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Researchers recently reported new evidence from a study of a medical device placed inside the body, a spine-stimulating implant. 研究人员最近报道了一项对放置在体内的医疗装置的研究的新证据,这是一种刺激脊柱的植入物。 Three people with a muscle-destroying disease got a little stronger after using the implant. They were able to stand and walk more easily because of electrical stimulation to their spinal cord. 使用植入物后,三个患有肌肉疾病的人会变得更强大。 由于对脊髓的电刺激,他们能够更容易站立和走路。 Marco Capogrosso is an assistant professor at the University of Pittsburg, or Pitt, who led the research. "These people were definitely not expecting an improvement," he said. Capogrosso said, "They were getting better and better," over the study that lasted one month. Marco Capogrosso是匹兹堡大学或皮特大学的助理教授,他领导了这项研究。 他说:“这些人绝对不会期望有所改善。” Capogrosso说:“他们越来越好,”持续一个月的研究。The implant was able to return some muscle function, at least temporarily. The implant was already being tested to treat paralysis in other patients. This new evidence suggests it might also aid diseases of the nervous system like spinal muscle atrophy, or SMA. 植入物至少能够暂时恢复某些肌肉功能。 该植入物已经被测试以治疗其他患者的麻痹。 该新证据表明,它也可能有助于神经系统(如脊柱肌肉萎缩或SMA)的疾病。SMA is a genetic disease that slowly destroys motor neurons, nerve cells in the spinal cord that control muscles. That leads muscles to waste away, especially in the legs, hips, and shoulders and sometimes those involved with breathing and swallowing. There is no cure. A gene therapy can save the lives of very young children with a severe form of the disease, and there are some medicines to slow the disease in older patients. SMA是一种遗传疾病,慢慢破坏了控制肌肉的脊髓中的运动神经元,神经细胞。 这会导致肌肉浪费,尤其是在腿部,臀部和肩膀上,有时甚至是呼吸和吞咽的肌肉。 无法治愈。 基因疗法可以挽救患有严重形式疾病的非常小儿童的生命,并且有一些药物可以减慢老年患者的疾病。 Stimulating the spinal cord with low levels of electricity has long been used to treat chronic, or long-term, pain. Capogrosso's team also has tested it to help people paralyzed by strokes or spinal cord injury move their arms and legs with assistance. The system sends electrical signals to nerves that have stopped reacting. This has the effect of activating the muscles. 长期以来,用低水平的电刺激脊髓来治疗慢性或长期疼痛。 Capogrosso的团队还对其进行了测试,以帮助瘫痪或脊髓损伤瘫痪的人们在帮助的情况下移动手臂和腿部。 该系统将电信号发送到停止反应的神经。 这具有激活肌肉的作用。Capogrosso wondered if that same technology might help patients with SMA by stimulating sensory nerves to signal damaged muscle cells causing them to move. The researchers at the University of Pittsburgh published their study in Nature Medicine. Capogrosso想知道,同一技术是否可以通过刺激感觉神经来帮助肌肉细胞发出导致其移动的肌肉细胞来帮助患有SMA的患者。 匹兹堡大学的研究人员发表了他们的自然医学研究。 They implanted electrodes over the lower spinal cord of the three adults with SMA. Using the device did not return normal movement but with a few hours of spinal stimulation a week, all soon experienced improvements in muscle strength and function, the researchers wrote. 他们将电极植入了三个成年人的下脊髓上。 研究人员写道,使用该设备没有返回正常运动,而是每周进行几个小时的脊柱刺激,所有这些都很快就会改善肌肉力量和功能。Fifty-seven-year-old Doug McCullough took part in the study. "With a progressive disease you never get any better," he said, adding, “So having any improvement is just a really surreal and very exciting benefit." 57岁的道格·麦卡洛(Doug McCullough)参加了这项研究。 他说:“有了进步性疾病,您永远不会变得更好,因此,任何改进只是一个非常超现实和非常令人兴奋的好处。” All three subjects increased how far they could walk in six minutes by the study's end. 所有三个受试者都增加了他们在研究结束时可以在六分钟内步行多远。 Capogrosso said they could walk farther because they got less tired and “even a person this many years into the disease can improve." Capogrosso说,他们可以走得更远,因为他们的疲倦减少了,“即使是多年来疾病的人也可以改善”。 Researchers found the improvements did not disappear as soon as the stimulator was turned off. But they did decrease a few months after the study ended. 研究人员发现,一旦关闭刺激器,这些改进就不会消失。 但是在研究结束几个月后,他们确实减少了。 Neuroscientist Susan Harkema led similar studies of stimulation for spinal cord injuries while at the University of Louisville. She warned that the new study is small and did not last very long but said it was an important test of the device. She said it should be tested next with other muscle-degenerating diseases. 神经科学家苏珊·哈克玛(Susan Harkema)在路易斯维尔大学(University of Louisville)进行了类似的对脊髓损伤刺激的研究。 她警告说,这项新研究很小,持续很长时间,但表示这是对该设备的重要测试。 她说,接下来应该对其他肌肉脱生疾病进行测试。 Capogrosso said some small but longer studies are beginning. Capogrosso说,一些很小但更长的研究开始了。
In episode 144, host Kevin Schaefer talks with Doug McCullough from central New Jersey. The author of “A Billion People in the Shadows,” a new book about understanding disability, Doug previously worked at Johnson & Johnson Pharmaceuticals and has a background in public speaking. He talks about growing up with SMA type 3, navigating employment with a disability, and advocating for an inclusive society. Doug's book: https://publishyourpurpose.com/books/a-billion-people-in-the-shadows-the-ultimate-1-hour-guide-to-understanding-disability/ ================================ To take part in our ongoing discussions regarding SMA, please visit http://www.smanewstoday.com/forums
One of the biggest curiosities of our time is that so many people trust coercion over voluntary choice. Doug McCullough lays out why markets are better than mob rule. It's an interesting thought exercise to consider what would your younger self might say if they were to meet you today. What would you tell them? Jon Miltimore shares 6 financial tips he'd give his 18 year old self. One of the most frightening, yet liberating, realizations a person can have is that no one is riding to our rescue. Mike McDaniel says you're on your own--here's what to do about it. Normal men sit at or near the bottom of the intersectional totem pole of politically correct privilege. Cadence McManimon says, it's time to start speaking well of men again. Article of the Day: When you find yourself feeling overwhelmed at the amount of official wickedness being imposed upon humanity, Bill Rice has a timely reminder that should give you hope: The numbers favor our side. Sponsors: Life Saving Food Fifty Two Seven Alliance Iron Sight Brewing Co. Quilt & Sew
Jeffrey Einstein from the Quality of Life Resistance Movement joins me to talk about the tyranny of victimhood culture. If you haven't already subscribed to Jeff's Substack, please consider doing so. Do facts matter any more? James Esses catalogs the the fall of Scientific American from a serious science magazine to just another pseudo-scientific publication pandering to trans-activism. Sure looks like war is on the menu for the Middle East. Doug Casey has some relevant thoughts on the current conflict as well as what comes next. Article of the Day: Free markets are an essential part of personal freedom. Doug McCullough explains why markets are better than mob rule. Sponsors: Monticello College Life Saving Food TMCP Nation Climbing Upward Quilt & Sew
Robert Verbruggen of Manhattan Institute rejoins the program to discuss Asian discrimination in college admissions. Cohosted by Josiah Neeley and Doug McCullough.
National Review editor and Bloomberg contributor Ramesh Ponnuru visits the show again to discuss the recent SCOTUS leak, the draft Alito opinion, and the future of abortion law in the United States. Cohosted by Josiah Neeley and Doug McCullough.
What do Charlemagne and Bismarck tell us about the future of Twitter? Samo Burja and Josiah Neeley discuss the Great Founder Theory and how it plays out across society. Produced by Doug McCullough.
Join us for a conversation with Matthew Schmitz of Compact Magazine. Cohosted by Josiah Neeley of R Street Institute and Doug McCullough.
Peter Rough, Senior Fellow of the Hudson Institute, rejoins the show to discuss the Russian invasion of Ukraine, NATO's response, and the resulting changes to German security and energy policies. Cohosted by Josiah Neeley of R Street Institute and Doug McCullough.
Caleb Watney of the Institute for Progress to talk about progress-oriented policy solutions. We discuss energy, environment, public health crises and more. Cohosted by Josiah Neeley of R Street Institute and Doug McCullough from Committee for Justice
#151: Darren Cabral - How To Move To The USA w/ cohost Sarah Larbi On this episode Gary shares the hosting seat with Sarah Larbi, as they interview investor and entrepreneur Darren Cabral. Darren has spent some times since the pandemic researching the business climate in the US, and deciding if he wants to move there for business and personal reasons. Darren, Sarah and Gary discuss various Visa and non visa ways of living and working in the US, and how to find the right professionals to help you decide if a move Stateside is right for you and your family. Subscribe and listen to find out HOW! WHAT YOU'LL LEARN: The tax implications of moving and doing business in the US, with its unique tax structure. How to finance real estate deals in the States FROM Canada Do you lose your OHIP coverage? How long can you stay there with an E1 or E2 Visa? Does your credit history follow you from Canada? If you bring your family, does your Visa cover them, or do they need to find work? If you have relatives there, is the process more simple or complex? Can I be sponsored? It depends! What types of businesses are they looking for, and do you need to bring capital? Do you have to become a US citizen? How does this work if I choose to go to school there? What about vaccination status? What are the best states to consider? And MORE! Bio After building and selling several small businesses before the age of 22, I fell in love with the process of marketing and scaling businesses through online channels. I doubled down on my strengths and launched my own marketing agency in late 2016, Suits Social Inc. Helping businesses across Canada do just that. About Suits Social - My Social Media Marketing Agency We're a team of millennial marketers that work with businesses, brands, and marketing teams to develop and implement proven social media strategies that drive growth and measurable ROI through paid, influencers, and organic campaigns in a way that is relevant to today's consumer. Visit us online at www.SuitsSocial.com Clients include one of North America's largest auto groups, national retail franchises, one of Ontario's largest real estate teams, Canada's fastest growing E-Commerce brands, and dozens of brick and mortar businesses around the world. Obscurity To Authority Podcast I'm also the host of a podcast called “Obscurity to Authority”. Where I interview industry leaders who have gone from unknown to know and built massive success in the process. Website/contact info for guest https://www.suitssocial.com/ 705-417-3233 X101 Darren@suitssocial.com Insta: @darrencabral Darren's contacts who have helped him along the way: Canadian Contacts Joel Guberman – Direct Line: 416.304.9551 Email: guberman@cilf.ca – Toronto Immigration Lawyer For Visa Application Ryan Bouskill -Email: rbouskill@djb.com – Hamilton-based CPA for corporate structure and set up in the US US CONTACTS Tobias JW McFaul TJM@weinsteinspira.com – Texas Accountant/CPA specializing in working with Canadians. Doug McCullough McCullough Sudan PLLC | mccullough@dealfirm.com – Texas Corporate Law Firm specializing in working with Canadians. This episode proudly sponsored by Brian Daley @ AGHI Home Inspections. Whether buying or selling a property, AGHI recognizes that the process can be stressful. It is critical that any decision you make be one that is based on knowing all of the facts. Purchasers, vendors, insurance companies and lending institutions have come to recognize the professionally trained residential home inspector as a credible source of key information vital to making these decisions, and AGHI has been doing it for over 15 years! Contact http://www.bookahomeinspection.com or call (416) 526-7482 Other Links: Private Investing, visit https://deep-pockets.ca Real Estate Investment Club visit https://www.smarthomechoice.ca Gary's mentorship program visit https://garyhibbert.ca Start your own Podcast visit https://www.podcastexperts.ca
Eric Kauffman, adjunct professor of politics at Birkbeck, University of London and adjunct fellow of the Manhattan Institute joins us to discuss his recent research into identity and social politics. All nudity was tasteful and essential to the plot. Cohosted by Josiah Neeley of R Street Institute and Doug McCullough.
Author Richard Hanania returns to the show to discuss his book Public Choice Theory and the Illusion of Grand Strategy: How Generals, Weapons Manufacturers, and Foreign Governments Shape American Foreign Policy (Routledge Studies in US Foreign Policy). Cohosted by Josiah Neeley of the R Street Institute and Doug McCullough. Order the book here: https://www.amazon.com/Public-Choice-Theory-Illusion-Strategy-ebook/dp/B09L9Y2W7S
Razib Khan returns to the show to discuss the recent controversy from that pop science magazine about the legacy of EO Wilson, the politicization of academia. He also answers impertinent questions about Celts. Cohosted by Josiah Neeley of R Street Institute (probably a Celt) and Doug McCullough (definitely a Sarmatian)
America's sweetheart, Kate Hyde, rejoins the show for our annual review the bygone year. Cohosted by Josiah Neeley of R Street Institute and Twitter quitter Doug McCullough.
Pascal-Emmanuel Gobry (PEG) returns to the show to discuss the upcoming French elections. Cohosted by Josiah Neeley of L'Institute R Street and Doug McCullough.
Join us for a conversation about class action lawsuit abuse with Ted Frank of the Hamilton Lincoln Law Institute. Cohosted by Josiah Neeley of the R Street Institute and Doug McCullough.
Join us for a conversation with author Chris Arnade about his adventures across the fruited plain seeking dignity in "Back Row America." Co-hosted by Josiah Neeley of R Street Institute and Doug McCullough.
Ross Douthat, NYT columnist and author of "The Deep Places A Memoir of Illness and Discovery," "The Decadent Society" and more, joins us to talk about his journey dealing with chronic illness. Cohosted by Josiah Neeley of R Street Institute and Doug McCullough. "The Deep Places" can be purchased here: https://www.amazon.com/Deep-Places-Memoir-Illness-Discovery/dp/0593237366
Aaron Sibarium of the Free Beacon joins us to discuss L'Affair Yale Trap House Cohosted by Josiah Neeley of R Street Institute and Doug McCullough
Author James Poulos joins us to discuss his latest book "Human Forever: The Digital Politics of Spiritual War." Cohosted by Josiah Neeley of R Street Institute and Doug McCullough.
Alex Bozmoski & Nate Hochman, authors of the recent "The Future of Conservative Climate Leadership" join us to talk about the EcoRight. Cohosted by Josiah Neeley of R Street Institute and Doug McCullough of the Lone Star Policy Institute. ALEX BOZMOSKI is the vice president for programs at DEPLOY/US. NATE HOCHMAN is an Intercollegiate Studies Institute fellow at National Review and a recent graduate of Colorado College.
Robert Lawson, director of the Bridwell Institute for Economic Freedom at the Southern Methodist University (SMU) Cox School of Business, and author of "Socialism Sucks - Two Economists Drink their Way Through the Unfree World" joins us to talk about socialism, beer, and what's so great about economic freedom. Co-hosted by Josiah Neeley of R Street Institute and Doug McCullough of Lone Star Policy Institute.
Adam Millsap, Senior Fellow of Stand Together and Charles Koch Institute, and Forbes magazine contributor to talk all things economic freedom, the decline and renewal of the Midwest, and economic recovery from the COVID19 pandemic. Cohosted by Josiah Neeley of R Street Institute and Doug McCullough of Lone Star Policy Institute.
Carl Szabo of Net Choice joins the show for a conversation about regulating social media and preserving consumer choice. Hosted by Doug McCullough of Lone Star Policy Institute.
Philippe Lemoine joins the show for a long form conversation about the Covid pandemic and why he believes Covid will soon be endemic. Cohosted by Josiah Neeley of R Street Institute and Doug McCullough of Lone Star Policy Institute.
Richard Hanania, fellow of Defense Priorities, joins us to discuss the withdrawal from Afghanistan. Co-hosted by Josiah Neeley of R Street Institute and Doug McCullough of Lone Star Policy Institute.
Join us for a feel good conversation about Covid, Cuomo, Kabul, rising crime, and solutions with Michael Hendrix of Manhattan Institute. Cohosted by Josiah Neeley of R Street Institute and Doug McCullough of Lone Star Policy Institute.
Author Mathew Mehan Director of Academic Programs for Hillsdale in Washington DC joins us to talk about early education and his new book "The Handsome Little Cygnet" Cohosted by Josiah Neeley of R Street Institute and Doug McCullough of Lone Star Policy Institute. The Handsome Little Cygnet available here: https://www.amazon.com/Handsome-Little-Cygnet-Matthew-Mehan/dp/1505120608
Tanner Greer returns to the program to discuss the long view of the culture war. Cohosted by Josiah Neeley of R Street Institute and Doug McCullough of Lone Star Policy Institute.
Charles Fain Lehman of Manhattan Institute and City Journal joins us to discuss the rise of crime during the pandemic and ways to respond to it. Cohosted by Josiah Neeley of R Street Institute and Doug McCullough of Lone Star Policy Institute.
Tatiana Bolton of R Street Institute joins us the program to discuss recent cyber attacks, cyber security policy, and how we can make our own digital lives more secure. Co-hosted by Josiah Neeley of R Street Institute and Doug McCullough of Lone Star Policy Institute.
Today on Podcasting Stories, we're talking with Doug McCullough, an attorney in Houston, the Lone Star Policy Institute director, and podcast host of The Urbane Cowboys podcast with almost 150 episodes. Doug has a lot of experience podcasting and many great lessons to share for anyone considering a podcast, including an interesting insight that he didn't feel he's received much business from his podcast, but he has received business from being on other people's podcasts. People felt comfortable having him as a guest on their shows because he has a podcast of his own, and this indirect benefit of having a podcast ended up resulting in new business for his firm. This is a great episode. Doug's a very interesting guy, and you'll really enjoy what he has to share. LINKSShow Notes TranscriptBe a Guest About YourPodcast.team About McCullough Sudan About The Urbane Cowboys Podcast GUEST Doug McCulloughAbout Doug Special Guest: Doug McCullough.
Dylan Pahman of the Acton Institute and Journal of Markets and Morality join us to discuss whether there was a missed opportunity for a moral or religious revival during the pandemic. Cohosted by Josiah Neeley of R Street Institute and Doug McCullough of Lone Star Policy Institute.
Allison Schrager, senior fellow at Manhattan Institute, Bloomberg columnist, and author of "An Economist Walks into a Brothel" joins us to discuss the headwinds along the way to an economic recovery. Hosted by Doug McCullough of Lone Star Policy Institute.
Adam Gurri, editor in chief and publisher of Liberal Currents, joins us to talk about liberalism and society. Cohosted by Josiah Neeley of R Street Institute and Doug McCullough of Lone Star Policy Institute.
Ilya Shapiro, vice president and direct of Robert A. Levy Center for Constitutional Studies at Cato Institute and author of "Supreme Disorder" joins the show to discuss the latest legislative proposal to pack the US Supreme Court. Cohosted by Josiah Neely of R Street Institute and Doug McCullough of Lone Star Policy Institute.
On this episode, Elio interviews Doug McCullough, Co-Founder of Color Coded Labs, Co-Founder of Black Tech Columbus, and CIO of the City of Dublin, Ohio. Color Coded Labs finds, trains, and sets people of color up at companies ready to innovate at a greater scale. Doug shares his passion for jazz, how musical composition translates to coding, and why Color Coded Labs is what we need to close the wage gap in this country and increase the number of people of color working, leading and founding companies in the tech industry. Enjoy! --- Support this podcast: https://anchor.fm/614startups/support
Alex Muresianu from Tax Foundation joins us to talk vehicle miles tax, his beloved capital expenditure expensing, and all things tax. Cohosted by Josiah Neeley of R Street Institute and Doug McCullough of Lone Star Policy Institute.
Saurabh Sharma of American Moment visits the show to talk about his new organization. Cohosted by Josiah Neeley and Doug McCullough.
Filmmaker Christopher Rufo joins us to discuss critical race theory and its influence on media and culture. Cohosted by Josiah Neeley of R Street Institute and Doug McCullough of Lone Star Policy Institute.
Mike Haugh of R Street Institute joins us to tell us the sordid tale of bribery and political intrigue in the Ohio nuclear energy sector. Cohosted by Josiah Neeley of R Street Institute and Doug McCullough of Lone Star Policy Institute.
Join us for a conversation with urbanist Nolan Gray about Star Wars, its superiority over Star Trek, and why think tankers are the true Jedi. Cohosted by Josiah Neeley of R Street Institute and Doug McCullough of Lone Star Policy Institute.
Joshua Rhodes, Research Fellow at the Webber Energy Group at the University of Texas, joins us to explain what went wrong with the Texas grid this week. Cohosted by Josiah Neeley of R Street Institute and Doug McCullough of Lone Star Policy Institute.
Frequent flyer Sam Hammond joins the show to talk about the Romney child tax credit. Cohosted by Josiah Neeley of the R Street Institute and Doug McCullough of the Lone Star Policy Institute.
James Wallner of the R Street Institute joins us to talk about Trump Impeachment 2.0, and the constitutional and procedural issues with impeaching/convicting a former public official. Cohosted by Josiah Neeley of R Street Institute and Doug McCullough of Lone Star Policy Institute.
Special guests Josiah Neeley of R Street Institute (yes, THE Josiah Neeley) and Razib Khan of Unsupervised Learning join solo host Doug McCullough to explain what went wrong with the American Covid-19 response, and what we could have done better.
Richard Hanania, President of Defense Priorities joins us to discuss the prospects of a new American civil war. Cohosted by Josiah Neeley of R Street Institute and Doug McCullough of Lone Star Policy Institute.
Kate Hyde rejoins the show for our third annual year in review. Cohosted by Josiah Neeley of R Street Institute and Doug McCullough of Lone Star Policy Institute. Produced by Braden McCullough.
Upwork economist Adam Ozimek to discuss the economics of remote work, aliens, and the economics of aliens. Cohosted by Josiah Neeley of R Street Institute and Doug McCullough of Lone Star Policy Institute. Produced by Braden McCullough