Podcasts about optic

A moment of silence for Derek Chauvin was a really bad optic by the state GOP. Missing or dead scientist connected to UFO research are beginning to be found. Teen campers in Idaho spent Memorial Day weekend with Bigfoot. Joe and Kenny get into a big Trump fight and will settle it during the undercard of the UFC match at the White House. Johnny Heidt with guitar news. Heard On The Show:Lisa Demuth to continue bid for Minnesota governor at Republican primary after convention chaosFrey picks 30-year MPD vet as interim police chief week after O'Hara resignedTrump names Bill Pulte acting director of national intelligenceSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

OpTic Gaming Merch: https://shop.opticgaming.com/Check out the OpTic SCUF collection and use code “OpTic” for a discount: https://scuf.co/OpTicCheck out the OpTic Podcast here: https://podcasts.apple.com/us/podcast/optic-podcast/id1542810047https://open.spotify.com/show/25iPKftrl0akOZKqS0wHQG

The boys predict CDL Minor 2, break down OpTic's 6-0 flawless weekend, Paris Gentle Mates drama with Sib vs Exceed, and rank the worst Call of Duty teams we have ever seen.

Go to http://rocketmoney.com/optic to reach your financial goals faster. New users get $50 when they play their first $5 lineup on https://www.prizepicks.com using code: OpTic OpTic Gaming Merch: https://shop.opticgaming.com/ Check out the OpTic SCUF collection and use code “OpTic” for a discount: https://scuf.co/OpTic Check out the OpTic Podcast here: https://podcasts.apple.com/us/podcast/optic-podcast/id1542810047 https://open.spotify.com/show/25iPKftrl0akOZKqS0wHQG Why the Cloud 9/Bush Drama Isn't Good for COD | The OpTic Podcast Ep. 278 00:00 - Intro 00:26 - Drake and LeBron Join the Pod!! 03:12 - Surge Drop TJHaly 04:20 - MaNiaC Has a GF?? 07:52 - Cloud 9 vs. Bush 20:48 - Most Expensive Buyout in COD History 22:40 - More C9 vs. Bush 26:48 - Gentle Mates Trade Envoy 28:02 - Standy Joins Ravens, Craze Dropped 29:20 - Gwinn Dropped from Surge 30:42 - Nastie Leaving Breach?? 32:15 - Prize Picks 33:48 - Rocket Money 35:41 - Rostermania Recap 37:11 - NEW CDL Maps! 38:11 - How OpTic Can Bounce Back in Stage 4 42:46 - Dashy's 1v2 Quick Scope 45:51 - Huntsmen Update (Swooty/Owakening) 53:06 - AT&T Annihilator Cup Recap 59:06 - Happy GTA 6 Release Day! 01:00:11 - Renegade Qualifies for Halo LAN 01:02:02 - The Most Expensive Pizza EVER 01:03:08 - Kai Cenat/AMP Returning? 01:05:03 - Do We Take iPhones For Granted? 01:05:52 - New Ferrari Reveal 01:06:55 - Jay and Fatty Need Help Learn more about your ad choices. Visit megaphone.fm/adchoices

OpTic Gaming Merch: https://shop.opticgaming.com/Check out the OpTic SCUF collection and use code “OpTic” for a discount: https://scuf.co/OpTicCheck out the OpTic Podcast here: https://podcasts.apple.com/us/podcast/optic-podcast/id1542810047https://open.spotify.com/show/25iPKftrl0akOZKqS0wHQG00:00 Intro01:00 Iceman Review Part 207:00 Pamaj Banned 33:00 Pamaj brought questions 40:00 New music vs old music 43:00 What are the skips? 48:00 Eras of Rap

OpTic Gaming Merch: https://shop.opticgaming.com/Check out the OpTic SCUF collection and use code “OpTic” for a discount: https://scuf.co/OpTicCheck out the OpTic Podcast here: https://podcasts.apple.com/us/podcast/optic-podcast/id1542810047https://open.spotify.com/show/25iPKftrl0akOZKqS0wHQG

Episode: 3298 Gender, Color, and Dichotomy in Tennis.  Today, we take sides in tennis.

OpTic Gaming Merch: https://shop.opticgaming.com/Check out the OpTic SCUF collection and use code “OpTic” for a discount: https://scuf.co/OpTicCheck out the OpTic Podcast here: https://podcasts.apple.com/us/podcast/optic-podcast/id1542810047https://open.spotify.com/show/25iPKftrl0akOZKqS0wHQGThe Iceman Album Review | The Flycast Ep. 191

Invincible VS is out now on PlayStation, Xbox, and PC. Full Leaderboard, Rules, Competitors, and more info on the AT&T Annihilator Cup can be found at https://att.com/annihilatorcup OpTic Gaming Merch: https://shop.opticgaming.com/ Check out the OpTic SCUF collection and use code “OpTic” for a discount: https://scuf.co/OpTic Check out the OpTic Podcast here: https://podcasts.apple.com/us/podcast/optic-podcast/id1542810047 https://open.spotify.com/show/25iPKftrl0akOZKqS0wHQG 00:00 - Intro 02:06 - Huke Stung by a Wasp 05:03 - Major III Tournament Recap 06:07 - Which CDL Teams Need to Change? 23:13 - Esports Worlc Cup Moves to Paris 25:11 - Zin's Smell 26:11 - Brick by Brick, Can by Can 27:16 - Major III Mainstage Controversy 29:57 - Finals Format 32:56 - Invincible VS 35:14 - Dashy's Quick Scope 1v2 38:11 - Shout Out DreamHack Atlanta 42:52 - ATL Food 44:05 - OpTic vs LA Thieves Grand Final 49:09 - Jersey Jerry Went NUCLEAR 51:02 - AT&T Annihilator Cup Week 2 Recap 57:38 - The Next Donk?? 58:24 - He Hit Apex Masters on a Unicycle 59:37 - Amazon Launches AI-Hosted Podcasts 01:01:40 - INSANE BMX Trick 01:03:43 - WTF is Up Denny's Turns 13 01:04:51 - The Best Taco Experience in Dallas Learn more about your ad choices. Visit megaphone.fm/adchoices

Vines- I'll be Here a1 https://vinesmusic.bandcamp.com/album/ill-be-here c2- Cyber Monday b7 Green-House- Hinterlands a1 https://green-house.bandcamp.com/album/hinterlands Rival Consoles- Sonne b1 https://rivalconsoles.bandcamp.com/album/sonne Rod Modell- Frequencies in to Fog b1 https://silentes.bandcamp.com/album/frequencies-in-the-fog Black Dog- Music for Photographers a1 https://theblackdog.bandcamp.com/album/music-for-photographers KevinTheCreep- Marble Eternity a4 https://sicrecords.bandcamp.com/merch/kevinthecreep-marble-eternity-limited-edition-12-vinyl-record-10-copies Odd Nosdam- No More Wig for Ohio b6 https://nosdam.bandcamp.com/album/no-more-wig-for-ohio Dialect - Loose Blooms a2/3 https://densetruth.bandcamp.com/album/loose-blooms Lindsheaven Virtual Plaza- Transversal Worldwide Shopping b1https://lindsheavenvirtualplaza.bandcamp.com/album/transversal-worldwide-shopping Amulets- Rem(a)inders b1 https://amulets.bandcamp.com/album/rem-a-inders Pausal- Forms a2 https://pausal.bandcamp.com/album/forms Dirty Art Club- The Silver Suite b5 https://soundcloud.com/dirtyartclubofficial/sets/the-silver-suite-1 Clams Casino- Rainforest EP a1 https://clamscasinoofficial.bandcamp.com/album/rainforest Frog Concert- Slumbering Sounds of the Frog Fellowship II a5 https://frogconcert.bandcamp.com/album/slumbering-sounds-of-the-frog-fellowship-ii Anders Brorby- Kaiju b4 https://timereleasedsound.bandcamp.com/album/kaiju Funkmammoth- Retirement Resort b4 https://funkmammoth.bandcamp.com/album/retirement-resort O Yuki Conjugate- Slim Westerns I & II (TP) d5 https://asgt.bandcamp.com/album/slim-westerns-vol-ii    Optic Echo Presents  Tue 6-8pm PST  107.1 / 91.1 FM PDX  www.xray.fm

On the 236th episode of the Ego Chall Podcast, Justin Binkowski and Preston Byers discuss Call of Duty League (CDL) Major 3, including the Los Angeles Thieves' championship win, another OpTic Texas grand finals loss, Atlanta FaZe and the Paris Gentle Mates bowing out earlier, Toronto KOI's run, and much more.

The boys are back for CDL Major 3 in Atlanta, OpTic Texas fall short to the Los Angeles Thieves in the grand finals, CDL rostermania is back in session. The BUSH join the show to discuss their Major 3 masterclass.

FaZe ZooMaa, Benj, Parasite, Attach, Aches, and Octane break down the Call of Duty League Major 3 Day 2 matches from 5/16/2026

Welcome to the NeurologyLive® Mind Moments® podcast. Tune in to hear leaders in neurology sound off on topics that impact your clinical practice.In this Mind Moments episode, Scott Grossman, MD, assistant professor of neurology and ophthalmology at NYU Grossman School of Medicine, discusses emerging research on inter-eye retinal nerve fiber layer (RNFL) asymmetry as a biomarker of prior optic neuritis in pediatric-onset multiple sclerosis (POMS). Drawing from data presented at the 2026 American Academy of Neurology Annual Meeting, Grossman explains how optical coherence tomography (OCT) may help improve diagnostic confidence in pediatric MS by identifying remote optic nerve injury, while also outlining how a 4-micron inter-eye RNFL difference emerged as the optimal threshold in this cohort. The conversation also explores the role of OCT within the updated 2024 McDonald Criteria, the feasibility of integrating OCT into routine neurology practice, challenges surrounding normative pediatric OCT data, and future research directions involving visible light OCT and broader population datasets. Looking for more Multiple Sclerosis discussion? Check out the NeurologyLive® Multiple Sclerosis clinical focus page.Episode Breakdown: 1:15 – Optic nerve involvement and updated MS diagnostic criteria  3:20 – Pediatric RNFL asymmetry thresholds and interpretation of study findings 5:15 – Clinical implications of OCT biomarkers in pediatric-onset MS  6:40 – Neurology News Network  8:40 – Feasibility of incorporating OCT into neurology and MS practice  10:15 – Future research directions, including normative data and visible light OCT The stories featured in this week's Neurology News Minute, which will give you quick updates on the following developments in neurology, are further detailed here: FDA Approves AXS-05 as New Treatment for Alzheimer Disease Agitation FDA Approves Ocrelizumab for Pediatric Patients With Relapsing-Remitting Multiple Sclerosis Efgartigimod Gains FDA Approval as First Treatment for Seronegative Forms of Myasthenia Gravis Thanks for listening to the NeurologyLive® Mind Moments® podcast. To support the show, be sure to rate, review, and subscribe wherever you listen to podcasts. For more neurology news and expert-driven content, visit neurologylive.com.

This show is sponsored by BetterHelp. Sign up and get 10% off at http://BetterHelp.com/optic Invincible VS is out now on PlayStation, Xbox, and PC. New users get $50 when they play their first $5 lineup on https://www.prizepicks.com using code: OpTic Full Leaderboard, Rules, Competitors, and more info on the AT&T Annihilator Cup can be found at https://att.com/annihilatorcup OpTic Gaming Merch: https://shop.opticgaming.com/ Check out the OpTic SCUF collection and use code “OpTic” for a discount: https://scuf.co/OpTic Check out the OpTic Podcast here: https://podcasts.apple.com/us/podcast/optic-podcast/id1542810047 https://open.spotify.com/show/25iPKftrl0akOZKqS0wHQG 00:00 - Intro 00:59 - FormaL's Move 01:49 - Casey Neistat + Scump Hates Camping 05:39 - Ice Fishing 08:10 - OpTic x Huntsmen Pro-Am Major 3 18:50 - DreamHack Atlanta 21:36 - Hantavirus 26:46 - Methodz's CDL Record Survives 29:12 - P7 vs Bush INSANE Ending 32:50 - Prize Picks 35:03 - Better Help 36:43 - Invincible VS 38:42- 13-1'd by Lightning McQueen 39:53 - HOW Was This 21 Years Ago?? 41:56 - AT&T Annihilator Cup Week 1 Recap 51:01 - Scump Still Won't Go to Faker 51:57 - AT&T Annihilator Cup Week 2 56:17 - CouRage is Engaged! 57:36 - Did We Take This for Granted? (Nostalgia Bait) 01:00:48 - ChilledChaos Retires 01:02:17 - Gaming Reddit Read (Insp. by SmoshPit) Learn more about your ad choices. Visit megaphone.fm/adchoices

OpTic Gaming Merch: https://shop.opticgaming.com/Check out the OpTic SCUF collection and use code “OpTic” for a discount: https://scuf.co/OpTicCheck out the OpTic Podcast here: https://podcasts.apple.com/us/podcast/optic-podcast/id1542810047https://open.spotify.com/show/25iPKftrl0akOZKqS0wHQG00:00 Intro01:00 Drake Blackface 05:20 Everything wrong w/ the Internet 17:00 Pranks on the internet 23:00 ATB Guests & Cults 44:00 Lacy Arrested 49:20 Iceman Album

Urmărește podcastul numărul 279 de la Acasă la Măruță, unde Cătălin Măruță îl are ca invitat pe Romica Romașcu.#catalinmaruta #podcast #RomicaRomașcu

The boys are joined by OpTic Huke to preview CDL Major 3 in Atlanta, with four amateur teams joining the pros in the bracket. Worst 10 player tier list concludes the show (burger list).

FaZe ZooMaa, Benj, Parasite, and Rambo break down the Call of Duty League matches from 5/9/2026

Head to http://Factormeals.com/optic50off and use code optic50off to get 50% off and free daily greens per box Go to http://rocketmoney.com/optic to reach your financial goals faster. New users get $50 when they play their first $5 lineup on https://www.prizepicks.com using code: OpTic OpTic Gaming Merch: https://shop.opticgaming.com/ Check out the OpTic SCUF collection and use code “OpTic” for a discount: https://scuf.co/OpTic Check out the OpTic Podcast here: https://podcasts.apple.com/us/podcast/optic-podcast/id1542810047 https://open.spotify.com/show/25iPKftrl0akOZKqS0wHQG 00:00 - Intro 00:44 - Pranking Scump 03:08 - Intro (For Real This Time) 03:49 - Swooty's Initiation 05:05 - Straight Edge Type Swoot 09:39 - Getting to Know Swooty 12:32 - Scump's TROLLY CDL Intro Shoot 14:25 - More About Swooty 16:42 - Huntsmen Update 21:31 - Majormaniak 22:23 - Bush's New Team 23:54 - Swooty Will Do ANYTHING For OpTic 24:30 - Thanking Subs MID SERIES?! 26:22 - Swooty's INSANE Order 28:39 - Zinni Ego'd Swoot 30:08 - Prize Picks 33:07 - Factor 34:38 - Rocket Money 36:26 - Silky LOVES OpTic and Merc 40:02 - Geoff Keighley's Dad and Christopher Nolan 43:59 - Call of Duty Movie 46:02 - COD Campaigns 49:05 - Hacking and Gaming 55:05 - Chat GPT Gets Obsessed With Goblins 56:12 - Crime YouTube Channel Solves Cold Case 57:35 - NEW OpTic YouTube Series 58:49 - Ultimate 1/1 Draft Learn more about your ad choices. Visit megaphone.fm/adchoices

The boys break down another HUGE week of CDL action, with OpTic Texas finishing 2-0, BenJ beefing with FaZe Abuzah, and rostermania changes coming soon!

FaZe ZooMaa, Attach, Parasite, Octane, and Enable break down the Call of Duty League matches from 5/2/2026!

Dr. Beckett addresses questions about unsolicited autograph requests, arguing he won't respond without a real connection, and shares his view on collecting mascot/voice-talent autographs based on recognizability. He recalls Dallas's Shortstop card shop near SMU in the late 1980s, and comments on a nine-year extension for Connor Griffin as smart, with room to renegotiate if performance warrants. Beckett reviews recent openings: Panini Donruss Soccer Road to the FIFA World Cup (high card count, Optic seeding, autograph/memorabilia, a Christian Romero auto mistaken for Ronaldo) and Upper Deck releases including 2025-26 Flair hockey, 2026 AEW Allure and Allure Golf, and 2025-26 Metal Universe hockey highlighting PMGs, base-set appeal, and insert scarcity, then closes with playoff hockey and Stars fandom.   00:39 Autograph Request Policy 01:32 Mascot and Celebrity Autos 02:10 Dallas Card Shop Memories 03:09 Connor Griffin Contract Talk 04:02 Panini Donruss Soccer Rip 05:42 Upper Deck Flair Hockey 07:20 Allure Wrestling and Golf 09:46 Monopolies and Licenses 11:05 Metal Universe Hockey PMGs    

Welcome to the latest episode (May 2026) of Diabetes Core Update, where every month Neil Skolnik, MD and John Russell, MD review the most important articles on diabetes, obesity, and cardiometabolic disease. This month, they discuss: Marston NA, Bohula EA, Bhatia AK, et al. "Evolocumab to Reduce First Major Cardiovascular Events in Patients Without Known Significant Atherosclerosis and With Diabetes: Results From the VESALIUS-CV Trial." JAMA. 2026;335(16):1400–1407. doi:10.1001/jama.2026.3277 Lee YJ, Lee SJ, Kim JW, et al. "Intensive LDL Cholesterol Targeting in Atherosclerotic Cardiovascular Disease." N Engl J Med 2026;394:1365-1375. doi:10.1056/NEJMoa2600283 Nissen SE, Wolski K, D'Alessio D, et al. "Cardiorenal Outcomes With Tirzepatide Compared With Dulaglutide in Patients With Diabetes and Cardiovascular Disease: A Post Hoc Analysis of the SURPASS-CVOT Randomized Clinical Trial." JAMA Cardiol. Published online March 28, 2026. doi:10.1001/jamacardio.2026.0767 Moura FA, et al. "Association Between GLP-1 Receptor Agonists and Ischemic Optic Neuropathy: A Meta-analysis." Diabetes Care. 2026;49(5):724–729. doi.org/10.2337/dc25-1238 Ostrominski JW, Ortega-Montiel J, et al. "Comparative Effectiveness of Tirzepatide Versus Dulaglutide or Semaglutide on Major Cardiovascular Events in Type 2 Diabetes and Cardiovascular Disease: Insights From Two Target-Trial Emulations." Diabetes Care. 2026;49(5):808–817 doi.org/10.2337/dc25-3063 Nicole Napoli, "Shingles Vaccine Drastically Cuts Risk of Serious Cardiac Events." The American College of Cardiology. March 17, 2026 https://www.acc.org/About-ACC/Press-Releases/2026/03/16/19/33/Shingles-Vaccine-Drastically-Cuts-Risk-of-Serious-Cardiac-Events For information about the American Diabetes Association's scholarly journals, visit diabetesjournals.org. For more about this podcast, visit About Diabetes Core Update.

You can pre-order Invincible VS now on PlayStation, Xbox, and PC. Available April 30th OpTic Gaming Merch: https://shop.opticgaming.com/ Check out the OpTic SCUF collection and use code “OpTic” for a discount: https://scuf.co/OpTic Check out the OpTic Podcast here: https://podcasts.apple.com/us/podcast/optic-podcast/id1542810047 https://open.spotify.com/show/25iPKftrl0akOZKqS0wHQG 00:00 - Intro 01:27 - Toosh Takes Over The Golf Channel 05:45 - Can Scump Golf? 08:44 - Why Toosh Stopped Streaming 10:31 - Tfue is Fishing Now?! 11:45 - Texas Hail Storms are Different 15:37 - OpTic Texas Place T4 at Minor 1 21:25 - Huntsmen Update 26:27 - Major III Atlanta/Champs Plans 29:51 - Invincible VS 32:05 - Fisher College BEATS T1 Counter Strike Org 33:57 - Halo Scrapped its BR Mode 35:52 - Marathon 38:14 - Scump Played the Objective?! 41:47 - XQC Reacts to OpTic 43:33 - Chat GPT Coaches Dashy 44:58 - Scump Clears His Name 48:13 - Largest Great White Ever Recorded 51:45 - Ultimate 1of1 Draft Learn more about your ad choices. Visit megaphone.fm/adchoices

OpTic Gaming Merch: https://shop.opticgaming.com/Check out the OpTic SCUF collection and use code “OpTic” for a discount: https://scuf.co/OpTicCheck out the OpTic Podcast here: https://podcasts.apple.com/us/podcast/optic-podcast/id1542810047https://open.spotify.com/show/25iPKftrl0akOZKqS0wHQG00:00 Intro 01:00 Panic Attacks 09:00 Having kids 16:00 Buying A Home is impossible 24:00 Moving downtown 33:00 Meeting women in 202649:00 Toosh on the Golf Channel

Although rare, recognizing NMOSD is crucial for improving patient outcomes through correct diagnostic and treatment approaches. Reports of atypical forms and increasing knowledge of clinical, imaging, and laboratory-specific features are fundamental for the accurate recognition of this condition. Research on targeted therapies and biomarkers measuring and predicting disease activity will improve NMOSD management. In this episode, Gordon Smith, MD, FAAN, speaks with Sara Mariotto, MD, PhD, coauthor of the article "Neuromyelitis Optica Spectrum Disorder" in the Continuum® April 2026 Multiple Sclerosis and Related Disorders issue. Dr. Smith is a Continuum® Audio interviewer and a professor and chair of neurology at Kenneth and Dianne Wright Distinguished Chair in Clinical and Translational Research at Virginia Commonwealth University in Richmond, Virginia. Dr. Mariotto is a neurologist in the Neurology Unit in the Department of Neurosciences, Biomedicine, and Movement Sciences at the University of Verona in Verona, Italy. Additional Resources Read the article: Neuromyelitis Optica Spectrum Disorder Subscribe to Continuum®: shop.lww.com/Continuum Earn CME (available only to AAN members): continpub.com/AudioCME Continuum® Aloud (verbatim audio-book style recordings of articles available only to Continuum® subscribers): continpub.com/Aloud More about the American Academy of Neurology: aan.com Social Media facebook.com/continuumcme @ContinuumAAN Host: @GordonSmithMD Full episode transcript available here Dr Smith: Neurology is an increasingly therapeutic specialty, and across many of our subspecialty areas, lots of new drugs are being approved. Are you interested in learning more about a historically disabling disorder for which we now have a spectrum of new therapies that, if used appropriately and promptly in the right clinical situation, promise to dramatically improve patient outcomes? If so, keep listening. My name's Dr Gordon Smith. Today I'll be talking with Dr Sara Mariotto about her article on neuromyelitis optica spectrum disorder or NMOSD, which she wrote with Dr Romain Marignier. This article appears in the April 2026 Continuum issue on multiple sclerosis.  Dr Jones: This is Dr Lyell Jones, Editor-in-Chief of Continuum. Thank you for listening to Continuum Audio. Be sure to visit the links in the episode notes for information about earning CME, subscribing to the journal, and exclusive access to interviews not featured on the podcast.  Dr Smith: This is Dr Gordon Smith. Today, I'm interviewing Dr Sara Mariotto about her article on neuromyelitis optica spectrum disorder or NMOSD, which she wrote with Dr Romain Marignier. This article appears in the April 2026 Continuum issue on multiple sclerosis. Sara, welcome to the podcast, and maybe you can start by introducing yourself to our audience.  Dr Mariotto: Yes. Thanks, Gordon. I'm Sara Mariotto. I'm a neurologist, and I work at the Neurology Unit, University of Verona, where I do both clinical diagnosis and research into neuroimmunology---so, in particular, autoimmune encephalitis, NMOSD, and MOGAD.  Dr Smith: Well, this is a super exciting area. Whenever I hear about NMOSD, I think of one specific patient I had, and I always think of her when I come across something like your article, which is really fantastic. So, before we dive into the details, I wonder if maybe you can just explain to our listeners who aren't up to speed on what NMOSD is, what the disorder is, and maybe why it's so important that all of our listeners learn how to recognize it quickly and get people started on therapy.  Dr Mariotto: Yes, sure. So, neuromyelitis optica is an inflammatory autoimmune CNS disorder usually associated with aquaporin-4 antibodies, although there are a few cases, around 10%, who can be antibody-negative. And I think it's very much important to have in mind this disease and recognize it because it can be severe, as you pointed out; can present with very severe optic neuritis, myelitis, the brain stem, or area postrema syndrome. So, it can be really severe, affect quite young people around 40 years of age---although it can affect also the pediatric population and elderly people---and, importantly, it can be treated. It's very much important to treat this patient in the acute stage very quickly with steroids or plasma exchange in addition, and then to start a chronic treatment. So, we have treatment for this condition. So, it's very much important to, to recognize it quickly and treat the patient properly.  Dr Smith: So, I wonder if we can talk a little bit about the diagnostic criteria and boundaries of NMOSD, right? So, someone who comes in with bilateral op- severe long segment optic neuritis or long segment myelitis, we think about it. But what are the boundaries? Should we be looking for this, for instance, in someone who comes in with a unilateral optic neuritis or looks like typical multiple sclerosis? Is it important to get aquaporin-4 antibodies in those patients? What do the diagnostic criteria say about this?  Dr Mariotto: So, I wouldn't test aquaporin-4 antibodies in all patients with demyelinating conditions because although aquaporin-4 antibody assay is very specific, as for all assay and all antibody testing---also for MOG antibodies, for example---some false positive results can come out. So, I would suggest to test aquaporin-4 antibodies not in typical MS cases but in those who could be suggestive for not being MS, so in all those cases with atypical optic neuritis and myelitis or other syndromes. For those cases, it's important to test aquaporin-4 antibodies, but I wouldn't test them in all typical, classical MS cases. As I said, it's quite specific, the assay, so it's uncommon to have false positive results, but it can be.  Dr Smith: Serum, CSF, both?  Dr Mariotto: So, for aquaporin-4 antibodies, they're usually present in serum. They can be positive also in the CSF. And there are a few reports of isolated CSF positivity. But if we analyze larger samples volume, then it becomes clear that isolated CSF positivity is so, so rare that it's not recommended to test them in the CSF when serum is negative. So, for aquaporin-4 antibodies, the recommended matrix of testing is serum, which is different for MOG, which is not the topic of our article but is important to mention because MOG antibodies should be tested in serum and CSF. But aquaporin-4, I would recommend to test serum.  Dr Smith: What are the boundaries between MOGAD and NMOSD? And you talked about the differential testing of antibodies, which I was going to ask about. But when should we think of NMOSD relative to MOG? Dr Mariotto: Yeah. There are aspects which are the one mentioned in the criteria, highly suggestive for NMOSD. But the clinical spectrum can be similar to that of MOGAD. Usually, although there are some clinical aspect---like, for example cortical encephalitis or ADEM, which is more typical for MOGAD, or others like area postrema syndrome, which are more typical of NMOSD. The spectrum can be similar among the two conditions, so that's why in our clinical experience, usually they ask both aquaporin-4 and MOG antibodies in patients. It's- for experts, it can be easy to differentiate the two conditions, but for nonexperts can not be so easy.  Dr Smith: Can you define area postrema syndrome? I think not all of our listeners see that every day.  Dr Mariotto: Yeah, sure. This is a syndrome which is highly suggestive of NMOSD. That's why I mention it. And it's characterized by nausea, vomiting, hiccups are known as the syndrome. And it is very, very suggestive because of the expression of aquaporin-4 in that area of NMOSD. That's why I strongly recommend for all patients who comes out to have this syndrome to test for aquaporin-4 antibodies. MOGAD is hardly ever positive for that, so I think that whenever you see a patient with that syndrome, you should think about NMOSD.  Dr Smith: I'm just curious, aquaporin-4 is a water channel, which is kind of an interesting concept. Our conversation, I really want to make sure we give clinically important information to folks, but it's so curious to me at least, how does this actually result in a inflammatory demyelinating syndrome? For a simple neuromuscular guy, what's the immunopathogenesis of this?  Dr Mariotto: Yeah, the immunopathogenesis is quite complicated, as in all CNS disorders. And of course, aquaporin-4 antibodies are the main focus, but they are not the only one. As you said, aquaporin-4 antibodies have a target, this water channel, which is at the basis of the disease, and they are produced by the interplay between T cells, B cells, and plasma cells. But then also eosinophils, macrophages, cytokines, and chemokines are involved, enter the CNS, and then another important component is complement, which is highly activated in this disease. At the end, we have astrocyte damage because astrocytes are the main target of the disease, but also axon and myelin are involved. So, it's a quite complex pathogenesis based on the antibodies, but not only on that.  Dr Smith: And this will become important when we start talking about treatment. There seems to be a recurring theme of long segment demyelination, right? Optic neuritis is typically a large percentage of the length of the optic nerve, and obviously the myelitis se- more than three segments. Do you see other long segment areas of CNS demyelination, corpus callosum or things like that? Any ideas why that is, if that's true?  Dr Mariotto: Of note, this is quite interesting because usually when we have NMOSD, we have a longitudinal involvement, especially of the optic nerve and spinal cord, while brain lesions are quite different. Like, we usually do not have the typical Dawsen fingers-like lesions that we have in MS, for example, or the classical periventricular or subcortical extensive lesions that we can see and we have in mind when we think about MS. In some cases with NMOSD, the brain is completely negative, so we do not see anything. And Dawsen lesion's quite suggestive of NMOSD. So, you're right. I mean, this is related partially to the expression of aquaporin-4, and that's why we have this typical involvement also for area postrema, for example, and maybe also our other examples of clinical aspect that we can see in these conditions. But it's basically linked with the expression of aquaporin-4, which is the main target of the disease. And that's why usually the brain doesn't show so much involvement as we can see in MS, for example.  Dr Smith: I was actually really interested in some of the unusual manifestations or phenotypes, and I don't want to get into arcadia, really, but which of these should our listeners be familiar with that would really suggest that they should be thinking about NMOSD beyond the area postrema and other features that we've already talked about that are part of the core criteria?  Dr Mariotto: Yeah. I mean, I think that the encephalic syndromes or also ADEM, which is most typical of MOGAD but can be observed also in NMOSD or PRES, for example, are syndromes that can be considered in patients with NMOSD. There are the typical ones, which are the ones showed in the criteria, but whenever we have a brainstem involvement or, like, these encephalic syndromes or also PRES, we should think about NMOSD also.  Dr Smith: Another area I was interested in are red flags. In your article, you talk about red flags that might suggest an alternative diagnosis, right? And then this presumably is particularly important in seronegative patients, which 10% is not a reasonably high number, I suppose. What are red flags we should be thinking about for some other diagnosis?  Dr Mariotto: Yeah. I would here mention two very important red flags. The first one is a very hyperacute onset. Usually these conditions, these inflammatory conditions have a subacute onset, so whenever you have a very, very acute onset, you should think about something else. This can occur sometimes also in NMOSD, but hardly ever occur. Like, a very acute myelitis, the first thing we should think about is a vascular origin, for example, with a lot of pain and not about NMOSD, although sometimes the differential diagnosis is not so easy. The second thing is a progression independently of relapses, which hardly ever occur in NMOSD. Usually in NMOSD, we have the onset, and then we have a relapsing disease course. That's why we have to treat patients always and not to stop treatment. But we do not have progression in the meanwhile, while we can have, for example, this in MS. Same thing is for MOGAD. So, these are two things that I think is very much important to keep in mind.  Dr Smith: I want to pivot to talk about treatment because that's been super exciting. But rumor has it there are new diagnostic criteria coming for NMOSD in the next year. I bet you know a bit about those. Can you give our listeners any indication about kind of where the puck is going on this? Not so much what the criteria are specifically, but what sort of diagnostic challenges are the new criteria going to help us with once they come out?  Dr Mariotto: Yeah. So basically, we are working on that, so you will read them in the next future. This is the good point of the conversation on the new criteria. And we work a lot on the definition, on the new definition and nomenclature of NMOSD; on the definition of seronegative NMOSD, which is also quite tricky; and then on the assay we should use to test aquaporin-4 antibodies, and also on potentially new syndromes which should be included into the main feature of the disease. But hopefully you will read about this very soon.  Dr Smith: Looking forward to it. And Continuum Audio listeners, you heard it here first, so thank you. Let's pivot to treatment. This has been super exciting, and I wonder if the way to approach this is to start with acute management and then sort of chronic management. Would that make sense?  Dr Mariotto: Sure.  Dr Smith: Let's say I go on service on Friday, and I have a patient who comes in with positive aquaporin-4 and bilateral optic neuritis. What's the acute approach to managing that patient?  Dr Mariotto: So, the first approach is to administer intravenous steroids, but I would not wait to escalate to plasma exchange. There is quite good evidence that we should treat the patient with additional plasma exchange very quickly, and every day of delay of plasma exchange can cause increased disability. So, we should treat patients with steroids first, and then if we are not satisfied by the recovery, soon start with a plasma exchange. There is also some evidence, although less, for IVIG, but it's important to try to treat them very quickly, even if it's Friday, you know, there is the weekend and so on. But I think it's very much important to start with steroids after excluding other infectious causes or so on, and then to start quickly with plasma exchange. The main problem could be that we do not have the results of the antibody yet.  Dr Smith: Right. So, let me ask that question. You know, let's say my patient comes in on Friday, and clinical syndrome that really looks like NMOSD, and we're waiting for the aquaporin-4. There are many places where it's hard to get plasma exchange over weekends. And so, in that setting, are you better off doing the steroids over the weekend then PLEX on Monday, or should we just give IVIG because maybe it's as good as PLEX? What's your advice there? I'm trying to get ready for Friday because I know one's coming in.  Dr Mariotto: That's true, that's true. Usually they come on Friday or Saturday. I think it's acceptable to have three days of steroids and see how the patient improves, and then after three days to start with plasma exchange. Actually, we have a very good improvement if we start between three and five days after onset. So, I think waiting for three days is acceptable just because we can see if the steroids work properly or not, and then we can quickly start to plasma exchange. But I would not wait, like, 10 days, you know, before starting with a plasma exchange, and I would not wait for antibody results.  Dr Smith: Got it. Super helpful. And I'm actually not joking around, I learned recently that I have a reputation among our residents for having lots of optic neuritis when I'm on service, which I think is sort of karmic justice for being a peripheral nerve expert. But let me ask another question. So, let's say we do that, and the patient gets three or five days of pulse methylprednisolone and five courses of PLEX, and they're not doing well. Do you then just move right along into another agent B cell depletion therapy? I mean, what's your next step in escalation in the acute setting?  Dr Mariotto: I would for sure start to, as you said, with steroids, plasma exchange, and in case IVIG, and then quickly move to chronic treatment. And for patients who are not recovering well, I would think of something which has a quick effect so we can really start treating patients very quickly. There are different options. And all over the world, there are different rules for using immunosuppression in NMOSD. Like in Italy, for example, it's different from US or other countries, Germany, for example. There are different approved treatments and different rules of using them before or after rituximab, for example. We all know that there are treatments approved for NMOSD all over the world. But in some countries, like for example in Italy, we should use rituximab first, and then if it doesn't work, escalate to the approved treatment. I know in the US it's different. But anyway, for a patient who does not improve quickly, I would start with something which has a quick effect on the disease.  Dr Smith: And then rituximab versus inebilizumab, you know, CD20, CD19, what's your advice there? Is one preferable to the other, you know, if we have options to do either?  Dr Mariotto: Yeah. So, between rituximab and inebilizumab, we know that the target, well, is different, but is anyway B cells, so CD19 and CD20. With CD19, we can affect both plasma blast, plasma cells, and B cells. That's why the target is broader. And of note, this is an approved drug, while rituximab is, in most countries, used as off-label treatment.  Dr Smith: So inebilizumab would probably be preferable if we're able to do that.  Dr Mariotto: Unfortunately, there are not so many studies comparing rituximab with the approved drug, which is, of course, a pity, but that's the case. While we have clinical trials for all the approved drugs, and although the trials were designed differently, as we mentioned in the Continuum paper, we can argue something of the comparison between the approved drugs. But it is not so clear the comparison between rituximab and the new drugs, which is also something that we should work on.  Dr Smith: And then for chronic suppressive management, what other options are there?  Dr Mariotto: So, in addition to B cells, target can be interleukin-6, as we know with tocilizumab or satralizumab, and then complement with eculizumab. These drugs are both based on the pathogenesis of the disease. That's why we also discuss it in the paper, which shows a clear involvement of complement, and among cytokines of interleukin-6. So, targeting these made clear that could improve the disease quite well, and that's why they designed some clinical trials on these drugs, which are now approved, as we said, for NMOSD.  Dr Smith: Wow, so many options, and a lot of questions, but limited time. Let me just ask a couple of more. I see a lot of myasthenia patients, and there's a lot of variability, as you know, in patients with myasthenia, the extent to which complement is an important mechanism versus other, you know, important mechanisms. To what extent is response to a complement inhibitor kind of uniform across NMOSD? Or there's some patients who just don't respond to a complement inhibitor and others that respond really well. And then just, I'll just give my second question out is, you know, what about combination therapies for patients who have particularly challenging NMOSD?  Dr Mariotto: So usually these patients have a terrific response to complement inhibitors, and this is also shown by the clinical trials where we saw how eculizumab have a very impressive effect on the disease. And also, maybe this is also your experience, a very quick effect. So that's why there are also thoughts on using it in a very acute stage of the disease. That was what I was thinking about before. But then it has a very huge effect on complement, which is a major factor involved in the pathogenesis of NMOSD also in the chronic disease stage, and that's what also we see from clinical trials. Usually, we prefer to switch treatment from one to another and not to combine them. Of course, in very difficult cases, this can be considered, but the recommendation is to switch from one of these approved drugs to the other, or from rituximab to one of the approved drugs, and try to find out the best for our patient before combining them. Dr Smith: The complement inhibitor trials are breathtaking, at least for me. If I'm trying to convince students to go into neurology, I'll say, "Take a look at that paper," because anyone who claims that we're "diagnose and adios" is so wrong. It's so exciting. So, at a high level, this must have fundamentally changed outcomes for patients. I mean, it's still a difficult disease, but what is the kind of prognosis for that patient I described who comes in, gets the therapy you talked about? What does their long-term outcome look like in this modern therapeutic environment? Dr Mariotto: So, NMOSD is almost always a relapsing disease. That's why, as we mentioned, we have to treat patients always. But the prognosis changes a lot since we were also able to use all these drugs for the disease. So, the prognosis changes if we recognize it properly and early, and if we treat NMOSD properly with immunosuppressives. So, whatever we choose it's important to start it quickly, and this is the only way that we have to improve the prognosis of this disease. We have very active cases, but we have also cases who responds quite well to this immunosuppressive treatment, since now we have, as mentioned, these ones which are very impressive and show incredible results. So, the prognosis of the disease change in the last year, thanks also to the improvement of the diagnosis and of the treatment choices for the disease.  Dr Smith: I'm just... I- maybe my last question, you know, just at a personal level, not only for you as an expert who's caring for these patients, but in the patient community, this must have been a pretty exciting period of time, right? I mean, these, these drugs are coming fast and furious, and what a change. What's the kind of zeitgeist in the community, both your professional community and amongst the patient community about where we are? Dr Mariotto: Yeah, you're right. The last years were defined the years of NMOSD and also MOGAD because we had finally approved drugs which is relevant for all the disease that we treat and changed the landscape of the disease for clinicians, but also for patients. And we have more than one, as we said, so we have more options that we can also discuss with patients to try to choose the best one in terms of activity, but also route of administration or time. Some years ago, we just had rituximab, which is not approved in most of the countries, and now we have different approved drugs. And we improved the diagnosis of the disease thanks to the availability of live cell-based assay. And then we are working a lot also on biomarkers like GFAP, for example, which has been shown to be a very attractive biomarker able to mark disease activity and maybe also prognosis on this disease. So, you're right. I mean, in the last years, the landscape of NMOSD changed a lot.  Dr Smith: Sara, thank you so much for talking with me. I could keep going for another half an hour, but I would be in trouble with my editor, so I think we probably need to wrap it up. But thank you so much. This has been very informative.  Dr Mariotto: My pleasure. Dr Smith: Mine too. Thank you. Again, today I've been interviewing Dr Sara Mariotto about her article on NMOSD, which she wrote with Dr Romain Marignier. This article appears in the April 2026 issue of Continuum on multiple sclerosis. Be sure to check out Continuum Audio episodes from this and other issues, and thanks to you, our listeners, for joining us today. Dr Monteith: This is Dr Teshamae Monteith, Associate Editor of Continuum Audio. If you've enjoyed this episode, you'll love the journal, which is full of in-depth and clinically relevant information important for neurology practitioners. Use the link in the episode notes to learn more and subscribe. AAN members, you can get CME for listening to this interview by completing the evaluation at continpub.com/audioCME. Thank you for listening to Continuum Audio.

Benj, Octane, Aches, Rambo, and Attach break down the final day of the Call of Duty League Minor Tournament and the LA Thieves vs Miami Grand Finals!

The boys break down the CDL Minor 1 tournament, won by the Los Angeles Thieves, with Miami Heretics second, and OpTic Texas and FaZe Vegas falling just short of the grand finals.

On the 231st episode of the Ego Chall Podcast, Justin Binkowski and Preston Byers break down the first Call of Duty League (CDL) Minor of the 2026 season, including the Los Angeles Thieves' finals victory vs. the Miami Heretics, OpTic Texas and FaZe Vegas' eliminations in the semifinals, and more.

FaZe ZooMaa, Benj, Aches, Octane, and Temp break down the Call of Duty League matches from day 2 of the Minor Tournament 4/25/2026!

New users get $50 when they play their first $5 lineup on https://www.prizepicks.com using code: OpTic F*%k your khakis and get The Perfect Jean 15% off with the code OPTIC15 at http://theperfectjean.nyc/OPTIC15 #theperfectjeanpod OpTic Gaming Merch: https://shop.opticgaming.com/ Check out the OpTic SCUF collection and use code “OpTic” for a discount: https://scuf.co/OpTic Check out the OpTic Podcast here: https://podcasts.apple.com/us/podcast/optic-podcast/id1542810047 https://open.spotify.com/show/25iPKftrl0akOZKqS0wHQG 00:00 - Intro 01:15 - Mexico City Trip Recap 15:37 - Pamaj Cooked For Us 16:48 - Mercules LOVES Fishing 18:32 - HECZ Snapped at Borderland Jam 20:35 - The Catalyst 6 is Coming 24:04 - Huntsmen Update (Part 1) 27:37 - Prize Picks 30:59 - The Perfect Jean 33:08 - Huntsmen Update (Part 2) 38:34 - New CDL Meta (MPC) 46:05 - This Tweet was Insane 46:30 - Nameless's Top 10 CDL Players 49:00 - Falcons Post-Match Comms 50:56 - Merc and Dashy Join the Pod 55:46 - Dallas Stars Playoffs 58:03 - Karrigan Leaves FaZe 59:22 - Drake Album Reveal in Toronto 01:00:55 - Japanese Engineers Level Up Fencing 01:02:19 - Answering Your Questions Learn more about your ad choices. Visit megaphone.fm/adchoices

On the 230th episode of the Ego Chall Podcast, Justin Binkowski and Preston Byers discuss the first Call of Duty League (CDL) Minor of the 2026 season, including the chances for OpTic Texas, Major 2 champion FaZe Vegas, Major 1 champion Paris Gentle Mates, the Los Angeles Thieves, and more.

OpTic Gaming Merch: https://shop.opticgaming.com/Check out the OpTic SCUF collection and use code “OpTic” for a discount: https://scuf.co/OpTicCheck out the OpTic Podcast here: https://podcasts.apple.com/us/podcast/optic-podcast/id1542810047https://open.spotify.com/show/25iPKftrl0akOZKqS0wHQGThe Newest Member of Huntsmen | Brack | The Flycast Ep. 187

The boys break down the recent Riyadh Falcons drama, which teams need to make roster changes, and the upcoming CDL Minor 1 tournament.

To explore coverage, visit http://aspcapetinsurance.com/optic. The ASPCA® is not an insurer and is not engaged in the business of insurance. OpTic Gaming Merch: https://shop.opticgaming.com/ Check out the OpTic SCUF collection and use code “OpTic” for a discount: https://scuf.co/OpTic Check out the OpTic Podcast here: https://podcasts.apple.com/us/podcast/optic-podcast/id1542810047 https://open.spotify.com/show/25iPKftrl0akOZKqS0wHQG 00:00 - Intro 01:26 - Are COD 8's Dead? 02:11 - Huntsmen Updates 05:16 - The Time FormaL Saved Scump (Almost) 07:01 - CDL Map Pool Controversy 13:09 - Shotzzy Breaks Down Major 2 14:58 - Rostermania Updates 20:02 - New Streamer Challenge 21:30 - Justin Bieber at Coachella 24:21 - Artemis II Astronauts Return to Earth 26:25 - Moon Landing Fake or Real? 29:20 - He Ran 300 Miles?! 31:07 - Choose Your Rolex 32:33 - The Masters 35:06 - Cooper Flagg the Next MJ? 36:49 - Texas Investigation into Lululemon 38:12 - The $10 Million Question 45:24 - The $5 Billion Question 50:27 - The US Navy Has Dolphin Assassins 53:35 - One Change We'd Make to COD 56:42 - Could We Win the Next Challengers Cup? Learn more about your ad choices. Visit megaphone.fm/adchoices

OpTic Gaming Merch: https://shop.opticgaming.com/Check out the OpTic SCUF collection and use code “OpTic” for a discount: https://scuf.co/OpTicCheck out the OpTic Podcast here: https://podcasts.apple.com/us/podcast/optic-podcast/id1542810047https://open.spotify.com/show/25iPKftrl0akOZKqS0wHQGDad Advice, CDL Drama & Rust | The Flycast Ep. 18500:00 Intro 02:00 Playing Rust 13:00 2B2T Minecraft 27:00 Minecraft forever worlds 43:00 CDL Drama 59:00 CDL Major PC Issues 1:10:00 Dad Advice

Head to http://factormeals.com/optic50off and use code optic50off to get 50 percent off and free daily greens per box! Go to http://rocketmoney.com/optic to reach your financial goals faster. OpTic Gaming Merch: https://shop.opticgaming.com/ Check out the OpTic SCUF collection and use code “OpTic” for a discount: https://scuf.co/OpTic Check out the OpTic Podcast here: https://podcasts.apple.com/us/podcast/optic-podcast/id1542810047 https://open.spotify.com/show/25iPKftrl0akOZKqS0wHQG 00:00 - Intro 03:01 - Mexico City Trip 04:13 - Japan and Anime 06:29 - Easter 08:08 - CDL Rostermania is CRAZY 19:46 - Huntsmen/Challengers 23:12 - Major 3 Pro-Am 28:20 - Faker Honored with Stamp in South Korea 30:17 - Factor 32:03 - Rocket Money 31:14 - He Got DQ'd for Celebrating 35:52 - INSANE Live Case Opening 36:37 - Faze Miss IEM Cologne 38:42 - Artemis II 41:41 - Pilot Rescued 45:06 - WTF is Battlefield 6 45:59 - The Best Sens for CS? 46:24 - HECZ was Right the Whole Time 50:39 - Barstool BigCat's New Purchase 52:39 - Kanye's Return 53:21 - ChatGPT Hallucinations 55:27 - Answering YOUR Questions Learn more about your ad choices. Visit megaphone.fm/adchoices

OpTic Gaming Merch: https://shop.opticgaming.com/Check out the OpTic SCUF collection and use code “OpTic” for a discount: https://scuf.co/OpTicCheck out the OpTic Podcast here: https://podcasts.apple.com/us/podcast/optic-podcast/id1542810047https://open.spotify.com/show/25iPKftrl0akOZKqS0wHQGHITCH IS GOING TO BE A DAD | The Flycast Ep. 185

This show is sponsored by BetterHelp. Sign up and get 10% off at http://BetterHelp.com/optic F*%k your khakis and get The Perfect Jean 15% off with the code at http://theperfectjean.nyc/OPTIC15 #theperfectjeanpod OpTic Gaming Merch: https://shop.opticgaming.com/ Check out the OpTic SCUF collection and use code “OpTic” for a discount: https://scuf.co/OpTic Check out the OpTic Podcast here: https://podcasts.apple.com/us/podcast/optic-podcast/id1542810047 https://open.spotify.com/show/25iPKftrl0akOZKqS0wHQG 00:00 - Intro 01:03 - Scump's Next Movie Purchase (HECZ's Account) 03:11 - Major 2 Thoughts 14:23 - HECZ's Message for the Greenwall 15:55 - Huntsmen Warmup Situation 18:06 - Shotzzy's 200 IQ Play 20:07 - NEW Maps and Weapons (Season 03) 21:26 - The CDL NEEDS More Maps 29:06 - Better Help 30:32 - The Perfect Jean 32:57 - Scump Made Fariko Rage Quit 34:20 - This Gives You Aimbot?! 36:11 - Peanut Plays Halo 3 Customs 39:30 - Formal Was Duck Hunting in Scrims 40:13 - MaNiaC Was Dominating 42:29 - NiaC's Glow-Up 43:05 - Disney to Buy Epic Games? 45:51 - New Gears of War 46:55 - This Mural is INSANE 47:40 - They Turned Down $26 Million 48:54 - Shotzzy Movement in the MLB 51:02 - Tiger Woods 53:37 - UCONN March Madness Learn more about your ad choices. Visit megaphone.fm/adchoices

OpTic Gaming Merch: https://shop.opticgaming.com/Check out the OpTic SCUF collection and use code “OpTic” for a discount: https://scuf.co/OpTicCheck out the OpTic Podcast here: https://podcasts.apple.com/us/podcast/optic-podcast/id1542810047https://open.spotify.com/show/25iPKftrl0akOZKqS0wHQG

FaZe ZooMaa, Parasite, Attach, Octane, Aches, Enable, Temp, and Rambo break down the Call of Duty League matches from Day 2 of Major 2!

FaZe ZooMaa, Parasite, Attach, Octane, Aches, Attach, Benj, and Rambo break down the Call of Duty League matches from Day 2 of Major 2!

Holistic Vision Coach Claudia Muehlenweg joins Dr. Will Cole to discuss why eyesight declines and what may help support healthier vision habits. Claudia shares her story of getting glasses at age three, becoming glasses-free as a teen, and later retraining her vision again during a high-stress season. They unpack the role of chronic stress, nervous system tension, and “tunnel vision,” plus how screens impact blinking, dry eyes, and near-point strain. Claudia also shares practical tools like palming, visual breaks, and building better “visual hygiene,” along with insights on light sensitivity, night vision, and nutrition. For all links mentioned in this episode, visit www.drwillcole.com/podcast.Please note that this episode may contain paid endorsements and advertisements for products and services. Individuals on the show may have a direct or indirect financial interest in products or services referred to in this episode.Sponsors:Right now, Betterwild is offering our listeners up to 40% off your order at betterwild.com/WILLCOLE.For a limited time Hollow Socks is having a Buy 2, Get 2 Free Sale. Head to Hollowsocks.com today to check it out. #HollowSockspod #SPONSORED Go to DRINKAG1.com/WILLCOLE to get an AG1 Flavor Sampler and a bottle of Vitamin D3+K2 for FREE in your AG1 Welcome Kit with your first AG1 subscription order! Produced by Dear Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

OpTic Gaming Merch: https://shop.opticgaming.com/ Check out the OpTic SCUF collection and use code “OpTic” for a discount: https://scuf.co/OpTic Check out the OpTic Podcast here: https://podcasts.apple.com/us/podcast/optic-podcast/id1542810047 https://open.spotify.com/show/25iPKftrl0akOZKqS0wHQG Is the Next Call of Duty the Most Important COD in History? | The OpTic Podcast Ep. 169 00:00 - Intro 01:33 - Call of Duty Major 2 05:14 - State of Halo with FormaL 12:20 - MW19 Debate 18:05 - Could COD Win Game of the Year? 22:52 - Old COD vs New COD 27:40 - Is the Skill Gap Gone? 32:20 - Zin's HILARIOUS Bedtime Routine 33:24 - Marvel/Star Wars/Harry Potter 39:53 - Game of Thrones Universe 41:45 - Can George R.R. Martin Finish the Books? 45:45 - Was Game of Thrones the GOAT Show? 47:42 - The Best and Worst TV Shows of All Time 59:33 - Ultimate 1 of 1 Draft Learn more about your ad choices. Visit megaphone.fm/adchoices

OpTic Gaming Merch: https://shop.opticgaming.com/Check out the OpTic SCUF collection and use code “OpTic” for a discount: https://scuf.co/OpTicCheck out the OpTic Podcast here: https://podcasts.apple.com/us/podcast/optic-podcast/id1542810047https://open.spotify.com/show/25iPKftrl0akOZKqS0wHQG

FaZe ZooMaa, Aches, Parasite, Octane, and Benj Break down the Call of Duty League matches from 3/23/2026!

FaZe ZooMaa, Octane, Aches, Benj, Enable break down the Call of Duty League matches from 3/21/2026!

OpTic Gaming Merch: https://shop.opticgaming.com/Check out the OpTic SCUF collection and use code “OpTic” for a discount: https://scuf.co/OpTicCheck out the OpTic Podcast here: https://podcasts.apple.com/us/podcast/optic-podcast/id1542810047https://open.spotify.com/show/25iPKftrl0akOZKqS0wHQG