proteins, which may allow researchers to design drugs that specifically block its activity. Current therapies targeting the Wnt pathway are limited, and there are no approved drugs that inhibit RSPO2. However, this study highlights RSPO2 as a promising therapeutic target, especially for patients who do not respond to existing hormone-based treatments. This research adds critical knowledge about how aggressive prostate cancers develop and persist despite therapy. The identification of RSPO2 as a key driver of disease progression opens new possibilities for treatment strategies aimed at improving outcomes for patients with advanced prostate cancer. DOI - https://doi.org/10.18632/oncotarget.28758 Correspondence to - Justin Hwang - jhwang@umn.edu Video short - https://www.youtube.com/watch?v=iyu5D_c1dbY Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28758 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, RSPO2, prostate cancer, Wnt signaling, genomics, therapeutics To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM
Aug. 11, 2025 ~ Discover a breakthrough in men's health that's changing lives. This month's “HealthWatch,” examines prostate artery embolization (PAE), a minimally invasive treatment for enlarged prostate that offers relief without surgery or side effects. Listen as Dr. Scott Schwartz of the Michigan Institute of Urology's Interventional Radiology Center tells us how this game-changing procedure is helping men reclaim comfort, confidence, and control.
Aug. 11, 2025 ~ Discover a breakthrough in men's health that's changing lives. This month's “HealthWatch,” examines prostate artery embolization (PAE), a minimally invasive treatment for enlarged prostate that offers relief without surgery or side effects. Listen as Dr. Scott Schwartz of the Michigan Institute of Urology's Interventional Radiology Center tells us how this game-changing procedure is helping men reclaim comfort, confidence, and control.
Aug. 11, 2025 ~ Discover a breakthrough in men's health that's changing lives. This month's “HealthWatch,” examines prostate artery embolization (PAE), a minimally invasive treatment for enlarged prostate that offers relief without surgery or side effects. Listen as Dr. Scott Schwartz of the Michigan Institute of Urology's Interventional Radiology Center tells us how this game-changing procedure is helping men reclaim comfort, confidence, and control.
Do you have any unusual daily habits? Doug does and sets off a convo, plus what sent you to the principal's office? Then #dadjokes involving the prostate for the #health.
UCSF researchers June Chan and Stacey Kenfield share evidence-based strategies for improving prostate cancer outcomes through exercise and diet. They highlight studies showing that physical activity—including resistance and high-intensity interval training—is linked to lower risk of prostate cancer progression and death. They discuss plant-based diets, dietary indices, and specific foods like tomatoes, fish, and nuts, along with the benefits of substituting plant oils for butter. Their analysis includes findings on racial disparities and underscores the need for inclusive research. They also describe current clinical trials exploring lifestyle tools and offer guidance on navigating diet and exercise choices during cancer survivorship. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 40808]
UCSF researchers June Chan and Stacey Kenfield share evidence-based strategies for improving prostate cancer outcomes through exercise and diet. They highlight studies showing that physical activity—including resistance and high-intensity interval training—is linked to lower risk of prostate cancer progression and death. They discuss plant-based diets, dietary indices, and specific foods like tomatoes, fish, and nuts, along with the benefits of substituting plant oils for butter. Their analysis includes findings on racial disparities and underscores the need for inclusive research. They also describe current clinical trials exploring lifestyle tools and offer guidance on navigating diet and exercise choices during cancer survivorship. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 40808]
UCSF researchers June Chan and Stacey Kenfield share evidence-based strategies for improving prostate cancer outcomes through exercise and diet. They highlight studies showing that physical activity—including resistance and high-intensity interval training—is linked to lower risk of prostate cancer progression and death. They discuss plant-based diets, dietary indices, and specific foods like tomatoes, fish, and nuts, along with the benefits of substituting plant oils for butter. Their analysis includes findings on racial disparities and underscores the need for inclusive research. They also describe current clinical trials exploring lifestyle tools and offer guidance on navigating diet and exercise choices during cancer survivorship. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 40808]
UCSF researchers June Chan and Stacey Kenfield share evidence-based strategies for improving prostate cancer outcomes through exercise and diet. They highlight studies showing that physical activity—including resistance and high-intensity interval training—is linked to lower risk of prostate cancer progression and death. They discuss plant-based diets, dietary indices, and specific foods like tomatoes, fish, and nuts, along with the benefits of substituting plant oils for butter. Their analysis includes findings on racial disparities and underscores the need for inclusive research. They also describe current clinical trials exploring lifestyle tools and offer guidance on navigating diet and exercise choices during cancer survivorship. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 40808]
Walt Murray rounds out his week with Dave and Eric discussing The Naked Gun, Minute 15 - The Knucklecracker Sweet. The press conference unfolds, Frank switches microphones, insults a foreign nation's government, and relieves himself. Check out Walt's podcast, the Wilder Ride: https://thewilderride.libsyn.com/
The rollercoaster of medical school transitions is hitting some peaks, from the first nerve-wracking days of clerkships to the unglamorous realities of OB-GYN rotations. M3 Elvire Nguepnang, M2 Gizzy Lundquist, M3 Jeff Goddard, and M1 Katherine Yu open up about the leap from textbooks to patient care, beginning advanced clerkships, and just staying on the path—and why it's okay to feel a little lost. Along the way, they share their experiences with delivering placentas, unpack how seemingly minor lessons from preclinical years suddenly become crucial in the real world, and the new sensory ability they'd choose if they could.
BUFFALO, NY - July 29, 2025 – A new #research paper was #published in Volume 16 of Oncotarget on July 25, 2025, titled “Comprehensive genomic profiling of over 10,000 advanced solid tumors.” In this study, led by Jean-Paul De La O from Exact Sciences Corporation, researchers analyzed data from over 10,000 solid tumor samples from patients with advanced cancer and found that more than 90 percent contained genetic changes that could guide treatment. This work demonstrates the growing impact of large-scale tumor DNA and RNA testing on patient care. The researchers retrospectively analyzed OncoExTra assay information for 31 types of cancer, including breast, colorectal, prostate, lung, and ovarian cancers. Their analysis revealed that nearly a third of patients had alterations associated with approved drugs for their specific cancer, while another third had changes linked to therapies approved for other cancers. These results show that detailed genetic profiling could expand treatment choices. “Biomarkers associated with on- or off-label FDA-approved therapies were detected in 29.2% and 28.0% of samples, respectively.” Another relevant discovery was that many important mutations occurred at very low levels, which are often missed by simpler tests. By using a broad and highly sensitive approach, the scientists were able to identify these rare mutations. They also reported that 7.5 percent of samples carried gene fusions, unusual genetic events that can drive cancer growth. Such findings can be critical in selecting therapies that specifically target these abnormalities. The study also highlighted the value of RNA sequencing in detecting fusion events that traditional DNA tests might miss. Prostate cancer and certain sarcomas showed particularly high rates of these fusion alterations. This type of information can refine cancer diagnosis and improve therapy planning. In addition, the researchers identified changes in several major cancer-related pathways, including those that control cell growth, DNA repair, and immune system response. Alterations in these pathways can point to newer treatment options, such as immunotherapy or drugs designed to block specific cell signals. Overall, this study shows that comprehensive genomic profiling can guide more personalized cancer care by identifying mutations, gene fusions, and other molecular patterns. Advanced testing methods like the OncoExTra assay reveal treatment opportunities even in advanced cancers, ensuring that subtle but important genetic changes are detected. DOI - https://doi.org/10.18632/oncotarget.28757 Correspondence to - Jean-Paul De La O - jdelao@exactsciences.com Video short - https://www.youtube.com/watch?v=awiRhDfiMTE Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28757 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, solid tumors, comprehensive genomic profiling, matched therapy, gene fusions, limit of detection To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM
Prostate cancer is the second most diagnosed cancer among men worldwide and remains a leading cause of cancer-related death. While early forms of the disease can usually be treated successfully, advanced cases remain a major challenge. Scientists have now discovered a new potential way to slow the growth of advanced, treatment-resistant prostate cancer. These results were recently published in Volume 16 of Oncotarget by researchers from the University of Cincinnati College of Medicine. Understanding Advanced Prostate Cancer Early-stage prostate cancer can often be treated successfully. Most treatments work by lowering testosterone levels or blocking the hormone from activating the androgen receptor (AR), which drives cancer growth. In some patients, however, the disease progresses to castration-resistant prostate cancer (CRPC). Even with drastic reductions in testosterone levels, the tumors continue to grow at this stage. CRPC is much more difficult to treat, and current therapies such as hormone blockers or chemotherapy typically extend life by only a few months. One reason for this resistance is that cancer cells often switch to a different form of the androgen receptor called AR-V7. This variant remains permanently active, even without testosterone, making hormone-based drugs less effective. Because of this, new treatment strategies that work independently of hormone levels are needed. The Study: Targeting a New Weakness in Prostate Cancer Cells In the study titled “Targeting PCNA/AR interaction inhibits AR-mediated signaling in castration resistant prostate cancer cells,” researchers Shan Lu and Zhongyun Dong from the University of Cincinnati College of Medicine investigated a new way to block CRPC growth. Full blog - https://www.oncotarget.org/2025/07/29/a-new-way-to-target-resistant-prostate-cancer-cells/ Paper DOI - https://doi.org/10.18632/oncotarget.28722 Correspondence to - Zhongyun Dong - dongzu@ucmail.uc.edu Video short - https://www.youtube.com/watch?v=fiJWZ_fKxgs Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28722 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, PCNA, androgen receptor, PCNA inhibitors, AR splicing variants, CRPC To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM
In Dr. Bob's latest book, he shares how healing your body with a pure diet and exercise can go a long way in preventing unnecessary operations and procedures and help with thyroid and prostate issues.
Prostate cancer and its treatments can significantly impact bone health, increasing the risk of fractures and weakening the immune system. Dr. Terence Friedlander explains how hormone therapy, radiation, and chemotherapy contribute to bone loss and highlights the importance of regular monitoring. He reviews the role of bone-building cells and the effects of osteopenia and osteoporosis, conditions that become more common with age and can be worsened by cancer therapies. Friedlander outlines tools like the Dexa scan and FRAX calculator to assess bone density and fracture risk, and discusses prevention strategies, including adequate calcium and vitamin D intake, weight-bearing exercise, and the use of medications like bisphosphonates and denosumab. He emphasizes proactive bone care for men with prostate cancer to help reduce complications and improve outcomes. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 40812]
Dr. Steven Seyedin presents an overview of PSA recurrence and risk factors for assessment. A PSA test is a blood test used to detect prostate-specific antigen (PSA) levels in the blood, which can be elevated in cases of prostate cancer and is a common screening tool. He explains how PET, CT, and MRI work, highlighting the precision of PSA PET in detecting cancer spread by targeting PSA proteins on tumor cells. This imaging method combines PET and CT to reveal metastatic disease with greater accuracy than traditional scans. Seyedin addresses the strengths of different imaging agents, emphasizing that access, not brand, is key. He also cautions against false positives, especially in bone lesions, which can mislead diagnosis. By improving staging accuracy, PSA PET supports better treatment planning and outcomes. Ongoing studies explore its use earlier in diagnosis, potentially replacing biopsy or MRI in select cases. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 40805]
Dr. Steven Seyedin presents an overview of PSA recurrence and risk factors for assessment. A PSA test is a blood test used to detect prostate-specific antigen (PSA) levels in the blood, which can be elevated in cases of prostate cancer and is a common screening tool. He explains how PET, CT, and MRI work, highlighting the precision of PSA PET in detecting cancer spread by targeting PSA proteins on tumor cells. This imaging method combines PET and CT to reveal metastatic disease with greater accuracy than traditional scans. Seyedin addresses the strengths of different imaging agents, emphasizing that access, not brand, is key. He also cautions against false positives, especially in bone lesions, which can mislead diagnosis. By improving staging accuracy, PSA PET supports better treatment planning and outcomes. Ongoing studies explore its use earlier in diagnosis, potentially replacing biopsy or MRI in select cases. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 40805]
“Next-generation sequencing, or NGS, can be used to help us determine if the patient has specific biomarkers we can identify and use to target for treatment. Certain findings can tell us if a particular treatment might work for that patient, and we can see if there are any genetic variants we might have a biomarker targeted agent to use to treat them with,” ONS member Jackie Peterson, MSN, RN, OCN®, NE-BC, MBA, ambulatory nurse manager at the University of Chicago Medical Center in Illinois, told Lenise Taylor, MN, RN, AOCNS®, BMTCN®, oncology clinical specialist at ONS, during a conversation about prostate cancer and biomarker testing. This podcast is sponsored by AstraZeneca and is not eligible for NCPD contact hours. ONS is solely responsible for the criteria, objectives, content, quality, and scientific integrity of its programs and publications. Music Credit: “Fireflies and Stardust” by Kevin MacLeod Licensed under Creative Commons by Attribution 3.0 Episode Notes This episode is not eligible for NCPD. ONS Podcast™ episodes: Episode 324: Pharmacology 101: LHRH Antagonists and Agonists Episode 321: Pharmacology 101: CYP17 Inhibitors Episode 180: Learn How Nurse Practitioners Use Biomarker Testing in Cancer Care ONS Voice articles: An Oncology Nurse's Guide to Cascade Testing Genetic Disorder Reference Sheet: BRCA1 and BRCA2 Hereditary Disorders Genetic Disorder Reference Sheet: Lynch Syndrome (Hereditary Nonpolyposis Colorectal Cancer) Germline and Somatic Variants: What Is the Difference? Help Patients Understand Genomic Variants of Unknown Significance Prostate Cancer Clinical Trials Don't Reflect Racial Diversity—And It's Getting Worse Over Time Prostate Cancer Disparities Disappear With Equal Access to Care Prostate Cancer Prevention, Screening, Treatment, and Survivorship Recommendations The Case of the Genomics-Guided Care for Prostate Cancer ONS book: Understanding Genomic and Hereditary Cancer Risk: A Handbook for Oncology Nurses ONS course: Genomic Foundations for Precision Oncology Clinical Journal of Oncology Nursing articles: Metastatic Prostate Cancer: An Update on Treatments and a Review of Patient Symptom Management Prostate Cancer: How Nurse Practicioners Can Aid in Disease Diagnosis and Management Oncology Nursing Forum article: Identification of Symptom Profiles in Prostate Cancer Survivors Other ONS Resources: Biomarker Database (refine by prostate cancer or specific biomarkers) Clinical tool/case study: Biomarker Testing in Prostate Cancer: The Role of the Oncology Nurse Genomics and Precision Oncology Learning Library Huddle Card: Genomic Biomarkers Infographic: Talking to Your Patient About a Germline Variant of Uncertain Significance (VUS) American Cancer Society - Genetic Testing and Counseling for Prostate Cancer Risk American Cancer Society - Prostate Cancer Clinicaltrials.gov National Cancer Institute - Prostate Cancer National Comprehensive Cancer Network ZERO Prostate Cancer To discuss the information in this episode with other oncology nurses, visit the ONS Communities. To find resources for creating an ONS Podcast club in your chapter or nursing community, visit the ONS Podcast Library. To provide feedback or otherwise reach ONS about the podcast, email pubONSVoice@ons.org. Highlights From This Episode “Some of the risk factors for developing prostate cancer include age, race, family history, and certain genetic changes or variants. Prostate cancer has some hereditary components, but most prostate cancer occurs in men without any significant family history of it.” TS 1:31 “Key biomarkers include PSA and prostate cancer gene 3, which is PCA3, and prostate-specific membrane antigen, or PSMA. Other biomarkers that are important for us to test include BRCA1, BRCA2, and Lynch syndrome–associated genes, which are MLH1, MSH2, MSH6, PMS2, and EPCAM. Biomarkers can be collected via your blood, urine, saliva, or tissue samples, so these are different ways that we can test and look for biomarkers in our patients.” TS 3:24 “It does matter how advanced the disease is. Usually, for our castrate-sensitive patients, they respond better to androgen deprivation therapy because that really is slowing down the growth of the cancer by reducing the available testosterone that the cancer needs to grow. Whereas our patients that are more advanced and have castrate-resistant prostate cancer, that cancer will continue to grow despite having the lowered testosterone levels, so they might need additional layers of treatment to really get their cancer under control.” TS 7:50 “When I talk to [patients] about biomarker testing, I tell them it's another tool in our toolbox that we can use to help us determine if they might benefit from other therapy options now or in the future. I tell them that sometimes we'll get a report back with a variant of unknown significance, and basically that means that we don't really know whether or not this has an impact on their health or risk factors for the disease. That can sometimes be a little bit of a concern for these patients, so we just have to reassure them that we're continually doing research around biomarker testing. The science is always advancing, so if there's something that [researchers] find in the future, we'll make them aware of that.” TS 9:08 “One of the biggest topics I think about is the inequity that exists in biomarker testing and research, especially surrounding the African American population. When these tests were developed, that population really wasn't studied as much, so there's not a lot of good data yet to make a decision or impact on those patients and that population.” TS: 12:30
Can pygeum help men with benign prostatic hyperplasia? Here's the research, how much might work, and what to look for when shopping for a pygeum supplement. After that lets get out your tape measure because we'll look at the intriguing research involving calf circumference and the risk of death. In short, the thicker the calves the better. Ill discuss the evidence and tell you how many inches/CM to look for and what to look out for too. This is episode 223. Pygeum video review https://youtu.be/yYo6NRlyC3Q Full review at https://supplementclarity.com/does-pygeum-africanum-really-help-with-bph-what-the-research-actually-says/ Calf circumference research: https://www.tiktok.com/t/ZP8k8jm19/ Read My Rhabdo Book Education is the best defense against getting rhabdomyolysis. I've been teaching about rhabdo for over 10 years. If you are in the US, you can order my book directly from me. · Purchase My Rhabdo Book · Order on Amazon (affiliate link) Supplement Facts Coffee Mug: https://joecannon.creator-spring.com/listing/supplement-facts-mug Consultations https://supplementclarity.com/private-consultations/ Connect With Me · Joe-Cannon.com · SupplementClarity.com · YouTube · Tiktok About Me For over 30 years, I've been sorting nutrition facts from fiction, busting myths and helping people understand dietary supplements using clinical research as my litmus test. I am unbiased. I analyze the research so you don't have to. I have an MS in exercise science and a BS in biology & chemistry. I've written several books, including Rhabdo, the first book about exercise-induced rhabdomyolysis. Disclaimer Episodes are for information only. I'm NOT a medical doctor. NO medical advice is given or implied. ALWAYS consult your physician for the best health advice for you. I participate in the Amazon Associates program which means if you click on a link to amazon and make a purchase, I may make a small commission at no extra cost to you.
Prostate biopsy is evolving rapidly, offering urologists more precision - but also more decisions. In this episode of BackTable Urology, Dr. Ricardo Sánchez-Ortiz, a pioneer in robotic surgery and neuro-urology in Puerto Rico, joins host Dr. Jose Silva to discuss the shifting landscape of prostate biopsy and emerging strategies that improve accuracy and personalize care. --- SYNPOSIS The conversation explores the transition from transrectal to transperineal prostate biopsy, emphasizing the role of PSA density and modern imaging in refining patient selection. Dr. Sánchez-Ortiz highlights the value of biomarkers in improving diagnostic accuracy and focal therapy as a promising, less invasive treatment option.Beyond clinical innovations, the doctors also discuss the importance of communication in urology practice. Dr. Sánchez-Ortiz shares how tools like WellPrept can enhance patient education and engagement, reinforcing the need for individualized care strategies in an increasingly complex diagnostic landscape. --- TIMESTAMPS 00:00 - Introduction 02:14 - Evolution of Prostate Biopsy Methods17:51 - Transperineal vs. Transrectal Approaches22:52 - Use of Sedation35:10 - PSA Screening41:48 - Rise in Metastatic Prostate Cancer50:44 - Potential of Focal Ablation55:58 - Use of WellPrept --- RESOURCES WellPrept:https://www.wellprept.com/
DNS Podcast 273 Dave Crosland & Scott McNally 2:00 DEA Pressure on China Raws 5:05 Nandrolone Profile 8:30 Deca Pros and Cons 11:45 Lower vs High Dose Sides 12:45 Lowest Doses of Deca and NPP for Muscle Building 13:30 Finasteride Use with Nandrolone 16:40 NPP Vs Deca 20:00 Mental Well Being on Deca 22:30 Deca & Fertility 24:00 Dosages For Nandrolone & Joints 27:00 Carrying Gear in the Airport in UK 29:00 Emotional Stability on Deca 31:30 Top 3 OTC supplements for gear users 34:40 BPC157 & Kidneys 38:40 Is 2iu GH effective for a younger guy? 41:00 Increasing Appetite with MK677 42:30 Any use for epistane today? 44:35 Primo & Mast on the Prostate 46:25 How Long To Stay On Cycle? 47:50 Price Increase for Labs 50:50 Fixing Bicep Tendonitis 53:21 Setting up a 1 Year Growth Phase 56:00 Mega Dosing Melatonin 58:30 SLU-PP-332 Average Doses And Fat Loss 1:00:45 Sleep Issues On Test Cycle 1:02:30 Uncle Dave's Wisdom ✅ ✅ Modern Aminos New Peptide and Research Chem Affiliate : https://tinyurl.com/y4nts94n ✅ ✅Code THINKBIG ✅ Parabolic Peptides Great Research Tabs and Peps https://tinyurl.com/ycpnbjzd ✅ ✅Code THINK
Jay sings a sexy theme song for the SiriusXM lobby and Bob takes it further by role playing during it. | Jay's new favorite performer is Frosted Jake who creates show tunes about everyday events. | Comedian Che Durena conducts a science experiment that includes female fluids and a beer bong. Bob learns a lot about women by watching a video of Che in his disgusting laboratory. Bobby and Jay start arguing in front of their new friend. Che Durena hosts "Dark Holes" on the Gas Digital Network and will be performing at Just For Laughs in July. *To hear the full show to go www.siriusxm.com/bonfire to learn more FOLLOW THE CREW ON SOCIAL MEDIA: @thebonfiresxm @louisjohnson @christinemevans @bigjayoakerson @robertkellylive @louwitzkee @jjbwolfSubscribe to SiriusXM Podcasts+ to listen to new episodes of The Bonfire ad-free and a whole week early. Start a free trial now on Apple Podcasts or by visiting siriusxm.com/podcastsplus.
See omnystudio.com/listener for privacy information.