Neuro-Oncology: The Podcast

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Neuro-Oncology: The Podcast will keep you up to date about the latest advances in the field as we present conversations with the authors of selected papers from Neuro-Oncology and its sister journals, Neuro-Oncology Practice and Neuro-Oncology Advances.

Neuro-Oncology


    • May 17, 2025 LATEST EPISODE
    • monthly NEW EPISODES
    • 23m AVG DURATION
    • 101 EPISODES


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    Latest episodes from Neuro-Oncology: The Podcast

    The proteomic landscape of diffuse midline glioma

    Play Episode Listen Later May 17, 2025 16:55


    Dr. Iyad Alnahhas interviews Drs. Cynthia Hawkins and Arun Vadivel about their recent manuscript entitled: "The proteomic landscape of diffuse midline glioma highlights the therapeutic potential of non-histone protein methyltransferases", published online in Neuro-Oncology in February 2025.   More Information

    Radio-Pathomic maps and MR perfusion

    Play Episode Listen Later Apr 18, 2025 20:25


    Dr. Iyad Alnahhas interviews Dr. Peter LaViolette about his and his team's recent manuscript entitled: "Multi-Site Retrospective Analysis of Diffusion and Perfusion MRI Correlates to Glioma Characteristics Derived from Radio-Pathomic Maps", published online in Neuro-Oncology in February 2025.

    CSF proteomics in glioma

    Play Episode Listen Later Mar 21, 2025 44:15


    Description: Dr. Evan Noch interviews Drs. Cecile Riviere-Cazaux and Terry Burns about their recent manuscript entitled: "A field resource for the glioma cerebrospinal fluid proteome: impacts of resection and location on biomarker discovery", published online in Neuro-Oncology in December 2024.   Link: https://doi.org/10.1093/neuonc/noae277  

    Vorasidenib in IDH mutant glioma

    Play Episode Listen Later Mar 8, 2025 42:44


    Description: Dr. Ankush Bhatia interviews Drs. Macarena de la Fuente and Mehdi Touat about their recent manuscript entitled: "The role of vorasidenib in the treatment of isocitrate dehydrogenase-mutant glioma" published online in Neuro-Oncology in December 2024.   Link: https://doi.org/10.1093/neuonc/noae259

    KL-50 in post TMZ MMR-deficient GBM

    Play Episode Listen Later Feb 22, 2025 21:33


    Dr. Iyad Alnahhas interviews Dr. Craig Horbinski about his and his team's recent manuscript entitled "The novel DNA cross-linking agent KL-50 is active against patient-derived models of new and recurrent post-temozolomide mismatch repair-deficient glioblastoma", published online in Neuro-Oncology in December 2024.

    Measurable disease per FET-PET vs MRI in GBM

    Play Episode Listen Later Feb 8, 2025 14:06


    Dr. Iyad Alnahhas interviews Dr. Nathalie Albert about her and her team's recent manuscript entitled: "Measurable disease as baseline criterion for response in glioblastoma: A comparison of PET-based (PET RANO 1.0) and MRI-based (RANO) assessments", published online in Neuro-Oncology in January 2025.

    Pre-radiation chemotherapy in GBM

    Play Episode Listen Later Jan 20, 2025 13:42


    Dr. Iyad Alnahhas interviews Dr. Danielle Bazer about her and her team's recently published manuscript, entitled: Using a Pre-Radiation Window to Identify Potentially Active Cytotoxic Agents in Adults with Newly Diagnosed Glioblastoma", published online in Neuro-Oncology in November 2024.

    cIMPACT-NOW Update 8: grading of meningiomas

    Play Episode Listen Later Dec 13, 2024 43:16


    Dr. Rachna Malani interviews Drs. Felix Sahm and Arie Perry about their recent manuscript entitled: "cIMPACT-NOW Update 8: Clarifications on molecular risk parameters and recommendations for WHO grading of meningiomas", published online in Neuro-Oncology in August 2024   Read More

    Residual tumor volume and survival after CCNU/TMZ in GBM

    Play Episode Listen Later Nov 24, 2024 13:18


    Dr. Iyad Alnahhas interviews Drs. Thomas Zeyen and Johannes Weller about their recent manuscript entitled: "Quantitative assessment of residual tumor is a strong and independent predictor of survival in methylated glioblastoma following radiochemotherapy with CCNU/TMZ", published online in Neuro-Oncology in October 2024.

    Alterations in RNA splicing between meningioma DNA methylation groups

    Play Episode Listen Later Nov 8, 2024 33:46


    Dr. Evan Noch interviews Drs. Nathan Leclair, David Raleigh and Olga Anczukow about their recent manuscript entitled: "RNA splicing as a biomarker and phenotypic driver of meningioma DNA methylation groups", published online in Neuro-Oncology in August 2024.  

    The immune landscape of IDH mutant and IDHwt glioma

    Play Episode Listen Later Oct 25, 2024 33:27


    Dr. Evan Noch interviews Drs. Pravesh Gupta and Krishna Bhat about their recent manuscript entitled "Immune landscape of isocitrate dehydrogenase-stratified primary and recurrent human gliomas", published online in Neuro-Oncology in August 2024 Read Paper

    Equity-driven applications of AI in neuro-oncology

    Play Episode Listen Later Oct 9, 2024 22:34


    Dr. Iyad Alnahhas interviews Dr. Mulki Mehari about her and her team's recent manuscript entitled: "Enhancing neuro-oncology care through equity-driven applications of artificial intelligence", published online in Neuro-Oncology in August 2024.

    IDH mutant glioma across age groups

    Play Episode Listen Later Sep 20, 2024 34:34


    Dr. Maya Graham interviews Drs. Mary Jane Lim-Fat and Kee Kiat Yeo about their recent manuscript entitled "A comparative analysis of IDH-mutant glioma in pediatric, young adult, and older adult patients", published online in Neuro-Oncology in July 2024. Link: https://doi.org/10.1093/neuonc/noae142

    Contemporary molecular prognostic signatures in glioma

    Play Episode Listen Later Aug 30, 2024 20:00


    Dr. Iyad Alnahhas interviews Dr. Linda Bi, Hia Ghosh and Ruchit Patel about their recent manuscript entitled: "Contemporary Prognostic Signatures and Refined Risk Stratification of Gliomas: An Analysis of 4400 Tumors", published online in Neuro-Oncology in August 2024. More Information: https://academic.oup.com/neuro-oncology/advance-article/doi/10.1093/neuonc/noae164/7737688

    FDG PET in PCNSL

    Play Episode Listen Later Aug 9, 2024 9:36


    Dr. Iyad Alnahhas interviews Drs. Minyoung Oh and Hyungwoo Cho about their recent manuscript entitled: "Enhancing Prognostication and Treatment Response Evaluation in Primary CNS Lymphoma with 18F-FDG PET/CT", published online in Neuro-Oncology in August 2024.   Link to manuscript

    TMZ and MGMT in elderly GBM patients

    Play Episode Listen Later Jul 12, 2024 17:46


    Dr. Jasmin Jo interviews Dr. Monika Hegi about her and her team's recent manuscript entitled: "No benefit from TMZ treatment in GB with truly unmethylated MGMT promoter: Reanalysis of the CE.6 and the pooled Nordic/NOA-08 trials in elderly GB patients", published online in Neuro-Oncology in (I will fill in through Libsyn)

    IDH mutant glioma and IDH inhibitors

    Play Episode Listen Later Jul 5, 2024 24:11


    Dr. Maya Graham interviews Dr. Martin van den Bent about his and his team's recent review article entitled "The biological significance of age, enhancement, extent of resection and tumor grade in IDH mutant gliomas: how should they inform treatment decision in the era of IDH inhibitors? Invited review", published online in Neuro-Oncology in

    Leptomeningeal disease, a SNO and ASCO review

    Play Episode Listen Later Jun 28, 2024 38:03


     Dr. John Fortunato interviews Dr. Adrienne Boirre about her and her team's recent manuscript entitled "Leptomeningeal metastases from solid tumors: A SNO and ASCO consensus review on clinical management and future directions", published online in Neuro-Oncology on 

    Cancer stems cell in GBM

    Play Episode Listen Later Jun 21, 2024 31:27


    Dr. Iyad Alnahhas interviews Drs. Justin Lathia and Marco Gallo about their recent manuscript entitled "Cancer stem cell hypothesis 2.0 in glioblastoma: where are we now and where are we going?", published online in Neuro-Oncology in May 2024.

    Drug delivery across the blood-brain barrier

    Play Episode Listen Later Jun 13, 2024 23:19


    Dr. Ankush Bhatia interviews Dr. Keaton Piper about his and his team's manuscript, entitled "Consensus Review on Strategies to Improve Delivery Across the BBB Including Focused Ultrasound", published online in Neuro-Oncology in May 2024 Read Paper

    Gliomatosis cerebri in children

    Play Episode Listen Later May 24, 2024 42:45


    Dr. Evan Noch interviews Dr. Gunther Nussbaumer about his recent paper entitled: "Gliomatosis cerebri in children: a poor prognostic phenotype of diffuse gliomas with a distinct molecular profile" published online in Neuro-Oncology in May 2024.

    Immunotherapy drives mesenchymal shift in GBM

    Play Episode Listen Later May 17, 2024 24:18


    Dr. Maya Graham interviews Drs. Josephine Hendriksen and Joachim Weischenfeldt about their recent manuscript, "Immunotherapy drives mesenchymal tumour cell state shift and TME immune response in glioblastoma patients," published online in Neuro-Oncology in May 2024.

    Long-term outcomes of pediatric patients with optic pathway glioma

    Play Episode Listen Later May 4, 2024 15:11


    Dr. Iyad Alnahhas interviews Drs. Alice Morin, Samuel Abbou and Brice Fresneau about their recent manuscript entitled "Very long-term outcomes of pediatric patients treated for optic pathway gliomas: a longitudinal cohort study" published online in Neuro-Oncology in March 2024. Read Paper

    NF1 mutation and neuronal hyperexcitability

    Play Episode Listen Later Apr 12, 2024 22:56


    Postoperative cerebellar mutism

    Play Episode Listen Later Apr 5, 2024 32:20


    Dr. Rachna Malani interviews Dr. Hrishikesh Suresh about his and his team's recent manuscript entitled "Postoperative cerebellar mutism syndrome is an acquired Autism-like network disturbance", published online in Neuro-Oncology in December 2023. Read the paper

    Cell cycle checkpoints and alkylating agents

    Play Episode Listen Later Mar 22, 2024 18:20


    Dr. Evan Noch interviews Dr. Chunzhang Yang about his and his team's recent manuscript entitled "Abrogation of the G2/M checkpoint as a chemo sensitization approach for alkylating agents" published online in Neuro-Oncology in December 2023 Read Paper

    Liquid biopsy in CNS lymphoma

    Play Episode Listen Later Mar 15, 2024 21:29


    Dr. Iyad Alnahhas interviews Dr. Ricardo Soffietti about the recent RANO review entitled "Liquid biopsy for improving diagnosis and monitoring of CNS lymphomas: a RANO review" published online in Neuro-Oncology in March 2024.

    Immunotherapy for glioblastoma, lessons learned

    Play Episode Listen Later Mar 8, 2024 29:55


    Dr. John Fortunato interviews Dr. Antonio Chiocca about his and his team's recent manuscript entitled "Lessons learned from phase 3 trials of immunotherapy for glioblastoma: time for longitudinal sampling?" published online in Neuro-Oncology in February 2024. Get paper.

    TERTp mutation clonality in glioma

    Play Episode Listen Later Feb 27, 2024 33:22


    Dr. Maya Graham interviews Dr. Joseph Costello about his and his team's recent manuscript entitled "Whole tumor analysis reveals early origin of the TERT promoter mutation and intracellular heterogeneity in TERT expression", published online in Neuro-Oncology in December 2023.

    Liquid biopsy in H3K27M glioma

    Play Episode Listen Later Feb 9, 2024 27:20


    Description: Dr. Maya Graham interviews Dr. Carl Koschmann about his and his team's recent manuscript entitled: "Liquid biopsy in H3K27M diffuse midline glioma", published online in Neuro-Oncology in December 2023. Download PDF

    Glioma genetic profiles and electrophysiologic hyperexcitability

    Play Episode Listen Later Jan 26, 2024 22:29


    Dr. Iyad Alnahhas interviews Dr. Steven Tobochnik about his and his team's recent manuscript entitled "Glioma genetic profiles associated with electrophysiologic hyperexcitability", published online in Neuro-Oncology in Sep 2023. Read paper

    Epidemiology of glioma in Belgium

    Play Episode Listen Later Jan 12, 2024 13:17


    Dr. Jasmin Jo interviews Dr. Harry Pinson about his and his team's recent manuscript entitled: "Epidemiology and survival of adult-type diffuse glioma in Belgium during the molecular era" Read Paper

    The Biology of H3K27M Mutant Gliomas

    Play Episode Listen Later Dec 23, 2023 14:37


    Dr. Iyad Alnahhas interviews Dr. Amanda Saratsis about her recent manuscript entitled: "H3K27M Mutant Glioma: Disease Definition and Biological Underpinnings", published online in Neuro-Oncology in October 2023. Read Paper

    3D tumor volume assessment in PCNSL

    Play Episode Listen Later Dec 1, 2023 27:36


    Dr. Rachna Malani interviews Dr. Florian Scherer about his and his team's recent manuscript entitled: "Improved early outcome prediction by MRI-based 3D tumor volume assessment in patients with CNS lymphomas", published online in Neuro-Oncology in Sep 2023.   Link: https://pubmed.ncbi.nlm.nih.gov/37713267/

    Brain-tumor related epilepsy; a SNO consensus review

    Play Episode Listen Later Nov 17, 2023 26:55


    Dr. John Fortunato interviews Drs. Edward Avila and Steven Tobochnik about their recent manuscript entitled: "Brain tumor-related epilepsy management: A society for neuro-oncology consensus review on current management", published online in Neuro-Oncology in June 2023.   Read Paper

    Vorasidenib and grading of IDH mutant astrocytoma

    Play Episode Listen Later Oct 27, 2023 24:11


    Description: Dr. Ankush Bhatia interviews Dr. Matthias Preusser about the recent letter in Neuro-Oncology, entitled: "What is an isocitrate dehydrogenase-mutated central nervous system World Health Organization grade 2 glioma, or who should receive vorasidenib?", published in July 2023.

    Insulin feedback and PI3K inhibition in GBM

    Play Episode Listen Later Oct 6, 2023 25:07


    Description: Dr. Maya Graham interviews Dr. Evan Noch about his and his team's recent manuscript entitled: "Insulin feedback is a targetable resistance mechanism of PI3K inhibition in glioblastoma", published online in Neuro-Oncology in July 2023. Read Paper

    SOX10 indel mutations in schwannomas

    Play Episode Listen Later Sep 22, 2023 28:50


    Dr. Evan Noch interviews Dr. David Solomon about his and his team's recent manuscript entitled: "Novel SOX10 indel mutations drive schwannomas through impaired transactivation of myelination gene programs", published online in Neuro-Oncology in July 2023.   Read Paper

    Dendritic cell vaccines in gliomas

    Play Episode Listen Later Sep 8, 2023 17:22


    Dr. Iyad Alnahhas interviews Drs. Kelly Hotchkiss and Mustafa Khasraw about their recently published review entitled: "Dendritic cell vaccine trials in gliomas: untangling the lines", published online in Neuro-Oncology in June 2023. Read Paper

    Intrathecal trastuzumab for leptomeningeal metastases

    Play Episode Listen Later Aug 11, 2023 21:05


    Dr. Iyad Alnahhas interviews Drs. Priya Kumthekar and Jeffrey Raizer about their recent manuscript entitled: A phase I/II study of intrathecal trastuzumab in human epidermal growth factor receptor 2-positive (HER2- positive) cancer with leptomeningeal metastases: Safety, efficacy, and cerebrospinal fluid pharmacokinetics", published online in Neuro-Oncology in March 2023.

    Short term topiramate for radiation induced cytotoxic edema

    Play Episode Listen Later Jul 21, 2023 14:10


    Dr. Iyad Alnahhas interviews Drs. Maria Jose Contreras-Zarate and Diana Cittelly about their recent manuscript entitled: "Short-term topiramate treatment prevents radiation-induced cytotoxic edema in preclinical models of breast-cancer brain metastasis", published online in Neuro-Oncology in April 2023. Read Paper

    Venous thromboembolism in gliomas

    Play Episode Listen Later Jul 8, 2023 28:25


    Description: Dr. Maya Graham interviews Drs. Jasmin Jo, Craig Horbinski and David Schiff about their recent manuscript entitled: "Epidemiology, biology and management of venous thromboembolism in gliomas: an interdisciplinary review", published online in Neuro-Oncology in April 2023. Read Paper

    RANO resect

    Play Episode Listen Later Jun 23, 2023 20:08


    Dr. Iyad Alnahhas interviews Dr. Philipp Karschnia about his and his team's recent manuscript entitled "Prognostic validation of a new classification system for extent of resection in glioblastoma: A report of the RANO resect group", published online in Neuro-Oncology in May 2023. 

    Methylation profiling of adult ependymoma

    Play Episode Listen Later Jun 9, 2023 18:18


    Dr. Evan Noch interviews Dr. David Kaul about his and his team's recent manuscript entitled: "Adult intracranial ependymoma—relevance of DNA methylation profiling for diagnosis, prognosis, and treatment", published online in Neuro-Oncology in February 2023. Read Paper

    Pseudoprogression in IDH-mutant high-grade gliomas

    Play Episode Listen Later May 12, 2023 25:32


    Dr. Ankush Bhatia interviews Dr.François Ducray about his and his team's recent manuscript entitled:"Incidence and characteristics of pseudoprogression in IDH-mutant high-grade gliomas: A POLA network study", published online in Neuro-Oncology in March 2023.  

    Changes in survival outcomes in melanoma patients with brain metastases

    Play Episode Listen Later Apr 21, 2023 19:35


    Dr. Iyad Alnahhas interviews Drs. Sherise Ferguson and Michael Davies about their recent manuscript entitled: "Changes in Outcomes and Factors Associated with Survival in Melanoma Patients with Brain Metastases", published online in Neuro-Oncology in December 2022.   Read Paper

    Radiation therapy and structural brain changes

    Play Episode Listen Later Apr 7, 2023 23:32


    Dr. Evan Noch interviews Drs. Nikhil Rammohan and Kathleen Bandt about their recent manuscript entitled "Whole-brain radiotherapy associated with structural changes resembling aging as determined by anatomic surface-based deep learning", published online in Neuro-Oncology in February 2023. Read Paper

    Objective response rate targets for recurrent glioblastoma clinical trials

    Play Episode Listen Later Mar 17, 2023 31:36


    Dr. Maya Graham interviews Drs. Benjamin Ellingston and Timothy Cloughesy about their recently published manuscript entitled: "Objective response rate (ORR) targets for recurrent glioblastoma clinical trials based on the historic association between ORR and median overall survival", published online in Neuro-Oncology in January 2023.   Read Paper

    Mitotic count prognostic significance in IDH-mutant astrocytoma in the molecular era

    Play Episode Listen Later Mar 3, 2023 12:33


    Dr. Iyad Alnahhas interviews Dr. Max Kros about his and his team's recent manuscript entitled: "Mitotic count is prognostic in IDH-mutant astrocytoma without homozygous deletion of CDKN2A/B. Results of consensus panel review of EORTC trials 26053 and EORTC 22033-26033", published online in Neuro-Oncology in December 2022.   Read Paper

    Palliative care in neuro-oncology

    Play Episode Listen Later Feb 10, 2023 30:56


    Dr. Iyad Alnahhas interviews Drs. Tobias Walbert and Johan Koekkoek about their recent manuscript entitled "Palliative care and end-of-life care in adults with malignant brain tumors", published online in Neuro-Oncology in October 2022 Read Paper

    Nivolumab in MGMT methylated GBM

    Play Episode Listen Later Jan 27, 2023 20:04


    Description: Dr. Jasmin Jo interviews Dr. Michael Lim about his and his team's recent manuscript entitled: "Phase III trial of chemoradiotherapy with temozolomide plus nivolumab or placebo for newly diagnosed glioblastoma with methylated MGMT promoter", published online in Neuro-Oncology in November 2022.

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