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5 episodes with dna methylation
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2 episodes with dna methylation
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In this episode, we dive deep into the world of longevity science and epigenetic testing with TruDiagnostic . We discuss the accuracy of biological age tests, the ethical and regulatory challenges in the industry, and how personalized interventions could reshape the future of health. Whether you're skeptical or curious, this conversation uncovers what's real, what's hype, and what the future holds for longevity research. https://youtu.be/UzTjW9oDTlE https://youtu.be/UzTjW9oDTlELearning with Lowell links Spotify: https://open.spotify.com/show/66eFLHQclKe5p3bMXsCTRH RSS: https://www.learningwithlowell.com/feed/podcast/ Youtube: https://www.youtube.com/channel/UCzri06unR-lMXbl6sqWP_-Q Website: https://www.learningwithlowell.com Dr. Matthew Dawson and TruDiagnostic links: https://trudiagnostic.com https://www.linkedin.com/in/matthew-dawson-75196040 About TruDiagnostic “TruDiagnostic is a state of the art epigenetic testing company, specializing in Biological Aging, Nutritional Deficiencies, and Cellular Systems Health based on DNA Methylation. We offer testing for clinical practitioners and their patients, and consumers. TruDiagnostic is dedicated to utilizing validated research and rigorous scientific standards to expand our knowledge and analysis into Epigenetics and Aging. We also participate in research studies, using our validated Biological Age test (TruAge) to verify claims from interventional products. Our goal for the future is to continue to develop our DNA Methylation analytical ability until we can successfully identify markers that can be used by physicians to diagnose age-related diseases before they show outward symptoms, and let them begin early interventions. “ Timestamps: 00:00 - Introduction to longevity, health, and lifespan. 00:05 - Guest introduction: Matt's company was featured on the Kardashians. 00:11 - The Kardashians used Matt's product and featured it on their show. 00:29 - How the Kardashians initially used the product anonymously. 00:47 - The business impact of being featured on their show. 2:24 - Concerns about a deep science company being associated with pop culture. 3:39 - The role of influencers in translating deep tech for the general public. 4:53 - Questions from new customers after the Kardashian episode. 5:38 - Differentiating from inaccurate biological age tests. 6:08 - Issues with market confusion and low-quality alternatives. 7:03 - Strategies to rise above market noise (publications, collaborations). 8:07 - Explanation of True Diagnostic's work. 9:02 - Why early biological age tests were not useful. 9:40 - The breakthrough with Duke's "Pace of Aging" test. 10:30 - Sensitivity of the test to interventions (pregnancy, stress, COVID). 11:43 - Clinical use cases: testing interventions in real-time. 12:01 - Accuracy of the new tests versus old biological age models. 13:00 - Practical applications of knowing your aging rate. 14:01 - The relationship between aging and disease risk. 15:02 - Why aging is the biggest health risk factor. 15:20 - Rising chronic diseases and lifestyle factors. 16:49 - Microplastics, environmental toxins, and their potential impact. 17:57 - Exercise and cognitive health. 18:59 - The importance of heart health for brain function. 19:54 - Types of exercise and their impact on aging. 22:14 - How AI can optimize personal health recommendations. 23:48 - AI-assisted food recommendations based on genetics. 25:17 - The future of AI-driven precision medicine. 26:49 - How precision medicine can add 20 years to lifespan. 28:16 - The role of genetic and biomarker testing in personalized medicine. 32:00 - The potential for AI-driven medical interventions. 36:07 - Collaborations with top universities (Harvard, Duke, Mayo Clinic). 38:56 - Using AI for predictive health insights. 42:26 - The possibility of a single blood test diagn...
Physician Ash Alizadeh has seen the future of disease diagnosis and monitoring. It is coursing through every patient's veins. Traditionally, biopsies have required invasively gathering tissue – from a lung, a liver, or a fetus. Now it's possible to look for disease without surgery. The DNA is sitting there in the bloodstream, Alizadeh tells host Russ Altman, as they preview the age of liquid biopsies on this episode of Stanford Engineering's The Future of Everything podcast.Have a question for Russ? Send it our way in writing or via voice memo, and it might be featured on an upcoming episode. Please introduce yourself, let us know where you're listening from, and share your quest. You can send questions to thefutureofeverything@stanford.edu.Episode Reference Links:Stanford Profile: Ash A. Alizadeh, MD/PhDConnect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>> Twitter/X / Instagram / LinkedIn / FacebookChapters:(00:00:00) IntroductionRuss Altman introduces guest Ash Alizadeh, a faculty member at Stanford University in Oncology and Medicine.(00:03:39) What is a Liquid Biopsy?Accessing tissues non-invasively using bodily fluids.(00:04:31) Detecting Cancer with Liquid BiopsiesHow localized cancers can be detected through blood samples.(00:06:32) The Science Behind Cancer DNA DetectionThe differences between normal and cancer DNA(00:09:51) How Liquid Biopsy Technology WorksThe technologies behind detecting cancer-related DNA differences.(00:12:36) Advances in Liquid BiopsyNew detection approaches using non-mutant molecules and RNA.(00:14:10) RNA as a Real-Time Tumor MarkerHow RNA reveals active tumor processes and drug resistance.(00:15:55) Tracking Cancer ReccurenceUsing tumor-informed panels to monitor cancer recurrence.(00:16:28) Adapting to Tumor EvolutionWhy core mutations remain detectable despite cancer changes.(00:17:57) Stability of DNA, RNA, and MethylationComparing durability and reliability of different biomarkers.(00:20:49) Listener Question: Early Cancer DetectionDaniel Kim asks about pre-cancer detection and its potential impact.(00:24:44) Liquid Biopsy in ImmunotherapyUsing liquid biopsy to track and improve immune-based treatments.(00:27:35) Monitoring CAR T-Cell TherapyHow liquid biopsy helps assess immune cell expansion.(00:32:02) EPIC-Seq: Inferring RNA from DNAUsing DNA fragmentation to predict gene expression in tumors.(00:34:49) Targeting Tumor Support SystemsTreatment strategies disrupting the tumor microenvironment.(00:35:52) Conclusion Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook
BUFFALO, NY—February 12, 2025 — A new #research paper was #published in Aging (Aging-US) on January 3, 2025, in Volume 17, Issue 1, titled “Characterization of DNA methylation clock algorithms applied to diverse tissue types.” Researchers Mark Richardson, Courtney Brandt, Niyati Jain, James L. Li, Kathryn Demanelis, Farzana Jasmine, Muhammad G. Kibriya, Lin Tong, and Brandon L. Pierce from the University of Chicago and University of Pittsburgh, studied how biological aging is measured using DNA. Their study found that while commonly used “DNA methylation clocks” work well for blood samples, they may be less reliable for other tissues like the lungs, colon, and kidneys. DNA methylation clocks are widely used in forensic science, epigenetics and longevity research to estimate a person's biological age based on chemical changes in DNA. These epigenetic clocks help scientists predict age-related diseases and assess how lifestyle factors, such as smoking, impact aging. Most were originally developed using blood samples, and their effectiveness in other tissues remains unclear. This study tested eight different DNA methylation clocks across nine human tissue types, including the lungs, prostate, ovaries, skeletal muscle, and kidneys. The researchers analyzed data from 973 tissue samples collected through the Genotype-Tissue Expression (GTEx) project. Their analysis revealed significant differences in biological age estimates across tissues. While blood samples provided the most reliable results, other tissues showed noticeable variations. For example, testis and ovary tissues appeared younger than expected, while lung and colon tissues appeared older. “These differences across tissue types were most apparent for clocks trained using DNAm from blood only (e.g., Hannum), but also present for clocks trained on multiple tissue types (e.g., Horvath, a clock designed for pan-tissue age prediction.” These findings suggest that aging may not occur at the same rate in every organ, and that standard DNA methylation clocks may not always give accurate biological age estimates outside of blood samples. The authors suggest that new, organ-specific epigenetic clocks may be needed to improve biological age prediction. Creating tissue-specific aging clocks could also improve medical diagnostics, age-related disease prevention, and health monitoring. The researchers emphasize that larger studies with more tissue-specific DNA methylation data are needed to refine these aging clocks. By improving these tools, scientists can better understand how aging affects different organs and develop more reliable methods for measuring biological age. These advancements could lead to better predictions of age-related diseases and new strategies for healthy aging. DOI - https://doi.org/10.18632/aging.206182 Corresponding author - Brandon L. Pierce - brandonpierce@uchicago.edu Video short - https://www.youtube.com/watch?v=Jz-daRsZO2o Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts About Aging-US The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population. The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.) Please visit our website at https://www.Aging-US.com and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM
The publication of this content was funded by Beiersdorf.* Tune into this Article Recap Join leading dermatologists and epigenetics researchers Frank Lyko, Firas Al-Niaimi, Hassan Galadari, Elke Grönniger, and Julia Gallinger in this insightful audio recap of an article exploring groundbreaking approaches to facial skin ageing. Highlights from a European Academy of Dermatology & Venereology (EADV) symposium shed light on the latest advancements in epigenetics in combination with innovative skincare interventions. The discussion covers: mechanisms of reversible DNA methylation changes in skin ageing and their potential for transformative treatments; the skin-specific age clock, an AI-powered tool which measures biological skin age and supports the creation of Epicelline®, an active ingredient targeting DNA methylation to reverse clinical signs of ageing; outcomes in laser therapies with additional use of Epicelline®; and case studies on combining Epicelline® with aesthetic treatments such as chemical peels, microneedling, and injectables. *The following recording is an audio article sponsored and provided by Beiersdorf, and hosted on the EMJ Podcast: Insights for Healthcare Professionals. It is aimed at healthcare professionals and recaps the symposium review article entitled, ‘Reverse the Age Clock: Reverse Clinical Signs of Ageing with Epigenetic Skin Science', published in EMJ Dermatology 12.1 in November 2024. To access the full article, visit emjreviews.com. The content included is promotional and contains product placement, highlighting specific products or services, including paid partnerships or sponsorships. Please consult reliable resources or professional advice for any questions about the topics discussed. The opinions expressed do not necessarily represent the opinions of EMJ.
BUFFALO, NY- January 20, 2025 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) on December 5, 2024, Volume 16, Issue 22, titled “DNA-methylation age and accelerated epigenetic aging in blood as a tumor marker for predicting breast cancer susceptibility.” Researchers Su Yon Jung, Herbert Yu, Youping Deng, and Matteo Pellegrini from the University of California, Los Angeles and University of Hawaii Cancer Center have found that a simple blood test could help predict breast cancer (BC) risk in older women. Their study focuses on epigenetic aging, a process that reflects how fast the body's cells age based on DNA methylation changes (DNAm). Breast cancer is one of the most common cancers worldwide, with the risk increasing significantly after menopause. The researchers analyzed blood samples from postmenopausal, non-Hispanic white women. They discovered that those with an “older” biological age had a significantly higher risk of being diagnosed with breast cancer. The risk was even greater in women who had their ovaries removed before natural menopause, likely due to reduced estrogen levels, a hormone that plays a key role in aging and breast health. “Of note, in women with bilateral oophorectomy before natural menopause experiencing shorter lifetime estrogen exposure than those with natural menopause, epigenetic age accel substantially influenced BC development, independent of obesity status and exogeneous estrogen use.” The study also found that lifestyle factors influence epigenetic aging and breast cancer risk. Women with obesity experienced faster biological aging, which increased their risk of developing cancer. Meanwhile, hormone replacement therapy had varying effects depending on the type and duration of treatment. Early detection of breast cancer is crucial for effective treatment and survival. Traditional risk assessments—such as age, family history, and lifestyle habits—may not provide the full picture. This study suggests that adding a blood test to measure biological aging could help clinicians identify high-risk women earlier and offer personalized prevention strategies. With further research, this blood test could become a routine screening tool in women's health check-ups. It may empower women to take proactive steps to reduce their breast cancer risk through healthy lifestyle choices, including maintaining a balanced diet, staying physically active, and considering appropriate hormone therapies under medical supervision. In conclusion, further studies are needed to validate these findings and explore their applicability to a broader population of women. However, this research presents a promising, non-invasive, and cost-effective approach to predicting breast cancer risk. DOI - https://doi.org/10.18632/aging.206169 Corresponding author - Su Yon Jung - sjung@sonnet.ucla.edu Video short - https://www.youtube.com/watch?v=g1tHojirvI8 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts About Aging-US The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population. The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.) Please visit our website at https://www.Aging-US.com and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM
In this episode of the Epigenetics Podcast, we talked with Maxim Greenberg from the Institute Jacob Monot about his work on epigenetic consequences of DNA methylation in development. In this interview we explore how Dr. Greenbergs work at UCLA involved pioneering experiments on DNA methylation mechanisms and how this period was marked by significant collaborative efforts within a highly competitive yet supportive lab environment that ultimately lead to publications in high impact journals. His transition to a postdoctoral position at the Institut Curie with Deborah Bourc'his harnessed his newfound expertise in mammalian systems, examining chromatin changes and the implications for embryonic development. Dr. Greenberg explained the nuances of his research, particularly how chromatin modifications during early development can influence gene regulatory mechanisms later in life, providing a compelling narrative about the potential long-term impacts of epigenetic changes that occur in utero. Throughout our conversation, we examined the intricate relationship between DNA methylation and Polycomb repression, discussing how these epigenetic mechanisms interact and the functional outcomes of their regulation. Dr. Greenberg's insights into his recent studies reveal a commitment to unraveling the complexities of enhancer-promoter interactions in the context of epigenetic regulation. References Greenberg, M. V., Ausin, I., Chan, S. W., Cokus, S. J., Cuperus, J. T., Feng, S., Law, J. A., Chu, C., Pellegrini, M., Carrington, J. C., & Jacobsen, S. E. (2011). Identification of genes required for de novo DNA methylation in Arabidopsis. Epigenetics, 6(3), 344–354. https://doi.org/10.4161/epi.6.3.14242 Greenberg, M. V., Glaser, J., Borsos, M., Marjou, F. E., Walter, M., Teissandier, A., & Bourc'his, D. (2017). Transient transcription in the early embryo sets an epigenetic state that programs postnatal growth. Nature genetics, 49(1), 110–118. https://doi.org/10.1038/ng.3718 Greenberg, M., Teissandier, A., Walter, M., Noordermeer, D., & Bourc'his, D. (2019). Dynamic enhancer partitioning instructs activation of a growth-related gene during exit from naïve pluripotency. eLife, 8, e44057. https://doi.org/10.7554/eLife.44057 Monteagudo-Sánchez, A., Richard Albert, J., Scarpa, M., Noordermeer, D., & Greenberg, M. V. C. (2024). The impact of the embryonic DNA methylation program on CTCF-mediated genome regulation. Nucleic acids research, 52(18), 10934–10950. https://doi.org/10.1093/nar/gkae724 Richard Albert, J., Urli, T., Monteagudo-Sánchez, A., Le Breton, A., Sultanova, A., David, A., Scarpa, M., Schulz, M., & Greenberg, M. V. C. (2024). DNA methylation shapes the Polycomb landscape during the exit from naive pluripotency. Nature structural & molecular biology, 10.1038/s41594-024-01405-4. Advance online publication. https://doi.org/10.1038/s41594-024-01405-4 Related Episodes DNA Methylation and Mammalian Development (Déborah Bourc'his) Circulating Epigenetic Biomarkers in Cancer (Charlotte Proudhon) Epigenetic Mechanisms in Genome Regulation and Developmental Programming (James Hackett) Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com
In this episode of the Gladden Longevity Podcast, Dr. Jeffrey Gladden interviews Hannah Went, co-founder of TrueAge, a leading omics age company. They discuss the significance of epigenetics in understanding biological age, the predictive power of various aging clocks, and the advancements in measuring biological age through multi-omics approaches. The conversation also covers the impact of interventions like caloric restriction on aging metrics, the Dunedin Pace as a new metric for biological aging, and the complexity of aging as a multifactorial process. Went shares insights into the future of epigenetic research and the importance of actionable insights for health optimization. For the audience: * Use the code 'Podcast10' to get 10% OFF your order at our supplement store → https://gladdenlongevityshop.com/ Takeaways * Epigenetic markers can predict chronological age with high accuracy. * GrimAge is a new clock that estimates mortality risk. * Multi-omics approaches provide a comprehensive view of aging. * Caloric restriction significantly impacts biological age. * Dunedin Pace measures the rate of biological aging. * Aging is a complex, multifactorial process. * Understanding what tests do not measure is crucial. * New biomarkers for aging are being developed and validated. Chapters 00:00 Introduction to Omics Age and TrueAge 04:12 The Evolution of Epigenetic Clocks 07:55 Integrating Lifestyle Factors in Omics Age Testing 10:14 Predicting Disease Risk and Mortality with Omics Age 13:27 Reversing Biological Age with Interventions 16:42 Actionable Insights from Omics Age Testing 26:30 Exploring the Impact of Caloric Restriction on Aging 29:08 Understanding the Dunedin Pace as a Measure of Biological Aging 33:32 The Complexity of Aging and the Limitations of Single Metrics 35:24 Epigenetic Biomarker Proxies: A Comprehensive Approach to Aging 43:59 Cell Reprogramming and its Implications for Aging 49:24 Goodbye Learn more about TruAge and/or contact them: Email: hannah@trudiagnostic.com Website: https://www.trudiagnostic.com/ Facebook: https://www.facebook.com/TruDiagnostic/ Instagram: https://www.instagram.com/trudiagnosticofficial/ X: https://x.com/TruDiagnostic YouTube: https://www.youtube.com/c/trudiagnostic TikTok: https://www.tiktok.com/@trudiagnostic?is_from_webapp=1&sender_device=pc LinkedIn: https://www.linkedin.com/company/trudiagnostic/ Reach out to us! Website: https://gladdenlongevity.com/ Email: podcast@gladdenlongevity.com Facebook: https://www.facebook.com/Gladdenlongevity/ Instagram: https://www.instagram.com/gladdenlongevity/?hl=en LinkedIn: https://www.linkedin.com/company/gladdenlongevity YouTube: https://www.youtube.com/channel/UC5_q8nexY4K5ilgFnKm7naw
Dr. Evan Noch interviews Drs. Nathan Leclair, David Raleigh and Olga Anczukow about their recent manuscript entitled: "RNA splicing as a biomarker and phenotypic driver of meningioma DNA methylation groups", published online in Neuro-Oncology in August 2024.
In this episode, Dr. Jess Steier and Dr. Sarah Scheinman explore the fascinating field of epigenetics, which examines how external factors influence gene expression and impact health outcomes. They discuss the interplay between nature and nurture, explaining how epigenetics involves information layered on top of DNA that affects gene operation. The scientists cover key mechanisms like DNA methylation and histone modifications, and how factors such as nutrition and stress can impact these processes. They highlight landmark studies, including research on agouti mice and the Dutch Famine Birth Cohort Study, which demonstrate the long-term effects of environmental factors on gene expression and disease risk. The conversation also touches on the implications of epigenetics for mental health and the potential for future advancements in personalized medicine. Throughout the episode, Dr. Steier and Dr. Scheinman emphasize the complex relationship between genetics and environment in shaping human development and health. All our sources from this episode are available at: https://www.unbiasedscipod.com/episodes/ (00:00) Introduction (02:27) Understanding Genetics and the Human Genome (06:23) Epigenetics: Layered Information on Top of DNA (10:19) Explaining Methylation and Histones (16:20) External and Internal Regulation of Epigenetic Modifications (18:43) Transgenerational Epigenetic Inheritance (21:21) Landmark Studies in Epigenetics: Agouti Mice (23:35) Environmental Influence on Epigenetic Markers in Twins (26:07) Prenatal Exposure to Famine and DNA Methylation (28:36) The Effects of Space Travel on Epigenetic Markers (30:52) Epigenetics and Mental Health (36:25) Final Thoughts: Future Advancements in Manipulating Epigenetic Changes Interested in advertising with us? Please reach out to advertising@airwavemedia.com, with “Unbiased Science” in the subject line. PLEASE NOTE: The discussion and information provided in this podcast are for general educational, scientific, and informational purposes only and are not intended as, and should not be treated as, medical or other professional advice for any particular individual or individuals. Every person and medical issue is different, and diagnosis and treatment requires consideration of specific facts often unique to the individual. As such, the information contained in this podcast should not be used as a substitute for consultation with and/or treatment by a doctor or other medical professional. If you are experiencing any medical issue or have any medical concern, you should consult with a doctor or other medical professional. Further, due to the inherent limitations of a podcast such as this as well as ongoing scientific developments, we do not guarantee the completeness or accuracy of the information or analysis provided in this podcast, although, of course we always endeavor to provide comprehensive information and analysis. In no event may Unbiased Science or any of the participants in this podcast be held liable to the listener or anyone else for any decision allegedly made or action allegedly taken or not taken allegedly in reliance on the discussion or information in this podcast or for any damages allegedly resulting from such reliance. The information provided herein do not represent the views of our employers. Learn more about your ad choices. Visit megaphone.fm/adchoices
Welcome back to the Health Upgrade Podcast! In this episode, we sit down with Ryan Smith, the founder of TruDiagnostic, to talk about the fascinating world of DNA methylation and its role in personalized healthcare and aging. Founded in 2020, True Diagnostic uses AI and genomics to build the largest private epigenetic database.Ryan breaks down epigenetics by comparing DNA to hardware and gene expression to software. He explains how changing the way DNA works without altering its sequence can have a big impact on health and aging.We also learn about Ryan's journey from medical school to starting a pharmacy focused on peptides, and eventually founding TruDiagnostic. The episode dives into DNA methylation clocks, predictive technology for aging, and the potential of cellular reprogramming. There's also discussion on using epigenetic treatments for animals, anti-aging strategies for dogs, and how things like diet, climate change, and lifestyle affect our genes.Tune in to discover how cutting-edge science is shaping the future of healthcare. Whether you're looking to optimize your health or just curious about the future of medicine, this episode is full of valuable insights and practical tips!Dr. Navaz HabibEmail: podcast@healthupgraded.comFacebook: https://www.facebook.com/DrNavazHabib/Instagram: https://www.instagram.com/drnavazhabib/LinkedIn: https://ca.linkedin.com/in/drnavazhabibJP ErricoLinkedIn: https://www.linkedin.com/in/jp-errico-097629aaRyan Smith LinkedIn: https://www.linkedin.com/in/ryan-smith-lexington-ky/Website: https://www.trudiagnostic.com/
In this episode of The Shift with CJ, CJ explores the fascinating world of epigenetics and its profound impact on health, longevity, and overall well-being. Epigenetics, the study of how behavior and environment can alter gene expression without changing the DNA sequence, is described as the "director" of our genetic "script." CJ breaks down complex scientific concepts like DNA methylation, histone modifications, and non-coding RNAs, explaining how they influence aging and disease. The episode also delves into practical lifestyle changes and biohacks that can positively impact epigenetic regulation, promoting a longer and healthier life.Key Takeaways:Understanding Epigenetics: Your DNA acts as the script of your life, but epigenetics, influenced by your environment and behavior, determines how that script plays out. It's like a light switch that can turn certain genes on or off, impacting your health and longevity.DNA Methylation and Histone Modifications: These are crucial processes that influence gene expression. While DNA methylation can silence or activate genes, histone modifications help in the packaging of DNA, which affects how genes are expressed. Both are heavily influenced by lifestyle factors.Impact of Non-Coding RNAs: These molecules, although not translated into proteins, play a significant role in regulating gene expression, impacting everything from aging to disease susceptibility.Lifestyle is Key: Supplements and biohacks are helpful, but the foundation of good health starts with a healthy lifestyle. This includes a nutrient-rich diet, proper sleep, regular exercise, and stress management.Practical Biohacks: From consuming polyphenol-rich foods like berries and green tea to using cutting-edge techniques like pulsed electromagnetic field therapy (PEMF) and infrared saunas, CJ discusses various methods to enhance your epigenetic health.5 Actionable Steps to Improve Your Life:Incorporate Folate into Your Diet: Folate-rich foods like leafy greens and legumes support DNA methylation, which is crucial for healthy gene expression.Consume Polyphenol-Rich Foods: Berries, green tea, dark chocolate, and red wine contain polyphenols that positively influence epigenetics. Moderation is key, especially with red wine.Add Cruciferous Vegetables: Broccoli, cauliflower, and other cruciferous vegetables contain sulforaphane, which helps modulate histone deacetylase activity, promoting healthy aging.Explore Infrared Saunas: Regular use of infrared saunas can support longevity by promoting positive gene expression changes and detoxification.Consider PEMF Therapy: This advanced biohack uses electromagnetic fields to improve cellular health and influence gene expression, offering benefits similar to grounding but with enhanced effects.This episode emphasizes the importance of understanding and influencing your epigenetics to achieve optimal health. By making small, consistent lifestyle changes and exploring biohacking techniques, you can take control of your biology and live a longer, healthier life.
Dr Bernadette Jones-Freeman, PhD, Monash University, on the epigenetics of ageing and exercise, particularly in skeletal muscle, plus DNA Methylation. Dr Paris Papagianis from Respiratory Pharmacology Lab, Monash University on silicosis early life exposure and lung health, and the disease spanning early life to adulthood. Plus, Dr Rachel Kirby, School of Earth, Atmosphere and Environment at Monash University, on how impacts can concentrate metal at the surface of asteroids, the role that asteroids impacts have in controlling the chemistry of planets, which has implications for the composition of the Earth's core.Program page: Einstein-A-Go-GoFacebook page: Einstein-A-Go-GoTwitter: Einstein-A-Go-Gowith hosts: Dr Shane. Dr Ray, Dr Jen.
In today's episode, you'll dive deep into the world of cutting-edge diagnostics and personalized health management with Dr. Matthew Dawson, a seven-time guest. You might know Dr. Dawson for his groundbreaking work at Wild Health (use code BEN20 to save 20%), where he's revolutionizing patient care with advanced DNA methylation testing and AI-driven health recommendations. Use code BENVIP for 10% off the TruDiagnostics TruAge Pace Test. During this show, Dr. Dawson and I explore the intriguing evolution of methylation tests, demystify various biological age tests, and provide insights into how lifestyle choices significantly impact gene expression. Additionally, you'll discover the potential of AI in providing personalized health advice, the importance of human connection, proactive cancer detection strategies, and much more. Dr. Dawson attended medical school at the University of Kentucky before completing his residency in emergency medicine at The University of Utah, where he served as both chief resident and fellow. He has practiced medicine and was an associate professor at the University of Kentucky for seven years, with an acute interest in functional medicine and, later, genomics. Dr. Dawson crystallized this approach to providing patients with true health care, rather than sick care, by building Wild Health — a Precision Medicine service providing personalized, genetics-based care to help patients achieve optimal well-being. Dr. Dawson has trained thousands of physicians in Precision Medicine through online education and has lectured in over twenty countries around the world. He also co-hosts the Wild Health Podcast, a tool for teaching thousands about personalized, genetics-based Precision Medicine. His passion for helping patients maximize their health span and perform at their absolute best considers all aspects of health: mental, physical, and spiritual. For full show notes: https://bengreenfieldlife.com/drdawson Episode Sponsors: Beekeepers: Go to beekeepersnaturals.com/BEN or enter code BEN to get 20% off your order. Manukora: Go to manukora.com/ben or use code BEN, you'll automatically get a free pack of honey sticks with your order - a $15 value. Jigsaw Health: Visit JigsawAC.com and use "Greenfield10" to get 10% off on your order. LeelaQ: Visit http://leelaq.com/ben and use code BEN10 for 10% off. LVLUP Health: Head over to lvluphealth.com/BGL for a special discount on their game-changing range of products.See omnystudio.com/listener for privacy information.
Dr. Ari Calhoun is a perinatal and pediatric naturopathic doctor and mother of two. She is the owner and director of Wholesome Brain Medicine, focusing on optimizing neurodevelopment and emotional regulation from the womb onward. As an adjunct faculty of the Medical Academy of Pediatrics, she is a passionate speaker and advocate on the importance of a biomedical approach toward neurodevelopmental disorders. She is licensed by the California Board of Naturopathic Medicine, holds a Doctorate in Naturopathic Medicine from Bastyr University in San Diego, California, and graduated Summa Cum Laude with a Bachelor of Science in Exercise Science and a Minor in Clinical Nutrition Sciences from Syracuse University in Syracuse, New York. Together Dr. Ari and I dive into the many ways that practitioners can take a proactive stance on prenatal and neurodevelopmental care to support the high-risk profiles of their patients. She shares tactics for mitigating risk and supporting proactive prenatal and neurodevelopmental care through nutrients. She highlights research behind anti-brain antibodies in pregnant moms, details folate receptor antibodies, offers lab recommendations, and explores the need for dairy in most diets. Ari also covers the risks associated with maternal infections, the supplements and lab tests that she recommends for her patients, and the danger of a zinc-copper imbalance. Ari has a wealth of information on these lesser-known topics, and our conversation is filled with a variety of clinical pearls that practitioners can use to help support parents as they navigate prenatal and postpartum care as well as for children with autism. I'm your host, Evelyne Lambrecht, thank you for designing a well world with us. Episode Resources: Dr. Ari Calhoun Wholesome Brain Medicine Designs for Health - https://www.designsforhealth.com/ Nutrition Blog: Choline – A Critical Nutrient During Pregnancy - https://www.casi.org/node/1080 Research Blog: Do Higher Prenatal Choline Levels Mitigate Fetal Impact of Respiratory Infections - https://www.casi.org/node/1274 Research Blog: Autism and Cerebral Folate Deficiency - https://www.casi.org/bid/166694/Autism-and-Cerebral-Folate-Deficiency Research Blog: Functional roles of Zinc - https://www.casi.org/node/1193 Science Update: Recent Study Explores Impact of Folate Supplementation During Pregnancy on Newborn's DNA Methylation and Neural Outcomes - https://www.casi.org/node/1596 Science Update: New Study Investigates the Effect of Vitamin D Status during Pregnancy on Infant Neurodevelopment - https://www.casi.org/node/1312 Visit the Designs for Health Research and Education Library which houses medical journals, protocols, webinars, and our blog. https://www.designsforhealth.com/research-and-education/education Chapters: 00:00 Intro 02:05 Ari recalls the experiences that fueled her passion for brain health, fertility, and working with children. 04:45 Holistically optimizing neurodevelopment starts with a focused approach to maternal prenatal health. 08:04 The impact of maternal immune activation and inflammation on neurodevelopment. 13:02 Common maternal infections that tend to trigger immune activation, include stress and metabolic conditions. 16:41 Ari highlights safe prenatal nutrients that have been sufficiently studied and optimize prenatal care. 21:39 Details and dosing for zinc, copper, folate, Vitamin C, and other beneficial supplements. 27:00 Research regarding the safety and concerns of melatonin use in pregnancy. 28:49 Ari weighs in on glutathione controversy and Tylenol usage in pregnancy. 32:07 The phenomenon of anti-brain antibodies and their association to severe forms of autism, and key risk factors for mom and baby. 36:51 Determining the appropriate timing for anti-brain antibody testing to proactively support high-risk patient profiles. 38:48 Specialized lab testing recommendations for preconception care based on mom's immune concerns and history of miscarriage. 42:00 Addressing concerns before conception based on the patient's ideal timeline. 44:05 Ari shares the teaching and personal experiences that have shaped her compassion and desire to help parents find answers and solve the pieces of their child's puzzle. 46:18 Pro-resolving mediators can be used in high doses for infection and injury in pregnancy as well as for children with autism. 47:52 The danger of low zinc-to-copper ratios and the mechanisms behind the imbalanced levels. 54:32 Supplementing with zinc and other supplements can be the easy solution to most copper imbalance-related issues. 55:20 Ari highlights the training and experience that she has gained in these little-researched topics. 58:10 Ari shares her top three supplements, her evolving health practices around diet, sleep, and exercise, and the dairy-free idea that she has changed her mind about.
BUFFALO, NY- May 8, 2024 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 8, entitled, “The association between neighborhood deprivation and DNA methylation in an autopsy cohort.” Previous research has found that living in a disadvantaged neighborhood is associated with poor health outcomes. Living in disadvantaged neighborhoods may alter inflammation and immune response in the body, which could be reflected in epigenetic mechanisms such as DNA methylation (DNAm). In this new study, researchers Lindsay Pett, Zhenjiang Li, Sarina Abrishamcar, Kenyaita Hodge, Todd Everson, Grace Christensen, Marla Gearing, Michael S. Kobor, Chaini Konwar, Julia L. MacIsaac, Kristy Dever, Aliza P. Wingo, Allan Levey, James J. Lah, Thomas S. Wingo, and Anke Hüls from Emory University, University of British Columbia, BC Children's Hospital Research Institute, Centre for Molecular Medicine and Therapeutics, and Atlanta VA Medical Center used robust linear regression models to conduct an epigenome-wide association study examining the association between neighborhood deprivation (Area Deprivation Index; ADI), and DNAm in brain tissue from 159 donors enrolled in the Emory Goizueta Alzheimer's Disease Research Center (Georgia, USA). “We found one CpG site (cg26514961, gene PLXNC1) significantly associated with ADI after controlling for covariates and multiple testing (p-value=5.0e-8).” Effect modification by APOE ε4 was statistically significant for the top ten CpG sites from the EWAS of ADI, indicating that the observed associations between ADI and DNAm were mainly driven by donors who carried at least one APOE ε4 allele. Four of the top ten CpG sites showed a significant concordance between brain tissue and tissues that are easily accessible in living individuals (blood, buccal cells, saliva), including DNAm in cg26514961 (PLXNC1). This study identified one CpG site (cg26514961, PLXNC1 gene) that was significantly associated with neighborhood deprivation in brain tissue. PLXNC1 is related to immune response, which may be one biological pathway how neighborhood conditions affect health. “The concordance between brain and other tissues for our top CpG sites could make them potential candidates for biomarkers in living individuals.” DOI - https://doi.org/10.18632/aging.205764 Corresponding author - Anke Hüls - anke.huels@emory.edu Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.205764 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts About Aging-US Aging publishes research papers in all fields of aging research including but not limited, aging from yeast to mammals, cellular senescence, age-related diseases such as cancer and Alzheimer's diseases and their prevention and treatment, anti-aging strategies and drug development and especially the role of signal transduction pathways such as mTOR in aging and potential approaches to modulate these signaling pathways to extend lifespan. The journal aims to promote treatment of age-related diseases by slowing down aging, validation of anti-aging drugs by treating age-related diseases, prevention of cancer by inhibiting aging. Cancer and COVID-19 are age-related diseases. Please visit our website at https://www.Aging-US.com and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM
Older-shmolder! How taking control of your biological age can help you live longer, better. This episode is going to have something for everyone in your life. From the food you eat and daily habits you have, you will findout how to reverse your old age before it even happens. My Guest Dr. Kara Fitzgerald is an award-winning clinical researcher of biological age reversal using a diet and lifestyle intervention developed in her virtual and in-person Functional Medicine clinic. She is the author of the book, Younger You and Program based on her ground-breaking 8-week clinical study and follow up case series that resulted in a 3-year and 4.6-year average reversalof biological aging, respectively. She also has a Younger You companion cookbook, Better Broths and Healing Tonics. Dr. Fitzgerald is an educator at the Institute for Functional Medicine(IFM), and is an IFM Certified Practitioner. She regularly lectures internationally and hosts the podcast New Frontiers in Functional Medicine. Questions We Answer in This Episode: What prompted you to write this book (Younger You: Reduce Your Bio Age and Live Longer, Better? [00:03:36] What is DNA Methylation? [00:09:19] Why should you include mushrooms in your diet? [00:14:15] Which is more advantageous when it comes to biological age? Plant-based or animal-based products? [00:16:44] Talk to me a little bit about exercise. So what did you find was key? [00:23:38] How important is joy? [00:26:59] That period of time you were going through a really hard time. Is there any equivalent to that with resilience in life? [00:31:29] Connect with Dr. Kara Website: You can keep up-to-date with Dr. Fitzgerald's work and programs by joining her e-newsletter list here https://www.drkarafitzgerald.com On Social: On Social: Facebook: https://www.facebook.com/DrKaraFitzgerald/ Instagram: https://www.instagram.com/drkarafitzgerald/?hl=en LinkedIn: https://www.linkedin.com/in/dr-kara-fitzgerald-b77265b Twitter: https://twitter.com/kfitzgeraldnd?ref_src=twsrc^google|twcamp^serp|twgr^author Other Episodes You Might Like: The ABCs of Metabolic Mastery for Midlife Women https://www.flippingfifty.com/metabolic-mastery/ What Are the Real Secrets to Longevity? https://www.flippingfifty.com/real-secrets-to-longevity/ Low Energy Availability in Menopause? Eating Too Little to Feel Good or Age Well https://www.flippingfifty.com/low-energy-availability-in-menopause/ Resources Resources: YOUNGER YOU: https://youngeryouprogram.com/book/ https://drive.google.com/file/d/1sH9mkOeXhBDRryJwsQjOKIV34QOMg2rT/view?usp=drive_linkhttps:///www.flippingfifty.com/getstronger
Explore the intriguing intersection of diet, lifestyle, and longevity in episode #293, featuring renowned cardiologist and epidemiologist Dr. Gary Fraser. As a distinguished professor with a unique perspective from his long-standing involvement in the Seventh-day Adventist Church, Dr. Fraser brings a wealth of knowledge on the impact of vegetarian diets and lifestyle choices on health outcomes. In our discussion, we delve into the fascinating findings from his extensive research, uncovering the nuanced ways our dietary habits influence our well-being and life expectancy. While Dr. Fraser sheds light on the complex world of nutritional science, we also touch upon the interplay of faith, health, and scientific objectivity, offering a thought-provoking blend of professional insights and personal beliefs. Tune in for an episode that promises to enlighten and challenge your understanding of the profound relationship between what we eat and how we live. We discuss: Intro (00:00) Discovering Gary Frazier's Scientific Career (02:04) What Influences a Scientist's Change of Mind? (08:17) How to Avoid Bias in Nutritional Data Analysis (15:07) Exploring the Seventh-Day Adventist Perspective on Nutrition and Lifestyle (20:46) Investigating Longevity in Vegetarians and Non-Vegetarians within the Seventh-Day Adventist Community (25:13) Comparing Health and Longevity: Seventh-Day Adventists vs Average Americans (29:59) Analysing Body Weight Differences: Adventists vs Typical Americans (33:30) Muscle Mass and Bone Density: Insights from the Seventh-Day Adventist Population (39:38) The Impact of Protein Consumption and Physical Activity on Strength (44:16) Dietary Variations Among Seventh-Day Adventist Women and Men (48:14) Evaluating the Risks and Benefits of Dairy Food Consumption (51:35) The Impact of Long-Term Diets on Health (1:05:15) Omega 3 Supplementation vs Fatty Fish: What Does Research Indicate? (1:07:19) An Introduction to the Seventh-Day Adventist Church (1:09:00) Uncovering the Story of John Harvey Kellogg (1:12:56) Exploring the Link Between Plant-Based Diet Patterns and Reproductive Health (1:16:36) The Role of the Seventh-Day Adventist in the Battle Creek Sanitarium (1:20:58) Gary Frazier: A Scientist Embracing Seventh-Day Adventist Beliefs (1:24:58) Addressing Major Criticisms of Gary Frazier's Nutrition Research (1:30:24) Diet Comparisons: Adventist Vegetarians vs EPIC-Oxford and British Vegetarians (1:34:49) Assessing Diet Quality in Adventists: Vegans, Vegetarians, and Non-Vegetarians (1:39:31) The Role of DNA Methylation in Diet and Health (1:44:26) Identifying Main Mechanisms Behind Health Outcomes (1:47:03) Investigating Dietary Patterns in Adventists: A Study on Lupus Correlation (1:48:55) Delving into Additional Research on the Seventh-Day Adventist Diet (1:52:08) What Does Adventist Diet Research Reveal About Dairy? (1:54:53) Identifying the Most Significant Dietary Change for American Health and Longevity (2:00:53) Where is the Future Heading in Diet Studies for Ultimate Human Health? (2:05:10) Outro (2:10:59) Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Author of The Proof is in the Plants Watch the episodes on YouTube or listen on Apple/Spotify Connect with me on Instagram, Twitter, and Facebook Nourish your gut with my Plant-Based Ferments Guide Download my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book
In this Papers Podcast, Dr. Charlotte Cecil and Dr. Mannan Luo discusses their co-authored JCPP paper ‘DNA methylation at birth and lateral ventricular volume in childhood: a neuroimaging epigenetics study'.
The reliability of testing epigenetic DNA methylation using Illumina beadchips is of paramount importance due to the specific intricacies of this technology. Illumina beadchips are widely used platforms for high-throughput epigenetic analysis, employing thousands of probes to measure DNA methylation levels at specific genomic loci. In this week's Everything Epigenetics podcast, Dr. Karen Sugden and I talk about how the reliability of these probes directly impacts the accuracy and validity of the results obtained.Keep in mind that in the context of Illumina beadchips, reliability refers to the consistent and accurate performance of each individual probe across multiple samples and experimental replicates. Each probe is designed to target a specific CpG site, and the methylation signal it generates must be dependable and reproducible.We discuss how reliable probes ensure the accuracy of DNA methylation measurements and how the reliability of probes becomes crucial for reproducibility when conducting large-scale studies using Illumina beadchips, such as epigenome-wide association studies (EWAS).Dr. Sugden and I also discuss how the reliability of probes on Illumina beadchips has implications for cross-study comparisons. For example, if the probes exhibit inconsistent behavior across different experiments or cohorts, it becomes challenging to compare results and draw meaningful insights from combined analyses.Furthermore, we chat about the efficient utilization of resources being linked to probe reliability. Unreliable probes might necessitate repeating experiments or allocating additional resources to validate results, potentially delaying research progress and increasing costs.In the context of epigenetic research, where subtle changes in DNA methylation can hold profound biological significance, the accuracy and consistency of data generated by Illumina beadchips are pivotal. Lastly, we explore Dr. Sugden's current research which includes how epigenetic clocks are associated with cognitive impairment and dementia and marijuana use. In this episode of Everything Epigenetics, you'll learn about: Dr. Karen Sugden's career Reliability and why it mattersHow unreliability arises in epigenetic researchThe process of measuring DNA methylation on Illumina beadchips (or microarrays) Technical errors that could arise when looking at DNA methylationKaren's paper titled “Patterns of Reliability: Assessing the Reproducibility and Integrity of DNA Methylation Measurement”How to untangle data from different beadchips (27K vs. 450K vs. EPIC 850K)What constitutes a reliable probe vs. an unreliable probe How to handle unreliable probesWho is at fault for unreliable probes If reliability is the same for every beadchipHow unreliability impacts epigenetic research How we can deal with unreliabilityThe value of repeated data Creating a “gold standard” work flow for processing epigenetic data How epigenetic clocks associate with cognitive impairment and dementia The connection between epigenetic clocks and marijuanaDr. Sugden's current research investigations Karen Sugden's profile at Duke - https://moffittcaspi.trinity.duke.edu/karen-sugden-0Support the showThank you for joining us at the Everything Epigenetics Podcast and remember you have control over your Epigenetics, so tune in next time to learn more about how.
In this can't-miss episode, Buck engages in a riveting conversation with the Dr. Joel Rothman, the Founding Director at UCSB's Center for Aging and Longevity Studies (CALS). Prepare to be transported into the cutting-edge world of scientific discoveries that are reshaping our understanding of aging, potentially unlocking the secrets to unprecedented human longevity. This is only the beginning! Be sure to catch the continuation of this talk in episode 33, where we delve even deeper into the groundbreaking breakthroughs at the frontier of aging research including the research being done at CALS. 00:02:24 - The Science of Aging: A Deeper Dive 00:04:34 - The Human Lifespan 00:07:04 - The Different Lifespans of Organisms 00:09:12 - Aubrey de Grey Longevity Escape Velocity 00:12:27 - The Brain and Aging 00:13:47 - David Sinclair's Book Lifespan 00:14:23 - The Role of Epigenome in Aging 00:19:10 - Genes and Epigenome 00:20:41 - DNA Methylation and Chromosome Structure 00:22:02 - Information Theory of Aging 00:24:14 - Proteostasis or removal of defective proteins 00:26:17 - The Horvath Clock and Biological Clocks 00:30:50 - Epigenome Reset 00:33:53 - Yamanaka Factors 00:37:00 - Extending Healthspan through Cocktails 00:41:44 - Challenges in Drug Development
In this weeks episode of "Pushing the Limits" Lisa gets to talk to a world leading anti-aging and longevity expert Dr Bill Lawrence who himself is 77 years old but has the telomere length (we explain what that aging biomarker in the show) of someone in their thirties. Dr. Lawrence has a Jurisprudence Degree (UCLA-Law), an MS in Psychology and a Ph.D. in Nutrition. Since 1990 his focus has been on slowing and reversing human biological aging. He has developed numerous science-based protocols focused on optimal aging for health professionals and individual clients. Presently Dr. Lawrence is the administrator of two clinical studies to determine if human biological age can be reversed in collaboration with Dr Vladimir Khavinson of the Saint-Petersburg Institute of Bioregulation and Gerontology Dr Lawrence shares in this episode a presentation of the current study data (note the trial is still ongoing) and the exciting proof we can now REVERSE aging and promote long and healthier lives and reduce our risk of morbidity and mortality using Bioregulators The science behind this is impressive and it's human trials. Dr Lawrence is reinforcing through his findings the research of Professor Khavinson who has been working on Bioregulators and doing the research on these for over 5 decades. I am excited to share this cutting edge information with you and to get going myself on the Bioregulators. BIO BILL LAWRENCE JD. MS, Ph.D. Dr. Lawrence is an American biogerontologist with a Jurisprudence Degree (UCLA-Law), an MS in Psychology, and a Ph.D. in Nutritional Science. For three decades, his focus has been human longevity research and interventions for optimal life and healthspan. He is the administrator of two Russian and American longevity clinical studies: Telomerase activation and DNA/Methylation modification. These studies use Khavinson Peptide Bioregulators developed by Prof. Vladimir Khavinson of the St. Petersburg Institute, for organ regeneration, mortality reduction and reversal of human aging biomarkers. In his presentation, Dr. Lawrence, as a scientist, will report clinical study data and, as an attorney, evidence confirming Peptide Bioregulators are the only proven interventions supported by human studies that accomplish the above. Dr. Lawrence is chronologically 77. His average telomere length, or “Cellular Age” is equivalent to a 23-year-old. His “Epigenetic Age” measured by the Horvath Epigenetic Clock (DNA/Methylation) reports a fifty percent reduction of all-cause mortality risk compared to his same-age peers. Health Optimisation and Life Coaching with Lisa Tamati Lisa offers solution focused coaching sessions to help you find the right answers to your challenges. Topics Lisa can help with: Lisa is a Genetics Practitioner, Health Optimisation Coach, High Performance and Mindset Coach. She is a qualified Ph360 Epigenetics coach and a clinician with The DNA Company and has done years of research into brain rehabilitation, neurodegenerative diseases and biohacking. She has extensive knowledge on such therapies as hyperbaric oxygen, intravenous vitamin C, sports performance, functional genomics, Thyroid, Hormones, Cancer and much more. 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Please join our patron community and get exclusive member benefits (more to roll out later this year) and support this educational platform for the price of a coffee or two You can join by going to Lisa's Patron Community Lisa's Anti-Aging and Longevity Supplements Lisa has spent years curating a very specialised range of exclusive longevity, health optimising supplements from leading scientists, researchers and companies all around the world. This is an unprecedented collection. The stuff Lisa wanted for her mum but couldn't get in NZ. Check out the range at her LongLifeLabs shop Subscribe to our popular Youtube channel with over 600 videos, millions of views, a number of full length documentaries, and much more. You don't want to miss out on all the great content on our Lisa's youtube channel. Youtube Order Lisa's Books My latest book Relentless chronicles the inspiring journey of how my mother and I defied the odds after an aneurysm left my mum, Isobel, with massive brain damage at age 74. The medical professionals told me there was absolutely no hope of any quality of life again. Still, I used every mindset tool, years of research and incredible tenacity to prove them wrong and bring my mother back to full health within three years. Order your copy here: RELENTLESS - How A Mother & Daughter Defied The Odds Our NMN Bio Flagship Longevity Range A range by molecular biologist Dr Elena Seranova NMN: Nicotinamide Mononucleotide, an NAD+ precursor Researchers have found that Nicotinamide Adenine Dinucleotide or NAD+, a master regulator of metabolism and a molecule essential for the functionality of all human cells, decreases dramatically over time. What is NMN? 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The coated PerfectAmino tablets are a slightly different shape and have a natural, non-GMO, certified organic vegan coating on them so they will glide down your throat easily. Fully absorbed within 20-30 minutes! No other form of protein comes close to PerfectAminos Listen to the episode with Dr MInkoff here: Ketone Products by HVMN The world's best exogenous Ketone IQ Listen to the episode with Dr Latt Mansor Lisa's ‘Fierce' Sports Jewellery Collection For Lisa's gorgeous and inspiring sports jewellery collection, 'Fierce', go to Jewellery For Vielight Device Vielight brain photobiomodulation devices combine electrical engineering and neuroscience. To find out more about photobiomodulation, current studies underway and already completed and for the devices mentioned in this video go to www.vielight.com Use code "tamati" at checkout to get a 10% discount on any of their devices. Enjoyed This Podcast? If you did, subscribe and share it with your friends! 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While exercise helps us stay healthy, what is happening on the molecular level? Matthew A. Romero, Ph.D., shares his work to understand how muscle in general and other cells specifically are transcriptionally regulated by exercise and how this affects their general behavior and how this is impacted by diseases such as obesity. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39033]
While exercise helps us stay healthy, what is happening on the molecular level? Matthew A. Romero, Ph.D., shares his work to understand how muscle in general and other cells specifically are transcriptionally regulated by exercise and how this affects their general behavior and how this is impacted by diseases such as obesity. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39033]
While exercise helps us stay healthy, what is happening on the molecular level? Matthew A. Romero, Ph.D., shares his work to understand how muscle in general and other cells specifically are transcriptionally regulated by exercise and how this affects their general behavior and how this is impacted by diseases such as obesity. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39033]
While exercise helps us stay healthy, what is happening on the molecular level? Matthew A. Romero, Ph.D., shares his work to understand how muscle in general and other cells specifically are transcriptionally regulated by exercise and how this affects their general behavior and how this is impacted by diseases such as obesity. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39033]
While exercise helps us stay healthy, what is happening on the molecular level? Matthew A. Romero, Ph.D., shares his work to understand how muscle in general and other cells specifically are transcriptionally regulated by exercise and how this affects their general behavior and how this is impacted by diseases such as obesity. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39033]
In this episode of the Epigenetics Podcast, we caught up with Paula Desplats from the University of California San Diego to talk about her work on DNA Methylation Alterations in Neurodegenerative Diseases. The laboratory of Paula desalts focuses on decoding the role of epigenetic mechanisms, like DNA methylation, on the onset and progression of neurodegenerative diseases like Parkinson's and Alzheimer's. In doing so, on of the goals of the Desplats team is to develop a biomarker panel based on quantification of DNA methylation of selected genes that can discriminate Parkison's Disease patients from healthy subjects in a simple blood test. More recently, the team also focused on the role of the circadian rhythm on neurodegenerative diseases and finding a way how interventions can help in managing the disease. References Masliah, E., Dumaop, W., Galasko, D., & Desplats, P. (2013). Distinctive patterns of DNA methylation associated with Parkinson disease: identification of concordant epigenetic changes in brain and peripheral blood leukocytes. Epigenetics, 8(10), 1030–1038. https://doi.org/10.4161/epi.25865 Cronin, P., McCarthy, M. J., Lim, A., Salmon, D. P., Galasko, D., Masliah, E., De Jager, P. L., Bennett, D. A., & Desplats, P. (2017). Circadian alterations during early stages of Alzheimer's disease are associated with aberrant cycles of DNA methylation in BMAL1. Alzheimer's & dementia : the journal of the Alzheimer's Association, 13(6), 689–700. https://doi.org/10.1016/j.jalz.2016.10.003 Henderson-Smith, A., Fisch, K. M., Hua, J., Liu, G., Ricciardelli, E., Jepsen, K., Huentelman, M., Stalberg, G., Edland, S. D., Scherzer, C. R., Dunckley, T., & Desplats, P. (2019). DNA methylation changes associated with Parkinson's disease progression: outcomes from the first longitudinal genome-wide methylation analysis in blood. Epigenetics, 14(4), 365–382. https://doi.org/10.1080/15592294.2019.1588682 Nasamran, C. A., Sachan, A., Mott, J., Kuras, Y. I., Scherzer, C. R., Study, H. B., Ricciardelli, E., Jepsen, K., Edland, S. D., Fisch, K. M., & Desplats, P. (2021). Differential blood DNA methylation across Lewy body dementias. Alzheimer's & dementia (Amsterdam, Netherlands), 13(1), e12156. https://doi.org/10.1002/dad2.12156 Related Episodes Development of Integrative Machine Learning Tools for Neurodegenerative Diseases (Enrico Glaab) The Role of DNA Methylation in Epilepsy (Katja Kobow) CpG Islands, DNA Methylation, and Disease (Sir Adrian Bird) Contact Epigenetics Podcast on Twitter Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Active Motif on Twitter Active Motif on LinkedIn Email: podcast@activemotif.com
The Case: Laura has thyroid issues causing her to feel overweight and her constantly dry skin made her feel like she was aging too fast. She suspected that her issues might be genetic so she did a DNA test which revealed that she had the MTHFR gene. She tried biohacking; taking high doses of B vitamins and a cocktail of other supplements but nothing got her the results she was looking for. Investigation My suspicions were that her various supplements might not be right for her. I also wanted to take a closer look at her diet and lifestyle. Because I suspected that the answers were going to be found at the intersection of genetics, diet, and lifestyle I knew that Dr. Kara Fitzgerald would be the perfect person to consult with since she is an expert in epigenetics, nutrition, and aging. She is the author of two incredible books, Younger You: Reduce Your Bio Age and Live Longer, Better and Better Broths & Healing Tonics: 75 Bone Broth and Vegetarian Broth-Based Recipes for Everyone. Unveiling the Power of Epigenetics We often associate our health, thyroid function, and immune system with genetics and autoimmunity. However, as Dr. Kara explains, it is not our genes alone that determine our level of health, immune system function, or even our age. Instead, it is our epigenetics that play a significant role. I know there's a lot of confusion surrounding this topic, and in this episode, Dr. Kara shed some light on it. She explains that in the early 2000s, scientists successfully deciphered the human genome. They discovered that we possess a little over 23,000 genes, and many believed that this knowledge would provide a clear roadmap to understanding and treating diseases. However, the reality turned out to be quite different. In over 90% of cases, genes alone do not determine our health outcomes. For most of us, the key lies in how our genes are being turned on and off—a fascinating field known as epigenetics that we've covered before in episode 143. Unleashing the Potential of Epigenetic Expression Epigenetics emerged as a prominent field of study after the completion of the Human Genome Project. It explores the factors that influence gene expression, such as our diet, exposure to toxins, stress levels, social connections, and exercise habits. Simply put, we have the power to determine which genes are activated and which ones remain dormant. Ideally, we want to activate the genes associated with health, longevity, and overall well-being while silencing those that contribute to disease progression. This realization is particularly empowering for individuals like Laura, who believed that her family history of Hashimoto's meant she was destined to follow the same path. However, epigenetics shows us that we are not bound by our genetic heritage alone. Lifestyle and Nutrition: The Epigenetic Keys Dr. Kara dives into the exciting realm of lifestyle and nutrition, revealing some of the most significant factors that influence gene expression. Understanding these keys can help us unlock the potential for anti-aging, detoxification, and disease prevention. 1. Diet Program: Dr. Kara shares insights from a groundbreaking study on biological aging, which focused on DNA methylation—a marker of aging and gene expression changes. The study participants followed a specific diet program designed to optimize gene expression. The key elements of this diet program include: Veggies and Greens: Emphasizing a plant-rich diet with an abundance of greens and cruciferous vegetables, cooked to support thyroid health. Low-Glycemic and Fruit-Dense: Opting for low-glycemic vegetables and incorporating dark berries rich in polyphenols. Smart Protein Choices: Eggs and liver (if open to consuming them) are excellent gene whispering foods, while seeds, nuts, and fatty fish provide essential nutrients. Healthy Oils: Including extra virgin olive oil and coconut oil in cooking. Vitamin D and Mushrooms: Ensuring sufficient vitamin D intake and recognizing the gene-regulating properties of mushrooms, such as shiitake and maitake. 2. Herbs and Spices: Dr. Kara highlights the impact of polyphenols found in various herbs and spices. Rosemary, thyme, oregano, curcumin, turmeric, quercetin, and resveratrol are just a few examples of potent gene regulators. It's important to note that while we may inherit some gene expression patterns from our parents and ancestors, we still hold the reins and have the power to influence our health destiny. Understanding this gives us the opportunity to make informed choices and take control of our well-being. Dr. Kara emphasizes the vital connection between epigenetics, aging, and thyroid disease. Aging acts as a primary driver for various chronic conditions, including hypothyroidism, Graves' disease, and subclinical hypothyroidism. Exploring the changes in epigenetic expression and DNA methylation provides valuable insights into the underlying mechanisms of these conditions. Epigenetic Lifestyle: A Holistic Approach to Optimal Health Dr. Kara uses her study and others as examples to showcase that it's not just about individual foods but a synergistic combination that maximizes the effects on gene expression. She explains that her program incorporates low glycemic choices, intermittent fasting, exercise, and other crucial lifestyle factors. The Power of Simple Lifestyle Changes Dr. Kara says the key to success is by making simple, doable lifestyle changes to improve our health and slow down the aging process. She emphasizes that the goal is not to engage in extreme measures but rather to focus on sustainable habits that can positively impact our overall well-being. That was the motivation behind her research team's design of a program called "Younger You" that aimed to create meaningful changes in participants' health. The program included a simple exercise prescription, prioritized quality sleep, incorporated basic meditation practices, and recommended the use of a greens powder and probiotic supplement. The results she shared were truly astonishing to me. Understanding the Role of DNA Methylation DNA methylation plays a crucial role in gene expression and epigenetics. We've talked about this before (on this episode about the MTHFR gene) but it's important to go beyond that. Methylation is involved in numerous essential processes in the body, from metabolizing hormones and neurotransmitters to maintaining optimal cell function. Methylation is influenced by various factors, including nutrients, gut health, and the microbiome. Comprehensive testing is needed to assess methylation status and overall metabolic function. This involves looking at biomarkers such as homocysteine and methylation cycle intermediates. A functional medicine approach goes beyond the methylation cycle and explores other metabolic aspects, including gut health and individual nutrient needs. By understanding each person's unique metabolic profile, personalized interventions can be implemented to optimize health and well-being. However, before diving deeper into methylation, Dr. Kara offered a bit of a caveat: it's important not to focus too much on genetics as it can cause anxiety. Dr. Kara says that our genes do not determine our destiny. Other tests, such as the organic acid test can help us paint a bigger picture of what's going on and allow us to use a more holistic approach to solving health mysteries. DNA Methylation and Disease Risk There are two things to consider with methylation: overmethylation (hypermethylation) and undermethylation (hypomethylation). However, Dr. Kara clarified that these are not necessarily the phenomena that regulate gene expression through epigenetics and DNA methylation. Methylation patterns can be complex, and it is crucial to consider the context and specific genes involved. Dr. Kara says her study demonstrates that lifestyle interventions, particularly dietary changes, can positively influence DNA methylation patterns. Contrary to the popular belief of simply increasing methylation, it is about directing the methylation process to beneficial areas. She emphasizes the role of exercise, sleep, stress management, and toxin avoidance as critical epi nutrients that regulate DNA methylation. These lifestyle factors work in harmony with dietary interventions to support optimal methylation. The study's outcomes highlight the body's remarkable ability to heal and rebalance when provided with the right tools. Dr. Kara emphasizes that it is not about overwhelming the body with numerous supplements but rather making meaningful changes in our diet and lifestyle. These changes can have a profound impact on rebalancing methylation and gene expression. Implications for Thyroid Autoimmunity Like Laura, many of you are dealing with hypothyroidism, Hashimoto's, and autoimmunity so I wanted to dive deeper into the role of imbalanced methylation. Dr. Kara shares that certain genetic variations and imbalances in methylation can contribute to the development of autoimmune thyroid conditions such as Hashimoto's, thyroiditis, and Graves' disease. Understanding and addressing methylation imbalances can be a valuable aspect of a comprehensive approach to managing thyroid health. Testing methylation markers and tailoring interventions based on individual needs can lead to more targeted and successful outcomes. Happy Ending Knowing that DNA methylation has a huge impact on immune system health and overall health, I knew we had to take that into account in our holistic approach to dealing with Laura's health mystery. We started by focusing on her diet. She wasn't eating well and was relying on vitamins to make up for her nutritional shortages but she was overdoing it. To correct this, we did a phasic approach where first we removed lectins and then moved to a grain-free diet. We then slowly added different foods back in. At that point, we did some testing through organic acids and micronutrients. She was already feeling a lot better and that is when we started adding the nutrients that were most beneficial for her based on the results of her testing. Eliminating Health Mysteries For Laura, we were able to find that missing piece of the health puzzle and help her regain her health. Could this be the missing clue for you or someone in your life? Links: Resources mentioned Thanks to my guest Dr. Kara Fitzgerald. You can learn more about her programs and research on her website or connect with her on Instagram. The book we discussed is Younger You: Reduce Your Bio Age and Live Longer, Better Related Podcast Episodes: 108 The Case of Fatigue and Brain Fog Made Worse by B Vitamins 34 The Case of Unrelenting Depression and Anxiety w/ Dr. Loren Marks 143 Your Family History Goes Beyond Genetics: A Novel Way to Look at Hashimoto's Thanks for Listening If you like what you heard, please rate and review this podcast. Every piece of feedback not only helps me create better shows, it helps more people find this important information. Never miss an episode - Subscribe NOW to Health Mysteries Solved with host, Inna Topiler on Apple Podcasts, Spotify, Stitcher or Google Podcasts and remember to rate and review the show! Find out more at http://healthmysteriessolved.com PLEASE NOTE All information, content, and material on this podcast is for informational purposes only and is not intended to serve as a substitute for the consultation, diagnosis, and/or medical treatment of a qualified physician or healthcare provider. Some of the links provided are affiliate links. This means we may make a very small amount of money should you choose to buy after clicking on them. This will in no way affect the price of the product but it helps us a tiny bit in covering our expenses.
References Cancers (Basel). 2019 May; 11(5): 678. Oncogene.2017 Mar 23; 36(12): 1607–1618 Dr Guerra's annotated lecture notes from graduate biochemistry course(s) --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message
Health is wealth. When you don't feel physically well, it is challenging to follow and live your purpose. Today's guest, Tara Smith, knows this truth from the very core of her being. After overcoming her own set of health challenges and life events, she is now dedicating her life to help others on their healing journeys.How to get in touch with TaraTara's IGTara's email: tara.smith@advancedrejuvenation.usSchedule 20 min initial consultation hereAdvanced Rejuvenation ClinicAll the supplements mentioned can be found here (Use discount code “tarasmith” and get 5% off!)Resources discussed in this episode:Dr. John LieuranceKensho Studio - Breathwork + Cold PlungeWhat is Lyme Disease?What is Methylene Blue?Sauna SpaceGlutaStatMeditation MistDr. Joe DispenzaDr. Bruce LiptonWhat is SIBO?Peter Attia - The Science and Art of LongevityWhat is DNA Methylation?What are Peptides?**A few of my favorite things**My dear friend, Orly (yes, the owner of online home decor store, Lara & Lou) is offering a course From Intuition to Fruition - Tap into your intuition and create your heart's desires. This 6-week course starts on May 3rd, and the early bird pricing ends on Saturday, April 22nd! You can Listen to Orly's episode and learn her background as a spiritual medium. Let's connect!Facebook group: https://www.facebook.com/groups/151528407196525Instagram: https://www.instagram.com/whynotmeditate.podcast/Website: https://masakozawa.com/Download "5 steps to start your meditation practice" for free today! https://www.subscribepage.com/5_steps_to_start_your_meditation_practice**Thinking about starting your own podcast? Use my buzzsprout link and receive a $20 credit when you sign up for a paid plan!**Support the show
On this episode we geek out with a true Epigentic expert, Hanna Went. Hannah Went is epigenetics enthusiast and the Director of Operations at TruDiagnostic. She has helped implement large-scale methylation testing for clinical practices and is a co-author of several upcoming studies about interventions to address biological aging. We go into DNA Methylation, Exosomes, Peptides, Stem Cell, nutrients and supplements to name a few. This one is super geeky but very informative.
In this episode of the Epigenetics Podcast, we caught up with Sarah Kimmins from Université de Montreal to talk about her work on the epigenetics of human sperm cells. The focus of Sarah Kimmins and her lab is how sperm and offspring health is impacted by the father's environment. The core of this is the sperm epigenome, which has been implicated in complex diseases such as infertility, cancer, diabetes, schizophrenia and autism. The Kimmins lab is interested which players play a role in this and came across the Histone post-translational modification H3K4me3. In this interview we talk about how the father's life choices can impact offspring health, which can also be inherited transgenerationally and how this can be used to develop intervention strategies to improve child and adult health. References Siklenka, K., Erkek, S., Godmann, M., Lambrot, R., McGraw, S., Lafleur, C., Cohen, T., Xia, J., Suderman, M., Hallett, M., Trasler, J., Peters, A. H., & Kimmins, S. (2015). Disruption of histone methylation in developing sperm impairs offspring health transgenerationally. Science (New York, N.Y.), 350(6261), aab2006. https://doi.org/10.1126/science.aab2006 Lismer, A., Siklenka, K., Lafleur, C., Dumeaux, V., & Kimmins, S. (2020). Sperm histone H3 lysine 4 trimethylation is altered in a genetic mouse model of transgenerational epigenetic inheritance. Nucleic acids research, 48(20), 11380–11393. https://doi.org/10.1093/nar/gkaa712 Lismer, A., Dumeaux, V., Lafleur, C., Lambrot, R., Brind'Amour, J., Lorincz, M. C., & Kimmins, S. (2021). Histone H3 lysine 4 trimethylation in sperm is transmitted to the embryo and associated with diet-induced phenotypes in the offspring. Developmental cell, 56(5), 671–686.e6. https://doi.org/10.1016/j.devcel.2021.01.014 Related Episodes H3K4me3, SET Proteins, Isw1, and their Role in Transcription (Jane Mellor) The Effects of Early Life Stress on Mammalian Development (Catherine J. Peña) DNA Methylation and Mammalian Development (Déborah Bourc'his) Contact Epigenetics Podcast on Twitter Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Active Motif on Twitter Active Motif on LinkedIn Email: podcast@activemotif.com
Ryan Smith is the founder of TruDiagnostic, a commercial testing system that tests your biological age, as opposed to your chronological age. It's can be a profoundly useful tool, because you need an objective barometer to tell you whether or not the things you're doing to improve your health are actually having the desired impact.
Today, Dr. Kara Fitzgerald joins me to talk about DNA Methylation. Life expectancy in the United States is on the decline. We are living for a shorter time and according to the World Health Organization, even though we have a life expectancy of 79.3 years, the average age for developing a serious illness is 63.1 years old. That means that we spend the last 16.2 years of our life ill. Aging is driven by DNA methylation, a process that influences which genes are turned on and which are turned off. We use DNA methylation as an epigenetic clock to measure biological age. DNA methylation changes as we age, to our detriment, and it's not just a surrogate marker of aging. DNA methylation appears to drive aging itself. Foods that could lower your biological age: Liver [or liver capsules] Eggs Mushrooms [shitake or enoki] Leafy greens Pumpkin seeds Blueberries Turmeric Dr. Kara Fitzgerald Bio: Kara Fitzgerald, ND, IFMCP, is engaged in clinical research on DNA methylation using a diet and lifestyle intervention developed in her virtual and in-person Functional Medicine clinic. She is the author of Younger You: Reduce Your Bio Age and Live Longer, Better, a ground-breaking work detailing an 8-week study that resulted in a 3-year reversal of biological aging, and the step-by-step program that will help you live better and longer. In her quest for personalized health care for all, she leads clients through her Younger You Program and has as a Younger You companion cookbook, Better Broths, and Healing Tonics. Dr. Fitzgerald is on faculty at the Institute for Functional Medicine [IFM] and is an IFM Certified Practitioner. She regularly lectures internationally and hosts the podcast New Frontiers in Functional Medicine. She received her doctorate in naturopathic medicine from the National University of Natural Medicine in Oregon and is in private practice in Sandy Hook, Connecticut. In this episode: How cancer hijacks our epigenetics. [4:25] Dr. Fitzgerald defines methylation and explains how it differs from DNA methylation. [9:05] Foods that are important to improve methylation. [15:45] Foods that seem to direct epigenetic traffic. [17:39] Lifestyle pieces that could favorably influence DNA methylation in addition to the diet. [19:33] Foods that could lower your biological age. [25:46] Studies show that people who drink coffee live longer. [27:44] How to exercise to help prevent aging. [30:32] Foods to avoid that could be pro-aging. [33:13] Supplements that are recommended for anti-aging. [40:10] A backdoor approach for those who do not tolerate supplements well. [44:00] Links and resources: Guest Social Media Links: Instagram: https://www.instagram.com/drkarafitzgerald/ Facebook: https://www.facebook.com/DrKaraFitzgerald/ Twitter: https://twitter.com/kfitzgeraldnd Relative Links for This Show:: Younger Your Program: https://youngeryouprogram.com/basa/ Follow Your Longevity Blueprint on Instagram | Facebook | Twitter | YouTube | LinkedIn Get your copy of the Your Longevity Blueprint book and claim your bonuses here Find Dr. Stephanie Gray and Your Longevity Blueprint online Follow Dr. Stephanie Gray on Facebook | Instagram | Youtube | Twitter | and LinkedIn Integrative Health and Hormone Clinic Podcast production by Team Podcast
Dr. Evan Noch interviews Drs. Richard Drexler and Franz Ricklefs about their recent manuscript entitled: "DNA methylation subclasses predict the benefit from gross total tumor resection in IDH-wildtype glioblastoma patients", published online in Neuro-Oncology in July 2022. Full Report
References Dr Guerra EtOH lectures Dr Guerra Reward Pathway lectures Biol Psychiatry. 2020 Jan 1; 87(1): 64–73 Biochemistry and Cell Biology. 2019. Volume 97, Number 4.August. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message
Our biology certainly influences our health and behavior, but the environment can also have a significant impact on our health and well-being. Thanks to the fascinating field of epigenetics, we now understand that factors like our nutrition, movement habits, stress levels, and feelings of emotional connection can affect the way our genes are expressed. So today host Rachel dips her toes into the world of science to discuss epigenetics, mental health, and yoga with guest Valerie Knopik. Valerie has a PhD in Psychology and postdoctoral training in Psychiatric and Genetic Epidemiology. Active in mental health research, Valerie has a deep interest in how our internal biology and our external environment (including yoga, mindfulness, and meditation) can interact to positively change our mental health landscape. In this episode, Valerie helps us understand how our genes alone don't determine our physical or mental health, what kind of environmental factors affect our epigenome, and how various yoga practices can make us more resilient to the environmental stressors we inevitably face. Show Notes: What got Valerie interested in science and biological psychology [3:28] Genetics versus epigenetics, how our “environment gets under the skin” [7:04] Defining epigenetics [11:23] Interrelating factors that influence our epigenetics [15:39] The varied roles yoga practice can play [21:19] What research says about the benefits of movement on our epigenome [23:22] Overlaps between the concepts of epigenetics and neural plasticity [29:59] The importance of supporting mental health; how yoga can help [31:43] Yoga practices for burnout [39:34] Valerie's key takeaways [43:57] Links Mentioned: Watch this episode on YouTube Mental Health & Wellness Yoga Teacher Training Recommended Articles: Epi-What? Change Your Internal Landscape Part 2: Epigenetics and How It Reduces Depression and Increases Longevity Światowy et al., “Physical Activity and DNA Methylation in Humans”: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657566/ Lindholm et al., “An integrative analysis reveals coordinated reprogramming of the epigenome and the transcriptome in human skeletal muscle after training” Yoga Medicine Online Burnout Series Yoga Medicine Online Monthly Dose: Mental Health Lecture Connect with Valerie Knopik: Instagram | Facebook | Twitter | Yoga Medicine Online Teacher You can learn more about this episode, and see the full show notes at YogaMedicine.com/podcast-49. And you can find out more about insider tips, online classes or information on our teacher trainings at www.YogaMedicine.com. To support our work, please leave us a 5 star review with your feedback on iTunes/Apple Podcasts.
In this episode of the Epigenetics Podcast, we caught up with Ben Delatte Research Scientist at Active Motif to talk about his work on Anchor Based Bisulfite Sequencing. Whole Genome Bisulfite Sequencing (WGBS) is the current standard for DNA methylation profiling. However, this approach is costly as it requires sequencing coverage over the entire genome. Here we introduce Anchor-Based Bisulfite Sequencing (ABBS). ABBS captures accurate DNA methylation information in Escherichia coli and mammals, while requiring up to 10 times fewer sequencing reads than WGBS. ABBS interrogates the entire genome and is not restricted to the CpG islands assayed by methods like Reduced Representation Bisulfite Sequencing (RRBS). The ABBS protocol is simple and can be performed in a single day. References Chapin, N., Fernandez, J., Poole, J. et al. Anchor-based bisulfite sequencing determines genome-wide DNA methylation. Commun Biol 5, 596 (2022). https://doi.org/10.1038/s42003-022-03543-1 Related Episodes The Role of DNA Methylation in Epilepsy (Katja Kobow) DNA Methylation and Mammalian Development (Déborah Bourc'his) Effects of DNA Methylation on Diabetes (Charlotte Ling) Contact Active Motif on Twitter Epigenetics Podcast on Twitter Active Motif on LinkedIn Active Motif on Facebook Email: podcast@activemotif.com
In this episode of the Epigenetics Podcast, we caught up with Susanne Mandrup from the University of Southern Denmark to talk about her work on the role of enhancer communities in adipocyte differentiation. The Laboratory of Susanne Mandrup focuses on the effect of enhancers and enhancer communities on the differentiation of mesenchymal stem cell into adipocytes and osteoblasts. The team has shown that there is significant cross-talk between enhancers and that these form communities of highly interconnected enhancers. Inactive enhancers are then activated by association with these pre-existing enhancer networks to facilitate gene expression in adipocyte differentiation. References Siersbæk R, Rabiee A, Nielsen R, Sidoli S, Traynor S, Loft A, Poulsen LC, Rogowska-Wrzesinska A, Jensen ON, Mandrup S. Transcription factor cooperativity in early adipogenic hotspots and super-enhancers. Cell Rep. 2014 Jun 12;7(5):1443-1455. doi: 10.1016/j.celrep.2014.04.042. Epub 2014 May 22. PMID: 24857652. Siersbæk R, Baek S, Rabiee A, Nielsen R, Traynor S, Clark N, Sandelin A, Jensen ON, Sung MH, Hager GL, Mandrup S. Molecular architecture of transcription factor hotspots in early adipogenesis. Cell Rep. 2014 Jun 12;7(5):1434-1442. doi: 10.1016/j.celrep.2014.04.043. Epub 2014 May 22. PMID: 24857666; PMCID: PMC6360525. Siersbæk R, Madsen JGS, Javierre BM, Nielsen R, Bagge EK, Cairns J, Wingett SW, Traynor S, Spivakov M, Fraser P, Mandrup S. Dynamic Rewiring of Promoter-Anchored Chromatin Loops during Adipocyte Differentiation. Mol Cell. 2017 May 4;66(3):420-435.e5. doi: 10.1016/j.molcel.2017.04.010. PMID: 28475875. Rauch, A., Haakonsson, A.K., Madsen, J.G.S. et al. Osteogenesis depends on commissioning of a network of stem cell transcription factors that act as repressors of adipogenesis. Nat Genet 51, 716–727 (2019). https://doi.org/10.1038/s41588-019-0359-1 Madsen, J.G.S., Madsen, M.S., Rauch, A. et al. Highly interconnected enhancer communities control lineage-determining genes in human mesenchymal stem cells. Nat Genet 52, 1227–1238 (2020). https://doi.org/10.1038/s41588-020-0709-z Related Episodes Ultraconserved Enhancers and Enhancer Redundancy (Diane Dickel) Effects of DNA Methylation on Diabetes (Charlotte Ling) Epigenetic Regulation of Stem Cell Self-Renewal and Differentiation (Peggy Goodell) Contact Active Motif on Twitter Epigenetics Podcast on Twitter Active Motif on LinkedIn Active Motif on Facebook Email: podcast@activemotif.com
In this episode of the Epigenetics Podcast, we caught up with Marcela Sjöberg from the University of Chile to talk about her work on the hydroxymethylation landscape in immune cells. At the beginning of her career Marcela Sjöberg worked on Polycomb and how modifications placed by this complex modulate the binding of RNA Pol II. Later, her focus shifted to hydroxymethylated cytosine and how it is involved in the inheritance of Metastable Epialleles in mouse. More recently, the laboratory is interested in transcription factor binding motifs and how hydroxymethylation of those binding motifs modulates the binding and activity of the respective transcription factors. References Sabbattini, P., Sjoberg, M., Nikic, S., Frangini, A., Holmqvist, P.-H., Kunowska, N., Carroll, T., Brookes, E., Arthur, S. J., Pombo, A., & Dillon, N. (2014). An H3K9/S10 methyl-phospho switch modulates Polycomb and Pol II binding at repressed genes during differentiation. Molecular Biology of the Cell, 25(6), 904–915. https://doi.org/10.1091/mbc.e13-10-0628 Kazachenka, A., Bertozzi, T. M., Sjoberg-Herrera, M. K., Walker, N., Gardner, J., Gunning, R., Pahita, E., Adams, S., Adams, D., & Ferguson-Smith, A. C. (2018). Identification, Characterization, and Heritability of Murine Metastable Epialleles: Implications for Non-genetic Inheritance. Cell, 175(5), 1259-1271.e13. https://doi.org/10.1016/j.cell.2018.09.043 Westoby, J., Herrera, M.S., Ferguson-Smith, A.C. et al. Simulation-based benchmarking of isoform quantification in single-cell RNA-seq. Genome Biol 19, 191 (2018). https://doi.org/10.1186/s13059-018-1571-5 Viner, C., Johnson, J., Walker, N., Shi, H., Sjöberg, M., Adams, D. J., Ferguson-Smith, A. C., Bailey, T. L., & Hoffman, M. M. (2016). Modeling methyl-sensitive transcription factor motifs with an expanded epigenetic alphabet [Preprint]. Bioinformatics. https://doi.org/10.1101/043794 Related Episodes The Role of DNA Methylation in Epilepsy (Katja Kobow) DNA Methylation and Mammalian Development (Déborah Bourc'his) Effects of DNA Methylation on Chromatin Structure and Transcription (Dirk Schübeler) Contact Active Motif on Twitter Epigenetics Podcast on Twitter Active Motif on LinkedIn Active Motif on Facebook Email: podcast@activemotif.com
In this episode, we welcome back Dr. Erika Gray (My Toolbox Genomics) to discuss the importance of DNA & Epigenetic testing for optimal health.LEARN MORE: https://www.mytoolboxgenomics.com (use code B&B7 at checkout) WHAT THIS EPISODE COVERS:What epigenetic testing reveals about skin health and cellular agingDark side of biohacking genetic testing (and data privacy)How My Toolbox Genomics works How does Epigenetics testing differ from DNA testing?Nature v. Nurture (and the role these play in genetic testing)What do you think is the most powerful way to support aging?ABOUT TOOLBOX GENOMICS:Toolbox Genomics is a data interpretation service. They take genetic data generated by a CLIA/CAPP certified lab and compare it against hundreds of genetic markers that our research team has identified as significant. The company also has a comprehensive data protection privacy policy, which you can find outlined on their website. ABOUT DR. ERIKA GRAY:Dr. Erika Gray, is a UCSF trained pharmacist, educator, national speaker and co-founder and Chief Medical Officer of ToolBox Genomics and MyToolBox Genomics, a digital platform that takes an individual's genetic test results and offers a virtual toolbox of informative, user-friendly, lifestyle choices and action plans to live the healthiest possible life. With almost 2 decades of experience in the world of functional medicine and a decade of experience in genomics and pharmacy, Dr. Gray is dedicated to helping practitioners and individuals understand the intersection of their unique genetics with the environment, and how they can positively change their health trajectory.ABOUT BEAUTY & THE BIOHACKER:Learn more: beautyandthebiohacker.comEmail us at info@beautyandthebiohacker.comABOUT RACHEL & KATIE:Learn more with Rachel Varga BScN, RN, CANS, Board Certified Aesthetic Nurse Specialist https://RachelVarga.caBOOK YOUR ONE ON ONE Virtual Skin and Aging Consultation with Rachel Varga here: https://RachelVarga.ca/get-startedLearn more with Katie Type A: https://katietypea.comCheck out Katie Type A's YouTube Channel: https://bit.ly/3le3MUJDISCLAIMER: Information in this podcast and interview is not to be taken as medical advice, and always consult with your Physician before making any lifestyle changes. The material shared by guests in this podcast is not the opinion of Rachel Varga or Katie Moore, and disclaims any responsibility of inaccurate credentials of guests or information used that may cause harm. Always consult with your licensed Physician before any lifestyle modifications.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
In this episode of the Epigenetics Podcast, we caught up with Tim Petros from the Eunice Kennedy Shriver National Institute of Child Health and Human Development at the NIH to talk about his work on Single Cell Epigenomics in Neuronal Development. The Petros lab focuses on “interneurons”, their diversity and how environmental signals interact to generate this diversity. This subgroup of neurons comprise about 20% of neutrons in the brain, however, they are the primary source of inhibition. Furthermore, interneurons are critical components in modulating information flow throughout the nervous system. The Petros lab seeks to uncover the genetic programs that lead to the incredible diversity in interneurons, as well as how the local environment influences this process. To lay a foundation for this and to provide a data-base for other researchers the Petros lab generated an epigenome atlas of neural progenitor cells of the mouse brain. This data includes scRNA-Seq, snATAC-Seq, CUT&Tag (H3K4me3, H3K27me3), CUT&RUN (H3K27ac), Hi-C and Capture-C. This data can be downloaded at the link below: https://www.nichd.nih.gov/research/atNICHD/Investigators/petros/data-sharing References Datasets: https://www.nichd.nih.gov/research/atNICHD/Investigators/petros/data-sharing Quattrocolo G, Fishell G, Petros TJ. Heterotopic Transplantations Reveal Environmental Influences on Interneuron Diversity and Maturation. Cell Rep. 2017 Oct 17;21(3):721-731. doi: 10.1016/j.celrep.2017.09.075. PMID: 29045839; PMCID: PMC5662128. Dongjin R Lee, Christopher Rhodes, Apratim Mitra, Yajun Zhang, Dragan Maric, Ryan K Dale, Timothy J Petros (2022) Transcriptional heterogeneity of ventricular zone cells in the ganglionic eminences of the mouse forebrain eLife 11:e71864 https://doi.org/10.7554/eLife.71864 Rhodes, C. T., Thompson, J. J., Mitra, A., Asokumar, D., Lee, D. R., Lee, D. J., Zhang, Y., Jason, E., Dale, R. K., Rocha, P. P., & Petros, T. J. (2022). An epigenome atlas of neural progenitors within the embryonic mouse forebrain. Nature communications, 13(1), 4196. https://doi.org/10.1038/s41467-022-31793-4 Related Episodes The Role of Histone Dopaminylation and Serotinylation in Neuronal Plasticity (Ian Maze) Single-Cell Technologies using Microfluidics (Ben Hindson, CSO of 10x Genomics) The Role of DNA Methylation in Epilepsy (Katja Kobow) Contact Active Motif on Twitter Epigenetics Podcast on Twitter Active Motif on LinkedIn Active Motif on Facebook Email: podcast@activemotif.com
Welcome to the Siim Land Podcast I'm your host Siim Land and our guest today is Dr Kara Fitzgerald. Dr Kara is a naturopathic doctor and an author. She was one of the authors of a 2021 study that showed for the first-time biological age reversal in humans. She also has a book called Younger You. Timestamps 01:30 First Study Showing Age Reversal in Humans 06:28 Biological vs Chronological Age 08:45 DNA Methylation and Epigenetics 17:45 What Causes DNA Methylation Aging 24:30 Optimizing Methylation for Anti-Aging 33:40 The Diet for Age Reversal 43:30 Stress and Aging 49:10 How Long Can We Live 54:20 Dr Kara's Biological Age This episode is brought to you by BON CHARGE. My favorite light and sleep optimization company BluBlox has rebranded itself as BON CHARGE. They're now involved with a huge range of evidence-based products to improve your wellness and life in every way. Their extensive range of premium wellness products help you sleep better, perform better, have more energy, recover faster, balance hormones, and reduce inflammation…the list is endless. From blue light glasses to EMF management and circadian-friendly lighting, BON CHARGE products help you naturally address the issues of our modern-day way of life effortlessly and with maximum impact. My favorite products are the red light lightbulbs because they can be used to create a melatonin-friendly environment in your bedroom by shining only red and not blue or green lightwaves that would reduce your sleep quality. After using these red lightbulbs, I find it much easier to fall asleep and feel less awake before bed. Go to boncharge.com/SIIMLAND and use coupon code SIIM15 to save 15%. Here are the links to the podcast on all platforms Link to the Audio Podcast on iTunes and Stitcher Link to the podcast on Spotify Link to the podcast on CastBox Watch the Biohacking Bootcamp Videos on Patreon This episode is sponsored by BiOptimizers. They're giving the listeners of this podcast an exclusive offer on one of their best-selling products. It's called Magnesium Breakthrough and is the most full-spectrum magnesium supplement out there. Most supplements contain only 1 or 2 forms of magnesium... when in reality there are at least 7 that your body needs and benefits from. Magnesium is the master mineral that governs virtually all physiological processes in the body. With volume discounts combined with our custom 10% coupon code, SIIM10, you can save up to 40% off select packages of Magnesium Breakthrough! That's an AMAZING value. And I promise that deal is ONLY available on this specific website, Click Here to Support the Show on Patreon! Show Notes Code SIIM15 for 15% OFF BluBlox My NEW Book WIN on Amazon! Join Inside Tracker for 25% Off with Code SIIMLAND Lucas Aoun's Natural Testosterone Optimization Course 10% OFF The Immunity Fix on Amazon Get Magnesium Breakthrough for a 10% Discount! Use Code SIIM for 10% Off Self Decode Use Code SIIM for a 10% Discount on the KAATSU Bands My New Book Stronger by Stress My NEW BOOK Metabolic Autophagy Metabolic Autophagy Audiobook Metabolic Autophagy Master Class Total Sleep Optimization Video Course Get the FULL GUIDE to INTERMITTENT FASTING FREE BOOK Get the Metabolic Autophagy Program Keto Adaptation Manual Book Watch the Biohacking Bootcamp Videos on Patreon Body Mind Empowerment Handbook Keto Fit Program Keto // IF Program Stay Empowered Siim
Join Dr. Gladden on this conversation with Ryan Smith about epigenetic age testing and DNA methylation. Ryan has a biochemistry degree from the University of Transylvania. He went to medical school and started clinical rotations before realizing he didn't want to be a doctor. That's when he pivoted to the world of pharmacy, focusing on peptide synthesis, and opened up Tailor Made Compounding. Ryan has been very successful in his endeavors, with Tailor Made Compounding becoming the 4th fastest growing healthcare company at the time, investing in several other functional medicine spaces and, eventually, starting TruDiagnostic. This is a CLIA certified lab and health data company focused and committed to research with over 30 approved clinical research studies investigating the epigenetic methylation changes of a variety of longevity and health interventions. They have created one of the largest private epigenetic health databases in the world with over 13,000 patients tested and continue to lead the space in epigenetic methylation interpretation and diagnostic prediction. In this episode, him and Dr. Gladden discuss how epigenetic age testing and DNA methylation have evolved, the different kinds of clocks that exist now and what they measure, as well as the advances being made and envisioned in the disease prevention and age reversal spaces. Show notes: 00:55 Dr. Gladden gives a description of this episode and an introduction of Ryan Smith. 02:20 Dr. Gladden explains why he is excited for this show. 03:15 Ryan introduces the audience to TruAge and tells us the big takeaway from this testing. 04:50 What is epigenetic methylation? What are the two main epigenetic marks? Ryan explains our DNA's "on and off switches". 05:57 Dr. Gladden clarifies what is being measured exactly. 06:29 The concept of methylation clock is introduced by Dr. Gladden, and he explains how it keeps track of the aging process but also contributes to it. 07:11 Dr. Gladden asks if Ryan's company is measuring acetylation patterns as well. 07:17 Ryan talks about clinical trials where they are also measuring acetylation patterns and why it's proven not to be ready for prime time large-scale investigation. 08:20 Dr. Gladden asks if they're hitting a plateau in terms of accuracy with the amount of genes being tested. 09:02 Ryan explains why doubling the amount of genes being tested doesn't necessarily translate into a doubling of accuracy. 09:09 How are they getting an insight into the path of physiology? Ryan talks about seeing what is changing and why it is changing, why this is the best way to capture the aging process (which is the biggest risk factor for chronic disease and death) and what questions they are trying to answer. 09:59 Dr. Gladden asks if they are hitting a plateau in cost-effectiveness. 10:49 Dr. Gladden tells the audience why they should care about this and what sets TruDiagnostic apart from other methylation companies. They can predict disease and mortality. 13:44 Ryan talks about the evolution of these algorithms and what people can expect from the reports of their testing. 14:40 Second and third generation clocks are introduced during this intervention before tackling their reports individually. 17:15 Dr. Gladden talks about the benefits gained from these reports/testing. 18:55 What can people do to impact their methylation? Ryan elaborates on the different types of interventions, from lifestyle changes to clinical interventions. 23:19 Dr. Gladden introduces very small embryonic-like stem cells and talks about how there's data being recorded in some trials where these are moving the epigenetic age even 3 or 4 years back in time. 25:30 Ryan talks about what he's seeing with plasma and plasmapheresis interventions. Explains why the results they're seeing are giving them so much hope that these therapies might be one of the ways to reverse the clock. 29:30 Dr. Gladden explains why they can't look at one data point and say that's the answer in this field. 29:58 They introduce the DunedinPace algorithm for rate of aging, which is the first ever third generation algorithm. Ryan explains why it's one of their favorites and how it is making things clearer and giving one of the best metrics they can offer. 35:00 Dr. Gladden talks about what they don't have dialed in yet with these therapies. 35:19 Ryan describes how they're trying to bridge the gap by providing answers to those "how long" questions with their data sets. 36:20 Will the system spring back to its natural age? Or will we be able to reset it? Dr. Gladden poses the question based on the concept of transient epigenetic aging. 36:58 Ryan talks about what he thinks is probably the most exciting area of age reversal right now. 38:49 Dr. Gladden asks Ryan how people can reasonably compare between companies doing this kind of testing and choose their best option. 40:40 Ryan explains the different tissues that can be used for testing and how that's going to affect the algorithm's results. 41:55 Ryan explains the importance of these algorithms' (clocks') precision. 43:20 Dr. Gladden talks about his experience with methylation ages in urine and how he uses it as a screening test. 44:53 Dr. Gladden introduces the GrimAge algorithm, which predicts when someone is going to die. 45:49 Ryan elaborates on the GrimAge algorithm's excellence and explains how it is the most accurate and most predictive. 49:43 Dr. Gladden explains what methylation measurements are actually doing and what they mean for the audience. 51:16 Dr. Gladden asks Ryan his top 3 pieces of advice to optimize your longevity, health and human performance. Visit our website, www.gladdenlongevitypodcast.com, for more information on this episode and other episodes as well. Follow us on social media! Instagram: @gladdenlongevitypodcast Twitter: @GLPodcast_ Facebook: @GladdenLongevityPodcast https://twitter.com/TruDiagnostic https://www.instagram.com/trudiagnosticofficial/ https://www.youtube.com/channel/UC408EGTLhAf8haqe1H5Ep_Q https://www.facebook.com/TruDiagnostic/ https://www.linkedin.com/company/trudiagnostic/
John R. Miles - The Reverse Aging Effect: How to Stay Young and Healthy | Brought to you by AppSumo (https://social.appsumo.com/passion) and Gusto (https://www.gusto.com/passionstruck.) New research indicates that Ponce de Leon's much-hoped-for Fountain of Youth may be closer to reality than we imagined. And, that, my friends, is no science fiction. However, You don't have to imagine or hope for a mythical fountain of youth that holds the secret of reverse aging. You can decide daily to turn back the clock, slow the aging process, and reset your age. --► Full show notes: https://passionstruck.com/the-reverse-aging-effect-stay-young-and-healthy/ --► Subscribe to My YouTube Channel Here: https://www.youtube.com/c/JohnRMiles --► Subscribe to the podcast: https://podcasts.apple.com/us/podcast/passion-struck-with-john-r-miles/id1553279283. *Our Patreon Page: https://www.patreon.com/passionstruck. Thank you for listening to this podcast. I hope you keep up with the weekly videos I post on the YouTube channel, subscribe to, and share your learnings with those who need to hear them. Your comments are my oxygen, so please take a second and say 'Hey' ;). Thank You To Our Sponsors: More Info At PassionStruck.Com/Deals Thank You, Gusto For Sponsoring. Gusto offers all-in-one payroll and HR for growing businesses. From full-service payroll and benefits to team management tools, Gusto makes it easy to support your hardworking team in one intuitive platform. Gusto is offering our listeners three months free: https://www.gusto.com/passionstruck. Thank You AppSumo For Sponsoring. Over 1 million entrepreneurs and creators trust AppSumo to help them discover, buy, and sell the products they need to grow their business and audience. As a special bonus, AppSumo is giving 10% off the already discounted price to the first 100 people who click the link in the show notes: https://social.appsumo.com/passion. Passion Struck Podcast Starter Packs New to the show? These Starter Packs are collections of our most popular episodes grouped by topic, and we now have them also on Spotify. You can also browse starter packs for existing listeners to find your old favorites. Every week, John interviews everyday heroes from all walks of life. Learn how to subscribe to the show and never miss a new episode and topic. What I discuss about the reverse aging effect: In this episode, I will discuss how we can intentionally slow down our biological aging process. Yes, you heard that right. Finding the core reason for aging and learning how diet, lifestyle choices, and exercise affect extending your life places the power of perspective and knowledge within your control. 0:00 Introduction and announcements 3:02 The quest for the fountain of youth 5:23 Why biological aging is influenced by our behavior 10:13 The science behind reverse aging 13:24 How Epigenetics and DNA Methylation impact reverse aging 16:16 Six secrets to reverse aging 23:04 Our future health is in our own hands 25:11 Analysis and future guest promo Show Links Show discussion questions: What is the history of the search for the fountain of youth? Why is reverse aging a hard topic for people to grasp? What were the key results of Ellen Langer's experience with the older men? What is the difference between chronological age and biological age? What other research has Dr. David Sinclair been involved with? What are your takeaways on epigenetics? How can you apply the six ways to reverse aging? What three things can you do to alter how you approach aging? What steps will you take after hearing today's episode to change your approach to how you are approaching your aging process? Interested in reading the transcript for the episode: https://johnrmiles.com/the-reverse-aging-effect-how-to-live-longer/ Lifespan: Why We Age and Why We Don't Have to By David Sinclair Ph.D.: https://amzn.to/3a1aaP7 Younger You: Reduce Your Bio Age And Live Longer, Better by Dr. Kara Firzgerald: https://amzn.to/3AgDYlf My episode on why you should Why the Journey Is More Important Than the Destination: https://passionstruck.com/life-is-about-the-journey-not-the-destination/ My interview with Katy Milkman Ph.D. on how to create lasting behavior change: https://passionstruck.com/katy-milkman-behavior-change-for-good/ My interview with David Yaden Ph.D. on Self-Transcendence, Psychedelics, and Behavior Change: https://passionstruck.com/david-yaden-on-self-transcendence-experiences/ My interview with Elise Micheals on How Men Can Take Back their Power: https://passionstruck.com/elise-micheals-the-power-of-being-a-man/ My interview with Cathy Heller on How Do You Find Your Life's Passion: https://passionstruck.com/cathy-heller-how-do-you-find-your-lifes-passion/ Are you having trouble prioritizing yourself? I discuss the importance of self-love in Episode 104 Follow John on the Socials: * Twitter: https://twitter.com/Milesjohnr * Facebook: https://www.facebook.com/johnrmiles.c0m * Medium: https://medium.com/@JohnRMiles * Instagram: https://www.instagram.com/john_r_miles * LinkedIn: https://www.linkedin.com/in/milesjohn/ * Blog: https://johnrmiles.com * Instagram: https://www.instagram.com/passion_struck_podcast/ * Gear: https://www.zazzle.com/store/passion_struck/ -- John R Miles is a serial entrepreneur and the CEO and founder of Passion Struck. His full-service media company helps people live intentionally by creating best-in-class educational and entertainment content. John is also a prolific public speaker, venture capitalist, and author named to the ComputerWorld Top 100 IT Leaders.
In this episode of the Epigenetics Podcast, we caught up with Jan Żylicz from the Novo Nordisk Foundation Center for Stem Cell Medicine to talk about his work on epigenetic and metabolic regulation of early development. The focus of the Żylicz Lab is studying early development and how this process is influenced by epigenetic factors. In more detail, the Team focuses on the function of chromatin modifiers in this process. Primed pluripotent epiblasts in vivo show a distinct chromatin landscape that is characterized by high levels of histone H3 lysine 9 dimethylation (H3K9me2) and rearranged Polycomb-associated histone H3 lysine 27 trimethylation (H3K27me3) at thousands of genes along the genome. However, the function of only about 100 loci is impaired. The Żylicz Lab tries to understand this process behind and also the cause of this discrepancy. References Żylicz, J. J., Bousard, A., Žumer, K., Dossin, F., Mohammad, E., da Rocha, S. T., Schwalb, B., Syx, L., Dingli, F., Loew, D., Cramer, P., & Heard, E. (2019). The Implication of Early Chromatin Changes in X Chromosome Inactivation. Cell, 176(1–2), 182-197.e23. https://doi.org/10.1016/j.cell.2018.11.041 Dossin, F., Pinheiro, I., Żylicz, J. J., Roensch, J., Collombet, S., Le Saux, A., Chelmicki, T., Attia, M., Kapoor, V., Zhan, Y., Dingli, F., Loew, D., Mercher, T., Dekker, J., & Heard, E. (2020). SPEN integrates transcriptional and epigenetic control of X-inactivation. Nature, 578(7795), 455–460. https://doi.org/10.1038/s41586-020-1974-9 Related Episodes Epigenetics and X-Inactivation (Edith Heard) The Effects of Early Life Stress on Mammalian Development (Catherine J. Peña) DNA Methylation and Mammalian Development (Déborah Bourc'his) Contact Active Motif on Twitter Epigenetics Podcast on Twitter Active Motif on LinkedIn Active Motif on Facebook Email: podcast@activemotif.com
Dr. Kara Fitzgerald breaks down the science of DNA methylation and how we can actually reverse our age. We discuss her new book Younger You: Reduce Your Bio Age And Live Longer, Better. Her book has been highly praised by all the big players in our biohacking space like Dr. Dale Bredesen, Dr. Mark Hyman and Dr. Sara Gottfried. I loved reading it and can highly recommend you to read it too. We scratch the surface of some of the topics of her book, but if you want the deep dive, just go get it here. Dr. Fitzgerald is a Naturopathic Doctor and a functional medicine doctor certified with the IFM's Functional Medicine Certification Program. She is the first-ever recipient of the 2018 Emerging Leadership Award from the Personalized Lifestyle Medicine Institute in recognition of her work on DNA methylation. Dr. Fitzgerald is well known in the wellness circles and is a leading voice in nutrition, epigenetics, and aging. You probably already come across some of her work in the media such as in Prevention, Fast Company, MSN, Everyday Health, and many more. She got her doctorate from National University of Natural Medicine, she is on the faculty at the Institute for Functional Medicine (IFM) and is an IFM Certified Practitioner with a clinical practice in Newtown, Connecticut. So, if you are looking for a functional medicine doctor in that area, she's got your back. CONTACT DR. FITZGERALD: Website: https://www.drkarafitzgerald.com/ Facebook: https://www.facebook.com/DrKaraFitzgerald/ Instagram: https://www.instagram.com/drkarafitzgerald// Twitter: https://twitter.com/kfitzgeraldnd YouTube: https://www.youtube.com/c/Drkarafitzgerald Podcast: https://www.drkarafitzgerald.com/fxmed-podcast/ Join the Hack My Age community on: Facebook Page : http://facebook.com/hackmyage Facebook Group: Biohacking Women 50+ - Longevity After Menopause https://www.facebook.com/groups/biohackingwomen50 Instagram: http://instagram.com/hackmyage Website: http://www.hackmyage.com Clubhouse: @hackmyage (Club: Biohacking Women 50+) Hack My Age VIP Group: http://patreon.com/hackmyage Email: zora@hackmyage.com Newsletter: http://www.hackmyage.com/newsletter This podcast is edited by jonathanjk.com --- Send in a voice message: https://anchor.fm/hackmyage/message Support this podcast: https://anchor.fm/hackmyage/support
In this episode of the Epigenetics Podcast, we caught up with Ian Maze from Ichan School of Medicine at Mount Sinai and a Howard Hughes Medical Institute (HHMI) Investigator to talk about his work on the role of histone dopaminylation and serotinylation in neuronal plasticity. The Maze group focuses on understanding the complex interplay between chromatin regulatory mechanisms in brain and neuronal plasticity. The lab places an emphasis on psychiatric disorders associated with monoaminergic (e.g., serotonin, dopamine, etc.) dysfunction, such as major depressive disorder and drug addiction. In particular the Maze team has investigated cocaine addiction and its effect on chromatin by serotonylation and dopaminylation of Histone H3 Tails. References Maze, I., Covington, H. E., Dietz, D. M., LaPlant, Q., Renthal, W., Russo, S. J., Mechanic, M., Mouzon, E., Neve, R. L., Haggarty, S. J., Ren, Y., Sampath, S. C., Hurd, Y. L., Greengard, P., Tarakhovsky, A., Schaefer, A., & Nestler, E. J. (2010). Essential Role of the Histone Methyltransferase G9a in Cocaine-Induced Plasticity. Science, 327(5962), 213–216. https://doi.org/10.1126/science.1179438 Farrelly, L. A., Thompson, R. E., Zhao, S., Lepack, A. E., Lyu, Y., Bhanu, N. V., Zhang, B., Loh, Y.-H. E., Ramakrishnan, A., Vadodaria, K. C., Heard, K. J., Erikson, G., Nakadai, T., Bastle, R. M., Lukasak, B. J., Zebroski, H., Alenina, N., Bader, M., Berton, O., … Maze, I. (2019). Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3. Nature, 567(7749), 535–539. https://doi.org/10.1038/s41586-019-1024-7 Lepack, A. E., Werner, C. T., Stewart, A. F., Fulton, S. L., Zhong, P., Farrelly, L. A., Smith, A. C. W., Ramakrishnan, A., Lyu, Y., Bastle, R. M., Martin, J. A., Mitra, S., O'Connor, R. M., Wang, Z.-J., Molina, H., Turecki, G., Shen, L., Yan, Z., Calipari, E. S., … Maze, I. (2020). Dopaminylation of histone H3 in ventral tegmental area regulates cocaine seeking. Science, 368(6487), 197–201. https://doi.org/10.1126/science.aaw8806 Related Episodes Development of Integrative Machine Learning Tools for Neurodegenerative Diseases (Enrico Glaab) Epigenetic Influence on Memory Formation and Inheritance (Isabelle Mansuy) CpG Islands, DNA Methylation, and Disease (Sir Adrian Bird) Contact Active Motif on Twitter Epigenetics Podcast on Twitter Active Motif on LinkedIn Active Motif on Facebook Email: podcast@activemotif.com
Kara Fitzgerald, ND, IFMCP, is the first-ever recipient of the Emerging Leadership Award from the Personalized Lifestyle Medicine Institute in recognition of her work on DNA methylation. As a leading voice in the intersection of nutrition, epigenetics, and aging, Dr. Fitzgerald's work has been featured in media outlets such as Prevention, Fast Company, MSN, Everyday Health, and many more. Receiving her doctorate from National University of Natural Medicine, she is on the faculty at the Institute for Functional Medicine (IFM) and is an IFM Certified Practitioner with a clinical practice in Newtown, Connecticut. Learn more at https://youngeryouprogram.com/ and www.KaraFitzgerald.com. In today's episode, Dr. Fitzgerald teaches all things DNA Methylation and its relationship with aging. We discuss how it is impacted by our nutrition, exercise, stress and other factors, and how to reduce our biological age. Instagram: @drkarafitzgerald Younger You: https://amzn.to/37H9M6G Website: https://www.drkarafitzgerald.com/ For 15% off your Clearly Filtered Order: Use the code JUSTINGREDIENTS at https://www.clearlyfiltered.com/?rfsn=4850831.504d9f5
Welcome to the Siim Land Podcast, I'm your host Siim Land and today our guest is Dr. Brad Stanfield. Brad is a medical doctor from New Zealand. He also makes YouTube videos about extending healthspan and longevity. This episode is brought to you by BluBlox – my favorite light and sleep optimization company. Artificial light at night exposure at night is associated with diabetes, obesity, heart disease, cancer, and Alzheimer's. BluBlox provides the highest quality blue-blocking glasses that filter out the specific wavelengths that have been shown to suppress melatonin in studies. Melatonin is more than the sleep hormone. It's also vital for longevity, anti-aging and immunity. Artificial light exposure suppresses melatonin up to 99% and makes your brain think it's daytime before bed. That's why I love using my BluBlox blue blockers to guarantee my body is making a high amount of melatonin prior to sleep. They also have daytime lenses that you can use to reduce digital eye strain and retinal damage when working in front of a computer all day. You can get a sweet 15% discount off all the BluBlox glasses, red light bulbs, red light devices, and sleep masks if you head over to blublox.com/siimland and use the code SIIM15. That's BLUBLOX.com/SIIMLAND and the code is SIIM15. Timestamps: 01:45 Why Dr Brad Started Making Videos 04:30 Does Your Metabolic Rate Decrease with Age 07:00 DNA Methylation and Biological Age 10:05 Extending Healthspan Starter Pack 13:40 Healthspan vs Lifespan 16:46 Intermittent Fasting and Calorie Restriction 22:00 High Protein vs Low Protein Diet 26:00 Longevity Supplement Starter Pack 30:30 Brad's Favorite Longevity Supplements 36:20 Do NAD Boosters Work for Lifespan 39:18 Which NAD Booster Is Most Effective 43:00 Are Sirtuins Longevity Genes 50:15 Is Alpha Keto-Glutarate Beneficial 54:25 What Supplements Brad Takes And much more Here are the links to the podcast on all platforms Link to the Audio Podcast on iTunes and Stitcher Link to the podcast on Spotify Link to the podcast on CastBox Watch the Biohacking Bootcamp Videos on Patreon This episode is sponsored by BiOptimizers. They're giving the listeners of this podcast an exclusive offer on one of their best-selling products. It's called Magnesium Breakthrough and is the most full-spectrum magnesium supplement out there. Most supplements contain only 1 or 2 forms of magnesium... when in reality there are at least 7 that your body needs and benefits from. Magnesium is the master mineral that governs virtually all physiological processes in the body. With volume discounts combined with our custom 10% coupon code, SIIM10, you can save up to 40% off select packages of Magnesium Breakthrough! That's an AMAZING value. And I promise that deal is ONLY available on this specific website, Click Here to Support the Show on Patreon! Show Notes Code SIIM15 for 15% OFF BluBlox My NEW Book WIN on Amazon! Join Inside Tracker for 25% Off with Code SIIMLAND Lucas Aoun's Natural Testosterone Optimization Course 10% OFF The Immunity Fix on Amazon Get Magnesium Breakthrough for a 10% Discount! Use Code SIIM for 10% Off Self Decode Use Code SIIM for a 10% Discount on the KAATSU Bands My New Book Stronger by Stress My NEW BOOK Metabolic Autophagy Metabolic Autophagy Audiobook Metabolic Autophagy Master Class Total Sleep Optimization Video Course Get the FULL GUIDE to INTERMITTENT FASTING FREE BOOK Get the Metabolic Autophagy Program Keto Adaptation Manual Book Watch the Biohacking Bootcamp Videos on Patreon Body Mind Empowerment Handbook Keto Fit Program Keto // IF Program Stay Empowered Siim
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