Podcasts about Nature Communications

Semaglutide Slows Biological Aging A randomized, placebo-controlled study published in Nature Communications found semaglutide slowed biological aging markers by nine percent on the DunedinPACE epigenetic clock in adults living with HIV-associated metabolic disease, with simultaneous improvements across inflammation, heart, kidney, liver, and brain markers. Host Dave Asprey breaks down why this isn't a weight loss story. It's a metabolic inflammation story. He explains why the GLP-1 mechanism hitting insulin signaling, oxidative stress, and inflammatory pathways simultaneously is the real finding, and makes the case that your metabolic markers and your aging markers are the same numbers. Sources: https://www.medicalnewstoday.com/articles/glp-1-drugs-ozempic-wegovy-may-slow-biological-aging https://www.nature.com/articles/s41467-026-72861-3 https://today.ucsd.edu/story/study-popular-glp-1-drug-may-slow-down-biological-aging FDA Approves First New Sunscreen Ingredient in 20 Years The FDA approved bemotrizinol as a permitted OTC sunscreen active ingredient, the first new approval in roughly two decades, clearing it for adults and children six months and older with broad UVA and UVB coverage and low skin absorption. Host Dave Asprey explains why twenty years of regulatory lag left American consumers with inferior chemistry while Europe moved on, why he's watching independent absorption data before updating his own stack, and why consistency of use matters more than perfect formulation when sun protection remains one of the most evidence-backed longevity interventions available. Sources: https://www.fda.gov/news-events/fda-newsroom/press-announcements/fda-expands-sunscreen-options-first-time-20-years https://www.accessdata.fda.gov/scripts/cder/omuf/index.cfm?event=OrderDetail&orderid=OTC000039 https://www.usatoday.com/story/news/health/2026/06/09/new-sunscreen-ingredient-bemotrizinol/90477659007/ Deoxyribose Gel Matches Minoxidil in Hair Regrowth Study Researchers testing a topical gel made from deoxyribose, the sugar backbone of DNA, saw roughly 80 to 90 percent hair regrowth in a mouse model of male-pattern baldness, matching minoxidil results and showing new follicle formation and increased blood vessel activity in treated areas. Host Dave Asprey breaks down why mouse hair regrowth studies have a long history of failing to translate to humans, what a plausible circulation-based mechanism would actually need to show in human trial data before it's worth acting on, and why the molecule itself is interesting enough to keep watching. Sources: https://www.reddit.com/r/Biohackers/comments/1tyt87w/researchers_found_that_a_gel_made_from/ https://www.sciencealert.com/surprise-hair-loss-breakthrough-a-dna-sugar-gel-sparks-robust-regrowth Caffeinated Chewing Gum and Exercise Performance A systematic review and meta-analysis of 21 studies found caffeinated chewing gum produces a small but real ergogenic effect for muscular strength and countermovement jump height, with buccal absorption delivering caffeine faster than capsules or drinks in a five to twenty-five minute pre-training window. Host Dave Asprey breaks down why delivery mechanism is an underrated variable in caffeine optimization, why timing matters as much as dose, and why a modest but measurable edge on a cheap and accessible tool is exactly the kind of practical biohack worth understanding. Sources: https://pubmed.ncbi.nlm.nih.gov/42228847/ https://doi.org/10.1519/JSC.0000000000005530 https://www.reddit.com/r/Biohackers/comments/1u0acgc/fastacting_caffeine_does_caffeinated_chewing_gum/ Vitamin A Overdoses Surge Nearly 40 Percent Medical News Today reported a 38.7 percent spike in vitamin A overdoses in early 2025, driven by online misinformation claiming high-dose vitamin A treats or prevents measles, a claim with no clinical support and real toxicity risk from fat-soluble accumulation in the liver. Host Dave Asprey explains the actual hepatotoxicity and bone demineralization risks of preformed retinol excess, draws the critical distinction between preformed retinol and beta-carotene that got lost in the misinformation cycle, and makes the case that mechanism is not a dosing protocol and confusing the two is how people get hurt. Sources: https://www.medicalnewstoday.com/amp/articles/vitamin-a-overdoses-rose-by-38-7-2025-how-to-get-right-amount World Cup 2026 and Mass Gathering Health Risk With the 2026 FIFA World Cup underway, public health researchers are flagging dense international crowds, high-volume travel, and shared indoor and outdoor spaces as an elevated transmission environment for respiratory illness. Host Dave Asprey reframes the conversation away from germ exposure and toward immune terrain, explains why your resilience going into a high-contact environment is a variable you actually control, and lays out the pre-exposure preparation window that matters most for anyone traveling or attending large events this summer. Sources: https://www.healthline.com/health-news/2026-fifa-world-cup-health-risks-protect-yourself This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on GLP-1 aging biology, sunscreen chemistry and regulatory science, emerging hair regrowth research, caffeine delivery optimization, supplement toxicity risk, and immune terrain preparation for mass gathering events. Host Dave Asprey connects randomized clinical data, epigenetic clock research, consumer health regulation, and real-world optimization protocols into actionable frameworks for extending healthspan, sharpening performance, and staying ahead of the science. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: semaglutide biological aging, GLP-1 epigenetic clock, DunedinPACE aging marker, PCGrimAge mortality risk, bemotrizinol FDA approval, new sunscreen ingredient 2026, UVA UVB broad spectrum sunscreen, deoxyribose hair gel, minoxidil alternative hair regrowth, caffeinated chewing gum performance, buccal caffeine absorption, pre-workout caffeine timing, vitamin A overdose toxicity, preformed retinol hypervitaminosis, fat-soluble vitamin accumulation, World Cup 2026 health risk, immune terrain optimization, mass gathering respiratory illness, biohacking news 2026, longevity research, Dave Asprey, The Human Upgrade Thank you to our sponsors! - Viome | Check it out at viome.com and use code 10DAVE for 10% off. It's time to stop guessing and start knowing your body. - Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com. - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Resources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Intro 00:41 – Story 1: Ozempic Slows Aging Clocks 01:53 – Story 2: New Sunscreen Approved 03:12 – Story 3: DNA Sugar & Hair Regrowth 04:38 – Story 4: Caffeine Gum & Performance 06:13 – Story 5: Vitamin A Overdose Spike 07:59 – Story 6: World Cup & Immune Prep 09:34 – Outro See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Wednesday, June 10, 2026 - Week 24   #NightOfImpact was 15 Days ago! Photos: https://jeaniehorton.pixieset.com/curesyngap1nightofimpact2026/ Impact: $800k+, of which $300 was our match.  Industry: Multiple Academics & Clinicians: Stanford, Berkeley & UCSF.  Cross-pollination is always good. Speakers: Ash, John, Kathryn, Helen Willsey & Me.  Only got a video of John, which was a mistake. If you took one, please share.  Here is John: https://www.linkedin.com/posts/graglia_still-reflecting-on-our-inaugural-cure-syngap1-ugcPost-7467439971294048256-cUf9/    Dr. Willsey Rocks. Willsey Press Release https://www.eurekalert.org/news-releases/1130924 (both were at NoI). A few other points on HRW, as we call her.  Simons: https://curesyngap1.org/blog/future-research-for-syngap1-how-helen-willsey-broke-new-ground-frogs-in-hand/ Willsey in Neuron 2021: https://www.cell.com/neuron/pdf/S0896-6273(21)00002-7.pdf (Frogs) Birtele in Nature Neuroscience 2023: https://www.nature.com/articles/s41593-023-01477-3 (Confirms) McCluskey in Nature Communications 2025: https://www.nature.com/articles/s41467-025-57342-3 (GI) Kostyanovskaya in BioRxiv 2025: https://pubmed.ncbi.nlm.nih.gov/39677731 (cilium)   5TH SCRAMBLE FOR SYNGAP, SC – 114 days Classic case of a small event becoming an institution! cureSYNGAP1.org/Scramble26   CURE SYNGAP1 CONFERENCE - 175 days cureSYNGAP1.org/Pre    USA: use your ICD-10, F78.A1: https://onlinelibrary.wiley.com/doi/10.1002/epi.70142   PUBMED Pubmed 2026 is at 35. +11 vs the week. (61 last year was +9) https://pubmed.ncbi.nlm.nih.gov/?term=syngap1&filter=years.2026-2026&sort=date   SOCIAL MATTERS 5,045 LinkedIn.  https://www.linkedin.com/company/curesyngap1 1.58k YouTube.  https://www.youtube.com/@CureSYNGAP1 11.1k Twitter https://twitter.com/cureSYNGAP1 45k Insta https://www.instagram.com/curesyngap1   $CAMP closed at $4.34 today. https://www.google.com/finance/beta/quote/CAMP:NASDAQ   Like and subscribe to this podcast wherever you listen. https://curesyngap1.org/podcasts/syngap10 Episode 209 of #Syngap10 #SYNGAP1 #CureSYNGAP1 #Podcast #PatientAdvocacy

Summary: Hidradenitis Suppurativa (HS) is one of dermatology's most complex and underrecognized conditions and the treatment landscape is changing fast. In this episode, Dr. Faranak Kamangar sits down with Dr. Hadar Lev-tov, Associate Professor at the University of Miami, Director of the Wound Healing Fellowship, and Immediate Past President of the Hidradenitis Suppurativa Foundation, for a rapid-fire review of everything happening in the HS world right now. Dr. Lev-tov covers the currently approved therapies, the exciting drugs moving through Phase 3 trials, and the groundbreaking science linking microplastics to HS inflammation. He also shares his candid take on GLP-1s in HS management and what the future of dermatology looks like when treatments work so well that doctors can finally focus on the whole patient. Whether you're a resident just learning HS or a seasoned dermatologist trying to keep up with a fire-hose pipeline, this one is for you. Topics Covered: - Approved HS biologics: bimekizumab, secukinumab, adalimumab & biosimilars - Off-label use of infliximab (IV and subcutaneous) in severe HS - Phase 3 pipeline: remibrutinib, povorcitinib, sonelokimab (nanobodies) - CAR T-cell therapy and the possibility of curing inflammatory skin disease - Microplastics, nicastrin, and a landmark Nature Communications paper on HS - GLP-1s in HS: what we know, what we don't, and Dr. Levtov's clinical approach - The HS Foundation's research grants, HS Academy, wound care referral tool, and prior authorization templates - The future of dermatology as lifestyle medicine Resources Mentioned: - https://www.nature.com/articles/s41467-025-65789-7  - HS Foundation website & prior authorization templates: https://www.hs-foundation.org/ - HS Academy (free weekend for residents): https://www.hs-foundation.org/hs-academy - Integrative Dermatology Symposium: integrativedermatologysymposium.com - LearnSkin: learnskin.com This podcast is for educational purposes only and is not a substitute for professional medical advice. Always consult your healthcare provider. Key Takeaways: 1. Validate HS patients the moment they walk in. They've often been dismissed or bounced between providers for years. Simply saying "I understand what you're going through" builds trust immediately and makes the visit more productive. 2. The approved HS treatment arsenal is growing. Bimekizumab and secukinumab (IL-17 inhibitors) are now approved, and adalimumab — including biosimilars — remains a valuable option. Clinical experts are using biosimilars with confidence. 3. Subcutaneous infliximab is an emerging option. Available off-label in the US, new data from French centers shows a protocol: standard IV induction at weeks 0, 2, and 6, then switching to subcutaneous injections every two weeks at week 10 — but only once the patient is in strong remission. 4. Three major drugs are in or completing Phase 3 trials. Remibrutinib (BTK inhibitor, already approved for chronic spontaneous urticaria), povorcitinib (JAK1 inhibitor), and sonelokimab (a nanobody targeting IL-17A and IL-17F) are all reporting promising results and moving toward FDA application. 5. Nanobodies are a technology to watch. Derived from camelid antibody fragments, nanobodies like sonelokimab can be engineered to target multiple pathways simultaneously in a smaller, more modular molecule — expect to see them across dermatology. 6. Half-life extenders could mean one injection per year. Already emerging in psoriasis, these extended-dosing biologics are heading toward HS — a potential game-changer for patient adherence. 7. CAR T-cell therapy may one day cure inflammatory skin disease. Currently being studied in lupus and rheumatoid arthritis, the protocols are becoming more practical, and the technology is edging toward dermatology. 8. Microplastics may potentiate HS inflammation. A Nature Communications paper by Dr. Luis Garza (Hopkins) found that plastic-associated endocrine disruptors block nicastrin in fibroblasts, amplifying HS-related inflammation. This doesn't prove causation, but it reveals a meaningful environmental link — and highlights the underappreciated role of fibroblasts in HS scarring. 9. GLP-1s in HS: promising but not proven as monotherapy. There's no RCT yet. Dr. Levtov's clinical approach: stabilize HS with a biologic first, then consider adding a GLP-1 as part of a comprehensive plan that includes diet and resistance training. He has seen outcomes go both ways. 10. The HS Foundation is an underutilized resource. Their website offers a clinic finder, wound care referral service, prior authorization templates (one-click Word documents), research grants, the HS Academy (free, all-expenses-paid weekend for residents), and career development awards in partnership with the Dermatology Foundation. Chapters: 0:00 – Introduction & Dr. Lev-tov's Background 0:49 – The #1 Clinical Tip for Seeing HS Patients 1:44 – Approved HS Treatments: IL-17 Inhibitors, Adalimumab & Biosimilars 2:40 – Off-Label Infliximab: IV and the New Subcutaneous Protocol 4:21 – Phase 3 Pipeline: Remibrutinib, Povorcitinib & Sonelokimab (Nanobodies) 6:00 – Half-Life Extenders & One-Injection-Per-Year Future 7:01 – CAR T-Cell Therapy: Could We Cure Inflammatory Skin Disease? 7:36 – Research Funding & HS Foundation Grants 8:43 – HS Foundation Tools: Prior Auth Templates, Clinic Finder & HS Academy 10:15 – Microplastics, Nicastrin & the Nature Communications Paper 13:22 – What This Means for Fibroblasts and HS Scarring 14:20 – Celebrating Dermatology Science & Clinician-Scientists 15:32 – GLP-1s & HS: What's the Evidence? 17:18 – Dr. Lev-tov's Clinical Approach to GLP-1 Requests 19:06 – The Future of Dermatology: Becoming Lifestyle Doctors 21:28 – The Integrative Dermatology Symposium & LearnSkin Certificate Program 22:50 – Closing Remarks

ReferencesCell Metabolism 2024. Volume 36, Issue 4p839-856.e8April 02,JNeurosci.2012Dec 5;32(49):17909–17920.JACC Cardiovasc Interv. 2025 Apr 28;18(8):963-971Genes Dev. 2012 May 15;26(10):1070–1085.Nature Communications 2018. V 9, Article number: 1479 Guerra, DJ. 2026. Unpublished LecturesAnderson/Howe/Squire/Offord/Bruford/Wakeman. 1972.. You and I. Yeshttps://music.youtube.com/watch?v=HfssvCECiaA&si=48Gs_iJC5x3t8evF

Fresh Pressed Olive Oil Club (buy 2 bottles, get 1 free for Ben's community): https://freshpressolive.com/3RBPwdG  Pre-order Ben's new book KetoFlex Revised — Pre-order now and get free bonus chapters:  https://bit.ly/4wKG1sM  Kidney disease doesn't start with pain. It starts with nothing. By the time you feel it, you may have already lost half your kidney function. The National Kidney Foundation reports 90% of people with chronic kidney disease don't know they have it. In most cases, the damage begins 10 to 15 years before any diagnosis — while labs still look normal. THE 7 HABITS Blood Sugar Spikes. Post-meal glucose spikes damage the hair-thin filtration vessels inside the kidneys over time. A 2024 Nature Communications paper found cellular insulin resistance drives kidney damage before diabetes ever appears. Chronic Dehydration. Your kidneys filter 180 liters of plasma daily. Less water means concentrated waste and a higher workload. Coffee, soda, and energy drinks don't count. Drink clean spring water. Processed Food. Phosphate additives and industrial seed oils (soybean, corn, canola) create ongoing inflammation in the blood vessels kidneys depend on. Swap to butter, ghee, tallow, coconut oil, and high-quality olive oil.  Sugar and Fructose. Fructose overwhelms the liver, converts to uric acid, and lands on the kidneys. A 2024 UK Biobank study of 127,000+ adults found even one sugar-sweetened beverage daily significantly raises kidney disease risk. Diet soda is not a safe swap. Ignoring Blood Pressure. No symptoms doesn't mean no damage. Every heartbeat sends pressure through delicate kidney capillaries. Damaged kidneys then lose their ability to regulate pressure — creating a worsening feedback loop. Chronic Stress and Poor Sleep. Cortisol raises blood sugar, blood pressure, and insulin resistance. Sleeping under four hours raises kidney disease risk by 45%. Kidney repair happens at night. Ignoring Insulin Resistance. The root of everything. By the time labs flag it, you've likely been insulin resistant for 6 to 14 years. About 93% of American adults have some form of it. Find All The Ben Azadi Show Sponsorship Deals ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.ketokamp.com/sponsorship-deals Learn more about your ad choices. Visit megaphone.fm/adchoices

This episode features Prof. Rihua Xie from Guangdong Medical University (China) and Dr. Yuhang Zhang from Peking University First Hospital (China), speaking about vaginal microbiota transfer (VMT) and how it may affect neurodevelopment in newborn infants born by Cesarean section. Compared with vaginally delivered infants, C-section delivered infants have altered microbial exposures. VMT has been proposed as a way to ‘restore' the microbiota of these infants to more closely resemble that of vaginally-born infants. A recent study by Prof. Xie and Dr. Zhang showed that the order and timing of early microbial colonization of the infant is important. They found that VMT could establish a vaginal-like skin microbiota in infants born by C-section, with two particular bacterial species that were higher after VMT. These two species led to the production of metabolites that combined on the newborn's skin to synthesize an important lipid, which was positively correlated with neurodevelopment scores at three and six months. Subsequent mouse model work showed how this lipid could reach the brain. In the future, safety and standardization of VMT will be important priorities in this research area. Prof. Xie and Dr. Zhang emphasized that their work needs to be replicated in larger cohorts, with the eventual goal of engineering bacteria to create a probiotic intervention that delivers neurodevelopmental benefits to C-section born infants. Episode abbreviations and links: The research by Prof. Xie and Dr. Zhang demonstrating how a VMT intervention alters the skin microbiota of newborns, with a mechanistic link to neurodevelopment: Vaginal microbiota transfer ameliorates cesarean-associated neurodevelopmental deficits in mice via N-bc2S1P synthesis on neonatal skin About Prof. Rihua Xie: Dr. Ri-hua Xie (RN, PhD, FAAN) is Professor, Principal Investigator, and Chief Nurse at the School of Nursing, Southern Medical University, and the Affiliated Foshan Women and Children Hospital, Guangdong Medical University, China. Dr. Xie is widely recognized for her expertise in maternal and infant health as a clinician, researcher, and supervisor. She has published more than 90 peer-reviewed papers and 11 nursing textbooks and has received 12 competitive research grants from institutions in China and Canada. In addition to her academic work, Dr. Xie is actively engaged in community and public health service, including breastfeeding promotion and frontline support during the COVID-19 pandemic. Her research focuses on perinatal epidemiology, maternal and child health, and microbiome science, with a particular emphasis on the effects of vaginal microbiota transfer (VMT) on the microbiota composition and health outcomes of cesarean-delivered infants. About Dr. Yuhang Zhang: Yuhang Zhang, PhD in Pharmacology, is an Associate Professor and Principal Investigator at Peking University First Hospital. He received his MD-PhD from Capital Medical University and was a visiting scholar at McGill University, Canada. Dr. Zhang's research focuses on gut microbiome, probiotics, and microbial metabolism in metabolic diseases, who has published over 20 peer‑reviewed papers as first or corresponding author in journals including Gastroenterology, Journal of Hepatology, and Nature Communications, cited >1,000 times. He has led 9 grants, including the National Natural Science Foundation of China, who was selected for the Beijing Association for Science and Technology Young Talent Program (2022) and the China Association for Science and Technology Young Talent Program (2025). The research of Dr. Zhang focuses on the integrated systems pharmacology, multiomics and microbiome‑host interactions to develop precision medicine.

Five longevity beliefs that millions have followed for decades have just been overturned by the latest research. Some of these will surprise you.In this explainer, Robert Lufkin MD walks through five of the most widely believed longevity myths — and what the most recent science actually says about each one. From genetics and middle age to antioxidants, alcohol, and caloric restriction, the evidence has shifted dramatically.CHAPTERS:00:00 — Introduction00:32 — Myth 1: Your Genes Determine How Long You Live01:51 — Myth 2: It's Too Late to Change After Middle Age03:24 — Myth 3: Antioxidant Supplements Prevent Disease05:22 — Myth 4: Moderate Alcohol Is Good for You07:04 — Myth 5: Caloric Restriction Is King08:50 — The Real Framework: Quality Beats Quantity09:18 — Final TakeawayKEY TAKEAWAYS:• Genetics accounts for at most 25–50% of how long you live• Quitting smoking before 40 eliminates ~90% of excess mortality risk• Antioxidant supplements have no benefit and may increase mortality• The protective J-curve for moderate alcohol disappears once you correct for the "sick quitter" effect• Caloric restriction's primate magic was rescuing animals from a high-sugar control diet• Diet quality matters more than diet quantitySTUDIES & SOURCES MENTIONED:• Herskind et al., Human Genetics 1996 — 2,872 Danish twin pairs heritability of longevity• Jha et al., NEJM 2013 — 21st-century smoking cessation and life expectancy• Saint-Maurice et al., JAMA Network Open 2019 — Adult life-course physical activity and mortality• Bjelakovic et al., Cochrane 2012 — Antioxidant supplements for prevention of mortality• Zhao et al., JAMA Network Open 2023 — Daily alcohol intake and all-cause mortality meta-analysis• Mattison et al., Nature Communications 2017 — Caloric restriction in rhesus monkeys (NIA / Wisconsin reconciliation)⭐ Enjoying the show? Please leave a 5-star review on Apple Podcasts — it takes 30 seconds and helps more people discover the science of health and longevity. Thank you!New episodes every Tuesday & Thursday. Subscribe so you don't miss one.Continue this conversation on Substack: https://robertlufkinmd.substack.comLies I Taught In Medical School — Free sample chapter: https://www.robertlufkinmd.com/lies/Web: https://www.robertlufkinmd.comYouTube: https://www.youtube.com/robertlufkinmdX: https://x.com/robertlufkinmdInstagram: https://www.instagram.com/robertlufkinmd/TikTok: https://www.tiktok.com/@robertlufkinLinkedIn: https://www.linkedin.com/in/robertlufkinmd/

Pendant longtemps, les chercheurs ont pensé que le surpoids, en général, augmentait le risque de déclin cognitif et de vieillissement du cerveau. Mais une nouvelle étude internationale pré-publiée dans Nature Communications apporte une vision beaucoup plus précise : ce ne serait pas tant le poids total qui poserait problème, mais l'emplacement exact de certaines graisses dans le corps.Les travaux ont été menés par des chercheurs de Université Ben-Gourion du Néguev, en collaboration avec Université Harvard, Université de Leipzig et Université Tulane. Leur conclusion est frappante : la graisse viscérale, c'est-à-dire celle qui s'accumule profondément autour des organes abdominaux, semble associée à une accélération du vieillissement cérébral.Contrairement à la graisse située juste sous la peau, la graisse viscérale est biologiquement très active. Elle ne sert pas seulement de réserve énergétique : elle produit aussi des molécules inflammatoires, des hormones et divers composés chimiques capables d'affecter l'ensemble du corps. Or, le cerveau est particulièrement sensible à l'inflammation chronique.Les chercheurs ont utilisé des techniques avancées d'imagerie médicale pour mesurer précisément la répartition des graisses chez les participants. Ils ont ensuite comparé ces données avec des marqueurs du vieillissement cérébral observés grâce à des IRM du cerveau. Résultat : les personnes présentant davantage de graisse viscérale montraient des signes plus importants de vieillissement du tissu cérébral, parfois même indépendamment de leur poids total.Autrement dit, deux personnes ayant le même indice de masse corporelle peuvent avoir des risques neurologiques très différents selon la manière dont leur graisse est répartie.Pourquoi cette graisse abdominale est-elle si problématique ? Plusieurs mécanismes sont envisagés. D'abord, elle favorise une inflammation de bas niveau mais permanente dans l'organisme. Ensuite, elle augmente les risques de diabète, d'hypertension et de troubles vasculaires, qui affectent directement les petits vaisseaux sanguins du cerveau. Enfin, certaines molécules produites par la graisse viscérale pourraient perturber directement le fonctionnement des neurones.Cette découverte pourrait modifier la manière dont les médecins évaluent les risques liés au vieillissement cérébral. Jusqu'ici, le poids ou l'IMC étaient souvent utilisés comme indicateurs principaux. Mais cette étude suggère qu'il faut regarder plus précisément où se situe la graisse.Le fameux “bourrelet abdominal” n'est donc pas seulement une question esthétique ou cardiovasculaire. Il pourrait aussi représenter un marqueur important de la santé du cerveau et de son vieillissement futur. Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

Pendant longtemps, les chercheurs ont pensé que le surpoids, en général, augmentait le risque de déclin cognitif et de vieillissement du cerveau. Mais une nouvelle étude internationale pré-publiée dans Nature Communications apporte une vision beaucoup plus précise : ce ne serait pas tant le poids total qui poserait problème, mais l'emplacement exact de certaines graisses dans le corps.Les travaux ont été menés par des chercheurs de Université Ben-Gourion du Néguev, en collaboration avec Université Harvard, Université de Leipzig et Université Tulane. Leur conclusion est frappante : la graisse viscérale, c'est-à-dire celle qui s'accumule profondément autour des organes abdominaux, semble associée à une accélération du vieillissement cérébral.Contrairement à la graisse située juste sous la peau, la graisse viscérale est biologiquement très active. Elle ne sert pas seulement de réserve énergétique : elle produit aussi des molécules inflammatoires, des hormones et divers composés chimiques capables d'affecter l'ensemble du corps. Or, le cerveau est particulièrement sensible à l'inflammation chronique.Les chercheurs ont utilisé des techniques avancées d'imagerie médicale pour mesurer précisément la répartition des graisses chez les participants. Ils ont ensuite comparé ces données avec des marqueurs du vieillissement cérébral observés grâce à des IRM du cerveau. Résultat : les personnes présentant davantage de graisse viscérale montraient des signes plus importants de vieillissement du tissu cérébral, parfois même indépendamment de leur poids total.Autrement dit, deux personnes ayant le même indice de masse corporelle peuvent avoir des risques neurologiques très différents selon la manière dont leur graisse est répartie.Pourquoi cette graisse abdominale est-elle si problématique ? Plusieurs mécanismes sont envisagés. D'abord, elle favorise une inflammation de bas niveau mais permanente dans l'organisme. Ensuite, elle augmente les risques de diabète, d'hypertension et de troubles vasculaires, qui affectent directement les petits vaisseaux sanguins du cerveau. Enfin, certaines molécules produites par la graisse viscérale pourraient perturber directement le fonctionnement des neurones.Cette découverte pourrait modifier la manière dont les médecins évaluent les risques liés au vieillissement cérébral. Jusqu'ici, le poids ou l'IMC étaient souvent utilisés comme indicateurs principaux. Mais cette étude suggère qu'il faut regarder plus précisément où se situe la graisse.Le fameux “bourrelet abdominal” n'est donc pas seulement une question esthétique ou cardiovasculaire. Il pourrait aussi représenter un marqueur important de la santé du cerveau et de son vieillissement futur. Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

In this episode, Ray Cochrane breaks down a reversible conductive glue from Newcastle University that could replace solder and finally make electronics recycling work. Additional stories cover China widening its clean energy lead, DeepMind’s AlphaEvolve scoring wins from genomics to Google’s database, Anthropic’s $200 million partnership with the Gates Foundation, Intel teaming up with McLaren Racing, and end-to-end encrypted RCS rolling out in beta. – Want to start a podcast? Its easy to get started! Sign-up at Blubrry – Thinking of buying a Starlink? Use my link to support the show. Subscribe to the Newsletter. Email Ray if you want to get in touch! Like and Follow Geek News Central’s Facebook Page. Support my Show Sponsor: Best Godaddy Promo Codes Get 1Password Full Summary Cochrane opens the show with a deep dive into Newcastle University’s reversible conductive glue, a water-based adhesive that could finally make electronics recycling economically viable. He frames the e-waste problem first: 62 billion kilos a year, with less than a quarter ever recycled. Then he walks through the silver nanoparticle chemistry, the lead-free angle on traditional solder, and the geopolitical stakes of critical mineral recovery. From there the episode pivots through energy, AI, hardware, open source, data research, space, science, and consumer privacy. A Reversible Conductive Glue That Could Replace Solder A team at Newcastle University has developed a water-based glue that conducts electricity well enough to replace solder. Unlike solder, however, the glue releases cleanly with a quick rinse of acetone or an alkaline bath. The breakthrough relies on silver nanoparticles suspended in a water-based binder. Consequently, components can be recovered intact, opening a viable path to electronics recycling at scale. Co-investigator Volker Pickert framed the second prize directly: solder has the best conductivity, but the best formulations contain lead. China Widens Its Clean Energy Lead A new Atlas Public Policy report shows Chinese firms accounted for 55 percent of $1.1 trillion in global clean energy manufacturing investment between 2019 and 2025. Battery manufacturing alone pulled in nearly half of that money. Meanwhile, U.S. companies have actively retreated from those same industries. With the Strait of Hormuz currently closed, supply chain ownership in solar, wind, and batteries matters more than ever. A separate Ember analysis showed Chinese solar panel exports doubled in March alone. DeepMind’s AlphaEvolve Scores Real Wins DeepMind published an update on AlphaEvolve, its Gemini-powered AI coding agent. The system cut genomic variant detection errors by 30 percent. Additionally, it lifted AC Optimal Power Flow feasibility from 14 to over 88 percent on the electrical grid. AlphaEvolve also found a better cache replacement policy in two days that would have taken human engineers months. Furthermore, it reduced write amplification in Google’s Spanner database by 20 percent. The pattern shows applied AI sticking, not as a chatbot but as a quiet optimizer. Anthropic and Gates Foundation Commit $200 Million Anthropic announced a four-year, $200 million partnership with the Gates Foundation across three pillars. The biggest pillar targets global health and life sciences in low and middle-income countries. Notably, the research scope includes polio, HPV, and preeclampsia. A second pillar covers AI in education across the U.S., sub-Saharan Africa, and India, in partnership with the Global AI for Learning Alliance. Finally, an economic mobility pillar focuses on agricultural productivity and crop benchmarks. Google’s AI Educator Series Launches Free Google rolled out the first 20-plus sessions of its AI Educator Series this week. The free AI literacy training targets the roughly 6 million K-12 and higher education teachers across the U.S. Modules are designed as short, snackable trainings teachers can finish in a prep period or a lunch break. Additionally, stackable workshops let educators build credentials over time. Importantly, the program requires no institutional subscription. Amazon Bedrock Prompt Optimization Goes GA Amazon Bedrock dropped its Advanced Prompt Optimization tool, now generally available across most major regions. The feature rewrites prompts to perform better on specific models and automates prompt migration when switching between models. Furthermore, a built-in evaluation feedback loop lets users benchmark against up to five models side by side. The default judge model is Claude Sonnet 4.6. Consequently, teams can stop hand-tuning string templates and focus on product work. Sponsor: GoDaddy Economy hosting $6.99/month, WordPress hosting $12.99/month, domains $11.99. Website builder trial available. Use codes at geeknewscentral.com/godaddy to support the show. Arm AGI CPU and Red Hat Go Production-Ready on Agentic AI Arm and Red Hat expanded their collaboration around Arm’s AGI CPU, which is Arm’s branding for its agentic AI chip family. The deal brings Red Hat Enterprise Linux and OpenShift to the chip as a production-ready stack. Hardware specifications include 136 Neoverse V3 cores, 96 PCIe Gen6 lanes, and 12 channels of DDR5-8800 memory in a 300-watt thermal envelope. Availability lands in Q4 through Supermicro, Lenovo, and ASRock Rack. Intel Becomes McLaren Racing’s Official Compute Partner Intel announced a multi-year deal as the official compute partner for McLaren Racing. The agreement covers the McLaren Mastercard Formula 1 team, Arrow McLaren IndyCar, and McLaren F1 Sim Racing. Trackside edge compute will power real-time race decisions, while Xeon and Core Ultra silicon drive Computational Fluid Dynamics and digital twin work. Consequently, design iterations that once took weeks now collapse to days. The deal puts Intel silicon in front of every CTO watching a Grand Prix. Rust Lands 13 Google Summer of Code Projects The Rust Project landed 13 accepted projects in Google Summer of Code 2026. Out of 96 proposals, a 50 percent jump from last year, the project selected 13. Notably, three returning contributors from prior years are back. Mentors flagged a noticeable share of AI-generated submissions as a growing challenge. Furthermore, the real bottleneck remains mentor capacity rather than funding. GitHub Innovation Graph Maps Digital Complexity Researchers used GitHub Innovation Graph data to predict GDP, inequality, and emissions through the Economic Complexity Index, or ECI. Countries are compared to kitchens; the more variety and sophistication in software output, the higher the score. Germany ranks first, followed by Australia and Canada. The U.S. lands at sixth. However, the dataset only captures public GitHub activity, leaving most proprietary software invisible. NASA and Eta Space Prepare Cryogenic Fuel Demo NASA is teaming with Eta Space on an in-orbit demonstration called LOXSAT, short for Liquid Oxygen Flight Demonstration. The nine-month mission tests cryogenic fluid management techniques required for in-space propellant depots. Launch is no earlier than July 17 aboard a Rocket Lab Electron from the Mahia Peninsula in New Zealand. Successful refueling in orbit could reshape what is possible for deep-space missions to the Moon and Mars. Stealth Magma Surge Under São Jorge Surprises Researchers Researchers in the UK and Spain published in Nature Communications on a 2022 magma surge under São Jorge Island in the Azores. The surge climbed from more than 20 kilometers underground to 1.6 kilometers below the surface. Surprisingly, most of the thousands of earthquakes happened after the magma stalled, not during the climb. Consequently, scientists are calling it a stealth surge and a failed eruption. A primed magma chamber now sits closer to the surface than before. End-to-End Encrypted RCS Begins Rolling Out Apple and Google led a cross-industry effort to roll out end-to-end encryption for RCS messaging. As of May 11, the feature is rolling out in beta on both platforms. Importantly, encryption is on by default and auto-applies to new and existing conversations. A lock icon in the chat indicates active end-to-end encryption. This quietly raises baseline privacy for billions of cross-platform messages. Cochrane signs off with the usual ecosystem mentions: GNC Insider at geeknewscentral.com/insider, the show newsletter, and modern podcast app recommendations at podcastapps.com. The post A Reversible Glue that could Replace Solder #1865 appeared first on Geek News Central.

In May 2024, the "Mother's Day Superstorm" slammed into Mars with a force Earth didn't experience. But how do we see a storm on a planet without a magnetic field? In this episode, we sit down with Dr. Jacob Parrott from the European Space Agency (ESA) to discuss his groundbreaking research recently published in Nature Communications. Jacob explains how he and his team "hacked" veteran satellites—the Mars Express and the ExoMars Trace Gas Orbiter—to perform an unintended dance known as "mutual radio occultation." Discover how redundant hardware from failed landers became a cutting-edge sensor for Martian aeronomy, revealing how solar flares strip the atmosphere from the Red Planet. In this episode: • From biology and media internships to ESA's grad scheme. • The physics of radio occultation: Using signal "bending" to measure atmospheric density. • Retasking the Melacom and Electra antennas for deep-space science. • Processing the data: From raw waveforms to Python and SPICE simulations. Read the full transcript and see the images at: https://www.Astrophiz.com

Par une chaude soirée d'été, il suffit d'allumer une lampe pour voir apparaître le même étrange ballet : des insectes tournent frénétiquement autour de la lumière, jusqu'à parfois s'y brûler les ailes. Papillons de nuit, moustiques ou scarabées semblent littéralement hypnotisés. Mais pourquoi les insectes foncent-ils dans la lumière ?Pendant longtemps, les scientifiques ont pensé connaître la réponse. L'explication classique reposait sur la navigation. De nombreux insectes nocturnes utilisent en effet les sources lumineuses naturelles, comme la Lune ou les étoiles, pour se repérer. Ces astres étant extrêmement éloignés, leur lumière arrive presque parallèlement sur Terre. Les insectes garderaient donc un angle constant avec cette lumière pour voler en ligne droite.Le problème, c'est qu'une ampoule ou une bougie se trouve tout près. Si l'insecte tente de conserver le même angle avec une source lumineuse proche, sa trajectoire se transforme en spirale. Résultat : il tourne autour de la lampe sans parvenir à s'en éloigner.Cette théorie était séduisante… mais incomplète. Car certaines observations ne collaient pas vraiment. Pourquoi certains insectes semblent-ils totalement perdre le contrôle de leur vol près d'une lumière artificielle ? Pourquoi se retournent-ils parfois brutalement ou plongent-ils directement vers l'ampoule ?En 2024, une étude très remarquée publiée dans la revue Nature Communications a apporté un nouvel éclairage sur ce mystère. Grâce à des caméras ultra-rapides, des chercheurs ont observé précisément le comportement d'insectes en vol autour de différentes sources lumineuses.Et ils ont découvert quelque chose d'étonnant : les insectes ne sont pas réellement “attirés” par la lumière. En réalité, ils sont désorientés.Leur cerveau utilise naturellement la lumière du ciel comme repère pour savoir où se trouve le haut. Dans la nature, le ciel est presque toujours plus lumineux que le sol. Les insectes ont donc évolué pour garder leur dos orienté vers la lumière afin de maintenir leur équilibre en vol.Mais une lampe artificielle bouleverse complètement ce système. Lorsqu'un insecte passe près d'une ampoule, il interprète cette lumière intense comme… le ciel. Il tente alors de réorienter son corps pour garder son dos face à la source lumineuse. Cela provoque des virages absurdes, des retournements et parfois une perte totale de contrôle.Autrement dit, l'insecte ne cherche pas la lumière : il essaie simplement de ne pas tomber.Cette découverte est importante car la pollution lumineuse représente aujourd'hui un immense problème écologique. Des milliards d'insectes meurent chaque année à cause des éclairages artificiels. Or les insectes jouent un rôle fondamental dans les écosystèmes : pollinisation, alimentation des oiseaux, recyclage des matières organiques…Les scientifiques recommandent donc de réduire les lumières inutiles la nuit, d'utiliser des éclairages moins agressifs et de privilégier certaines couleurs moins perturbantes pour les insectes.Car derrière ce petit ballet nocturne autour des lampes se cache en réalité un gigantesque piège créé par l'être humain. Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

Nadine Dijkstra is a Principal Investigator at the Institute of Neurology at UCL. Her research in Imaging Neuroscience explores how the brain generates mental images and differentiates them from actual perception. Utilizing neuroimaging, psychophysics, machine learning, and computational modeling, Dijkstra addresses fundamental questions about the overlap between perception and imagery.Recently, Dijkstra has been leading the Imagine Reality Lab at UCL's Department of Imaging Neuroscience, focusing on the intersection of imagination and reality. Dijkstra's 2023 paper in Nature Communications showed the brain evaluates images against a 'reality threshold' to distinguish between images and perception. Her work also investigates how changes in these neural processes could impact mental health.Check out our new series, Ideas for Our Time: https://youtu.be/nYS4FylZJ2QDon't hesitate to email us at podcast@iai.tv with your thoughts or questions on the episode!To witness such debates live buy tickets for our upcoming festival: https://howthelightgetsin.org/festivals/And visit our website for many more articles, videos, and podcasts like this one: https://iai.tv/You can find everything we referenced here: https://linktr.ee/philosophyforourtimesSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

If you enjoy this episode, we're sure you will enjoy more content like this on The Occult Rejects.  In fact, we have curated playlists on occult topics like grimoires, esoteric concepts and phenomena, occult history, analyzing true crime and cults with an occult lens, Para politics, and occultism in music. Whether you enjoy consuming your content visually or via audio, we've got you covered - and it will always be provided free of charge.  So, if you enjoy what we do and want to support our work of providing accessible, free content on various platforms, please consider making a donation to the links provided below.  Thank you and enjoy the episode!Links For The Occult Rejectshttps://linktr.ee/theoccultrejectsOccult Research Institutehttps://www.occultresearchinstitute.org/Cash Apphttps://cash.app/$theoccultrejectsVenmo@TheOccultRejectsBuy Me A Coffeebuymeacoffee.com/TheOccultRejectsPatreonhttps://www.patreon.com/TheOccultRejectsPrimary / traditional texts and core religious sourcesĀnāpānasati Sutta (MN 118), translated by Thanissaro Bhikkhu, Access to Insight. Best primary source for Buddhist mindfulness of breathing.“Ḏekr / Dhikr,” Encyclopaedia Iranica. Strong source for Sufi remembrance, rhythmic repetition, posture, and breathing-linked practice.“Hesychasm,” Encyclopaedia Britannica. Good general source for the Christian contemplative tradition of stillness, uninterrupted prayer, and the Jesus Prayer.“Saint Gregory Palamas,” Encyclopaedia Britannica. Useful for the role of bodily posture and controlled breathing in Hesychast prayer.Crowley, Aleister. Liber E vel Exercitiorum. Primary text for Crowley's explicit inclusion of “Pranayama – Regularisation of the Breathing” in occult training.Crowley, Aleister. Book Four, Part 1. Useful for Crowley's statement that pranayama is useful in “quieting the emotions and appetites.”Historical / religious context“Prana,” Encyclopaedia Britannica. Best short source for the deep Indian background: prāṇa, the five prāṇas, and breath as vital force.“Pranayama,” Encyclopaedia Britannica. Best short source for classical Yoga: pranayama as the fourth limb aimed toward samādhi.“Hatha Yoga,” Encyclopaedia Britannica. Useful for the force-oriented turn: bodily mastery, purification, and regulation of breathing.“Qi,” Encyclopaedia Britannica. Good for Daoist and Chinese background: qi as psychophysical energy and breath-linked vital force.“Qigong,” Encyclopaedia Britannica. Useful for qigong as a discipline combining movement, breathing, and mental concentration.“Are Kabbalistic Meditations all about Ecstasy?” in Hermes Explains (Cambridge). Strong academic source for Abraham Abulafia and ecstatic Kabbalah.“Classical Kabbalah, Its History and Symbolic Universe.” Useful academic source noting ecstatic Kabbalah's breathing exercises, postures, and developed techniques.Neuroscience / physiology / altered statesAshhad, Kam, Del Negro, and Feldman. “Breathing Rhythm and Pattern and Their Influence on Emotion.” Annual Review of Neuroscience (2022). One of the best overview papers for the whole episode.Yackle et al. “Breathing control center neurons that promote arousal in mice.” Science (2017). Key source for the preBötzinger complex / calm-vs-arousal section.Schottelkotte and Dutschmann. “Forebrain control of breathing: Anatomy and potential functions.” Frontiers in Neurology (2022). Best source for cortex, amygdala, hippocampus, hypothalamus, and thalamus in breathing control.Krohn et al. “The integrated brain network that controls respiration.” eLife (2023). Strong review for respiration as part of a larger integrated brain network.Heck et al. “Breathing as a fundamental rhythm of brain function.” Human MEG work on respiration-modulated brain oscillations across frequency bands and brain regions.(Note: the specific MEG paper surfaced in earlier research as the respiration-modulated oscillations study; the review sources above are the strongest anchors for that section.)Zelano et al. “Nasal Respiration Entrains Human Limbic Oscillations and Modulates Cognitive Function.” Journal of Neuroscience (2016). One of the most important human papers in the whole script.Schreiner et al. “Respiration modulates sleep oscillations and memory reactivation in humans.” Nature Communications (2023). Best source for the sleep-spindle / memory-reactivation section.Zaccaro et al. “How Breath-Control Can Change Your Life: A Systematic Review on Psychophysiological Correlates of Slow Breathing.” Frontiers in Human Neuroscience / PMC version (2018). Best broad source for slow breathing under 10 breaths per minute.Shao, Man, and Lee. “The Effect of Slow-Paced Breathing on Cardiovascular and Emotion Functions: A Meta-Analysis and Systematic Review.” Mindfulness (2024). Useful for the stabilizing-road section.Kozhevnikov et al. “Neurocognitive and Somatic Components of Temperature Increases during g-Tummo Meditation.” PLoS ONE (2013). Best source for vase breathing and inner-heat claims.Zhang et al. “Hyperventilation in neurological patients: from physiology to outcome evidence.” Useful source for hypocapnia, cerebral vasoconstriction, and reduced cerebral blood flow.Havenith et al. “Decreased CO2 saturation during circular breathwork supports emergence of altered states of consciousness.” Communications Psychology (2025). The key modern paper for circular breathwork and altered-state onset. Also want to remind people about the website, if you're into reading we have tons of information by multiple contributors, and we got t-shirts up on the site if you're interested. Fun fact, the art is all based on the eyeball. Now let me introduce the rest of the panel and guests.

  In this episode, Ray Cochrane leads with Mozilla shipping Firefox 150 with 271 patched bugs found by Anthropic’s Mythos system, the first major real-world deployment of the AlphaGo-Moment cybersecurity tooling. He also covers a 9-year dormant Linux kernel root, a college student stopping Taiwan’s high-speed rail with a software-defined radio, GitHub MCP secret scanning going GA, the NVIDIA NeMo lawsuit surviving its motion to dismiss, the Hugging Face Reachy Mini app store, Anthropic’s Auto Mode for Claude Code, and the 4-gigabyte AI model Chrome silently installed on your computer. – Want to start a podcast? Its easy to get started! Sign-up at Blubrry – Thinking of buying a Starlink? Use my link to support the show. Subscribe to the Newsletter. Email Ray if you want to get in touch! Like and Follow Geek News Central’s Facebook Page. Support my Show Sponsor: Best Godaddy Promo Codes Get 1Password Full Summary Cochrane opens the show with the AlphaGo Moment moving from theory into production. Mozilla shipped Firefox 150 this week with 271 patched bugs that Anthropic’s Mythos system found. Furthermore, the broader episode threads a clear pattern: AI tooling is reshaping security, developer workflows, and consumer software faster than the surrounding ecosystem can absorb it. The show closes on the four-gigabyte AI model Chrome installed on a billion machines without explicit consent. Mozilla Ships 271 Mythos Bugs in Firefox 150 Mozilla ran Anthropic’s restricted Mythos system against the Firefox 150 codebase before shipping. The result: 271 found bugs (180 high severity, 80 moderate, 11 low) baked into the release. However, the bigger number is the year-over-year jump. April 2026 shipped 423 total Firefox security fixes versus 31 a year prior. The breakdown for April: 271 from Mythos, 41 from external researchers, and 111 from other internal sources. Cochrane is sticking to his guns on calling this the AlphaGo Moment for cybersecurity. Skeptics argue Mythos is industrial-scale fuzzing because most found bugs sit in memory-safety territory. However, his counter is the velocity itself. Furthermore, he frames the resistance as carriage-versus-cars: humans-first research still grounds the tool, but throughput is the win. The Firefox CTO put it directly: defenders finally have a chance to win, decisively. For developers asking whether Mythos changes anything if they already run fuzzers, Cochrane’s answer is yes, and not even close. Additionally, he notes Mythos is restricted-access. The broadly available tier is Claude Opus 4.7, which Mozilla used since February before getting onto the restricted program for the Firefox 150 cycle. Run Opus 4.7 first. Sponsor: GoDaddy GoDaddy has been sponsoring this show for over twenty years. Economy hosting starts at $6.99/month, WordPress hosting at $12.99/month, and domains at $11.99. Use codes at geeknewscentral.com/godaddy for exclusive deals and to directly support the show. Copy Fail: 9-Year Linux Kernel Bug, 732 Bytes to Root A 9-year-old dormant Linux kernel bug got disclosed April 29 as CVE-2026-31431. Researchers published a 732-byte Python script that roots every major Linux distribution shipped since 2017. Additionally, CISA added the CVE to its Known Exploited Vulnerabilities catalog on May 1 with a May 15 federal deadline. The bug lives in the kernel’s crypto socket layer through the AF_ALG AEAD interface, originating in a 2017 in-place crypto optimization that lacked bounds checking. Cloudflare published their post-mortem this week. Their first instinct was to remove the kernel module entirely. However, service dependencies forced a workaround instead. Cloudflare resumed normal patched-kernel reboot automation across their 330-city fleet on May 4, with manual reboots and rollouts continuing after. Taiwan Rail Stopped by a 23-Year-Old With a Software-Defined Radio A 23-year-old Taiwanese university student with the surname Lin spoofed a TETRA general alarm signal on April 5, stopping trains on Taiwan’s high-speed rail. The accomplice supplied the radio parameters. Both were arrested by month-end. Lin posted NT$100,000 bail; the accomplice posted NT$80,000. The incident hit at 11:23 PM during the Qingming holiday weekend, stopping three revenue passenger trains plus one deadhead. Furthermore, the system has been in service for 19 years without rotating its cryptographic parameters once. Cochrane notes this is exactly the type of long-dormant infrastructure flaw that Mythos-class tooling catches, if anyone bothers to point it at the wires we already have. GitHub MCP Secret Scanning Goes GA GitHub’s secret scanning in the MCP server hit GA on May 5, with dependency scanning entering public preview the same day. Both released after a seven-week public preview run starting March 17. Additionally, the feature lets MCP-compatible coding agents (Copilot CLI, VS Code, JetBrains, Claude Code, Cursor, Windsurf) detect exposed secrets before commits or pull requests. Findings are ephemeral. They surface only in the current chat session and don’t persist as GitHub alerts. Sources disagree on scope: GitHub’s GA changelog says repo-level or org-level settings work, while the docs say only org-level applies. Cochrane flags the open question of whether MCP prompt injections could be exploited to send discovered secrets elsewhere. Subquadratic Debuts a 12-Million-Token Context Window Miami-based Subquadratic emerged from stealth on May 5 with a $29 million seed round and a reported $500 million valuation. Their model, SubQ 1M-Preview, runs on a new Subquadratic Sparse Attention architecture (their technical writeup calls it Selective Attention; same acronym, different second word). The headline claim: a thousand-times reduction in attention compute at 12 million tokens versus frontier models. However, that figure is vendor marketing math. There is no peer-reviewed paper, no public weights, and no independent benchmark replication. Researchers are demanding independent proof. Furthermore, CTO Alex Whedon’s pull line, “Retrieval / RAG plumbing is a waste of human intelligence,” signals how aggressively they want to position against retrieval-augmented architectures. ChatGPT Goblins, China’s “Catch You Steadily”: Sycophancy Is Universal Last week’s ChatGPT goblin obsession has a Chinese-language twin. The model overuses a phrase translating as “I will steadily catch you.” Additionally, a new Stanford and CMU study called ELEPHANT shows social sycophancy is universal across all 11 LLMs tested with 2,400-plus participants. Models endorsed users 49 percent more than humans did, and 47 percent even on harmful prompts. Alibaba’s Qwen and DeepSeek topped the rankings. Cochrane notes sycophancy is obvious once you’re aware of it but tricky to dissuade. Even with explicit instructions, longer context windows can reintroduce the behavior as the instructions get diluted. Furthermore, the trap is believing you’ve handled it. Once you think you’ve got it under control, you’re more prone to being influenced because you stopped watching for it. NVIDIA NeMo Lawsuit: Judge Tigar Denies Motion to Dismiss Three authors filed Nazemian v. NVIDIA in March 2024, alleging NVIDIA used The Pile and Books3 (approximately 196,640 pirated books) to train its NeMo AI framework. NVIDIA’s defense relied on the Sony v. Universal Betamax doctrine, arguing NeMo’s training scripts are general-purpose tools like a VCR. This week, Judge Tigar denied NVIDIA’s motion to dismiss in the Northern District of California. The headline quote: NeMo’s training scripts “have no other purpose than to speed up the process of infringement.” Furthermore, the judge rejected the VCR analogy outright. NeMo’s scripts are not general-purpose tools; they were allegedly purpose-built to ingest pirated material. Cochrane reads the Betamax framing as legal-jargon arbitrage rather than honest defense. The Humanoid Robot Market Is Smaller Than the Hype Michael Barnard at CleanTechnica argues that scenario-math against the global labor market puts realistic humanoid TAM at $200 billion to $1 trillion, not $20 trillion. Near-term wins cluster in warehouses, not homes. Additionally, the framework weighs dexterity burden against human-proximity safety burden. Real opportunities cluster where both burdens are low. Cochrane connects this to last week’s reservations about humanoids in the household. Furthermore, the risk profile is the issue: these robots aren’t prepared for every scenario, can’t make dynamic decisions, and one software update can change the definition of “safe.” Hugging Face Launches Reachy Mini App Store Hugging Face launched an open-source app store for the Reachy Mini robot this week, $299 for the Lite tethered version and $449 wireless. There are 200-plus community-built apps at launch from over 150 creators, with nearly 10,000 Reachy Minis cumulative shipped. Additionally, apps are forkable, with the default agent (ML Intern) able to modify, write, test, and ship code on any existing app. Examples at launch include an office receptionist built in under two hours, a Reachy Phone Home anti-procrastination app, baby-monitor-style apps, a cooking assistant, and a 78-year-old Joel Cohen’s voice-controlled CEO peer-group app. Pollen Robotics, the company behind Reachy, was acquired by Hugging Face on April 14, 2025. Bebop the Humanoid Robot Delays Southwest Flight 1568 A 4-foot, 70-pound humanoid robot named Bebop delayed Southwest flight 1568 from Oakland to San Diego by more than 73 minutes on April 30. The crew flagged the lithium battery as oversized. Furthermore, the battery was reportedly four times the cabin limit. Bebop belongs to Dallas-based Elite Event Robotics, which bought a full-price cabin ticket because the robot exceeded checked-baggage weight. Bebop danced for passengers at the gate before boarding. However, Southwest had Elite remove the batteries before departure, and replacements were overnighted to Chicago for the next event. Cochrane flags the obvious: batteries have always been flagged in aviation, so forgetting that with a humanoid robot in tow is a strange miss. Ouster Rev8: Native Color Lidar With Google, Volvo, Skydio Stating Intent Ouster announced the Rev8 OS Family on May 4 in San Francisco. The sensors fuse depth and color via SPAD detectors (single photon avalanche diodes) on Ouster’s custom L4 and L4 Max chips. Google, Volvo Autonomous Solutions, Skydio, Liebherr, Epiroc, and PlusAI have stated intent to adopt, though nothing is formally signed. Specs include 48-bit color, 116 dB dynamic range, and pre-fused 3D colorized point clouds. The OS1 Max gets 500-meter max detection. Available to order today and shipping this quarter, with no pricing disclosed. CEO Angus Pacala in his TechCrunch interview: “The goal is to obviate cameras. There’s no reason that one sensor can’t do both.” TagTinker Lets a Flipper Zero Mess With Electronic Shelf Labels A new Flipper Zero app called TagTinker uses infrared signals to push images and text to electronic shelf labels. Additionally, these are the same kind of price tags grocery chains are starting to use for surveillance pricing. The app and GitHub repo went public this week. Maryland’s HB 895, signed by Governor Wes Moore, takes effect October 1 as the first-in-nation surveillance pricing law. It covers food retailers and third-party food delivery service providers. Furthermore, ESLs use the same IR signaling as TV remotes with weak security. The dev’s disclaimer states it’s strictly for educational research, security curiosity, and displaying digital art on hardware you legally own. Fitbit App Becomes Google Health, Plus Fitbit Air, Plus Google Fit Sunset Google announced May 7 that the Fitbit app becomes Google Health on May 19, rolling through May 26. The launch ships with the new $99.99 Fitbit Air screenless tracker and the long-rumored Google Fit shutdown. Additionally, the four-tab interface (Today, Fitness, Sleep, Health) bundles a Gemini-powered AI Health Coach. Coach is premium-gated at $9.99/month or $99/year. Medical records integration is US-only at launch. The Fitbit Air gets up to one week of battery life and 50-meter water resistance. However, Cochrane flags conflicting privacy framing: Google’s AI summary bullets say “your data stays private,” but the actual document copy says only “committed to not using Fitbit user health and wellness data for Google Ads.” Those are not the same statement. Russinovich on Why Win32 Won and WinRT Didn’t Microsoft Azure CTO Mark Russinovich said via Microsoft Dev Docs video that Win32, the 1995 API, is still foundational to Windows 11. WinRT, the modernization replacement, “didn’t play out the way a lot of people expected.” Mostly clickbait framing per Windows Latest, but the substantive angle is real. Microsoft is pivoting back to native WinUI 3 development after years of pushing developers toward WebView2 and Electron. Additionally, Electron-based apps are known for insane RAM usage, and everyone is hurting for RAM right now. Furthermore, the bigger open question is whether Electron survives the test of time, especially with the React engine reportedly being rewritten in Rust. “Tabula Plena”: The Brain Starts Full, Not Blank A Nature Communications study from the Institute of Science and Technology Austria found that the mouse hippocampal CA3 recurrent network begins densely connected and refines through pruning. ISTA’s press release frames this as “tabula plena,” meaning full slate, counter to tabula rasa. The paper published April 21. First author Victor Vargas-Barroso and senior author Professor Peter Jonas studied mice at three developmental stages. Furthermore, the “starting overloaded enables faster sensory integration” framing is Jonas’s hypothesis from the press release, not a paper conclusion. Cochrane closes on the bigger question: did we have human growth and experience mapped wrong from the start? The Aqueous Battery You Can Pour Down the Drain A Chinese research team led by Professor Chunyi Zhi at City University of Hong Kong built an aqueous battery using a custom organic polymer electrode plus neutral magnesium and calcium salts (food-grade tofu coagulants) as electrolyte. Published in Nature Communications on February 18. Numbers to know: 120,000-plus charge cycles, full-cell energy density of 48.3 watt-hours per kilogram. That’s well below typical lithium-ion. However, post-cycling analysis showed only magnesium, calcium, chlorine, carbon, and copper, with no heavy metals. The cell complies with US RCRA, ISO 14001, and China’s GB 18599-2020 for direct environmental disposal. Additionally, the “300-plus years” framing is journalists extrapolating from the 120,000 cycles, not a paper claim. ResoNix Klippel Tests Expose Car-Audio Spec Lies Nick Apicella, founder of ResoNix Sound Solutions in Stony Point, New York, spent around $23,000 on independent Klippel LSI and TRF testing of 40 subwoofers. He published 21 results showing widespread misrepresentation of Xmax (excursion) and thermal/power-handling claims. Test data published in three batches between December 2025 and January 2026. Specifics: Wavtech thinPRO12 claimed 20 mm of excursion but delivered 8.85 mm, scoring 15 out of 100 on marketing accuracy. One driver hit 44 percent of advertised excursion. Another tripped thermal protection at half its rated power. Additionally, nine of 21 drivers scored below 50 out of 100. Brands tested include JL Audio, Sundown, Focal, Morel, Audiofrog, Adire, Stereo Integrity, and Dynaudio. Conflict-of-interest flag: ResoNix’s own GUS-15, 12, and 10 prototypes conveniently rank one, two, three. JetBrains Opens 2026 Developer Ecosystem Survey JetBrains opened the 10th annual Developer Ecosystem Survey this week. It takes about 30 minutes, with prizes including a MacBook Pro 16-inch and a $1,000 Amazon gift card. Anonymized raw data is published publicly, and cumulative scale is 100,000-plus developers across recent years. Additionally, the survey is going fully anti-AI: “evil bots, dishonest respondents, and AI agents will be excluded from prize distribution.” Cochrane is curious whether TypeScript holds its 2025 crown after knocking Python off, and whether Rust shows real growth given the wave of LLM-driven Rust rewrites in the past few months. Anthropic’s Claude Code Auto Mode Goes Live Anthropic launched Auto Mode for Claude Code roughly six weeks ago. Claude Code’s previous behavior required user approval for most file modifications and command executions, generating heavy approval-fatigue complaints during longer sessions. Auto Mode is the answer: Claude can run multi-step development tasks without per-action approval. Additionally, the architecture is a two-stage classifier, with stage one a fast yes/no filter and stage two doing chain-of-thought on flagged actions. Cochrane runs his own Claude Code in YOLO mode but with custom rejection rules baked into settings to block commands he doesn’t want, even with skip-permissions on. He recommends configuring settings as the actual policy layer rather than relying on classifier judgment alone. Furthermore, recent posts about Claude deleting websites or wiping production databases reinforce why the settings layer matters more than the auto-mode toggle. Chrome Quietly Installed a 4GB AI Model on Your Computer Google Chrome silently downloads on-device AI model weights (Gemini Nano family) to a `weights.bin` file in the OptGuideOnDeviceModel directory, around four gigabytes in Alexander Hanff’s audit. Furthermore, the model re-downloads if you delete it. Hanff timed his own install at 14 minutes 28 seconds on macOS. Affected platforms include Windows, macOS (including Apple Silicon), and Linux. Hanff frames this as a multi-front legal violation: a direct breach of Europe’s ePrivacy Directive, two articles of GDPR, and an environmental harm of a magnitude that would be notifiable under the Corporate Sustainability Reporting Directive. At one billion users, the four-gigabyte distribution represents roughly 240 gigawatt-hours of network and storage energy paired with about 60,000 tonnes of CO2-equivalent emissions. However, no EU regulator action or formal complaint has surfaced as of this episode. The model powers on-device features (email writing, scam detection, summarization, smart paste, tab grouping) but not the visible AI Mode button, which routes to the cloud. To disable, Cochrane recommends Chrome Settings, then System, then On-device AI, toggle to off. Two more paths exist via `chrome://flags` or a Windows registry edit. Cochrane closes the show with show housekeeping: GNC Insider at geeknewscentral.com/insider, email at geeknews@gmail.com, newsletter signup at geeknewscentral.com, and Pocket Casts as a solid modern podcast app pick. Have a wonderful night. The post Mozilla Meets Mythos #1864 appeared first on Geek News Central.

Registered dietitian nutritionist Leyla Muedin discusses a Nature Communications study of 108,723 French adults in the NutriNet-Santé cohort (2009–2023) examining long-term exposure to food preservatives and type 2 diabetes. Using detailed dietary records cross-referenced with product/additive databases, researchers identified 58 preservative-related additives and analyzed 17 consumed by at least 10% of participants; 1,131 diabetes cases occurred. Higher overall preservative intake was associated with a 47% increased diabetes risk (49% for non-antioxidant preservatives; 40% for antioxidant additives), with several specific additives linked to higher risk. Leyla questions whether the findings reflect preservatives themselves or the ultra-processed, refined-carbohydrate foods that contain them, emphasizing recommendations to favor fresh, minimally processed foods and limit refined carbs and processed foods.

La banana que comes cada mañana podría desaparecer. No es exageración ni titular de tabloides: el hongo Fusarium TR4 avanza sin freno por las plantaciones de banana Cavendish en más de 23 países, y ningún fungicida del mundo puede detenerlo. En este episodio explicamos por qué la fruta más exportada del planeta está viviendo una crisis silenciosa con consecuencias globales.La Cavendish representa el 95% de las exportaciones mundiales de banana y mueve más de 14,000 millones de dólares al año. Ecuador, Colombia, Perú y Filipinas sostienen esa cadena. Pero todas esas plantas son clones genéticamente idénticos, lo que las convierte en blancos perfectos para un patógeno que ya aprendió a matarlas.Esto ya pasó antes. La Gros Michel, la banana que dominó el comercio mundial hasta los años sesenta, fue eliminada por el mismo tipo de hongo. La industria cambió de variedad y siguió adelante sin resolver el problema de fondo. Hoy estamos en el mismo punto, con menos tiempo y más en juego.En este episodio vas a entender cómo funciona el TR4, por qué contamina el suelo para siempre, cómo llegó a América Latina y qué está haciendo la ciencia para encontrar una salida, incluyendo el primer banano transgénico aprobado para producción comercial en Australia en 2024.Una historia de monocultivo, geopolítica agrícola y un hongo que no distingue fronteras. Si alguna vez quisiste entender por qué la agricultura industrial es tan frágil, este episodio es el ejemplo más concreto que vas a escuchar.Escucha Agricultura Profesional:https://open.spotify.com/show/2ZuOW2DhD7PK4SM33gtFWy?si=e33021063a114550--Créditos musicales:INTROMusic from #Uppbeat (free for Creators!):https://uppbeat.io/t/kevin-graham/53License code: 62TIV9S8Q1XCM65WOUTROMusic from #Uppbeat (free for Creators!):https://uppbeat.io/t/ra/let-good-times-rollLicense code: KUSUTAITXDLYUTHQ--Fuentes consultadas:FAO, Organización de las Naciones Unidas para la Alimentación y la Agricultura. «Banano: Análisis del Mercado 2023». Disponible en: https://www.fao.org/markets-and-trade/commodities-overview/bananas-tropical-fruits/bananas/esMunhoz, T., Vargas, J., Teixeira, L., Staver, C., Dita, M. (2024). «Fusarium Tropical Race 4 in Latin America and the Caribbean: status and global research advances towards disease management». Frontiers in Plant Science, 15:1397617. DOI: 10.3389/fpls.2024.1397617. Disponible en: https://pubmed.ncbi.nlm.nih.gov/39081528/Harding, R., Paul, J.-Y., James, A., et al. (2025). «QCAV-4, the first genetically modified Cavendish banana resistant to Fusarium wilt tropical race 4 approved for commercial production and consumption». Plant Biotechnology Journal, 23: 3628-3637. DOI: 10.1111/pbi.70178. Disponible en: https://onlinelibrary.wiley.com/doi/full/10.1111/pbi.70178Dale, J., James, A., Paul, J.-Y., et al. (2017). «Transgenic Cavendish bananas with resistance to Fusarium wilt tropical race 4». Nature Communications, 8, artículo 1496. DOI: 10.1038/s41467-017-01670-6. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684404/Ploetz, R. C. (2018). «Fusarium Wilt of Banana: Current Knowledge on Epidemiology and Research Needs Toward Sustainable Disease Management». Frontiers in Plant Science. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202804/

The two program chairs of the annual meeting of the International Society for Stem Cell Research talk about the meeting and some trends they see. They are Dr Fiona Doetsch from the University of Basel and Dr Nozomu Yachie from the University of British Columbia who has a lab at the University of Osaka too. They talk about the promise of stem cell biology and stem cell therapy. About how malleable the human brain is, the role of AI and 'in vivo veritas. There's also a word association game. My co-moderator is: Dr. Angela Parrish from Nature Communications who has also worked at Nature Cell Biology. 

Wann hast Du das letzte Mal körperlich auf etwas reagiert? Nicht auf eine Nachricht – sondern auf etwas, das fiel, flog oder plötzlich da war?Falls Dir spontan nichts einfällt: Diese Folge ist für Dich.Du erfährst, warum klassisches Dehnen meistens scheitert – und was stattdessen funktioniert („Unlock statt Stretch“). Du lernst die zwei Bewegungsmuster kennen, die über Deine Koordination entscheiden. Und Du bekommst vier Werkzeuge, die Du ab morgen nutzen kannst – darunter ein 5-Minuten-Morgenritual und ein Besenstiel-Spiel, das Deine Ausdauer mindestens so gut fordert wie eine Runde Joggen.In dieser Folge: Warum Dein Nervensystem „einrostet“, wenn Du es nicht überraschstDie 85-Prozent-Regel: der Sweetspot für motorisches LernenVier sofort umsetzbare Übungen (kein Equipment, kein Studio)Warum Geräusche beim Training ein Warnsignal sind____________*WERBUNG: Infos zum Werbepartner dieser Folge und allen weiteren Werbepartnern findest Du hier.____________► Video zum Morgen-Unlock: Die meistgefragte Übung aus dieser Folge als kurzes Anleitungsvideo – hier im Blogartikel.► Erwähnte Studie: Wilson, R. C., Shenhav, A., Straccia, M., & Cohen, J. D. (2019). The Eighty Five Percent Rule for optimal learning. Nature Communications, 10, 4646.____________Shownotes und Übersicht aller Folgen.Trag Dich in Marks Dranbleiber Newsletter ein.Entdecke Marks Bücher.Folge Mark auf Instagram, Facebook, Strava, LinkedIn. Hosted on Acast. See acast.com/privacy for more information.

Sponsor LinkTo check out our special NordVPN offer for Astronomy Daily listeners: Click HereAstronomy Daily — S05E90 | Wednesday, April 22, 2026 In today's episode, Anna and Avery cover six stories spanning the fading power of humanity's most distant probe, fresh evidence for ancient life on Mars, a landmark black hole measurement, a SpaceX reusability milestone, a sobering assessment of the Artemis spacesuit programme, and tonight's moon and Jupiter conjunction.   Story 1 — Voyager 1 Powers Down the LECP Instrument •       NASA's JPL shut down Voyager 1's Low-energy Charged Particles experiment (LECP) on April 17, 2026, to conserve dwindling power. •       The decision followed an unexpected power drop during a routine roll manoeuvre in late February that nearly triggered an automatic emergency shutdown. •       Seven of Voyager 1's ten original instrument sets are now offline. Only the magnetometer and plasma wave subsystem remain active. •       Engineers are developing 'the Big Bang' — a plan to swap older components with lower-power alternatives — to extend operations into the 2030s. Testing on Voyager 2 is planned for May/June 2026; Voyager 1 to follow no sooner than July. •       Source: NASA JPL — https://www.jpl.nasa.gov/news/nasa-shuts-off-instrument-on-voyager-1-to-keep-spacecraft-operating/   Story 2 — Curiosity Rover Finds Organic Molecules on Mars •       Published April 21 in Nature Communications, the study describes the first use of the TMAH chemical experiment on another planet. •       More than 20 organic molecules were detected in clay-rich sandstone from the Glen Torridon region of Gale Crater, preserved for over 3.5 billion years. •       Discoveries include a nitrogen-bearing molecule structurally similar to DNA precursors — never before confirmed on Mars — and benzothiophene. •       The experiment cannot determine whether molecules are biological, geological, or meteoritic in origin. Future missions including Rosalind Franklin and Dragonfly will build on the technique. •       Source: phys.org — https://phys.org/news/2026-04-mars-rover-compounds.html   Story 3 — Black Hole Jets in Cygnus X-1 •       Curtin University-led study published April 16 in Nature Astronomy directly measures the instantaneous power of black hole jets for the first time. •       The jets in the Cygnus X-1 system carry energy equivalent to 10,000 suns and travel at approximately half the speed of light (150,000 km/s). •       Researchers used the companion star's stellar winds to 'bend' the jets, allowing calculation of their real-time power — a technique compared to watching wind deflect a fountain. •       About 10% of the energy released as matter falls into the black hole is carried away by the jets — confirming a long-held theoretical assumption. •       The measurement will help calibrate future observations from the Square Kilometre Array Observatory, currently under construction in WA. •       Source: ScienceDaily — https://www.sciencedaily.com/releases/2026/04/260416071949.htm   Story 4 — SpaceX 600th Rocket Landing •       SpaceX completed its 600th successful Falcon booster landing on April 19, 2026, during the Starlink 17-22 mission from Vandenberg SFB. •       Booster B1097 landed on drone ship 'Of Course I Still Love You' for its eighth successful recovery. The milestone arrived just 7 months after the 500th landing. •       The tally includes 496 drone ship landings and 104 ground landings, per SpaceX VP Kiko Dontchev. •       SpaceX's Starlink constellation now numbers over 10,275 satellites in orbit. •       Source: Space.com — https://www.space.com/space-exploration/launches-spacecraft/spacex-starlink-17-22-b1097-vsfb-ofisly-600th-falcon-landing   Story 5 — Artemis Spacesuit Crisis •       NASA's Office of Inspector General report (released April 20) warns that next-generation Artemis spacesuits may not be ready until 2031 — three years after the stated 2028 target. •       The xEVAS programme began as a two-company competition (Axiom Space + Collins Aerospace). Collins has effectively been removed after missing milestones. Axiom is now the sole contractor for the lunar surface suit. •       OIG analysis: based on an 8.7-year historical average from contract award to first flight for comparable NASA programmes, Axiom's 2022 award points to a 2031 delivery. •       NASA Administrator Isaacman has publicly maintained confidence in the 2028 date. Axiom plans a suit demonstration in 2026 on the ISS or during an Artemis mission. •       A separate risk: if the ISS variant of the suit slips past 2030, the Station could run out of operational EVA suits before decommissioning. •       Additional Artemis delays: SpaceX lunar Starship at least 2 years late; Blue Origin Blue Moon at least 8 months late (per separate March OIG report). •       Source: SpaceDaily — https://spacedaily.com/sd-n-the-spacesuit-gap-why-artemis-iiis-2028-landing-date-is-already-slipping/   Story 6 — Skywatching: Moon & Jupiter Conjunction •       Tonight (April 22), the half moon sits approximately 3 degrees from Jupiter in the constellation Gemini, near the stars Castor and Pollux. •       Visible to the naked eye in the western/northwestern sky after sunset. Binoculars will reveal Jupiter's four Galilean moons. •       Southern Hemisphere viewers: look northwest after dark; viewing window narrows the further south you are. •       Source: Space.com — https://www.space.com/stargazing/the-moon-and-jupiter-steal-the-show-after-sunset-on-april-22Become a supporter of this podcast: https://www.spreaker.com/podcast/astronomy-daily-space-news-updates--5648921/support.Sponsor Details:Ensure your online privacy by using NordVPN. To get our special listener deal and save a lot of money, visit www.bitesz.com/nordvpn. You'll be glad you did!Become a supporter of Astronomy Daily by joining our Supporters Club. Commercial free episodes daily are only a click way... Click HereThis episode includes AI-generated content.

What can the DNA of Neanderthals, woolly mammoths, and ancient proteins tell us about the future of medicine? In this episode, Professor César de la Fuente sits down to discuss his fascinating research goal: using the power of machines to accelerate discoveries in biology and medicine… This conversation explores: The growing global health threat of antimicrobial resistance (AMR). Why ancient DNA and extinct organisms may hold clues for next-generation antibiotics. The role that AI plays in uncovering the genetic data of extinct organisms. What the future of machine biology could mean for human health. Prof. de la Fuente is Presidential Associate Professor at the University of Pennsylvania, where he leads the Machine Biology Group. He is one of the youngest tenured professors in the history of Penn Medicine. He completed postdoctoral research at MIT and earned his PhD from the University of British Columbia. He is widely recognized for pioneering the first computer-designed antibiotic shown to be effective in animal models, which is an achievement that helped launch the emerging field of AI-driven antibiotic discovery. His lab has since identified more than one million potential antimicrobial compounds through computational biology. In addition, Prof. de la Fuente has delivered over 350 invited lectures worldwide, co-authored an influential book on machine learning for drug discovery, secured multiple patents, and published more than 180 peer-reviewed papers in leading journals, including Cell, Science, Nature Communications, PNAS, and Advanced Materials. You can follow Prof. de la Fuente's latest discoveries and research here!

Hoy vivimos en un planeta relativamente frío, con grandes masas de hielo permanentes en los polos. Sin embargo, durante la era de los dinosaurios y hasta hace unos 34 millones de años, la Tierra era muy diferente: predominaba un mundo “invernadero”, con temperaturas globales más cálidas y sin glaciares permanentes. Un nuevo estudio internacional, publicado en Nature Communications y en el que participa la investigadora de la Universidad de Zaragoza y del Instituto Universitario de Investigación en Ciencias Ambientales de Aragón (IUCA) Laia Alegret, catedrática de Paleontología, analiza cómo reaccionó la vida marina ante uno de los grandes cambios climáticos de la historia de la Tierra: el paso de ese planeta cálido a otro más frío., hace 34 millones de años. Tal y como explica Alegret en Ágora, este estudio analiza más de 40.000 registros de microfósiles procedentes de 161 localidades de todo el mundo. Su complejidad ha impulsado el desarrollo de un nuevo método analítico basado en inteligencia artificial, por parte de la Universidad de Nanjing. Los resultados indican que las aguas profundas – y la vida que habitaba en ellas- se vieron menos afectadas por los cambios climáticos que las aguas someras durante este periodo.

Jay Gunkelman, Joy Lunt, John Mekrut, Anthony Ramos, and Santiago Brand go live for a Brain Bar panel that pulls no punches — and Anthony drops a Nature Communications study mid-show that stops everyone cold. Boys born to mothers with high BPA levels are 3.5x more likely to show autism symptoms by age two and 6x more likely to be diagnosed by age eleven.The panel also takes on the DSM, photobiomodulation, and the single most important distinction in the field — we train brains, we don't treat them.

Has quantum advantage actually been achieved — or is the field still arguing over its own milestones? Dominik Hangleiter, one of the leading theorists working on quantum computational advantage, joins the podcast to make the case that it has, explain why so many physicists remain unconvinced, and map the path toward fault-tolerant, verifiable quantum advantage.Why This Episode MattersIf you follow quantum computing and want to cut through the noise around quantum advantage claims, this episode is for you. Dominik Hangleiter — an Ambizione Fellow at ETH Zürich and postdoctoral fellow at UC Berkeley's Simons Institute — has spent over a decade studying the boundary between what quantum and classical computers can do. His March 2026 paper "Has quantum advantage been achieved?" synthesizes years of experiments, classical simulation attacks, and complexity theory into a clear-eyed assessment. Whether you're an experimentalist, a theorist, or simply quantum-curious, you'll come away with a sharper understanding of what's been demonstrated, what hasn't, and what comes next.What You'll LearnWhy random circuit sampling became the primary arena for proving quantum advantage — and why the task's "uselessness" is a feature, not a bugHow the linear cross-entropy benchmark (XEB) works as a statistical proxy for verifying classically intractable quantum computationWhy audiences of physicists are still split on whether quantum advantage has been demonstrated, despite multiple experiments since 2019What "peaked circuits" are and how they interpolate between random sampling and structured computationHow post-quantum cryptography (learning with errors) exploits problems that quantum computers can't solve — and what that reveals about quantum computation's limitsWhy basic arithmetic is surprisingly hard for fault-tolerant quantum computers, and how that bottlenecks algorithms like Shor'sHow fault-tolerant compilation co-designs quantum circuits with error-correcting codes to make advantage experiments scalableThe difference between "native" quantum operations and the overhead required for universal fault-tolerant computationWhy the interplay between quantum and classical computing strengths — not quantum dominance — may define the field's futureResources & LinksPapers & ArticlesHas quantum advantage been achieved? — Hangleiter's March 2026 paper synthesizing the quantum advantage debateComputational Advantage of Quantum Random Sampling — Hangleiter & Eisert's comprehensive review in Reviews of Modern Physics (2023)Fault-Tolerant Compiling of Classically Hard IQP Circuits on Hypercubes — The Harvard/ETH collaboration on fault-tolerant IQP circuits (PRX Quantum 2025)Secret-Extraction Attacks against Obfuscated IQP Circuits — Hangleiter & Gross's attack paper breaking proposed verification protocols (PRX Quantum 2025)Verifiable Measurement-Based Quantum Random Sampling with Trapped Ions — Experimental realization with the Innsbruck trapped-ion group (Nature Communications 2025)Blog Series & CommentaryHas quantum advantage been achieved? (Quantum Frontiers blog series) — The three-part mini-series on the Caltech IQIM blog that grew into the paperScott Aaronson's reaction — Endorsement on Shtetl-Optimized: "quantum supremacy on contrived benchmark problems has almost certainly been achieved by now"Guest LinksDominik Hangleiter — personal website & publicationsGoogle Scholar profile (4,372 citations)QuICS profile (University of Maryland)Key Quotes & Insights"Really what sets random circuit sampling apart is that it's really programmable. I give an input to the device, I design a circuit — I draw it randomly, yes — but then I give the circuit to the device, and whoever controls the device runs the circuit and gives me back the samples." — On why RCS qualifies as genuine computation"We typically do in physics experiments a lot of extrapolation, a lot of circumstantial experiments that validate that the experiment you really care about is actually what you want to probe. And that's the sense in which I think these random circuit sampling experiments have been verified." — On the physics-style epistemology of quantum advantage"Classical computers are really good at doing basic arithmetic, but quantum computers — it's really hard to do basic arithmetic. And that's for the reason that fault tolerance is very restrictive in terms of the operations that you can do on encoded information." — On the surprising asymmetry between quantum and classical capabilities"I can't just tell the quantum computer to give me the outcome I want. There's rules to it. And how those rules apply to computational problems that we face in the real world beyond quantum simulation is, I think, a really intriguing challenge." — On the structured nature of quantum interference"Maybe there's a world where we can stitch together different hardware systems and won't have a single platform that wins the race." — On heterogeneous quantum architecturesRelated EpisodesEp 35: Quantum Benchmarking with Jens Eisert — Hangleiter's PhD advisor discusses benchmarking quantum devices — essential context for understanding how we measure quantum performance.Ep 12: Quantum Supremacy to Generative AI and Back with Scott Aaronson — Aaronson's perspective on quantum supremacy and computational complexity — directly relevant to the advantage debate.Ep 73: Peaked quantum circuits with Hrant Gharibyan — The peaked circuits approach discussed in this episode, explained in depth.Ep 47: Megaquop with John Preskill and Rob Schoelkopf — The road to a million quantum operations — the scale needed for the fault-tolerant advantage Hangleiter envisions.Ep 74: Majorana qubits with Chetan Nayak — Another approach to fault tolerance with different native capabilities — relevant to Hangleiter's point about modality-specific strengths.Calls to ActionDominik's Quantum Frontiers blog series is one of the most accessible deep dives on quantum advantage available anywhere — start there if you want to explore beyond this conversation. Links in the show notes.Subscribe: ...

Don't call it a comeback, coelacanth's been here for years. We discuss life on Earth 400 million years ago, a military escort mission, our own fish ancestors, five year pregnancies, underwater handstands, an unnecessarily complicated puzzle in the third generation Pokémon games, and so much more. Works Cited: “The Coelacanth” - Knysna Museum “The Discovery” - UC Museum of Paleontology's website “Earliest known coelacanth skull extends the range of anatomically modern coelacanths to the Early Devonian” - Min Zhu et al., Nature Communications, April 2012 “Animated Life: The Living Fossil Fish | HHMI BioInteractive Video”  “The coelacanth rostral organ is a unique low-resolution electro-detector that facilitates the feeding strike” - Rachel M. Berquist et al., Scientific Reports, March 2015 “New scale analyses reveal centenarian African coelacanths” - Kélig Mahé et al., Current Biology, August 2021 “Neurocranial development of the coelacanth and the evolution of the sarcopterygian head” - Hugo Dutel et al., Nature, May 2019 “Buoyancy and hydrostatic balance in a West Indian Ocean coelacanth Latimeria chalumnae” - Henrik Lauridsen et al., BMC Biology, August 2022 Links: Come hear Ellen talk about dragons LIVE at Nerd Nite Seattle! https://seattle.nerdnite.com/ For more information about us & our podcast, head over to our website! Follow Just the Zoo of Us on BlueSky, Facebook, Instagram & Discord! Follow Ellen on Instagram or BlueSky!

Don't call it a comeback, coelacanth's been here for years. We discuss life on Earth 400 million years ago, a military escort mission, our own fish ancestors, five year pregnancies, underwater handstands, an unnecessarily complicated puzzle in the third generation Pokémon games, and so much more. Works Cited: “The Coelacanth” - Knysna Museum “The Discovery” - UC Museum of Paleontology's website “Earliest known coelacanth skull extends the range of anatomically modern coelacanths to the Early Devonian” - Min Zhu et al., Nature Communications, April 2012 “Animated Life: The Living Fossil Fish | HHMI BioInteractive Video”  “The coelacanth rostral organ is a unique low-resolution electro-detector that facilitates the feeding strike” - Rachel M. Berquist et al., Scientific Reports, March 2015 “New scale analyses reveal centenarian African coelacanths” - Kélig Mahé et al., Current Biology, August 2021 “Neurocranial development of the coelacanth and the evolution of the sarcopterygian head” - Hugo Dutel et al., Nature, May 2019 “Buoyancy and hydrostatic balance in a West Indian Ocean coelacanth Latimeria chalumnae” - Henrik Lauridsen et al., BMC Biology, August 2022 Links: Come hear Ellen talk about dragons LIVE at Nerd Nite Seattle! https://seattle.nerdnite.com/ For more information about us & our podcast, head over to our website! Follow Just the Zoo of Us on BlueSky, Facebook, Instagram & Discord! Follow Ellen on Instagram or BlueSky!

London gets a tiny-but-mighty commute update as TfL redesigns the Baby on Board badge — because sometimes a bit of visual signalling does more than a thousand glares. Alan Leer also breaks down the government's latest numbers on getting a million people online, plus what the UK's 2G switch-off guidance means for older phones and those sneaky “smart” devices you forgot even exist. After the break, it's a proper science gut-punch: Nature reports the UK's main airborne climate and pollution research aircraft is being switched off. Then we end on a brighter note with a Nature Communications sodium-ion battery chemistry result built for extreme cold — and a quick check-in on the UK games industry as TIGA calls for support. More on all of it at standard.co.uk — and follow Tech and Science Daily from The Standard for your weekday briefing. Hosted on Acast. See acast.com/privacy for more information.

It's the first day of astronomical spring — and the universe is celebrating in style. On today's Astronomy Daily, Anna and Avery cover a triple CME solar storm with aurora potential reaching as far south as Illinois, explain why the vernal equinox amplifies aurora activity, report on the ongoing meteorite hunt following Tuesday's spectacular Ohio fireball, reveal an extraordinary 14-billion-year-old star that carries the chemical fingerprints of the universe's very first stars, bring a happy update on Europe's Proba-3 solar science satellite which has ended a month of silence, and explain how X-ray CT scans of returned asteroid samples finally cracked one of Bennu's longest-standing mysteries.   Stories in This Episode 1. Triple CME Strike + Equinox Aurora Alert Three coronal mass ejections (CMEs) are currently en route to Earth, with the first arriving today. Forecasters predict G2 (moderate) to G3 (strong) geomagnetic storm conditions, potentially bringing auroras as far south as Illinois. The timing coincides with the vernal equinox — historically one of the best aurora windows of the year due to the Russell-McPherron effect. 2. The Vernal Equinox — Today! The 2026 March equinox arrived today at 14:46 UTC, marking the astronomical start of spring in the Northern Hemisphere (and autumn in the Southern). Tonight, a thin crescent Moon appears alongside Venus in the west-southwest sky. 3. Ohio Fireball — Meteorite Hunt Underway On St. Patrick's Day (March 17), a seven-ton asteroid exploded over northeast Ohio with the force of 250 tons of TNT. NASA confirmed meteorites landed near Medina County, and hunters from across the US have already found fragments in the Sharon Center area. 4. Ancient 'Cosmic Fossil' Star PicII-503 Astronomers have discovered PicII-503, a second-generation star in the Pictor II dwarf galaxy with only 1/40,000th of the Sun's iron — the lowest ever measured outside the Milky Way. Its extraordinary carbon-to-iron ratio links it to mysterious carbon-enhanced metal-poor stars scattered across our galaxy's halo, solving a long-standing stellar mystery. Published in Nature Astronomy by Anirudh Chiti (Stanford) et al. 5. Proba-3 Phones Home — 'A Great Relief!' ESA confirmed on March 19 that its Proba-3 Coronagraph satellite — silent since mid-February after an anomaly caused it to lose attitude control — has reestablished contact via the Villafranca ground station. The spacecraft is in safe mode, solar-powered, and undergoing health checks before science operations can resume. 6. NASA Cracks Bennu's Boulder Mystery X-ray CT scans of returned OSIRIS-REx samples reveal Bennu's boulders are riddled with internal crack networks — the missing piece explaining the asteroid's puzzling low thermal inertia. Published in Nature Communications. The findings will improve asteroid characterisation from Earth-based telescopes globally.   Source Links Triple CME / Aurora Alert — Space.com: https://www.space.com/stargazing/auroras/aurora-alert-powerful-geomagnetic-storm-could-spark-northern-lights-as-far-south-as-illinois-on-march-19 Triple CME / Sun News — EarthSky: https://earthsky.org/sun/sun-news-activity-solar-flare-cme-aurora-updates/ NOAA Space Weather Prediction Centre: https://www.spaceweather.gov Vernal Equinox 2026 — EarthSky: https://earthsky.org/astronomy-essentials/everything-you-need-to-know-vernal-or-spring-equinox/ Ohio Fireball — EarthSky: https://earthsky.org/earth/sonic-boom-from-a-meteor-cleveland-ohio-and-pennsylvania-mar-17-2026/ Ohio Meteorite Hunt — Cleveland19: https://www.cleveland19.com/2026/03/19/meteorite-hunters-states-away-find-fragments-northeast-ohio/ PicII-503 Discovery — NOIRLab: https://noirlab.edu/public/news/noirlab2607/ PicII-503 — Nature Astronomy (DOI): https://doi.org/10.1038/s41550-026-02802-z Proba-3 Phones Home — Space.com: https://www.space.com/space-exploration/missions/a-great-relief-europes-proba-3-solar-eclipse-satellite-phones-home-after-a-month-of-silence Proba-3 ESA Statement: https://www.esa.int/Enabling_Support/Space_Engineering_Technology/Proba-3_s_Coronagraph_is_alive Bennu Mystery Solved — NASA Science: https://science.nasa.gov/missions/osiris-rex/asteroid-bennus-rugged-surface-baffled-nasa-we-finally-know-why/ Bennu — Nature Communications (SciTechDaily): https://scitechdaily.com/we-were-scratching-our-heads-scientists-finally-solve-asteroid-bennus-surface-mystery/   Find us: astronomydaily.io  |  @AstroDailyPod on Twitter/X, Instagram, TikTok, YouTube & Tumblr Part of the Bitesz.com Podcast NetworkBecome a supporter of this podcast: https://www.spreaker.com/podcast/astronomy-daily-space-news-updates--5648921/support.Sponsor Details:Ensure your online privacy by using NordVPN. To get our special listener deal and save a lot of money, visit www.bitesz.com/nordvpn. You'll be glad you did!Become a supporter of Astronomy Daily by joining our Supporters Club. Commercial free episodes daily are only a click way... Click HereThis episode includes AI-generated content.

Join Dr. Siobhan McCormack and the "fibre-fabulous" Dr. Emily Leeming, a former superyacht chef turned King's College London microbiome scientist and registered dietitian. Discover why fibre is the overlooked "Cinderella nutrient," how it fuels your gut microbiome, and practical, delicious ways to hit your 30-gram daily target without the bloat.What We Cover:The Chef-to-Scientist Pipeline: Dr. Leeming's journey from the high seas to gut health research.The "Blue Poo" Study: What transit time actually is and what it reveals about your digestion.Disease Prevention: How feeding your gut microbiome protects against colorectal cancer and heart disease.Simple Food Combos: Chef-approved tips to easily sneak more whole grains, nuts, and beans into your busy day.About Dr. Leeming is a scientist at King's College London, a dietitian, and part of the Harvard-led PROSPECT team investigating early colorectal cancer. She is the bestselling author and writes the popular Second Brain newsletter for over 30,000 subscribers.Resources Mentioned:Genius Gut: The Life-Changing Science of Eating for Your Second Brain by Dr. Emily LeemingFiber Power by Dr. Emily Leeming (Releasing May 21st)Gut by Giulia EndersThe Psychobiotic Revolution by Scott C. Anderson, John F. Cryan, and Ted DinanScientific References Discussed:O'Keefe SJD, et al. (2015). Fat, fibre and cancer risk in African Americans and rural Africans. Nature Communications.Asnicar F, Leeming ER, et al. (2021). "Blue Poo: Impact of Gut Transit Time on the Gut Microbiome Using a Novel Marker." Gut.Burkitt D, Trowell H. (1975). Refined Carbohydrate Foods and Disease.This podcast is brought to you in collaboration with the British Society of Lifestyle Medicine.Disclaimer:The content in this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your doctor or qualified healthcare provider. Never disregard professional medical advice or delay in seeking it because of something you have heard on this podcast.

I'm thrilled to bring you this conversation about a breakthrough in male fertility diagnostics that's been literally hiding in plain site. In this episode, I'm joined by Dr. Jeff Lysiak, PhD, co-founder and Chief Science Officer at PS Fertility, to discuss phosphatidylserine (PS) and how this critical molecule on sperm is revolutionizing how we diagnose male infertility. Jeff shares the fascinating story of how his research at the University of Virginia led to discovering that PS on the surface of sperm is essential for fertilization and how traditional semen analysis completely misses this vital piece of the puzzle. Read the full show notes on my website.  This episode addresses a frustration I've experienced for years in my practice: couples with "normal" semen analysis results who still have trouble when it comes to trying to conceive. Research shows that 20-30% of men with normal basic semen analysis could still be infertile, and we've had no way to identify them, until now.  In this episode, we cover: What phosphatidylserine (PS) is and why it's critical for sperm to fuse with and fertilize an egg The major limitations of standard semen analysis (count, motility, morphology) and why 20-30% of men with "normal" results may still be infertile How the PS Detect test works using flow cytometry to assess over 10,000 sperm per sample The connection between varicocele and low PS scores—and how varicocelectomy surgery can restore PS levels to normal ranges When the PS test should be ordered in a fertility workup and what to do if scores are low Early data showing over 30% of men seeking fertility treatment have low PS scores, including those with normal semen analysis How this test can prevent women from undergoing unnecessary treatments when the male factor is undiagnosed Resources: PS Fertility website: psfertility.com PS Detect at-home test kit Nature Communications publication on phosphatidylserine and fertilization Dr. Aimee's Supplement Stack The TUSHY Method OVANAD+ by Theralogix. Use code EGG. Would you like to learn more about IVF?Click here to join Dr. Aimee for The IVF Class. The next live class call is on Monday, April 20, 2026 at 4pm PST, where Dr. Aimee will explain IVF and there will be time to ask her your questions live on Zoom.   Dr. Aimee Eyvazzadeh is one of America's most well known fertility doctors. Her success rate at baby-making is what gives future parents hope when all hope is lost. She pioneered the TUSHY Method and BALLS Method to decrease your time to pregnancy. Learn more about the TUSHY Method and find a wealth of fertility resources at www.draimee.org. Other ways to connect: Subscribe to my YouTube channel for more fertility tips Join Egg Whisperer School Subscribe to the newsletter to get updates   Keywords: male infertility, phosphatidylserine, PS score, PS Detect, male fertility testing, semen analysis limitations, sperm function, fertilization competence, varicocele, unexplained infertility, IUI success rates, male factor infertility, reproductive urology, Jeff Lysiak, PS Fertility, sperm egg fusion, fertility diagnostics, at-home sperm test, idiopathic male infertility, fertility workup, egg whisperer show, Dr. Aimee

Výtah Respektu: „Jaderná energie je klíčem k dosažení evropské energetické nezávislosti", řekl v úterý na pařížském summitu francouzský prezident Emmanuel Macron. Na podporu jádra se vyslovil i slovenský premiér Robert Fico. A třeba šéfka Evropské komise Ursula von der Leyen označila evropský odklon od jaderné energie z nedávné minulosti za chybu. Přitom jen před pár dny Respekt publikoval text, který začíná větou: „Čím blíže žijí lidé k jaderné elektrárně, tím vyšší může být riziko, že zemřou na rakovinu," s tím, že to naznačuje studie vědců z Harvardovy univerzity, která mapovala jednotlivé okresy USA, a která byla zveřejněna koncem února v časopise Nature Communications. Čím se poznatky liší od těch, které jsme měli doposud? Jak autoři studie reagují na kritiku? A vylučuje to výroky zmíněných politiků a političek? I o tom mluví ve středeční epizodě Martin Uhlíř.

It's In the News, a look at the top headlines and stories in the diabetes community. This week's top stories: Stem Cell Islet Therapy Partnership, "Lyla's Law" Type 1 Testing Debate, Patient-Led Insulin Dosing for Gestational Diabetes, $3 Semaglutide Manufacturing, FDA GLP-1 Compounding Crackdown Announcing Community Commericals! Learn how to get your message on the show here. Learn more about studies and research at Thrivable here Please visit our Sponsors & Partners - they help make the show possible! Omnipod - Simplify Life All about Dexcom  All about VIVI Cap to protect your insulin from extreme temperatures The best way to keep up with Stacey and the show is by signing up for our weekly newsletter: Sign up for our newsletter here Here's where to find us: Facebook (Group) Facebook (Page) Instagram Check out Stacey's books! Learn more about everything at our home page www.diabetes-connections.com  transcript with links:  Welcome! I'm your host Stacey Simms and this is an In The News episode.. where we bringing you the top diabetes stories and headlines happening now. A reminder that you can find the sources and links and a transcript and more info for every story mentioned here in the show notes. I am definitely feeling better – that lingering cold is gone – but whew still recovering from non stop travel for the past five weeks. I have a great strech of time her at home, then going to Vegas for Brekathorugh T1D at the end of the month and we have two club 1921 events in April – Atlanta and Philly. Before we jump into the news – I need your community commercials! These have been a lot of fun, I announced them late last year – your voice on the show. All the instructions it's very easy in the show notes. Okay.. our top story this week: XX A biotech company developing stem-cell treatments for type 1 diabetes has announced a new research partnership aimed at improving the survival of transplanted insulin-producing cells. NewcelX, a clinical-stage company based in Switzerland, said it will work with Eledon Pharmaceuticals to study a combination approach. The goal is to help transplanted cells survive longer in the body by reducing the immune response that often leads to transplant rejection. If successful, the strategy could support longer-lasting islet cell replacement and move the therapy closer to becoming a functional treatment for people with type 1 diabetes. However, the companies have not yet released any safety or effectiveness data on the combination treatment, and financial details of the partnership were not disclosed. The research agreement is focused on exploring whether combining stem-cell-derived islets with targeted immune therapy can lead to longer-lasting cell transplants and improved outcomes for people with type 1 diabetes. https://www.stocktitan.net/news/ELDN/newcel-x-announces-strategic-collaboration-with-eledon-d10l1vqdofls.html XX Debate this week in the UK on whether testing for type 1 diabetes should become mandatory when children present with symptoms. The Westminster Hall debate, scheduled for 9 March, will consider calls for routine testing of babies, toddlers and young children who show signs associated with the condition. It follows a petition backing the move, dubbed 'Lyla's Law', which passed 121,000 signatures in December 2025. The campaign was launched by John Story after his two-year-old daughter, Lyla, died from diabetic ketoacidosis (DKA) on 3 May 2025, 16 hours after being diagnosed with tonsillitis. https://www.nursinginpractice.com/clinical/diabetes-and-endocrinology/diabetes-community-urged-to-call-on-mps-to-attend-lylas-law-debate/ XX     A new study suggests that people with gestational diabetes who adjust their own insulin doses may reach healthy blood sugar levels faster than those whose doses are adjusted by clinicians. Half of the participants were assigned to adjust their own insulin doses using a simple rule: increase the dose by two units if fasting blood glucose was above 95 mg/dL, decrease it by two units if it dropped below 70 mg/dL, and keep the same dose if levels fell in between. The other half had their insulin adjusted by clinicians through weekly reviews. By the end of pregnancy, both groups had similar average fasting glucose levels before delivery: about 89 mg/dL in the patient-led group and 90 mg/dL in the clinician-led group. However, those adjusting their own insulin reached their blood sugar targets more quickly, averaging 1.8 weeks compared with 2.5 weeks for those managed by clinicians. The study also found lower risks of certain complications among the patient-led group. https://www.medscape.com/viewarticle/self-insulin-dosing-leads-control-gestational-diabetes-2026a1000729 XX   A blockbuster anti-obesity and diabetes drug could cost as little as $3 per month to manufacture once it goes off patent later this month, researchers said Friday, providing a major opportunity to boost health in low and middle-income countries.   Semaglutide, the active molecule in Novo Nordisk's Ozempic and Wegovy will lose patent protection in countries such as Brazil, China, and India later this month, and researchers identified 150 countries where it was never patented. These researchers estimated it will cost as little as $3 to produce a month's supply of semaglutide, which in its branded form sells for around $200 a month in the United States. Another of the study's authors, Professor Francois Venter at the University of Witwatersrand in South Africa, said drugs to treat HIV, TB, malaria, and hepatitis are now available at prices close to production costs but still sufficient for generic manufacturers to operate. https://www.sciencealert.com/weight-loss-drugs-could-cost-just-3-a-month-to-make-as-patents-end XX Here in the US the FDA is stepping up its efforts to combat widespread GLP-1 drug compounding. In its latest offensive, the agency has unleashed a fresh set of 30 warning letters targeting telehealth companies it says make "false or misleading" claims about compounded versions of popular obesity drugs. The FDA says Compounded drugs can be important for overcoming shortages or meeting unique patient needs—but compounders should not try to compound drugs in a way that circumvents FDA's approval process." https://www.fiercepharma.com/pharma/fda-ramps-crackdown-glp-1-drug-compounders-fresh-batch-30-warning-letters XX   Check your infusion sets for an issue: Unomedical, a subsidiary of Convatec and a supplier of insulin infusion sets to diabetes tech firms, has received a warning letter from the FDA. Inspectors raised concerns with leaking infusion sets, following a regulatory assessment of Unomedical's facility in Reynosa, Mexico, last summer. Unomedical supplies infusion sets to insulin pump makers including Medtronic, Tandem Diabetes Care and Beta Bionics. In a Feb. 3 statement, Convatec said the letter focuses on reporting procedures and quality protocols and does not place restrictions on producing, marketing or distributing any of Unomedical's products.  Unomedical told the FDA in its responses that it plans to conduct a retrospective review of complaints involving serious injury or death by January and conduct additional training on complaint handling by May.   https://www.medtechdive.com/news/fda-warns-insulin-infusion-set-maker-unomedical-over-leaks-mishandled-comp/813503/ XX Nearly four in ten people with type 2 diabetes do not take their medications as prescribed, according to a new research review published in Diabetologia in November 2025.   Researchers examined existing studies on medication adherence, including how often patients miss doses, why it happens, and what strategies may help. They estimated that about 38% of patients with type 2 diabetes are not fully adherent to their medications.   Adherence rates vary depending on the type of medication. About 63% to 68% of patients take oral glucose-lowering drugs as directed, while adherence drops to 43% to 54% for injectable GLP-1 medications and 41% to 64% for insulin.   Poor adherence can lead to serious consequences. One retrospective study cited in the review found that patients who consistently took their glucose-lowering medications had a 31% lower risk of hospitalization or emergency department visits.   The review also highlighted ways to improve adherence. Simplifying medication routines can help, such as using fixed-dose combination pills, which combine multiple drugs into a single tablet. Studies show these combinations are linked to better adherence and improved blood sugar control.   Pharmacists can also play an important role by providing education, reviewing medications, setting up reminders, and helping patients organize their treatment plans. The researchers noted that support should be tailored to each patient. Older adults may benefit from simpler systems and caregiver support, while younger patients may respond better to digital tools like app-based reminders.   The authors also found that measuring adherence is challenging and recommend using multiple methods, such as pharmacy records, patient interviews, and objective tests when possible.   Overall, the review concludes that personalized, multi-step approaches lasting at least three months are most effective in helping people with type 2 diabetes stay on track with their medications. https://www.pharmacytimes.com/view/type-2-diabetes-medication-adherence-rates-remain-low-and-pharmacists-can-help XX New clinical trial shows metformin does not directly reverse insulin resistance in people with type 1 diabetes. Instead, it lowers the total amount of insulin required to keep blood glucose levels within the recommended range. The findings, published in Nature Communications, challenge long-held assumptions about how metformin works in type 1 diabetes. The results may help physicians refine treatment strategies and reduce the daily demands placed on people who rely solely on insulin therapy. "Insulin resistance is a growing problem in type 1 diabetes. Not only does it make regulating blood sugar levels difficult, but it is an underappreciated risk factor for heart disease, which is one of the biggest causes of health complications and deaths in those with type 1 diabetes," says Dr. Jennifer Snaith, endocrinologist and co-lead of the study.   https://scitechdaily.com/groundbreaking-trial-reveals-unexpected-benefit-of-metformin-in-type-1-diabetes/   Tech news ahead, including updates from Sensonics, Dexcom & Tandem.. right after this…. Back ot the wnews.. XX Sensonics shares that it's secured FDA investigational device exemption (IDE) for its self-powered, battery-enabled Gemini sensor. It enrolled the first patients in the IDE trial and expects to complete that in the second half of 2026. Gemini builds on the implanted CGM to put the transmitter under the skin as well as the sensor. https://www.drugdeliverybusiness.com/senseonics-q4-2025-ide-gemini-cgm/ XX Medtronic Diabetes is now officially MiniMid, a stand alone public company. Medtronic  acquired MiniMed 25 years ago announed last May that it would spin its diabetes business off. In their statement the company points out that MiniMed is the only diabetes tech company to sell both insulin pumps and continuous glucose monitors.   https://www.investing.com/news/stock-market-news/medtronics-diabetes-unit-minimed-valued-at-53-billion-as-shares-fall-in-nasdaq-debut-4547518 XX Kevin Sayer heads back to Dexcom.. The former CEO is back in his position as executive chair of the Board, he'd stepped away for a medical leave. Dexcom (Nasdaq:DXCM) announced today in an SEC filing that former CEO Kevin Sayer has returned from his leave of absence. Sayer's return to the board comes just days after Dexcom announced a new board member. Last week, the company announced that it added Google SVP, Platforms and Devices, Rick Osterloh, to its board as well.     https://www.drugdeliverybusiness.com/kevin-sayer-returns-dexcom-board-chair/ SAN DIEGO - DexCom, Inc. (NASDAQ:DXCM) announced the appointment of Rick Osterloh to its Board of Directors, effective today, according to a press release statement.   Osterloh serves as Senior Vice President, Platforms & Devices at Google, where he oversees Android, Google Play, Chrome, and Google's hardware portfolio including Pixel phones, Google Nest devices, and Fitbit wearables. He has held this position since 2016.   https://www.investing.com/news/company-news/dexcom-appoints-google-executive-rick-osterloh-to-board-93CH-4529662 XX Sequel Med Tech announced broad national availability of its twiist™ Automated Insulin Delivery (AID) System powered by Tidepool. After U.S. FDA clearance in 2024 and a controlled launch to optimize the twiist experience, the system is now fully available nationwide. The release says: Built on Sequel's proprietary iiSure™ Technology, the system enables earlier detection of delivery issues, alerting users to blockages up to nine times faster than other AID systems1, potentially reducing the risk of unexplained high glucose and giving you time to take action before experiencing severe high blood sugar or DKA2. Designed to expand access to automated insulin delivery, twiist is available through pharmacy channels with a flexible access model, XX Tandem Diabetes Care's Mobi automated insulin delivery system is now available with Android devices. In November, Tandem announced that it received FDA approval for the Android version of its Mobi mobile app. The pump, which pairs with Tandem's Control-IQ+ algorithm, previously worked with iOS software. At the time of the clearance, it said it would commence a limited rollout before the full launch — now underway — this year.   Tandem launched Mobi in the U.S. in February 2024. It initially received FDA clearance for people with diabetes ages six and up in July 2023. The system then received expanded clearance for pediatric indications in April 2024, then later won CE mark in May 2025.   Mobi features a 200-unit insulin cartridge and an on-pump button to provide an alternative to phone control for insulin boluses. It comes in at less than half the size of the flagship Tandem pump system, the t:slim X2 pump. Mobi can fit in a coin pocket, clip to clothing or go on the body with an adhesive sleeve. https://www.drugdeliverybusiness.com/tandem-diabetes-care-launches-mobi-android/

Podcast Host and Interviewee: Shahad Abdulsahib, PhD Candidate, UT Health San Antonio Podcast Description: Shahad Abdulsahib discusses a recent Phase 1 clinical trial on Rhenium-186 nanoliposome therapy for recurrent glioma, published in Nature Communications in March 2025.

Astronomy Daily — S05E55 | 6 March 2026 Six stories today covering planetary defence, a cosmic laser record, a solar superstorm on Mars, space debris pollution, a mystery satellite launch, and the most charming farming experiment you'll hear about all year.   Stories This Episode 1. Asteroid 2024 YR4 — Moon Impact Officially Ruled Out NASA has confirmed, using the James Webb Space Telescope, that infamous asteroid 2024 YR4 will not hit the Moon in 2032. The space rock — once the most dangerous asteroid identified in two decades — will instead pass the Moon at a distance of around 13,200 miles. It previously held a 4% lunar impact probability, now fully eliminated thanks to Webb's extraordinary sensitivity pushing it to the limits of what the telescope can observe.   2. MeerKAT Detects Cosmic 'Gigalaser' 8 Billion Light-Years Away South Africa's MeerKAT radio telescope has spotted the most distant hydroxyl megamaser ever detected — a natural 'space laser' in a galaxy undergoing a violent collision more than 8 billion light-years away. The signal is so powerful it qualifies as a gigamaser. Adding to the serendipity, the signal was further amplified by a foreground galaxy acting as a gravitational lens on its 8-billion-year journey to Earth. The discovery points toward the future capability of the Square Kilometre Array (SKA).   3. ESA's Mars Orbiters Record Solar Superstorm Hitting Mars A new Nature Communications study reveals what happened when the record-breaking May 2024 solar superstorm hit Mars. ESA's Mars Express and ExoMars Trace Gas Orbiter recorded unprecedented electron density spikes in the Martian upper atmosphere — up to 278% above normal — and both spacecraft experienced computer glitches from the energetic particles. The study uses a novel spacecraft-to-spacecraft radio occultation technique and highlights how Mars's lack of a global magnetic field leaves it vulnerable to solar events in ways that Earth is not.   4. SpaceX Falcon 9 Re-entry Directly Linked to Atmospheric Lithium Plume For the first time, scientists have directly tied a specific rocket re-entry to a measurable atmospheric pollution event. Researchers at the Leibniz Institute for Atmospheric Physics detected a tenfold spike in lithium vapour in the upper atmosphere — from 3 to 31 atoms per cubic centimetre — in the hours following the uncontrolled re-entry of a Falcon 9 upper stage off Ireland in February 2025. Eight thousand backward atmospheric simulations confirmed the connection. Published in Communications Earth & Environment, the paper raises important questions about the growing chemical footprint of the commercial space industry.   5. Rocket Lab Launches Mystery Satellite — 'Insight at Speed is a Friend Indeed' Rocket Lab completed its 83rd Electron launch from New Zealand, deploying a single satellite for a confidential commercial customer to an orbit 470 km above Earth. The company announced the mission just hours before liftoff, offering no further details on the customer or the payload's purpose.   6. Scientists Grow Chickpeas in Simulated Moon Dirt for First Time Researchers at the University of Texas at Austin and Texas A&M University have successfully grown and harvested chickpeas in simulated lunar regolith — the first time this has ever been achieved. Using a combination of vermicompost (worm castings) and arbuscular mycorrhizal fungi to condition the otherwise toxic, sterile moon dirt, the team produced flowering, seed-bearing plants in soil mixtures of up to 75% regolith simulant. The chickpeas have not yet been cleared for eating pending metal accumulation testing — but the team's goal of 'moon hummus' is, apparently, very much alive.   Find Us:  astronomydaily.io  |  @AstroDailyPod on all platforms Subscribe & Review:  Apple Podcasts · Spotify · YouTube · everywhere you listenBecome a supporter of this podcast: https://www.spreaker.com/podcast/astronomy-daily-space-news-updates--5648921/support.Sponsor Details:Ensure your online privacy by using NordVPN. To get our special listener deal and save a lot of money, visit www.bitesz.com/nordvpn. You'll be glad you did!Become a supporter of Astronomy Daily by joining our Supporters Club. Commercial free episodes daily are only a click way... Click HereThis episode includes AI-generated content.

A study published in Nature Communications, published Feb 19, 2026, found that “pregnancy physically alters a woman's brain, with a second pregnancy bringing even more profound effects.” The researchers “performed brain scans on 110 women. Some were first-time mothers, others second-time moms, and some nulliparous women. Results showed that during a first pregnancy, the greatest changes occur in the structure and activity of the ‘default mode network' – the brain system responsible for self-reflection and mind wandering. Are these changes bad? Are they associated with long term hard? Are they adaptive? It's a complex question, with real answers. Listen in for details.1. Straathof, M., Halmans, S., Pouwels, P.J.W. et al. The effects of a second pregnancy on women's brain structure and function. Nat Commun 17, 1495 (2026). https://doi.org/10.1038/s41467-026-69370-82. de Lange AG, Kaufmann T, van der Meer D, et al. Population-Based Neuroimaging Reveals Traces of Childbirth in the Maternal Brain. Proceedings of the National Academy of Sciences of the United States of America. 2019.3. Aleknaviciute J, Evans TE, Aribas E, et al.)Long-Term Association of Pregnancy and Maternal Brain Structure: The Rotterdam Study. European Journal of Epidemiology. 2022.4. Jung JH, Lee GW, Lee JH, et al. Multiparity, Brain Atrophy, and Cognitive Decline. Frontiers in Aging Neuroscience. 2020.5. Hu A, Xiong L, Wei H, et al. Association of Menarche, Menopause, and Reproductive History With Cognitive Performance in Older US Women: A Cross-Sectional Study From NHANES 2011-2014. BMC Public Health. 2025.6. Orchard ER, Ward PGD, Sforazzini F, et al. Relationship Between Parenthood and Cortical Thickness in Late Adulthood. PloS One. 20207. Hoekzema E, Barba-Müller E, Pozzobon C, et al. Pregnancy Leads to Long-Lasting Changes in Human Brain Structure. Nature Neuroscience. 2017.8. de Lange AG, Barth C, Kaufmann T, et al. Women's Brain Aging: Effects of Sex-Hormone Exposure, Pregnancies, and Genetic Risk for Alzheimer's Disease. Human Brain Mapping. 2020.Visit our SPONSOR's LINK to learn more about the Hemorrhage view CS Drape: https://www.perspectivemedical.org/

Esta semana en H2 Intereconomía, las noticias sobre hidrógeno han mostrado un impulso significativo del sector en España. Iberdrola ha activado una nueva fase de su estrategia de hidrógeno verde, reforzando su papel en la descarbonización industrial mediante inversiones, contratos y consolidación de infraestructuras. Avalon Renovables ha elevado la inversión de su planta ‘La Joya H2' en Antequera hasta 1.200 millones de euros, buscando convertir la zona en un polo estratégico de hidrógeno verde. En Euskadi, ya se impulsan 65 proyectos con objetivos ambiciosos de potencia instalada y producción de combustibles sintéticos para 2030. Además, MASPV y Shanghai Shaanyao presentan proyectos conjuntos por más de 1.000 millones de euros, mientras que la fundación CIM UPC ha logrado producir hidrógeno verde mediante impresión 3D, abriendo nuevas vías en manufactura energética. Un estudio publicado en Nature Communications también ha revelado que el núcleo terrestre podría contener hasta 45 veces más hidrógeno que los océanos, reavivando el debate sobre el origen y la distribución del agua en el planeta. Javier Brey, presidente de la Asociación Española del Hidrógeno, ha explicado que el European Hydrogen Energy Conference (EHEC) es un congreso bianual de gran relevancia internacional, organizado desde 2005 para reunir a expertos, empresas e instituciones de más de 50 países. La próxima edición en Sevilla se celebrará en el Palacio de Congresos FIBES y contará con cerca de 2.000 asistentes, sesiones plenarias, paralelas y una amplia zona expositiva. El evento, como ha señalado Javier Brey, integra toda la cadena de valor del hidrógeno, desde la investigación y desarrollo hasta la industria y los reguladores, ofreciendo un foro único para la innovación y la colaboración internacional. Sobre la participación industrial, Brey resaltó que la presencia de empresas es fundamental, con 111 stands, pabellones nacionales e internacionales y exposición de vehículos y equipamiento de hidrógeno. Esta integración de industria y ciencia convierte al EHEC en un congreso que combina aspectos científicos, tecnológicos, industriales y políticos, reforzando la posición de España como líder en producción de hidrógeno verde y en desarrollo de tecnología asociada. Asimismo, el evento permite a empresas y académicos interactuar directamente y mostrar avances, proyectos y soluciones innovadoras en un entorno de colaboración abierto. Brey ha indicado que el sector del Hidrógeno se encuentra en un proceso de consolidación: aunque la cartera total de proyectos ha disminuido un 14% entre 2024 y 2025, los proyectos en operación, construcción o con cierre financiero son más maduros y viables. Destacó también el papel del apoyo institucional, especialmente de la Junta de Andalucía y del Ayuntamiento de Sevilla, que han respaldado la candidatura de la ciudad como sede del congreso, proporcionando apoyo financiero e institucional. Brey subrayó que lo que el sector necesita ahora es estabilidad regulatoria y seguridad jurídica, además de continuar fomentando la innovación y la colaboración a través de eventos como el EHEC.

Shahad Abdulsahib discusses the findings of a recent paper, entitled "Transcriptional regulation of protein synthesis by mediator kinase represents a therapeutic vulnerability in MYC-driven medulloblastoma", which was published in Nature Communications in December 2025.

L'excès de cholestérol, ou hypercholestérolémie, est un défi majeur pour la santé cardiovasculaire, augmentant les risques d'infarctus et d'AVC. Si l'on sait que l'alimentation est un levier clé sur le long terme, une étude récente relayée par le Journal des Femmes révèle qu'un aliment spécifique peut générer des résultats spectaculaires en un temps record : le flocon d'avoine.Une efficacité prouvée en 48 heuresL'étude, publiée dans la revue scientifique Nature Communications, s'est penchée sur des personnes souffrant de syndrome métabolique (associant obésité, hypertension et cholestérol). Les chercheurs ont testé un régime intensif de deux jours comprenant une consommation élevée d'avoine (environ 100g consommés trois fois par jour). Les résultats sont sans appel : en seulement 48 heures, une baisse significative du "mauvais" cholestérol (LDL) et du cholestérol total a été mesurée par rapport au groupe témoin.Le secret : l'interaction avec le microbiotePourquoi une telle rapidité ? L'explication ne réside pas uniquement dans l'avoine elle-même, mais dans la manière dont notre corps la transforme. Le flocon d'avoine est riche en fibres spécifiques qui, une fois ingérées, interagissent avec les bactéries de notre intestin.Le microbiote intestinal transforme ces fibres en molécules bénéfiques qui passent ensuite dans le sang. Parmi elles, l'acide férulique et l'acide dihydroférulique jouent un rôle protecteur crucial. L'étude démontre que plus l'apport en avoine est important, plus la production de ces substances par les bactéries intestinales est rapide et massive. Ce sont ces composés qui agissent comme des agents régulateurs, permettant de faire chuter les niveaux de lipides circulants de manière quasi immédiate.Comment l'intégrer au quotidien ?Au-delà de cette "cure" express de 48 heures, l'avoine reste un allié précieux sur la durée. L'avantage du flocon d'avoine est sa grande polyvalence. On peut le consommer :Au petit-déjeuner : sous forme de porridge, mélangé à un yaourt ou dans un smoothie.En cuisine salée : pour épaissir une soupe, lier des boulettes de viande ou confectionner des galettes végétales.En pâtisserie : en remplacement partiel de la farine dans des gâteaux ou des pains maison.En résumé, le flocon d'avoine n'est pas qu'un simple aliment santé ; c'est un véritable catalyseur biologique qui, grâce à l'action de notre microbiote, offre une solution naturelle, rapide et accessible pour protéger nos artères et notre cœur. Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

Intermittent fasting is often promoted as a simple solution for weight loss, but most of the research behind it has been done in men. In this episode, I break down one of the few women-specific trials on time-restricted eating: Flexible time-restricted eating and aerobic exercise in middle-aged women (Nature Communications, 2025). You can read the paper here: https://www.nature.com/articles/s41467-025-65678-z This study looked at middle-aged women with overweight or obesity and found that an 8-hour eating window reduced fat mass, with the greatest improvements seen when time-restricted eating was combined with exercise. In this episode, we cover: Why skipping breakfast often backfires for stressed or cycling women Why cortisol, sleep, and total intake matter more than fasting longer Why I prefer time-restricted eating over strict 16-hour fasts How a 10–12 hour overnight fast may support fat metabolism A more sustainable, physiology-first approach to weight loss If you want a more sustainable, physiology-first approach to weight loss as a woman, this episode will help you rethink timing, stress, and structure. Notes: Join Flourish - my small group programme focused on weight loss here

In this episode of SpaceTime, we dive into groundbreaking research revealing the true composition of the Earth's core, explore new insights into solar neutrinos, and uncover the complexities of Martian volcanoes.Earth's Core Contains Vast Hydrogen ReservoirA recent study published in Nature Communications indicates that Earth's core may hold up to 45 oceans' worth of hydrogen, challenging the long-held belief that water on our planet primarily came from asteroids and comets. Utilizing advanced laboratory techniques, researchers simulated the extreme conditions of the core to uncover its surprising hydrogen content, suggesting a significant internal source of water far beyond previous estimates.Neutrinos from the Sun's CoreA new dark matter experiment has successfully detected neutrinos originating from the Sun's core, marking a significant milestone in our understanding of these elusive particles. The LZ experiment at the Sanford Underground Research Facility captured signals from Brian 8 solar neutrinos, providing valuable data on solar processes and setting new limits for dark matter research. This breakthrough highlights the potential of neutrino studies in unraveling the mysteries of both dark matter and stellar dynamics.Complexity of Martian VolcanoesNew findings published in Geology reveal that young Martian volcanoes are far more complex than previously thought. Researchers have discovered that these volcanoes were shaped by long-lasting and evolving magma systems rather than single eruptions. By analyzing surface features and mineral compositions from orbit, scientists have reconstructed the intricate eruptive history of these volcanic systems, shedding light on the Red Planet's geological past.www.spacetimewithstuartgary.com✍️ Episode ReferencesNature Communications, GeologyBecome a supporter of this podcast: https://www.spreaker.com/podcast/spacetime-with-stuart-gary--2458531/support.(00:00:00) New study reveals Earth's core may contain vast amounts of hydrogen(00:08:30) Breakthrough in solar neutrino detection from the Sun's core(00:16:45) Insights into the complex eruptive history of Martian volcanoes(00:25:00) Science report: The link between caffeine consumption and reduced dementia risk(00:32:15) Study on the frequency of passionate love experiences in humans

In this episode of the Epigenetics Podcast, we talked with Srinjan Basu from Imperial College London to talk about his work on how chromatin architecture and epigenetic mechanisms orchestrate developmental gene expression programs. We begin by exploring Dr. Basu's early work at Harvard which involved pioneering Raman-based label-free imaging, allowing the study of chromatin dynamics in live tissue. Here, he tackles technical challenges faced in visualizing DNA interactions, emphasizing the shift from 2D to 3D analysis and the importance of real-time observation of chromatin behavior under various conditions. This segues into his groundbreaking research on single transcription factors interacting with chromatin, revealing subtle but significant changes in the dynamics of gene regulation. We transition into the complexities of chromatin architecture as Dr. Basu recounts his efforts in mapping the entire mouse genome in single pluripotent cells, unearthing unexpected heterogeneity among cells. This heterogeneity raises intriguing questions about its impact on cellular function, prompting ongoing investigations into chromatin dynamics and the role of remodeling complexes like NuRD in cell fate transitions. Dr. Basu elucidates how recent studies have begun to bridge the gaps in understanding how transcription factors and chromatin dynamics interact during cellular decisions, particularly emphasizing the influence of mechanical signals and the intrinsic properties of cells. His research underscores the idea that stem cells undergo a preparatory phase for differentiation, highlighting the critical balance of intrinsic and extrinsic factors that govern genetic expression and cellular outcomes. We also talk about Dr. Basu's current research trajectory, focusing on enhancing imaging techniques to study gene dynamics in tissue contexts relevant to developmental biology and disease states. He illustrates a vision for future projects that integrate advanced imaging tools to investigate transcription factor dynamics and chromatin interactions in live cells and embryos, furthering the understanding of decision-making processes in cellular contexts. References Stevens TJ, Lando D, Basu S, et al. 3D structures of individual mammalian genomes studied by single-cell Hi-C. Nature. 2017 Apr;544(7648):59-64. DOI: 10.1038/nature21429. PMID: 28289288; PMCID: PMC5385134. Basu S, Needham LM, Lando D, et al. FRET-enhanced photostability allows improved single-molecule tracking of proteins and protein complexes in live mammalian cells. Nature Communications. 2018 Jun;9(1):2520. DOI: 10.1038/s41467-018-04486-0. PMID: 29955052; PMCID: PMC6023872. Related Episodes Advanced Optical Imaging in 3D Nuclear Organisation (Lothar Schermelleh) Analysis of 3D Chromatin Structure Using Super-Resolution Imaging (Alistair Boettiger) Single-Molecule Imaging of the Epigenome (Efrat Shema) Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com

In today's episode of Astronomy Daily, Anna and Avery cover five major stories from across the cosmos. SpaceX Crew-12 is targeting Thursday February 12th for launch to the International Space Station, after weather pushed back the Wednesday window. Meet the international crew of four and find out why this mission will run longer than usual. Our Sun has been active overnight, with sunspot region AR4366 firing off four M-class flares including an M2.8 that triggered a radio blackout over the Pacific. We look at what this means for space weather and aurora watchers. A stunning new study from Penn State, published in PNAS, has rewritten how scientists think amino acids formed in asteroid Bennu — and the implications for where life's ingredients can arise in the universe are profound. Italian scientists have confirmed the first lava tube on Venus, using 30-year-old radar data from NASA's Magellan mission. The structure is larger than any lava tube found on Earth, the Moon, or Mars. And finally — could coal be the key to finding advanced alien civilisations? A provocative new paper in the International Journal of Astrobiology makes the case. All stories sourced from NASA, Nature Communications, PNAS, and Phys.org. Links below. Source Links •       Crew-12 weather delay: nasa.gov/blogs/spacestation •       NSF launch preview: nasaspaceflight.com/2026/02/launch-preview-020926 •       Bennu amino acids (PNAS): doi.org/10.1073/pnas.2517723123 •       Venus lava tube (Nature Communications): doi.org/10.1038/s41467-026-68643-6 •       Aliens and coal: phys.org/news/2026-02-advanced-aliens-exoplanets-large-coal.html •       Solar activity: earthsky.org/sun/sun-news-activity-solar-flare-cme-aurora-updates Chapters / Timestamps (approximate) •       00:00 — Cold Open •       01:00 — Story 1: SpaceX Crew-12 Weather Delay •       05:00 — Story 2: Solar Flare Activity AR4366 •       07:30 — Story 3: Asteroid Bennu & Amino Acid Origins •       10:30 — Story 4: Venus Lava Tube Discovery •       13:30 — Story 5: Alien Civilisations & Coal Deposits •       17:00 — CloseBecome a supporter of this podcast: https://www.spreaker.com/podcast/astronomy-daily-space-news-updates--5648921/support.Sponsor Details:Ensure your online privacy by using NordVPN. To get our special listener deal and save a lot of money, visit www.bitesz.com/nordvpn. You'll be glad you did!Become a supporter of Astronomy Daily by joining our Supporters Club. Commercial free episodes daily are only a click way... Click HereThis episode includes AI-generated content.

Superpowers for Good should not be considered investment advice. Seek counsel before making investment decisions. When you purchase an item, launch a campaign or create an investment account after clicking a link here, we may earn a fee. Engage to support our work.Watch the show on television by downloading the e360tv channel app to your Roku, LG or AmazonFireTV. You can also see it on YouTube.Devin: What is your superpower?Eugene: Staying focused on a North Star.Eugene Chan, CEO and founder of rHEALTH, has taken blood diagnostics to new heights—literally. His innovative technology, capable of analyzing dozens of biomarkers from a single drop of blood, was tested aboard the International Space Station (ISS). In today's episode, Eugene shared the remarkable journey of rHEALTH, from competing with top companies for a NASA partnership to launching its device into space.What sets rHEALTH apart is its proven reliability in extreme conditions, including the zero-gravity environment of space. Eugene explained, “We tested this technology on the International Space Station with astronaut Samantha Cristoforetti, who operated the device and obtained precise values from single drops of sample. They did the analysis using our device and got absolutely the right answers.” This achievement underlines the robustness and accuracy of rHEALTH's technology, qualities that distinguish it from other attempts at single-drop blood diagnostics.Unlike Theranos, which famously failed to deliver on similar promises, rHEALTH's technology has been rigorously vetted. Eugene highlighted the grueling process of earning NASA's trust. “To be the one company selected to demonstrate our novel technology on the ISS was a huge undertaking,” he said. He recounted the intense competition and NASA's exacting standards, which included testing the device's functionality during zero-gravity parabolic flights.Now, Eugene and his team are bringing this groundbreaking technology to the public with a regulated crowdfunding campaign on StartEngine. “You don't have to be a Silicon Valley elite or a Boston venture capitalist to participate,” I noted during the episode. With this campaign, everyday investors have the opportunity to support a proven technology poised to revolutionize healthcare.The implications of rHEALTH's success are profound. If it works in space, it can work in remote clinics, underserved communities, and even in people's homes. This technology has the potential to make diagnostics more accessible, empowering individuals to take control of their health.Eugene's vision, combined with rHEALTH's proven track record, makes this an exciting investment opportunity. Visit StartEngine to learn more and become part of this revolutionary journey.tl;dr:Eugene Chan shared how rHEALTH's diagnostic technology was tested and proven aboard the International Space Station.He explained the rigorous process of competing with other companies to secure NASA's trust.rHEALTH's crowdfunding campaign on StartEngine makes investing in this revolutionary technology accessible to all.Eugene highlighted the importance of his North Star: improving human health with innovative solutions.He shared advice on maintaining focus and using challenges as opportunities to achieve big goals.How to Develop Staying Focused on a North Star As a SuperpowerEugene's superpower is his ability to maintain a relentless focus on his “North Star”—the overarching goal of improving human health. As he explained, “The North Star has always been to improve the human condition and help us improve human health.” For Eugene, this guiding principle has driven his work through challenges, from competing for NASA's attention to developing groundbreaking diagnostic technology.One illustrative story of this superpower came during a pivotal moment in Eugene's career. While competing in the XPRIZE competition, he found himself grappling with a flawed prototype. It was during this time, sitting at his wife's bedside after the birth of their child, that the concept for rHEALTH's current device was born. Combining the pressure of the competition, the inspiration of his newborn daughter, and his unwavering focus on creating a robust solution, Eugene developed the technology that would later achieve success in space.Eugene also shared actionable tips for developing this superpower:Identify your personal North Star—a goal or mission that deeply resonates with you.Let that North Star guide your decisions, especially during challenging times.Stay committed to your mission, even when facing setbacks or obstacles.Use external pressures, like deadlines or competitions, to fuel innovation and progress.By following Eugene's example and advice, you can make staying focused on a North Star a skill. With practice and effort, you could make it a superpower that enables you to do more good in the world.Remember, however, that research into success suggests that building on your own superpowers is more important than creating new ones or overcoming weaknesses. You do you!Guest ProfileEugene Chan (he/him):CEO, Founder, rHEALTHAbout rHEALTH: rHEALTH has worked with NASA to develop a miniaturized diagnostic test system to keep astronauts healthy on the way to Mars. We have successfully tested this onboard the International Space Station and published the results in Nature Communications, demonstrating results from blood in minutes in extreme environments. The technology shrinks a central clinical lab and a team of doctors in a form suitable for everyday use. Comprehensive lab-quality analysis can be performed by anyone, fundamentally shifting diagnostics from centralized facilities to the point-of-care and homes. The focus is to usher in Diagnostics 2.0, allowing high-value multiplexed diagnostics.Website: rhealth.comOther URL: startengine.com/offering/rhealthBiographical Information: Dr. Chan is a physician-inventor. He is currently Founder, CEO of rHEALTH, and President, CSO of DNA Medicine Institute, a medical innovation laboratory. He has been honored as Esquire magazine's Best and Brightest, one of MIT Technology Review's Top 100 Innovators, and an XPRIZE winner. His work has contributed to the birth of next-generation sequencing, health monitoring in remote environments, and therapeutics. Dr. Chan holds over 60 patents and publications, with work funded by the NIH, NASA, and USAF. Dr. Chan received an A.B. in Biochemical Sciences from Harvard College summa cum laude in 1996, received an M.D. from Harvard Medical School with honors in 2007, and trained in medicine at the Brigham and Women's Hospital. He has been in zero gravity and led the team that demonstrated the rHEALTH ONE bioanalyzer onboard the International Space Station.LinkedIn Profile: linkedin.com/in/eugene-chan-4220045Personal Twitter Handle: @Dr_EugeneChanSupport Our SponsorsOur generous sponsors make our work possible, serving impact investors, social entrepreneurs, community builders and diverse founders. Today's advertisers include Crowdfunding Made Simple. Learn more about advertising with us here.Max-Impact Members(We're grateful for every one of these community champions who make this work possible.)Brian Christie, Brainsy | Cameron Neil, Lend For Good | Carol Fineagan, Independent Consultant | Hiten Sonpal, RISE Robotics | John Berlet, CORE Tax Deeds, LLC. | Justin Starbird, The Aebli Group | Lory Moore, Lory Moore Law | Mark Grimes, Networked Enterprise Development | Matthew Mead, Hempitecture | Michael Pratt, Qnetic | Mike Green, Envirosult | Dr. Nicole Paulk, Siren Biotechnology | Paul Lovejoy, Stakeholder Enterprise | Pearl Wright, Global Changemaker | Scott Thorpe, Philanthropist | Sharon Samjitsingh, Health Care Originals | Add Your Name HereUpcoming SuperCrowd Event CalendarIf a location is not noted, the events below are virtual.SuperGreen Live, January 22–24, 2026, livestreaming globally. Organized by Green2Gold and The Super Crowd, Inc., this three-day event will spotlight the intersection of impact crowdfunding, sustainable innovation, and climate solutions. Featuring expert-led panels, interactive workshops, and live pitch sessions, SuperGreen Live brings together entrepreneurs, investors, policymakers, and activists to explore how capital and climate action can work hand in hand. With global livestreaming, VIP networking opportunities, and exclusive content, this event will empower participants to turn bold ideas into real impact. Don't miss your chance to join tens of thousands of changemakers at the largest virtual sustainability event of the year. Learn more about sponsoring the event here. Interested in speaking? Apply here. Support our work with a tax-deductible donation here.SuperCrowd Impact Member Networking Session: Impact (and, of course, Max-Impact) Members of the SuperCrowd are invited to a private networking session on January 27th at 1:30 PM ET/10:30 AM PT. Mark your calendar. We'll send private emails to Impact Members with registration details.Community Event CalendarSuccessful Funding with Karl Dakin, Tuesdays at 10:00 AM ET - Click on Events.Join C-AR Annual Reporting: Requirements, Deadlines, and Lessons Learned from the Field on January 14, 2026, an informative online webinar designed to help crowdfunding issuers and professionals clearly understand C-AR annual reporting requirements, key deadlines, and real-world insights to stay compliant and prepared.Join UGLY TALK: Women Tech Founders in San Francisco on January 29, 2026, an energizing in-person gathering of 100 women founders focused on funding strategies and discovering SuperCrowd as a powerful alternative for raising capital.If you would like to submit an event for us to share with the 10,000+ changemakers, investors and entrepreneurs who are members of the SuperCrowd, click here.Manage the volume of emails you receive from us by clicking here.We use AI to help us write compelling recaps of each episode. 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What is consciousness, really? Why does it not simply switch on at a single moment? Neuroscientist Niko Kukushkin explains how even single cells can show primitive forms of memory and agency, why the human mind is not a mysterious force floating above biology, and why reducing it to "just neurons" misses what actually matters. He also discusses the evolutionary gamble of complexity, why bacteria still dominate the planet, and how abstraction and memory together give rise to thought. At the center of the conversation is an unsettling question: Why does it feel so special to be you when science says that you are nothing but a chemical reaction—a collection of atoms and molecules, like rocks, paperclips, and everything else in the physical universe? Nikolay Kukushkin is a clinical associate professor at New York University and a research fellow at NYU's Center for Neural Science, where he studies how temporal patterns shape memory formation. He holds degrees from St. Petersburg State University and Oxford University, and completed postdoctoral training at Harvard Medical School. He is the author of a recent paper in Nature Communications demonstrating canonical memory in non-neural cells. His book is One Hand Clapping.

What if thousands of steps of gentle walking aren't giving you the brain protection you think they are? In this solo episode, I break down one of the most important exercise studies published in Nature Communications and what it means for your brain, longevity, and Alzheimer's risk. Tracking over 73,000 people for eight years using wearables, the findings are shocking: one minute of vigorous exercise is worth up to 10 minutes of moderate activity — not the outdated 2-to-1 rule. For diabetes prevention, it's nearly 10-to-1. For cardiovascular mortality, it's 8-to-1. And here's what no one is saying: every outcome measured — heart disease, diabetes, metabolic dysfunction — is an independent risk factor for Alzheimer's and dementia. I explain why vigorous exercise is so powerful for your brain: shear stress that strengthens blood vessels, lactate that triggers BDNF, muscle fiber recruitment that protects against falls and cognitive decline, and glucose regulation that defends against insulin resistance — a driver of neurodegeneration. Think vigorous exercise is out of reach? Good news: the study defines it as brisk stairs, carrying groceries, or playing actively with your kids. No gym required — just effort. Just 3–4 minutes of vigorous bursts per day can reduce all-cause mortality by 40% and cardiovascular events by nearly 50%. For women over 40, this is critical. Two-thirds of Alzheimer's cases are women, and perimenopause is a vulnerability window for the brain. Vigorous exercise can partially compensate for declining estrogen by improving glucose regulation, reducing inflammation, and protecting the brain in ways gentle movement cannot. *** Reduce your risk of Alzheimer's with my science-backed protocol for women 30+: https://go.neuroathletics.com.au/brain-code-yt Subscribe to The Neuro Experience for more conversations at the intersection of brain science and performance. I'm committed to bringing you evidence-based insights that you can apply to your own health journey. *** A huge thank you to my sponsors for supporting this episode. Check them out and enjoy exclusive discounts: Rho NutritionYou can get 20% off with the code NEURO at https://rhonutrition.com Function HealthVisit https://functionhealth.com/louisa or use gift code NEURO100 at sign-up to own your health. AquaTruGo to https://AquaTru.com now for 20% off using promo code NEURO. TimelineHead to https://www.timeline.com/neuro to get 20% off. Cure HydrationGet 20% off your first order at https://curehydration.com/neuro with code NEURO. *** I'm Louisa Nicola — clinical neurophysiologist — Alzheimer's prevention specialist — founder of Neuro Athletics. My mission is to translate cutting-edge neuroscience into actionable strategies for cognitive longevity, peak performance, and brain disease prevention. If you're committed to optimizing your brain — reducing Alzheimer's risk — and staying mentally sharp for life, you're in the right place. Stay sharp. Stay informed. Join thousands who subscribe to the Neuro Athletics Newsletter → https://bit.ly/3ewI5P0 Instagram: https://www.instagram.com/louisanicola_/ Twitter : https://twitter.com/louisanicola_ Topics discussed:00:00:00 Introduction: The Exercise Intensity Revolution 00:01:02 The Study That Changes Everything 00:04:50 The Flawed Foundation: Why Guidelines Were Wrong 00:06:50 The Real Numbers: 4 to 10 Times More Powerful 00:08:53 The Brain Connection No One Is Talking About 00:15:32 Mechanism 1: Shear Stress and Cerebral Blood Flow 00:17:38 Mechanism 2: Lactate and BDNF Production 00:19:25 Mechanism 3: Type 2 Muscle Fibers and Myokines 00:24:30 Mechanism 4: Glucose Regulation and Mitochondrial Health 00:28:18 VILPA: The 3-Minute Daily Game Changer 00:32:16 Women and Menopause: The Critical Window 00:35:19 Practical Protocols: What to Do Starting Today Learn more about your ad choices. Visit megaphone.fm/adchoices

Much of what we talk about on Better Brain Fitness resolves around the demand-driven decline model we published. Well...a new study just published in Nature Communications gave that model the best test to date, and the results are pretty darn exciting. So of course we had to do an episode about it! The study looks at the relationship between brain aging and creative activities like music, dance, art, and video gaming. Tommy walks through the study and explains why this matters for anyone thinking about their long-term cognitive health. What You'll Learn: A more sensitive way to measure brain aging than structural scans The connection between music, dance, art, and video gaming on brain aging The effect of 30 hours of video gaming on brain aging, the kinds of video games that have the greatest impact (and why traditional "brain games" haven't been as successful) What this research tells us about whether cognitive decline is reversible The dose-response relationship between complex activities and brain health   To submit a question for us to answer on the podcast, go to brainjo.academy/question. To subscribe to the free Better Brain Fitness newsletter, join us when we record live, and get our Guide and Checklist to essential blood tests and nutrients, go to: betterbrain.fitness. Click here to pre-order Dr. Wood's book, "The Stimulated Mind." Click here to grab Dr. Turknett's bestselling book, "Anyone Can Play Music" Intro and Outro music composed and produced by Julienne Ellen.   

In this episode, Jess and Sarah discuss the current state of bird flu, particularly H5N1, with expert Dr. Chad Costley. They explore the implications of recent CDC updates, the evolution of viruses, and the innovative development of intranasal vaccines. The conversation highlights the importance of addressing vaccine misinformation and the potential for a universal flu vaccine, emphasizing the need for continued public health efforts and the role of dedicated scientists in combating misinformation. Watch the conversation on YouTube: https://youtu.be/-Vlb14O_BeA (00:00) Intro & Public Health Update (03:07) What Is A News Item That Caught Your Attention And Why? (04:20) What Is Bird Flu? (07:11) How Could Bird Flu Become A Worst Case Scenario? (10:02) Exiting Research On A Possible Bird Flu Vaccine (13:38) Technology Behind The New Vaccine Candidate (17:43) Importance of Adjuvants (20:48) Where Does The New H5 Vaccine Stand In Development? (24:21) The Idea Of A Universal Flu Vaccine (29:25) What Is Giving Hope In Public Health? https://www.nature.com/articles/s41467-025-64686-3 https://www.globenewswire.com/news-release/2025/11/06/3182263/0/en/BlueWillow-Biologics-Intranasal-Bird-Flu-Vaccine-Shows-Signs-of-Broad-Immune-Response-in-Phase-I-Clinical-Trial-Published-in-Nature-Communications.html https://www.linkedin.com/in/chad-costley-a631a8164/ https://www.cidrap.umn.edu/avian-influenza-bird-flu/preliminary-human-bird-flu-case-reported-washington-state ----------------------------------------------------------------------------------------------------------------------- Interested in advertising with us? Please reach out to advertising@airwavemedia.com, with “Unbiased Science” in the subject line. PLEASE NOTE: The discussion and information provided in this podcast are for general educational, scientific, and informational purposes only and are not intended as, and should not be treated as, medical or other professional advice for any particular individual or individuals. Every person and medical issue is different, and diagnosis and treatment requires consideration of specific facts often unique to the individual. As such, the information contained in this podcast should not be used as a substitute for consultation with and/or treatment by a doctor or other medical professional. If you are experiencing any medical issue or have any medical concern, you should consult with a doctor or other medical professional. Further, due to the inherent limitations of a podcast such as this as well as ongoing scientific developments, we do not guarantee the completeness or accuracy of the information or analysis provided in this podcast, although, of course we always endeavor to provide comprehensive information and analysis. In no event may Unbiased Science or any of the participants in this podcast be held liable to the listener or anyone else for any decision allegedly made or action allegedly taken or not taken allegedly in reliance on the discussion or information in this podcast or for any damages allegedly resulting from such reliance. The information provided herein do not represent the views of our employers. Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode, Jess and Sarah discuss the current state of bird flu, particularly H5N1, with expert Dr. Chad Costley. They explore the implications of recent CDC updates, the evolution of viruses, and the innovative development of intranasal vaccines. The conversation highlights the importance of addressing vaccine misinformation and the potential for a universal flu vaccine, emphasizing the need for continued public health efforts and the role of dedicated scientists in combating misinformation. Watch the conversation on YouTube: https://youtu.be/-Vlb14O_BeA (00:00) Intro & Public Health Update (03:07) What Is A News Item That Caught Your Attention And Why? (04:20) What Is Bird Flu? (07:11) How Could Bird Flu Become A Worst Case Scenario? (10:02) Exiting Research On A Possible Bird Flu Vaccine (13:38) Technology Behind The New Vaccine Candidate (17:43) Importance of Adjuvants (20:48) Where Does The New H5 Vaccine Stand In Development? (24:21) The Idea Of A Universal Flu Vaccine (29:25) What Is Giving Hope In Public Health? https://www.nature.com/articles/s41467-025-64686-3 https://www.globenewswire.com/news-release/2025/11/06/3182263/0/en/BlueWillow-Biologics-Intranasal-Bird-Flu-Vaccine-Shows-Signs-of-Broad-Immune-Response-in-Phase-I-Clinical-Trial-Published-in-Nature-Communications.html https://www.linkedin.com/in/chad-costley-a631a8164/ https://www.cidrap.umn.edu/avian-influenza-bird-flu/preliminary-human-bird-flu-case-reported-washington-state ----------------------------------------------------------------------------------------------------------------------- Interested in advertising with us? Please reach out to advertising@airwavemedia.com, with “Unbiased Science” in the subject line. PLEASE NOTE: The discussion and information provided in this podcast are for general educational, scientific, and informational purposes only and are not intended as, and should not be treated as, medical or other professional advice for any particular individual or individuals. Every person and medical issue is different, and diagnosis and treatment requires consideration of specific facts often unique to the individual. As such, the information contained in this podcast should not be used as a substitute for consultation with and/or treatment by a doctor or other medical professional. If you are experiencing any medical issue or have any medical concern, you should consult with a doctor or other medical professional. Further, due to the inherent limitations of a podcast such as this as well as ongoing scientific developments, we do not guarantee the completeness or accuracy of the information or analysis provided in this podcast, although, of course we always endeavor to provide comprehensive information and analysis. In no event may Unbiased Science or any of the participants in this podcast be held liable to the listener or anyone else for any decision allegedly made or action allegedly taken or not taken allegedly in reliance on the discussion or information in this podcast or for any damages allegedly resulting from such reliance. The information provided herein do not represent the views of our employers. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

This special episode brings together the moments from 2025 that listeners told us had the biggest impact on how they eat, think, and feel. It's been a year full of surprising insights, practical shifts, and ideas that made healthy eating feel a little more doable. From gut health breakthroughs to simple food habits that spark real change, these clips highlight the advice that resonated most - that people returned to, shared, and said genuinely helped them feel better. Whether you're pausing to take stock of the year or simply looking for small ideas to weave into everyday life, this episode offers some science-backed inspiration you can carry forward in your own way. Unwrap the truth about your food

Get access to more than 200 episodes of my premium podcast (The Aliquot) when you sign up as a FoundMyFitness Premium Member Download my "How to Train According to the Experts" guide One minute of vigorous exercise may be worth up to ten minutes of "moderate" cardio for extending lifespan and preventing chronic disease. In this Journal Club episode, Rhonda Patrick, PhD and endurance athlete Brady Holmer dissect a new Nature Communications study of more than 70,000 adults showing that vigorous intensity is roughly 4–10x more potent than moderate activity for reducing all-cause mortality, cardiovascular events, type 2 diabetes, and cancer outcomes—far beyond the long-standing 1:2 rule embedded in global exercise guidelines. Timestamps: (00:00) Introduction (07:01) What exactly is the 1:2 rule for exercise intensity? (08:18) Calorie burn vs. longevity—origins of the 1:2 rule (11:15) What counts as 'vigorous' exercise, really? (13:35) Where the exercise guidelines fall short (14:19) Can your wearable predict disease risk years in advance? (20:11) Is vigorous activity easier to achieve than people think? (22:47) How researchers avoided the 'healthy user bias' (23:59) Health equivalence ratio—a better way to measure exercise benefits? (25:45) Is vigorous exercise truly 4–10x more effective? (29:55) Can one vigorous minute match an hour of gentle walking? (32:02) Why vigorous activity—not gentle—offers dose-dependent benefits (33:50) Is vigorous exercise 5x better at preventing heart attacks & strokes? (34:24) Why vigorous activity stands out for cancer prevention (34:59) Does zone 2 qualify as vigorous exercise? (36:11) Dose-response comparison—vigorous vs. moderate vs. light activity (37:22) Is vigorous exercise the secret to younger arteries? (43:15) Why aging hearts need intensity (46:09) Can vigorous exercise halt your VO₂ max decline? (47:26) Why moderate exercise alone might not improve VO₂ max (49:21) Is vigorous exercise 10x more powerful at preventing diabetes? (55:48) Mitochondrial biogenesis—why intensity is essential (58:40) Can you directly measure mitochondrial health? (1:00:57) Does vigorous exercise kill circulating tumor cells? (1:07:15) Why vigorous intensity triggers beneficial hormone changes (1:08:05) Can vigorous activity protect older adults from falls? (1:12:36) Does vigorous exercise combat inflammation? (1:14:29) Is high-intensity training the key to a younger brain? (1:16:01) Is vigorous exercise more powerful than we realized? (1:17:50) Can the benefits of vigorous exercise fit into a pill? (1:19:08) How small doses of intensity might extend your lifespan (1:23:15) Do short bursts of vigorous movement match full workouts? (1:27:26) Why your wearable might undervalue short vigorous bouts (1:30:06) Can planned micro-workouts replace traditional gym sessions? (1:35:10) Why exercise guidelines urgently need updating (1:46:35) Does light activity still offer real benefits? (1:49:04) Is vigorous exercise safe for older adults? (1:53:28) Are high-intensity workouts detrimental to female hormones? (1:58:02) Safe vigorous exercise options—even with chronic illness (1:59:05) The 80/20 rule for balancing intensity and recovery (2:01:30) Inside Brady's routine—how much vigorous exercise is optimal? (2:05:17) Can vigorous activity boost kids' brainpower (and grades)? (2:08:14) Are we significantly underestimating vigorous exercise benefits? (2:10:03) Why chasing steps isn't the answer Show notes are available by clicking here Watch this episode on YouTube