Podcasts about ME2

Limb-girdle muscular dystrophies (LGMDs) encompass a group of genetically heterogeneous skeletal muscle disorders. There has been an explosion of newly identified LGMD subtypes in the past decade, and results from preclinical studies and early-stage clinical trials of genetic therapies are promising for future disease-specific treatments. In this episode, Gordon Smith, MD, FAAN, speaks with Teerin Liewluck, MD, FAAN, FANA, author of the article “Limb-Girdle Muscular Dystrophies” in the Continuum® October 2025 Muscle and Neuromuscular Junction Disorders issue. Dr. Smith is a Continuum® Audio interviewer and a professor and chair of neurology at Kenneth and Dianne Wright Distinguished Chair in Clinical and Translational Research at Virginia Commonwealth University in Richmond, Virginia. Dr. Liewluck is a professor of neurology at the Division of Neuromuscular Medicine and Muscle Pathology Laboratory at Mayo Clinic College of Medicine in Rochester, Minnesota. Additional Resources Read the article: Limb-Girdle Muscular Dystrophies Subscribe to Continuum®: shop.lww.com/Continuum Earn CME (available only to AAN members): continpub.com/AudioCME Continuum® Aloud (verbatim audio-book style recordings of articles available only to Continuum® subscribers): continpub.com/Aloud More about the American Academy of Neurology: aan.com Social Media facebook.com/continuumcme @ContinuumAAN Host: @gordonsmithMD Guest: @TLiewluck Full episode transcript available here Dr Jones: This is Dr Lyell Jones, Editor-in-Chief of Continuum. Thank you for listening to Continuum Audio. Be sure to visit the links in the episode notes for information about earning CME, subscribing to the journal, and exclusive access to interviews not featured on the podcast. Dr Smith: This is Dr Gordon Smith with Continuum Audio. Today I'm interviewing Dr Teerin Liewluck, a good friend of mine at the Mayo Clinic, about his article on the limb girdle muscular dystrophies. This article appears in the October 2025 Continuum issue on muscle and neuromuscular junction disorders, a topic that is near and dear to my heart. Teerin, welcome to the podcast, and maybe you can introduce yourself to our listeners. Dr Liewluck: Thank you very much, Gordon, and I want to say hi to all the Continuum fans. So, I'm Dr Teerin Liewluck, I'm the professor of neurology at Mayo Clinic in Rochester, Minnesota. So, my practice focus on all aspects of muscle diseases, both acquired and genetic myopathies. Glad to be here. Dr Smith: I just had the great pleasure of seeing you at a seminar in Houston where you talked about this topic. And so, I'm really primed for this conversation, which I'm very excited about. I find this topic a little hard, and I'm hoping I can learn more from you. And I wonder if, as we get started, recognizing many of our listeners are not in practices focused purely on muscle disease, maybe you can provide some context about why this is important for folks doing general neurology or even general neuromuscular medicine? Why do they need to know about this? Dr Liewluck: Yes, certainly. So, I would say limb girdle muscular dystrophy probably the most complex category of subgroup of muscle diseases because, by itself, it includes thirty-four different subtypes, and the number's still expanding. So, each subtype is very rare. But if you group together, it really have significant number of patients, and these patients present with proximal weakness, very high CK, and these are common patients that can show up in the neurology clinic. So, I think it's very important even for general neurologists to pick up what subtle clues that may lead to the diagnosis because if we are able to provide correct diagnosis for the patients, that's very important for patient management. Dr Smith: So, I wonder if maybe we can talk a little bit about the phenotype, Terran. I mean, your article does a great job of going over the great diversity. And you know, I think many of us here, you know, limb girdle muscular dystrophy and we think of limb girdle weakness, but the phenotypic spectrum is bananas, right? Rhabdomyolysis, limb girdle distal myopathy. I mean, when should our listeners suspect LGMD? Dr Liewluck: Yes, I think by the definition to all the LGMD patients will have limb girdle of proximal weakness and very high CK. So, these are common phenotypes among thirty-four different subtypes. But if it did take into details, they have some subtle differences. In the article, what I try to simplify all these different subtypes that we can categorize at least half of them into three main group that each group the underlying defect sharing among those subtypes and also translate into similar muscles and extra muscular manifestations. You will learn that some of the limb girdle muscular dystrophy may present with rhabdomyolysis. And we typically think of this as metabolic myopathies. But if you have a rhabdomyolysis patient, the CK remain elevated even after the acute episode, that's the key that we need to think this could be LGMD. That's for an example. Dr Smith: So, I wonder if maybe we can start there. I was going to go in a different direction, but this is a good transition. It's easy to see the opportunity to get confused between LGMD or, in that case, a metabolic myopathy or other acquired myopathies. And I think particularly adult neurologists are more accustomed to seeing acquired muscle disease. Are there particular clues that, or pearls that adult neurologists seeing patients with muscle disease can use to recognize when they should be thinking about LGMD given the diverse phenotype? Dr Liewluck: Yes. What I always tell the patient is that there are more than a hundred different types of muscle diseases, but we can easily divide into groups: acquired and genetic or hereditary. So, the acquired disease is when you encounter the patients who present with acute or subacute cause of the weakness, relatively rapidly progressive. But on the opposite, if you encounter the patient who present with a much more slowly progressive cause of weakness over several months or years, you may need to think about genetic disease of the muscle with also including limb-girdle muscular dystrophy. The detailed exam to be able to distinguish between each type of muscular dystrophy. For example, if proximal weakness, certainly limb girdle muscular dystrophy. If a patient has facial weakness, scapular winking, so you would think about facial scapular hematoma dystrophy. So, the slowly progressive cause of weakness, proximal pattern of weakness, CK elevation, should be the point when you think about LGMD. Dr Smith: So, I have a question about diagnostic evaluation. I had a meeting with one of my colleagues, Qihua Fan, who's a great peripheral nerve expert, who also does neuromuscular pathology. And we were talking about how the pathology field has changed so much over the last ten years, and we're doing obviously fewer muscle biopsies. Our way of diagnosing them has changed a lot with the evolution of genetic testing. What's your diagnostic approach? Do you go right to genetic testing? Do you do targeted testing based on phenotype? What words of wisdom do you have there? Dr Liewluck: Yes, so, I mean, being a muscle pathologist myself, it is fair to say that the utility of muscle biopsies when you encounter a patient with suspects that limb girdle muscular dystrophy have reduced over the year. For example, we used to have like fifteen, seventeen hundred muscle biopsies a year; now we do only thirteen hundred biopsies a year. Yes, as you pointed out, the first step in my practice if I suspect LGMD is to go with genetic testing. And I would prefer the last gene panel that not only include the LGMD, but also include all other genetic muscle disease as well as the conjunctive myopic syndrome, because the phenotype can be somehow difficult to distinguish in certain patients. Dr Smith: So, do you ever get a muscle biopsy, Teerin? I mean you obviously do; only thirteen hundred. Holy cow, that's a lot. So, let me reframe my question. When do you get a muscle biopsy in these patients? Dr Liewluck: Muscle biopsy still is present in LGMD patients, it's just we don't use it at the first-tier diagnostic test anymore. So, we typically do it in selected cases after the genetic testing in those that came back inconclusive. As you know, you may run into the variant of unknown significance. You may use the muscle biopsy to see, is there any histopathology or abnormal protein Western blot that may further support the heterogenicity of the VUS. So, we still do it, but it typically comes after genetic testing and only in the selected cases that have inconclusive results or negative genetic testing. Dr Smith: I'd like to ask a question regarding serologic testing for autoantibodies. I refer to a really great case in your article. There are several of them, but this is a patient, a FKRP patient, who was originally thought to have dermatomyositis based on a low-titer ME2 antibody. You guys figured out the correct diagnosis. We send a lot of antibody panels out. Wonder if you have any wisdom, pearls, pitfalls, for how to interpret antibody tests in patients with chronic myopathies? We send a lot of them. And that's the sort of population where we need to be thinking about limb-girdle muscular dystrophies. It's a great case for those, which I hope is everyone who read your article in detail. What do you have to say about that? Dr Liewluck: Yes, so myositis antibodies, we already revolutionized a few of muscle diseases. I recall when I finished my fellowship thirteen years ago, so we don't really have much muscle myositis antibodies to check. But now the panel is expanded. But again, the antibodies alone cannot lead to diagnosis. You need to go back to your clinical. You need to make sure the clinical antibodies findings are matched. For example, if the key that- if the myocytes specific antibodies present only at the low positive title, it's more often to be false positive. So, you need to look carefully back in the patient, the group of phenotypes, and when in doubt we need to do muscle biopsies. Now on the opposite end, the other group of the antibody is the one for necrotizing autoimmune myopathy; or, the other name, immune-mediated necrotizing myopathy. This is the new group that we have learned only just recently that some patients may present as a typical presentation. I mean, when even thinking about the whole testing autoimmune myopathy, we think about those that present with some acute rapidly progressive weakness, maybe has history of sudden exposures. But we have some patients that present with very slowly progressive weakness like muscular dystrophies. So now in my practice, if I encounter a patient I suspect LGMD, in addition to doing genetic testing for LGMD, I also test for necrotizing doing with myopathy antibodies at the same time. And we typically get antibody back within what, a week or two, but projected testing would take a few months. Dr Smith: Yeah. And I guess maybe you could talk a little bit about pitfalls and interpretation of genetic tests, right? I think you have another case in your article, and I've certainly seen this, where a patient is misdiagnosed as having a genetic myopathy, LGMD, based on, let's say, just a misinterpretation of the genetic testing, right? So, I think we need to think of it on both sides. And I like the fact that the clinical aspects of diagnosis really are first and foremost most important. But maybe you can talk about wisdom in terms of interpretation of the genetic panel?  Dr Liewluck:Yes. So genetic testing, I think, is a complex issue, particularly for interpretation. And if you're not familiar with this, it's probably best to have your colleagues in genetics that help looking at this together. So, I think the common scenario we encounter is that in those dystrophies that are autosomal recessive, so we expect that the patient needs to have two abnormal copies of the genes to cause the disease. And if patients have only one abnormal copy, they are just a carrier. And commonly we see patients refer to us as much as dystrophy is by having only one abnormal copy. If they are a carrier, they should not have the weakness from that gene abnormality. So, this would be the principle that we really need to adhere. And if you run into those cases, then maybe you need to broaden your differential diagnosis. Dr Smith: I want to go back to the clinical phenomenology, and I've got a admission to make to you, Teerin. And I find it really hard to keep track of these disorders at, you know, thirty-four and climbing a lot of overlap, and it's hard to remember them. And I'm glad that I'm now going to have a Continuum article I can go to and look at the really great tables to sort things out. I'm curious whether you have all these top of mind? Do you have to look at the table too? And how should people who are seeing these patients organize their thoughts about it? I mean, is it important that you memorize all thirty-four plus disorders? How can you group them? What's your overall approach to that? Dr Liewluck: I need to admit that I've not memorize all twenty-four different subtypes, but I think what I triy to do even in my real-life practice is group it all together if you can. For example, I think that the biggest group of these LGMD is what we call alpha-dystroglycanopathies. So, this include already ten different subtypes of recessive LGMD. So alpha-dystroglycan is the core of the dystrophin-associated glycoprotein complex. And it's heavy glycosylated protein. So, the effect in ten different genes can affect the glycosylation or the process of adding sugar chain to this alpha-dystroglycan. And they have similar features in terms of the phenotype. They present with proximal weakness, calf pseudohypertrophy, very high CK, some may have recurrent rhabdomyolysis, and cardiac and rhythmic involvement are very common. This is one major group. Now the second group is the limb-girdle muscular dystrophy due to defective membrane repair, which includes two subtypes is the different and on dopamine five. The common feature in this group is that the weakness can be asymmetric and despite proximal weakness, they can have calf atrophy. On muscle biopsy sometimes you can see a myeloid on the muscle tissues. And the third group is the sarcoglycanopathy, which includes four different subtypes, and the presentation can look like we share. For the rest, sometimes go back to the table. Dr Smith: Thank you for that. And it prompts another question that I always wonder about. Do you have any theories about why such variability in the muscle groups that are involved? I mean, you just brought up dystroglycanopathy, for instance, as something that can cause a very distal predominant myopathy; others do not. Do we at this point now have an understanding given the better genetics that we have on this and work going on in therapeutic development, which I want to get to in a minute, that provides any insight why certain muscle groups are more affected? Dr Liewluck: Very good question, Gordon. And I would say the first question that led me interested in muscle disease---and this happened probably back in 2000 when I just finished medical school---is why, why, why? Why does muscle disease tend to affect proximal muscles? I thought by now, twenty-five years later, we'd have the answer. I don't. I think this, you don't know clearly why muscle diseases, some affect proximal, some affect distal. But the hypothesis is, and probably my personal hypothesis is, that maybe certain proteins may express more in certain muscles and that may affect different phenotypes. But, I mean, dysferlin has very good examples that can confuse us because some patients present with distal weakness, some patients present with proximal weakness, that's by the same gene defect. And in this patient, when we look at the MRI in detail, actually the patterns of fatty replacements in muscle are the same. Even patient who present clinically as a proximal or distal weakness, the imaging studies show the same finding. Bottom line, we don't know. Dr Smith: Yeah, who knew it could be so complex? Teerin, you brought up a really great point that I wanted to ask about, which is muscle MRI scan, right? We're now seeing studies that are doing very broad MR imaging. Do you use some muscle MRI very frequently in your clinical evaluation of these patients? And if so, how? Dr Liewluck: Maybe I don't use it as much as I could, but the most common scenario I use in this setting is when I have the genetic testing come back with the VUS. So, we look at each VUS, each gene in detail. And if anything is suspicious, what I do typically go back to the literature to see if that gene defect in particular has any common pattern of muscle involvement on the MRI. And if there is, I use MRI as one of the two to try to see if I can escalate the pathogenicity of that VUS. Dr Smith: And a VUS is a “Variant of Unknown Significance,” for our listeners. I'm proud that I remember that as a geneticist. These are exciting times in neurology in general, but particularly in an inherited muscle disease. And we're seeing a lot of therapeutic development, a lot going on in Duchenne now. What's the latest in terms of disease-modifying therapeutics and gene therapies in LGMD? Dr Liewluck: Yes. So, there are several precritical and early-phase critical trials for gene therapy for the common lymphoma of muscular dystrophies. For example, the sarcoglycanopathies, and they also have some biochemical therapy that arepossible for the LGMD to FKRP. But there are many things that I expect probably will come into the picture broader or later phase of critical tryouts, and hopefully we have something to offer for the patients similar to patients with Duchenne muscular dystrophy. Dr Smith: What haven't we talked about, I mean, holy cow? There's so much in your article. What's one thing we haven't talked about that our listeners need to hear? Dr Liewluck: Good questions. So, I think we covered all, but often we get patients with proximal weakness and high CK, and they all got labeled as having limb-girdlemuscular dystrophy. What I want to stress is that proximal weakness and high CK is a common feature for muscle diseases, so they need to think broad, need to think about all possibilities. Particularly don't want to miss something treatable. Chronic, slowly progressive cause, as I mentioned earlier, we think more about muscle dystrophy, but at the cranial range, we know that rare patients with necrotic autonomyopathy and present with limb good of weakness at a slowly progressive cost. So, make sure you think about these two when suspecting that LGMD patient diabetic testing has come back inconclusive. Dr Smith: Well, that's very helpful. And fortunately, there's several other articles in this issue of Continuum that help people think through this issue more broadly. Teerin, you certainly don't disappoint. I enjoyed listening to you about a month ago, and I enjoyed reading your article a great deal and enjoy talking to you even more. Thank you very much. Dr Liewluck: Thank you very much, Gordon. Dr Smith: Again, today I've been interviewing Dr Teerin Liewluck about his article on limb-girdle muscular dystrophy, which appears in the October 2025 Continuum issue on muscle and neuromuscular junction disorders. Please be sure to check out Continuum Audio episodes for this and other issues. And thanks to our listeners for joining today. Dr Monteith: This is Dr Teshamae Monteith, Associate Editor of Continuum Audio. If you've enjoyed this episode, you'll love the journal, which is full of in-depth and clinically relevant information important for neurology practitioners. Use the link in the episode notes to learn more and subscribe. AAN members, you can get CME for listening to this interview by completing the evaluation at continpub.com/audioCME. Thank you for listening to Continuum Audio.

SUBSCRIBE to our newsletter: https://riskreversalmedia.beehiiv.com/subscribe Dan Nathan & Guy Adami break down the top market headlines and bring you stock market trade ideas for Wednesday, August 13th Stallone Clip: https://www.youtube.com/watch?v=mE2-7a_F_B0 --Learn more about FactSet: https://www.factset.com/lp/mrkt-callMRKT Call is brought to you by our presenting sponsors CME Group, FactSet, SoFi & MoneyLionSign up for our emailsFollow us on Twitter @MRKTCallFollow @GuyAdami on TwitterFollow @CarterBWorth on TwitterFollow us on Instagram @RiskReversalMediaLike us on Facebook @RiskReversalWatch all of our videos on YouTube Learn more about your ad choices. Visit megaphone.fm/adchoices

Frame 185 - Personalised Chalk Holders. It's been a while, but they're back. On a hot 19th June daytime Me1 and Me2 sweated it out to see if they could break the stalemate in this contest. Their playing space is too small and they mainly have to use child cues but they still pulled it out of the pocket for a thrilling frame. Though Rich forgot to turn his mic on and then blamed Chris Evans (not that one) so sorry if the sound quality is no good. Thanks to justgiving.com for their kindness and donation to the sport. If you'd like to support our endeavours then why not become a monthly badger at gofasterstripe.com/badges

Frame 184 - Broken Glass. It's an unprecedented morning frame of Me1 vs Me 2 snooker with the action starting before midday, surely putting night owl Me2 at a disadvantage. And there's controversy and possible actionable sexual harassment from the start, but that's what you get when Trump is in charge (Donald, not Judd). Another crucial frame in this never-ending tournament. Who will win? Who indeed? One of the two probably. Forgot to mention that more self-playing snooker memorabilia will be going up on eBay this weekend. Check out https://www.ebay.co.uk/usr/herring1967 and bid for a bit of the original table or one of Richard's original balls.

Josh is joined by the star of the pod, Matt, along with the Lovely Dan from Casting Views to celebrate 15 years of Mass Effect 2 Greetings, Commander (0:00) What is Casting Views? (2:52) How hyped were we for ME2 upon original release? (4:37) The story of Mass Effect 2 (11:47) Preferred ME2 classes and play styles (18:55) The main plot of the game and building your crew (25:33) Favorite ME2 crew member(s) (28:33) Mass Effect controversies (39:26) Bad romance endings? (42:05) Miranda the white whale? (46:05) The final mission (51:43) ME2 DLC (58:10) Social media plugs (1:11:54) Please remember to check out the Casting Views podcast, join our Discord and check out our merch store! 

Frame 181 - No Sound. Me1 and Me2 are back in a new arena, with a new board and a very shoddy affair all round. If you're listening to the audio there's a good 5 to 10 minutes with no sound as Rich didn't turn on his mics, but we're leaving that in so you can enjoy it. If you're watching in video it's just as confusing. The referee loses track of who is who and the constricted new space is not fit for the sport, but the board is as flat as a pancake. So it's business as usual. Why is this still happening?

Are you low level or high level? Join https://highlvl.19keys.com/Join 19Keys on 'High Level Conversations', the award-winning show elevating your mindset and value. In Partnership with the Earn Your Leisure network, this is the show where thought leadership meets empowerment. Each episode features luminaries like Billy Carson and Wallstreet Trapper, exploring topics from financial literacy to future tech, emotional intelligence to wellness. Our mission is to challenge, inspire, and ignite change. Be a part of this journey to reshape narratives and elevate consciousness. Dive into our diverse and dynamic content – your platform for growth and cultural empowerment.Unlock the secrets of ancient civilizations and cosmic connections in this must-watch episode of High-Level Conversations!

Send us a Text Message.Ylli  (@brolicgram) clears up the details of the Ashton Bailey (@toobuff4thisss) insanity that is finally being brought to light. The Mateo and Mark are trying to understand things as they happened by interviewing the whistleblower (Ylli). Mark, Ylli, and Mateo are covering a serious topic and exposing this controversy has been quite an experience. Trying to shed light on this topic has generated a lot of misdirection by some and misguided feelings by others and reactions instead of others focusing on the details and acting on putting an end to a dangerous individual with far reach, shameless disregard, and willingness to hurt others.Hosts:Mateo Manko @whitetoe_connoisseur Ylli Mujaj @brolicgramMark Doherty @mark_collaborativestrengthProducer:Producer Bestar Mujaj @beunz

Frame 180 - Your Next Prime Minister. The Mes are back and this time the match determines who will lead this great self-playing, lonely nation. It's some of the best snooker we've ever seen on the old green board, so don't miss it!

On our final minisode between seasons, we are talking about Mass Effect, which we definitely said we would not be covering on the show but now we are because we all ended up playing it anyways to get ready for ME2! So enjoy as we talk about this short romp through space.

On today's P1 podcast, Eddie tells us his story of how he joined the "Me2" movement... and we are here to support him

Frame 179 - CBD. In a crucial frame, Me 1 takes on Me 2 at the sport of snooker and without hyperbole this frame is the greatest sporting event of all time. It may not count in the record books as both players are drug enhanced, but drugs are great and everyone should take them all the time. Anyway see or listen to what happens.

Frame 178 - Ridiculously Late Football Scores. The snooker is back (temporarily) and all involved are too exhausted to do this. They sleepwalk their way through it all making errors galore but creating a thrilling denouement. I'd say don't waste your time, but why else would you be watching?

Frame 177 - Snooker Hole. Whatever Rich thinks, it's Frame 177 and the first of 2024, but who will be the first winner in this final year of human civilization? You're going to have to fight your way through Name That Tune and the football scores to get there. But it's definitely the best frame of this year with surprises in store for everyone.

In which we talk about the middle section of ME2, where we get the band together and do everyone a favor.

“The Nation's Favourite Uncle”, comedy titan Nick Helm, closes our series 1 discussion. A massive collection of Red Dwarf t-shirts! Watching every episode four times a day! Turning the hell of teeth straightening appointments into the heaven of Red Dwarf video shopping! That's all stuff we talk about!From the challenges of making two Rimmers work, to the ruination of a soup, we give “sitcom 2001” series 1 episode 6, Me2, a good going-over. Major questions are posed. Like: what is Lister without Rimmer? And: original intro or electric guitar bonanza, what's best? Listen and learn. SO WHAT IS IT?Better Than Life is the pod where comedians talk Red Dwarf, the greatest sci-fi sitcom, one episode at a time. With a fresh guest every ep, we're your perfect podcast companion for a first watch or a rewatch. Be warned: spoilers! Hosted by Fergus (huge fan) and John (lapsed fan). Production, artwork and insights by Alex Watson. FANCY SOME LINKS?Instagram is Nick's preferred social medium. Follow @thenickhelmSee Nick live on tour in 2024 – grab tickets for his accurately named Super Fun Good Time Show. WHAT DO YOU THINK?Have a word on our socials: X/Instagram/Facebook - @itsBTLpodEMAIL USWe'd love to ask your questions on the pod – and to hear your feedback. Drop us a line: betterthanlifepod@gmail.com ENJOY OUR THEME TUNE?There's more where that came from: https://holygoats.bandcamp.com/album/monsters Hosted on Acast. See acast.com/privacy for more information.

Welcome to HORROR MOVIE PODCAST, where we're Dead Serious About Horror Movies… This episode, 227: The Top 10 Horror Movies of 2023, is the first year end episode of HMP 2.0 and part 1 of a two part year in review series. In this episode Nathan, Victor and Trey are joined by Brian Scott (Horror Movie Fanboy) to give our personal top 10 horror movies of 2023.Keep an ear out for part 2 where we give our honorable mentions and reveal the listener's top 10 (you still have time to submit your list here: https://forms.gle/nc9fEKeZtRmXnLqcA)Enjoy the episode and leave your comments below!Brian's Top 10:1. Thanksgiving2. Infinity Pool3. When Evil Lurks4. Totally Killer5. Hell House LLC: Origins: The Carmichael Manor6. Beau is Afraid7. Dark Harvest8. Talk to Me9. The Wrath of Becky10. It's a Wonderful KnifeTrey's Top 10:1. Godzilla Minus One2. Thanksgiving3. Talk to Me4. When Evil Lurks5. Infinity Pool6. Huesera: The Bone Woman7. Influencer8. The Passenger9. The Wrath of Becky10. ResurrectedVictor's Top 10:1. Talk to Me2. Infinity Pool3. Sick of Myself4. When Evil Lurks5. Godzilla Minus One6. The Pale Blue Eye7. Brooklyn 458. Birth/Rebirth9. Thanksgiving10. Evil Dead RiseNathan's Top 10:1. Godzilla Minus One2. Infinity Pool3. Beau is Afraid4. Moon Garden5. Talk to Me6. When Evil Lurks7. Huesera: The Bone Woman8. Birth/Rebirth9. Thanksgiving10. Satanic HispanicsAlso, please subscribe to our show for free on Apple Podcasts and leave us a review! It really helps our visibility. Or just tell a friend. We'd really appreciate it.Link to the Horror Writers of America interview with Victor Rodriguez: https://vhrodriguez.wordpress.com/2023/10/12/interview-with-hwa/Links:Brian Scott:Twitter: @BrianDarthScottFacebook: Brian Scott Nathan Bartlebaugh:www.phantomgalaxy.podbean.comTwitter: @fantomgalaxyFacebook at: The Phantom Galaxy Podcast Email: Phantomcasts@gmail.com Vicious Victor:Follow me on Twitter or IG so we can talk about horror movies: @dimestorecaesarVisit my website for free-to-read fiction, interviews, and links to my latest short fiction releases: https://vhrodriguez.wordpress.com/Read my first collection THE SOUND OF FEAR: https://a.co/d/14rHPS1Check out my supplementary podcast INSIDE THE SOUND OF FEAR: https://share.transistor.fm/s/b467629cTrey WhetstoneScreaming Through the Ages Podcast - https://screaming-through-the.captivate.fm/Twitter - https://twitter.com/ScreamingAgesFacebook Group - https://m.facebook.com/groups/319316706773860/Jackson Rawlings (Father and Son Watch Horror Movies Podcast)Twitter - @Kaine_Hero12VelocipastorTwitter - @PastorMattRWebsite - https://fatherandsonwatchhorror.com/ Bill Van Veghel:Other places to find Bill:https://www.facebook.com/bvanveghelhttps://letterboxd.com/billhorrorguy/https://landofthecreeps.blogspot.com/

Frame 176 - Victorian Ghost Child. It's a crucial frame in this ongoing contest and maybe the last of 2023. Who will win at snooker? That's the ultimate question. There is an unwelcome visitor and some amazing breaks and so on. Plus big prizes for name that tune. If you watch live.

Frame 175 - Rwanda. In a crucial frame, Me1 faces up to Me 2 to see who is the best at snooker. All the usual features including name that snooker stick tune, puppet predictions, 20.04 football scores, interviews and also some snooker. Incredible action, incredulous commentary, a tired man who should be with his family. What more do you want? Blood?

Frame 174 - Without Prejudice. In a crucial frame Me1 takes on Me2 at snooker. One player has been in the doldrums. Will they turn up today? And if not, how the hell will we play the game with just one player?

Chalky Fingers/Predictive Hand. In a crucial frame Me1 takes on Me2 at snooker. Plus another name that tune with big cash prizes and some astonishing potting. But who will win? And what shall become of the doubters?

It's a crucial frame in the contest, with one player in extraordinarily poor recent form. Can they turn it around? Will Charles III experience the same fate as Charles I and who will be winning the battle of Man versus Boys at 8.03pm. Plus Guess that Tune and Whory Horse guesting as score predictor. And despite the huge number of football fixture, it's the quickest frame ever, so be grateful for small mercies.

Frame 171 - Carrot Based Prediction. In a crucial frame of snooker Me 1 takes on Me2 at snooker to find out who is the best at snooker. But who will it be? (Who is the best at snooker). Plus guess the cue chalk tune, puppet predictascore and the 8.03pm football scores. It's a perfectly acceptable form of entertainment.

Frame 170 - Very Little Sexism. Another thrilling and crucial frame from the old green board, from a time where it looked like York City might be in with a chance of winning a football match. Two very different foes with surprisingly equal statistics take each other on in the greatest sport ever created. Who will win? That's the basic premise. Plus advance news about RHLSTP guests: richardherring.com/rhlstp

The Birdy Song - In a crucial frame Me 1 takes on his opponent Me2 to see who is best at snooker. By the end of the frame we should know who is best for now. But not until death of one or all of the players will the conundrum finally be solved. Plus 8.04 football results. Will it be good news for York City in their bottom of the table clash (spoilers - no).

It's back! That's all you need to know! See RHLSTP on tour: richardherring.com/rhlstp

Caroline Whiddon thought she was going to play French horn professionally, but panic and anxiety had other ideas. Fortunately, orchestra administration turned out to be her true home, ultimately leading her to co-found the Me2/ orchestra with her husband, conductor Ronald Braunstein. Braunstein's bipolar diagnosis left him unable to find work, and Me2/ is the world's only classical music organization created by and for individuals with mental illnesses and the people who support them. Caroline and I talk about the power of music to create change, what happens when you create stigma-free zones, the documentary, Orchestrating Change, that chronicles Me/2's journey, and more. Episode breakdown: [00:04:31] Following someone else's strict sense of music education vs. having a strong inner sense of musical identity. [00:07:36] Panic attacks derail performance career, and lead to orchestra administration instead. [00:16:44] Starting orchestra administration in Savannah. [00:22:49] Conductor Ronald Braunstein decides to start a non-auditioned orchestra for the mentally ill. [00:30:49] Challenging beginnings, slow growth, but incredible progress. [00:35:15] Integration breaks stigma, impacts everyone's lives. [00:41:08] Music for mental health, supporting and educating. [00:48:20] A chance discovery leads to inspiring documentary. [00:51:22] Film documents musician's journey despite challenges. [00:58:43] Signage promotes safe spaces, challenges stigma. [01:02:46] Strategic planning for expansion, focus on accessibility. Please leave a review and in it, tell us about a time when being fully seen made a difference to you. Want more? Here are some handy playlists with all my previous interviews with guests in music. Check out the show notes at fycuriosity.com, and join the conversation on Post.news, Spoutible, and Mastodon! If you'd like weekly updates, plus a chance to see what's going on in my world, check out my new (free!) Substack newsletter.

Frame 167 - It's Only A Game. Me1 and Me2 are both going to be snookering you tonight and you're going to love it. It's a show with everything, a song, a virtuoso playing their instrument, a hippopotamus obsessed with mammary glands. More than 3 two ball breaks. And the beautiful moment when Luton Town weren't going to be in the play off finals. Plus it's a crucial frame.

Frame 166 - Monarchy vs Republic. In this crucial frame of snooker, not only do we get to find out which Me is best at snooker this week, but also resolve how the UK will be governed for the next 1000 years. Plus Rich thinks he might be drinking real gin and loses his mind and gives you some 40 year old mnemonics and vocab songs from his o level studies and plays his snooker stick along with another classic comedy song. Was he drunk though? Nope, he checked. It was non-alcoholic gin. What a lightweight. Some good snooker though and hopefully you will know your place after this.

Frame 165 Simon Tutu - In a crucial frame tonight, Me 1 tries to defeat Me2 at snooker whilst Me2 in turn attempts to defeat Me1. But who will do the dirty business? Sybil has had a makeover and Richard is playing his cue like a Stradivarius and singing about Woolworths. More importantly it's an incredible standard of snooker for you to enjoy. So do that or this is all for nought.

The 3 big leads:1. I have to lead ME2. I have to lead MY HOUSE3. I have to lead to JESUSPastor Drew Griffin continues our sermon series "As For Me and My House."

Frame 164 - Orange. In a crucial frame Me1 takes on Me2 at snooker. I hope nobody protests. Not that that would make the board any more unplayable. Who will win? Me or me? The only loser is you, for wasting your time on this.

Write It Down! After a holiday break (geddit?) Me1 and Me2 are back for a crucial frame in the tournament which could have a huge impact on the final result. Richard seems distracted by half-remembered comedians and is incredibly still not over his recent bug, but the players, whilst shit, provide a thrilling match with incident and balls and a cat in it.

Frame 162 - Don Quixote. The snooker is back and so are the all important voices of the host and the commentators (well one of them). It's another crucial frame, but the cat litter box is proving a worthy adversary and the players aren't very good at snooker. Still it only ends with death.

"Maybe you're right. Maybe we can't win this. But we'll fight you regardless, just like we did Sovereign. Just like I'm doing now. However "insignificant" we might be, we will fight, we will sacrifice and we will find a way. That's what humans do." -Commander Shepard. And so begins our journey into one of the best sci-fi western RPGs ever made: Mass Effect 2Kevin and Ethan of Project XTalk: An Xbox Podcast join me to talk about their show and their method in getting this massive project up and off the ground. They're multifaceted and bring some fresh perspectives into content creation I think everyone should check out. They run shows that cover Xbox, Playstation, Movies/TV and even a friendly banter show Nick is a huge fan of. I'm really happy they chose to jump on the show to discuss ME2 and we had so much fun reliving our experiences as Commander Shephard. Jump in with us to finish the fight!(00:30) - Intro(01:20)- Interview with the Kevin and Ethan of Project XTalk & Save The Game Media(01:07:15) - Mass Effect 2 Review(02:12:11) - OutroKevin and Ethan truly were fantastic guests to have on and as some of the primary members of Save The Game Media, they're working hard to bring all their fans as much content as quickly as possible. Make sure to go check out their link below if you don't want a Collector incursion to decimate your surrounding area. They have a team they can bring together!https://linktr.ee/SaveTheGameMediaIntermission/Game Music: Mass Effect 2 OST [Composed by: Christopher Lennertz, Chris Velasco & EA Games Soundtrack team]Mix & Mastered by: Daniel Campolihttps://www.danielcampoli.com/portfolioExtra special shout out to Dan this episode for really helping me a lot with this sound mix.If you want to reach out to Nick and Will personally to engage with us about the show, follow us on any link here:https://linktr.ee/FridayNightGamecastSupport the show

Frame 161 - Strike. Nazi supporter Ian Twitch has suspended Richard Herring for offending him by saying that the Tories are the same as the Nazis. Consequently all the pundits, commentators and predicting puppets have gone on strike in support. So this is a bare bones edition of the contest, with just the action. Which means it has all the pots in, no "expert" analysis and will probably be quite hard to follow in audio only. But unless you are a scab you will still listen. Some great action. Just a shame we couldn't describe it. On the plus side, it is mercifully brief.

Frame 160 - Winner Gets Ants. All the usual rubbish from this long running snooker competition, plus all the excitement of the FA and Scotch Women's football. And also some snooker. It's a very exciting frame. But can some puppets predict the result? I used to be on TV.

Frame 159 - Potting through the Pain. It's another round of snooker and both players have been poked in the eye and also have painful hips. But that doesn't stop them playing snooker to a scarcely adequate standard. Who will win? They thought it was all over, but is it now?

Framer 158: Sh!thouse - An absolutely appalling game of snooker to follow last week's classic. Nothing in this is worth your time or your money. Luckily we are not asking for money, but you could potentially earn some money by doing something productive instead of experiencing this. There was a good shot near the end and also a great escape from an impossible snooker, though you can't see it properly because the logo was in the way. Back for more next week.

Frame 157 - Academical. It's the first frame of 2023 and what new year's resolutions will the players have and will anyone involved remember how any of this works? It doesn't matter. It's one of the greatest displays of self-playing snooker ever recorded. Sit back and enjoy it all, because sport does not get better than this.

Frame 156 - Politics and Sport. In a crucial frame Me1 takes on Me2 - one of them is on a bad run of form, can he turn it around? And will there be any repercussions for Referee 1 after last week's controversies. And will the LGBTQ+ community boycott the sport after this week. Find out by watching/listening to the latest instalment in this thrilling contest.

I am the very model of a sci-fi shooter RPG! From Omega to Luna I'm the zenith and the apogee! 2010's Mass Effect 2 continues the story of Commander Shepard's quest to save the galaxy, but with new crew members, new benefactors, and way more planet scanning. An RPGFan away team discusses Mass Effect 2's villains-turned-allies, new alien cultures, and daring final mission in today's episode of Retro Encounter! Featuring: Michael Sollosi, Wes Iliff, Jonathan Logan; Edited by Anthony KrolikowskiOpening and ending music by Miles MorkriGet in Touch:RPGFan.comRPGFan ShopEmail us: retro@rpgfan.comTwitter: @rpgfancomInstagram: @rpgfancomFacebook: rpgfancomTwitch: rpgfancomRelated Links:Mass Effect 2 on RPGFan

Frame 155 - Touching the Pink. It's a crucial frame and there's a couple of controversial moments that could alter the whole course of the competition, but the referee's decision is final. Plus a 7 year-old heckles as she insists we look at her art, the football scores are in at 8.03 and Prince Andrew is back. I remember when this thing was purely about the sport of kings, self-playing snooker, not the sport of noncy dukes. No Sweat. Enjoy it now before unlucrative ads ruin it.

Today we discuss our first spoiler-free impressions on God of War Ragnarok, we discuss our top Ultra Rare trophies, The Perceiver, Project Cars & Dirt get canceled, N7 Day happened and how we need to get our ME2 episode out. Plus so much more!  For first time visitors: We appreciate you stopping by. For returning visitors; Welcome back! We are a dedicated Weekly PlayStation Podcast called: PS This is Awesome! A PlayStation Podcast. You can stream our Podcast on your preferred podcasting service or just tune in and watch the show on YouTube!  Please, if you enjoyed the content or even if you didn't quite enjoy this one, we encourage you to come back. We try to offer something for everybody. Please share with your friends and help us spread the show as we try to build a bigger community here!  As always you can support our show at our Patreon Page. Thanks for listening. http://www.patreon.com/psthisisawesome 0:00 - INTRO13:07 - LISTENER FEEDBACK15:10 - PS PLUS GAME OF THE MONTH16:14 - OUR ULTRA RARE TROPHIES36:05 - GOD OF WAR RAGNAROK (GAMES WE'RE PLAYING)49:32 - GAMES GETTING SPOILED ON PLAYSTATION CONSOLES54:20 - CONTROL 2 IS CONFIRMED58:10 - DRAGON AGE: ABSOLUTION1:00:55 - THE PERCEIVER1:05:04 - GOD OF WAR COLLECTOR'S EDITION DOWNLOAD CODE ISSUES1:15:45 - KFC ADVERTISING HIT THE MARK1:18:05 - TLOU GETTING A BOARD GAME1:25:50 - PROJECT CARS & DIRT ARE CANCELED1:27:00 - N7 MASS EFFECT DAY1:30:30 - CLOSING Support PS This is Awesome! Hosted on Acast. See acast.com/privacy for more information.

Frame 154 - Nonce Sense. In a crucial frame Me 1 and Me 2 battle it out for the title of who is the best at snooker. There's arena naming controversy and Sybil is unavailable, but surely no one else is capable of seeing the future like her? It's a high octane contest and maybe the best snooker we've seen on the old green board since lockdown.

Frame 153 - Vision On. In a crucial frame Me1 takes on Me2 at snooker and to couldn't be more exciting. It's just not possible. Even if it was on a rollercoaster. In many ways that would spoil it.

Frame 152 Snooker, She Wrote - In a crucial frame in the contest Me1 takes on Me2 at snooker with hilarious consequences. Plus football scores at far too far into the matches to be of any interest to anyone.

Frame #151 Stone of Scoooooooon. In a crucial frame Me1 takes on Me2 as they attempt to ascertain who is the best at snooker. Plus news of the most important football match of the year, Halifax Town versus York City. And a scary doll.

In Liz We Truss. It's a century and a half of snooker in just ten and a bit short years and tonight is a pivotal frame in the contest. Crucial some might say. Some amazing snooker but from whom and for how long. Will defeat be snatched from the jaws of victory again. And who will buy Richard's book?

Frame 149 - Executioner. The period of mourning is over but one player is still reeling from the funeral, whilst the other expresses views on the monarchy that can not be condoned by any right thinking person. But away from politics and football scores it's a thrilling and crucial frame. Enjoy the action.