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durée : 01:18:28 - Les Nuits de France Culture - par : Antoine Dhulster - En 1994, pour "Les Nuits magnétiques", Simon Guibert demandait à des Européens ce que l'Europe représentait pour eux. - réalisation : Virginie Mourthé
Le Retour du Vrai Chevrolet Blazer ? | POURQUOI PAS !?TORQ PODCAST - Épisode 389
Méga Rappel GM : Le Problème des Moteurs V8 6.2L Révélé ! TORQ PODCAST - Épisode 386Jul Torq décortique le vaste rappel émis par General Motors touchant un problème potentiellement sérieux sur certains de leurs moteurs V8 6.2L. Découvrez les détails techniques du problème, les modèles de véhicules concernés (Camions, VUS?), et les démarches à suivre si vous êtes propriétaire d'un véhicule affecté.Restez informés pour votre sécurité et celle des autres !YOUTUBE Membres VIP :https://www.youtube.com/channel/UCbha0iHrKImRyDXbDNO-EJw/joinSpotify Membres VIP :https://podcasters.spotify.com/pod/show/torqpodcast/subscribeTORQ MEDIASite Web : https://torqmedia.ca FAST WHEELS https://fastco.ca/Fast-Wheels/HomeONEBONE Site Web : https://onebonebrand.com/jultorqCode : JULTORQ ( - 15% Rabais )Suivez-Nous sur Instagram :@JulTorq : https://www.instagram.com/jultorq/@EveTorq : https://www.instagram.com/evetorq/#Moteur #ChevroletSilverado #GMCsierra
À l'occasion de sa revue de presse, lundi, Paul Arcand fait le point sur l'attaque au camion-bélier à Vancouver. La communauté philippine s’était rassemblée pour célébrer le festival Lapu Lapu, samedi soir, lorsqu’un conducteur à bord d’un VUS a foncé dans la foule. Le bilan : au moins 11 morts et une vingtaine de blessés. Le suspect fait face à des accusations de meurtre au deuxième degré. Mais pourquoi a-t-il commis un tel geste? «Il y a pas de motifs en tant que tels, indique Paul Arcand. Il n'avait pas de griefs contre la communauté [...] La police a dit que ce n'est pas un acte terroriste, c'est plutôt quelqu'un qu'on connaît qui a des problèmes de santé mentale. La police est intervenue à plusieurs reprises chez lui. Ça a été confirmé.» Autres sujets abordés Jour de vote: les bureaux de scrutin sont ouverts de 9h à 21h30; La mafia et les Hells auraient décidé de faire la paix; Après s'être effondrés en troisième période, les Canadiens de Montréal s'inclinent face aux Capitals de Washington, qui mènent maintenant la série 3 à 1. Voir https://www.cogecomedia.com/vie-privee pour notre politique de vie privée
Cadillac Escalade 2025 : Trop cher pour ce que c'est ? Mon verdictEssai Complet : Cadillac Escalade Platinum Sport 4x4 2025 TORQ PODCAST - Épisode 383Le LUXE Ultime à quel PRIX ?
Vus de Washington et Moscou, Ukrainiens et Européens sont des empêcheurs de faire la paix entre soi.Hébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.
Nouveautés Kia : Découvrez la EV4, la K4 Hatchback et la EV9 Nightfall Edition !TORQ PODCAST - Épisode 380KIA EV4, K4 HATCHBACK & EV9 NIGHTFALL : Notre analyse des NOUVEAUTÉS dévoilées à New York !
Ford Everest : Pourquoi n'est-il pas disponible en Amérique du Nord ?TORQ PODCAST - Épisode 376Ford Everest : Qu'est-ce que c'est et pourquoi il est absent d'Amérique du Nord ? Jul Torq explore les caractéristiques de ce VUS robuste et les raisons de sa non-disponibilité en Amérique du Nord. YOUTUBE Membres VIP :https://www.youtube.com/channel/UCbha0iHrKImRyDXbDNO-EJw/joinSpotify Membres VIP :https://podcasters.spotify.com/pod/show/torqpodcast/subscribeTORQ MEDIASite Web : https://torqmedia.ca FAST WHEELS https://fastco.ca/Fast-Wheels/HomeONEBONE Site Web : https://onebonebrand.com/jultorqCode : JULTORQ ( - 15% Rabais )Suivez-Nous sur Instagram :@JulTorq : https://www.instagram.com/jultorq/@EveTorq : https://www.instagram.com/evetorq/#FordEverest #VUS #FordRanger
L'Ensemble vocal de Lausanne chanta ovras sacralas contemporanas d'ina cumponista svizra e da cumponists svizzers. In mument da reflexiun, in ensemble vocal, in'orgla, ina baselgia. Schebain ch'il context lascha supponer in concert da musica veglia, vegnis Vus ad esser surprais agreablamain, sche Vus scuvris la lingua musicala d'ina cumponista svizra e da quests cumponists svizzers dal 20avel e 21avel tschientaner. RTS ha registrà il concert da l'Ensemble vocal de Lausanne dal mars 2024 en la baselgia Saint-Gervais a Genevra.
Il s’est vendu un nombre record de voitures neuves au Québec l’an dernier. Le Québec domine le reste des provinces en nombre d'achats de véhicules électriques, bien que les VUS restent un choix populaire. Écoutez la chronique financière de Clémence Pavic, qui discute notamment des achats d'automobiles.Voir https://www.cogecomedia.com/vie-privee pour notre politique de vie privée
The Katherine Massey Book Club @ The C.O.W.S. hosts the 3rd study session on the late Dr. Maya Angelou's A Song Flung Up To Heaven. This is the 6th autobiography in her 7 book memoir series. We read books 1, I Know Why The Caged Bird Sings, and 4, The Heart of a Woman. Dr. Angelou now reigns as the only author to have three books read on the Katherine Massey Book Club. We're reading this book to hear Dr. Angelou's depiction of the assassinations of Minister Malcolm X and Dr. Martin Luther King Jr. Last week, Dr. Angelou detailed the smells and sounds from her sightseeing tours through the 1965 Watts riots. Oddly, she laments the lack of attention she receives while everyone is focused on the smoldering ruins and shootin' and lootin'. With a reputation as a poet, not a historian, Dr. Angelou is scant on specific details about what's happening during the infamous SoCal battle. The late Wanda Coleman wrote that a few of Dr. Angelou's descriptions of the Watts kerfuffle are factually incorrect. Later, the Wake Forest scholar tells us that she and her "former husband" Vus, who is not named in this book, attempt to reconcile. It fails miserably, and they resume the same toxic, destructive arguments they had on a different continent. We noted that the daily consumption of alcoholic beverages is a theme in both Dr. Angelou memoirs we read this year. Including the infamous Mogen David's "Mad Dog 20/20" - which is a fortified wine that's been banned in parts of Seattle, Washington. #SobrietytWouldBeBest #TheCOWS16Years INVEST in The COWS – http://paypal.me/TheCOWS Cash App: https://cash.app/$TheCOWS CALL IN NUMBER: 605.313.5164 CODE: 564943#
durée : 00:03:19 - Le Billet de Daniel Morin - par : Daniel Morin - Ca fait cher pour un téléphone pas cher, non ?
durée : 00:03:19 - Le Billet de Daniel Morin - par : Daniel Morin - Ca fait cher pour un téléphone pas cher, non ?
The Katherine Massey Book Club @ The C.O.W.S. hosts the 8th and final study session on the late Dr. Maya Angelou's The Heart of A Woman. The acclaimed author, poet, rape victim and Victim of White Supremacy, Dr. Angelou penned a 7-book autobiography series on her life and work. This is book number 4 in the series. Gus T. was inundated with the life and literary work of Dr. Angelou during his recent Golden State sojourn. And it took Gus seeing the documentary film Soundtrack to a Coup d'État three times to accurately write down the title The Heart of a Woman. The extraordinary film on the assassination of Patrice Lumumba is "receipt-heavy," and Andrée Blouin and Dr. Angelou's respective memoirs are just 2 of the many books in the project. Last week, Dr. Angelou describes following her husband Vus to Africa without even an address or hotel reservation once she travels across the planet with her son, Guy. She and Vus have repeated conflicts about money and are nearing a second eviction. Dr. Angelou tells us she fell out of "love" with her care mate at this point. We heard about a lot more parties, dancing and liquor drinking. Dr. Angelou took time to make a distinction between she and the black people born in the United States as opposed to black people born in Africa. She incorrectly tells readers that "black Americans" were the last large group of people enslaved on the planet. Brazil kept black people in formal slavery until 1888, and there are millions more black people in the Portuguese-speaking country than the US. #ImGoinGetMeSomeStuffTonight #SoundtrackToACoupdÉtat #TheCOWS16Years INVEST in The COWS – http://paypal.me/TheCOWS Cash App: https://cash.app/$TheCOWS CALL IN NUMBER: 605.313.5164 CODE: 564943#
Between 5-10% of breast and 20-25% of ovarian cancers are inherited. The majority of hereditary breast and ovarian cancer cases are caused by deleterious mutations (variants) in the BRCA1 and BRCA2 genes, which normally prevent cancer through protecting and repairing our DNA. Genetic testing is used to identify pathogenic BRCA carriers who would subsequently benefit from personalized screening, preventative and management plans. However, its widespread implementation has resulted in a significant increase in findings of variants of uncertain significance (VUS) – DNA sequence variants with uncertain effects on disease risk. VUSs pose a critical clinical challenge as they limit clinicians' ability to effectively interpret genetic test results. For upcoming interviews check out the Grad Chat webpage on Queen’s University School of Graduate Studies & Postdoctoral Affairs website.
The Katherine Massey Book Club @ The C.O.W.S. hosts the 7th study session on the late Dr. Maya Angelou's The Heart of A Woman. This is a rare "double dip" for the book club, as we read I Know Why The Caged Bird Sings in the summer of 2014 just after the transition of the famed author and Wake Forest scholar. Gus T. was inundated with the life and literary work of Dr. Angelou during his recent Golden State sojourn. And it took Gus seeing the documentary film Soundtrack to a Coup d'État three times to accurately write down the title Heart of a Woman. The extraordinary film on the assassination of Patrice Lumumba is "receipt-heavy," and Andrée Blouin and Dr. Angelou's respective memoirs are just 2 of the many books in the project. Last week, Dr. Angelou describes her involvement in the White French convict Jean Genet's play, The Blacks: A Clown Show. This celebrated show featured a cast of renown black thespians and was shown around the world. Dr. Angelou describes how mostly White audiences devoured the play, but continued their dedication to White Supremacy - even to the negro cast as soon as they stepped off the stage. The Suspected Racist director, Sidney Bernstein, shafted Max Roach and Dr. Angelou for their musical labor on the play. This is typical White Racism and the time-honored White tradition of robbing black artists. Bernstein was not ignorant about Racism. After speculating that her husband Vus might be cheating on her, our heroine contemplates poisoning her African care-mate. #AppleEvent #SoundtrackToACoupdÉtat #TheCOWS16Years INVEST in The COWS – http://paypal.me/TheCOWS Cash App: https://cash.app/$TheCOWS CALL IN NUMBER: 605.313.5164 CODE: 564943#
Acura MDX Type S Est-il Toujours au Sommet ? - Essai Complet Essai Routier : Acura MDX Type S Ultra 2025 TORQ PODCAST - Épisode 328 Acura MDX Type S : Le VUS idéal pour la famille et les amateurs de conduite sportive ? Jul Torq passe en revue les aspects pratiques du MDX Type S : espace intérieur, technologie embarquée, sécurité et confort pour les passagers. Mais est-ce que ce VUS peut aussi nous faire vibrer sur route sinueuse ? YOUTUBE Membres VIP : https://www.youtube.com/channel/UCbha0iHrKImRyDXbDNO-EJw/join Spotify Membres VIP : https://podcasters.spotify.com/pod/show/torqpodcast/subscribe TORQ MEDIA Site Web : https://torqmedia.ca FAST WHEELS https://fastco.ca/Fast-Wheels/Home ONEBONE Site Web : https://onebonebrand.com/jultorq Code : JULTORQ ( - 15% Rabais ) Suivez-Nous sur Instagram : @JulTorq : https://www.instagram.com/jultorq/ @EveTorq : https://www.instagram.com/evetorq/ #AcuraMDX #TypeS #LuxurySUV
En questa «Marella» survegnis Vus in'invista en la lavur d'ina giuvna magistra – e quai cun tut las sfidas e tut ils plaschairs che tutgan tar questa professiun. I va per ils egls dals uffants che traglischan, cura ch'els han chapì insatge fin a las uras stentusas cun la lavur administrativa. Anna Cathomen, la giuvna magistra primara che mussa ses mintgadi, raquinta era da l'integraziun e da sia atgna scolaziun. La fin finala resta la dumonda: è esser magistra ina lavur da siemi u il cuntrari?
Après avoir mangé de la dinde pas cuisinée par Maïté, l'équipe de J+7 attaque cette nouvelle année rassasiée de programmes Vus et Entendus ; à commencer par le retour gagnant du Bigdil, qui n'aura même pas l'occasion d'affronter Petit-Tonnerre, Pépito et Caramel, les Gladiateurs de TF1 qui se sont ramassés en beauté. Pas de Bravo d'or pour eux donc, ni pour pour les Bravo d'Or qui rate son dépoussiérage du genre. Pour continuer ce tour d'horizon, Arnaud et Gautier feront part de leurs hauts potentiels intellectuels grâce au Grand Test QI d'M6. Enfin, le Monde Magique de Commandeur déchaînera les passions. Dans l'actu, France Bleu se tire ailleurs mais reste Ici, Camille Combal rempile sur NRJ mais repousse sa rentrée, une pause de Popcorn pour Domingo qui reviendra en mars (après Mask Singer ????). Enfin, l'équipe terminera par un hommage à Catherine Chaillet et Benoît Allemane. Et pêle-mêle, le pêle-mêle de Gautier mais aussi Jean-Michel Empathie, 100% physique, les muscles sont sous vos yeux, un peu de littérarthur pour clore le chapeau, Arielmaleh, Ici les cadres bleus et RTL2 08.36.65.65.65. Au sommaire : 0:00 - Introduction 11:18 - Vu & Entendu - Le Bigdil 51:49 - Vu & Entendu 1:43:29 - L'Actu 2:22:23 - Conclu Source : X - Maxime Gueny - Courbe d'Audience du Bigdil X - Julien Lalande - Audience du Bigdil Le Parisien - Lagaf' réagit au carton d'audience du retour du « Bigdil » sur RMC Story : « Ils ont fait confiance au vieux » Le Parisien - « L'émission est vraiment nulle » : comment TF1 a débranché son nouveau jeu « Gladiators » en catastrophe Le Parisien - Audiences TV : Catastrophe pour « Gladiators » sur TF 1 Le Parisien - « On n'est pas dans les polémiques » : « Les Bravos d'or » de Nagui récompensent les plus gros succès de 2024 Puremédias - Audiences : Lorie et France 3 larges leaders, catastrophe pour la première édition des “Bravos d'or”, qui ne dépasse pas le million de téléspectateurs sur France 2 Le Parisien - Audiences : “Panique au 31” et Arnaud Ducret cartonnent sur TF1, Jean Dujardin en “Zorro” s'effondre sur France 2 ici - France Bleu change de nom et devient “ici” X - Kevin Boucher-Rappet - Camille Combal Youtube - Popcorn - à bientôt. Youtube - Domingo - Quelques explications concernant la grosse annonce Popcorn ! L'Informé - Webedia (Allociné, PurePeople, Jeuxvidéo.com…) à la peine, départ surprise de son DG Lenodal.com - Décès de Catherine Chaillet X - Radioscope - Décès de Benoît Allemane Recommandation : Dans L'Ombre Des Médias - Les coulisses du Bigdil - Dans la peau de Bill (ITW Gilles VAUTIER) Rejoignez le Discord d'Alex Arbey, suivez @jplussept sur X/Twitter et sur Instagram ou @jplus7.fr sur Bluesky Laissez-nous vos avis sur ce que vous avez vous aussi vu & entendu tout au long de la semaine sur repondeur.jplus7.fr Une émission animée par Alex Arbey, en direct sur Twitch tous les lundi à 20h35 : twitch.tv/alexarbey
Today, we’re going to talk to Carmen David, who is going to share her experience with an aortic dissection after the delivery of her second daughter, her experiences recovering from that physically and emotionally, how she handled the information of two VUS’s, or Variants of Unknown Significance, and what she’s been doing since her dissection … Read More Read More
Volkswagen Atlas Peak Edition 2025: Un Look Hors-Route sans les Capacités? Essai Routier : Volkswagen Atlas Peak Edition 2025 TORQ PODCAST - Épisode 304 Dans cet épisode du Torq Podcast, Jul Torq se penche sur le Volkswagen Atlas Peak Edition 2025, un VUS qui promet de concilier style aventurier et confort. Mais ce modèle a-t-il les capacités pour affronter les chemins les plus difficiles ? Nous mettons à l'épreuve ce SUV sur différents terrains pour évaluer ses performances en tout-terrain. Conception, motorisation, confort : nous passons en revue tous les aspects de ce véhicule. YOUTUBE Membres VIP : https://www.youtube.com/channel/UCbha0iHrKImRyDXbDNO-EJw/join Spotify Membres VIP : https://podcasters.spotify.com/pod/show/torqpodcast/subscribe Torq Media Site Web : https://torqmedia.ca ONEBONE Site Web : https://onebonebrand.com/jultorq Code : JULTORQ ( - 15% Rabais ) Suivez-Nous sur Instagram : @JulTorq : https://www.instagram.com/jultorq/ @EveTorq : https://www.instagram.com/evetorq/ #VW #VwAtlas #PeakEdition
The Czech Terminator is back In this episode I am joined again by Vusyk We catch up, discuss all the amazing stuff that's happened since we last talked The titles The matches and oh my... What matches His two fights against Sam Gradwell The two MOTY Contenders against Nathan Cruz The fans reaction when he saw sense and laid out Sash Working with Leon Slater That moment with Spike Trivet Teaming with Ian Skinner and so much more Hope you enjoy watching this as much as I did recording it Not even three years into his Journey and Vus is just.. unreal
INFINITI QX80 : Toujours dans l'ombre des VUS de grande taille Américain ? Essai Routier : Infiniti QX80 Autograph 2025 TORQ PODCAST - Épisode 290 Infiniti QX80 2025 : Peut-il détrôner les géants américains ? Jul Torq met à l'épreuve le nouveau QX80 dans un essai routier complet. Confort, puissance, technologie : on fait le tour de ce VUS de luxe. YOUTUBE Membres VIP : https://www.youtube.com/channel/UCbha0iHrKImRyDXbDNO-EJw/join Spotify Membres VIP : https://podcasters.spotify.com/pod/show/torqpodcast/subscribe Torq Media Site Web : https://torqmedia.ca ONEBONE Site Web : https://onebonebrand.com/jultorq Code : JULTORQ ( - 15% Rabais ) Suivez-Nous sur Instagram : @JulTorq : https://www.instagram.com/jultorq/ @EveTorq : https://www.instagram.com/evetorq/ #Escalade #InfinitiQX80 #Navigator
Le retour du légendaire Scout : Une renaissance électrique ! TORQ PODCAST - Épisode 279 La marque Scout, célèbre pour ses 4x4 robustes, fait un retour triomphal avec une gamme entièrement électrique. Jul Torq vous présente les versions VUS et pick-up. Design inspiré des modèles originaux, technologies de pointe, performances off-road... Découvrez tous les atouts de ces véhicules électriques qui promettent de révolutionner le monde du 4x4. Youtube Membres VIP : https://www.youtube.com/channel/UCbha0iHrKImRyDXbDNO-EJw/join Spotify Membres VIP : https://podcasters.spotify.com/pod/show/torqpodcast/subscribe ONEBONE Site Web : https://onebonebrand.com/jultorq Code : JULTORQ ( - 15% Rabais ) Torq Media Site Web : https://torqmedia.ca Suivez-Nous sur Instagram : @JulTorq : https://www.instagram.com/jultorq/ @EveTorq : https://www.instagram.com/evetorq/ #Scout #ScoutPickup #SUV
Pour la première fois, le karaoké sera disponible pour les propriétaires de Ford, en commençant par le F-150 Lightning et en poursuivant avec le Mustang Mach-E. Les propriétaires, leurs amis et leur famille peuvent profiter du karaoké, grâce à l'application Stingray Karaoke, directement à partir de l'écran du véhicule. Nous en discutons avec Alexandre Benoit de chez Stingray. En essai routier le plus petit VUS électrique de Volvo, le EX30 et la version 2025 du Ford Explorer. Voir https://www.cogecomedia.com/vie-privee pour notre politique de vie privée
Questa dumengia è il final da la concurrenza da chors europeica «Let the Peoples Sing», ina concurrenza da l'EBU chins pudess er titular sco l'ESC dals chors. Ensemen cun trais ulteriurs chors da l'Europa cumbatta l'ensemble vocal incantanti cun ses dirigent Christian Klucker per il premi «Silver Rose Bowl». Mintga chor chanta ses program en ses agen pajais e l'EBU collia ils lieus via las lingias da radio. Davent da las 18:30 pudais Vus tadlar la concurrenza en il radio. RTR emetta las producziuns da concurrenza directamain or da la baselgia S. Placi a Surrein.
Wenn plötzlich alle Grosseltern werden Therese hat sich auf unseren Aufruf hin bei uns gemeldet. Wir wollten Geschichten hören von Menschen, die die Lebensmitte bereits hinter sich haben. Denn wir fragen uns: Wie ist es, kinderfrei zu sein, wenn rund um einen nun alle Grosseltern werden? Welche Déjà-Vus kommen da allenfalls wieder hoch, aus einer […]
Wenn plötzlich alle Grosseltern werden Therese hat sich auf unseren Aufruf hin bei uns gemeldet. Wir wollten Geschichten hören von Menschen, die die Lebensmitte bereits hinter sich haben. Denn wir fragen uns: Wie ist es, kinderfrei zu sein, wenn rund um einen nun alle Grosseltern werden? Welche Déjà-Vus kommen da allenfalls wieder hoch, aus einer […]***** Hat dir diese Folge gefallen? Dann kommentiere sie und abonniere den Podcast überall dort, wo du Podcasts hörst: Apple, Spotify, Deezer, Pocket Cast und Youtube. Du findest uns auch auf Facebook und Instragram. Ein «Like» freut uns ungemein und hilft anderen, «Expectations – geplant und ungeplant kinderfrei» besser zu finden. Gemeinsam mit dir machen wir die leisen Geschichten lauter und machen so den kinderfreien Alltag sichtbar! Expectations bricht Tabus, klärt auf und interviewt geplant und ungeplant Kinderfreie und Expert:innen. Offen und inklusiv, gesellschaftspolitisch relevant. *****
L'aua: in element che dat vita. Ina tscherna da chanzuns che raquintan da plievgia, flums, lais e mar emplaina quest'emissiun da «Noss chors». Esser sper il Rom en Val Müstair, chaminar sut la plievgia u giudair ina saira tar la mar. Quai ed anc bler auter pudais Vus far durant quest'emissiun. Differents chors maschadads e chors virils chantan chanzuns che raquintan da l'aua en sias differentas furmas.
In this episode we’re going to talk to Nancy Billon, who was diagnosed with Vascular Ehlers-Danlos Syndrome (VEDS) with a combination of her medical history and a genetic test that revealed a VUS on COL3A1.
Erin Langley was tested for VEDS (Vascular Ehlers-Danlos Syndrome) due to some concerning family history, but her results came back as a Variant of Unknown/Uncertain Significance, or VUS. In this episode, she shares her experience with those results and how she’s found support in the meantime. Link to the articles mentioned in the interview: The … Read More Read More
Ms. Charité Ricker, MS, CGC and Dr. Nadine Tung, MD, FASCO share updates from the new ASCO guideline on selection of germline genetic testing panels in patients with cancer. They discuss highlights on family history collection, when and how multigene panel germline genetic testing should be used, which genes are generally recommended for testing, and how germline genetic testing interfaces with somatic genetic testing. Ms. Ricker and Dr. Tung also note the importance of the guideline and the impact of these new recommendations on clinicians and patients with cancer. Read the full guideline, “Selection of Germline Genetic Testing Panels in Patients with Cancer: ASCO Guideline” at www.asco.org/molecular-testing-and-biomarkers-guidelines. TRANSCRIPT GDL 24E13 This guideline, clinical tools, and resources are available at www.asco.org/molecular-testing-and-biomarkers-guidelines. Read the full text of the guideline and review authors' disclosures of potential conflicts of interest in the Journal of Clinical Oncology, https://ascopubs.org/doi/10.1200/JCO.24.00662 Brittany Harvey: Hello and welcome to the ASCO Guidelines Podcast, one of ASCO's podcasts delivering timely information to keep you up to date on the latest changes, challenges and advances in oncology. You can find all the shows, including this one at asco.org/podcasts My name is Brittany Harvey, and today I'm interviewing Dr. Nadine Tung, a medical oncologist from Beth Israel Deaconess Medical Center in Boston, and Ms. Charité Ricker, a cancer genetic counselor with the Norris Comprehensive Cancer Center at the University of Southern California and Los Angeles General Medical Center, co-chairs on, “Selection of Germline Genetic Testing Panels in Patients with Cancer: ASCO Guideline.” Thank you for being here, Ms. Ricker and Dr. Tung. Dr. Nadine Tung: Pleasure. Ms. Charité Ricker: Thank you. Brittany Harvey: Then, before we discuss this guideline, I'd like to note that ASCO takes great care in the development of its guidelines and ensuring that the ASCO conflict of interest policy is followed for each guideline. The disclosures of potential conflicts of interest for the guideline panel, including Dr. Tung and Ms. Ricker, who have joined us here today, are available online with the publication of the guideline in the Journal of Clinical Oncology, which is linked in the show notes. So then, to start us off first, Dr. Tung, could you provide us a broad overview of both the purpose and scope of this guideline? Dr. Nadine Tung: Sure. A main impetus for creating the guideline is that oncologists are increasingly being tasked with ordering genetic testing for hereditary cancer risk for their cancer patients. More and more now, they may find themselves sending the test and then seeking guidance from genetic experts to interpret the result. And these panels range from focused tests with just a few genes to comprehensive ones that include over 100 genes. So it can be very overwhelming for an oncologist to be able to understand ordering these tests and explaining them to their patients. So, we believe that it was important to offer some guidance and direction on the use of these multigene panels. Brittany Harvey: Thank you for setting the stage for this guideline and the recommendations that come from it. So then, Ms. Ricker, this guideline addresses four overarching clinical questions. I'd like to review the recommendations based on each of those questions for our listeners. So starting with that first question, what is the importance of family history collection in the setting of germline multigene panel testing and which elements of family history are the most important? Ms. Charité Ricker: Thanks. As a genetic counselor, this is probably one of my favorite questions. I love the opportunity we have to sit with families and really dig into family history. But family history collection can be overwhelming and a big lift sometimes in busy clinics where genetics is not the focus. So, what we tried to do was to break down the key elements of what components of family history are most relevant to informing which test to do, and also the interpretation of those test results. And I like to think about the key pieces of family history as being the who, what, and when of somebody's family cancer history. Who was diagnosed with cancer within their close relatives? And usually we're most focused on first and second degree relatives. So parents, siblings, grandparents, aunts, and uncles. But sometimes relevant history might go into third degree relatives like cousins or more distant. So the who being who has cancer on both sides of the family? And then the what: what kind of cancer was it? Or where did that cancer begin? And the when: how old was that individual at the time they were diagnosed? Often we ask patients maybe not to fixate on the exact age, but to give us a sense. So was this somebody who was diagnosed young, in their 20s or 30s or older, in their 60s or 70s? Because that at least gives us a ballpark around what might be relevant for understanding the genes that should be included on somebody's test. When we are thinking about the purpose of this history, as Dr. Tung said, often the range of multigene panels might be from a few very focused genes to a very broad panel. Family history can help us understand if we need to step beyond the very focused genes that might be relevant for the patient's history of cancer and include other genes that might be indicated based on that family history. So I think about the role that family history has at the time of identifying which test to do and then its role when interpreting what those results mean for the patient and their family. Again, Dr. Tung touched on the fact that we are often testing very large panels. However, we still don't know everything. And so a negative genetic test result does not mean that somebody does not have additional cancer risk. And family history becomes our kind of guiding star for understanding if there is still a need to change the cancer screening and prevention management for that individual and their family members. Brittany Harvey: Absolutely. Those are key points to understanding the important role of family history for each individual patient. So then moving to the next clinical question, Dr. Tung, what does the panel recommend regarding when and how multigene panel germline testing should be used, when germline genetic testing is indicated? Dr. Nadine Tung: Well, anytime multiple genes need to be tested, as Ms. Ricker said, because of the patient's own personal cancer history, or their family history of cancer and close relatives, it's appropriate to consider a multi-gene panel. And in truth, we rarely ever just order one gene these days. Perhaps we do if there's a known gene like a BRCA gene in the family, and a relative just wants to know if they have that. But it's not all that common. And to be clear, as Ms. Ricker is going to cover a bit later, we are recommending that the appropriate minimal panel at least include the genes relevant to the patient's own cancer and the cancers in their relatives. But it's worth thinking about what are some of the pros and cons of ordering genes beyond that, beyond the patient's own cancer or their relatives? Well, for pros, since a patient's awareness of their family history may be incomplete, testing for a larger number of cancer risk genes does ensure that significant pathogenic variants won't be overlooked. And sometimes, even if the family history is well known, pathogenic variants in important cancer risk genes can be found even when the family history would not have prompted testing for them. But it is important for clinicians to appreciate that bigger isn't necessarily better. Some larger panels may include genes for which management of pathogenic variants is not entirely clear and that can create anxiety or unnecessary screening. And if the clinician receiving the information is not well informed about the significance of the finding, that can lead to unnecessary treatment and sometimes even unnecessary surgeries. And I'd add one final point that clinicians must have a system for communicating reclassification of these variants, the ones with uncertain significance that we call VUS. Because as the number of genes tested increases, so does the likelihood of encountering these VUS. So I would say those are some of the main points about when to use the panel and when to think about larger or smaller panels. Brittany Harvey: Yes, I appreciate you reviewing both the pros and cons of expanding the genes included in multi-gene panel testing and the importance of variants of uncertain significance. So then Dr. Tung just touched on this, but speaking of minimal panels and which genes should be included, Ms. Ricker, what are the recommendations on which genes are generally recommended for germline genetic testing? Ms. Charité Ricker: I think this is one of the harder questions that our group took on as we were working on this guideline. I don't think there is a one size fits all and one easy answer to this question. However, we chose to approach it by selecting the more common solid tumors that oncologists see in their clinics and the ones where the role of genetic testing is most well defined, as well as some very rare tumors where they're kind of easy. So we know that all individuals with certain types of cancers, even though they are rare, should merit genetic testing regardless of age of diagnosis, family history. And so as we approached it, and I really appreciate ASCO's support in helping us develop some tools and tables that hopefully will be important aids for clinicians who are trying to make these decisions, we took the approach of, as Dr. Tung mentioned, selecting kind of a minimal set of recommended genes where most individuals who are informed in this area would agree that if nothing else was done, these genes should be done, but then also acknowledged that there is an expanding understanding about the impact of certain genes on cancer risk, and so then also provided a kind of a next level if somebody wanted to be more expansive, what we would recommend less strongly, but would be reasonable to consider. Then I think the other last piece that the committee felt was important to acknowledge is that given how common, in comparison to some of these genetic conditions that we work with, pathogenic variants in BRCA1 and BRCA2 can be, and also the important clinical impact of those genes along with the genes associated with Lynch syndrome, we felt that those were important to think about in the setting of all cancer patients. So if you're approaching a panel and thinking about what genes to include, looking at that kind of minimally recommended based on the patient's personal and family history, maybe the next level, which might include some additional genes that we have included in kind of the less strongly recommended category for those tumor types. And then consideration of the BRCA1 and 2 genes and genes associated with lynch syndrome, if they weren't already encapsulated by your other personal and family history considerations. Brittany Harvey: Definitely. This was a big lift for the panel to tackle, and the tools and tables that you mentioned are all available online with the publication in the Journal of Clinical Oncology. So listeners who are looking for more specifics on that can definitely refer to those tools and tables there. Dr. Tung, the last clinical question: which patient should be offered germline genetic testing, who will have or who have previously had somatic genetic testing? Dr. Nadine Tung: Identifying which genes identified through the tumor testing should trigger germline testing is really important for assessing our patients' future risk of cancer and their relatives. So during the development of our guidelines, the ASCO expert panel became aware that the ESMO Precision Medicine Working group had updated their recommendations for this topic, namely germline testing in response to tumor test findings. And these recommendations were based on the Memorial Sloan Kettering IMPACT registry, which consists of nearly 50,000 tumors and paired germline testing. Given the sheer volume of that data and the methods that ESMO used, our group decided to use that as a framework to develop our recommendations. The ASCO guideline provides a list of genes that, if found in the tumor, a pathogenic variant in those genes may prompt germline testing. And we offered or proposed two different approaches. The first approach, which is broad and perhaps simplest, involves doing germline testing if a pathogenic variant is found in any of the genes listed. But then we offer a conservative approach to test the germline for all highly actionable genes, like BRCA1 and 2, or lynch genes that are found in a tumor, but for less actionable genes, testing the germline only if the pathogenic variant is found in a tumor relevant to that gene. So, for example, ATM, if found in breast cancer or pancreatic cancer, would trigger germline testing with this approach, but not if found in lung cancer, whereas with the permissive first approach, you would simply test the germline if any pathogenic variant is found in any of the genes on the list. This latter, more conservative approach, while less sensitive for identifying every germline pathogenic variant, increases the likelihood that a pathogenic variant found in the tumor will actually be germline. That approach considers the limited resources available, such as genetic counselors, and respects trying not to overwhelm a system already stressed. Brittany Harvey: Thank you for reviewing both of those approaches and to you both for discussing all of the recommendations included in this guideline. Finally, to wrap us up, in your view, Ms. Ricker, what is the importance of this guideline and how will it impact both clinicians and patients with cancer? Ms. Charité Ricker: I hope that this guideline can open the door for more expansive and appropriate utilization of germline genetic testing. For me, I think about, from both the clinical and patient side, for example, all ovarian cancer patients have had a recommendation for germline genetic testing for many years. Nonetheless, data from multiple research studies has shown us that ovarian cancer patients still are not being tested universally, and this has important implications for their treatment plans and for their family members. And so even in the setting where genetic testing, if I can use the phrase, has been simple in that it didn't require family history, it didn't require even a specific age criteria, it was just broad, testing is not utilized as much as it should be, and then you step into the world of more complex decision making around genetic testing for other tumor types. And so we hope that this provides a framework to simplify that decision making process for providers to increase appropriate utilization. And then from the patient perspective, I also think about the lack of access of genetic testing in underrepresented communities and minoritized patient populations where there's many barriers that patients face in accessing genetic services. And so if we can help reduce the barriers for this piece of the genetic testing process, my hope is that that opens up better avenues for access to testing, not just for patients with certain tumor types, but for all patients from all communities and backgrounds. Brittany Harvey: Yes, those are key points. We hope that this guideline helps all patients access the appropriate testing to better inform their cancer prevention and treatment. So I want to thank you both so much for your work on this comprehensive guideline on germline genetic testing and all of the work that you put into it. And thank you for your time today. Ms. Ricker and Dr. Tung, Dr. Nadine Tung: Thank you. Ms. Charité Ricker: It was a pleasure to be here. Thank you. Brittany Harvey: And thank you to all of our listeners for tuning in to the ASCO Guidelines Podcast. To read the full guideline, go to www.asco.org/molecular-testing-and-biomarkers-guidelines. You can also find many of our guidelines and interactive resources in the free ASCO Guidelines app, available in the Apple App Store or the Google Play Store. If you have enjoyed what you've heard today, please rate and review the podcast and be sure to subscribe so you never miss an episode. The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.
durée : 01:18:28 - Les Nuits de France Culture - par : Antoine Dhulster - En 1994, pour "Les Nuits magnétiques", Simon Guibert demandait à des Européens ce que l'Europe représentait pour eux. - réalisation : Virginie Mourthé
durée : 01:18:30 - Les Nuits de France Culture - par : Philippe Garbit - En 1994, pour "Les Nuits magnétiques", Simon Guibert demandait à des Européens ce que l'Europe représentait pour eux.
durée : 00:02:22 - Français du monde - par : Emmanuel LANGLOIS - À deux mois, jour pour jour, de la cérémonie d'ouverture des JO de Paris 2024, en Suisse aussi on suivra de près les épreuves. Sur les rives du lac Léman, Lausanne accueille en effet le seul musée olympique au monde, comme l'explique ce Français, chargé de la communication du musée.
Sur la Une du Point, la photo montre un homme que le monde entier connaît, visage patibulaire, regard presque menaçant : le président russe. Avec ce titre : « Si Poutine gagne. » À l'approche du deuxième anniversaire de l'invasion russe en Ukraine, le 24 février, le Point échafaude des scénarios. Vus d'un pays où l'on redoute plus que toute l'hégémonie russe : la Lituanie, qui partage l'une de ses frontières avec la Biélorussie, alliée de Vladimir Poutine. « Un document du ministère allemand de la Défense a fuité il y a quelques semaines, raconte le Point. Il détaille le déroulé d'une offensive terrestre russe dans le sud de la Lituanie et l'extrême nord est de la Pologne, appelé corridor de Suwalki. Des territoires particulièrement vulnérables, car pris en étau entre la Biélorussie et l'enclave russe de Kaliningrad, où sont massées troupes, missiles hypersoniques et têtes nucléaires. »Ce n'est bien sûr qu'un scénario, mais il amène le Point à poser cette question : « L'alliance Atlantique se porterait-elle au secours des pays Baltes en cas d'invasion russe ? » L'hebdomadaire a interrogé Zygimantas Pavilionis, ancien ambassadeur lituanien aux États-Unis, qui se montre modérément optimiste. « Il redoute par-dessus tout de voir Donald Trump revenir à la Maison Blanche. Même en cas de réélection de Biden, il estime que l'Europe aurait tort d'y voir une assurance-vie. » Et il précise : « Le président américain pense que pour dissuader nos adversaires, il suffit de faire de beaux discours et de sourire comme Chamberlain. Le Premier ministre britannique qui, précise le Point, avait mis en place une politique d'apaisement avec Hitler. »Inquiétude pour le Sénégal« Quand le Sénégal, phare démocratique, vacille, titre l'Express. Le report de l'élection présidentielle, initialement prévue ce 25 février, plonge le pays dans l'inconnu. C'est la première fois, ajoute l'hebdomadaire, depuis l'instauration d'un régime présidentiel en 1963, qu'une élection est repoussée dans ce pays considéré comme un pôle de stabilité en Afrique de l'Ouest (...) Entre chaos et risque de dérive autoritaire dans un pays jusqu'ici épargné, l'avenir du Sénégal paraît soudain très sombre. »Plus pessimiste encore, l'Obs estime que « puisque Macky Sall a décidé de se maintenir au pouvoir au-delà de la fin de son mandat, le Sénégal pourrait connaître un scénario à la malienne où, après des élections contestées et des manifestations, l'armée a pris le pouvoir. Triste perspective pour la dernière démocratie d'Afrique de l'Ouest », ajoute l'Obs. Enfin, pour le Figaro Magazine, il ne s'agit pas « à proprement parler d'un coup d'État comme en ont connu ces dernières années le Niger, le Mali ou le Gabon, mais c'est en tout cas une grave dérive autoritaire, comme en République centrafricaine », estime l'hebdomadaire qui ose la comparaison avec ce pays en proie à la plus grande insécurité.Guerre de positionsM, le supplément du Monde, titre sur « la guerre de positions dans les familles juives. En France, le conflit entre Israël et le Hamas s'est invité jusqu'au sein des foyers juifs, révélant des points de vue antagonistes sur l'État hébreu et des manières différentes de vivre sa judéité. Exemple avec Elie, un ingénieur de 26 ans, qui, ne se sent pas "émotionnellement impliqué" par ces évènements qui se déroulent à 5 000 kilomètres de Paris, au Proche-Orient. Il se désole de la mort de 1 200 victimes innocentes, bien sûr, mais ni plus ni moins que si l'attentat s'était produit dans une autre contrée éloignée. "Ma mère était outrée, scandalisée", se souvient-il. Même chose face à la "riposte" de l'État hébreu, qu'il considère comme une réponse disproportionnée, alors que sa famille soutient le droit de l'État hébreu à se défendre ». Finalement, Elie n'aborde plus la question en famille. Même chose pour Ava, 34 ans, qui « dès le soir du 7 octobre, apprend que de proches amis de la famille, en Israël, des réservistes, ont quitté leur foyer pour rejoindre l'armée. "Il y a une vraie bascule à cette date", dit-elle. "J'ai arrêté d'essayer de leur expliquer ma manière de voir. J'ai compris que le discours de la paix n'était tout simplement plus entendable" ».À la Une de la Tribune Dimanche, Édouard Philippe, avec cette déclaration : « La compétition ne me fait pas peur. » L'ancien Premier ministre, nous dit la Tribune Dimanche, est « bien décidé à être candidat en 2027 ». Le Journal du Dimanche de son côté, fait sa Une sur Mayotte, et parle de « submersion migratoire », à l'occasion de la visite sur place du ministre de l'Intérieur Gérald Darmanin. Enfin, le Parisien Dimanche donne la parole à Gabriel Attal, le nouveau Premier ministre, selon lequel « il n'y aura "aucun temps mort" » dans sa gestion des affaires.
La journée mondiale de l'intelligence animale est célébrée chaque année, le 4 février. BSG rediffuse à cette occasion les 12 épisodes de la série "La bête en nous" avec Jessica Serra.Pourquoi les seins des femmes sont proéminents en permanence ? Chez les animaux, les mamelles des femelles se "dégonflent" lorsqu'elles ne sont plus en lactation. Pourquoi les seins persistent-ils chez les femmes ? Cette caractéristique a des coûts pour l'organisme; une biomasse importante est dédiée et la mobilité est impactée. Vus ces coûts, les principes d'évolution/d'adaptation suggèrent qu'il doit y avoir eu un certain avantage. Lequel ? Après les seins, le maquillage: serait-ce enfin une caractéristique unique des êtres humians ? Et bien non!! Le gypaète barbu (un gros vautour casseur d'os des Alpes) se maquille intentionnellement. Il prend des bains de boue ferrugineuse qui colore son plumage en jaune orangé. Cette coloration (régulièrement entretenue) exprime le caractère dominant et territorial de l'oiseau. Cette couleur s'adresse aux congénères erratiques, et les inciteraient à dégager. Reste le coup de foudre... Qu'en pense Jessica, notre invitée ?_______
ICD-11 = LD90.Y #LD90Y https://x.com/cureSYNGAP1/status/1730629792137883800 Adult paper and study https://x.com/AledoNeuro/status/1726206128390848604 AES - Lots of SYNGAP1 incl paper with ciitizen data https://x.com/JillianLMcKee/status/1731420167672942878 RT23 - Science: Repurposing, VUS, Genetic Tx & Biomarkers - Chow https://x.com/CNSdrughunter/status/1730233903602872424 - VUS https://x.com/CNSdrughunter/status/1730268276989571512 - Genetic Therapies https://x.com/dretico/status/1730298959824875741 FD23 - 60 Families from 16 Countries. Awesome leadership. Sign up for Adult Study led by Dr. Andrade, if you loved one is 17 or over please email Ilakkiah.Chandran@uhn.ca Sign up for NET Study, email KHuba@jcu.edu check out #S10e122 and the #SRFFrazier Release if you are not up to date. (14 so far, ½ returning) https://www.eurekalert.org/news-releases/1006753 Give all three of our podcasts 5 stars everywhere. https://podcasts.apple.com/us/channel/syngap1-podcasts-by-srf/id6464522917 This is a podcast subscribe! https://podcasts.apple.com/us/podcast/syngap10-weekly-10-minute-updates-on-syngap1/id1560389818 Episode 125 of #Syngap10 - December 6, 2023 #epilepsy #autism #intellectualdisability #id #anxiety #raredisease #epilepsyawareness #autismawareness #rarediseaseresearch #SynGAPResearchFund #CareAboutRare #PatientAdvocacy #GCchat #Neurology #GeneChat
Vus de notre époque, les dinosaures ressemblent tous à des créatures qui ont été contemporaines entre elles. Pourtant, il y a bien une frise temporelle à prendre en compte. Certains dinosaures sont même plus proches de nous dans le temps... que de leurs propres congénères ! Learn more about your ad choices. Visit megaphone.fm/adchoices
Click to listen to episode (4:53).Sections below are the following:Transcript of AudioAudio Notes and AcknowledgmentsImagesSourcesRelated Water Radio EpisodesFor Virginia Teachers (Relevant SOLs, etc.)Unless otherwise noted, all Web addresses mentioned were functional as of 11-6-23. TRANSCRIPT OF AUDIO From the Cumberland Gap to the Atlantic Ocean, this is Virginia Water Radio for the weeks of November 13 and November 20, 2023. MUSIC – ~28 sec – Lyrics: “What you gonna do when the river runs dry, when there's no more water in your well? You won't know when to give it that one last try, you won't be warned before the final bell.” That's part of “River Runs Dry,” by Blacksburg, Va., musician Kat Mills. The song, in which water sources are metaphors for the songwriter's inspiration, opens a Thanksgiving-season episode featuring expressions of gratitude for literal water sources not running dry. Here are three such expressions, by people from North America, Vietnam, and Kenya. 1. The Haudenosaunee people, an alliance of six Native American tribes that was formerly known as the Iroquois Confederacy, has a traditional “Thanksgiving Address of Greetings to the Natural World.” The address includes greetings to 17 aspects of the world, such as people, plants and animals, the moon and stars, winds and thunder, and the creator. Here's the greeting to The Waters: “We give thanks to all the waters of the world for quenching our thirst and providing us with strength. Water is life. We know its power in many forms- waterfalls and rain, mists and streams, rivers and oceans. With one mind, we send greetings and thanks to the spirit of Water. Now our minds are one.” 2. Vietnamese spritutal leader Thich Nhat Hanh has written many “gathas,” that is, short reflections or meditations, on daily activities. Here is his gatha for “Turning on the Water.” “Water comes from high mountain sources. Water runs deep in the Earth. Miraculously, water comes to us and sustains all life. My gratitude is filled to the brim.” And 3. About 10 years ago, a group of Kenyan schoolgirls wrote a poem in gratitude for a newly drilled well in their community. Here's that poem. Dear water, It was hard to get to you. Waking up at dawn Buckets on our heads Donkeys loaded with jerrycans. Miles we walked In the scorching heat To look for you. Dear water, At last you came. Sweet water Our backs are rested The miles are no more Diseases are gone. For you are closer to us. Dear water, You are such a blessing. One can find countless other expressions of awareness of and gratitude for water's many vital purposes in writings by poets, politicians, professors, prophets, pundits, and plenty of others. For one last, short reading, we return to one of the water metaphors in our opening music, and quote a Benjamin Franklin comment that applies not only to water but also to anything one has and can lose: “When the well's dry, we know the worth of water.” Thanks to people everywhere who know and speak about the worth of water. Thanks also to Kat Mills for permission to use this episode's music, and—with hope that this won't be the case for you or anyone—we close with about 30 more seconds of “River Runs Dry.” Happy Thanksgiving!MUSIC - ~30 sec – Lyrics: “What you gonna do when the river runs dry? Guess I'll have to pack up and leave my home.” SHIP'S BELL Virginia Water Radio is produced by the Virginia Water Resources Research Center, part of Virginia Tech's College of Natural Resources and Environment. For more Virginia water sounds, music, or information, visit us online at virginiawaterradio.org, or call the Water Center at (540) 231-5624. Thanks to Stewart Scales for his banjo version of “Cripple Creek” to open and close this episode. In Blacksburg, I'm Alan Raflo, thanking you for listening, and wishing you health, wisdom, and good water. AUDIO NOTES AND ACKNOWLEDGEMENTS “River Runs Dry,” by Kat Mills, is on the 2003 album “Long Time,” from Sweetcut Music; used with permission. More information about Kat Mills is available online at https://katmills.com/home. This music was used previously by Virginia Water Radio most recently in Episode 557, 12-28-20. Click here if you'd like to hear the full version (1 min./11 sec.) of the “Cripple Creek” arrangement/performance by Stewart Scales that opens and closes this episode. More information about Mr. Scales and the group New Standard, with which Mr. Scales plays, is available online at http://newstandardbluegrass.com. IMAGES Following are images of some Virginia water bodies for which the Commonwealth's citizens can be thankful. Photographs by Virginia Water Radio. Lake Drummond in Dismal Swamp, April 30 2005.Catoctin Creek at Featherbed Lane in Loudoun County, June 25, 2010.Jeremy's Run near Rileyville in Page County, July 22, 2012.Craig Creek in Montgomery County, April 26, 2015. SOURCES USED FOR AUDIO AND OFFERING MORE INFORMATION AZ Quotes, “Benjamin Franklin Quotes About Water,” online at https://www.azquotes.com/author/5123-Benjamin_Franklin/tag/water. This is the source of the Franklin quote used in the audio. Be Here Now Network, “44 Mindful Moves in Daily Life—Thich Nhat Hanh's Gathas,” online at https://beherenownetwork.com/thich-nhat-hanhs-gathas/. This is the source of the Thich Nhat Hahn quote used in the audio. Borgen Project, “Kenyan Schoolgirls Dedicate a Poem to Water,” by Sarah Sheppard, September 7, 2015, online at https://borgenproject.org/kenyan-schoolgirls-poem/. Columban Interreligious Dialogue, “Being Grateful for the Gift of Water, Cagayan de Oro, Philippines,” online at https://columbanird.org/being-grateful-for-the-precious-gift-of-water/. Abu Amina Elias, “Hadith on Water: Best charity is giving water to thirsty people,” posted by Daily Hadith Online, July, 23, 2017, online at https://www.abuaminaelias.com/dailyhadithonline/2017/07/23/best-sadaqah-water-thirsty/. GoodReads, “Benjamin Franklin/Quotes/Quotable Quote,” online at https://www.goodreads.com/quotes/53013-when-the-well-is-dry-we-know-the-worth-of. Zachiah Murray, “How to Do Gatha Practice,” posted by Lion's Roar, July 25, 2022, online at https://www.lionsroar.com/how-to-practice-gathas/. Smithsonian Institution's National Museum of the American Indian, “Haudenosaunee Guide for Educators,” 2009, online (as a PDF) at https://americanindian.si.edu/sites/1/files/pdf/education/HaudenosauneeGuide.pdf. Thai Plum Village, “Thich Nhat Hanh,” online at https://www.thaiplumvillage.org/thichnhathanh. Thich Nhat Hanh Foundation, online at https://thichnhathanhfoundation.org/thich-nhat-hanh. Saffet Catovioc, “Islamic Texts Related to Water,” posted by Green Faith Water Shield, undated, online (as a PDF) at https://www.faithinwater.org/uploads/4/4/3/0/44307383/islamic_sacred_texts-water-greenfaith.pdf. World Vision, “Video: Schoolgirls share their poem ‘Dear Water,'” May 6, 2019, online at https://www.worldvision.org/clean-water-news-stories/video-schoolgirls-share-poem-dear-water. RELATED VIRGINIA WATER RADIO EPISODES All Water Radio episodes are listed by category at the Index link above (http://www.virginiawaterradio.org/p/index.html). See particularly the “Overall Importance of Water” subject category. Following are links to other episodes for Thanksgiving. Episode 291, 11-23-15 – Thanks for Musical Measures of Water.Episode 343, 11-21-16 – Wild Turkey and Water.Episode 395, 11-20-17 – Thanks for the Water – 2017 edition.Episode 500, 11-25-19 – The Variety of Virginia's Water Story – for 500th episode.Episode 642, 11-21-22 – Thanks for the Water – 2022 Edition. FOR VIRGINIA TEACHERS – RELATED STANDARDS OF LEARNING (SOLs) AND OTHER INFORMATION Following are some Virginia Standards of Learning (SOLs) that may be supported by this episode's audio/transcript, sources, or other information included in this post. 2020 Music SOLs SOLs at various grade levels that call for “examining the relationship of music to the other fine arts and other fields of knowledge.” 2017 English SOLs 5.4, 6.5, 7.4, 8.4, 8.5, 9.3, 9.4, 10.3, 10.4, 11.4 – Symbols, imagery, figurative language, and other literary devices. 2018 Science SOLs Grades K-4: Living Systems and Processes1.5 – Animals, including humans, have basic life needs that allow them to survive. Grades K-5: Earth and Space Systems3.7 – There is a water cycle and water is important to life on Earth. Grades K-5: Earth ResourcesK.11 – Humans use resources.3.8 – Natural events and humans influence ecosystems.4.8 – Virginia has important natural resources. Grade 66.6 – Water has unique physical properties and has a role in the natural and human-made environment.6.9 – Humans impact the environment and individuals can influence public policy decisions related to energy and the environment. Life ScienceLS.9 – Relationships exist between ecosystem dynamics and human activity. Earth ScienceES.6 – Resource use is complex.ES.8 – Freshwater resources influence and are influenced by geologic processes and human activity. 2023 History and Social Science SOLs Grade One: Commonwealth of Virginia1.2 – The student will apply history and social science skills to explain how communities honor local and national traditions and recognize designated Virginia holidays. Grade Two: United States of America2.3 – The student will apply history and social science skills to explain how communities honor local and national traditions and recognize designated Virginia holidays.2.5 – The student will use history and social science skills to identify the geographic location, use of resources, and identify the contributions of Indigenous peoples past and present. Grade 5: United States History to 1865USI.2 – The student will apply history and social science skills to describe how early cultures developed throughout North America. Grade 8: World GeographyWG.2 – The student will apply social science skills to evaluate the significance of natural, human, and capital resources.WG.3 – The student will analyze the characteristics of the United States and Canadian regions by (among other things) analyzing cultural influences and landscapes.WG.7 – The student will analyze the characteristics of the Sub-Saharan African region by (among other things) analyzing cultural influences and landscapes.WG.9 – The student will analyze the characteristics of the South Asian and Southeast Asian regions by (among other things) analyzing cultural influences and landscapes.WG.14 – The student will apply history and social science skills to determine cultural patterns and interactions across time and place. Grade 11: Virginia and United States HistoryVUS.1 – The student will apply history and social science skills to describe the early North America by distinguishing how different Indigenous People of North America used available resources to develop their culture, language, skills and perspectives.Vi
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Click to listen to episode (5:03).Sections below are the following:Transcript of AudioAudio Notes and AcknowledgmentsImagesExtra InformationSourcesRelated Water Radio EpisodesFor Virginia Teachers (Relevant SOLs, etc.)Unless otherwise noted, all Web addresses mentioned were functional as of 9-1-23. TRANSCRIPT OF AUDIO From the Cumberland Gap to the Atlantic Ocean, this is Virginia Water Radio for the weeks of September 4 and September 11, 2023. MUSIC – ~22 sec – Lyrics: “Wake up in the morning and get to work; wake up in the morning and get to work. Got a lot of work to do, gonna go do it, gotta get to it.” That's part of “Get to Work,” by the Harrisionburg- and Rockingham County, Va.-based band, The Steel Wheels, from their 2019 album, “Over the Trees.” It sets the stage for a water-and-work quiz game, honoring Labor Day by exploring some water-related jobs. In this game, I'll read 10 short samples of people describing their work connected to water; you'll have a couple of seconds of river sounds to guess the job, then I'll tell you the answer. Let's get to it! No. 1. I manage places where marine or freshwater creatures are grown for food, restoration, or other purposes. [RIVER SOUNDS - ~2 SEC] That's an aquaculturist. No. 2. I ply big rivers on large, flat vessels full of coal, grains, and other goods. [RIVER SOUNDS - ~2 SEC] That's a crew member on a river barge. No. 3. I'm a scientist who studies fish. [RIVER SOUNDS - ~2 SEC] That's an ichthyologist. No. 4. I'm a scientist who studies inland waters, both fresh and salty. [RIVER SOUNDS - ~2 SEC] That's a limnologist. No. 5. I respond to often dangerous emergencies with the aid of trucks, hoses, pumps, and other equipment. [RIVER SOUNDS - ~2 SEC] That's a firefighter. No. 6. I use filters, chemicals, and tests to treat water going from sources to customers. [RIVER SOUNDS - ~2 SEC] That a water-supply plant worker. No. 7. I use filters, chemicals, and tests to treat used water and send it back to water sources. [RIVER SOUNDS - ~2 SEC] That's a wastewater-treatment plant worker. No. 8. I board huge ships in open waters, then guide the ships safely into port. [RIVER SOUNDS - ~2 SEC] That's a harbor pilot. No. 9. I work to ensure safe, accessible, and effective use of a water-recreation facility. [RIVER SOUNDS - ~2 SEC] That's a swimming pool manager, lifeguard, or water exercise instructor. And No. 10. I use powerful drills to provide access to groundwater. [RIVER SOUNDS - ~2 SEC] That's a water-well contractor. Other water-related jobs include boat building, farming, public health, managing lakes and dams, managing watersheds, identifying wetlands, and lots more. As Labor Day comes and goes, here's a big thank you to people who work to provide, manage, navigate, protect, and teach and learn about our common wealth of water. Thanks also to The Steel Wheels for permission to use part of “Get to Work.” We close with some more music, this time by renowned musician and former Charlottesville, Virginia, resident John McCutcheon. From his 1998 album “Four Seasons: Autumnsongs,” here's about 35 seconds of “Labor Day.” MUSIC – ~36 sec – Lyrics: “Labor Day, Labor Day, September or the first of May. To all who work this world we say, ‘Happy Labor Day.'” SHIP'S BELL Virginia Water Radio is produced by the Virginia Water Resources Research Center, part of Virginia Tech's College of Natural Resources and Environment. For more Virginia water sounds, music, or information, visit us online at virginiawaterradio.org, or call the Water Center at (540) 231-5624. Thanks to Ben Cosgrove for his version of “Shenandoah” to open and close this episode. In Blacksburg, I'm Alan Raflo, thanking you for listening, and wishing you health, wisdom, and good water. AUDIO NOTES AND ACKNOWLEDGEMENTS The river sounds heard in this episode were recorded by Virginia Water Radio beside the New River at Radford, Va., on October 6, 2013. “Get to Work,” from the 2019 album, “Over the Trees,” is copyright by The Steel Wheels, used with permission. More information about The Steel Wheels is available online at http://www.thesteelwheels.com/. This music was used previously by Virginia Water Radio in Episode 558, 1-4-21. “Labor Day,” from the 1998 album “Four Seasons: Autumnsongs,” on Rounder Records, is copyright by John McCutcheon/Appalsongs and Si Kahn/Joe Hill Music, used with permission of John McCutcheon. More information about John McCutcheon is available online at http://www.folkmusic.com/. Thanks to John Plunkett of Appalseed Productions for his help in acquiring permission to use this music. More information about Appalseed Productions is available online at https://appalseed-productions-2.square.site/. Click here if you'd like to hear the full version (2 min./22 sec.) of the “Shenandoah” arrangement/performance by Ben Cosgrove that opens and closes this episode. More information about Mr. Cosgrove is available online at http://www.bencosgrove.com. IMAGES (Except as otherwise noted, photographs are by Virginia Water Radio.) A Virginia Tech worker testing fire-hyrdrant pressure on the university campus in Blacksburg, March 10, 2017.A well-drilling rig at a Montgomery County, Virginia, residential project, June 20, 2014.A barge transporting stone on the Ohio River at Huntington, West Virginia, November 6, 2011.A commercial ship on the Chesapeake Bay as viewed from Kent Island, Maryland, September 22, 2010.EXTRA INFORMATION ABOUT LABOR DAY The following information is from U.S. Department of Labor, “History of Labor Day,” online at https://www.dol.gov/general/laborday/history. “Before it was a federal holiday, Labor Day was recognized by labor activists and individual states. After municipal ordinances were passed in 1885 and 1886, a movement developed to secure state legislation. New York was the first state to introduce a bill, but Oregon was the first to pass a law recognizing Labor Day, on February 21, 1887. During 1887, four more states – Colorado, Massachusetts, New Jersey and New York – passed laws creating a Labor Day holiday. By the end of the decade Connecticut, Nebraska and Pennsylvania had followed suit. By 1894, 23 more states had adopted the holiday, and on June 28, 1894, Congress passed an act making the first Monday in September of each year a legal holiday.” SOURCES USED FOR AUDIO AND OFFERING MORE INFORMATION American Society of Limnology and Oceanography, “What is Limnology?” Online at https://www.aslo.org/what-is-aquatic-science/what-is-limnology/. Encyclopedia Britannica, “May Day,” by Meg Matthais, online at https://www.britannica.com/topic/May-Day-international-observance. Fire Safety USA, “All [Product] Categories,” online at https://firesafetyusa.com/collections/all-products. National Oceanic and Atmospheric Administration/National Ocean Service, “What is aquaculture?” Online at this link. NPR, “Harbor Pilots Reap High Rewards for Dangerous Job,” by Gloria Hillard, March 21, 2012. NPR, “What is May Day?” For the most part, the opposite of capitalism,” by Emma Bowman, May 1, 2023. Tennessee Valley Authority, “Commodities Shipped on the River,” online at https://www.tva.com/environment/managing-the-river/commodities-shipped-on-the-river. University of New Mexico, “Position Classification Description: Aquatics Manager,” online at https://jobdescriptions.unm.edu/detail.php?v&id=I6001. U.S. Department of Labor, “History of Labor Day,” online at https://www.dol.gov/general/laborday/history. U.S. Environmental Protection Agency, “Learn About Private Water Wells,” online at https://www.epa.gov/privatewells/learn-about-private-water-wells. Virginia Cooperative Extension/Virginia Household Water Quality Program, “Wellcheck Contractor List,” online at https://www.wellwater.bse.vt.edu/wellcheck-contractor-list.php. Karen Zraik, “What is Labor Day? A History of the Workers' Holiday,” New York Times, September 4, 2023 (first published in 2018).RELATED VIRGINIA WATER RADIO EPISODES All Water Radio episodes are listed by category at the Index link above (http://www.virginiawaterradio.org/p/index.html). See particularly the “Overall Importance of Water” subject category. Following are links to some other episodes on Labor Day or water-related labor.Episode 279, 8-24-15 – Oysters, Nitrogen, and the Chesapeake Bay. Episode 378, 7-24-17 – The Complicated Challenge of Cleaner Water. Episode 436, 9-3-18 – Labor Day, “Sandy Boys,” and the Big Sandy River. Episode 578, 5-24-21 – Water Well Construction is an Ancient and Modern Human Practice. Episode 635, 8-29-22 – A Fishing Focus for Labor Day, Featuring the Northern Neck Chantey Singers FOR VIRGINIA TEACHERS – RELATED STANDARDS OF LEARNING (SOLs) AND OTHER INFORMATION Following are some Virginia Standards of Learning (SOLs) that may be supported by this episode's audio/transcript, sources, or other information included in this post. 2020 Music SOLs SOLs at various grade levels that call for “examining the relationship of music to the other fine arts and other fields of knowledge.” 2018 Science SOLs Grades K-5: Earth and Space Systems3.7 – There is a water cycle and water is important to life on Earth. Grades K-5: Earth Resources3.8 – Natural events and humans influence ecosystems.4.8 – Virginia has important natural resources. Grade 66.6 – Water has unique physical properties and has a role in the natural and human-made environment.6.8 – Land and water have roles in watershed systems.6.9 – Humans impact the environment and individuals can influence public policy decisions related to energy and the environment. Earth ScienceES.6 – Resource use is complex.ES.8 – Freshwater resources influence and are influenced by geologic processes and human activity.ES.10 – Oceans are complex, dynamic systems subject to long- and short-term variations.
In the finale of our series "Conversations about Hypertrophic Cardiomyopathy", Dr Ankur Kalra welcomes, Dr Anjali Tiku Owens, for a dynamic and practical discussion. Dr Owens is Medical Director of the Center for Inherited Cardiac Disease and Associate Professor of Medicine at the Hospital of the University of Pennsylvania. This series is supported by an unrestricted educational grant from Bristol Myers Squibb. Please see www.camzyosrems.com for important safety information. In this week's episode, Dr Kalra and Dr Owens take us on a journey through the complexities of hypertrophic cardiomyopathy (HCM), with focus on the diagnostic challenges and breakthroughs in this field. Emphasising with the critical importance of making accurate diagnoses, Dr Owens shares her insights into identifying the common mimickers of HCM through a structured approach starting with taking the patients history. As the conversation delves deeper, Dr Owens discusses the various diagnostic tools and tests used to rule out other conditions and uncover the underlying aetiology. She navigates us through the algorithm for interpreting genetic test results, differentiating pathogenic variants, benign variants and variants of uncertain significance (VUS). Dr Owens talks about the wider implications for family members and the cases in which she recommends screening. Dr Kalra asks Dr Owens about her approach to exercise in HCM patients. Additionally, they cover the debated topic of defibrillator therapy and the use of HCM Risk-SCD risk calculator. Dr Owens provides an overview of the treatment paradigms for HCM, touching on haemodynamic classifications, symptomatology and the evaluation of sudden death risk. What are the most common mimickers of HCM? What is Dr Owens and her heart team approach to decision making? What is the role of genetic testing in patients with HCM? This content is intended for US-based physicians.
durée : 02:14:59 - Les Nuits de France Culture - par : Albane Penaranda - Par Claude Roland-Manuel - Réalisation Marie-France Thivot
CLICK HERE to listen to episode audio (5:35).Sections below are the following: Transcript of Audio Audio Notes and Acknowledgments ImagesExtra InformationSources Related Water Radio Episodes For Virginia Teachers (Relevant SOLs, etc.). Unless otherwise noted, all Web addresses mentioned were functional as of 5-29-23. TRANSCRIPT OF AUDIO From the Cumberland Gap to the Atlantic Ocean, this is Virginia Water Radio for the weeks of June 26 and July 3, 2023. MUSIC – ~8 sec –lyrics: “Ah reflections in the window pane, fallin' in love, in the drivin' rain.” That's part of “Driving Rain,” by the Charlottesville- and Nelson County, Va.-based band, Chamomile and Whiskey. The song's a love story, but its title and main phrase lead in to a legal water story—that is, how does rain, and any other water on the landscape, become water covered by the federal Clean Water Act, specifically by the Act's phrase, the “waters of the United States?” On May 25, 2023, the U.S. Supreme Court wrote a new chapter in this story. Passed in 1972, the Clean Water Act's main goal is “to restore and maintain the chemical, physical, and biological integrity of the Nation's waters.” The Act states that it applies to “navigable waters,” defined as “waters of the United States, including the territorial seas,” and amendments in 1977 added wetlands that are adjacent to other covered waters. All waters covered by the Act are known as “jurisdictional waters,” and any discharges into such waters require a federal permit. Defining what waters—particularly what wetlands and small tributaries—are jurisdictional has enormous impact on the Act's environmental and economic reach. Many questions and legal challenges have been raised over the meaning of “waters of the United States,” its relation to the term “navigable waters,” and the Act's implementation by the U.S. EPA and the Army Corps of Engineers. The Supreme Court has a long history of decisions on these questions. Here are short accounts of five important Court decisions, including the most recent one, affecting the Act's jurisdiction. 1. The 1870 Daniel Ball decision held that “navigable waters of the United States” are those that support commerce between states or with foreign countries. Later Supreme Court cases expanded that test to include waters that formerly supported, or could support, such commerce. 2. The 1985 Riverside Bayview decision affirmed that the Act covered wetlands adjacent to other “waters of the United States.” 3. The 2001 SWANCC decision held that the Act did not cover wetlands solely on the basis of their use by migratory birds. 4. In the complicated 2006 Rapanos decision, a plurality opinion by Justice Antonin Scalia held that the Act covers only relatively permanent water bodies that form recognizable geographical features, plus wetlands only if they have a “continuous surface connection” to other covered waters. Justice Anthony Kennedy's concurring opinion held that wetlands were covered if they have a quote, “significant nexus,” unquote, to conditions in other covered waters. And 5. The 2023 Sackett decision returned to the Scalia opinion of 2006, while dismissing Justice Kennedy's “significant nexus” test. So the Court now holds that the Act covers only, quote, “relatively permanent, standing or continuously flowing water bodies, forming geographical features…described in ordinary parlance as streams, oceans, rivers, and lakes,” unquote; plus wetlands with a “continuous surface connection” to such water bodies. This removes many previously regulated wetlands from the Act's jurisdiction. While the Sackett decision focused particularly on wetlands, the new test articulated in the decision may have impacts as well for small streams that do not flow year-round. Through amendments, executive orders, agency actions, and litigation, defining the reach of the Clean Water Act has been a long, meandering story. It's probably safe to say that more turns await. Thanks to Chamomile and Whiskey for permission to use “Driving Rain.” We close with some more music, this time from Wake Up Robin, with musicians from California, New York, North Carolina, New York, and Washington. The song's watery title recalls debates over what water bodies are, so to speak, enough like navigable waters to be covered by the Clean Water Act. Here's about 20 seconds of “Like a River.” MUSIC – ~19 sec – instrumental. SHIP'S BELL Virginia Water Radio is produced by the Virginia Water Resources Research Center, part of Virginia Tech's College of Natural Resources and Environment. For more Virginia water sounds, music, or information, visit us online at virginiawaterradio.org, or call the Water Center at (540) 231-5624. Thanks to Stewart Scales for his banjo version of “Cripple Creek” to open and close this episode. In Blacksburg, I'm Alan Raflo, thanking you for listening, and wishing you health, wisdom, and good water. AUDIO NOTES AND ACKNOWLEDGEMENTS “Driving Rain,” from the 2012 album “The Barn Sessions,” is copyright by Chamomile and Whiskey and by County Wide Records, used with permission. More information about Chamomile and Whiskey is available online at http://www.chamomileandwhiskey.com/. This music was used previously by Virginia Water Radio most recently in Episode 650, 3-6-23. “Like a River,” from the 2018 album “Wake Up Robin,” on Great Bear Records, by the group of the same name, is used with permission of Andrew VanNorstrand. More information about the album and band is available online at https://wakeuprobin.bandcamp.com, and at https://www.wakeuprobin.com/. Virginia Water Radio thanks Stephen Schoenholtz, Kevin McGuire, and Daniel McLaughlin, all of the Virginia Water Resources Research Center and the Virginia Tech Department of Forest Resources and Environmental Conservation, for their help with this episode. Click here if you'd like to hear the full version (1 min./11 sec.) of the “Cripple Creek” arrangement/performance by Stewart Scales that opens and closes this episode. More information about Mr. Scales and the group New Standard, with which Mr. Scales plays, is available online at http://newstandardbluegrass.com.IMAGES (Photographs are by Virginia Water Radio.) What does the definition of “waters of the United States” say about the following areas? Marsh at Eyre Hall near Cheriton, Virginia (Northampton County), October 6, 2007.Bog near the community of Interior in Giles County, Virginia, October 3, 2009.Wetland-lake complex in the Loup River watershed near Valentine, Nebraska, July 14, 2011.Upper photo: Dry (at the time) seasonal floodplain pond in Heritage Park in Blacksburg, Virginia (Montgomery County), May 27, 2023; lower photo: the same pond in wet conditions three days later, on May 30, 2023. EXTRA INFORMATION ABOUT THE U.S. SUPREME COURT CASE SACKETT v. EPA (2023) The following is quoted from the first page of the Supreme Court's syllabus of the Sackett v. EPA case, decided May 25, 2023; the information was accessed online (from a PDF) at https://www.supremecourt.gov/opinions/22pdf/21-454_4g15.pdf, May 29, 2023. SACKETT ET UX . v. ENVIRONMENTAL PROTECTION AGENCY ET AL . CERTIORARI TO THE UNITED STATES COURT OF APPEALS FOR THE NINTH CIRCUIT No. 21–454. Argued October 3, 2022—Decided May 25, 2023 Petitioners Michael and Chantell Sackett purchased property near Priest Lake, Idaho, and began backfilling the lot with dirt to prepare for building a home. The Environmental Protection Agency informed the Sacketts that their property contained wetlands and that their backfilling violated the Clean Water Act, which prohibits discharging pollutants into “the waters of the United States.” 33 U. S. C. §1362(7). The EPA ordered the Sacketts to restore the site, threatening penalties of over $40,000 per day. The EPA classified the wetlands on the Sacketts' lot as “waters of the United States” because they were near a ditch that fed into a creek, which fed into Priest Lake, a navigable, intrastate lake. The Sacketts sued, alleging that their property was not “waters of the United States.” The District Court entered summary judgment for the EPA. The Ninth Circuit affirmed, holding that the CWA covers wetlands with an ecologically significant nexus to traditional navigable waters and that the Sacketts' wetlands satisfy that standard. Held: The CWA's use of “waters” in §1362(7) refers only to “geographic[al] features that are described in ordinary parlance as ‘streams, oceans, rivers, and lakes' ” and to adjacent wetlands that are “indistinguishable” from those bodies of water due to a continuous surface connection. Rapanos v. United States, 547 U. S. 715, 755, 742, 739 (plurality opinion). To assert jurisdiction over an adjacent wetland under the CWA, a party must establish “first, that the adjacent [body of water constitutes] . . . ‘water[s] of the United States' (i.e., a relatively permanent body of water connected to traditional interstate navigable waters); and second, that the wetland has a continuous surface connection with that water, making it difficult to determine where the ‘water' ends and the ‘wetland' begins.” Ibid. Pp. 6–28. SOURCES USED FOR AUDIO AND OFFERING MORE INFORMATION Justia Company, “U.S. Supreme Court/The Daniel Ball, 77 U.S. 557 (1870), online at https://supreme.justia.com/cases/federal/us/77/557/. Justia Company, “U.S. Supreme Court/United States v. Riverside Bayview Homes, Inc., 474 U.S. 121 (1985), online at https://supreme.justia.com/cases/federal/us/474/121/.Justia Company, “U.S. Supreme Court/Solid Waste Agency of Northern Cook County v. U.S. Army Corps of Engineers, 531 U.S. 159 (2001),” online at https://supreme.justia.com/cases/federal/us/531/159/. Justia Company, “U.S. Supreme Court/Rapanos v. United States, 547 U.S. 715 (2006),” online at https://supreme.justia.com/cases/federal/us/547/715/. Justia Company, “U.S. Supreme Court/Sackett v. Environmental Protection Agency, 598 U.S. ___ (2023),” online at https://supreme.justia.com/cases/federal/us/598/21-454/. John Krunzel and Andrew Chung, “US Supreme Court rules against EPA in wetlands regulation challenge,” Reuters, May 25, 2023. Adam Liptak, “Supreme Court Limits E.P.A.'s Power to Address Water Pollution,” New York Times, May 25, 2023. John Lowenthal, “Summary on Sackett v. US EPA,” Society of Wetland Scientists [McLean, Va.], e-mail message sent May 26, 2023. Supreme Court of the United States, No. 21-454, Michael Sackett, et ux., Petitioners, v. Environmental Protection Agency, et al., May 25, 2023. Cited as 598 U.S.__(2023). The case was argued October 3, 2022. The opinions (majority plus two concurring) are available online (as a PDF) at https://www.supremecourt.gov/opinions/22pdf/21-454_4g15.pdf. Nina Totenberg, “The Supreme Court has narrowed the scope of the Clean Water Act.” NPR, May 25, 2023. U.S. Environmental Protection Agency (EPA):“EPA and Army Finalize Rule Establishing Definition of WOTUS and Restoring Fundamental Water Protections,” December 30, 2022, news release.“Revising the Definition of ‘Waters of the United States': Final Revised Definition of ‘Waters of the United States',” online at https://www.epa.gov/wotus/revising-def
CLICK HERE to listen to episode audio (5:32).Sections below are the following: Transcript of Audio Audio Notes and Acknowledgments ImageExtra InformationSources Related Water Radio Episodes For Virginia Teachers (Relevant SOLs, etc.). Unless otherwise noted, all Web addresses mentioned were functional as of 4-14-23. TRANSCRIPT OF AUDIO From the Cumberland Gap to the Atlantic Ocean, this is Virginia Water Radio for the weeks of April 17 and April 24, 2023. This episode, the sixth in a series on water in U.S. civil rights history, continues our exploration of water connections to the 14th Amendment of the U.S. Constitution. MUSIC – ~23 sec – instrumental. That's part of “Mississippi Farewell,” by Dieter van der Westen. It opens an episode on how Mississippi River water and public health were the context for the first U.S. Supreme Court ruling on the meaning and extent of the 14th Amendment. One of three constitutional amendments passed and ratified soon after the Civil War, the 14th Amendment aimed to guarantee citizenship rights and legal protections, especially for newly freed Black people. In 1873, the Supreme Court issued a ruling in three consolidated cases about wastes from livestock processing facilities in Louisiana; this ruling had decades-long implications for key parts of the 14th Amendment and for civil rights. Have a listen to the music for about 25 more seconds, and see if you know the name of these consolidated Supreme Court cases. MUSIC – ~27 sec – instrumental. If you guessed The Slaughterhouse Cases, you're right! As of the 1860s, some 300,000 livestock animals were slaughtered annually at facilities along the Mississippi River in and around New Orleans, upstream of water supply intakes, with much of the untreated waste from the process reaching the river. Concerns over the potential for diseases from this water contamination led the Louisiana legislature to pass the Slaughterhouse Act of 1869. This law authorized a single corporation to operate one slaughterhouse facility on the Mississippi downstream of New Orleans and required all butchers in the area to use that facility. Butchers' organizations filed suit, alleging that the law infringed on their work rights in violation of the 14th Amendment's clauses prohibiting states from abridging the privileges or immunities of citizens of the United States and from denying people equal protection of the laws. On April 14, 1873, the Supreme Court issued its ruling, with the majority opinion written by Justice Samuel Miller. Miller's opinion upheld the Louisiana law, finding that that the slaughterhouse monopoly granted by the state was within the police powers to provide for public health and sanitation. Justice Miller went further, however, in asserting that the 14th Amendment gave the federal government jurisdiction only over federal, or national, citizenship rights—that is, privileges and immunities—but not over rights historically considered to result from state citizenship. Miller also asserted that the amendment's equal protection clause applied only to the case of Black people emancipated from slavery. The Slaughterhouse Cases decision, along with other related Supreme Court decisions during the Reconstruction Era, created long-lasting legal barriers to federal government efforts against state-level violations of civil rights, such as racial and gender discrimination, voting restrictions, and failure to prevent or prosecute racially-motivated crimes of violence. Thanks to Dieter van der Westen and Free Music Archive for making this week's music available for public use, and we close with about 20 more seconds of “Mississippi Farewell.” MUSIC – ~22 sec – instrumental. SHIP'S BELL Virginia Water Radio is produced by the Virginia Water Resources Research Center, part of Virginia Tech's College of Natural Resources and Environment. For more Virginia water sounds, music, or information, visit us online at virginiawaterradio.org, or call the Water Center at (540) 231-5624. Thanks to Ben Cosgrove for his version of “Shenandoah” to open and close this episode. In Blacksburg, I'm Alan Raflo, thanking you for listening, and wishing you health, wisdom, and good water. AUDIO NOTES AND ACKNOWLEDGEMENTS “Mississippi Farewell,” from the 2022 album “Belin to Bamako,” was made available on Free Music Archive, online at at https://freemusicarchive.org/music/dieter-van-der-westen/berlin-to-bamako/mississippi-farewell/. as of 4-12-23, for use under the Creative Commons License “Attribution-NonCommercial-NoDerivatives 4.0 International”; more information on that Creative Commons License is available online at https://creativecommons.org/licenses/by-nc-nd/4.0/. Click here if you'd like to hear the full version (2 min./22 sec.) of the “Shenandoah” arrangement/performance by Ben Cosgrove that opens and closes this episode. More information about Mr. Cosgrove is available online at http://www.bencosgrove.com. IMAGE Birds' eye view of New Orleans in 1851. Drawing by J. Bachman. Image accessed from the Library of Congress' Prints and Photographs Online Catalog, online at https://www.loc.gov/pictures/item/93500720, as of 4-18-23. EXTRA INFORMATION ON THE 14TH AMENDMENT The following information about, and text of, the 14th Amendment to the U.S. Constitution was taken from National Archives, “Milestone Documents: 14th Amendment to the U.S. Constitution: Civil Rights (1868),” online at https://www.archives.gov/milestone-documents/14th-amendment. “Following the Civil War, Congress submitted to the states three amendments as part of its Reconstruction program to guarantee equal civil and legal rights to Black citizens. A major provision of the 14th Amendment was to grant citizenship to ‘All persons born or naturalized in the United States,' thereby granting citizenship to formerly enslaved people. “Another equally important provision was the statement that ‘nor shall any state deprive any person of life, liberty, or property, without due process of law; nor deny to any person within its jurisdiction the equal protection of the laws.' The right to due process of law and equal protection of the law now applied to both the federal and state governments. “On June 16, 1866, the House Joint Resolution proposing the 14th Amendment to the Constitution was submitted to the states. On July 28, 1868, the 14th amendment was declared, in a certificate of the Secretary of State, ratified by the necessary 28 of the 37 States, and became part of the supreme law of the land.” Text of 14th Amendment Section 1. All persons born or naturalized in the United States, and subject to the jurisdiction thereof, are citizens of the United States and of the state wherein they reside. No state shall make or enforce any law which shall abridge the privileges or immunities of citizens of the United States; nor shall any state deprive any person of life, liberty, or property, without due process of law; nor deny to any person within its jurisdiction the equal protection of the laws. Section 2. Representatives shall be apportioned among the several states according to their respective numbers, counting the whole number of persons in each state, excluding Indians not taxed. But when the right to vote at any election for the choice of electors for President and Vice President of the United States, Representatives in Congress, the executive and judicial officers of a state, or the members of the legislature thereof, is denied to any of the male inhabitants of such state, being twenty-one years of age, and citizens of the United States, or in any way abridged, except for participation in rebellion, or other crime, the basis of representation therein shall be reduced in the proportion which the number of such male citizens shall bear to the whole number of male citizens twenty-one years of age in such state. Section 3. No person shall be a Senator or Representative in Congress, or elector of President and Vice President, or hold any office, civil or military, under the United States, or under any state, who, having previously taken an oath, as a member of Congress, or as an officer of the United States, or as a member of any state legislature, or as an executive or judicial officer of any state, to support the Constitution of the United States, shall have engaged in insurrection or rebellion against the same, or given aid or comfort to the enemies thereof. But Congress may by a vote of two-thirds of each House, remove such disability. Section 4. The validity of the public debt of the United States, authorized by law, including debts incurred for payment of pensions and bounties for services in suppressing insurrection or rebellion, shall not be questioned. But neither the United States nor any state shall assume or pay any debt or obligation incurred in aid of insurrection or rebellion against the United States, or any claim for the loss or emancipation of any slave; but all such debts, obligations and claims shall be held illegal and void. Section 5. The Congress shall have power to enforce, by appropriate legislation, the provisions of this article. SOURCES Used for Audio Ashbrook Center at Ashland University, “Teaching American History/United States v. Cruikshank” undated, online at https://teachingamericanhistory.org/document/united-states-v-cruikshank/. Jack Beatty, Age of Betrayal: The Triumph of Money in America, 1865-1900, Vintage Books, New York, N.Y., 2007. Ronald M. Labbe and Jonathan Lurie, The Slaughterhouse Cases: Regulation, Reconstruction, and the Fourteenth Amendment, University of Kansas Press, Lawrence, 2003. Danny Lewis, “The 1873 Colfax Massacre Crippled the Reconstruction Era,” Smithsonian Magazine, April 13, 2016. Linda R. Monk, The Words We Live By: Your Annotated Guide to the Constitution, Hachette Books, New York, N.Y., 2015. Oyez (Cornell University Law School/Legal Information Institute, Justia, and Chicago-Kent College of Law), “Slaughter-House Cases,” online at https://www.oyez.org/cases/1850-1900/83us36. Melvin I. Urofsky and Paul Finkelman, A March of Liberty – A Constitutional History of the United States, Volume I: From the Founding to 1900, Third Edition, Oxford University Press, Oxford, U.K., 2011. John R. Vile, “Slaughterhouse Cases (1873),” Middle Tennessee State University/The First Amendment Encyclopedia, online at https://www.mtsu.edu/first-amendment/article/527/slaughterhouse-cases. Other Sources on the 14th Amendment to the U.S. Constitution Cornell University Law School/Legal Information Institute: “U.S. Constitution/14th Amendment,” online at https://www.law.cornell.edu/constitution/amendmentxiv; and “Fourteenth Amendment,” online at https://www.law.cornell.edu/wex/fourteenth_amendment_0. Thurgood Marshall Institute, “The 14th Amendment,” online at https://tminstituteldf.org/tmi-explains/thurgood-marshall-institute-briefs/tmi-briefs-the-14th-amendment/. NAACP, “Celebrate and Defend the Fourteenth Amendment Resolution,” 2013, online at https://naacp.org/resources/celebrate-and-defend-fourteenth-amendment. U.S. House of Representatives, “Constitutional Amendments and Major Civil Rights Acts of Congress Referenced in Black Americans in Congress,” online at https://history.house.gov/Exhibitions-and-Publications/BAIC/Historical-Data/Constitutional-Amendments-and-Legislation/. U.S. National Archives, “Milestone Documents: 14th Amendment to the U.S. Constitution: Civil Rights (1868),” online at https://www.archives.gov/milestone-documents/14th-amendment. U.S. Senate, “Landmark Legislation: The Fourteenth Amendment,” online at https://www.senate.gov/about/origins-foundations/senate-and-constitution/14th-amendment.htm. For More Information about Civil Rights in the United States British Broadcasting Corporation (BBC), “The Civil Rights Movement in America,” online at https://www.bbc.co.uk/bitesize/guides/zcpcwmn/revision/1. Howard University Law Library, “A Brief History of Civil Rights in the United States,” online at https://library.law.howard.edu/civilrightshistory/intro. University of Maryland School of Law/Thurgood Marshall Law Library, “Historical Publications of the United States Commission on Civil Rights,” online at https://law.umaryland.libguides.com/commission_civil_rights. U.S. Commission on Civil Rights, online at https://www.usccr.gov/. RELATED VIRGINIA WATER RADIO EPISODES All Water Radio episodes are listed by category at the Index link above (http://www.virginiawaterradio.org/p/index.html). See particularly the “History” subject category. This episode is part of the series, Exploring Water in U.S. Civil Rights History. As of April 17, 2023, other episodes in the series are as follows.Series overview – Episode 566, 3-1-21. Water Symbolism in African American Civil Rights History – Episode 591, 8-23-21. Uses of Water By and Against African Americans in U.S. Civil Rights History – Episode 616, 2-14-22. Water Places in U.S. Civil Rights History - Episode 619, 3-7-22.The 14th Amendment and Water-related Civil Rights Claims – Part 1: Introduction to the 14th Amendment – Episode 652, 4-3-23. FOR VIRGINIA TEACHERS – RELATED STANDARDS OF LEARNING (SOLs) AND OTHER INFORMATION Following are some Virginia Standards of Learning (SOLs) that may be supported by this episode's audio/transcript, sources, or other information included in this post. 2020 Music SOLs SOLs at various grade levels that call for “examining the relationship of music to the other fine arts and other fields of knowledge.” 2015 Social Studies SOLs Grades K-3 Civics Theme3.12 – Importance of government in community, Virginia, and the United States, including government protecting rights and property of individuals. Virginia Studies CourseVS.9 – How national events affected Virginia and its citizens. United States History to 1865 CourseUSI.9 – Causes, events, and effects of the Civil War. United States History: 1865-to-Present CourseUSII.3 – Effects of Reconstruction on American life.USII.8 – Economic, social, and political transformation of the United States and the world after World War II. Civics and Economics CourseCE.2 – Foundations, purposes, and components of the U.S. Constitution.CE.3 – Citizenship rights, duties, and responsibilities.CE.6 – Government at the national level.CE.7 – Government at the state level.CE.10 – Public policy at local, state, and national levels. Virginia and United States History CourseVUS.7 – Knowledge of the Civil War and Reconstruction eras. Government CourseGOVT.3 – Concepts of democracy.GOVT.4 – Purposes, principles, and structure of the U.S. Constitution.GOVT.5 – Federal system of government in the United States.GOVT.7 – National government organization and powers.GO
CLICK HERE to listen to episode audio (5:06).Sections below are the following: Transcript of Audio Audio Notes and Acknowledgments ImagesExtra InformationSources Related Water Radio Episodes For Virginia Teachers (Relevant SOLs, etc.). Unless otherwise noted, all Web addresses mentioned were functional as of 3-31-23. TRANSCRIPT OF AUDIO From the Cumberland Gap to the Atlantic Ocean, this is Virginia Water Radio for the weeks of April 3 and April 10, 2023. This episode, the fifth in a series on water in U.S. civil rights history, begins an exploration of water connections to the 14th Amendment of the U.S. Constitution. MUSIC – ~17 sec – instrumental. That's part of “Maple Leaf Rag,” composed by Scott Joplin and performed by Zachary Brewster-Geisz. Scott Joplin, an African American from Texas who became known as the king of ragtime music, was born in 1868. That year also brought the effective “birth” of the the 14th Amendment, which was ratified in July 1868. Have a listen to the music for about 20 more seconds, and see if you know four areas of rights addressed by the amendment. MUSIC – ~22 sec – instrumental. If you guessed any of these, you're right: citizenship, privileges and immunities, due process, and equal protection. Let's have a listen to the Section 1 of the amendment: “All persons born or naturalized in the United States, and subject to the jurisdiction thereof, are citizens of the United States and of the state wherein they reside. No state shall make or enforce any law which shall abridge the privileges or immunities of citizens of the United States; nor shall any state deprive any person of life, liberty, or property, without due process of law; nor deny to any person within its jurisdiction the equal protection of the laws.” Other sections of the amendment addressed citizens' right to vote, insurrection against the United States, Civil War debts and compensation, and finally—of great importance to future civil rights legislation—Congressional authority to enforce the amendment. The late U.S. Supreme Court Justice Thurgood Marshall, in a 1987 speech, said the following about the 14th Amendment: quote, “While the Union survived the civil war, the Constitution did not. In its place arose a new, more promising basis for justice and equality, the 14th Amendment, ensuring protection of the life, liberty, and property of all persons against deprivations without due process, and guaranteeing equal protection of the laws,” unquote. There may be no more important development in U.S. civil rights history—certainly in its legal history—than passage and ratification of the 14th Amendment. Interestingly from a water perspective, the first U.S. Supreme Court interpretation of the amendment, in 1873, addressed a law focused on water and public health; about 100 years later, water infrastructure was at issue in another significant federal court claim under the amendment; and water infrastructure is the subject of a 2022 complaint filed under the federal Civil Rights Act of 1964, for which the amendment is a significant constitutional foundation. This episode's overview sets the stage for upcoming episodes on those three 14th Amendment water stories. Thanks to Zachary Brewster-Geisz for making a recording of “Maple Leaf Rag” available for public use, and we close with about 20 more seconds of that well-known Scott Joplin tune. MUSIC – ~22 sec – instrumental. SHIP'S BELL Virginia Water Radio is produced by the Virginia Water Resources Research Center, part of Virginia Tech's College of Natural Resources and Environment. For more Virginia water sounds, music, or information, visit us online at virginiawaterradio.org, or call the Water Center at (540) 231-5624. Thanks to Stewart Scales for his banjo version of “Cripple Creek” to open and close this episode. In Blacksburg, I'm Alan Raflo, thanking you for listening, and wishing you health, wisdom, and good water. AUDIO NOTES AND ACKNOWLEDGEMENTS “Maple Leaf Rag,” composed by Scott Joplin, was first published in 1899. The recording heard in this Virginia Water Radio episode was by Zachary Brewster-Geisz, June 2006, made available on Free Music Archive, online at https://freemusicarchive.org/music/Scott_Joplin/Frog_Legs_Ragtime_Era_Favorites/03_-_scott_joplin_-_maple_leaf_rag/, as of 4-3-23, for use under Creative Commons Mark 1.0 License – Public Domain; more information on that Creative Commons License is available online at https://creativecommons.org/publicdomain/mark/1.0/. Click here if you'd like to hear the full version (1 min./11 sec.) of the “Cripple Creek” arrangement/performance by Stewart Scales that opens and closes this episode. More information about Mr. Scales and the group New Standard, with which Mr. Scales plays, is available online at http://newstandardbluegrass.com. IMAGES Photographs of the June 1866 joint resolution in Congress proposing the 14th Amendment to the U.S. Constitution. Images taken from the National Archives, online at https://www.docsteach.org/documents/document/fourteenth-amendment, as of 4/3/23. The images are made available for use under the Creative Commons license “Attribution-NonCommercial-ShareAlike 4.0 International”; more information about that Creative Commons license is available online at https://creativecommons.org/licenses/by-nc-sa/4.0/. EXTRA INFORMATION ON THE 14TH AMENDMENT The following information about, and text of, the 14th Amendment to the U.S. Constitution was taken from National Archives, “Milestone Documents: 14th Amendment to the U.S. Constitution: Civil Rights (1868),” online at https://www.archives.gov/milestone-documents/14th-amendment. “Following the Civil War, Congress submitted to the states three amendments as part of its Reconstruction program to guarantee equal civil and legal rights to Black citizens. A major provision of the 14th Amendment was to grant citizenship to ‘All persons born or naturalized in the United States,' thereby granting citizenship to formerly enslaved people. “Another equally important provision was the statement that ‘nor shall any state deprive any person of life, liberty, or property, without due process of law; nor deny to any person within its jurisdiction the equal protection of the laws.' The right to due process of law and equal protection of the law now applied to both the federal and state governments. “On June 16, 1866, the House Joint Resolution proposing the 14th Amendment to the Constitution was submitted to the states. On July 28, 1868, the 14th amendment was declared, in a certificate of the Secretary of State, ratified by the necessary 28 of the 37 States, and became part of the supreme law of the land.” Text of 14th Amendment Section 1. All persons born or naturalized in the United States, and subject to the jurisdiction thereof, are citizens of the United States and of the state wherein they reside. No state shall make or enforce any law which shall abridge the privileges or immunities of citizens of the United States; nor shall any state deprive any person of life, liberty, or property, without due process of law; nor deny to any person within its jurisdiction the equal protection of the laws. Section 2. Representatives shall be apportioned among the several states according to their respective numbers, counting the whole number of persons in each state, excluding Indians not taxed. But when the right to vote at any election for the choice of electors for President and Vice President of the United States, Representatives in Congress, the executive and judicial officers of a state, or the members of the legislature thereof, is denied to any of the male inhabitants of such state, being twenty-one years of age, and citizens of the United States, or in any way abridged, except for participation in rebellion, or other crime, the basis of representation therein shall be reduced in the proportion which the number of such male citizens shall bear to the whole number of male citizens twenty-one years of age in such state. Section 3. No person shall be a Senator or Representative in Congress, or elector of President and Vice President, or hold any office, civil or military, under the United States, or under any state, who, having previously taken an oath, as a member of Congress, or as an officer of the United States, or as a member of any state legislature, or as an executive or judicial officer of any state, to support the Constitution of the United States, shall have engaged in insurrection or rebellion against the same, or given aid or comfort to the enemies thereof. But Congress may by a vote of two-thirds of each House, remove such disability. Section 4. The validity of the public debt of the United States, authorized by law, including debts incurred for payment of pensions and bounties for services in suppressing insurrection or rebellion, shall not be questioned. But neither the United States nor any state shall assume or pay any debt or obligation incurred in aid of insurrection or rebellion against the United States, or any claim for the loss or emancipation of any slave; but all such debts, obligations and claims shall be held illegal and void. Section 5. The Congress shall have power to enforce, by appropriate legislation, the provisions of this article.
As you may have heard, we are launching a Patreon! For those that don't know what Patreon is, it's a platform that allows creators (like podcasters) to offer their followers more content, experiences, and even gifts. We have a survey that will be open for a limited time so get your input in now so we can provide the benefits you want. Maybe that's a one-on-one Zoom with me for mentorship or a genetics book/movie club or an appearance on the podcast! Let us know so we can make sure to offer it. Thanks for all your support for the podcast over the years. My guest today is Dr. Jamie Fettig, the Founder and CEO of TruGene Diagnostics. We are chatting about a breakthrough in eliminating variants of unknown significance - especially in relation to companion diagnostic tests and pharmacogenetics in oncology. Dr. Jamie Fettig is the Founder and CEO of TruGene Diagnostics, which is eliminating variants of unknown significance - especially in relation to companion diagnostic tests and pharmacogenetics in oncology. He graduated from Palmer University. Dr. Fettig previously worked in private practice and then transitioned into manufacturing and selling medical equipment. He also worked as a coach and trainer to fellow doctors. On This Episode We Discuss:Defining variants of unknown significance (VUS), pharmacogenetics and companion diagnosticsWhat TruGene Diagnostics doesThe GiggaAssayHow knowing if a breast cancer is HER2+ can help inform medications that people should be prescribedVUS in HER2 Tyrosine Kinase RegionWhat people should do if they get HER2+ cancer or their doctor wants to do a biopsy thinking it might be HER2+How cancer survival rates are impacted by utilizing precision medicine approaches with drugsHow TruGene Diagnostics' test differs from other PGx tests or Precision MedsHow pharmacogenomics can increase the efficacy of clinical trialsCheck out Dr. Fettig's papers:Heligenics: fulfilling the promise of the functional genome to enable precision medicine (March, 2023)Data Supporting a saturation mutagenesis assay for Tat-driven transcription with the GigaAssay (September 2022)GigaAssay – a high-throughput assay system for molecular functions and cell processes (July 2021)Check out DNA Today Episode 134 that Kira mentioned during this episode; it's with guest Dr. Kat Arney about cancer evolution. You can also stream other episodes about pharmacogenomics including Episode #108 with Becky Winslow, Episode #174 with Gregory Kellog, and last week's Episode #229 with Avni Santani! Stay tuned for the next new episode of DNA Today on April 7th, 2023, where we'll be discussing ChatGPT and AI In Genetics with Daniel Uribe of GenoBank! New episodes are released every Friday. In the meantime, you can binge over 225 other episodes on Apple Podcasts, Spotify, streaming on the website, or any other podcast player by searching, “DNA Today”. Episodes since 2021 are also recorded with video which you can watch on our YouTube channel. DNA Today is hosted and produced by Kira Dineen. Our social media lead is Corinne Merlino. Our video lead is Amanda Andreoli. Our Outreach Intern is Sanya Tinaikar. Our Social Media Intern is Kajal Patel. And our Graphic Designer Ashlyn Enokian.See what else we are up to on Twitter, Instagram, Facebook, YouTube and our website, DNAToday.com. Questions/inquiries can be sent to info@DNAtoday.com. Surely you have heard of whole genome sequencing, but what about rapid and ultra-rapid whole genome sequencing? This is an emerging method of diagnosing genetic conditions for quick management. PerkinElmer Genomics offers this incredibly valuable test, which can be life saving for ill babies and kids. Learn more in our full episode (#226) with PerkinElmer Genomics. You can visit perkinelmergenomics.com for more information. (Sponsored)Juno Diagnostics has developed the next generation of non-invasive prenatal tests so that all pregnant people can access a higher standard of care. Juno Diagnostics is the only genetic testing company on the market that performs NIPS for common aneuploidies on blood samples from a finger stick instead of a traditional venous blood draw. That means you collect your sample on your own time, at home, and still have NIPS at a CLIA laboratory! Juno's Hazel™ NIPS screens for common chromosome variations seen in pregnancy, such as Down syndrome or trisomy 21, trisomy 13, and trisomy 18 – in addition to testing for fetal sex. You can order this test yourself, or have your healthcare provider order for you. Head to JunoDx.com and use the code "DNATODAY” for 10% off! Keep your eye out for our full episode interview with experts from Juno Dx including fellow genetic counselor Katie Sagaser and Dr. Allison Rodgers. In the meantime, check out JunoDx.com to learn more about Hazel and their other test Birch (which tests just for the sex of your baby). (Sponsored)
CLICK HERE to listen to episode audio (5:12).Sections below are the following: Transcript of Audio Audio Notes and Acknowledgments ImagesSourcesRelated Water Radio Episodes For Virginia Teachers (Relevant SOLs, etc.). Unless otherwise noted, all Web addresses mentioned were functional as of 3-17-23. TRANSCRIPT OF AUDIO From the Cumberland Gap to the Atlantic Ocean, this is Virginia Water Radio for the weeks of March 20 and March 27, 2023. MUSIC – ~24 sec – Lyrics: “We are on a ship, a great big ship. It takes all of us to take care of it. And we can use the stars to navigate our trip. We are riding on a ship.” “That's part of “On a Ship,” by Blacksburg, Va., musician Kat Mills. It opens an episode about two recent international meetings on our planetary ship's ocean waters. Have a listen for about 15 seconds to sounds of two ocean-going creatures—a Humpback Whale, and a Leach's Storm-Petrel—and see if you know what aspect of ocean biology was a key focus of the meetings. And here's a hint: you've got this, if you've got a lot of different living things in the sea. SOUNDS - ~17 sec If you guessed marine biodiversity, you're right! According to the American Museum of Natural History in New York, biodiversity means, quote, “the variety of life on Earth at all its levels, from genes to ecosystems, and can encompass the evolutionary, ecological, and cultural processes that sustain life,” unquote. In early March 2023, two international gatherings focused on biodiversity in marine waters, including in what's called the “high seas,” the waters and ocean floor areas that are more than 200 nautical miles from any nation's shores and are not under any single nation's jurisdiction. According to the Marine Conservation Institute, the high seas cover about half of the Earth's surface, contain great biodiversity, and are among the least-protected areas on Earth. On March 2 and 3, the eighth Our Ocean Conference was held in Panama, with participants from government, business, and non-profits making voluntary commitments for $20 billion towards protecting marine areas, addressing marine pollution, helping indigenous coastal communities, and other objectives. Since 2014, Our Ocean Conference participants have made over 1800 commitments worth over $100 billion. Meanwhile, at a United Nations conference on March 4 in New York, a majority of the world's nations agreed on language for a so-called “High Seas Treaty,” in the works since 2004. If ultimately ratified by individual countries, it would facilitate protected areas, fund marine conservation, provide guidelines for marine genetic resources, and provide capacity building and technology transfer to developing states. Both meetings are part of a worldwide effort called 30 by 30, that is, by 2030 to conserve and restore 30 percent of the world's land and oceans important for biodiversity, a target set at a U.N. biodiversity conference in Montreal in December 2022. Thanks to Kat Mills for permission to use “On a Ship”; to the National Park Service for the Humpback Whale sound; and to Lang Elliott for the Leach's Storm-Petrel sound, from the Stokes Field Guide to Bird Songs. We close with another musical selection whose title and tune may conjure up images of the oceans. Here's about 15 seconds of “Driftage,” by Andrew and Noah VanNorstrand. MUSIC - ~17 sec – instrumental [start at about [5:14 and go to abrupt end at 5:30]. SHIP'S BELL Virginia Water Radio is produced by the Virginia Water Resources Research Center, part of Virginia Tech's College of Natural Resources and Environment. For more Virginia water sounds, music, or information, visit us online at virginiawaterradio.org, or call the Water Center at (540) 231-5624. Thanks to Ben Cosgrove for his version of “Shenandoah” to open and close this episode. In Blacksburg, I'm Alan Raflo, thanking you for listening, and wishing you health, wisdom, and good water. AUDIO NOTES AND ACKNOWLEDGEMENTS “On a Ship,” from the 2015 album “Silver,” is copyright by Kat Mills, used with permission. More information about Kat Mills is available online at http://www.katmills.com/. This music was used previously by Virginia Water Radio most recently in Episode 609, 12-27-21. The Humpback Whale sound was from the National Park Service ‘Sound Gallery,” online at https://www.nps.gov/subjects/sound/sounds-humpback-whale.htm, as of 3-16-23. The Leach's Storm-Petrel sound was from the Stokes Field Guide to Bird Songs-Eastern Region CD set, by Lang Elliott with Donald and Lillian Stokes (Time Warner Audio Books, copyright 1997), used with permission of Lang Elliott. Lang Elliot's work is available online at the “Music of Nature” Web site, http://www.musicofnature.org/. “Driftage,” from the 2004 album of same name, is copyright by Andrew and Noah VanNorstrand and Great Bear Records, used with permission. More information about Andrew and Noah and their bands is available online at https://andrewandnoah.bandcamp.com/music. Click here if you'd like to hear the full version (2 min./22 sec.) of the “Shenandoah” arrangement/performance by Ben Cosgrove that opens and closes this episode. More information about Mr. Cosgrove is available online at http://www.bencosgrove.com. IMAGES Humpback Whale. Image from the NOAA [National Oceanic and Atmospheric Administration] Photo Library, “NOAA's Ark/Whales,” online at https://photolib.noaa.gov/Collections/NOAAs-Ark; the URL for the specific photo was https://photolib.noaa.gov/Collections/NOAAs-Ark/Whales/emodule/722/eitem/30376, as of 3-21-23.Wilson's Storm-Petrels. Photo by Lieutenant Elizabeth Crapo, accessed in the NOAA [National Oceanic and Atmospheric Administration] Photo Library, “NOAA's Ark/Birds,” online at https://photolib.noaa.gov/Collections/NOAAs-Ark; the URL for the specific photo was https://photolib.noaa.gov/Collections/NOAAs-Ark/Birds/emodule/727/eitem/28716, as of 3-21-23.SOURCES Used for Audio Elizabeth Claire Alberts, “Panama ocean conference draws $20 billion, marine biodiversity commitments,” March 6, 2023, online at https://news.mongabay.com/2023/03/panama-ocean-conference-draws-20-billion-marine-biodiversity-commitments/. American Museum of Natural History, “What is Biodiversity?” Online at https://www.amnh.org/research/center-for-biodiversity-conservation/what-is-biodiversity. Audubon, “Leach's Storm-Petrel,” online at https://www.audubon.org/field-guide/bird/leachs-storm-petrel. Michael Casey, “Historic biodiversity agreement reached at UN conference,” Associated Press, December 19, 2022. Catrin Einhorn, “Nations Agree on Language for Historic Treaty to Protect Ocean Life; The United Nations agreement is a significant step toward protecting biodiversity under growing threat from climate change, overfishing and seabed mining,” New York Times, March 4, 2023. Catrin Einhorn, “Nearly Every Country Signs On to a Sweeping Deal to Protect Nature,” New York Times, December 20, 2022. Christina Larson and Patrick Whittle, “Nations reach accord to protect marine life on high seas,” AP [Associated Press] News, March 5, 2023. Marine Conservation Institute, “Protecting the High Seas,” online at https://marine-conservation.org/high-seas/. Ministry of Foreign Affairs of the Republic of Indonesia, “Indonesian Delegation Successfully States Commitment to Protecting the Marine Environment at the Our Ocean Conference 2023,” March 3, 2023. NOAA [National Oceanic and Atmospheric Administration] Fisheries, “Humpback Whale,” online at https://www.fisheries.noaa.gov/species/humpback-whale. Our Ocean Panama March 2-3. 2023, online at https://ouroceanpanama2023.gob.pa/, as of 3/16/23. St. Louis Post-Dispatch Editorial Board, “Editorial: Developing accord could vastly improve oceans' survival chances,” March 12, 2023. United Nations, “UN delegates reach historic agreement on protecting marine biodiversity in international waters,” UN News, March 5, 2023. United Nations Convention on Biological Diversity, online at https://www.cbd.int/article/cop15-final-text-kunming-montreal-gbf-221222, “COP15: Final text of Kunming-Montreal Global Biodiversity Framework,” December 22, 2022, News Release. United Nations Intergovernmental Conference on Marine Biodiversity of Areas Beyond National Jurisdiction, online at https://www.un.org/bbnj/. U.S. Agency for International Development (USAID), “USAID Announces New Programs to Protect Our Ocean at the 2023 Our Ocean Conference,” March 3, 2023. Worldwide Fund for Nature, “Whales Without Boundaries – Why the High Seas Matter,” online at https://wwfwhales.org/news-stories/whales-without-boundaries-why-the-high-seas-matter. John Yang and Lorna Baldwin, “Historic deal to protect ocean biodiversity reached at UN conference,” PBS NewsHour, March 5, 2023. [6 min./45 sec. video with transcript.] For More Information about Biodiversity in Oceans and Elsewhere National Oceanic and Atmospheric Administration (NOAA), online at https://www.noaa.gov/. Some of the agency's many specific topic pages are the following:“Biological Diversity and Related Issues,” online at https://www.noaa.gov/biological-diversity-and-related-issues;“Ocean Exploration Facts,” online at https://oceanexplorer.noaa.gov/facts/facts.html;“Marine Life,” online at https://www.noaa.gov/education/resource-collections/marine-life;“U.S. Marine Biodiversity Observing Network,” online at https://oceanservice.noaa.gov/news/apr16/mbon.html. RELATED VIRGINIA WATER RADIO EPISODES All Water Radio episodes are listed by category at the Index link above (http://www.virginiawaterradio.org/p/index.html). See particularly the “Birds” and “Mammals” subject categories. Following is a link to a previous episode on biodiversity (generally in Virginia, not specifically marine biodiversity). Episode 260, 4-6-15 – Biodiversity in Virginia and the Southern Appalachian Mountains. Following are links to some previous episodes on organisms inhabiting oceans. Episode 399, 12-18-17 – Whales in Song, Sound, and Migration Past Virginia.Episode 542, 9-14-20 – Dolphins in Sound and Music.Episode 551, 11-16-20 – Sea Creatures Sound Off. FOR VIRGINIA TEACHERS – RELATED STANDARDS OF LEARNING (SOLs) AND OTHER INFORMATION Following are some Virginia Standards of Learning (SOLs) that may be supported by this episode's audio/transcript, sources, or other information included in the episode's post. 2020 Music SOLs SOLs at various grade levels that call for “examining the relationship of music to the other fine arts and other fields of knowledge.” 2018 Science SOLs Grades K-4: Living Systems and Processes2.5 – Living things are part of a system.3.5 – Aquatic and terrestrial ecosystems support a diversity of organisms. Grades K-5: Earth and Space Systems3.7 – There is a water cycle and water is important to life on Earth.4.7 – The ocean environment. Grades K-5: Earth Resources3.8 – Natural events and humans influence ecosystems.4.8 – Virginia has important natural resources. Grade 66.6 – Water has unique physical properties and has a role in the natural and human-made environment.6.8 – Land and water have roles in watershed systems.6.9 – Humans impact the environment and individuals can influence public policy decisions related to energy and the environment. Life ScienceLS.6 – Populations in a biological community interact and are interdependent.LS.8 – Change occurs in ecosystems, communities, populations, and organisms over time.LS.9 – Relationships exist between ecosystem dynamics and human activity. Earth ScienceES.6 – Resource use is complex.ES.10 – Oceans are complex, dynamic systems subject to long- and short-term variations. BiologyBIO.8 – Dynamic equilibria exist within populations, communities, and ecosystems. 2015 Social Studies SOLs Grades K-3 Economics Theme2.8 – Natural, human, and capital resources.3.8 – Understanding of cultures and of how natural, human, and capital resources are used for goods and services. United States History: 1865-to-Present CourseUSII.9 – Domestic and international issues during the second half of the 20th Century and the early 21st Century. Civics and Economics CourseCE.6 – Government at the national level.CE.10 – Public policy at local, state, and national levels. World Geography CourseWG.2 – How selected physical and ecological processes shape the Earth's surface, including climate, weather, and how humans influence their environment and are influenced by it.WG.4 – Types and significance of natural, human, and capital resources.WG.18 – Cooperation among political jurisdictions to solve
durée : 00:13:35 - comment le recours au 49.3 et les manifestations qui éclatent depuis sont vus à l'étranger ? -
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